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X-WR-CALDESC:Events for SciLifeLab
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260825T151500
DTEND;TZID=Europe/Stockholm:20260825T161500
DTSTAMP:20260819T150632Z
CREATED:20260817T123116Z
LAST-MODIFIED:20260819T150632Z
UID:10001859-1787670900-1787674500@www.scilifelab.se
SUMMARY:Lipid regulation of TRP channels: More than meets the eye
DESCRIPTION:For the fall’s first Spotlight seminar\, we are happy to welcome Professor Ute Hellmich from the Faculty of Chemistry and Earth Sciences\, Institute of Organic Chemistry and Macromolecular Chemistry (IOMC) at Friedrich-Schiller-Universität Jena \n\n\n\nAbstract\n\n\n\nCells rely on membrane receptors to detect and integrate diverse environmental signals. Ligands such as small molecules\, peptides or ions trigger conformational changes that regulate downstream signalling cascades. This classic\, 3D-centric view is challenged by the finding that nearly half of the human proteome is predicted to be intrinsically disordered. \n\n\n\nMany membrane receptors\, including most Transient Receptor Potential (TRP) channels\, contain large intrinsically disordered regions (IDRs) whose dynamic nature has severely hampered structural characterization. Therefore\, the contribution of IDRs to signal sensing remains poorly understood and the structural dimensions of TRP channels are notoriously underestimated. \n\n\n\nHere\, using an integrated structural biology approach\, we show that disordered channel regions contribute to multipartite signalling networks of plasma membrane and lysosomal TRP ion channels and play crucial roles in lipid-dependent functional regulation. This work thus provides a conceptual blueprint how complex membrane receptors are regulated by 
URL:https://www.scilifelab.se/event/lipid-regulation-of-trp-channels-more-than-meets-the-eye/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg
ORGANIZER;CN="Spotlight Seminar Series":MAILTO:events@scilifelab.se
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DTSTART;TZID=Europe/Stockholm:20260826T150000
DTEND;TZID=Europe/Stockholm:20260826T160000
DTSTAMP:20260821T121552Z
CREATED:20260821T121204Z
LAST-MODIFIED:20260821T121552Z
UID:10001877-1787756400-1787760000@www.scilifelab.se
SUMMARY:Blueprint to Study the Entire Spatial Cellular Metabolic Landscape
DESCRIPTION:This month’s Mass Spectrometry Imaging webinar features Prof. Ramon Sun from the University of Florida College of Medicine\, USA. He will present the development of an advanced multimodal imaging approach at nanoscale resolution\, integrating techniques such as focused ion beam imaging\, helium ion microscopy\, transmission electron microscopy\, scanning probe microscopy\, and NanoSIMS. He will also showcase applications of this approach across a range of research areas. \n\n\n\n \n\n\n\n🕒 Time: 15:00–16:00 (presentation and discussion)☕ Followed by: Informal discussion with the speaker\, 16:00–16:30📍 Format: Zoom \n\n\n\n\nZoom link\n\n\n\n\nMeeting ID: 695 7569 0089Passcode: 999568 \n\n\n\nAbout the speaker\n\n\n\n\n\nProf. Ramon C. Sun holds the Anne and Oscar Lackner Endowed Chair and directs the Center for Advanced Spatial Biomolecule Research (CASBR). He is also Associate Director of Innovation at the McKnight Brain Institute. His laboratory develops mass spectrometry imaging techniques to map the metabolome\, lipidome\, and glycome from a single tissue section\, and uses machine learning to reconstruct tissue metabolism in three dimensions. \n\n\n\n \n\n\n\n\n\n \n\n\n\n\n\n\n\n\n\n\n\nSpeaker: Prof. Ramon C. Sun \n\n\n\n\n\nHis group has uncovered central roles for glycogen and protein hyper-glycosylation in Alzheimer’s disease\, cancer\, and other disorders. His work has been published in Nature Metabolism\, Nature Communications\, Cell\, and other leading journals.  \n\n\n\n \n\n\n\n\n\n\n\nUpper panel: A workflow for spatial glycomics using FFPE human brain samples.Lower panel: Spatial glycomics images demonstrating the distribution and intensity of glycans in human brain samples across Braak stages in Alzheimer’s disease (lower panels). Spatial intensity increases correlate with disease severity.” (Adopted from Figure 1\, Nat Metab 8\, 1410–1425 (2026). https://doi.org/10.1038/s42255-026-01538-4)
URL:https://www.scilifelab.se/event/blueprint-to-study-the-entire-spatial-cellular-metabolic-landscape/
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2026/08/Figure1_crop.png
LOCATION:
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DTSTART;TZID=Europe/Stockholm:20260831T151500
DTEND;TZID=Europe/Stockholm:20260831T161500
DTSTAMP:20260820T073522Z
CREATED:20260817T134920Z
LAST-MODIFIED:20260820T073522Z
UID:10001861-1788189300-1788192900@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Genome-scale screens to program new T cell states for next-generation immunotherapy
DESCRIPTION:Neville Sanjana\n\n\n\nProfessor New York University\, USA \n\n\n\nBio\n\n\n\nNeville Sanjana\, PhD\, is a Core Faculty Member at the New York Genome Center and Professor of Biology\, Neuroscience and Physiology at New York University. Recent work from his lab identified synthetic cell programs to enhance cell and gene therapies and developed new methods to identify causal noncoding variants and their target genes at scale. Dr. Sanjana is a recipient of the Presidential Early Career Award for Engineers and Scientists\, AAAS Wachtel Prize for Cancer Research\, the NIH’s New Innovator Award\, the Cancer Research Institute Technology Impact Award\, the DARPA Young Faculty Award\, the Kimmel Scholar Award\, the MRA Young Investigator Award\, and also is a Leichtung Family Investigator of the Brain and Behavior Foundation. \n\n\n\nGenome-scale screens to program new T cell states for next-generation immunotherapy\n\n\n\nThe engineering of patient T-cells for adoptive cell therapies has revolutionized the treatment of several cancer types\, but further improvements are needed to increase response and cure rates. T-cell–mediated anti-tumor immunity relies on potent cytotoxic effector function\, whereas durable tumor clearance depends on stemness-driven long-term persistence. However\, endogenous T-cell differentiation programs render these phenotypes mutually exclusive: Effector maturation physiologically depletes the stem-like reservoir. Chimeric antigen receptor (CAR) T cells\, despite their impact on blood cancer treatment\, remain bound by this intrinsic biological trade-off. \n\n\n\nTo identify new genetic programs for effective cell therapy\, we overexpressed ~12\,000 barcoded human open reading frames (ORFs) and measured their impact on proliferation of primary human CD4+ and CD8+ T-cells. When overexpressed\, the top-ranked ORF\, lymphotoxin beta receptor (LTBR)\, induced profound transcriptional and epigenomic remodelling\, increasing T-cell effector functions\, as well as resistance to exhaustion in chronic stimulation settings\, via constitutive activation of the canonical NF-kB pathway. \n\n\n\nUsing this gene\, we develop a novel CAR that decouples effector differentiation from the loss of stemness. Direct fusion of the intracellular domain of the T-cell proliferation driver LTBR to the CD3ζ tail induces a shared pro-inflammatory effector program in both CD4⁺ and CD8⁺ CAR T cells. In the CD4⁺ compartment\, this effector differentiation is accompanied by an overlay of stemness-associated gene modules (TCF7 and LEF1)\, resulting in a superimposed state where pro-inflammatory and self-renewal programs coexist. This dual phenotype is dependent on the CAR configuration and is not recapitulated by LTBR co-expression. In CAR T cells engineered from diffuse large B-cell lymphoma (DLBCL) patients\, the LTBR-fusion CAR sustains tumor suppression after several rounds of repetitive tumor challenge. This lineage-specific phenotype is consistent with clinical observations linking durable remissions to persistent\, effector-competent CD4⁺ CAR T cells. Together\, our CAR engineering approach overrides canonical T cell differentiation constraints to yield dysfunction-resistant therapies\, elucidating the functional basis of lineage-specific CD4⁺ CAR T-cell responses. \n\n\n\nHost: Sanja Vickovic sanja.vickovic@scilifelab.uu.se UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-neville-sanjana/
LOCATION:BMC Room C4:305<br>\, Husargatan 3\, Uppsala\, 752 37\, Sweden
CATEGORIES:Event
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ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
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