BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//SciLifeLab - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:SciLifeLab
X-ORIGINAL-URL:https://www.scilifelab.se
X-WR-CALDESC:Events for SciLifeLab
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Stockholm
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221201T120000
DTEND;TZID=Europe/Stockholm:20221201T130000
DTSTAMP:20260522T225301
CREATED:20220912T094220Z
LAST-MODIFIED:20221121T090652Z
UID:10000676-1669896000-1669899600@www.scilifelab.se
SUMMARY:Campus Solna Seminar Series: Pontus Höjer and Guido Baselli
DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an  initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nPontus Höjer\n\n\n\nAfshin Ahmadian – alpha 3 \n\n\n\nOmics exploration with Droplet Barcode Sequencing (DBS). \n\n\n\n\n\nGuido Baselli\n\n\n\nVicent Pelechano – gamma 5 \n\n\n\nIdentification of novel factors regulating non genetic cell plasticity in Chronic Myeloid Leukemia. \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
URL:https://www.scilifelab.se/event/campus-solna-seminar-series-dec-1/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_124630107_HDR-scaled.jpg
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221206T110000
DTEND;TZID=Europe/Stockholm:20221206T120000
DTSTAMP:20260522T225301
CREATED:20221201T122659Z
LAST-MODIFIED:20221201T122702Z
UID:10000743-1670324400-1670328000@www.scilifelab.se
SUMMARY:SciLifeLab Uppsala PhD&Postdoc Online Seminar Series – Cancer Theme
DESCRIPTION:Welcome back to the SciLifeLab Uppsala PhD&Postdoc seminar series! \nThis seminar will take place on Tuesday December 6 from 11h to 11:50h on Zoom (https://uu-se.zoom.us/j/66489618700) \nFor this occasion the speakers will be: \n1. Xiaonan Zhang\, Postdoc at Tobias Sjöblom’s Lab (Cancer Precision Medicine)\, Dept. of Immunology\, Genetics and Pathology\, Uppsala University\n\n\nTitle:  Exploiting allelic loss in cancer therapy: Identification of NAT2 and CYP2D6 as potential targets\n\nSummary:\nLoss of heterozygosity (LOH) is observed in >90% of human cancers and results in the loss of allelic variation in thousands of genes. LOH thus creates genetic differences between tumor and normal cells\, particularly at gene loci where the individual is heterozygous for a wildtype and a loss-of-function (LoF) allele. We have sought to identify genes with common LoF polymorphisms where tumor cells that have lost the gene activity can be targeted by low-molecular-weight drugs or other means. We previously reported that recurring LOH at the NAT2 locus at 8p22 in colorectal cancers (CRCs)\, and the ensuing loss of NAT2 enzyme activity\, could be exploited for anticancer therapy. Recently\, we discovered a group of ATPase inhibitors that exhibited specific toxicity to CRC cells with high NAT2 activity. In parallel\, we investigated the CYP2D6 locus as the CYP2D6 enzyme metabolizes ~25% of clinically used drugs and frequently undergoes LOH in several tumor types. We have established liver cancer cell models and demonstrated that the activity of three anti-cancer compounds\, used in clinic or in clinical trials\, is dependent on CYP2D6. We anticipate that a subset of CRC and liver cancer patients with LOH events in NAT2 or CYP2D6 will benefit from this research. \n\n\n\n2. Kehuan Wang\, PhD Student at Carl-Henrik Heldin’s Lab (Cancer)\, Dept. of Medical Biochemistry and Microbiology\, Uppsala University\n\nTitle: The Proteasomal\, Lysosomal and Autophagosomal Degradation Pathways of PDGFRβ\n\nSummary:\n\nPlatelet-derived growth factor (PDGF)-induced signaling via PDGF receptor β (PDGFRβ) leads to activation of downstream signaling pathways which regulate multiple cellular responses\, such cell migration\, proliferation and survival. Signaling via PDGFRβ is dependent on subcellular location of signaling molecules and hence the internalization of the receptor. It is not clear exactly how PDGFRβ is degraded\, both endosomal/lysosomal and proteasomal degradation has been suggested. In this study\, we have characterized the proteolytic cleavage of ligand-induced PDGFRβ and found that proteolytic cleavage of PDGFRβ resulted in two fragments. This cleavage is dependent on the internalization of PDGFRβ\, which can be blocked by the treatment with bortezomib. Treatment with bortezomib resulted in increased phosphorylation of PDGFRβ and the down-stream signaling molecules PLCγ and STAT3\, while phosphorylation of Erk1/2 MAPK was reduced and Akt was unaffected. We also investigated the possibility that PDGFRβ is degraded by selective autophagy in response to starvation or ligand-induced downregulation of receptor from the cell surface. We found that PDGFRβ accumulated in cells treated with bafilomycin A1 upon serum starvation which could be reversed by inhibition of protein synthesis with cycloheximide. Overexpression of LC3A\, but not LC3B\, promoted the formation of a complex between PDGFRβ and p62. Additionally\, PDGFRβ interacted with LC3A and other members of LC3-like family\, i.e. GABARAP and GABARAPL1. In conclusion\, we speculate that the step-wise proteolytic cleavage of PDGFRβ may have functional consequences for signaling. Macroautophagy may not play a major role in ligand-induced downregulation of PDGFRβ but it could be involved in downregulation of PDGFRβ during starvation via targeting by p62 to non-conventional autophagic or proteasomal pathways that include LC3A and GABARAPs. The functional involvement of these pathways in the control of PDGFRβ levels remains to be further investigated.
URL:https://www.scilifelab.se/event/scilifelab-uppsala-phdpostdoc-online-seminar-series-cancer-theme/
LOCATION:Online event via Zoom
CATEGORIES:Community
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/11/SciLifeLab-PhDPostdoc-conuncil-poster_landscape_December_6.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221214T090000
DTEND;TZID=Europe/Stockholm:20221214T110000
DTSTAMP:20260522T225301
CREATED:20221128T124459Z
LAST-MODIFIED:20221212T101122Z
UID:10000742-1671008400-1671015600@www.scilifelab.se
SUMMARY:Web-editing Workshop for Unit Website Editors
DESCRIPTION:Current or future editors of unit websites on the SciLifeLab.se website are welcome to join this workshop. \n\n\n\nRegister\n\n\n\nWorkshop will be managed by David Gotthold from the Operations Office. The Workshop will contain: \n\n\n\n\nAccount set-up and permissions\n\n\n\nHow to Log-in\n\n\n\nIntroduction to Word Press\n\n\n\nEditing Basics\n\n\n\nSuggestions for headlines at all unit websites\n\n\n\nOther resources on the SciLifeLab \n\n\n\nThe workshop will end with a 30 minute co-working session where you work individually and can get individual assistance\n\n\n\n\nDavid GottholdProject leaderEvent management\, visits coordination\, webmaster\, communicationsdavid.gotthold@scilifelab.se +46 (0) 72 858 91 03
URL:https://www.scilifelab.se/event/web-editing-workshop-for-unit-website-editors-2/
LOCATION:Online event via Zoom
CATEGORIES:Community
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221215T120000
DTEND;TZID=Europe/Stockholm:20221215T130000
DTSTAMP:20260522T225301
CREATED:20220912T095057Z
LAST-MODIFIED:20221129T094808Z
UID:10000679-1671105600-1671109200@www.scilifelab.se
SUMMARY:Campus Solna Seminar Series: Bruno Urien and Kalliroi Sdougkou
DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an  initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nBruno Urien\n\n\n\nBennie Lemmens – alpha 5 \n\n\n\nStudy of Nuclear DNA Replication using Structured Illumination Microscopy. \n\n\n\n\n\nKalliroi Sdougkou\n\n\n\nJonathan Martin – gamma 5 \n\n\n\nSample preparation workflows for enhanced chemical exposomics in human plasma. \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
URL:https://www.scilifelab.se/event/campus-solna-seminar-series-dec-15/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_123412496_HDR2-scaled.jpg
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
END:VCALENDAR