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X-WR-CALDESC:Events for SciLifeLab
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260120T151500
DTEND;TZID=Europe/Stockholm:20260120T161500
DTSTAMP:20260421T192248
CREATED:20260108T130106Z
LAST-MODIFIED:20260113T112254Z
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SUMMARY:Mapping cells at scale: from tissue volumes to community challenges in vEM
DESCRIPTION:Speaker: Aubrey WeigelProject Scientist\, CellMap Project TeamHoward Hughes Medical Institute\, Janelia Research Campus \n\n\n\nAbstract\n\n\n\n\n\n\n\nLarge-scale\, high-resolution imaging of subcellular architecture using volume electron microscopy (vEM) unlocks new opportunities for biological discovery – but realizing this potential requires more than just data acquisition. Scalable infrastructure\, robust protocols\, and trained personnel are critical to extract consistent insight from these complex datasets and make them useful to the broader community. The CellMap Project Team represents a coordinated effort to scale vEM-based segmentation across six dimensions: dataset scale\, biological diversity\, organelle classification complexity\, team training\, analytical depth\, and open access.  \n\n\n\nThrough modular training programs\, systematic quality control\, and block-wise processing tools\, the project has grown from individual cell volumes to tissue-scale annotation across dozens of organisms and sample types. Annotated datasets are openly shared through OpenOrganelle\, providing the community with immediate access to high-resolution volumes and voxel-level segmentations. To further catalyze progress in automated segmentation\, we launched the CellMap Segmentation Challenge – a large-scale\, open competition featuring expertly annotated training data from over 20 eFIB-SEM datasets and more than 40 unique organelle classes.  \n\n\n\nWe describe how workflows and infrastructure evolved to support this scaling effort\, with a focus on designing datasets that are tailored for specific biological insight yet structured for broad reuse. By scaling people\, protocols\, and pipelines in parallel – and committing to open data practices – the CellMap Project Team provides a model for reproducible\, high-resolution cellular mapping at scale. \n\n\n\nregistration\n\n\n\nBiography \n\n\n\nAubrey Weigel is currently a Project Scientist of the CellMap Project Team at HHMI – Janelia Research Campus. The team uses advanced imaging technologies to study the ultrastructure of subcellular organelles under both healthy and pathological conditions. Aubrey’s previous research background is in biophysics\, with an emphasis in microscopy. Her formal training is in physics and engineering.  \n\n\n\nDuring her graduate work Aubrey was the co-discoverer of ergodicity breaking in cells along with Diego Krapf\, driving a pivotal shift in the field of diffusion analysis in living systems. Throughout her postdoctoral career under the guidance of Jennifer Lippincott-Schwartz\, she applied her training in physics and microscopy directly to answer biological questions. Here\, Aubrey unraveled the underlying structure of the endoplasmic reticulum and revealed its complex dynamics. She also uncovered the nano-anatomy of early secretory compartments and discovered a new\, dynamic organelle\, responsible for delivering newly synthesized cargo from the endoplasmic reticulum to the Golgi.  \n\n\n\nAubrey’s recent work as the leader of the Cell Organelle Segmentation in Electron Microscopy (COSEM) project includes developing an invaluable tool for cell biology – an analysis pipeline based on deep learning architectures for segmentation – allowing comprehensive reconstruction and analysis of organelles within entire cells imaged by volumetric electron microscopy. CellMap is now building upon this pipeline to generate\, characterize\, and discover how cells look in their native tissue environments – acting as a hub of collaborations that brings together scientists of different disciplines. Aubrey is committed to integrating her multi-disciplinary training into facilitating large-effort\, collaborative\, team projects to take on challenging scientific problems and sharing these resources with the broader scientific community.
URL:https://www.scilifelab.se/event/mapping-cells-at-scale-from-tissue-volumes-to-community-challenges-in-vem/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg
ORGANIZER;CN="Spotlight Seminar Series":MAILTO:events@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260123T090000
DTEND;TZID=Europe/Stockholm:20260123T170000
DTSTAMP:20260421T192248
CREATED:20251204T133007Z
LAST-MODIFIED:20260119T080732Z
UID:10001679-1769158800-1769187600@www.scilifelab.se
SUMMARY:Unlocking Precision Health: From Molecular Insights to Clinical Impact in Complex Diseases
DESCRIPTION:The 3rd Symposium on Complex Diseases \n\n\n\nJoin us for an exciting day dedicated to advancing precision health and tackling the challenges of complex diseases. This symposium brings together leading researchers\, clinicians\, and industry to explore how molecular insights can transform clinical practice and improve patient outcomes. \n\n\n\nFor information about the symposium in Swedish: Unlocking Precision Health: From Molecular Insights to Clinical Impact in Complex Diseases (Swe). \n\n\n\nConfirmed Speakers:\n\n\n\n\nOskar Frisell\, Karolinska Institutet\n\n\n\nAndrea Ganna\, University of Helsinki\, Finland\n\n\n\nLina Jonsson\, University of Gothenburg\n\n\n\nRichard Landberg\, Chalmers University of Technology\n\n\n\nTuuli Lapalainen\, KTH Royal Institute of Technology\n\n\n\nRuth Loos\, University of Copenhagen\, Denmark\n\n\n\nOlle Melander\, Lund University\n\n\n\nRichard Rosenquist Brandell\, Karolinska Institutet\n\n\n\nPeter Würtz\, Nightingale Health\, Finland\n\n\n\n\nRegistration\n\n\n\nRegister via this form: https://forms.gle/6C7QzrzxwJ9NBPjd8. Registration deadline: 15 January 2026 \n\n\n\nAbstract Submission deadline: 5 January 2026 \n\n\n\nProgram\n\n\n\nProgram symposium complex diseases Jan 23 2026_FINALDownload\n\n\n\nWhy attend?\n\n\n\nExpand your expertise in genomics\, multi-omics\, and precision medicine. \n\n\n\nNetwork with experts and peers across academia\, healthcare\, and industry. \n\n\n\nParticipate in rapid talks\, poster sessions\, and lively discussions.
URL:https://www.scilifelab.se/event/unlocking-precision-health-from-molecular-insights-to-clinical-impact-in-complex-diseases/
LOCATION:Operaterassen\, Karl XII:s Torg\, Stockholm\, Sweden
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260123T100000
DTEND;TZID=Europe/Stockholm:20260123T110000
DTSTAMP:20260421T192248
CREATED:20251219T093846Z
LAST-MODIFIED:20251219T113322Z
UID:10001686-1769162400-1769166000@www.scilifelab.se
SUMMARY:Genetic code reprogramming for the discovery of macrocycles for therapeutic innovation
DESCRIPTION:Hiroaki Suga\, Ph.D.Professor\, Department of Chemistry\, School of Science\, The University of Tokyo \n\n\n\nHiroaki Suga is best known for his work on artificial ribozymes (Flexizyme) and their application in mRNA display (RaPID\, random nonstandard peptide integrated discovery). He is also the founder of the very successful drug discovery company PeptiDream\, Inc. He was awarded the Wolf Prize in Chemistry in 2023. \n\n\n\nHost: David Drew\, SciLifeLab
URL:https://www.scilifelab.se/event/genetic-code-reprogramming-for-the-discovery-of-macrocycles-for-therapeutic-innovation/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260126T151500
DTEND;TZID=Europe/Stockholm:20260126T161500
DTSTAMP:20260421T192248
CREATED:20251211T124150Z
LAST-MODIFIED:20251211T124151Z
UID:10001681-1769440500-1769444100@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - How to Terminate Transcription at the Right Place
DESCRIPTION:Gene‑Wei Li \n\n\n\nAssociate Professor Massachusetts Institute of Technology (MIT)\, USA \n\n\n\nBio\n\n\n\nGene‑Wei Li is an Associate Professor of Biology at Massachusetts Institute of Technology (MIT) and an Investigator at Howard Hughes Medical Institute (HHMI). He earned a B.S. in Physics from National Tsinghua University (2004) and a Ph.D. in Physics from Harvard University (2010)\, followed by a postdoctoral fellowship at University of California\, San Francisco (UCSF). His research focuses on how bacterial genomes encode quantitative control over protein production — exploring how cells optimize proteome composition through precise regulation of transcription\, translation\, and RNA processing. \n\n\n\nHow to Terminate Transcription at the Right Place \n\n\n\nPrecise transcription termination is essential for defining gene boundaries and achieving proper RNA output. I will discuss two recent advances regarding transcription termination in bacteria. First\, we re-defined the features required for intrinsic terminators: in addition to the canonical hairpin and U-tract\, two conserved sequence motifs are also necessary. This new definition quantitatively explains variations in termination efficiency and accurately pinpoints functional terminators genome-wide. Second\, we showed that many bacteria have evolved purine-rich genes to avoid premature transcription termination\, especially in species with “runaway transcription\,” i.e.\, those uncoupled transcription-translation. This bias imposes strong evolutionary constraints on codon usage and the assimilation of foreign genes. Together\, these principles illuminate the design principles of bacterial gene sequences and how genomes encode the correct endpoints of transcription \n\n\n\n \n\n\n\nHost: Johan Elf johan.elf@icm.uu.se UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-gene-wei-li/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260127T080000
DTEND;TZID=Europe/Stockholm:20260128T150000
DTSTAMP:20260421T192248
CREATED:20250624T150224Z
LAST-MODIFIED:20250925T083137Z
UID:10001570-1769500800-1769612400@www.scilifelab.se
SUMMARY:Metabolomics in Life Science
DESCRIPTION:After the great success of the 2024 Metabolomics in Life Science conference\, the Organizing Committee is thrilled to announce the second edition in 2026!Date: 27-28 January\, 2026Venue: Vävenscenen\, Umeå \n\n\n\n\nUmeå University warmly invites you to Metabolomics in Life Science 2026\, showcasing the latest NMR- and MS-based metabolomics research from Sweden\, the Nordics\, and beyond. The conference brings together researchers from around the world to share knowledge and discuss advances in areas like clinical and precision medicine\, plant metabolomics\, spatial and single-cell metabolomics\, multi-omics\, and computational/AI applications. \n\n\n\nThe event is organized by SciLifeLab platforms in Umeå: Swedish NMR Centre (SNC)\, Swedish Metabolomics Centre (SMC)\, and Computational Analytics Support Platform (CASP). \n\n\n\nThe program includes six keynote speakers from leading institutions\, plus an industry exhibition showcasing the latest technologies and services in metabolomics research. \n\n\n\nRegistration is now open – Register here \n\n\n\nQuestions? Contact: \n\n\n\n\nIlona Dudka – ilona.dudka@umu.se\n\n\n\nKate Bennett – katie.bennett@umu.se\n\n\n\n\nLooking forward to welcoming everyone in Umeå in January 2026! \n\n\n\nRead more\n\n\n\nOrganizersSwedish Metabolomics Centre (SMC)  \n\n\n\nNMR Core facility \n\n\n\nComputational Analytics Support Platform (CASP)
URL:https://www.scilifelab.se/event/metabolomics-in-life-science/
LOCATION:Väven\, Storgatan 46A\, Umeå\, 90326\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/06/Umea.png
ORGANIZER;CN="Swedish Metabolomics Centre (SMC)":MAILTO:annika.johansson01@umu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260127T140000
DTEND;TZID=Europe/Stockholm:20260127T150000
DTSTAMP:20260421T192248
CREATED:20260119T123255Z
LAST-MODIFIED:20260123T100047Z
UID:10001725-1769522400-1769526000@www.scilifelab.se
SUMMARY:How to Terminate Transcription at the Right Place
DESCRIPTION:Gene‑Wei Li\, Associate Professor Massachusetts Institute of Technology (MIT)\, USA \n\n\n\n\n\n\n\nAbstract\n\n\n\nPrecise transcription termination is essential for defining gene boundaries and achieving proper RNA output. I will discuss two recent advances regarding transcription termination in bacteria. First\, we re-defined the features required for intrinsic terminators: in addition to the canonical hairpin and U-tract\, two conserved sequence motifs are also necessary. This new definition quantitatively explains variations in termination efficiency and accurately pinpoints functional terminators genome-wide. Second\, we showed that many bacteria have evolved purine-rich genes to avoid premature transcription termination\, especially in species with “runaway transcription\,” i.e.\, those uncoupled transcription-translation. This bias imposes strong evolutionary constraints on codon usage and the assimilation of foreign genes. Together\, these principles illuminate the design principles of bacterial gene sequences and how genomes encode the correct endpoints of transcription. \n\n\n\nBiography\n\n\n\nGene‑Wei Li is an Associate Professor of Biology at Massachusetts Institute of Technology (MIT) and an Investigator at Howard Hughes Medical Institute (HHMI). He earned a B.S. in Physics from National Tsinghua University (2004) and a Ph.D. in Physics from Harvard University (2010)\, followed by a postdoctoral fellowship at University of California\, San Francisco (UCSF). His research focuses on how bacterial genomes encode quantitative control over protein production — exploring how cells optimize proteome composition through precise regulation of transcription\, translation\, and RNA processing. \n\n\n\n \n\n\n\nHost; Vicente Pelechano vicent.pelechano@scilifelab.se
URL:https://www.scilifelab.se/event/how-to-terminate-transcription-at-the-right-place/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg
ORGANIZER;CN="Spotlight Seminar Series":MAILTO:events@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260127T151500
DTEND;TZID=Europe/Stockholm:20260127T161500
DTSTAMP:20260421T192248
CREATED:20260120T162312Z
LAST-MODIFIED:20260120T162331Z
UID:10001728-1769526900-1769530500@www.scilifelab.se
SUMMARY:High-Speed AFM and Cryo-EM: Dynamics and Structures of Membrane Proteins
DESCRIPTION:Simon Scheuring\n\n\n\nWeill Cornell Medicine\, USA\n\n\n\nSimon Scheuring is Distinguished Professor of Anesthesiology Research in the Department of Anesthesiology at Weill Cornell Medicine in New York\, USA. \n\n\n\nHe is a trained biologist (Biozentrum\, University of Basel\, Switzerland). During his MSc and PhD\, he learned electron microscopy (EM) and atomic force microscopy (AFM) for the structure determination of membrane proteins such as aquaporins and sugar transporters. During his postdoc and as research assistant (Institut Curie\, Paris\, France)\, he learned membrane physical chemistry and developed AFM for the study of native membranes and ventured into setting up his lab as a junior research director at the Institut Curie. Promoted to senior research director\, he built a larger laboratory in Marseille (INSERM / Aix-Marseille Université\, France). In 2017\, he moved to Weill Cornell Medicine\, where he got appointed as Professor in the Department of Anesthesiology (WCM\, New York\, USA). Simon Scheuring’s laboratory develops and applies AFM-technologies for the study of membrane phenomena\, such as membrane protein structure\, assembly\, diffusion\, and conformational dynamics of unlabeled single molecules\, bridging structure and function. Over the past years\, his laboratory has been instrumental in the development of High-Speed AFM (HS-AFM) methods\, extracting quasi-atomic structural details from single molecule AFM data\, and reaching millisecond temporal resolution for the analysis of conformational dynamics. In recent works\, his laboratory combines HS-AFM with cryo-EM to acquire an integrated understanding of the dynamics and structures of membrane proteins. \n\n\n\nAbstract\n\n\n\nHigh-speed atomic force microscopy (HS-AFM) is a powerful technique that provides dynamic movies of biomolecules at work. First\, I will briefly review our recent developments to break temporal limitations to characterize molecular dynamics by developing HS-AFM line scanning (HS-AFM-LS) and HS-AFM height spectroscopy (HS-AFM-HS) [1]\, and resolution limitations by developing Localization AFM (LAFM) [2]. Then\, I will detail how we used HS-AFM to analyze membrane-embedded TRPV3 at the single-molecule level\, and discovered a previously unobserved\, transient\, and reversible pentameric state of TRPV3\, while cryo-EM analysis allowed to resolve the first structure of a pentameric TRP channel [3\,4]. Finally\, I will report about our most recent efforts to develop and apply 3D-AFM for the characterization of the water structure on protein surfaces [5]. \n\n\n\nReferences: \n\n\n\n[1] Heath et al.\, Nature Communications\, 2018\, 9(1):4983\, High-Speed AFM Height Spectroscopy (HS-AFM-HS): Microsecond dynamics of unlabeled biomolecules. \n\n\n\n[2] Heath et al.\, Nature\, 2021\, 594(7863):385–390\, doi:10.1038/s41586-021-03551-x\, Localization Atomic Force Microscopy. \n\n\n\n[3] Lansky et al.\, Nature\, 2023\, 621(7977)\, 206–214\, doi:10.1038/s41586-023-06470-1\, A pentameric TRPV3 channel with a dilated pore. \n\n\n\n[4] Lansky et al. Nature Communications\, 2025\, 16(4520). https://doi.org/10.1038/s41467-025-59798-9\, Structural dynamics and permeability of the TRPV3 pentamer. [5] Ma et al.\, submitted\, 2025\, Aquaporins destructure water above the pore. \n\n\n\nHost: Stavros Azinas stavros.azinas@scilifelab.se
URL:https://www.scilifelab.se/event/high-speed-afm-and-cryo-em-dynamics-and-structures-of-membrane-proteins/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg
ORGANIZER;CN="Spotlight Seminar Series":MAILTO:events@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260130T120000
DTEND;TZID=Europe/Stockholm:20260130T130000
DTSTAMP:20260421T192248
CREATED:20260114T083003Z
LAST-MODIFIED:20260114T084059Z
UID:10001717-1769774400-1769778000@www.scilifelab.se
SUMMARY:Calls for new project support in Chemical Biology and Drug Discovery
DESCRIPTION:The Chemical Biology Unit (CBCS) and the Drug Discovery and Development (DDD) platform at SciLifeLab have calls out for projects. \n\n\n\nCBCS is seeking projects in Chemical Biology that include assay development for small-molecule screening and profiling\, as well as enabling chemistry.  \n\n\n\nFor more information\, please visit www.cbcs.se. \n\n\n\nThe DDD platform is looking for new project proposals for drug discovery. All therapeutic modalities that can be developed in collaboration with the DDD platform at SciLifeLab are of interest\, including small molecules\, antibodies\, oligonucleotides and new modalities. \n\n\n\nSome users and projects are at the intersection between chemical biology and drug discovery. This webinar aims to guide users to the call that best suits the needs of their project \n\n\n\nRegister here!\n\n\n\nOrganizer: the Chemical Biology Consortium Sweden and the Drug Discovery & Development platform
URL:https://www.scilifelab.se/event/calls-for-new-project-support-in-chemical-biology-and-drug-discovery-4/
LOCATION:Online event via Zoom
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260130T130000
DTEND;TZID=Europe/Stockholm:20260130T143000
DTSTAMP:20260421T192248
CREATED:20241220T095502Z
LAST-MODIFIED:20260128T152020Z
UID:10001421-1769778000-1769783400@www.scilifelab.se
SUMMARY:Information seminar on KAW/SciLifeLab Proof of Concept call for grants 2026
DESCRIPTION:The 4th call for KAW/SciLifeLab Proof of Concept grants in Life Science is open for applications! \n\n\n\nThe purpose of the Proof of Concept grant is to bridge the gap from academic research to innovations in life science. The grant gives researchers the opportunity to develop their early-stage discoveries towards validated methods\, products or processes and  provides the opportunity to carry out activities that validate and accelerate the development of the project and prepare for innovation and commercialization. \n\n\n\nWatch the seminar below to learn more about the call. ↓ \n\n\n\nRegister to the Seminar\n\n\n\nProgram\n\n\n\n13.00The KAW/SciLifeLab Proof of Concept grants in Life Science\, Olli Kallioniemi\, Professor of Molecular Precision Medicine\, KI\, Lilian Wikström\, KAW13.20Project presentation – Marie Jeansson\, KITherapeutic intervention to slow progression of chronic kidney disease13.40Project presentation – Pål Stenmark\, Stockholm UniversityInnovative therapeutic toxins for the treatment of neuromuscular disorders14.00Open discussionModerator – Isolde Palombo\, KTH\n\n\n\nApplication period\n\n\n\nCall opens: January 13\, 2026Call closes: February 20\, 2026 at 13:00 \n\n\n\nRead more about the Call
URL:https://www.scilifelab.se/event/information-seminar-on-kaw-scilifelab-proof-of-concept-call-for-grants-2026/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/12/Proof-of-Concept_bulb-in-center.png
ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se
END:VEVENT
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