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DTSTART;TZID=Europe/Stockholm:20260814T140000
DTEND;TZID=Europe/Stockholm:20260814T150000
DTSTAMP:20260806T141055Z
CREATED:20260806T141053Z
LAST-MODIFIED:20260806T141055Z
UID:10001852-1786716000-1786719600@www.scilifelab.se
SUMMARY:From Folding to Function: How Trafficking Receptors Shape Membrane Protein Biogenesis
DESCRIPTION:From Folding to Function: How Trafficking Receptors Shape Membrane Protein Biogenesis.Speaker: Prof. Simion Newstead from Oxford University \n\n\n\nMembrane proteins perform essential cellular functions\, but before they reach their final destination\, they must fold correctly and pass stringent quality control in the endoplasmic reticulum (ER). How cells coordinate membrane protein folding with selective export from the ER remains poorly understood. In this seminar\, I will discuss recent structural and mechanistic insights into the role of trafficking receptors in membrane protein biogenesis. Using cryo-electron microscopy alongside biochemical and cell-biological approaches\, we show how cornichon trafficking receptors recognise membrane-protein cargoes\, remodel the surrounding membrane\, and recruit the COPII machinery to drive ER export. These studies reveal trafficking receptors as active regulators of membrane protein maturation and provide a structural framework for understanding how membrane proteins are assembled and trafficked within the cell.
URL:https://www.scilifelab.se/event/from-folding-to-function-how-trafficking-receptors-shape-membrane-protein-biogenesis/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260817T080000
DTEND;TZID=Europe/Stockholm:20260819T170000
DTSTAMP:20260507T093224Z
CREATED:20260420T114855Z
LAST-MODIFIED:20260507T093224Z
UID:10001807-1786953600-1787158800@www.scilifelab.se
SUMMARY:4th BioSyst.EU Meeting 2026
DESCRIPTION:The 4th BioSyst EU meeting is taking place in Uppsala Sweden\, 17th – 19th August 2026\, and will be organised by the Swedish Systematics Association. The 3-day conference celebrates European systematics and biodiversity research at its origin. An excursion directly after the conference rounds off the program with keynotes and symposia.  \n\n\n\nThe Conference is supported by the KAW initiative DDLS Evolution and Biodiversity research area. Contact DDLS Fellow Tobias Andermann and the DDLS Expert Group.  \n\n\n\nThis conference will bring the European Biodiversity and Systematics community together at its Linnaean origin in Uppsala. \n\n\n\nKeynote speakers\n\n\n\nThere will be three main keynote speakers with internationally leading research profiles: Sandra Knapp\, Fredrik Ronquist and Paul Hebert. The latter is the father of DNA barcoding\, coming all the way from Canada. The journal Systematics and Biodiversity will also publish a special collection of articles arising from the conference! \n\n\n\nProgram\n\n\n\nDuring the conference\, there will be the following symposia: \n\n\n\n\nTrait Evolution\, Lineage Diversification and Historical Biogeography in a Big Data era. Confirmed speaker: Isabel Sanmartín\, Madrid.\n\n\n\nEvolution in Deep Time: Fossils\, Phylogenies\, and Reconstructing the History of Life\n\n\n\nAI and Automated Species Identification: Assets and Drawbacks\n\n\n\nAdvances in Museomics for Biosystematics and Taxonomy\n\n\n\nAre biodiversity and ecosystems the same thing?\n\n\n\nNatural History Collections and their actors\n\n\n\nTaxonomic treatments and revisions and their accessibility in biodiversity databases\n\n\n\nData-driven research in evolution and biodiversity\n\n\n\nEnvironmental DNA for species discovery and biodiversity inventory\n\n\n\nSpeciation\, Adaptation and Phylogeography: Microevolutionary Processes Shaping Biodiversity\n\n\n\nOpen session\n\n\n\n\nEarly bird before May 31\n\n\n\nRegistration is open and it costs only 1 500 SEK for students registering before 31 May (BSc\, MSc and PhD students). For everyone else the early-bird price is 2 500 SEK. \n\n\n\nEarly-career Day\n\n\n\nThere will be an early-career event the day before\, free of charge – we have two international speakers this time\, Seraina Klopfstein coming from Switzerland and Pablo Muñoz-Rodríguez coming from Spain. The early career event will be followed by some mingling and discussions\, and dinner/beers. So don’t miss out! \n\n\n\nImportant dates!\n\n\n\nAbstract submission ends 31st May 2026Early bird registration ends 31st May 2026Registration ends 17th July 2026 \n\n\n\nMore information and Registration\n\n\n\nRegistration and event website: https://www.trippus.net/BioSyst2026 \n\n\n\nAbout BioSyst EU: https://biosyst.eu/
URL:https://www.scilifelab.se/event/4th-biosyst-eu-meeting-2026/
LOCATION:Ekonomikum\, Kyrkogårdsgatan 10\, 753 12\, Uppsala
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2026/04/BioSystEU_2026_Poster_small-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260820T091000
DTEND;TZID=Europe/Stockholm:20260820T120000
DTSTAMP:20260814T125100Z
CREATED:20260813T123117Z
LAST-MODIFIED:20260814T125100Z
UID:10001856-1787217000-1787227200@www.scilifelab.se
SUMMARY:Olink Reveal: From Biomarkers to Biological Insight
DESCRIPTION:Join this morning seminar to learn how cutting-edge proteomics is accelerating biomedical research. The programme features presentations from Olink Proteomics\, SciLifeLab Clinical Genomics Gothenburg\, and researchers from the University of Gothenburg\, highlighting applications of proteomics in human biology\, machine learning\, and precision medicine. In addition\, representatives from the Proteomics Core Facility will be available to provide further research support. \n\n\n\nWelcome\, we hope to see you there! Olink Proteomics and Clinical Genomics Gothenburg \n\n\n\n\nRegistration\n\n\n\n\nAgenda\n\n\n\n09:10 – 09:15 | Welcome and introduction – Alejandro Muñoz PhD\, BusinessDevelopment Manager\, Olink Proteomics09:15 – 09:25 | Clinical Genomics Gothenburg\, from sample to data – Catarina Mörck PhD\, Service Coordinator SciLifeLab\, sequencing unit\, Sahlgrenska University Hospital09:25 – 10:00 | Accelerating Discovery with Olink Proteomics – Léocadie Henry PhD\, Field Application Scientist\, Olink Proteomics10:00 – 10:30 | Using machine learning for proteomics studies under highdimensionality – Saman Hosseini Ashtiani PhD\, Postdoctor\, Department of Clinical Neuroscience\, University of Gothenburg10:30-11:00 | Fika and mingle11:00 – 11:30 | Blood Proteomics Profiling Reveals Dynamic Programs inCardiometabolic Disease – Muhammad Arif PhD\, Associate Senior Lecturer. Department of Molecular and Clinical Medicine\, University of Gothenburg11:30 – 12:00 | Olink Reveal in Plasma Identifies Patterns of Organ Involvement in Systemic Sclerosis – Yuan Zhang PhD\, Researcher in Department of Rheumatology and Inflammation Research\, University of Gothenburg
URL:https://www.scilifelab.se/event/olink-proteomics-in-gothenburg-from-biomarkers-to-biological-insight/
LOCATION:Birgit Thilander Lecture Hall\, Academicum\, Medicinaregatan 3\, Gothenburg
CATEGORIES:Event
ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260821T100000
DTEND;TZID=Europe/Stockholm:20260821T110000
DTSTAMP:20260810T105026Z
CREATED:20260810T105025Z
LAST-MODIFIED:20260810T105026Z
UID:10001855-1787306400-1787310000@www.scilifelab.se
SUMMARY:“The times they are a-changin”*: from transparency\, to safety and scientific integrity\, how is the race to AGI changing our scientific values?
DESCRIPTION:Heidi Howard \n\n\n\nNBIS and SciLifeLab Data Centre arrange an open SciLifeLab AI Seminar Series aimed at knowledge-sharing about Artificial Intelligence and applications in the Life Science community. The seminar series is open to everyone. The seminar is run over Zoom on the third Friday of the month during academic terms\, typically between 10 and 11 am\, with approx. 45 min presentation and 15 min discussion. \n\n\n\nWhen: August 21\, 10:00-11:00 \n\n\n\nWhere:  Zoom http://meet.nbis.se/ainw \n\n\n\nSpeaker: Heidi HowardSenior Researcher\, Industrial Biotechnology\, Chalmers and ELSI lead at Scilifelab and DDLS \n\n\n\nAbstract \n\n\n\nThe general question I am currently working on is: where do values like transparency\, accountability\, scientific integrity\, replicability of science\, respect for copyright\, respect for privacy\, and respect for the planet fit into the current rush to develop Artificial General Intelligence?  \n\n\n\nIt does not take graduate work in ethics to see that in the last four years since OpenAI launched GPT-3.5 and that a number of other big and not-so-big players have spent loads of money\, time\, and GPUs/CPUs on developing large language models (LLMs\, some supposedly on their way to AGI)\,  that  these values are being eroded. Many (most?) of the decisions are being taken by a few companies holding an inordinate amount of power\, and these shifts are potentially being normalised by expert and lay publics who may not know or feel they have any influence to push against the wave of change.  Based on examples taken from past (public) work developing evaluations of large language models for bioweapons information risks and some of my current work on the public discourse around the benefits and risks of developing A(G)I\, this presentation will address scientific and ethical details that are easily overlooked in the current A(G)I rush. \n\n\n\n*song title by Dylan B/Zimmerman RA. The Times they are a-changin’\, 1964\, \n\n\n\n \n\n\n\nTo stay updated\, you can join our email list by contacting ai-network@scilifelab.se. \n\n\n\n\nJoin Seminar
URL:https://www.scilifelab.se/event/the-times-they-are-a-changin-from-transparency-to-safety-and-scientific-integrity-how-is-the-race-to-agi-changing-our-scientific-values/
LOCATION:Online event via Zoom
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260825T151500
DTEND;TZID=Europe/Stockholm:20260825T161500
DTSTAMP:20260819T150632Z
CREATED:20260817T123116Z
LAST-MODIFIED:20260819T150632Z
UID:10001859-1787670900-1787674500@www.scilifelab.se
SUMMARY:Lipid regulation of TRP channels: More than meets the eye
DESCRIPTION:For the fall’s first Spotlight seminar\, we are happy to welcome Professor Ute Hellmich from the Faculty of Chemistry and Earth Sciences\, Institute of Organic Chemistry and Macromolecular Chemistry (IOMC) at Friedrich-Schiller-Universität Jena \n\n\n\nAbstract\n\n\n\nCells rely on membrane receptors to detect and integrate diverse environmental signals. Ligands such as small molecules\, peptides or ions trigger conformational changes that regulate downstream signalling cascades. This classic\, 3D-centric view is challenged by the finding that nearly half of the human proteome is predicted to be intrinsically disordered. \n\n\n\nMany membrane receptors\, including most Transient Receptor Potential (TRP) channels\, contain large intrinsically disordered regions (IDRs) whose dynamic nature has severely hampered structural characterization. Therefore\, the contribution of IDRs to signal sensing remains poorly understood and the structural dimensions of TRP channels are notoriously underestimated. \n\n\n\nHere\, using an integrated structural biology approach\, we show that disordered channel regions contribute to multipartite signalling networks of plasma membrane and lysosomal TRP ion channels and play crucial roles in lipid-dependent functional regulation. This work thus provides a conceptual blueprint how complex membrane receptors are regulated by 
URL:https://www.scilifelab.se/event/lipid-regulation-of-trp-channels-more-than-meets-the-eye/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg
ORGANIZER;CN="Spotlight Seminar Series":MAILTO:events@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260826T150000
DTEND;TZID=Europe/Stockholm:20260826T160000
DTSTAMP:20260821T121552Z
CREATED:20260821T121204Z
LAST-MODIFIED:20260821T121552Z
UID:10001877-1787756400-1787760000@www.scilifelab.se
SUMMARY:Blueprint to Study the Entire Spatial Cellular Metabolic Landscape
DESCRIPTION:This month’s Mass Spectrometry Imaging webinar features Prof. Ramon Sun from the University of Florida College of Medicine\, USA. He will present the development of an advanced multimodal imaging approach at nanoscale resolution\, integrating techniques such as focused ion beam imaging\, helium ion microscopy\, transmission electron microscopy\, scanning probe microscopy\, and NanoSIMS. He will also showcase applications of this approach across a range of research areas. \n\n\n\n \n\n\n\n🕒 Time: 15:00–16:00 (presentation and discussion)☕ Followed by: Informal discussion with the speaker\, 16:00–16:30📍 Format: Zoom \n\n\n\n\nZoom link\n\n\n\n\nMeeting ID: 695 7569 0089Passcode: 999568 \n\n\n\nAbout the speaker\n\n\n\n\n\nProf. Ramon C. Sun holds the Anne and Oscar Lackner Endowed Chair and directs the Center for Advanced Spatial Biomolecule Research (CASBR). He is also Associate Director of Innovation at the McKnight Brain Institute. His laboratory develops mass spectrometry imaging techniques to map the metabolome\, lipidome\, and glycome from a single tissue section\, and uses machine learning to reconstruct tissue metabolism in three dimensions. \n\n\n\n \n\n\n\n\n\n \n\n\n\n\n\n\n\n\n\n\n\nSpeaker: Prof. Ramon C. Sun \n\n\n\n\n\nHis group has uncovered central roles for glycogen and protein hyper-glycosylation in Alzheimer’s disease\, cancer\, and other disorders. His work has been published in Nature Metabolism\, Nature Communications\, Cell\, and other leading journals.  \n\n\n\n \n\n\n\n\n\n\n\nUpper panel: A workflow for spatial glycomics using FFPE human brain samples.Lower panel: Spatial glycomics images demonstrating the distribution and intensity of glycans in human brain samples across Braak stages in Alzheimer’s disease (lower panels). Spatial intensity increases correlate with disease severity.” (Adopted from Figure 1\, Nat Metab 8\, 1410–1425 (2026). https://doi.org/10.1038/s42255-026-01538-4)
URL:https://www.scilifelab.se/event/blueprint-to-study-the-entire-spatial-cellular-metabolic-landscape/
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2026/08/Figure1_crop.png
LOCATION:
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260831T151500
DTEND;TZID=Europe/Stockholm:20260831T161500
DTSTAMP:20260820T073522Z
CREATED:20260817T134920Z
LAST-MODIFIED:20260820T073522Z
UID:10001861-1788189300-1788192900@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Genome-scale screens to program new T cell states for next-generation immunotherapy
DESCRIPTION:Neville Sanjana\n\n\n\nProfessor New York University\, USA \n\n\n\nBio\n\n\n\nNeville Sanjana\, PhD\, is a Core Faculty Member at the New York Genome Center and Professor of Biology\, Neuroscience and Physiology at New York University. Recent work from his lab identified synthetic cell programs to enhance cell and gene therapies and developed new methods to identify causal noncoding variants and their target genes at scale. Dr. Sanjana is a recipient of the Presidential Early Career Award for Engineers and Scientists\, AAAS Wachtel Prize for Cancer Research\, the NIH’s New Innovator Award\, the Cancer Research Institute Technology Impact Award\, the DARPA Young Faculty Award\, the Kimmel Scholar Award\, the MRA Young Investigator Award\, and also is a Leichtung Family Investigator of the Brain and Behavior Foundation. \n\n\n\nGenome-scale screens to program new T cell states for next-generation immunotherapy\n\n\n\nThe engineering of patient T-cells for adoptive cell therapies has revolutionized the treatment of several cancer types\, but further improvements are needed to increase response and cure rates. T-cell–mediated anti-tumor immunity relies on potent cytotoxic effector function\, whereas durable tumor clearance depends on stemness-driven long-term persistence. However\, endogenous T-cell differentiation programs render these phenotypes mutually exclusive: Effector maturation physiologically depletes the stem-like reservoir. Chimeric antigen receptor (CAR) T cells\, despite their impact on blood cancer treatment\, remain bound by this intrinsic biological trade-off. \n\n\n\nTo identify new genetic programs for effective cell therapy\, we overexpressed ~12\,000 barcoded human open reading frames (ORFs) and measured their impact on proliferation of primary human CD4+ and CD8+ T-cells. When overexpressed\, the top-ranked ORF\, lymphotoxin beta receptor (LTBR)\, induced profound transcriptional and epigenomic remodelling\, increasing T-cell effector functions\, as well as resistance to exhaustion in chronic stimulation settings\, via constitutive activation of the canonical NF-kB pathway. \n\n\n\nUsing this gene\, we develop a novel CAR that decouples effector differentiation from the loss of stemness. Direct fusion of the intracellular domain of the T-cell proliferation driver LTBR to the CD3ζ tail induces a shared pro-inflammatory effector program in both CD4⁺ and CD8⁺ CAR T cells. In the CD4⁺ compartment\, this effector differentiation is accompanied by an overlay of stemness-associated gene modules (TCF7 and LEF1)\, resulting in a superimposed state where pro-inflammatory and self-renewal programs coexist. This dual phenotype is dependent on the CAR configuration and is not recapitulated by LTBR co-expression. In CAR T cells engineered from diffuse large B-cell lymphoma (DLBCL) patients\, the LTBR-fusion CAR sustains tumor suppression after several rounds of repetitive tumor challenge. This lineage-specific phenotype is consistent with clinical observations linking durable remissions to persistent\, effector-competent CD4⁺ CAR T cells. Together\, our CAR engineering approach overrides canonical T cell differentiation constraints to yield dysfunction-resistant therapies\, elucidating the functional basis of lineage-specific CD4⁺ CAR T-cell responses. \n\n\n\nHost: Sanja Vickovic sanja.vickovic@scilifelab.uu.se UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-neville-sanjana/
LOCATION:BMC Room C4:305<br>\, Husargatan 3\, Uppsala\, 752 37\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
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