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SUMMARY:[The Svedberg seminar]-Molecular Mechanism of RNA Splicing by the Spliceosome
DESCRIPTION:Yigong ShiProfessor School of Life Sciences\, Westlake University\, Hangzhou\, China \n\n\n\n \n\n\n\nTHE LENNART PHILIPSON MEMORIAL LECTURE 2025 \n\n\n\nLecture hall A1:107a\, BMC\, Uppsala University Wednesday\, October 22\, 2025 at 3:15 pm   \n\n\n\nBio \n\n\n\nProfessor Yigong Shi is a biophysicist and the current president of Westlake University. He received aBachelor of Science from Tsinghua University in 1989 and a Doctor of Philosophy in molecularbiophysics from Johns Hopkins University in 1995. Yigong Shi has been the Warner-Lambert/Parke-Davis Professor in the department of Molecular Biology at Princeton University. Since 2008\, hecontinued his career at Tsinghua University\, where he was appointed Dean of Tsinghua’s School ofLife Sciences. In 2018\, he became the founding and first president of Westlake University\, a newlyestablished private university in Hangzhou.His laboratory combines structural biology\, biochemical and biophysical approaches to elucidate themolecular and chemical basis of fundamental cellular events\, with a particular interest inspliceosome-catalyzed pre-mRNA splicing\, the mechanism of regulated intramembrane proteolysis\,and the initiation of apoptosis.Yigong Shi’s laboratory has been working on the structural elucidation of the spliceosome since 2008.Initially\, his lab solved the crystal structures of select spliceosomal components. In the summer of2015\, they published two seminal papers on the intact\, functional yeast spliceosome structure at 3.6-Å resolution. Since then\, they have reported the cryo-EM structures of the yeast spliceosome inseven states and human spliceosome in three states\, which together elucidate the choreography ofthe assembly and catalysis of the spliceosome.Representative publications and an animation (https://ygshi.org/research?0) on the spliceosomehighlight the essence of this year’s Lennart Philipson Memorial Lecture:Hang J\, Wan R\, Yan C\, Shi Y. Structural basis of pre-mRNA splicing. Science. 2015;349(6253):1191-8.Yan C\, Hang J\, Wan R\, Huang M\, Wong CC\, Shi Y. Structure of a yeast spliceosome at 3.6-angstromresolution. Science. 2015;349(6253):1182-91. Yan C\, Wan R\, Shi Y. Molecular Mechanisms of premRNASplicing through Structural Biology of the Spliceosome. Cold Spring Harb Perspect Biol.2019;11(1):a032409.Welcome!
URL:https://www.scilifelab.se/event/the-svedberg-seminar-yigong-shi/
LOCATION:BMC Lecture hall A1:107a\, BMC\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
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