Policing secretion: cargo capture into ER-derived vesicles initiates secretion
2025-02-21 10:00 - 11:00 (Europe/Stockholm) | Gamma 7 Lunchroom, Tomtebodavägen 23A, Solna, 17121
Visiting Professor Liz Miller from the Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Scotland UK, will give a seminar at SciLifeLab Campus Solna. The seminar should be of particular interest to cell and structural biologists interested in membrane associated processes operating during the early stages of the secretory pathway.

Background

One third of the proteins encoded in eukaryotic genomes pass through the secretory pathway, entering via the endoplasmic reticulum (ER). The Miller lab has made pivotal contributions, dissecting the molecular mechanisms operating during the early stages of ER-associated secretory protein biogenesis. Specifically, the research has focused on understanding protein quality control and export from the ER. The lab has exploited the budding yeast, Saccharomyces cerevisiae, as a model system, taking advantage of the full spectrum of biochemical, genetic, genomic and proteomic tools, including cryo-EM. The research has defined mechanisms relevant to a number of human diseases, most notably cystic fibrosis and similar diseases of protein misfolding. Recently, the Miller lab has been examining how secretory cargo is selected for ER export in human cells, which will be the focus of her talk here at SciLifeLab Campus Solna.

Biography

Professor Liz Miller carried out her PhD in Melbourne, Australia, working on intracellular traffic of plant defence proteins. In 1999, as a Jane Coffin Childs Postdoctoral Fellow, she joined Randy Schekman’s lab (note: prior to his Nobel Prize awarded in 2013) at the University of California, Berkeley. In the Schekman lab, Liz established the mechanistic basis for capture of nascent secretory proteins into ER-derived COPII vesicles. In 2005 Liz established her independent lab at Columbia University in New York, and after 10 years moved to become a Programme Leader/MRC Investigator at the MRC Laboratory of Molecular Biology in Cambridge, where she maintains a small lab. In 2023, Liz joined the Division of Molecular, Cell and Developmental Biology within the School of Life Sciences in 2023.

Read more
https://www.dundee.ac.uk/people/liz-miller

https://www2.mrc-lmb.cam.ac.uk/group-leaders/h-to-m/liz-miller/

Host: Per Ljungdahl, per.ljungdahl@scilifelab.se

PULSE Challenge: ML/AI approaches for designing proximity-inducing small molecules – PROTAC cell permeability and bioavailability
2025-02-25 12:00 - 13:00 | Online event via Zoom
The seminar series PULSE Challenge is connected to the MSCA co-funded* postdoctoral program SciLifeLab PULSE, that will train 48 future leaders in life sciences. The program focuses on innovative, fundamental and translational research carried out in supportive and diverse academic and industrial environments, preparing postdocs with necessary skills for long-term career sustainability. Click HERE to find out more about SciLifeLab PULSE

On-line event via Zoom

Register Here

Presenters: Prof. Jan Kihlberg & Assoc. prof. Vasanthanathan PoongavanamUppsala University, Sweden

Abstract:Most PROTACs which have a “druglike” oral bioavailability (>5%) are based on a CRBN E3-ligase ligand, but a few VHL PROTACs also display >5% bioavailability. Use of 2D descriptors places oral drugs, CRBN and VHL PROTACs in different parts of chemical space, while the use of 3D descriptors indicates that the chemical spaces overlap. Use of 3D descriptors may therefore enhance the probability of discovering PROTACs with satisfactory oral bioavailability

We have studied CRBN and VHL PROTACs by NMR spectroscopy and MD simulations. These studies revealed that the propensity of the PROTACs to adopt folded and semi-folded conformations with low solvent – accessible 3D polar surface area correlated to higher cell permeability. The length, chemical nature and flexibility of the linker was found to be essential for allowing intramolecular hydrogen bonds, π–π interactions and van der Waals interactions to stabilize (semi)folded conformations for permeable PROTACs in a membrane-like environment.

Use of MD simulations for prediction of the conformations and properties of PROTACs is time consuming. However, classification models that were developed by machine learning using 2D descriptors allowed differentiation between VHL PROTACs that had high or low cell permeability. Such models can be integrated as effective filters to prioritize PROTACs for synthesis in the design process. Nevertheless, certain challenges remain, including the imbalanced nature of datasets, and model interpretability. Addressing these limitations in future studies will be crucial for maximizing the full potential of machine learning in PROTAC design.

Biographies:Jan Kihlberg holds a chair in Organic Chemistry at Uppsala University, Sweden since 2013. His key research interests are to understand what properties convey cell permeability, aqueous solubility and target binding to drugs such as PROTACs and macrocycles in the beyond rule of 5 space and to translate this knowledge into guidelines for design. He has published more than 200 peer–reviewed publications and book chapters. He establishing his independent research group at Lund University in 1991, became full professor in Bioorganic Chemistry at Umeå University in 1996, then moved to AstraZeneca R&D in Gothenburg in 2003 while maintaining a research group at Umeå University. At AstraZeneca Prof. Kihlberg held the role as Director, Head of Medicinal Chemistry for seven years.

Vasanthanathan Poongavanam is a computational chemistry and AI expert at the DDD Platform, SciLifeLab, Uppsala University, Sweden. His research focuses on applying computational chemistry and AI methodologies to accelerate drug discovery projects. He has authored more than 60 scientific publications, including research articles, reviews, and book chapters.

SciLifeLab Lund Seminar Series | DST
2025-02-26 15:00 - 16:00 | Belfragesalen, BMC D15, Klinikgatan 32, Lund, Sweden
Welcome to the SciLifeLab Lund seminar series!

These seminars are designed to highlight SciLifeLab Lund, our cutting-edge research infrastructure, and the diverse resources available to the scientific community.

In the 5th seminar, we will have a look into the Display & Selection Technologies unit (DST) which is part of the SciLifeLab Drug Discovery & Development platform. The DST unit supports the development of therapeutic antibodies and single domain antibodies.

Mikael Mattsson (DST’s Head of Unit) will present the unit, and Carl Sandén (Division of Clinical Genetics at Lund University) will will showcase a project carried out in collaboration with the facility.

Please note that the seminars are site only but the recordings are available HERE.

Registration

Register for the next seminars!

26th March 2025 | Lund University Bioimaging Centre (LBIC)

Register Seminar March

23rd April 2025 | Lund Protein Production Platform

Register Seminar April

28th May 2025 | National Bioinformatics Infrastructure (NBIS)

Register Seminar May

18th June | Structural Proteomics

Register Seminar June

CBGE & DDD Roadshow in Lund | From Decoding Biology to Drug Discovery
2025-03-05 11:00 - 15:00 | Belfragesalen, BMC D15, Klinikgatan 32, Lund, Sweden
SciLifeLab Lund is pleased to welcome SciLifeLab Chemical Biology & Genome Engineering Platform (CBGE) and Drug Discovery and Development Platform (DDD) and host their Roadshow in Lund.

During the seminar “Small Molecules, CRISPR & Chemical Proteomics: From Decoding Biology to Drug Discovery”, we will have a look into both platforms and an user will showcase a project carried out in collaboration with them. The Seminar will be followed by a light lunch and individual consultation meetings.

Register here!

In this seminar:

The SciLifeLab Chemical Biology & Genome Engineering Platform

Anna-Lena Gustavsson, Platform director, KI

Fredrik Ek, Chemical Biology Consortium Sweden, LU

Bernhard Schmierer, CRISPR Functional Genomics, KI

Massimiliano Gaetani Chemical Proteomics, KI

The SciLifeLab Drug Discovery and Development Platform

Per Arvidsson, Platform director, KI

User presentation

Functional chemical reprogramming of cancer cells to induce antitumor immunity. Fábio Fiúza Rosa. Co-founder and Head of Research, Asgard Therapeutics AB, prev. Filipe Pereira research group LU.

Automation of research processes with LLMs and AI
2025-03-06 10:00 - 16:00 | Eva & Georg Klein lecture hall, Biomedicum, Solnavägen 9, 171 65 Solna, Solna, 171 65, Sweden
SciLifeLab is thrilled to invite you to the symposium ‘Automation of research processes with LLMs and AI’, to be held on March 6 at Eva & Georg Klein lecture hall, Biomedicum, Karolinska Institutet Campus Solna.

The purpose of the symposium is practical knowledge sharing, inspiration, and reflection on the future of scientific processes in life sciences and health research. Academic, healthcare, and industry researchers working within the broad life sciences are welcome to attend.

More and more AI-based tools are currently being integrated in scientific research processes, from simple academic text editing tools to automated labs empowered by large language models (LLMs) running experiments and making scientific conclusions. For researchers in life sciences and health, developments in the AI technologies are important because of the high potential, large monetary investments, but also expectations about future breakthroughs.This one-day event offers an opportunity for the researchers to hear about specific examples of incorporating Large Language Models (LLMs) and other recent developments in foundational AI models in research workflows as well as to discuss the future of scientific research processes with this new technology present.

We will start the morning with inspirational talks about new advances in research workflow automation. During lunch, there will be a possibility to network and discuss different perspectives with other attendees. After lunch we plan to have interactive sessions where the audience will have an opportunity to share and discuss visions and expectations, including spontaneous flash/pop-up talks by the attendees.

The talks will be livestreamed through Zoom. The rest of the event is on-site in Biomedicum only.

Registration

Registration

Participation is free of charge on the first-come first-served basis. Refreshments and lunch will be served for the on-site participants. Unfortunately, we cannot accommodate allergies or dietary preferences for those who register after March 1. If you register to listen to livestreamed talks on Zoom, you will receive a link on the day of the event. The talks will not be recorded and saved, only streamed live on the day.

Register to attend

Waiting List

To avoid empty seats, registration will remain open until the event begins. If we reach full capacity, a waiting list will be activated. Sign up for the waiting list, and you will automatically receive an email when a spot becomes available. You must accept to secure the spot. If you decline, the offer will go to the next person on the waiting list.

Cancellation

To minimize empty seats and especially food waste, you must cancel your registration if you are unable to attend the event. If a waiting list is activated, your spot will go to someone else. Otherwise, your cancellation will result in us covering the cost of your refreshments and lunch.

If you have questions, please contact datacentre@scilifelab.se

Speakers

Olli Kallioniemi (KI/FIMM) – AI-Empowered Life Science: How Can You Benefit Today and in the Future?
Nobel prizes, huge tech investments, generative AI and AI agents, multidisciplinary expertise, expectations on emerging superhuman intelligence, and 1,000+ AI-powered approved medical devices all highlight AI’s transformative potential for life scientists. Yet, many researchers remain unaware or skeptical, often due to limited exposure. This talk will cover AI’s current and future impact in life sciences, highlighting how it can empower every scientist, boost research productivity, and foster innovative approaches.

Olli Kallioniemi is the Founding Director of the SciLifeLab & Wallenberg Data-Driven Life Science (DDLS) Program and served as Director of SciLifeLab from 2015 to 2024. He is a Professor of Molecular Precision Medicine at Karolinska Institute (OnkPat) and holds a joint appointment at the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki. He has recently focused on exploring and explaining the opportunities that AI offers for life science research and how AI can benefit every researcher.

Melissa Harrison (EMBL-EBI) – How Europe PMC uses and supports LLM development for research workflows
Europe PubMed Central (Europe PMC), developed by EMBL-EBI, is a free, open-access literature database containing over 45 million life science literature outputs; over 10 million of which are full text. This includes almost a million preprints from 34 different servers. Associated research outputs, such as data, are linked to the literature, which is also enriched with additional persistent identifiers, text mined funding information, and text mined annotations of the articles and supplementary files. Annotations are dictionary-based and are being transitioned to a machine learning approach. This talk will discuss the potential of this transition and will explore how Europe PMC plans to leverage machine learning in the future while maintaining the community’s trust in its curated, open dataset as a reliable resource for scientific research. Words of caution about AI and ghost workers, including biocurators, will also be mentioned.

Melissa Harrison is the Lead of Literature Services at EMBL’s European Bioinformatics Institute (EMBL-EBI). After completing a biology degree at King’s College London she worked in scientific publishing for two decades. In her previous role at eLife she honed her skills in open science policy and implementation and has been instrumental in the propagation of open persistent identifiers and metadata.

Aasa Feragen (DTU) – AI fairness — it doesn’t have to be hard
Aasa Feragen is a Professor in Medical Image Analysis at the Technical University of Denmark (DTU).

Martin Eklund (KI) – Limitations of foundation models for achieving optimal performance
Foundation models are undoubtedly highly useful. But are they a panacea for advancing performance of deep learning systems? If not, what are their limitations? In the presentation, we explore these questions using large and rich digitized prostate pathology data as an example.

Martin Eklund is professor of epidemiology at the Department of Medical Epidemiology and Biostatistics where he focusses his research on reducing the mortality of prostate cancer as well as the negative side effects of today’s imprecise diagnostics and treatment selection. He works a lot on development of AI systems for clinical decision making.

Prashant Singh (UU) – AI and Optimization for Science: Principles and Pitfalls
Data-driven science has emerged as a modern pillar of science, complementing theory, experiments and computational approaches. Scientific workflows – from design of experiments to data analysis, have greatly benefited from tools and techniques from various fields including optimization, statistics, computational science, etc. In this talk, we will motivate principled approaches for various stages of the scientific research pipeline, from traditional foundations such as optimization, to recent AI-based advances such as large-language models.

Prashant is an Assistant Professor, and a SciLifeLab fellow hosted at the Department of Information Technology, Science for Life Laboratory, Uppsala University. His research interests involve developing machine learning and optimization methods to enable fast, data-efficient analysis and processing of scientific data, particularly in the domain of life sciences.

Phil Ewels (Seqera) – Building and testing scientific workflows with LLMs and AI agents
Nextflow has become the leading tool for scientific workflows in bioinformatics, but writing workflows can be challenging. This talk introduces Seqera AI, a new tool that helps generate Nextflow pipelines either from scratch, from existing scripts, or even other workflow languages. I’ll discuss how Seqera AI is able to generate best-practice DSL2 code that follows nf-core guidelines, and how we go beyond just code generation: creating and running test suites with AI agents, streamlining development while improving code quality and validation.

Phil Ewels is Senior Product Manager for Open Source at Seqera, working with Nextflow, MultiQC, nf-core and Wave. Before joining Seqera in 2022, Phil worked at the National Genomics Infrastructure (NGI) at SciLifeLab in Stockholm, Sweden. It was through this work that Phil became involved with Nextflow and eventually co-founded the nf-core community. Phil’s career has spanned many disciplines from lab work and bioinformatics research in epigenetics, through to software development and community engagement. He is the author of MultiQC, SRA-Explorer, QCFail.com, and has a PhD in Molecular Biology from the University of Cambridge, UK.

Program

Automation_of_research_workflows_March_6_programmeDownload

Ultrasensitive variant detection with ddPCR and sRCA
2025-03-07 14:00 - 15:00 | Online event via Zoom
Clinical Genomics Webinar Series

Clinical Genomics Uppsala is hosting this webinar as part of the webinar series by the Clinical Genomics Platform

join zoom webinar

The webinar will focus on Rare tumor-specific mutations are valuable markers for tracking disease progression and therapy responses. As disease relapse remains a major challenge in Myelodysplastic Syndrome, the need for ultrasensitive assay techniques for detecting these very low frequency mutations are needed to detect relapse at the earliest time possible.

In Clinical Genomics Uppsala we explore superRCA assays—an advanced, highly sensitive, and cost-effective amplification technology, in a retrospective study in patients with MDS, monitoring the pre-identified patients mutations after hematopoietic stem-cell transplantation. This method has shown a very high sensitivity, enables detection of DNA variants at very low frequencies using standard flow cytometry, and the results and performance was compared with the results of ddPCR, commonly used method in the clinic.

Everyone is welcome so feel free to spread the details with anyone who may be interested. Hope to see you there!

Host: Malin Melin, co-PD

Invited speakers: Lei Chen, Rarity Bioscience and Sara Löfgren, Clinical Genomics Uppsala

[The Svedberg seminar] - Human beta cell protection by Nature
2025-03-10 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Bart RoepProfessorLeiden University Medical Center, Netherlands

Bio

Bart Roep is Professor of Medicine & Professor of Diabetology, Immunopathology and Intervention at the Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands, where he heads the Section Immuno-modulation & Regenerative Medicine. He studied Medicine and Life Sciences at the University of Amsterdam and obtained his PhD in Medicine at Leiden University. He pioneered studies on the role of T-cells in the pathogenesis of T1D and discovered some of their targets in β-cells, provided seminal proof of their role in human β-cell destruction and defined immune correlates of disease progression and therapeutic intervention. He contributed to a suite of clinical intervention trials in T1D, including pioneering strategies on tissue-specific tolerance induction, regenerative medicine, gene and stem cell therapy, faecal microbiome transplantation and β-cell replacement therapies (pancreatic donor islets and embryonic stem cell derived β-cell progenitors). A profound twist in prevalent belief of the immunopathogenesis involved his discovery of the role of β-cells in their own demise. His current focus is on regenerative medicine in T1D from an immunological perspective.

Human beta cell protection by Nature

Type 1 diabetes results from an autoimmune mediated destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans in people with genetic predisposition to develop this disease. Insulin gene (INS) variation and beta-cell stress associate with risk for development of type 1 diabetes (T1D) and autoimmunity against insulin. We discovered the relationship between ER stress and insulin mRNA from INS risk variants in human β-cells, and how this variation relates to β-cells function, stress and immunogenicity. This novel explanation for genetic protection from T1D inferred by INS polymorphism, puts β-cells in the center of T1D pathogenesis. Beta cells carrying this particular protective INSP variant can alleviate ER stress by insulin mRNA decay, resulting in reduced immunogenicity and improved islet function. We propose that INSP is a causal variant contributing to genetic protection from T1D. The clinical and therapeutic implications of this discovery will be discussed.

Host: Olov Andersson olov.andersson@mcb.uu.se, UU

Exhibition in Navet at BMC, Uppsala University
2025-03-11 09:00 - 2025-03-13 15:00 | Navet, SciLifeLab Uppsala, SciLifeLab Uppsala, BMC C11, Husargatan 3, Uppsala, 75237, Sweden
On March 11-13, between 09.00-15.00, you have a new opportunity to visit our exhibition in Navet at BMC. This is a chance to receive information and updates from 30 of the leading life science companies in Sweden. The entrance to Navet will be open between 09:00-15:00 for external visitors.

The Nagoya Protocol in Action: Practical Steps for Compliance and Benefit-Sharing
2025-03-11 10:00 - 11:00 | Online event via Zoom
This presentation will focus on how to handle the Nagoya Protocol in practice. Whether you’re new to it or already have some experience, you’ll get clear guidance on how to stay compliant, draft agreements, and navigate access and benefit-sharing rules. We’ll go through practical steps, common challenges, and what to aim for when working with genetic resources. The goal is to make the process more manageable and help you confidently meet legal requirements while building fair collaborations.

Conducting research using genetic resources? Collecting biological material?The Nagoya Protocol establishes a framework that helps researchers access genetic resources for research & development in return for a fair share of any benefits from their use. Curious about the rules for the use of genetic resources? In this seminar, Sebastian Bromander from SLU – Sveriges Lantbruksuniversitet will explain how to handle the Nagoya Protocol in practice!

Presenter: Sebastian BromanderSwedish University of Agricultural Sciences (SLU)

Link to the recording on YouTube.

Link to the presentation slides.

More info
This event is part of the SciLifeLab Data Management seminar series, an event series by the SciLifeLab Data Centre and NBIS joint Data Management team.

The goal of the events in this seminar series is to provide interesting interactive seminars around topics related to Research Data Management and Open Science in general, and to foster discussions around best practices.

The events are open to everyone working at or affiliated with a Swedish research institute or university. We welcome all researchers, educational professionals, staff, RDM professionals, and others with an interest in life sciences, from all university levels. The events are informal and inclusive, so feel welcome to join and participate in our interesting discussions!

The events will be recorded and published openly after the seminars on the SciLifeLab YouTube channel.

Link to the recording on YouTube.

Link to the presentation slides will follow soon.More information about SciLifeLab Data Centre and NBIS joint Data Management seminar series: https://www.scilifelab.se/data/scilifelab-data-management-seminar-series/

For more information or inquiries, please contact: data-management@scilifelab.se

Imaging in Cell and Molecular Biology
2025-03-17 12:00 - 2025-03-18 15:00 | Ångström Laboratory, Lägerhyddsvägen 1, Uppsala, Sweden
The DDLS research area symposia series aims to engage and build a strong national scientific community around the DDLS research themes. Each of the four areas arranges two symposia per year. Everyone interested in data-driven research is welcome to take part. We want to bring together researchers, industry, and healthcare to foster collaboration and push the frontiers of data-driven life science.

The DDLS research area Expert Group in Cell and Molecular Biology invites all interested in Data-driven life science to meet, present, interact, and discuss Imaging in Cell and Molecular Biology.

The event will take place at Ångström Laboratory in Uppsala and will include presentations from international and national invited speakers and selected abstracts. The event is free of charge.

Date: March 17 – 18, 2025

Start: at 12:00 on March 17, with lunch and registration.

End: with lunch 12:20-13:15 on March 18.

Venue: Room Heinz-Otto Kreiss, Ångström Laboratory, Lägerhyddsvägen 1, 752 37 Uppsala. Find your way – Maze map link here!

Find your way: From Uppsala Central Station, take buss № 4 (place B4) to Polacksbacken (find timetables for Uppsala City buses here).

Poster session

The poster session starts at 17:10 with networking and refreshments. Find the poster list and abstracts below.

For accepted Posters, if you have registered for:

Paper/canvas poster: Hang your poster during the coffee break in Room 101136 (Evelyn Sokolowski).

Digital poster: Display your presentation in Room 101142 (next to Evelyn Sokolowski).

Pins will be available, and the poster boards will be marked with poster numbers.

List Posters Abstract v6Download

Company Exhibition

You will have the opportunity to meet with the following companies during the symposia:

Carl Zeiss AB

BioNordika AB

TdB Labs AB

Micromedic AB

Bruker Nordic AB

10x Genomics Sweden

Company contact Erika Erkstam, erika.erkstam@SciLifeLab.uu.se.

In compliance with GDPR regulations, conference participants may not be added to company newsletters, mailing lists, or similar subscriptions without their explicit consent.

Registration

The registration deadline is March 3. To avoid empty seats, registration will remain open until the event begins, BUT registering after March 3 requires you to write your name on a name tag at the on-site registration. Unfortunately, we cannot accommodate allergies or dietary preferences for those who register after March 3.

March 4: The event has reached full capacity, so a waiting list has been activated. If you sign up for the waiting list, you will automatically receive an email when a spot becomes available. You must accept within 24 hours to secure the spot. If you decline, the offer will go to the next person on the waiting list.

Registration

Cancellation

To minimize empty seats and food waste, you must cancel your registration if you are unable to attend the symposia. Cancel via the Confirmation email or send an email to events@scilifelab.se.

Invited speakers

Download the Speaker abstracts:

DDLS CMB SpeakersDownload

Marta Carroni, SU
Title of talk: Structural basis for bacterial protein disaggregation and proteolysis

Abstract: Protein homeostasis is meticulously maintained across all cells, spanning from archaea to humans. Any deviation from the equilibrium of the proteome, induced by stress or cellular aging, leads to the accumulation of misfolded proteins, contributing to cellular toxicity. A complex proteostasis network actively manages misfolded proteins through processes such as refolding, degradation, or sequestration into intracellular inclusions. Integral to this protein quality control system are ATPases from the AAA+ superfamily (ATPases Associated to a variety of cellular Activities).

These AAA+ proteins, universally present in organisms, share a common structural fold for ATP hydrolysis, but each possesses distinct function-specific domains, enabling specialization in particular cellular activities and interactions with regulatory protein partners.

Our work focuses on the structural investigation of bacterial Hsp100 AAA+ chaperones involved in protein quality control. We aim at understanding their fine-tuned regulation, which is absolutely required by the bacterium to survive harsh environment conditions and useful for us in the effort of killing pathogenic bacterial strains. Using cryo-EM in combination with biochemical functional assays, we can describe the molecular tuning mechanisms used by bacteria to assure the disaggregation or proteolysis of toxic protein species only, while leaving intact functional protein molecules.

Bio: Marta Carroni is the Head of the Swedish National Cryo-EM Facility at SciLifeLab in Stockholm, whose start and development she drove since its institution in 2016. She is a trained structural biologist and more specifically an expert in cryo electron microscopy (cryo-EM), technique on which she received extensive training since 2007 first at Imperial College London and then at Birkbeck College London, under the supervision of Helen Saibil. Marta Carroni has initiated and trained in electron microscopy and image processing a large number of researchers in Sweden and abroad; she is often invited as teacher at cryoEM symposia and workshops. For this contribution, she has been named one of the female innovators by the Italian Association of Women Inventors and Innovators in 2018 and awarded the Hugo Theorell price in 2023. Since 2020, she is also the director of the Cellular and Molecular Imaging platform at SciLifeLab where she oversees the integration between different imaging modalities. Since 2022, thanks to fundings form KAW, SSF and support from Stockholm University, she can run independent research projects with her group, composed of 2 PhD students and 2 postdocs, mainly looking at AAA+ molecular motors and their regulatory mechanisms in bacterial and human systems. The group often hosts master and Erasmus students and, while developing an independent research path, fosters many collaborations in Sweden and abroad.

Jan Ellenberg, Director SciLifeLab
Title of talk: Quantitative Imaging of Protein Networks and Genome Structure in Single Human Cells and an Outlook on Alpha Cell

Abstract: The rapid development of new imaging technologies allows unprecedented insights into the molecular machinery inside living cells and organisms. For the first time, light and electron microscopy have molecular sensitivity and resolving power in situ, and, if used together, can connect structural detail with molecular dynamics of the whole cell. Aided by machine learning driven image analysis powered by open sharing of image data, this provides unprecedented opportunities for new insights into the molecular mechanisms that drive life’s core functions at the scale of the cell.

I will present the progress we have made to study one of life’s most fundamental functions, cell division, by mapping the dynamic protein network, assembly of individual protein complexes and genome re-folding that drive it. Our work has studied cell division in human cancer cells and early mammalian embryos using advanced cross-scale imaging methods, including light-sheet, quantitative fluorescence correlation spectroscopy (FCS)-calibrated, super-resolution and correlative light and electron microscopy. The quantitative integrated molecular data that these new technologies deliver, allow us to better understand how the molecular machinery functions in space and time to ensure faithful cell division and prevent the errors that underlie congenital disease, infertility and cancer.

Bio: Since July 2024, Professor Ellenberg is appointed Director of SciLifeLab. Jan Ellenberg is distinguished for many contributions to the cell biology and imaging field. The majority of these were made at the European Molecular Biology Laboratory (EMBL) where he is Senior Scientist and Head of the Cell Biology and Biophysics Unit. His major research contributions cover several aspects of the cell division cycle and nuclear organization, including systematic analysis of mitosis, nuclear pore complex structure and assembly, as well as chromatin organization and formation and segregation of mitotic and meiotic chromosomes.His goal has been to obtain structural and functional measures of the required molecular machinery inside cells using quantitative 4D imaging, single molecule spectroscopy, as well as light sheet and super-resolution microscopy, which his group is constantly developing and automating to address all molecular components comprehensively.

Anja Hauser, DRFZ, Germany
Title of talk: Functional, multidimensional optical microscopy to analyze the function of myeloid cells during bone regeneration

Abstract: Focusing on bone regeneration after injury, we aim to understand how the tissue microenvironment affects the metabolism of myeloid cells in the bone marrow over time, and how that impacts on cell function. We previously demonstrated that CX3CR1+ myeloid cells act as trailblazers for osteogenic type H vessels in the bone marrow. In order to analyze this process in 3D, we developed a tissue clearing, staining and light sheet fluorescence microscopy imaging pipeline called MarShie, optimized to image the entire intact femur at subcellular resolution down to the deepest bone marrow regions. To analyze the three-dimensional dataset, we applied a machine learning approach, enabling us to segment thousands of cells. We find that during homeostasis CX3CR1+ myeloid cells localize in perivascular niches, whereas CD169+ myeloid cells are dispersed in the parenchyma. After injury, CX3CR1+ myeloid cells relocate and sequester the injury site prior to vascularization. Analysis of the femur after full osteotomy reveals that vessel sprouting is initiated at periosteal regions.Phenotypes and functions of immune cells are tightly linked to their metabolic profiles, which in turn is affected by changes in the tissue microenvironment. We developed a lens implant for longitudinal intravital imaging of the mouse femur, to enable micro-endoscopic fluorescence lifetime imaging (FLIM) for metabolic profiling at the same tissue region over the whole time course of bone healing. Using a reference system of fluorescence lifetimes derived from the ubiquitous metabolic co-enzymes NADH and NADPH (NAD(P)H), we can determine enzymatic activities in vivo. This approach allows us to identify a high degree of dynamics in dominant metabolic pathways for energy production. Additionally, we distinguish pathways associated to cellular function and cellular state, i.e. oxidative burst (NADPH oxidase activity) and dormancy or death. Under in vivo conditions, myeloid cells with various metabolic profiles, i.e. using other pathways for energy production than the anaerobic pathway associated with pro-inflammatory cells, perform the oxidative burst necessary for phagocytosis. This demonstrates that a high metabolic flexibility of myeloid cells in vivo.

Bio: Anja Hauser holds the Professorship for Immune Dynamics at Charité – Universitätsmedizin Berlin, and is head of Program Area “Cell and Tissue Immunology” at Deutsches Rheuma-Forschungszentrum Berlin, Germany.Anja is a trained veterinarian who received her degree at the Tierärztliche Hochschule Hannover, Germany. During her PhD thesis, she investigated microenvironmental conditions that promote plasma cell longevity in tissues and became interested in the spatial organization of immune cells. Her postdoctoral work at Yale University School of Medicine focused on the dynamics of germinal center B cells, which she analyzed by intravital microscopy. Since founding her own laboratory, she has broadened her focus from the analysis of B cells to other adaptive and innate immune cells, with a particular focus on the analysis of immune-stroma interactions and the signals that maintain chronic inflammation.Thus, her work is centered around the basic concept that the immune system is organized in a spatial and temporal manner. To that end, she develops and applies advanced imaging technologies. Anja is founding member of the European Society for Spatial Biology.

Sverker Holmgren, Data Science Node, Chalmers
Title of talk: National Data Services for Imaging in Cell and Molecular Biology

Abstract: The Gothenburg DDLS Data Science Node is developing and deploying national services for managing and analyzing images in CMB. The node works together with the SciLifeLab Data Center, and the areas covered are selected jointly with the DDLS Expert Group in CMB. Currently, a national Open Microscopy Environment service (OMERO) for image data management and storage is being deployed, and this will be connected to High Performance Computing resources for analysis, using e.g. AI models, and later also to image repositories for preservation and open sharing. In the next phase, the underlying work setting up this national service is used to develop and deploy two other sets of prioritized services.

Bio: Sverker Holmgren is the Director of Chalmers e-Commons at Chalmers University of Technology, where he is also a Professor of Scientific Computing. Chalmers e-Commons is Chalmers’ digital infrastructure for research, providing integrated support to Chalmers researchers with a focus on data management, analysis, and data publication. Together with Chalmers Facility for Computational Systems Biology, Chalmers e-Commons hosts the Gothenburg DDLS Data Science Node in Cell and Molecular Biology. Chalmers e-Commons is also the Chalmers node in other selected national and international digital infrastructures and initiatives, e.g. the National Academic Infrastructure for Supercomputing (NAISS), the Swedish National Data Service (SND), and the National Research Infrastructure for Data Visualization (InfraVis).

Holmgren has a long history of engaging in data and large-scale computing infrastructures locally, nationally, and internationally. Besides leading the local effort at Chalmers, he is a member of national and international reference groups and initiatives on data management. Holmgren is a permanent Expert in the Swedish Delegation to the European Strategic Forum for Research Infrastructure (ESFRI), a member of the ESFRI IG, and a Swedish Delegate in the European e-Infrastructure Reflections Group (e-IRG). Earlier, Holmgren held a professorship at Uppsala University where he also served as the Dean of Mathematics and Computer Science for six years.

Rasmus Krogh Norrild, DTU, Denmark
Title of talk: High-throughput experimental approaches for quantifying the thermodynamics of biomolecular condensate formation

Abstract: Biomolecular condensates (BMCs) are phase-separated and membraneless compartments enriched in specific biomolecules, playing key roles in biological function and disease. Understanding how BMC formation depends on solution conditions, amino acid sequence, and nucleotide sequence is crucial, particularly for applications in drug discovery. High-throughput methods are therefore highly valuable for large-scale screening and for elucidating the fundamental driving forces of condensate formation. In this seminar, I will present Condensate Partitioning by mRNA-Display (CPmD), a novel high-throughput approach based on mRNA display (Norrild et al., bioRxiv 2024). CPmD enables the simultaneous analysis of partitioning behaviour for tens of thousands of peptides and their corresponding synthetic mRNAs within BMCs, offering new insights into the thermodynamics of condensate formation. To validate CPmD, we employed two microfluidics-based methods, Capflex (Stender, Ray, Norrild et al., Nat. Commun. 2021) and TDIPS (Norrild et al., Angew. Chem. Int. Ed. 2024), both leveraging the commercially available FIDA1 microcapillary system. These methods demonstrate how proteome-scale CPmD data on peptide partitioning can directly inform on biomolecular condensate formation of the proteins from which the peptides originate.

Bio: I am a postdoctoral researcher at the Technical University of Denmark (DTU), specializing in protein biophysics. I have a MSc in Biochemistry from the University of Copenhagen and I did my PhD in Biophysics at DTU on Biophysics. My research focuses on understanding how protein structure, stability, and phase behavior contribute to cellular function and disease. I combine experimental and data-driven computational approaches to study and engineer dynamic proteins, especially intrinsically disordered regions of these. My goal is to integrate quantitative biophysics with cell biology to uncover new insights into protein function in complex biological systems.

Wei Ouyang, DDLS Fellow, KTH
Title of talk: Unleash the Power of Generative AI for Data-Driven Cell Biology

Abstract: This talk presents the ongoing work of AICell Lab (https://aicell.io) focusing on developing generative AI, diffusion models for human cell modeling, and AI-driven automation in microscopy and robotics. We focus on the development of the REEF Microscopy Imaging Farm, which aims to create fully automated imaging systems that generate high-quality datasets for cell simulation. We are also building scalable platforms like ImJoy and Hypha, which power the BioImage Model Zoo—a community-driven repository enabling easy AI model testing. Additionally, our BioImage Chatbot, an AI agent built on a bioimaging knowledge base, is being extended for automated scientific discovery. These efforts converge in the Hypha platform, connecting hardware, AI models, and users to advance whole-cell modeling and redefine in-silico research and drug discovery.

Erdinc Sezgin, KI
Title of talk: Physical properties of cells and nanoscale bioparticles as new biomarkers of health and disease

Abstract: Remodelling of our cells as response to environmental changes is essential for their survival and function. Although numerous studies aimed at finding protein markers during such cellular processes, there is a major gap in our understanding of how collective biophysical properties of the cells (such as stiffness, membrane fluidity, viscosity etc) alter during these crucial biological processes. Similarly, our understanding of how biophysical properties of cells change in diseases is also limited. To gain a thorough mechanistic perception of cellular processes and diseases, it is essential to fill this gap and have a clear and quantitative picture of biophysical remodelling of the cells.We and others have made extensive effort to unravel the biophysical aspects of cells in a quantitative manner. To achieve this, we developed advanced imaging approaches that could reveal the molecular details with very high spatiotemporal resolution. These technologies allowed us to see how biophysical properties of cells play crucial roles for signalling from molecular to cellular level. Although these technologies were extremely useful to study biophysical aspects of cellular life at the molecular level, their low sampling (one cell at a time) has been a major obstacle to apply them to medical problems that require measuring thousands of cells. This can be overcome with high throughput methodologies that can robustly report on the ensemble biophysical properties of cells which require reliable reporters and instruments. Thus, while developing advanced instrumentation, we also develop reliable probes to quantify different biophysical properties of cells. Here, I will discuss our approach from probe development to high throughput biophysical analysis

Bio: Erdinc Sezgin studied Genetics and Bioengineering at the Yeditepe University, Istanbul Turkey. He next joined International Max Planck Research School for PhD in Dresden, Germany. After graduation, he obtained EMBO, Marie Curie and Newton fellowships to perform his postdoctoral research in immunology and imaging at University of Oxford. Since 2020, he has been leading his independent lab as an Associate Professor at Karolinska Institutet and SciLifeLab. He is currently an EMBO Young Investigator and a Visiting Faculty at University of Oxford.

Eduardo Villablanca, KI
Title of talk: Unraveling the Molecular Architecture of the Intestinal Barrier: Insights from Spatial Transcriptomics

Abstract: The complex cellular network that constitutes the intestinal barrier is crucial for maintaining health and preventing diseases. In this talk, I will present the remarkable capabilities of spatial transcriptomics (ST) in unveiling the molecular organization of the entire colonic tissue during mucosal healing and tumorigenesis. By leveraging ST, we revealed a previously undiscovered regionalization of the colon’s transcriptomic landscape under steady state conditions, which undergoes dramatic changes during mucosal healing. We identified spatially organized transcriptional programs that define compartmentalized mucosal healing, including regions exhibiting dominant wired pathways. Furthermore, I will discuss the translational potential of our findings by mapping transcriptomic modules associated with human diseases.

Bio: Dr. Villablanca is a developmental biologist turned immunologist with expertise in cell migration and mucosal immunology. He began his research using zebrafish as an in vivo model before shifting his focus to immunology during his PhD in Molecular Medicine at San Raffaele University in Milan, Italy. His interest in intestinal leukocyte trafficking led him to Harvard Medical School, where he trained as a postdoctoral fellow in Dr. Rodrigo Mora’s lab. After four years, he was promoted to Instructor in Medicine and joined Dr. Xavier’s lab to study inflammatory bowel disease (IBD) risk genes and their role in intestinal immune homeostasis.In late 2014, Dr. Villablanca was recruited to establish his own laboratory at the Karolinska Institute’s Division of Immunology and Respiratory Medicine in Sweden. Now a Professor of Gastrointestinal Immunology, Wallenberg Fellow, and ERC awardee, he leads a research team integrating developmental biology, mucosal immunology, and systems biology to uncover how intestinal homeostasis is maintained and how its disruption contributes to disease.Visit the Villablanca lab webpage here or watch the research video summary here.BsKy: @ejvillablanca.bsky.social

For questions about the Program, please contact the Scientific Committee:

Ida-Maria Sintorn, UU

Marc Friedländer, SU

About the event, please contact Project leader: Erika Erkstam, Operations office, SciLifeLab

Program

DDLS-Symposium-PROGRAM-NY2Download

More information about the Data-driven Life Science Research area

DDLS Cell and Molecular Biology

PULSE Challenge: Selection and screening of antibody based drugs
2025-03-17 13:00 - 14:00 | Online event via Zoom
This presentation will provide an overview of the selection and screening processes, as well as future challenges for antibody-based drugs. It will be exemplified with data from one of Alligator Bioscience’s bispecific antibody drug candidates, ATOR-4066. ATOR-4066 is a novel bispecific antibody constructed in the RUBY™ format using Alligator Bioscience’s Neo-X-Prime platform. It targets the tumor-associated antigen CEA (CEACAM5) on tumor cells and CD40 on myeloid cells. ATOR-4066 is designed to induce efficient CEA-conditional activation of myeloid cells, facilitate the uptake of neoantigen-containing tumor-derived material, and subsequently drive the cross-priming of tumor-specific T cells, resulting in long-lasting anti-tumor activity.

The seminar series PULSE Challenge is connected to the MSCA co-funded* postdoctoral program SciLifeLab PULSE, that will train 48 future leaders in life sciences. The program focuses on innovative, fundamental and translational research carried out in supportive and diverse academic and industrial environments, preparing postdocs with necessary skills for long-term career sustainability. Click HERE to find out more about SciLifeLab PULSE

On-line event via Zoom

Register Here

Presenter: Dr Peter Ellmark, PhDChief Scientific OfficerAlligator bioscience, Lund, Sweden

Abstract:Antibody-based drugs have revolutionized the treatment landscape for numerous serious conditions, with a global market size exceeding $250 billion. The success of these drugs can be attributed to their high specificity and versatility. Critical to the successful development of antibody-based drugs is the appropriate selection and screening methodology, which ensures that drug candidates meet all key criteria for successful development.

A short speaker biography:Peter Ellmark joined Alligator Bioscience in 2008 and serves as Chief Scientist. He holds a PhD and an adjunct professorship in Immunotechnology at Lund University and has more than 20 years’ experience of developing antibodies for immunotherapy of cancer. Dr. Ellmark´s research interest is focused on developing mono- and bispecific antibodies, in particular CD40 and 4-1BB targeting therapies, for tumor directed immunotherapy of cancer.

Advancing biomarker discovery with innovative omics technologies
2025-03-18 13:00 - 15:00 | Birgit Thilander Lecture Hall, Medicinaregatan 3, Göteborg
Takara Bio Europe, in collaboration with Clinical Genomics Gothenburg, invites you to explore their latest NGS technologies, enjoy insightful talks from guest speakers, and discover how their innovations are driving cutting-edge research!

Agenda and speakers

Dr Joan Camuñas-SolerAssistant Professor, Dept. of Medical Biochemistry & Cell Biology, WallenbergCenter for Molecular and Translational Medicine, University of Gothenburg• Predictive RNA profiles for lung involvement in systemic sclerosis

Dr Florian PaaschNGS Sales Specialist, Takara Bio Europe• Total RNA-seq from clinical samples

Dr Matthieu PesantSr Market Strategy Manager, Translational Genomics, Takara Bio Europe• New single-cell omics technologies for biomarker discovery• Enabling long-read mRNA-seq for biomarker discovery using limited clinical sample inputs

Registration

Register here: Takara Bio | NGS Innovation TourOnline participation via Teams is possible. Please, contact Beatrice Westman (beatrice_westman@takarabio.com) for the link.

Current Trends in Applied Mass Spectrometry
2025-03-19 09:00 - 2025-03-20 16:30 | KBC Building Umeå, Linneaus Väg 6, Umeå
This event is a forum where people from industry, academia and research infrastructures can meet and discuss the latest developments in Applied Mass Spectrometry. The event consists of several workshops, a conference and a fair where leading companies in the field will present their latest analytical applications and technologies.This event includes a workshop day on 19 March and a conference and a fair on 20 March. The event ends with a dinner on 20 March.

Important dates:

Monday, 3 March at 23:59 – registration deadline for the Workshops on 19 March

Thursday, 6 March at 23:59 – registration deadline for the Conference and Fair on 20 March.

After 6 March, you can register for the conference, but not for the lunch.

OrganizersThe event is organized by the Swedish Mass Spectrometry Society (SMSS), the Swedish Metabolomics Centre (SMC), and SciLifeLab in collaboration with the Mass Spectrometry Network Umeå and the participating companies. The KBC Communications Office and Umeå University Library provide organisational support.

Precision phenotyping in dilated cardiomyopathy
2025-03-21 09:00 - 09:40 | Online event via Zoom
Charlotta Ljungman, Senior consultant

This Clinical talks has been rescheduled – from February 28 to March 21. Any prior registrations remains valid.

Charlotta Ljungman is senior consultant and associate professor in cardiology working at Sahlgrenska University Gothenburg.

Her research involves aspects of heart failure and cardiomyopathy and she is the founder of Sahlgrenska Cardiomyopathy Center. She is also the chair of the Swedish heart failure registry (Swede-HF)

register to receive zoom link

Abstract

Precision phenotyping has been suggested to find new subtypes and biomarkers in heart failure and dilated cardiomyopathy (DCM), the most common cardiomyopathy, and were the cause in 50% of the cases is unknown. Therefore, the aim of this project is to combine proteomics and metabolomics to:

Understand cardiac energy metabolism in heart failure and DCM.

Find subtypes and biomarkers by multimodal precision phenotyping with proteomics and integration of data

Once established, the precision phenotyping approach may allow identification of patients/subtypes at greatest risk, find new biomarkers and allow intervention and personalized follow-up of high-risk individuals.

The aim will be achieved by investigating cardiac energy metabolism (uptake and release) and proteomic profile in relation to cardiac function at rest and during exercise, in patients in comparison to healthy controls. Patients undergoing right heart catheterization (RHC) with the diagnosis of heart failure and DCM without metabolic disease are included in a prospective mechanistic case control study of cardiac energetics; the MEtabolic CHAracterization of patients with Dilated cardiomyopathy (MECHAD) study. Age and sex matched controls without heart failure undergoing electrophysiological examination are included. Arterial blood supply tissues and organs with oxygen and metabolites for energy and venous blood carry the metabolic by-products and carbon oxide from tissues and organs. This allows to calculate uptake and release of metabolites and oxygen through arteriovenous approach by simultaneous sampling in artery (to the heart) and the coronary sinus (from the heart) when performing RHC and calculate cardiac energy metabolism and collect samples for proteomics profiling. Patients undergo clinical examinations including medical history, alcohol use disorders identification test, Kansas City Cardiomyopathy Questionnaire, ECG, blood pressure, Transthoracical echocardiography (TTE) and Cardiopulmonary exercise testing (CPET). All patients are followed for 12 months.

Clinical Talks returns with a new season!

After seven successful seasons and over seventy dedicated speakers, we are excited to continue showcasing the contributions of our diverse clinical, academic, and industry Life Science community. This season will feature ten insightful talks, following our well-established format.

The overarching theme is “How to Achieve Feasible Implementation.” Sessions will be held monthly on Fridays from 09:00 to 09:30 am via Zoom, with occasional exceptions. Each talk will be followed by an engaging Q&A session, moderated by standing host Rikard Fred, alongside a guest moderator with subject matter expertise to enrich the discussion.

In today’s rapidly evolving post-pandemic landscape, it is crucial to explore how academic, clinical, and industry research—combined with technological advancements—can drive practical and sustainable solutions. Join us for an opportunity to gain fresh insights, expand your knowledge, and connect with experts shaping the future of Life Sciences!

Clinical Talks are organized by the SciLifeLab’s Precision Medicine Capability

Umeå seminar series: Powder X-ray diffraction in geochemical, environmental, and energy sciences
2025-03-25 12:00 - 13:00 | KBC Building, Linneaus Väg 6, Umeå, Sweden
“Powder X-ray diffraction in geochemical, environmental, and energy sciences – identifying and quantifying crystalline structures using the MAXS platform”Speaker: Nils Skoglund, MAXS platform manager and Associate Professor at Thermochemical Energy Conversion Laboratory, Department of Applied Physics and Electronics, Umeå University.

Target audience: PhD students, post-docs and PIs working with solid samples related to geology, sediments, environment, or energy sciences.

Platform’s webpage: Multi-purpose Adaptive X-ray Scattering platform (MAXS)

Registration: Sign up for the IRL seminar and reserve your free lunch (salad, drink, and little sweet snack) by Friday, 21 March, 12:00, or follow online (registration is not required):Meeting URL: https://umu.zoom.us/j/69390567429

Register

SciLifeLab Site Umeå/KBC Infrastructure Seminar Series

This event is part of the SciLifeLab site Umeå/KBC Infrastructure Seminar series, for future events in spring 2025, check the seminar series home page.

Take me there

Making toxicology tools more accessible and interoperable
2025-03-26 11:00 - 2025-03-27 15:00 | BMC Trippelrummet, Husargatan 3, entrance C11, Uppsala, Sweden
This workshop (for up to 40 participants) is a face-to-face, free-of-charge hands-on workshop, organised in the context of the first implementation study (INTOXICOM) of the ELIXIR Toxicology Community. See the ELIXIR Toxicology Community Whitepaper for more in-depth information about the community’s goals.

Several projects, such as NanoSolveIT, ONTOX, and VHP4Safety, already make computational toxicology services available. In this workshop, we will cover various aspects of making computational tools available and how they are used.

The first session will focus on what tools currently exist and how they relate to ELIXIR Europe. This session will be user-centric and will give an overview of what is available and how ELIXIR solutions like FAIRsharing and bio.tools can be used to find tools and what information about the tools they provide.

The first day continues with a session bridging data with the tools. This session is user-centric with experimental toxicologists, explaining how their data can integrate with these computational tools. For example, how data hosted on Figshare can be used in tools, or how computational workflows can bridge data repositories with computational tools.

The second day continues with a session on how computational tools can address data gaps and enhance experimental toxicology data. Topics in this session are expected to explain how computational solutions help give biological and toxicological context, how AI is used for predictions, and how large language models may help with literature research.

TARGET AUDIENCE

Toxicologists who are interested in learning more about computational toxicology and how it can be used for and with their experimental data.

WHEN

Day 1: Wednesday 26.03. from 11h to 18h & subsequent social dinner

Day 2: Thursday 27.03. from 9h to 15h

WHERE

BMC TrippelrummetHusargatan 3, entrance C11751 22 Uppsala

Read more and join the workshop

CONTACT INFO

This workshop is organised by:

Egon Willighagen (Maastricht University, Netherlands, egon.willighagen@maastrichtuniversity.nl)

Ola Spjuth (Uppsala University, Sweden, ola.spjuth@uu.se)

Antreas Afantitis (Cypress)

Andreas Tsoumanis (Greece)

SciLifeLab Lund Seminar Series | LBIC
2025-03-26 15:00 - 16:00 | Belfragesalen, BMC D15, Klinikgatan 32, Lund, Sweden
Welcome to the SciLifeLab Lund seminar series!

These seminars are designed to highlight SciLifeLab Lund, our cutting-edge research infrastructure, and the diverse resources available to the scientific community.

In the 6th seminar, we will have a look into the Lund University Bioimaging Centre (LBIC), an infrastructure within the Medical Faculty at Lund University, housing a large variety of advanced imaging equipment and cutting-edge bioimaging techniques ranging from micro to macro.

The session will begin with an overview of LBIC and its advanced capabilities, followed by a user presentation showcasing a project that leveraged the unit’s expertise to achieve impactful results.

Please note that the seminars are site only but the recordings are available HERE.

Registration

Register for the next seminars!

23rd April 2025 | Lund Protein Production Platform

Register Seminar April

28th May 2025 | National Bioinformatics Infrastructure (NBIS)

Register Seminar May

18th June | Structural Proteomics

Register Seminar June

PLOS and SciLifeLab Webinar: Navigating Open Science Policies – Practical Guidance for Researchers on Sharing Data and Software
2025-04-03 13:00 - 14:00 | Online event via Zoom
Open science policies are rapidly evolving, but many researchers find them to be vague and difficult to navigate. These policies often lack clear, actionable guidelines for how researchers can respond to requirements while ensuring they meet research community, national, and international standards. This webinar will briefly summarise the current landscape of selected open science policies. Through real-world examples from PLOS and SciLifeLab, attendees will gain practical insights into how these policies are being implemented and how to align their work with both institutional and national requirements and monitoring initiatives. The session will offer valuable tools and strategies for ensuring compliance and promoting open science practices in a way that is both manageable and impactful.

Time is in CEST

register here

Link to the recording on YouTube

Link to the slides on SciLifeLab Data Repository

Presenters:

Nonia Pariente, Editor-in-Chief, PLOS Biology

Agata Morka, Regional Director, Publishing Development (Europe) at PLOS

Christopher Erdmann, Head of Open Science, SciLifeLab

Co-hosts:

Parul Tewatia, Project coordinator (FAIR Metadata and Semantic Technologies), SciLifeLab

Suné Joubert, Project coordinator (Open Science Communities and Metrics), SciLifeLab

Organizers:

This event is co-hosted by SciLifeLab and PLOS.

[The Svedberg seminar]-Navigating Lipid Metabolism: From Basic Molecular Mechanisms to Cellular Symphony
2025-04-07 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Aditi Das

Professor School of Chemistry and Biochemistry Georgia Institute of Technology, USA

Bio

Dr. Aditi Das is a Professor in the School of Chemistry and Biochemistry at Georgia Institute of Technology (Georgia Tech). Her research explores lipid biochemistry, enzymology, and drug metabolism, with a focus on bioactive metabolites and their roles in inflammation and neurodegenerative diseases. She earned her Ph.D. in chemistry from Princeton University, specializing in functional protein design, followed by postdoctoral research utilizing biophysical tools to study membrane proteins in Nanodiscs. Dr. Das has made significant contributions to understanding cytochrome P450 enzymes and their role in lipid oxidation, leading to advances in drug discovery and biomedical applications. Her work has been widely published in high-impact journals, and she has received numerous grants and awards. Her national accolades include the NIH R35 Outstanding Researcher Award, the E.L.R. Stokstad Award, and the Mary Swartz Rose Young Investigator Award from the American Society for Nutrition. Beyond her research, she serves on the Editorial Advisory Boards of Molecular Pharmacology and Frontiers in Pharmacology. Through her work, Dr. Das continues to advance the fields of lipid biochemistry and cannabinoid metabolism, translating fundamental science into real-world applications for human health.

Navigating Lipid Metabolism: From Basic Molecular Mechanisms to Cellular Symphony

Lipids are vital for cellular functions, acting as structural components, signaling molecules, and energy sources. Their metabolism, particularly through cytochrome P450s and other oxidizing enzymes, plays a key role in inflammation and disease. This study uses biochemical, analytical, and biophysical methods to examine the metabolism of endocannabinoids and cannabinoids by membrane-bound cytochrome P450s, stabilized in nanoscale lipid bilayers (Nanodiscs). The pharmacological properties of lipid metabolites are evaluated, focusing on their impact on inflammation and pain receptor modulation. The study also explores the metabolism of minor cannabinoids like cannabinol (CBN), cannabigerol (CBG), and cannabichromene (CBC), which provide medicinal benefits without THC’s psychoactive effects. Computational modeling helps further understand binding mechanisms, and in vitro studies confirm the bioactivity of these metabolites. This integrated approach enhances our understanding of lipid metabolism and cannabinoid pharmacology, supporting the development of therapeutic strategies for pain and inflammatory diseases.

Host: Peter Kasson peter.kasson@icm.uu.se

Umeå seminar series: Beyond the Command Line - HPC2N and the OpenOnDemand Experience
2025-04-08 12:00 - 13:00 | KBC Building Umeå, Linneaus Väg 6, Umeå
“Beyond the Command Line – HPC2N and the OpenOnDemand Experience”

Speaker: Björn Torkelsson, System engineer and Assistant director, High Performance Computing Centre North (HPC2N)

Abstract: This presentation will provide an update on the latest developments at HPC2N. We will explore recent enhancements in infrastructure, software, and services offered to researchers and users.

A significant portion of the presentation will be dedicated to a live demonstration of OpenOnDemand, a web-based portal that simplifies access and utilization of Kebnekaise, the local UMU HPC resource. We will showcase how OpenOnDemand enables easy execution of applications, data visualization, and job management directly from a web browser, enhancing accessibility and efficiency for users of all levels.

Webpage of High Performance Computing Centre North (HPC2N)

Registration: Sign up for the IRL seminar and reserve your free lunch (salad, drink, and little sweet snack) by Friday, 4 April, 13:30: https://www.umu.se/en/research/infrastructure/scilifelab/scilifelab-site-umea–kbc-infrastructure-seminar-series

Follow the seminar online (registration is not required): Meeting URL: https://umu.zoom.us/j/69390567429

Innovation Through Collaboration
2025-04-08 14:00 - 16:00 | Gamma 2 Lunchroom, SciLifeLab, Tomtebodavägen 23, Solna, Sweden
Innovation Through Collaboration:AstraZeneca Open Innovation & Collaborative Insights from Malin Wickström & Arne Östman from Karolinska InstitutetBjörn Tyberg, PhD and PIpresents AstraZeneca Open Innovation

TOPICS TO BE COVERED

CoSolve challenges

Preclinical compound sharing

Compound screening collaborations: Diversity screens, Phenotypic screens, Bespoke library screens and Secretome & other libraries

Time will be given afterwards for 1:1 project discussions with interested investigators. To book a time slot, please contact per.moberg@ki.se

We will meet up with individuals who do not have access to SciLifeLab at the reception at 13:55

To book a time slot, please contact per.moberg@ki.se

Clinical Genomics 10th Anniversary Symposium – Genomic technologies transforming precision diagnostics
2025-04-10 09:00 - 2025-04-11 17:00 | Conference Centre Wallenberg, Medicinaregatan 20A, Gothenburg, 413 90, Sweden
Celebrate a Decade of Innovation in Clinical Genomics!

We’re thrilled to invite you to the 10th Anniversary Symposium of the SciLifeLab Clinical Genomics Platform. This milestone event, themed “Genomic Technologies Transforming Precision Diagnostics,” will be held April 10–11, 2025, at the Conference Centre Wallenberg in Gothenburg, Sweden.

This symposium marks ten years of progress in personalized medicine and genomic research. It will gather leading experts to explore groundbreaking advancements and discuss the future of clinical genomics, oncology, and precision diagnostics.

This event offers an excellent chance to engage with thought leaders, exchange ideas, and gain insights into the innovations shaping the future of medicine. Save the dates and join us in Gothenburg this April to celebrate a decade of progress and discovery!

Key Topics

Current and Emerging Next-Generation Sequencing Technologies

Translational Single Cell and Spatial Omics

Genomics for Pathogen Detection and Pandemic Preparedness

Diagnostic Analytics and Informatics

The Future of Genome-Based Diagnostics and Medicine

The event will also feature exhibitions and presentations by leading companies in genomic technologies, showcasing their innovations and expertise.

Program

CG_10years_ProgramDownload

Conference booklet

CG10Y_ConferenceBooklet_digitalDownload

Confirmed speakers

View speakers

Annika Jenmalm Jensen

Infrastructure Director at SciLifeLab and researcher at Karolinska Institutet.

Helene Cederroth

Co-founder and president of the Wilhelm Foundation. Board member of the Undiagnosed Diseases Network International

Valtteri Wirta

Platform Scientific Director at Clinical Genomics Stockholm. Head of Office, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet.

Lars Feuk

Co-Director of the SciLifeLab National Genomics Infrastructure and Professor at Uppsala University.

Lars Engstrand

Professor and senior physician at Karolinska Institutet, directs the Centre for Translational Microbiome Research.

Richard Rosenquist Brandell

Professor of Clinical Genetics at Karolinska Institutet and Senior Physician at Karolinska University Hospital, Director of Genomic Medicine Sweden.

Joakim Lundeberg

Professor of molecular biotechnology at KTH Royal Institute of Technology, renowned for developing Spatial Transcriptomics.

Olli Dufva

Physician-scientist and postdoctoral fellow at the Wellcome Sanger Institute, with expertise in computational analysis and functional genomics.

Mikael Benson

Principal researcher at Karolinska Institutet, leading the Medical Digital Twin Research Group.

Matt Brown

Professor at King’s College London and Chief Scientific Officer at Genomics England

Anders Ståhlberg

Professor in Clinical Genomics at the University of Gothenburg. Principal investigator at the Sahlgrenska Center for Cancer Research and the Wallenberg Centre for Molecular and Translational Medicine.

Tatjana Pandzic

Clinical laboratory geneticist and researcher at Uppsala University Hospital. Co-leads the hematology work package at Clinical Genomics Uppsala.

Rene Kaden

Associate Professor at Uppsala University’s Department of Medical Sciences, specializing in Clinical Microbiology.

Sofia Brunet

PhD student at Sahlgrenska University Hospital, with a background in clinical microbiology.

Göran Jönsson

Professor of molecular oncology at Lund University, specializing in melanoma research.

Jessica Nordlund

Researcher at Uppsala University’s Department of Medical Sciences, where she leads the Molecular Precision Medicine research group.

Araz Rawshani

Associate professor at the University of Gothenburg’s Institute of Medicine and a resident physician in cardiology at Sahlgrenska University Hospital.

Marcin Kierzcak

Bioinformatics data scientist at the National Bioinformatics Infrastructure Sweden (NBIS) and associate professor in bioinformatics at Uppsala University.

Confirmed exhibitors

View confirmed exhibitors
Gold Exhibitors

illumina

Integrated DNA Technologies

Oxford Nanopore Technologies

Roche Diagnostics Scandinavia

Silver Exhibitors

Parse BioSciences

Techtum Lab

Triolab

Bronze Exhibitors

10x Genomics

BioNordika and their supplier New England Biolabs

Bruker Spatial Biology

Hamilton Nordic AB

Nordic Biolabs AB and their supplier Promega

Proteintech Europe

Saveen & Werner

Takara Bio

Thermo Fisher Scientific

Organizing committee

View organizing committee
Thoas Fioretos, Platform Director, Clinical Genomics (until Dec 31, 2024); Lund University

Lucia Cavelier, Platform Co-Director, Clinical Genomics (until Dec 31, 2024); Uppsala University

Colum Walsh, Platform Director, Clinical Genomics (from Jan 1, 2025); Linköping University

Malin Melin, Platform Co-Director, Clinical Genomics (from Jan 1, 2025); Uppsala University

Marcela Davila, Platform Coordination Officer, Clinical Genomics; University of Gothenburg

Eva Berglund, Platform Strategy and External Relations Officer, Clinical Genomics; Uppsala University

Maria Smedh, Site Coordinator; University of Gothenburg

Accommodation

A block of rooms has been reserved for symposium attendees at Elite Park Avenue Hotel
Elite Park Avenue Hotel, is a centrally located hotel on Gothenburg’s main boulevard, Avenyn (Kungsportsavenyn), for the nights of April 9 and 10.

If you wish to stay at this hotel, please email reservations.gbgpark@elite.se and use “CG10years” as the booking code. If you prefer to pay by invoice, be sure to provide complete invoicing details, including information for e-invoicing. The room rates follow the governmental agreements (Kammarkollegiet).

The reserved rooms will be available until the end of March (5 weeks before arrival). After that, unbooked rooms will be gradually released, with all remaining reservations canceled 1 week before arrival.

Getting There

The easiest way to travel within Gothenburg is by tram,
and the most convenient way to pay is by using the Västtrafik ToGo app, which also includes a travel planner.

From the Elite Park Avenue Hotel

To reach the conference center from the hotel, take tram no. 7 from Valand (Track B) to Medicinaregatan. During rush hours, tram 7 departs every 6 minutes. You can download the timetable here. The total journey, including walking, takes approximately 20 minutes.

From Gothenburg Central Station

To get from the central train station to the conference center, take tram no. 1, 2, or 7 from Centralstationen (Track C) to Medicinaregatan. During rush hours, trams run every 2–4 minutes. The total journey, including walking, takes approximately 20 minutes.

Registration

Registration deadline: March 31, 2025

Innovation through collaboration
2025-04-10 12:00 - 13:00 | Galaxen (Sirius), Universum, Umeå, Universitetstorget 4, Umeå, 90187, Sweden
AstraZeneca Open Innovation and Collaborative Insights from Mikael Elofsson, UMU

Speakers: Björn Tyrberg and Hannah Semple present Open Innovation, AstraZeneca, covering:

– CoSolve challenges– Preclinical compound sharing– Compound screening collaborations:–> Diversity screens–> Phenotypic screens–> Bespoke library screens–> Secretome and other libraries

The presentation will be given in Galaxen (Sirius), found on the ground floor of the Universum building, at Umeå University. Find your way to the venue: MazeMap link.

Time will be given afterwards for 1:1 project discussions with interested investigators.

Register to come to the presentation and reserve your lunch, as well as book a 1:1 project discussion by Tuesday, 8 April at 10:00.

Read more and register here

CSI Seminar: Navigating Rejection in Academia
2025-04-10 14:00 - 14:30 | Gamma 2 Lunchroom, SciLifeLab, Tomtebodavägen 23, Solna, Sweden
Rejection is an unavoidable part of academic life – whether it’s a rejected manuscript, an unsuccessful grant application, or job market setbacks. But while rejection is common, it can still feel deeply personal and discouraging. Why does rejection sting so much, and how can we navigate the emotions and self-doubt that come with it? In this seminar, we’ll explore how common rejection in academia is, the psychological impact of academic rejection, strategies for maintaining resilience, and ways to reframe setbacks as opportunities for growth.

We will begin with a ~ 20 min talk, held in Solna and over zoom. Then proceed with a reflection and discussion held on-site. We encourage other sites to form watch parties, by listening in together to the talk and then hold their own discussion afterwards. Hopefully seeding many local chapters of CSI.

To help facilitate discussion and reflection, consider the following starter questions:

Awareness: where do we experience rejection in our lives already?

Analysis: how well do I currently interact with rejection?

Alternative: how could we relate to rejection in academia, for ourselves and others?

Action: how will knowledge of rejection in academia change my decisions going forward?

Bringing Cells to Life of the Computer: Whole-Cell Modeling from Minimal Bacteria to Human Cells
2025-04-16 10:30 - 11:30 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Speaker

Zane R Thornburg, PhD

Chemical Imaging and Structures Laboratory

University of Illinois Urbana-Champaign

Abstract

The goal of whole-cell modeling is to computationally predict the temporal progression of cell states. To simulate minutes to hours of biological time, we sacrifice atomic resolution and instead use coarse-grained hybrid simulations. In these models, large structures like membranes are projected onto a 3D cubic lattice, macromolecules like proteins are individual particles, and small molecules like metabolites are tracked as dynamic concentrations. Our most complete model is the genetically minimal bacterium in which we successfully simulate an entire cell cycle from start to division in 3D including the entire metabolic network and expression of its 493 genes. Organisms of more practical interest are significantly more complicated, and many challenges still need to be discovered and overcome to model them. I will present two ongoing efforts in the areas of cell metabolism and mRNA splicing. One of the greatest challenges in metabolic modelling is determining a set of kinetic parameters. We present a method to determine sets of thermodynamically realistic kinetic parameters for enzymatic reactions in whole-cell metabolic models. The fate of a eukaryotic cell depends on proper maturation of its pre-mRNA through splicing. Variations in splicing of pre-mRNA from a single gene (alternative splicing) result in multiple isoforms of mature mRNA, each producing a different protein with distinct biological activities. We model the kinetics of splicing to predict the frequencies at which the isoforms occur and demonstrate the model’s capabilities and limitations using known splicing isoforms from the human genome.

Contact: Erik Lindahl (erik.lindahl@scilifelab.se)

“It just works with my software” – How to adopt the FAIR principles in life science research at any career stage
2025-04-22 10:00 - 11:00 | Online event via Zoom
This seminar will explain why funders promote the FAIR principles and showcase how the principles are useful to you in projects and collaborations of any size. The FAIR principles are intended to support effective data sharing up to the degree that you can assert “It just works with my software”. But they apply equally well to the social aspects of data sharing and can serve as a guide to help you address the question “If I leave the lab today, how can my colleagues understand, find and use my data?”.

What you’ll learn:

Understand the FAIR principles (Findable, Accessible, Interoperable, and Reusable) and their importance in research.

Discover how adopting these principles can improve data sharing, collaboration, and long-term research impact.

Learn practical strategies to make your data FAIR—valuable and usable for years to come.

Who should attend?

Researchers and professionals at any career stage who aim to optimize their data management practices.

Why attend?

This seminar offers actionable insights to help you align with funder expectations, enhance research reproducibility, and maximize the value of your data.

Presenters: Wolmar Nyberg Åkerström and Niclas Jareborg (NBIS, SciLifeLab)

Link to the recording on YouTube.

Link to the presentation slides.

More info
This event is part of the SciLifeLab Data Management seminar series, an event series by the SciLifeLab Data Centre and NBIS joint Data Management team.

The goal of the events in this seminar series is to provide interesting interactive seminars around topics related to Research Data Management and Open Science in general, and to foster discussions around best practices.

The events are open to everyone working at or affiliated with a Swedish research institute or university. We welcome all researchers, educational professionals, staff, RDM professionals, and others with an interest in life sciences, from all university levels. The events are informal and inclusive, so feel welcome to join and participate in our interesting discussions!

The events will be recorded and published openly after the seminars on the SciLifeLab YouTube channel.

Link to the recording on will follow after the presentation.

Link to the presentation slides will follow after the presentation.More information about SciLifeLab Data Centre and NBIS joint Data Management seminar series: https://www.scilifelab.se/data/scilifelab-data-management-seminar-series/

For more information or inquiries, please contact: data-management@scilifelab.se

[The Svedberg seminar]-The origins and functional evolution of amniote sex chromosomes
2025-04-22 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Henrik Kaessmann

Professor of Evolutionary Genomics at Heidelberg , Germany

Bio

Dr. Henrik Kaessmann is Professor of Evolutionary Genomics at Heidelberg University. His research focuses on the molecular foundations of mammalian phenotypic evolution, leveraging various comparative and functional genomics approaches. After earning his Ph.D. at the Max Planck Institute for Evolutionary Anthropology, he conducted postdoctoral research at the University of Chicago as an EMBO Fellow. His interdisciplinary lab, which he initially established in Lausanne (Switzerland), has pioneered large-scale studies of gene expression changes and their phenotypic implications across various biological dimensions, including organs, species, developmental stages, gene expression layers, coding and noncoding gene types, splicing isoforms, and sexes. Prof. Kaessmann has published extensively in leading journals and has received numerous prestigious honors, including three ERC grants, EMBO membership, the Friedrich Miescher Award, and the Cloëtta Prize. Beyond his research, he teaches and mentors at Heidelberg University and maintains active collaborations with clinical researchers and major scientific institutions worldwide.Collectively, Henrik Kaessmann’s transformative work has profoundly advanced our understanding of the molecular foundations of mammalian phenotypic evolution and the driving forces of natural selection. The remarkable scope of his lab‘s major findings demonstrates how large-scale genomics approaches can yield fundamental biological insights and test key hypotheses. Notably, his interdisciplinary research has had far-reaching impact beyond evolution and development, as evidenced by extensive citations across diverse fields. His findings, including the observation of functional divergence of many genes between humans and mice, and unique gene expression (i.e., transcriptome, epigenome, translatome) datasets spanning key organs and developmental stages in humans and various model and non-model species, have become indispensable resources for biomedical research in general. To maximize their impact, his team has created interactive public databases that ensure optimal usability for the scientific community.

The origins and functional evolution of amniote sex chromosomes

In our lab, we carry out large-scale studies of gene expression changes and their phenotypic implications across various biological dimensions (e.g., species, organs, developmental stages, gene expression layers, coding and noncoding gene types, splicing isoforms, and sexes). In this seminar, I will focus on our endeavors to unravel the origins of the different amniote sex chromosome systems, which emerged from ancestral sets of autosomes. We have, for example, unveiled the origins of the sex chromosomes of therian (i.e., placental and marsupial) and monotreme mammals, and those of birds and lizards. We then scrutinized the evolutionary and functional consequences of sex chromosome differentiations (i.e., the degeneration of Y or W chromosomes in males or females, respectively) and the associated selective forces. Overall, our work has illuminated the evolution of the specific gene contents on the respective sex chromosomes, the origins and consequences of male (meiotic) sex chromosome inactivation, and the forces and mechanisms underlying the evolution of the various amniote dosage compensation mechanisms, including the drivers underlying the emergence of the female X inactivation mechanism in therians. I will present published and unpublished highlights of our work

Host: Leif Andersson leif.andersson@imbim.uu.se

KI-SciLifeLab symposium 2025
2025-04-23 12:00 - 18:00 | Andreas Vesalius Lecture Hall, Karolinska Institutet, Berzelius väg 3, Solna, 171 65, Sweden
Join us at the fourth annual KI-SciLifeLab symposium. This is a half-day event that aims to bring together members of the SciLifeLab community at KI and others interested in our work. The afternoon will feature a series of scientific talks, followed by a poster session and an opportunity to mingle.

Confirmed speakers

Andreas Luttens

Jan Ellenberg

William Nyberg

Stefanos Stagkourakis

Melis Anahtar

Konstantinos Georgiadis

Mikael Altun

Brinton Seashore-Ludlow

Kimmo Kartasalo

Read more

Registration

Program
11:30Registration and lunch12:30Greetings from KI managementMartin Bergö, Vice President Karolinska Institutet12:45Artificial intelligence for prostate computational pathologyKimmo Kartasalo13:00Navigating vast chemical spaces for drug discoveryAndreas Luttens13:15Greetings from SciLifeLab managementJan Ellenberg, Director SciLifeLab13:30In vivo CRISPR engineering to reprogram T cells13.45Title TBAStefanos Stagkourakis14:00Coffee break14.30Deep learning-enabled discovery of antibiotics for Neisseria gonorrhoeaeMelis Anahtar15:15Delineating tumor evolution dynamics in breast cancer by time-course single-cell copy number profilingKonstantinos Georgiadis15:30Title TBAMikael Altun15.50High content imaging in advanced models for functional precision medicineBrinton Seashore-Ludlow16:30Poster Session17:00Announcement of best poster price

Organisers
Kimmo Kartasalo kimmo.kartasalo@ki.se

William Nyberg william.nyberg@ki.se

Stefanos Argyrios Stagkourakis stefanos.stagkourakis@ki.se

Ann-Charlotte Zingmark ann-charlott.zingmark@ki.se

Data Management in Life Science
2025-04-23 13:00 - 2025-04-24 15:00 | Campus US, Digitalis, House 511, floor 11, Linköping
Registration Now Open

Register here

SciLifeLab Linköping together with SciLifeLab Data Centre and NBIS welcomes all life-science researchers (from master student to PI), data support, tech staff and infrastructure experts in Linköping to join this event where we explore the available support for research data handling and discuss on good data management practices according to FAIR principles and Open Science.

On-site event

PROGRAM

APRIL 23

13:00-14:00 Good Data Management Practices – available services and support

Here you will learn how to handle your research data according to FAIR principles and Open Science. The SciLifeLab Data Center, NBIS and several units at LiU is providing knowledge, tools and support in all life science data areas.

Linköping University and SciLifeLab, has signed the CoARA agreement along with many other universities and academic organizations all over the world. FAIR is the abbreviation for Findable, Accessible, Interoperable and Reusable.

This Open Lecture is for everyone in academia and health care handling research data

APRIL 24

9:00-10:00 FAIR breakfast for Master students, PhD-students and Postdocs
Here, young scientists join for breakfast and discussions on FAIR principles and how to handle research data. FAIR is the abbreviation for Findable, Accessible, Interoperable and Reusable. Knowledge in good research data handling from the very beginning of a project is not only required from many funders and journals for publication, it will also be of good help for the researcher throughout the project and beyond.

10:15-12:00 Workshop 1 – Data Management Plans

Bring your laptop and we will guide you through the Data Management Plan support program that will help you create your own plan.

13:15-15:00 Workshop 2 – Working with Human Data

How can we meet the requirements of Open Data, FAIR and share data when we only work with Sensitive Human Data? Is it possible?

SciLifeLab & AAAS/Science Publishing Workshop for Junior Researchers
2025-04-24 08:30 - 15:30 | Birgit Thilander Lecture Hall, Medicinaregatan 3, Göteborg
Are you a junior researcher looking to navigate the scientific publishing landscape with confidence? Want to know what makes a great manuscript and how to optimize your chances of getting published in high-impact journals?

Join us for this highly regarded and rewarding interactive workshop hosted by SciLifeLab in collaboration with AAAS/Science, designed for early career researchers (PhD students and postdocs).

Workshop Leaders

Valda Vinson (Executive Editor, Science Magazine) and Sacha Vignieri (Deputy Editor, Research, Science Magazine) are traveling all the way from the USA to provide you with exclusive insider insights into the entire publishing process – from writing and structuring your paper to peer review and post-publication impact.

Workshop Content

View Curriculum
Morning session (hybrid)

The publishing landscape

Towards reproducibility

Open access and preprints

Authorship

Picking a journal

Preparing your paper

Planning ahead

Structure your paper

Cover Letter

Title/Abstract

Data accessibility

The Publication Process

Process at Science

Review process

Writing a review

Optimizing Impact (author promotion)

Afternoon session (on-site)

This session features an interactive paper tutorial, where participants will engage in in-depth group analysis and discussion of selected preprints—both those nominated by participants and publications chosen by the Editors.

Please note: Pre-workshop preparation is required for all participants.

The selected preprints should fall under one of the following categories:

Cell and Molecular Biology

Genomics, Proteomics and Systems Biology Approaches

Ecology and Environment

Molecular Medicine

Practical Details

The workshop is divided into two sessions:

🔹 Morning Session (Hybrid) – A Zoom link will be provided to online participants one day before the workshop.🔹 Afternoon Session (On-site) – Focused on preprints within life science topics (see Curriculum for details).

Participation Guidelines

🔹 PhD students and postdocs in life sciences will be prioritized for the on-site session.🔹 Pre-workshop preparation is required for all on-site participants.🔹 Everyone is welcome to join online.🔹 On-site participation includes lunch and coffee breaks with the Science Editors.

On-site participation is limited to 40 spots!

Participants for the on-site workshop will be selected after the application deadline based on:✔️ Affiliation (to ensure a fair distribution across research groups).✔️ First come, first served basis.

📅 Deadline for onsite application: March 24, 2025

📅 Deadline for online registration: April 22, 2025

Apply here
