BEGIN:VCALENDAR VERSION:2.0 PRODID:-//SciLifeLab - ECPv6.15.18//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:https://www.scilifelab.se X-WR-CALDESC:Events for SciLifeLab REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20220327T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20221030T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20230326T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20231029T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230327T151500 DTEND;TZID=Europe/Stockholm:20230327T161500 DTSTAMP:20260407T141420 CREATED:20230302T102710Z LAST-MODIFIED:20230316T132039Z UID:10000823-1679930100-1679933700@www.scilifelab.se SUMMARY:[The Svedberg seminar] - The Underlying Cause of Human Autoimmune Disease DESCRIPTION:DAVID A. HAFLER\, MD\, FANA \n\n\n\nWilliam S. and Lois Styles Professor of Neurology and ImmunobiologyChair\, Department of Neurology\, Yale School of MedicineNeurologist-in-Chief\, Yale New Haven HospitalFounding Associate Member\, Broad Institute of MIT and Harvard \n\n\n\nBio\n\n\n\nDavid A. Hafler\, M.D. is the William S. and Lois Stiles Edgerly Professor and Chairman Department ofNeurology and Professor of Immunobiology\, Yale School of Medicine\, and is the Neurologist-in-Chiefof the Yale-New Haven Hospital. He has made seminal discoveries in the pathogenesis of multiplesclerosis and autoimmune diseases including identification of human autoreactive T cells andthe mechanisms that underlie their dysregulation with the discovery of human regulatory T cells.He led the discovery of genetic variants causing. He was awarded the Dystel Prize for MS researchand the 2023 AAI Steinman Award for Human Immunology Research. He is an Honorary Member ofthe Scandinavian Society for Immunology and has been elected to membership in the AmericanSociety of Clinical Investigation\, The Association of American Physicians\, and the National Academy of Medicine. \n\n\n\nThe Underlying Cause of Human Autoimmune Disease\n\n\n\n \n\n\n\nMultiple sclerosis (MS) is a prototypic\, genetically mediated autoimmune disease induced by environmental factors where genetic perturbation of cis-regulatory elements leads to immune dysregulation and generation of myelin reactive T cells secreting inflammatory cytokines. We have identified 233 common allelic variants associated with MS risk where approximately 60% of candidate causal variants map to enhancers and super-enhancers marked by chromatin features in T and B cells. We found that CD4+Foxp3+ Tregs are defective in MS and by performing transcriptomic and epigenomic profiling discovered that upregulation of a primate-specific short PRDM1 isoform (PRDM1-S) induces SGK1 independent from evolutionally conserved long PRDM1\, leading to destabilization of Foxp3 and Treg dysfunction. This aberrant PRDM1-S/SGK1 axis is shared among other autoimmune diseases and it is of interest that SGK-1 is induced by high salt\, an environmental risk factor in MS. Finally\, as suggested by genetic mapping\, B cells play a critical role in the disease and B cell depletion is highly effective in treating early disease. \n\n\n\nHost: Katarina Lundblad katarina.lundblad@neuro.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-the-underlying-cause-of-human-autoimmune-disease/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230328T120000 DTEND;TZID=Europe/Stockholm:20230328T130000 DTSTAMP:20260407T141420 CREATED:20230320T175356Z LAST-MODIFIED:20230320T175800Z UID:10000843-1680004800-1680008400@www.scilifelab.se SUMMARY:Towards the routine data collection from pico-gram crystals DESCRIPTION:In the frame of the “SciLifeLab Site Umeå / KBC Infrastructure Seminar Series”\, the seminars will be organised every second Tuesday during spring 2023. The seminars will be held in a hybrid format IRL in Glasburen\, KBC\, and online via Zoom. Learn more about the seminar series and Schedule for Spring 2023 here. On March 28th\, 12:00-13:00\, SciLifeLab Site Umeå / KBC Infrastructure Seminar Series presents:  \n\n\n\nTowards the routine data collection from pico-gram crystals using MicroED \n\n\n\nJohan UngeMicroED core manager and collaborator with the Gonen lab at UCLA\, Los Angeles. \n\n\n\nSign up (latest by Monday\, 27 March\, 10 a.m.) for on-site attendance to reserve your free lunch sandwich: \n\n\n\nregistration\n\n\n\nor follow online via Zoom: https://umu.zoom.us/j/63138997026 (registration is not required). \n\n\n\nAbstract: Although electron crystallography has been known almost a century\, the current success for organic and biological samples started only a decade ago. The theoretical complications from effects such as for instance dynamical scattering can be largely overcome using continuous rotation as in MicroED or cRED. Today an exponentially growing number of structures are deposited to PDB and CSD from MicroED data collections. The technique has several advantages and is a sample saving addition to the structural biology toolbox. The ability to collect a full data set from crystals 100 nm thick has allowed the structure determination of several proteins from nano sized crystals as well as small molecules directly from powder. The ability to see electrostatic potential as well as hydrogen atoms is useful for many functional studies. Recent experiences\, advantages and complications as well as newest developments towards an automatic\, accessible and efficient crystal structure determination is presented. URL:https://www.scilifelab.se/event/towards-the-routine-data-collection-from-pico-gram-crystals/ LOCATION:Glasburen Seminar Room\, Chemical Biological Centre (KBC) Building\, Umeå University\, Umeå\, 901 87\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230328T130000 DTEND;TZID=Europe/Stockholm:20230328T140000 DTSTAMP:20260407T141420 CREATED:20230228T145923Z LAST-MODIFIED:20230228T145925Z UID:10000824-1680008400-1680012000@www.scilifelab.se SUMMARY:Regulation of protein disaggregation in primates  DESCRIPTION:Cells have evolved multitiered protein quality control systems to help maintain protein homeostasis\, but under acute or chronic proteotoxic stresses\, these systems overload and result in accumulation of toxic protein aggregates. Decreased cellular capacity in aggregate clearance could trigger cell dysfunction and death leading to disease and ageing. Human cells possess an Hsp70-based disaggregase system to resolve a wide range of protein aggregates. It is not clear how these disaggregases are assembled and regulated in mammals. We report the identification of a dedicated pathway for rapidly assembling protein disaggregases during stress recovery after protein damage and outlines how aggregate clearance is orchestrated in primate cells.  URL:https://www.scilifelab.se/event/regulation-of-protein-disaggregation-in-primates/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="Cell and Molecular Imaging Platform":MAILTO:marta.carroni@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230329T090000 DTEND;TZID=Europe/Stockholm:20230330T150000 DTSTAMP:20260407T141421 CREATED:20230313T155829Z LAST-MODIFIED:20230313T161759Z UID:10000835-1680080400-1680188400@www.scilifelab.se SUMMARY:Exhibition in Navet at BMC DESCRIPTION:On March 29-30\, between 09.00-15.00\, you have the opportunity to visit an exhibition in Navet at BMC. This is a chance to receive information and updates from 20 of the leading life science companies in Sweden. \n\n\n\n\n\nCompanies present on Wednesday\, March 29\n\n\n\n\n\nCompanies present on Thursday\, March 30\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nCorning Life Sciences \n\n\n\nMeso Scale Discovery (MSD®) is a leader in high performance\, multiplex-enabled biomarker assays for cytokines\, toxicology\, neurodegeneration and metabolic disease research\, used by leading biopharmaceutical and academic researchers. \n\n\n\nNordic Biolabs is a distributing company representing around 50 different brands in Sweden\, like Promega\, Biosearch Technologies\, Cytiva and many more. We have our head office and warehouse in Täby\, Stockholm. \n\n\n\nDiscover RAMCON at the event! We specialize in a wide range from pipettes\, fermentation\, automation\, HPLC systems and cell solutions to material characterization. Join us and learn more! www.ramcon.eu \n\n\n\nRarity Bioscience was founded in 2021 to further develop the ultrasensitive multiplex superRCA assay technology – enabling full potential of liquid biopsies and radically improving cancer diagnostics. \n\n\n\nSaveen & Werner is a supplier of laboratory consumables\, reagents\, chemicals and instruments in the Nordics\, serving customers in Sweden\, Finland\, Denmark and Norway with local staff and subsidiaries. \n\n\n\nScience Imaging Scandinavia AB distributes selected Life Science Products mainly in Scandinavia and Finland. Our goal is to offer comprehensive solutions to the image related problems faced by today’s research communities. \n\n\n\nSTEMCELL Technologies provides high-quality cell culture media\, cell separation technologies\, instruments\, and educational resources to scientists around the world. Learn more at www.stemcell.com \n\n\n\n \n\n\n\nTakara Bio can offer you solutions within our wide-ranging product portfolios: NGS\, Stem cell\, Gene editing\, Genetic screening\, Cloning\, Cell biology & cell culture\, PCR\, qPCR & RT\, Transfection\, Transduction and many more \n\n\n\nTechtum Lab AB delivers smarter reagents\, consumables and instruments for customers in research and diagnostics. Wide knowledge in diagnostic microbiology\, qPCR/PCR\, digital PCR\, NGS\, extraction\, liquid handling robots and biobanking equipment. \n\n\n\n\n\nBio-Works supplies the biopharmaceutical and biotech industry with WorkBeadsTM chromatography resins and GoBio™ prepacked columns for the purification of a wide range of biomolecules such as proteins\, peptides\, oligonucleotides and mAbs. \n\n\n\nHamilton Robotics’ automated liquid handler workstations provide consistent results for assays\, ranging from low-throughput pipetting protocols to high-throughput systems with integrated sample storage. \n\n\n\nIntegrated DNA Technologies (IDT) are experts in oligo synthesis and supports NGS\, DNA amplification\, genotyping\, genome editing\, expression profiling\, synthetic biology\, and functional genomics. \n\n\n\nLabLife NordicPlease join us to discuss your research activities. Our innovative products will add to your success! Single cell sequencing\, NGS\, gene function\, proteomics\, cell assays and more! \n\n\n\nMettler Toledo (Rainin)delivers pipettes\, tips and other pipette management products that reflect our passion for exceptional quality and innovative design. They are built to deliver years of accurate\, reliable and ergonomic operation. \n\n\n\nNavinci is a Swedish biotech company that specializes in developing innovative solutions for the study of protein interactions based on our proprietary proximity ligation technology – Bringing Precision to Spatial Proteomics. \n\n\n\nNordic BioSite is recognized as a leader in supplying products for biomedical research and diagnostics throughout the Nordics. With more than 5 million products\, our portfolio represents top-quality manufacturers and suppliers. \n\n\n\nPromega mainly focus on two application areas which are genomics and bioluminescence.  Promega has served scientist in all over the world since 1978 making us pioneers within the life science industry. How can we help you?   \n\n\n\nQIAGEN delivers Sample to Insight solutions for molecular testing and offers products and services that enable our customers to gain valuable insights from any biological sample – from basic research to clinical healthcare. \n\n\n\nThermo Fisher Scientific supplies innovative solutions for the world’s leading academic institutions. We provide a broad range of products and services\, including laboratory equipment\, analytical instruments\, and reagents.  URL:https://www.scilifelab.se/event/exhibition-in-navet-at-bmc/ LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/03/Navet.jpg ORGANIZER;CN="SciLifeLab Navet":MAILTO:lokalbokning@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230331T090000 DTEND;TZID=Europe/Stockholm:20230331T093000 DTSTAMP:20260407T141421 CREATED:20230201T123912Z LAST-MODIFIED:20230223T104534Z UID:10000798-1680253200-1680255000@www.scilifelab.se SUMMARY:[Clinical Talks] Genetic Testing for a Global Community DESCRIPTION:Samuel Myllykangas\n\n\n\nBiography \n\n\n\nSamuel Myllykangas\, adjunct Professor at the Institute of Biomedicine\, University of Helsinki\, and co-founder of Blueprint Genetics. Samuel started his career by designing an entirely new method of sequencing the DNA (Oligonucleotide-Selective Sequencing) while working on his post-doctorate in the Stanford University. This method\, published in Nature\, sparked an idea of his own genetics company where he could apply his invention in the diagnostics of rare disease patients. Since then\, Samuel has built an extensive experience in developing genomics technologies\, bioinformatics tools and genetic testing solutions for rare diseases. Samuel runs Specialty Genetics at Quest Diagnostics and is the Managing Director of Blueprint Genetics. He is responsible for the overall success of the business\, leading the development and execution of strategy and delivering on financial and operational targets. \n\n\n\nBlueprint Genetics \n\n\n\nBlueprint Genetics is a genetic testing company focused on inherited diseases. With a patient-first mindset\, we deliver high-quality genetic testing to the global clinical community across 14 medical specialties. By combining a state-of-the-art laboratory process\, the latest sequencing technology\, AI empowered data-crunching tools and techniques\, world-class professionals\, and a holistic customer experience approach\, we are bringing genetic knowledge to mainstream healthcare. Blueprint supports clinicians and their patients with comprehensive and high-quality tools and resources for diagnosis of genetic conditions. In doing so\, we provide possibilities for targeted treatment and individualized care for patients. \n\n\n\n\n\n\n\n \n\n\n\nregister to receive zoom link\n\n\n\nModerator: Päivi Östling\, SciLifeLab \n\n\n\n\n\n\n\n \n\n\n\nClinical Talks\n\n\n\nClinical Talks is back for more! With a brand new and shiny Season 6. After successfully completing 5 seasons with > 70 enthusiastic Clinical Talkers to our record\, we have barely scratched the surface of all the amazing work our clinical\, academic and industry Life Science community has to offer. More about the upcoming events is available here. \n\n\n\nThese events are co-organized by Karolinska Institutet Innovations AB and SciLifeLab\, together with Colibri Ventures. URL:https://www.scilifelab.se/event/clinical-talks-genetic-testing-for-a-global-community/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/08/Square-500x500-Clinical-Talks@4x.png ORGANIZER;CN="Clinical Talks":MAILTO:precisionmedicine@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230417T090000 DTEND;TZID=Europe/Stockholm:20230417T170000 DTSTAMP:20260407T141421 CREATED:20230209T071629Z LAST-MODIFIED:20230329T110957Z UID:10000807-1681722000-1681750800@www.scilifelab.se SUMMARY:SciLifeLab Day Gothenburg DESCRIPTION:This event is a kick-off for the national SciLIfeLab site in Gothenburg. Learn more about the services and capabilities that are offered from SciLifeLab\, both nationally and locally\, and how you can participate in the activities! \n\n\n\nThe Gothenburg Site of SciLifeLab is happy to welcome the research community in Gothenburg and beyond to this kick-off. Meet with the established site\, researchers\, local and national infrastructures; interact with the SciLifeLab capabilities\, Precision Medicine\, Pandemic Laboratory Preparedness and Planetary Biology; learn about the Data Centre services and the Data Driven Life Science program and much more. \n\n\n\nRead more\n\n\n\nsign up here\n\n\n\nContact\n\n\n\n\n\ngothenburg@scilifelab.se \n\n\n\n\n\nMaria SmedhSciLifeLab GothenburgSite Coordinatormaria.smedh@gu.se 0766-229712\n\n\n\n\n\nSciLifeLab Days on the other sites\n\n\n\n\nGothenburg\, April 17\n\n\n\nUmeå\, September 11\n\n\n\nLund\, September 28\n\n\n\nLinköping\, October 10 URL:https://www.scilifelab.se/event/scilifelab-day-gothenburg/ LOCATION:Conference Centre Wallenberg\, Medicinaregatan 20A\, Gothenburg\, 413 90\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/02/Gothenburg-SciLifeLab-Days-Registration-Open.png ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230418T090000 DTEND;TZID=Europe/Stockholm:20230418T120000 DTSTAMP:20260407T141421 CREATED:20230412T073931Z LAST-MODIFIED:20230412T074007Z UID:10000853-1681808400-1681819200@www.scilifelab.se SUMMARY:EIRENE Sweden Symposium on the Exposome DESCRIPTION:This half-day symposium at SciLifeLab is hosted by Stockholm University and the National Facility for Exposomics at SciLifeLab\, with the goal to increase scientific dialogue on the exposome\, and to share perspectives on development of European infrastructure to support large scale exposomics. \n\n\n\nPresentations will feature prominent figures in the exposomics field\, including keynote lectures from leadership and international collaborators of EIRENE (Environmental Exposure Assessment Research Infrastructure)\, which is the first EU infrastructure (ESFRI Roadmap 2021) dedicated to human exposome research. \n\n\n\nZoom Link for Remote Participants: https://stockholmuniversity.zoom.us/j/63852683962 \n\n\n\nTime Speaker\, Affiliation Title  Session 1\, Chaired by Jonathan Martin\, Stockholm University 9:00-9:10 Åke Bergman\, Örebro University Introductory Remarks\, EIRENE Sweden 9:10-9:40 Jana Klánová\, Masaryk University EIRENE: What is needed to fill a gap in the ESFRI landscape? 9:40-10:00 Roxana Merino Martinez\, Karolinska InstitutetHEAP: Human Exposome Assessment Platform 10:00-10:30 Robert Barouki\, Université de Paris Exposome and Toxicology 10:30-10:50 Coffee Break\, Sponsored by ThermoFisher Scientific  Session 2: Chaired by Craig Wheelock\, Karolinska Institutet10:50-11:10 Tuulia Hyötyläinen\, Örebro University Sex-specific effects of environmental exposure as contributor to initiation and progression to non-alcoholic fatty liver disease 11:10-11:40 Roel Vermeulen\, Utrecht University Observations from The EXPANSE and EXPSOME-NL project 11:40-12:00 Jonathan Martin\, Stockholm University Chemical exposomics in people and the environment End of Programme (lunch for those interested) URL:https://www.scilifelab.se/event/eirene-sweden-symposium-on-the-exposome/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="National Facility for Exposomics":MAILTO:jon.martin@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230418T120000 DTEND;TZID=Europe/Stockholm:20230418T130000 DTSTAMP:20260407T141421 CREATED:20230411T093123Z LAST-MODIFIED:20230411T093124Z UID:10000852-1681819200-1681822800@www.scilifelab.se SUMMARY:BICU and Biomolecule Characterization Unit DESCRIPTION:In the frame of the “SciLifeLab Site Umeå / KBC Infrastructure Seminar Series”\, the seminars will be organised every second Tuesday during spring 2023. The seminars will be held in a hybrid format IRL in Glasburen\, KBC\, and online via Zoom. Learn more about the seminar series and Schedule for Spring 2023 here. \n\n\n\nOn April 18th\, 12:00-13:00\, SciLifeLab Site Umeå / KBC Infrastructure Seminar Series presents: \n\n\n\nBiochemical Imaging Centre Umeå and Biomolecule Characterization Unit. What is new? What is next?\n\n\n\nby  \n\n\n\nIrene Martinez Carrasco \n\n\n\nBICU facility manager and Senior research engineer at the Department of Medical Biochemistry and Biophysics\, Department of Integrative Medical Biology (IMB) \n\n\n\nJohan Olofsson Edlund \n\n\n\nResearch engineer at the Department of Medical Biochemistry and Biophysics \n\n\n\nand \n\n\n\nFouzia Bano \n\n\n\nSenior research engineer at the Department of Clinical Microbiology \n\n\n\nSign up (latest by Monday\, 17 April\, 10 a.m.) for on-site attendance to reserve your free lunch sandwich. \n\n\n\nRead more\n\n\n\nAbstract: \n\n\n\nDuring the seminar\, we will present the latest news at The Biochemical Imaging Centre Umeå (BICU) and a new emerging facility: The Biomolecule Characterization Unit (BMCU). \n\n\n\nThe Biochemical Imaging Centre Umeå (BICU) is an open-access imaging centre that provides state-of-the-art microscopy technology to researchers all over Sweden. We provide access and training to a wide range of instruments and techniques\, including widefield\, confocal\, spinning disc\, Tirf microscopy\, FLIM\, FLIM-FRET\, FRAP and super-resolution microscopy on live cells for an optimal spatial and temporal resolution. Furthermore\, the centre provides access to atomic force microscopy (AFM) to generate topographical images and measure mechanical properties of samples. \n\n\n\nAt The Biomolecule Characterization Unit\, we offer a comprehensive suite of cutting-edge technologies to help you gain a deeper understanding of molecular interactions and biomolecular structures. Our platform features state-of-the-art SPR\, ITC\, CD\, and QCMD technologies\, which provide complementary information on biomolecular interactions\, thermodynamics\, kinetics\, and structural characterization. URL:https://www.scilifelab.se/event/bicu-and-biomolecule-characterization-unit/ LOCATION:Glasburen Seminar Room\, Chemical Biological Centre (KBC) Building\, Umeå University\, Umeå\, 901 87\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230420T140000 DTEND;TZID=Europe/Stockholm:20230420T160000 DTSTAMP:20260407T141421 CREATED:20230331T082931Z LAST-MODIFIED:20230331T083027Z UID:10000847-1681999200-1682006400@www.scilifelab.se SUMMARY:Unleashing the Power of Single-Cell Multi-Modal Analysis DESCRIPTION:Join Mission Bio for an interactive session about the latest advances and applications of single-cell technologies. We will start with a 1h overview on the following topics: \n\n\n\n\nTechnology overview & applications\n\n\n\nSingle cell MRD-detection with higher detection sensitivity\n\n\n\nCAR-T: treatment studies and quality control\n\n\n\nSingle-cell DNA-metylation in hematological malignancies\n\n\n\nClonal tumor profiling in solid tumor\n\n\n\n\nThe 2nd part will be an open forum to discuss applications\, protocols\, experimental planning and pipeline overview. \n\n\n\nSpeaker\n\n\n\nSimone Formisano is Technical Application Liaison at Mission Bio. He obtained his Master’s Degree in Biotechnology at Columbia University\, New York City (United States). Before joining Mission Bio in 2022\, Simone completed his Doctorate experimental work in cancer immunotherapy at Ludwig Maximilian University of Munich. Afterward\, he contributed to the clinical development of several therapies in solid oncology by joining Daiichi Sankyo as a Medical Science Liaison. \n\n\n\nContact\n\n\n\nIda Höijer (ida.hoijer@scilifelab.uu.se)Malin Melin (malin.melin@scilifelab.uu.se) URL:https://www.scilifelab.se/event/unleashing-the-power-of-single-cell-multi-modal-analysis/ LOCATION:Room Waldenström\, Rudbeck Laboratory\, Dag Hammarskjölds Väg 20\, Uppsala\, 752 37\, Sweden CATEGORIES:Event ORGANIZER;CN="Clinical Genomics Uppsala":MAILTO:clinicalgenomicsuppsala@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230421T090000 DTEND;TZID=Europe/Stockholm:20230421T093000 DTSTAMP:20260407T141421 CREATED:20230201T124434Z LAST-MODIFIED:20230223T104655Z UID:10000799-1682067600-1682069400@www.scilifelab.se SUMMARY:[Clinical Talks] Molecular Pixelation: unlocking the power of single cell proteomics DESCRIPTION:Alvaro Martinez Barrio and Filip Karlsson\n\n\n\n\n\n\n\nÁlvaro Martinez BarrioÁlvaro brings 15+ year in the computational biology field to Pixelgen. He has worked in NGS tech/analysis for over 10 years. Before Pixelgen Álvaro was a single-cell expert and group leader at 10X Genomics. Álvaro is one of the co-founders of Pixelgen Technologies. \n\n\n\n \n\n\n\n\n\n\n\nFilip KarlssonFilip has 10+ years of track record of product development in biotech start-ups using RCA with SureSelect (Halo Genomics now Agilent) and Vanadis NIPT (PerkinElmer). He is the co-inventor of Molecular Pixelation and one of the co-founders of Pixelgen Technologies. \n\n\n\nPixelgen Technologies \n\n\n\nPixelgen Technologies AB was founded in 2020 by a team of passionate\, experienced innovators and entrepreneurs with a vision to bring a new spatial understanding to biology by mapping cell surface proteins and their spatial inter-relationships. The company has developed Molecular Pixelation\, a DNA-based visualization technology for analyzing cell surface proteins\, to gain novel insights into cellular activity that will advance better medicines and diagnostics. Pixelgen is headquartered in Stockholm\, Sweden. \n\n\n\n \n\n\n\nregister to receive zoom link\n\n\n\nModerator: Michael Akhras and Päivi Östling \n\n\n\n\n\n\n\n \n\n\n\nClinical Talks\n\n\n\nClinical Talks is back for more! With a brand new and shiny Season 6. After successfully completing 5 seasons with > 70 enthusiastic Clinical Talkers to our record\, we have barely scratched the surface of all the amazing work our clinical\, academic and industry Life Science community has to offer. More about the upcoming events is available here. \n\n\n\nThese events are co-organized by Karolinska Institutet Innovations AB and SciLifeLab\, together with Colibri Ventures. URL:https://www.scilifelab.se/event/clinical-talks-molecular-pixelation/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/08/Square-500x500-Clinical-Talks@4x.png ORGANIZER;CN="Clinical Talks":MAILTO:precisionmedicine@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230424T123000 DTEND;TZID=Europe/Stockholm:20230425T143000 DTSTAMP:20260407T141421 CREATED:20230301T152415Z LAST-MODIFIED:20230412T152145Z UID:10000825-1682339400-1682433000@www.scilifelab.se SUMMARY:Three Decades of Genomics:  From PCR to Precision Medicine DESCRIPTION:Ann-Christine Syvänen moved from Helsinki\, Finland to Uppsala in 1998. In 2001 she was appointed professor in Molecular Medicine at the Department of Medical Sciences at Uppsala University. After 20 years as a research group leader and director of the SNP&SEQ Technology Platform\, followed by five years as senior professor at Uppsala University\, she retired in 2022. This open symposium brings together her former colleagues from Finland\, as well as coworkers and former students in Uppsala to celebrate the progress in Human Genomics during the past three decades and future prospects for Genomics in Precision Medicine. \n\n\n\n\n\n\nOrganizers: Ann-Christine Syvänen\, Jessica Nordlund\, Ulrika Liljedahl \n\n\n\nContact for questions: Ulrika Liljedahl\, Ulrika.Liljedahl@medsci.uu.se \n\n\n\n\n\n\n\n\n\n\n\n\nRegistration\n\n\n\nRegistration is mandatory\, deadline April 17\, 2023 \n\n\n\nRegister here\n\n\n\n\n\n\n\nThis event is sponsored by: \n\n\n\n\n\n\n\n\n\nKAW\n\n\n\n\n\nSciLifeLab\n\n\n\n\n\nNavinci\n\n\n\n\n\nNGI\n\n\n\n\n\n\n\n\n\nProgram overview\n\n\n\nFull program\, printable Pdf \n\n\n\n \n\n\n\nDay 1\, Monday April 24\, 2023\n\n\n\n12.30-14.30 Session I: First decade of genomics\, and before. Chair Ann-Christine Syvänen \n\n\n\nAnn-Christine Syvänen\, Prof. em. Dept of Medical Sciences\, Uppsala University\, Sweden \n\n\n\nHans Söderlund\, Prof. em. Technical Research Centre of Finland (VTT) \n\n\n\nAntti Sajantila\, Dept of Forensic Medicine\, University of Helsinki\, Finland \n\n\n\nAarno Palotie\, The Broad Institute of MIT and Harvard\, Cambridge\, USA & Institute for Molecular Medicine\, (FIMM)\, University of Helsinki\, Finland \n\n\n\n15.00-17.00 Session II: Disease genetics and genomics. Chair Jessica Nordlund \n\n\n\nIvo Gut\, Centro Nacional de Analisis Genomico\, Barcelona\, Spain \n\n\n\nLars Rönnblom\, Dept of Medical Sciences\, Uppsala University\, Sweden \n\n\n\nGunnel Nordmark \, Dept of Medical Sciences\, Uppsala University\, Sweden \n\n\n\nTuuli Lappalainen\, New York Genome Centre\, USA\, SciLifeLab and KTH Royal Institute of Technology\, Stockholm\, Sweden \n\n\n\n\n\n\n\nDay 2\, Tuesday April 25\, 2023\n\n\n\n9.30-11.30 Session III: Translational genomics and drug development. Chair Gunnel Nordmark \n\n\n\nOlli Kallioniemi\, SciLifeLab and Dept of Oncology & Pathology\, Karolinska Institutet\, Stockholm\, Sweden \n\n\n\nAnna Kiialainen\, Genentech Research and Early Development\, Hoffmann-La Roche\, Basel\, Switzerland \n\n\n\nMaria Lagerström\, Biopharmaceuticals R&D\, AstraZeneca \n\n\n\nJessica Nordlund\, Dept of Medical Sciences\, Uppsala University\, Sweden \n\n\n\nHåkan Melhus\, Dept of Medical Sciences\, Uppsala University\, Sweden \n\n\n\n12.30-14.30 Session IV: Genomics technology: past\, present and future. Chair Lars Feuk \n\n\n\nUlf Landegren\, Dept of Immunology\, Genetics and Pathology Uppsala University\, Sweden \n\n\n\nElin Grundberg\, Children’s Mercy Hospital and University of Missouri\, Kansas City\, USA \n\n\n\nMats Nilsson\, SciLifeLab and Dept of Biochemistry and Biophysics\, Stockholm University \n\n\n\nDavid Klenerman\, University of Cambridge\, United Kingdom \n\n\n\nAnn-Christine Syvänen\, Prof. em. Dept of Medical Sciences\, Uppsala University\, Sweden URL:https://www.scilifelab.se/event/three-decades-of-genomics-from-pcr-to-precision-medicine/ LOCATION:BMC\, The Svedberg Lecture Hall (B8)\, Husargatan 3\, Uppsala\, 752 37\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/03/ResearchLogo-002-e1677683793531.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230424T151500 DTEND;TZID=Europe/Stockholm:20230424T161500 DTSTAMP:20260407T141421 CREATED:20230331T130042Z LAST-MODIFIED:20230331T130044Z UID:10000848-1682349300-1682352900@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Copy-Number Changes During Experimental Evolution in Caenorhabditis elegans: Rate\, Fitness Effects and Context-Dependence DESCRIPTION:VAISHALI KATJU \, Professor \n\n\n\nProgram in Evolutionary Biology \n\n\n\nDepartment of Ecology & Genetics \n\n\n\nUppsala University \n\n\n\n\n\n\n\n\n\n\n\nBio\n\n\n\nProf. Katju is an evolutionary geneticist whose research combines the power of experimental evolution with the model nematode C. elegans and high-throughput genomics to address fundamental questions in biology and evolution regards the rates\, fitness effects and evolutionary dynamics of spontaneous mutations. Her current and future research program is focused on investigating (i) the consequences of spontaneous mutation under varying intensity of selection\, (ii)mitochondrial evolution and the genetic architecture of mitonuclear interactions and (iii) the transcriptional and functional consequences of copy-number changes during adaptation. \n\n\n\nD. Katju earned her Ph.D. in Evolutionary Genetics from Indiana University-Bloomington\, USA in 2004 under the supervision of Dr. Michael Lynch. Following the completion of a National Science Foundation funded Postdoctoral Research Fellowship in Biological Informatics\, she served as a faculty member (Assistant and Associate Professor) in the Department of Biology at the University of New Mexico from 2007-2015. From 2015-2022\, she was a faculty member (Associate and full Professor) in the Department of Veterinary Integrative Biosciences in the College of Veterinary Medicine at Texas A&M University. In 2022\, she joined the Department of Ecology and Genetics at Uppsala University as a Professor. \n\n\n\n \n\n\n\nCopy-Number Changes During Experimental Evolution in Caenorhabditis elegans: Rate\, Fitness Effects and Context-Dependence\n\n\n\n \n\n\n\nThe genomic era has revealed that gene copy-number differences due to gene duplications and deletions are rampant in natural populations. Yet\, base substitutions as a mutational class have dominated the field of evolutionary biology as the main contributor to genetic variation leading to evolution. Herein\, I briefly explore the history of the field\, from the neo-Darwinian synthesis through Ohno’s canonical model for the evolution of gene duplicates and its failure to encapsulate the full complexity of the duplication process. Lastly\, I present results from three long-term experimental evolution experiments in Caenorhabditis elegans that investigate fundamental properties of copy-number variants (CNVs)\, including (i) direct estimates of their rates of origin\, (ii) evidence that CNVs constitute a common mechanism of adaptive genetic change during compensatory evolution\, and (iii) evidence that duplications and deletions of highly transcribed genes are detrimental to fitness and a role for selection against an increase in transcript abundance. \n\n\n\nHost: Leif Andersson leif.andersson@imbim.uu.se UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-copy-number-changes-during-experimental-evolution-in-caenorhabditis-elegans-rate-fitness-effects-and-context-dependence/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230425T150000 DTEND;TZID=Europe/Stockholm:20230425T180000 DTSTAMP:20260407T141421 CREATED:20230316T092531Z LAST-MODIFIED:20230420T064935Z UID:10000837-1682434800-1682445600@www.scilifelab.se SUMMARY:Opening of Coalescence; Scientific research through an artist’s lens DESCRIPTION:Welcome to the opening of the exhibition Coalescence; Scientific research through an artist’s lens at SciLifeLab’s Solna campus. \n\n\n\nThe exhibition will feature work by 16 artists from the Royal Institute of Art\, created in individual collaborations with 33 researchers from SciLifeLab. \n\n\n\nThe collaborations were set up as a new program at SciLifelab\, started by SciLifeLab researcher Max Frankel\, to connect the artistic and scientific communities in Stockholm. \n\n\n\nThere will be temporary artwork\, talks\, and drinks both in Air&Fire and in the Delta lobby. The exhibition in the Delta lobby is open to the public during SciLifeLab’s typical hours\, from April 26th until May 8th. \n\n\n\n \n\n\n\nPlease register if you’d like to attend the opening. The event is free of charge. \n\n\n\nRegistration\n\n\n\nNews: Scientific research through an artist’s lens – first meeting URL:https://www.scilifelab.se/event/opening-of-coalescence-scientific-research-through-an-artists-lens/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230427T080000 DTEND;TZID=Europe/Stockholm:20230428T170000 DTSTAMP:20260407T141421 CREATED:20230331T125157Z LAST-MODIFIED:20230331T125455Z UID:10000849-1682582400-1682701200@www.scilifelab.se SUMMARY:Nordic Precision Medicine Forum DESCRIPTION:Following the success over the past 6 year of our annual Nordic Precision Medicine Forum we are excited to announce that in 2023 we have a new venue and TWO NEW EVENTS. This allows us to convene a broader group of experts\, from more disciplines\, across all of the key stakeholders\, in one place. \n\n\n\nAs Precision Medicine initiatives around the world gather pace\, the Nordic countries are in an enviable position when it comes to joining all the dots. The link between digital health\, omics technologies\, artificial intelligence and data means that yet more collaboration is required to ensure the success of precision medicine. As demonstrated by organisations such as SciLifeLab\, the collaborative efforts of healthcare\, research\, industry and patient organisations is really starting to bear fruit. \n\n\n\nThe lines between the different disciplines involved in precision medicine are often blurred\, so to bring all of the people together we have created three unique meetings which allow our attendees to move freely between different areas of interest. \n\n\n\nThrough a combination of keynotes\, presentations\, panel discussions\, breakouts and networking opportunities\, you will have access to those who are shaping the digital health revolutions across the region\, under one roof\, over two days. \n\n\n\nPlacing all the experts from the Precision Medicine ecosystem in one place at one time allows for the very essence of what many say is the key to precision medicine – collaboration. We look forward to seeing you in Stockholm on 27-28 April 2023. \n\n\n\nRead more\n\n\n\nWe very much hope to see you in Stockholm in April 2023! URL:https://www.scilifelab.se/event/nordic-precision-medicine-forum-2/ LOCATION:München Bryggeriet\, Torkel Knutssongatan 2\, Stockholm\, 11825\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230427T150000 DTEND;TZID=Europe/Stockholm:20230427T170000 DTSTAMP:20260407T141421 CREATED:20230317T102909Z LAST-MODIFIED:20230317T113319Z UID:10000840-1682607600-1682614800@www.scilifelab.se SUMMARY:Matchmaking Event: Data Science and Medical/Clinical/Healthcare Research Project Call 2024 DESCRIPTION:Welcome to a matchmaking in SciLifeLab between Data Science and Medical/Clinical/Healthcare research at Karolinska Institutet\, KTH and Region Stockholm\, related to the Health\, Medicine and Technology (HMT) Project Call 2024 (opens on 13 April). Following the success of the event last year we invite you to participate in another matchmaking event to find research partners for the upcoming call. A key requirement to apply is that one partner is from KTH and one from Region Stockholm.  \n\n\n\nRead more URL:https://www.scilifelab.se/event/matchmaking-event-data-science-and-medical-clinical-healthcare-research-project-call-2024/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2020/02/kth_logotyp_pms_2013.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230502T080000 DTEND;TZID=Europe/Stockholm:20230502T170000 DTSTAMP:20260407T141421 CREATED:20230421T081435Z LAST-MODIFIED:20230421T081436Z UID:10000865-1683014400-1683046800@www.scilifelab.se SUMMARY:FIB-SEM - Imaging and Micro-manipulation DESCRIPTION:In the frame of the “SciLifeLab Site Umeå / KBC Infrastructure Seminar Series”\, the seminars will be organised every second Tuesday during spring 2023. The seminars will be held in a hybrid format IRL in Glasburen\, KBC\, and online via Zoom. Learn more about the seminar series and Schedule for Spring 2023 here. \n\n\n\nOn May 2nd\, 12:00-13:00\, SciLifeLab Site Umeå / KBC Infrastructure Seminar Series presents: \n\n\n\nFIB-SEM – Imaging and Micro-manipulation\n\n\n\nby  \n\n\n\nSara Henriksson\, Umeå Centre for Electron Microscopy (UCEM)\, Head of TEM unit\, Facility manager\, SciLifeLab contact for FIB-SEM  \n\n\n\nand \n\n\n\nCheng Choo Lee (Nikki)\, Umeå Centre for Electron Microscopy (UCEM)\, Head of SEM unit\, Facility manager \n\n\n\nRead more URL:https://www.scilifelab.se/event/fib-sem-imaging-and-micro-manipulation/ LOCATION:Glasburen Seminar Room\, Chemical Biological Centre (KBC) Building\, Umeå University\, Umeå\, 901 87\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230502T080000 DTEND;TZID=Europe/Stockholm:20230502T170000 DTSTAMP:20260407T141421 CREATED:20230504T123021Z LAST-MODIFIED:20230508T072522Z UID:10000880-1683014400-1683046800@www.scilifelab.se SUMMARY:NBIS and CASP - feeling lost in data? We are here to help DESCRIPTION:In the frame of the “SciLifeLab Site Umeå / KBC Infrastructure Seminar Series”\, the seminars will be organised every second Tuesday during spring 2023. The seminars will be held in a hybrid format IRL in Glasburen\, KBC\, and online via Zoom. Learn more about the seminar series and Schedule for Spring 2023 here. \n\n\n\nOn May 16th\, 12:00-13:00\, SciLifeLab Site Umeå / KBC Infrastructure Seminar Series presents: \n\n\n\nNBIS and CASP – feeling lost in data? We are here to help! \n\n\n\nby  \n\n\n\nJeanette Tångrot\, NBIS expert and Senior research engineer at the Department of Molecular Biology \n\n\n\nand \n\n\n\nKate Bennett\, CASP platform manager and Research coordinator at the Department of Chemistry \n\n\n\n\nSign up (latest by Monday\, 15 May\, 10 a.m.) for on-site attendance to reserve your free lunch sandwich: \n\n\n\nRegister\n\n\n\nor follow online via Zoom: https://umu.zoom.us/j/63138997026 (registration is not required). \n\n\n\n\nAbstract: \n\n\n\nThe Computational Analytics Support Platform (CASP) is a data analytics service at Umeå University\, while the National Bioinformatics Infrastructure Sweden (NBIS) is a distributed national research infrastructure providing bioinformatics support\, infrastructure and training. In this seminar\, we will describe the different types of services provided by both CASP and NBIS\, helping researchers make the most out of their data. \n\n\n\nCASP is a co-funded KBC infrastructure that primarily supports\, but also trains life scientists in the analysis of experimental data using advanced data-driven tools and strategies. We focus on the analysis of data from a wide range of technologies including\, but not limited to\, downstream omics (metabolomics/proteomics)\, spectroscopy and imaging. Since the platform was launched in 2021\, CASP has supported multiple researchers across departments and faculties convert complex data into meaningful biological and chemical interpretations. \n\n\n\nNBIS is the SciLifeLab bioinformatics platform and the Swedish node in ELIXIR. NBIS has staff at six sites\, including Umeå. We provide expertise in most areas of bioinformatics\, including omics analysis\, genome assembly/annotation\, image analysis and biostatistics. We provide weekly online drop-in sessions and free consultation meetings\, as well as hands-on project support ranging from assistance with smaller tasks to long-term engagement. We also offer support in data management and systems development\, such as tools\, pipelines\, and interactive websites. In addition\, we provide both introductory and advanced training events. \n\n\n\n\nMore information about CASP: https://www.umu.se/en/research/infrastructure/computational-analytics-support-platform-casp/ \n\n\n\n NBIS: https://nbis.se/ \n\n\n\n\nRead more URL:https://www.scilifelab.se/event/nbis-and-casp-feeling-lost-in-data-we-are-here-to-help/ LOCATION:Glasburen Seminar Room\, Chemical Biological Centre (KBC) Building\, Umeå University\, Umeå\, 901 87\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230505T130000 DTEND;TZID=Europe/Stockholm:20230505T150000 DTSTAMP:20260407T141421 CREATED:20230420T160433Z LAST-MODIFIED:20230420T160437Z UID:10000863-1683291600-1683298800@www.scilifelab.se SUMMARY:MethylR - From Sequencer to Publication DESCRIPTION:Join and learn how to use methylR\, a new online tool from Clinical Genomics Linköping and Bioinformatics\, Core Facility\, Linköping University for methylation data analysis. \n\n\n\nMassimiliano Volpe\, Ph.D\, Jyotirmoy Das\, Ph.D\, methylR: a graphical interface for comprehensive DNA methylation array data analysis\, Bioinformatics\, 2023;\, btad184. \n\n\n\nRead more\n\n\n\nmethylR_flyer_3Download URL:https://www.scilifelab.se/event/methylr-from-sequencer-to-publication/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2020/05/AdobeStock_297709311-scaled.jpeg ORGANIZER;CN="Clinical Genomics Link%C3%B6ping":MAILTO:tobias.strid@liu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230508T151500 DTEND;TZID=Europe/Stockholm:20230508T161500 DTSTAMP:20260407T141421 CREATED:20230412T095910Z LAST-MODIFIED:20230414T114147Z UID:10000854-1683558900-1683562500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Global mapping of protein subcellular location offers a new era of comparative and evolutionary cell biology. DESCRIPTION:Ross Waller \, Professor of Evolutionary Cell Biology \n\n\n\n Department of Biochemistry \n\n\n\nUniversity of Cambridge\, UK \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nRoss Waller completed a PhD in 2000 at the University of Melbourne working on the newly discovered remnant plastid in apicomplexan parasites Plasmodium and Toxoplasma. He undertook postdoctoral training from 2000-3 as a Peter Doherty Fellow working on Leishmania cell biology (University of Melbourne)\, and then from 2003-5 as a Canadian Institutes of Health Research working on molecular evolution in diverse eukaryotes at the University of British Columbia. In 2005 be joined the faculty of the School of Botany\, University of Melbourne\, and in 2013 relocated his laboratory to the Department of Biochemistry\, University of Cambridge. \n\n\n\n \n\n\n\nGlobal mapping of protein subcellular location offers a new era of comparative and evolutionary cell biology\n\n\n\nMost of the diversity of eukaryotic life is represented by unicellular organisms\, and most of this has diverged from well-studied model organisms by over a billion years of evolution. Consequently\, while core eukaryotic cellular and molecular biology is often conserved\, this represents only a small fraction of the molecular diversity\, organisation\, and function of most cells. This\, in turn\, severely constrains our ability to infer the biology of most of eukaryotic life from the better-studied models such as animals and fungi. To address the need for de novo characterisation of cells’ molecular diversity we use a spatial proteomics method called LOPIT that simultaneously captures the steady-state subcellular locations of thousands of proteins. We use these new cellular blueprints as springboards to study the evolutionary processes\, adaptations and trajectories that have contributed to eukaryotic cell diversity\, with particular focus on understanding the apicomplexan parasites and their close algal relatives the dinoflagellates. \n\n\n\n \n\n\n\nHost: Fabien Burki\, UU fabien.burki@ebc.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-global-mapping-of-protein-subcellular-location/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230509T080000 DTEND;TZID=Europe/Stockholm:20230511T170000 DTSTAMP:20260407T141421 CREATED:20230413T131100Z LAST-MODIFIED:20230413T131140Z UID:10000857-1683619200-1683824400@www.scilifelab.se SUMMARY:European Chemical Biology Symposium DESCRIPTION:The free event will combine ELRIG’s inaugural meeting on Therapeutic OLIGOs with the 8th European Chemical Biology Symposium (ECBS) and will be held in Gothenburg\, Sweden from May 9–11. Over the three days\, academia\, industry\, and the vendor community will discuss recent advancements in two ultra-exciting areas of drug discovery and biological research: therapeutic oligonucleotides and chemical biology. \n\n\n\nSpeakers range from breakthrough therapeutic oligo pioneer Frank Bennet\, to the vastly experienced Marie Vikstrom Lindholm of Silence Therapeutics. \n\n\n\nKeynote speakers\n\n\n\nFrank Bennett\, Katherine Donovan\, Steven Dowdy\, Marie Wikstrom Lindholm and Shantanu Singh. \n\n\n\nPresenters\n\n\n\nPetr Bartunek\, Tom Brown\, Peter Crowley\, Samir EL Andaloussi\, Simon Elsässer\, Alice Ghidini\, Aurelie Goyenvalle\, Peter Hagedorn\, Emma Kay\, Stefan Kubicek\, Michael Kurczy\, Pär Matsson\, Cristina Mayor-Ruiz\, Rui Moreira\, Sílvia Osuna\, Andrea Rentmeister\, Chiara Saponaro\, Sabine Sewing. \n\n\n\nRead more URL:https://www.scilifelab.se/event/european-chemical-biology-symposium/ LOCATION:AstraZeneca\, PGN Entrance\, Pepparedsleden 5\, Mölndal\, 431 53 CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230511T100000 DTEND;TZID=Europe/Stockholm:20230511T130000 DTSTAMP:20260407T141421 CREATED:20230502T074324Z LAST-MODIFIED:20230502T074954Z UID:10000875-1683799200-1683810000@www.scilifelab.se SUMMARY:Start discovering with Xenium DESCRIPTION:Introducing high-performance subcellular spatial profiling made easy with Xenium In Situ. The Xenium platform reveals new insights into cellular structure and function by performing high-throughput mapping of hundreds of RNA targets in their true tissue context. The platform includes a versatile and easy-to-use instrument\, sensitive and specific chemistry\, a diverse menu of customizable panels\, and powerful visualization software. \n\n\n\n\n\nProgram\n\n\n\n9.30Registration10.00Welcome & ISS platform services\, Katarina Tiklova \, ISS SciLifeLab10.15High-performance subcellular spatial profiling with Xenium In-Situ\, Johanna Stergiadou\, 10x genomics11.15Xenium data showcase\, Katarina Tiklova \, ISS\, SciLifeLab11.30Q&A and concluding remarks12.00Lunch & Mingle\n\n\n\nRegistration URL:https://www.scilifelab.se/event/start-discovering-with-xenium/ LOCATION:Ragnar Granit\, Biomedicum\, Solnavägen 9\, Solna\, 17165 CATEGORIES:Event ORGANIZER;CN="In Situ Sequencing Unit Scilifelab":MAILTO:iss@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230512T090000 DTEND;TZID=Europe/Stockholm:20230512T093000 DTSTAMP:20260407T141421 CREATED:20230201T125652Z LAST-MODIFIED:20230228T152444Z UID:10000800-1683882000-1683883800@www.scilifelab.se SUMMARY:[Clinical Talks] When ends meet\, molecular tools for clinical good DESCRIPTION:Ulf Landegren\n\n\n\nUppsala University \n\n\n\n\n\n\n\nUlf Landegren received his MD and PhD in Uppsala\, Sweden\, before spending five years at California Institute of Technology. As professor of molecular medicine in Uppsala his research focuses on developing molecular tools to meet needs in basic research and medicine\, from analyses of genetic variation with techniques such as oligonucleotide ligation assays and padlock probes to protein assays using oligonucleotide-conjugated antibodies in proximity assays for measuring protein expression levels in liquid samples or imaging their distribution in situ. Professor Landegren is a member of EMBO\, the Royal Swedish Academy of Sciences and the Royal Society of Sciences at Uppsala. He is member of several academic or industrial boards and advisory boards. He has authored 230 peer-reviewed publications\, and he is inventor of some 50 patents or applications. Work in his lab has so far given rise to 12 spin-out companies with a combined staff of more than 900 people\, including two companies that are publicly traded (Olink Proteomics and Q-linea). Technologies from his lab have also been licensed to many leading international biotech and diagnostic companies. \n\n\n\n \n\n\n\nregister to receive zoom link\n\n\n\nModerator: Michael Akhras \n\n\n\n\n\n\n\n \n\n\n\nClinical Talks\n\n\n\nClinical Talks is back for more! With a brand new and shiny Season 6. After successfully completing 5 seasons with > 70 enthusiastic Clinical Talkers to our record\, we have barely scratched the surface of all the amazing work our clinical\, academic and industry Life Science community has to offer. More about the upcoming events is available here. \n\n\n\nThese events are co-organized by Karolinska Institutet Innovations AB and SciLifeLab\, together with Colibri Ventures. URL:https://www.scilifelab.se/event/clinical-talks-when-ends-meet-molecular-tools-for-clinical-good/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/08/Square-500x500-Clinical-Talks@4x.png ORGANIZER;CN="Clinical Talks":MAILTO:precisionmedicine@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230515T080000 DTEND;TZID=Europe/Stockholm:20230516T170000 DTSTAMP:20260407T141421 CREATED:20220926T143527Z LAST-MODIFIED:20230514T190911Z UID:10000691-1684137600-1684256400@www.scilifelab.se SUMMARY:EMBL-SciLifeLab Data Science workshop DESCRIPTION:We would like to cordially invite members of the SciLifeLab and EMBL Communities to this workshop! This event will bring together researchers\, scientific and technical staff at the EMBL and SciLifeLab\, to make new acquaintances and collaborations and to learn and be inspired by each other. \n\n\n\nThe workshop program starts at 09:00 on May 15 and ends after lunch on May 16. \n\n\n\nThe workshop will be a hybrid event enabling participation to the wider community at all EMBL and SciLifeLab sites. \n\n\n\nLooking forward to meeting you in Uppsala in May! \n\n\n\nSessions\n\n\n\n\nInternal and external training and support\n\n\n\nProvision of public data services – computational tools\n\n\n\nArtificial intelligence\n\n\n\nIntegrated data management and Scientific workflow sharing\n\n\n\nTechnical infrastructure – computational solutions\n\n\n\nBiological theme – Imaging\n\n\n\nBiological theme – Human data\n\n\n\n\nParticipation by invitation only. Target audience: SciLifeLab and EMBL staff. \n\n\n\nScientific committee\n\n\n\n\nJohan Rung\, SciLifeLab\n\n\n\nCarolina Wählby\, SciLifeLab\n\n\n\nJan Korbel\, EMBL\n\n\n\nRupert Lueck\, EMBL\n\n\n\nRolf Apweiler\, EMBL\n\n\n\n\n\n\n\n\n\n\n\n\nProgram\n\n\n\nMonday May 15\nTime slotMonday\, May 1509:00Welcome and introductionOlli Kallioniemi\, SciLifeLab and DDLS Director\, and Jan Korbel\, Head of Data Science\, EMBL09:15Session 1: Internal and external training and supportThemes: what is training at EMBL\, Data Science training work stream -SciLifeLab training hub -Areas for synergiesModerator: Cath Brooksbank\, Head of Training\, EMBL-EBIEMBL Data Science Training: the story so farLisanna Paladin\, Bioinformatics Community Project Manager\, EMBLSciLifeLab Training Hub: the story starts now – what are the goals?Nina Norgren\, Training manager\, SciLifeLabPanel discussion and questions on stimulating exchange and collaboration10:20Coffee breakMounting of posters10:50Session 2: Provision of public data services – computational toolsModerator: Johanna McEntyre\, Associate Director for Service\, EMBL-EBISuccessfully managing a portfolio of data servicesJohanna McEntyre\, Associate Director for Service\, EMBL-EBIIntroductions to:Metabolic atlas Mihail Anton\, NBIS expert\, SciLifeLabProtein DatabaseSameer Velankar (PDB Europe)\, Team Leader\, EMBL-EBIPanel discussion: the future challenges and opportunities for public data servicesMihail Anton (Metabolic Atlas)Matthew Hartley (BioImage Archive)Cecilia Lindskog (Human Protein Atlas)Fergal Martin (Ensembl)Sameer Velankar (PDB Europe)11:55LunchPoster session13:15Session 3: Artificial IntelligenceModerator: Carolina Wählby\, Scientific Director of BioImage Informatics and Group Leader\, SciLifeLabAI in Image AnalysisAnna Kreshuk\, Group Leader\, EMBLAI in Cancer genomics\, prediction of treatmentIsidro Cortes-Ciriano\, Group Leader\, EMBL-EBIAI in spatial omicsCarolina Wählby\, Scientific Director of BioImage Informatics and Group Leader\, SciLifeLabServing AI modelsOla Spjuth\, Group Leader and AI coordinator\, SciLifeLabDiscussion on how to foster AI further14:20Coffee breakPoster session14:50Session 4: Integrated data management and scientific workflow sharingModerator: Henning Hermjakob\, Head of Molecular Systems\, EMBL-EBIExpression AtlasIrene Papatheodorou\, Team Leader – Gene Expression\, EMBL-EBIComplex WorkflowsMats Nilsson\, Platform Director Spatial Biology and Group Leader\, SciLifeLabDiscussion15:55Short break16:00Session 5: Technical infrastructure – computational solutionsModerator: Johan Rung\, Head of Data Centre\, SciLifeLabCloud – Beyond the hypeAndy Cafferkey\, Head of Technical Services\, EMBL-EBIThe IT role in empowering advanced research data managementRupert Lück\, Head of IT Services\, EMBLThe great datawanderung – how sensitive data is reshaping research infrastructures. Data transfer\, Compute moving to dataJohan Viklund\, NBIS Chief Technical Officer\, SciLifeLabNeeds and requirements to provide next generation of compute services (notebooks\, containerization\, GPUs\, etc) – energy\, carbon issuesOla Spjuth\, Group Leader and AI coordinator\, SciLifeLab17:05Wrap-up17:10Poster session with refreshments18:30Conference Dinner\n\n\n\n\nTuesday May 16\nTime slotTuesday\, May 1609:00Session 6: Biological theme – imagingModerator: Anna Klemm\, Head of the BioImage Informatics Facility\, SciLifeLabImage Data and Image analysisHjalmar Brismar\, Platform Scientific Director Advanced Light Microscopy unit and Group Leader\, SciLifeLabChristian Tischer\, Centre for Bioimage Analysis\, Scientist/IT Engineer\, EMBLPanel discussion: Workflows from image data generation to data analysis and finally image data publication. How are projects and data managed?Hjalmar Brismar\, SciLifeLabMatthew Hartley\, BioImage Archive Team Leader\, EMBL-EBIAnna Klemm\, SciLifeLabErik Lindahl\, Group Leader\, SciLifeLabChristian Tischer\, EMBL10:05Coffee breakPoster session10:35Session 7: Biological theme – human dataModerator: Helen Parkinson\, Team Leader SPOT\, EMBL-EBIIntegrated FEGA/FDA-components/Federated AnalysisOliver Stegle\, Associate Group Leader\, EMBLDevelopments from Human Data ServicesBengt Persson\, Platform Director NBIS\, SciLifeLabDiscussion11:40Workshop wrap-upCarolina Wählby\, Scientific Director of BioImage Informatics\, SciLifeLab and Rolf Apweiler\, Joint Director of EMBL-EBI12:00LunchAfternoon:Self-organized break-out tech workshops\, Site visits\, etc\n\n\n\n\n\n\n\n\n\n\n\n\nSessions\n\n\n\n \n\n\n\nSession 1: Internal and external training and support\nEMBL and SciLifeLab recently launched data science training initiatives. In this session we will share our approaches to developing data science training  – our plans\, our successes and our greatest challenges. An open discussion will explore areas for future collaboration and how we might work together to recognise those who dedicate their time\, usually on a volunteer basis\, to advanced scientific training. \n\n\n\n\nSession 2: Provision of public data services / computational tools of the SciLifeLab/EMBL-EBI \nExplore how to manage a portfolio of public computational tools and data services\, with real-world examples from both emerging and established resources\, and a panel discussion on the future challenges and opportunities for public data services \n\n\n\nIn this workshop: \n\n\n\n\nA keynote talk introduces key points of successfully managing a portfolio of data services\n\n\n\nOne emerging and one established data service summarize their management approach\n\n\n\nA panel discussion including other data service leads from EMBL-EBI and SciLifeLab discuss the future challenges and opportunities for public data services\n\n\n\n\n\nSession 3: Artificial intelligence\nIn this session we will focus on how to foster AI further (within EMBL-EBI and SciLifeLab) – What are the lessons learned during the last decade of incorporating learning-based methods using neural networks in biomedical research? Where lies the power\, and what are the limitations? How do we handle bottle-necks such as lack of reliably annotated training data\, and how do we avoid biases introduced by factors such as sample preparation and data collection? How can we include ‘the human in the loop’\, and how can we share models? \n\n\n\n\nSession 4: Integrated data management & Scientific workflow sharing\nModern\, data-intensive science requires complex and ideally reproducible workflows. Based on two opening presentations\, one from a complex “research” workflow background\, one from a repeatable “service” background\, and a subsequent panel discussion\, we want to explore \n\n\n\n\nWhat are the scientific demands and requirements for computational workflows?\n\n\n\nHow to strike the right balance between reproducibility and flexibility?\n\n\n\nWhat is the current status and future aspirations for technical support of computational workflows?\n\n\n\nWhat are the opportunities for coordination / integration of internal /external workflows between SciLifeLab and EMBL?\n\n\n\n\n\nSession 5: Technical infrastructure – computational solutions\nThe technical infrastructures and computational solutions provided by teams across EMBL and SciLifeLab are at the heart and the critical foundation of data science activities in both institutions. In this session\, we aim to initiate a cross-organizational dialogue and to set the stage for further networking among interested stakeholders to explore key IT and technical challenges and learn more about potential solutions being explored on both sides. \n\n\n\nThe session will start with four short presentations to stimulate the open discussion that will follow. Our input from the presentations will cover a wide range of technical topics and challenges: \n\n\n\ni) key aspects of using cloud services\, \n\n\n\nii) opportunities to improve scientific data management via dedicated IT solutions\, \n\n\n\niii) the challenges associated with shared analysis and transfer of (sensitive) data across centres\, and \n\n\n\niv) exploring the needs for next-gen computational\, data analytics\, and management services for data science in the life sciences. \n\n\n\n\nSession 6: Biological theme – imaging\nIn the imaging session we will discuss workflows from image data generation to data analysis and finally publication. Which paths does microscopy data take at EMBL and SciLifeLab? How can data analysis and data management be integrated early on in the project discussions? The session will also give an insight to which kind of imaging projects are handled at both EMBL and SciLifeLab\, since imaging data can have a broad range of characteristics and comes with different analysis and data management needs. \n\n\n\n\nSession 7: Biological theme – human data\nThe Human Data session will focus on challenges working with federated and multidimensional human data\, interfacing with national data \, e.g. Genomics Data Infrastructure (GDI; Persson) enabling realisation of the European 1+ Million Genome project\, and the experience of working at the interface of clinical research with industrial partners\, including the Mannheim alliance (Stegle) and precompetitive industrial collaborations\, e.g.OpenTargets (https://www.opentargets.org/). The session will have two presentations (Stegle\, Persson) followed by a panel discussion. It aims to define the skills set\, mindset\, technical solutions to address shared problems of human research data.  URL:https://www.scilifelab.se/event/embl-scilifelab-data-science-workshop/ LOCATION:Eva von Bahr\, Ångström Laboratory\, Uppsala University\, Uppsala\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230522T151500 DTEND;TZID=Europe/Stockholm:20230522T161500 DTSTAMP:20260407T141421 CREATED:20230502T162232Z LAST-MODIFIED:20230503T062420Z UID:10000874-1684768500-1684772100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Photo-“click” and photo-“unclick” strategies for spatiotemporal control of substrate immobilization and release DESCRIPTION:Vladimir Popik \, Professor of Chemistry \n\n\n\nUniversity of Georgia\, USA \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nVladimir Popik received his MSc degree (Chemistry) from the Leningrad State University (1986\, Leningrad\, USSR). His PhD project “Conformational Structure and Photochemical Reactivity of 1\,3-Diazodicarbonyl Compounds” was under the supervision of Prof. Irina Korobitcina and Valery Nikolaev at St. Petersburg State University (same school\, new name). After defending his PhD dissertation in 1990\, he continued as a Research Scientist. In 1992 joined Prof. A. Jerry Kresge group at the University of Toronto as a postdoc then accepted Visiting Research Professor position at the University of Toronto in 1996. In 1999 Valdimir joined the faculty of the Center for Photochemical Sciences at the Bowling Green State University as an Assistant Professor. In 2005 he was promoted to Associate Professor. In 2006 Vladimir Popik moved to the University of Georgia where he is now Professor of Chemistry. \n\n\n\nAwards: NSF Career Award 2004; Georgia Cancer Coalition Distinguished Scholar 2006; Senior Member of the National Academy of Inventors 2022.Research interests: devlopment of photochemical tools for biochemical\, bioimaging\, and material sciences applications; practical use of two-photon photochemistry; development of novel strategies for click and photoclick ligations; rational design and synthesis light-activated antimitotic agents and gasotransmitteres; investigation of the mechanism of fast reactions.120 Peer-reviewed publications\, (h-index = 41) \, 10 patents. \n\n\n\n \n\n\n\nPhoto-“click” and photo-“unclick” strategies for spatiotemporal control of substrate immobilization and release\n\n\n\nPhotochemical triggering of “click” reactions permits the spatial and temporal control of the derivatization\, labelling\, cross-linking and patterning of various substrates. The absence of potentially detrimental catalysts and/or activating reagents is another beneficial feature of this approach. “Photo-SPAAC” click strategy is based on the photo-decarbonylation of cyclopropenone moiety incorporated into an 8-membered ring. Induction of photo-“click” ligation using two-photon excitation with NIR light (700 – 800 nm or ~ 1100 nm) allows for the 3-dimensional control of the process.Photo-cleavable linkers\, on the other hand\, allow for the spatiotemporal control of the substrate release. \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nHost: Daniel Fürth\, UU furth@scilifelab.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-photo-click-and-photo-unclick-strategies/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230525T080000 DTEND;TZID=Europe/Stockholm:20230526T170000 DTSTAMP:20260407T141421 CREATED:20221212T160045Z LAST-MODIFIED:20230524T062900Z UID:10000750-1685001600-1685120400@www.scilifelab.se SUMMARY:CRISPR as a research tool in cancer and regenerative medicine DESCRIPTION:International Symposium \n\n\n\nThis two-day event will bring together leading international experts in the field of CRISPR technology and CRISPR applications in basic research in cancer and regenerative medicine. Attendees will have the opportunity to gain a deeper understanding of the potential and limitations of CRISPR as a research tool\, both in precision genome engineering and in massively parallel\, functional genomics applications and unbiased screens. \n\n\n\nThere will be a poster session\, and short talks will be chosen from submitted abstracts. This event will provide a valuable opportunity for students\, researchers\, educators\, and industry professionals to learn about the latest developments and applications of this exciting and rapidly advancing field. PhD students are encouraged to submit a poster abstract to obtain educational credits towards their PhD. Come join us and learn how CRISPR can accelerate YOUR research! \n\n\n\nThe registration fee of 1\,000 SEK (excl. VAT) includes access to the conference\, lunches and coffee on 25-26 May 2023\, as well as snacks and drinks at the poster session on May 25. According to Swedish and EU legislation 25% VAT will be added to the registration fee before payment.  \n\n\n\n \n\n\n\nAbstracts\n\n\n\nCRISPR Symposium 2023 AbstractsDownload\n\n\n\nProgram\n\n\n\nFinal-Programme-1Download\n\n\n\n\n\n\n\nConfirmed Speakers\n\n\n\nExpanding the CRISPR screening toolbox with Cas12a\, base editors\, and moreJohn Doench\, Broad MITBetter genome editing by listening to the cellsJacob Corn\, ETH ZurichFine-tuning of transcription factor expression dosage uncovers non-linear effects in regulatory networksTuuli Lappalainen\, KTH and New York Genome CenterUncovering key resistance mechanisms to cancer immunotherapyYumeng Mao\, Uppsala UniversityHarnessing the CRISPR toolbox to engineer biologyRandall J. Platt\, ETH ZurichTarget discovery – arrayed & pooled CRISPR screening to drive drug discoveryDouglas Ross-Thriepland\, AstraZeneca & CRUK Functional Genomics CentreNew frontiers in pooled CRISPR screensNeville Sanjana\, New York Genome CenterCRISPR discovery platforms for human T cell therapiesEric Shifrut\, Tel Aviv University\n\n\n\n \n\n\n\nOrganizers\n\n\n\nBernhard Schmierer\, CRISPR Functional Genomics/Karolinska InstitutetFredrik Wermeling\, Karolinska Institutet (Wermeling lab website) \n\n\n\nSponsors\n\n\n\n\nCancerfonden\n\n\n\nSciLifeLab \n\n\n\nPhenoTarget\n\n\n\nIDT\n\n\n\nSynthego\n\n\n\nCountagen\n\n\n\nBioNordika\n\n\n\nSingleron BioTechnologies \n\n\n\n\n \n\n\n\nContact\n\n\n\nCrispr2023@akademikonferens.se URL:https://www.scilifelab.se/event/crispr-as-a-research-tool-scilifelab-international-symposium/ LOCATION:Andreas Vesalius Lecture Hall\, Karolinska Institutet\, Berzelius väg 3\, Solna\, 171 65\, Sweden CATEGORIES:Event ORGANIZER;CN="CRISPR Functional Genomics":MAILTO:bernhard.schmierer@ki.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230526T091500 DTEND;TZID=Europe/Stockholm:20230526T120000 DTSTAMP:20260407T141421 CREATED:20230227T134503Z LAST-MODIFIED:20230227T135039Z UID:10000813-1685092500-1685102400@www.scilifelab.se SUMMARY:Advanced fluorescence microscopy symposium – super resolution MINFLUX applications DESCRIPTION:The Advanced Light Microscopy facility welcomes you to a symposium on super resolution MINFLUX \n\n\n\nfluorescence microscopy applications. \n\n\n\nProgram\n\n\n\n09:15MINFLUX imaging & trackingSebastian Schnorrenberg – EMBL09:55DNA-PAINT MINFLUXDaniel Jans –  University Medical Center GöttingenCoffee break11:00Tracking MINFLUXElias Amselem – Uppsala University\n\n\n\nSubmit your registration to: \n\n\n\nhans.blom@scilifelab.se URL:https://www.scilifelab.se/event/advanced-fluorescence-microscopy-symposium-super-resolution-minflux-applications/ LOCATION:Samuelssonsalen\, Tomtebodavägen 6\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/02/Place-holder-image.png ORGANIZER;CN="Advanced Light Microscopy Unit":MAILTO:stewen@kth.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230526T110000 DTEND;TZID=Europe/Stockholm:20230526T120000 DTSTAMP:20260407T141421 CREATED:20230414T123346Z LAST-MODIFIED:20230522T120452Z UID:10000861-1685098800-1685102400@www.scilifelab.se SUMMARY:SciLifeLab Data Platform Launch DESCRIPTION:Join SciLifeLab Data Centre for the official launch of the SciLifeLab Data Platform. At this launch event\, we will demonstrate how the data platform supports DDLS\, the services we offer\, and how you can get access to hosting resources. In addition\, a number of our users will present their user cases\, followed by a summary. \n\n\n\nDate: May 26th at 11-12 CEST \n\n\n\nThe SciLifeLab Data Platform is a technical environment offering data-centric tools and databases as well as an overarching website with the goal to support and accelerate data-driven life science research in Sweden. \n\n\n\nThe services hosted on the Platform are available to all life science researchers in Sweden. The platform is maintained by the SciLifeLab Data Centre.The services hosted on the SciLifeLab Data Platform adhere to the values of open science\, transparent research\, and FAIR as well as good data management practises throughout the data life cycle. \n\n\n\nRegister to join the event\n\n\n\nLaunch event \n\n\n\n11.00-11.15 Welcome and introduction to the SciLifeLab Data Platform\, Johan Rung\, Head of SciLifeLab Data Centre \n\n\n\n11.15-11.35 Platform services\, and how to access to hosting resources\, Liane Hughes\, SciLifeLab Data Centre \n\n\n\n11.35-11.50 Flash talks by Platform users Elin Kronander\, NBIS\, Wesley Schaal\, Uppsala University/ SciLifeLab\, and Oliver Billker\, Umeå University/ SciLifeLab) \n\n\n\n11.50-12.00 Summary \n\n\n\n \n\n\n\nWelcome \n\n\n\nRegistration open till Friday May 26 12.00 CEST \n\n\n\nThis event will be recorded and available on data.scilifelab.se \n\n\n\nFor more information please contact SciLifeLab Data Centre at datacentre@scilifelab.se URL:https://www.scilifelab.se/event/scilifelab-data-platform-launch/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/04/SciLifeLab-Data-Platform-Launch-event.png ORGANIZER;CN="SciLifeLab Data Centre":MAILTO:datacentre@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230529T090000 DTEND;TZID=Europe/Stockholm:20230529T120000 DTSTAMP:20260407T141421 CREATED:20230418T142805Z LAST-MODIFIED:20230524T130852Z UID:10000862-1685350800-1685361600@www.scilifelab.se SUMMARY:PacBio Revio Launch Event DESCRIPTION:The National Genomics Infrastructure (NGI) are happy to announce the acquisition of the latest PacBio sequencing system – the Revio. One Revio SMRT sequencing cell can produce approx. 90Gbp of data corresponding to 30x of a human genome in 24hrs. The instrument generates highly accurate HiFi reads plus methylation calling for half the cost compared to previous systems.  \n\n\n\nFor those of you that have the possibility\, NGI invites you to a half-day seminar on May 29th to learn more about the new Revio system! The event is scheduled between 9-12 in Navet\, BMC\, Uppsala\, and lunch will be served to registered participants. \n\n\n\nDuring the seminar\, there will also be an NGI-sponsored lottery with the possibility to win free Revio sequencing!  \n\n\n\nSusanne Hellstedt Kerje on behalf of NGI \n\n\n\n\n\n\n\nRegistration\n\n\n\n\n\n\n\nProgram\n\n\n\nBMC\, Navet\, Entrance C11\, Husargatan 3\, Uppsala09:00Welcome (Susanne Hellstedt Kerje\, NGI-Uppsala)09:10Reveal more with HiFi sequencing at scale – Introduction to PacBio Revio System (Somar Al-Walai\, PacBio)09:30NGIs experience from the Revio system (Adam Ameur\, Susanne Hellstedt Kerje\, NGI-Uppsala)10:00Coffee10:30Complex genomic rearrangements: an underestimated cause of rare dieseases  (Anna Lindstrand\, Karolinska Institutet)11:00Disentangling genome evolution and speciation in polyploid grasses (Pär Ingvarsson\, Swedish University of Agricultural Sciences)11:30Changing the game with PacBio highly accurate long-read sequencing (Nick Jordan\, PacBio)11:50Q&A session including announcement of winner in the Revio sequencing lottery12:00Lunch to registered participants URL:https://www.scilifelab.se/event/pacbio-revio-launch-event/ LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/webp:https://www.scilifelab.se/wp-content/uploads/2023/04/img-sharing-revio.webp ORGANIZER;CN="NGI Uppsala":MAILTO:susanne.kerje@igp.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230530T120000 DTEND;TZID=Europe/Stockholm:20230530T130000 DTSTAMP:20260407T141421 CREATED:20230522T143133Z LAST-MODIFIED:20230522T143352Z UID:10000896-1685448000-1685451600@www.scilifelab.se SUMMARY:Cross-linking and Hydrogen-Deuterium Exchange Mass Spectrometry DESCRIPTION:In the frame of the “SciLifeLab Site Umeå / KBC Infrastructure Seminar Series”\, the seminars will be organised every second Tuesday during spring 2023. The seminars will be held in a hybrid format IRL in Glasburen\, KBC\, and online via Zoom. Learn more about the seminar series and Schedule for Spring 2023 here. \n\n\n\nOn May 30th\, 12:00-13:00\, SciLifeLab Site Umeå / KBC Infrastructure Seminar Series presents: \n\n\n\nCross-linking and Hydrogen-Deuterium Exchange Mass Spectrometry as a National Infrastructure Service \n\n\n\nSimon Ekström\, Swedish National Infrastructure for Biological Mass Spectrometry (BioMS)\, Lund University\, Lund\, Sweden and Structural Proteomics\, SciLifeLab Integrated Structural Biology platform (ISB)\, Lund\, Sweden \n\n\n\nSign up (latest by Monday\, 29 May\, 10 a.m.) for on-site attendance to reserve your free lunch sandwich: \n\n\n\nRead more\n\n\n\nor follow online via Zoom: https://umu.zoom.us/j/63138997026 (registration is not required). URL:https://www.scilifelab.se/event/cross-linking-and-hydrogen-deuterium-exchange-mass-spectrometry/ LOCATION:Glasburen Seminar Room\, Chemical Biological Centre (KBC) Building\, Umeå University\, Umeå\, 901 87\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230531T140000 DTEND;TZID=Europe/Stockholm:20230531T150000 DTSTAMP:20260407T141421 CREATED:20230523T123528Z LAST-MODIFIED:20230523T131015Z UID:10000894-1685541600-1685545200@www.scilifelab.se SUMMARY:Well-being and mental health skills are human rights & of monumental importance to scientific excellence DESCRIPTION:We are excited to host our first Coaching in Science Initiative (CSI) Seminar \n\n\n\nOn-site location: Gamma 2 lunch room \n\n\n\nThis will be an introduction to CSI\, how coaching as a tool can improve our mental health\, and how it connects with scientific excellence.  \n\n\n\nWe will begin with a 15-20 min talk\, held in Solna and over zoom. Then proceed with a reflection and discussion held only on-site. We encourage other sites to meet together and participate by listening in on the talk and then hold their own discussion afterwards. Hopefully seeding many local chapters of CSI. \n\n\n\nTo help facilitate discussion and reflection\, consider the follow starter questions: \n\n\n\nAwareness: where does coaching happen in our lives already?Analysis: what would the ideal coaching situation look like for us?Alternative: how can we adapt current practices to include coaching?Action: what is our plan going forward regarding coaching at work/in life? \n\n\n\n  \n\n\n\nLink to Zoom URL:https://www.scilifelab.se/event/well-being-and-mental-health-skills-are-human-rights-of-monumental-importance-to-scientific-excellence/ LOCATION:Hybrid event in Gamma 2 lunchroom and zoom\, Tomtebodavägen 23 B\, Solna\, 17165\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/05/CSI_logo_text_mail.png ORGANIZER;CN="Coaching in Science Initiative (CSI)":MAILTO:sami.saarenpaa@scilifelab.se END:VEVENT END:VCALENDAR