BEGIN:VCALENDAR VERSION:2.0 PRODID:-//SciLifeLab - ECPv6.15.18//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:SciLifeLab X-ORIGINAL-URL:https://www.scilifelab.se X-WR-CALDESC:Events for SciLifeLab REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20250330T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20251026T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20260329T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20261025T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20270328T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20271031T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260127T080000 DTEND;TZID=Europe/Stockholm:20260128T150000 DTSTAMP:20260407T142012 CREATED:20250624T150224Z LAST-MODIFIED:20250925T083137Z UID:10001570-1769500800-1769612400@www.scilifelab.se SUMMARY:Metabolomics in Life Science DESCRIPTION:After the great success of the 2024 Metabolomics in Life Science conference\, the Organizing Committee is thrilled to announce the second edition in 2026!Date: 27-28 January\, 2026Venue: Vävenscenen\, Umeå \n\n\n\n\nUmeå University warmly invites you to Metabolomics in Life Science 2026\, showcasing the latest NMR- and MS-based metabolomics research from Sweden\, the Nordics\, and beyond. The conference brings together researchers from around the world to share knowledge and discuss advances in areas like clinical and precision medicine\, plant metabolomics\, spatial and single-cell metabolomics\, multi-omics\, and computational/AI applications. \n\n\n\nThe event is organized by SciLifeLab platforms in Umeå: Swedish NMR Centre (SNC)\, Swedish Metabolomics Centre (SMC)\, and Computational Analytics Support Platform (CASP). \n\n\n\nThe program includes six keynote speakers from leading institutions\, plus an industry exhibition showcasing the latest technologies and services in metabolomics research. \n\n\n\nRegistration is now open – Register here \n\n\n\nQuestions? Contact: \n\n\n\n\nIlona Dudka – ilona.dudka@umu.se\n\n\n\nKate Bennett – katie.bennett@umu.se\n\n\n\n\nLooking forward to welcoming everyone in Umeå in January 2026! \n\n\n\nRead more\n\n\n\nOrganizersSwedish Metabolomics Centre (SMC) \n\n\n\nNMR Core facility \n\n\n\nComputational Analytics Support Platform (CASP) URL:https://www.scilifelab.se/event/metabolomics-in-life-science/ LOCATION:Väven\, Storgatan 46A\, Umeå\, 90326\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/06/Umea.png ORGANIZER;CN="Swedish Metabolomics Centre (SMC)":MAILTO:annika.johansson01@umu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260126T151500 DTEND;TZID=Europe/Stockholm:20260126T161500 DTSTAMP:20260407T142012 CREATED:20251211T124150Z LAST-MODIFIED:20251211T124151Z UID:10001681-1769440500-1769444100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - How to Terminate Transcription at the Right Place DESCRIPTION:Gene‑Wei Li \n\n\n\nAssociate Professor Massachusetts Institute of Technology (MIT)\, USA \n\n\n\nBio\n\n\n\nGene‑Wei Li is an Associate Professor of Biology at Massachusetts Institute of Technology (MIT) and an Investigator at Howard Hughes Medical Institute (HHMI). He earned a B.S. in Physics from National Tsinghua University (2004) and a Ph.D. in Physics from Harvard University (2010)\, followed by a postdoctoral fellowship at University of California\, San Francisco (UCSF). His research focuses on how bacterial genomes encode quantitative control over protein production — exploring how cells optimize proteome composition through precise regulation of transcription\, translation\, and RNA processing. \n\n\n\nHow to Terminate Transcription at the Right Place \n\n\n\nPrecise transcription termination is essential for defining gene boundaries and achieving proper RNA output. I will discuss two recent advances regarding transcription termination in bacteria. First\, we re-defined the features required for intrinsic terminators: in addition to the canonical hairpin and U-tract\, two conserved sequence motifs are also necessary. This new definition quantitatively explains variations in termination efficiency and accurately pinpoints functional terminators genome-wide. Second\, we showed that many bacteria have evolved purine-rich genes to avoid premature transcription termination\, especially in species with “runaway transcription\,” i.e.\, those uncoupled transcription-translation. This bias imposes strong evolutionary constraints on codon usage and the assimilation of foreign genes. Together\, these principles illuminate the design principles of bacterial gene sequences and how genomes encode the correct endpoints of transcription \n\n\n\n \n\n\n\nHost: Johan Elf johan.elf@icm.uu.se UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-gene-wei-li/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260123T100000 DTEND;TZID=Europe/Stockholm:20260123T110000 DTSTAMP:20260407T142012 CREATED:20251219T093846Z LAST-MODIFIED:20251219T113322Z UID:10001686-1769162400-1769166000@www.scilifelab.se SUMMARY:Genetic code reprogramming for the discovery of macrocycles for therapeutic innovation DESCRIPTION:Hiroaki Suga\, Ph.D.Professor\, Department of Chemistry\, School of Science\, The University of Tokyo \n\n\n\nHiroaki Suga is best known for his work on artificial ribozymes (Flexizyme) and their application in mRNA display (RaPID\, random nonstandard peptide integrated discovery). He is also the founder of the very successful drug discovery company PeptiDream\, Inc. He was awarded the Wolf Prize in Chemistry in 2023. \n\n\n\nHost: David Drew\, SciLifeLab URL:https://www.scilifelab.se/event/genetic-code-reprogramming-for-the-discovery-of-macrocycles-for-therapeutic-innovation/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260123T090000 DTEND;TZID=Europe/Stockholm:20260123T170000 DTSTAMP:20260407T142012 CREATED:20251204T133007Z LAST-MODIFIED:20260119T080732Z UID:10001679-1769158800-1769187600@www.scilifelab.se SUMMARY:Unlocking Precision Health: From Molecular Insights to Clinical Impact in Complex Diseases DESCRIPTION:The 3rd Symposium on Complex Diseases \n\n\n\nJoin us for an exciting day dedicated to advancing precision health and tackling the challenges of complex diseases. This symposium brings together leading researchers\, clinicians\, and industry to explore how molecular insights can transform clinical practice and improve patient outcomes. \n\n\n\nFor information about the symposium in Swedish: Unlocking Precision Health: From Molecular Insights to Clinical Impact in Complex Diseases (Swe). \n\n\n\nConfirmed Speakers:\n\n\n\n\nOskar Frisell\, Karolinska Institutet\n\n\n\nAndrea Ganna\, University of Helsinki\, Finland\n\n\n\nLina Jonsson\, University of Gothenburg\n\n\n\nRichard Landberg\, Chalmers University of Technology\n\n\n\nTuuli Lapalainen\, KTH Royal Institute of Technology\n\n\n\nRuth Loos\, University of Copenhagen\, Denmark\n\n\n\nOlle Melander\, Lund University\n\n\n\nRichard Rosenquist Brandell\, Karolinska Institutet\n\n\n\nPeter Würtz\, Nightingale Health\, Finland\n\n\n\n\nRegistration\n\n\n\nRegister via this form: https://forms.gle/6C7QzrzxwJ9NBPjd8. Registration deadline: 15 January 2026 \n\n\n\nAbstract Submission deadline: 5 January 2026 \n\n\n\nProgram\n\n\n\nProgram symposium complex diseases Jan 23 2026_FINALDownload\n\n\n\nWhy attend?\n\n\n\nExpand your expertise in genomics\, multi-omics\, and precision medicine. \n\n\n\nNetwork with experts and peers across academia\, healthcare\, and industry. \n\n\n\nParticipate in rapid talks\, poster sessions\, and lively discussions. URL:https://www.scilifelab.se/event/unlocking-precision-health-from-molecular-insights-to-clinical-impact-in-complex-diseases/ LOCATION:Operaterassen\, Karl XII:s Torg\, Stockholm\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260120T151500 DTEND;TZID=Europe/Stockholm:20260120T161500 DTSTAMP:20260407T142012 CREATED:20260108T130106Z LAST-MODIFIED:20260113T112254Z UID:10001693-1768922100-1768925700@www.scilifelab.se SUMMARY:Mapping cells at scale: from tissue volumes to community challenges in vEM DESCRIPTION:Speaker: Aubrey WeigelProject Scientist\, CellMap Project TeamHoward Hughes Medical Institute\, Janelia Research Campus \n\n\n\nAbstract\n\n\n\n\n\n\n\nLarge-scale\, high-resolution imaging of subcellular architecture using volume electron microscopy (vEM) unlocks new opportunities for biological discovery – but realizing this potential requires more than just data acquisition. Scalable infrastructure\, robust protocols\, and trained personnel are critical to extract consistent insight from these complex datasets and make them useful to the broader community. The CellMap Project Team represents a coordinated effort to scale vEM-based segmentation across six dimensions: dataset scale\, biological diversity\, organelle classification complexity\, team training\, analytical depth\, and open access. \n\n\n\nThrough modular training programs\, systematic quality control\, and block-wise processing tools\, the project has grown from individual cell volumes to tissue-scale annotation across dozens of organisms and sample types. Annotated datasets are openly shared through OpenOrganelle\, providing the community with immediate access to high-resolution volumes and voxel-level segmentations. To further catalyze progress in automated segmentation\, we launched the CellMap Segmentation Challenge – a large-scale\, open competition featuring expertly annotated training data from over 20 eFIB-SEM datasets and more than 40 unique organelle classes. \n\n\n\nWe describe how workflows and infrastructure evolved to support this scaling effort\, with a focus on designing datasets that are tailored for specific biological insight yet structured for broad reuse. By scaling people\, protocols\, and pipelines in parallel – and committing to open data practices – the CellMap Project Team provides a model for reproducible\, high-resolution cellular mapping at scale. \n\n\n\nregistration\n\n\n\nBiography \n\n\n\nAubrey Weigel is currently a Project Scientist of the CellMap Project Team at HHMI – Janelia Research Campus. The team uses advanced imaging technologies to study the ultrastructure of subcellular organelles under both healthy and pathological conditions. Aubrey’s previous research background is in biophysics\, with an emphasis in microscopy. Her formal training is in physics and engineering. \n\n\n\nDuring her graduate work Aubrey was the co-discoverer of ergodicity breaking in cells along with Diego Krapf\, driving a pivotal shift in the field of diffusion analysis in living systems. Throughout her postdoctoral career under the guidance of Jennifer Lippincott-Schwartz\, she applied her training in physics and microscopy directly to answer biological questions. Here\, Aubrey unraveled the underlying structure of the endoplasmic reticulum and revealed its complex dynamics. She also uncovered the nano-anatomy of early secretory compartments and discovered a new\, dynamic organelle\, responsible for delivering newly synthesized cargo from the endoplasmic reticulum to the Golgi.  \n\n\n\nAubrey’s recent work as the leader of the Cell Organelle Segmentation in Electron Microscopy (COSEM) project includes developing an invaluable tool for cell biology – an analysis pipeline based on deep learning architectures for segmentation – allowing comprehensive reconstruction and analysis of organelles within entire cells imaged by volumetric electron microscopy. CellMap is now building upon this pipeline to generate\, characterize\, and discover how cells look in their native tissue environments – acting as a hub of collaborations that brings together scientists of different disciplines. Aubrey is committed to integrating her multi-disciplinary training into facilitating large-effort\, collaborative\, team projects to take on challenging scientific problems and sharing these resources with the broader scientific community. URL:https://www.scilifelab.se/event/mapping-cells-at-scale-from-tissue-volumes-to-community-challenges-in-vem/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg ORGANIZER;CN="Spotlight Seminar Series":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251218T000000 DTEND;TZID=Europe/Stockholm:20251218T235900 DTSTAMP:20260407T142012 CREATED:20251202T123921Z LAST-MODIFIED:20251202T124514Z UID:10001677-1766016000-1766102340@www.scilifelab.se SUMMARY:SciLifeLab PULSE - information webinar for applicants DESCRIPTION:This webinar (two time options available) gives PULSE applicants an opportunity to receive information on e.g. the matchmaking and application process\, as well as eligibility rules. There will also be time for Q&A:s. Find out more about the SciLifeLab PULSE postdoc program here The 2nd SciLifeLab PULSE Call opened on December 15! \n\n\n\n\n\n\n\n\n\n\n\nWebinar registration\n\n\n\n\n\nWebinar on December 18\, 2025\, at 09:00 am\, UTC+1 \n\n\n\n\n\nRegister here\n\n\n\n\n\n\n\nWebinar on December 18\, 2025\, at 16:00 pm\, UTC+1 \n\n\n\n\n\nRegister here URL:https://www.scilifelab.se/event/scilifelab-pulse-information-webinar-for-applicants/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/12/AdobeStock_519582269-scaled-1.jpeg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251216T151500 DTEND;TZID=Europe/Stockholm:20251216T161500 DTSTAMP:20260407T142012 CREATED:20251215T084843Z LAST-MODIFIED:20251215T084907Z UID:10001682-1765898100-1765901700@www.scilifelab.se SUMMARY:[Spotlight Seminar Series] The innate power of natural killer cells in cancer therapy DESCRIPTION:Professor Karl-Johan Malmberg (M.D. Ph.D) \, Oslo University \n\n\n\nBiography\n\n\n\nProfessor Karl-Johan Malmbergis a Specialist in Hematology with over 25 years of experience in NK cell research and cancer immunotherapy. He is the Director of a Norwegian Research Council Center of Excellence\, The Precision Immunotherapy Alliance (PRIMA) and leads an international team of 20 scientists based in laboratories both at the University of Oslo\, Norway and the Karolinska Institutet\, Sweden. He is also the Scientific Director of the Center for Advanced Cell and Gene Therapy (ACT) at Oslo University Hospital. The group focus on deciphering basic cellular and molecular mechanisms regulating NK cell function and seek to translate insights from these efforts in the design of novel approaches for NK-cell based cancer immunotherapy against cancer. \n\n\n\nRelevant Publications\n\n\n\nThe innate power of natural killer cells in cancer therapy. \n\n\n\nSohlberg E\, Malmberg KJ.Nat Med. 2025 Jun;31(6):1755-1756. doi: 10.1038/s41591-025-03712-9.PMID: 40355615 \n\n\n\nPan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping. \n\n\n\nNetskar H\, Pfefferle A\, Goodridge JP\, Sohlberg E\, Dufva O\, Teichmann SA\, Brownlie D\, Michaëlsson J\, Marquardt N\, Clancy T\, Horowitz A\, Malmberg KJ.Nat Immunol. 2024 Aug;25(8):1445-1459. doi: 10.1038/s41590-024-01884-z. Epub 2024 Jul 2.PMID: 38956379 \n\n\n\n \n\n\n\nHost: Adnane Achour adnane.achour@ki.se URL:https://www.scilifelab.se/event/spotlight-seminar-series-the-innate-power-of-natural-killer-cells-in-cancer-therapy/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251215T151500 DTEND;TZID=Europe/Stockholm:20251215T161500 DTSTAMP:20260407T142012 CREATED:20251120T123638Z LAST-MODIFIED:20251125T132656Z UID:10001670-1765811700-1765815300@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Optogenetic control of gene expression dynamics in single cells DESCRIPTION:Mary Dunlop \n\n\n\nProfessor Boston University\, USA \n\n\n\nBio\n\n\n\nMary Dunlop is a Professor of Biomedical Engineering and Dorf-Ebner Distinguished Faculty Fellow at Boston University. She holds additional affiliations in Bioinformatics and Molecular Biology\, Cell Biology & Biochemistry. She graduated from Princeton University with a B.S.E. in Mechanical and Aerospace Engineering and a minor in Computer Science. She then received her M.S. and Ph.D. in Mechanical Engineering from the California Institute of Technology. In recognition of her outstanding research contributions\, she has received many honors including election as an AIMBE Fellow\, the NSF Transitions Award\, ACS Synthetic Biology Young Investigator Award\, DOE Early Career Award\, and NSF CAREER Award. She is also the recipient of several mentoring and teaching awards\, including Boston University’s Award for Excellence in Mentoring Postdocs and the College of Engineering Teaching Excellence Award. \n\n\n\nOptogenetic control of gene expression dynamics in single cells \n\n\n\nEmerging approaches that integrate optogenetics with feedback control are transforming our ability to precisely manipulate microbial gene expression dynamics. In this talk\, I will present how we harnessed deep neural networks and model predictive control to impose real-time\, cell-specific gene expression patterns in bacteria\, revealing crucial links between dynamic regulation and functional outcomes such as antibiotic resistance. I will also highlight our use of optogenetic tools and information theory to understand how variable expression of a key transcription factor influences downstream stress response genes and impacts bacterial survival under antimicrobial stress. These approaches provide new insights into the significant roles of cellular heterogeneity and dynamic regulation\, advancing our understanding of gene expression and microbial behavior at the single-cell level. \n\n\n\n \n\n\n\nHost: Daniel Jones daniel.jones@icm.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-mary-dunlop/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251211T130000 DTEND;TZID=Europe/Stockholm:20251211T160000 DTSTAMP:20260407T142012 CREATED:20251027T112529Z LAST-MODIFIED:20251211T084725Z UID:10001654-1765458000-1765468800@www.scilifelab.se SUMMARY:Science & SciLifeLab Prize Scientific Symposium 2025 DESCRIPTION:Welcome to the Scientific Symposium where the winners of the 2025 Science & SciLifeLab Prize for Young Scientists will present their research! \n\n\n\nScience\, the American Association for the Advancement of Science (AAAS)\, and SciLifeLab joined forces in 2013\, creating the Science & SciLifeLab Prize for Young Scientists to recognize excellence amongst young researchers from around the world. A global Prize aimed at rewarding scientists at an early stage of their careers. \n\n\n\nThe Prize is awarded in four different categories and the winners will be announced on November 14th \n\n\n\n\nUche Medoh\, Grand Prize Winner in Molecular Medicine\n\n\n\nLiam Lachs\, Category Winner in Ecology and Environment\n\n\n\nNitzan Tal\, Category Winner in Genomics\, Proteomics\, and Systems Biology Approaches\n\n\n\nKing L. Hung\, Category Winner in Cell and Molecular Biology\n\n\n\n\nAll four winners of the Science & SciLifeLab Prize for Young Scientists are invited to Sweden December 8-13 to participate in a unique week filled with events in honor of science. They will have the opportunity to meet with leading scientists in their field of research and create life-long connections to support their careers. \n\n\n\n \n\n\n\nThe symposium will take place at beautiful Grand Hôtel in Stockholm. \n\n\n\nSeats are limited so register today for your chance to meet with the winners and the the AAAS/Science editor team AND our honorary guest\, the Grand Prize Winner from 2024\, Andrija Sente. \n\n\n\nRegistration\n\n\n\nProgram\n\n\n\nScience SciLifeLab Prize SymposiumDownload\n\n\n\nRead more about the Prize\n\n\n\nRead more about the winners URL:https://www.scilifelab.se/event/science-scilifelab-prize-scientific-symposium-2025/ LOCATION:Auditorium Stockholm\, Grand Hôtel\, Södra Blasieholmshamnen 8\, Stockholm\, 10327\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2020/05/prize_2018_puff.jpg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251210T100000 DTEND;TZID=Europe/Stockholm:20251210T120000 DTSTAMP:20260407T142012 CREATED:20251031T080951Z LAST-MODIFIED:20251120T111741Z UID:10001657-1765360800-1765368000@www.scilifelab.se SUMMARY:Teaching and training as "communication": leveraging cognitive and communication theories to strengthen learning DESCRIPTION:Invited speaker: Professor Rochelle E. Tractenberg\, Georgetown University \n\n\n\nSciLifeLab as a Research Infrastructure incorporates people across a variety of technically complex fields. Staff-scientists and researchers often need to communicate about their complex work to people who are not fully familiar with all the details. Swedish universities offer training or support for scientists to help them communicate complex ideas for the public. However\, we don’t often consider that these communication theories and strategies might be equally useful for promoting or strengthening a learning culture across the organization or that such communication strategies are useful in the training and teaching staff-scientists and researchers are involved in. This talk by Professor Tractenberg from Georgetown University will outline two theories – one for communication and one for change management – which have been augmented with cognitive theories so that they can optimize teaching and training and with this strengthen learning. \n\n\n\n\n\n\n\n\n\n \n\n\n\nWelcome to a seminar where Professor Rochelle Tractenberg will present her recent work combining communication with change management strategies. We will learn how we can more efficiently can promote change around complex information – such as encouraging researchers to utilize a new method or tool\, or instructing students about a complex aspect of the field they’re studying. \n\n\n\nFor registrants wishing to participate online\, please indicate this in the registration form. For people attending onsite there will be a light lunch provided after the seminar. \n\n\n\nRegister here\n\n\n\nScientific abstract\n\n\n\nTractenberg’s augmented Diffusion of Innovation (aDOI\, Tractenberg\, 2023) is a theoretical framework for understanding and leveraging the cognitive complexity of messages so as to optimize uptake of the new information by any hearer. aDOI is adapted\, through cognitive theory\, from Rogers’ DOI communication model (1965/2003). A concrete\, stepwise theory of change management (ToCM\, Kotter 2012) originated in business\, and has been widely used across business and leadership programs. This theory has also been augmented with cognitive theory (aToCM\, Tractenberg 2024). Together\, these two revised models provide a strategy for promoting change around complex information – such as encouraging scientists to utilize a new method or tool\, or educating students about a complex aspect of the field they’re studying. Tractenberg’s augmented Diffusion of Innovation and Theory of Change Management make encouraging uptake of new ideas\, or new knowledge\, more consistent with human reasoning. These can support instructors’ adaptation of existing courses to include new information/technology or techniques\, and can also help instructors to learn new evidence-based methods of teaching and assessing. URL:https://www.scilifelab.se/event/teaching-and-training-as-communication-leveraging-cognitive-and-communication-theories-to-strengthen-learning/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="Training Hub":MAILTO:traininghub@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251208T151500 DTEND;TZID=Europe/Stockholm:20251208T161500 DTSTAMP:20260407T142012 CREATED:20251120T122932Z LAST-MODIFIED:20251124T132739Z UID:10001669-1765206900-1765210500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - The origins of locally adaptive loci DESCRIPTION:Gabriela Montejo-Kovacevich \n\n\n\nAssistant Professor SciLifeLab Fellow Uppsala University \n\n\n\n\n\n\n\nBio\n\n\n\nGabriela Montejo-Kovacevich is a SciLifeLab fellow and Assistant Professor that recently established her lab at the Animal Ecology program in the Department of Ecology and Genetics at EBC (Uppsala University). Her group studies mechanisms that promote or constrain local adaptation. By integrating genomics with ecological and natural history approaches\, mainly in insects\, they explore the mode and tempo of evolution in natural populations. \n\n\n\nThe origins of locally adaptive lociHow do organisms evolve to inhabit diverse environments? This seminar explores the mode and tempo of evolution in the wild by studying local adaptation in three insect systems. I will first present work on Heliconius butterflies along a 1500m altitudinal gradient in the Andes\, revealing strong\, repeated selection at high-altitude\, with evidence for adaptive introgression from pre-adapted species. I will then turn to a ‘megapest’ moth (Helicoverpa) that is threatening food security in Brazil through bidirectional adaptive introgression conferring insecticide resistance. Finally\, I will introduce Euphydryas editha\, a Californian butterfly capable of rapid\, heritable shifts in host plant use offering a rare glimpse into ongoing behavioural adaptation to anthropogenic change. Together\, these systems demonstrate how evolutionary forces interact to shape resilience in a rapidly changing world. \n\n\n\nHost: Göran Arnqvist Goran.Arnqvist@ebc.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-gabriela-montejo-kovacevich/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251205T101500 DTEND;TZID=Europe/Stockholm:20251205T110000 DTSTAMP:20260407T142012 CREATED:20251120T134320Z LAST-MODIFIED:20251120T140035Z UID:10001671-1764929700-1764932400@www.scilifelab.se SUMMARY:Discovery and developmentof GRK2-biased beta 2-adrenergic receptor agonists for the treatment of metabolic disorders DESCRIPTION:Presenter: Dr Benjamin Pelcman\, Atrogi AB \n\n\n\nAtrogi AB is biotech company pioneering first-in-class treatments to revolutionize metabolic health. The talk will describe how targeting a novel GRK-biased b2-adrenergic receptor signaling pathway allows for the successful design of compounds useful in the treatment of disorders like type 2 diabetes (T2D)\, obesity and muscular wasting. The approach will be exemplified by the invention\, selection and development of ATR-258\, a b2-AR agonist that was developed for T2D and is about to enter phase 2 clinical trials. During the exploration of the chemical space\, a diverse set of molecules were synthesized\, and their effect on the downstream signaling will be discussed. In addition\, the seminar will illustrate differences between drug development in Big Pharma and small biotech and the challenges of working in an environment with limited resources. \n\n\n\nAfter receiving his Ph.D. in Organic Chemistry at KTH and a post doc session at Dartmouth College\, NH\, USA\, Benjamin joined Astra Pain Control\, first in Södertälje and then in Montreal\, as a medicinal chemist. Benjamin has also held various positions at Pharmacia & Upjohn\, Karo Bio\, Biolipox and Orexo. After having started his own consultancy company\, BeePCo\, he came in contact with Atrogi where he was employed first as a CEO and later as Head of Chemistry and IP. Benjamin is now retired but is still working as a consultant for Atrogi and other small biotechs. URL:https://www.scilifelab.se/event/discovery-and-developmentof-grk2-biased-beta-2-adrenergic-receptor-agonists-for-the-treatment-of-metabolic-disorders/ LOCATION:BMC Room C4:301\, Husargatan 3\, entrance C1\, Uppsala\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251204T090000 DTEND;TZID=Europe/Stockholm:20251204T170000 DTSTAMP:20260407T142012 CREATED:20251006T130957Z LAST-MODIFIED:20251007T070354Z UID:10001632-1764838800-1764867600@www.scilifelab.se SUMMARY:3D Imaging in Health and Disease DESCRIPTION:Characterizing molecular and cellular complexities in 3D is an emerging field allowing to study biology in its true context. \n\n\n\nIn this symposium national and international experts will present developments and applications in 3D imaging aimed to improve health and disease analysis across scales \n\n\n\nPlease register by sending an e-mail to hans.blom@scilifelb.se \n\n\n\n \n\n\n\nProgram 3D symposiumDownload URL:https://www.scilifelab.se/event/3d-imaging-in-health-and-disease/ LOCATION:Nobel Forum\, Nobels väg 1\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="integrated Microscopy Technologies":MAILTO:hblom@kth.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251204T090000 DTEND;TZID=Europe/Stockholm:20251204T103000 DTSTAMP:20260407T142012 CREATED:20250812T104118Z LAST-MODIFIED:20250929T063104Z UID:10001579-1764838800-1764844200@www.scilifelab.se SUMMARY:User meeting for your multi-modal research projects DESCRIPTION:Boost your research — Book a private SciLifeLab planning and feedback session for your multi-modal research projects! \n\n\n\n \n\n\n\nRegister here\n\n\n\nOnce we have received your registration\, you will be sent the link to the online meeting. \n\n\n\nDate: December 4\, 9.00 – 10.30 Registration deadline: November 28 \n\n\n\nMultimodal molecular profiling and novel computational methods are transforming life science research\, but also pose new challenges in study design\, project resource planning and data management. SciLifeLab is a national resource of unique technologies and expertise available to life scientists\, in areas such as biomedicine\, ecology and evolution\, aiming to bring scientists together across traditional boundaries and foster collaborations with industry\, health care\, public research organizations and international partners. \n\n\n\nThe first Thursday of every month at 9.00 (except July and August)\, SciLifeLab offers an opportunity to jointly meet with representatives across the SciLifeLab service platforms\, to get feedback and help to plan\, design\, and refine new or ongoing multimodal research projects. Your project plans are discussed privately and remain confidential\, and information will not be shared outside of the service platforms. Note that for most studies\, follow-up meetings will be needed\, but our aim for these meetings is to provide an easy-access entry point for an overarching planning of multimodal studies. \n\n\n\nFor studies focusing on a single technology only\, please primarily contact our service platforms directly as described at the SciLifeLab homepage. \n\n\n\nTo make the best out of the allotted time\, we ask you to provide some background information about your project\, to help us ensure that the relevant experts are available to discuss your study. URL:https://www.scilifelab.se/event/user-meeting-for-your-multi-modal-research-projects-3/ LOCATION:virtual event CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2025/08/AdobeStock_1081766437-scaled.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251202T130000 DTEND;TZID=Europe/Stockholm:20251202T140000 DTSTAMP:20260407T142012 CREATED:20251103T123419Z LAST-MODIFIED:20251103T125156Z UID:10001658-1764680400-1764684000@www.scilifelab.se SUMMARY:Is high-throughput electrophysiology possible? DESCRIPTION:Register here\n\n\n\n\nOn site seminar – Electrophysiology Infrastructure\n\n\n\nLocation: Jörgen Lehmann\, Academicum\, Medicinaregatan 3 and SciLifeLab Gothenburg \n\n\n\n\nPresenters\n\n\n\n\nFredrik Elinder\, Professor\, Site director SciLifeLab Linköping\, Chemical Biology Consortium Sweden (CBCS)\, and Department of Biomedical and Clinical Sciences (BKV)\, Linköping University \n\n\n\n\n\nNina Ottosson\, Research Coordinator\, Chemical Biology Consortium Sweden (CBCS)\, and Department of Biomedical and Clinical Sciences (BKV)\, Linköping University \n\n\n\n\n\nThe electrophysiology unit at Linköping University\, part of Chemical Biology Consortium Sweden (CBCS) at SciLifeLab\, visits site Gothenburg\, and presents the infrastructure during a seminar. \n\n\n\nDuring the day\, 1-on-1 meetings with the presenters will be possible at The SciLifeLab office\, Medicinaregatan 3. Take the chance to discuss how your research questions can be answered through analyses of ion channels. Request is added in the registration form. \n\n\n\nThe electrophysiology unit\, a recent addition to SciLifeLab’s range of infrastructures\, is equipped with automated patch-clamp instrumentation\, and supports a wide range of electrophysiological studies involving both voltage-gated and ligand-gated ion channels\, including pharmacological screening\, cardiac safety assessments\, and biophysical investigations. \n\n\n\nWELCOME! \n\n\n\nFredrik Elinder and Nina Ottosson\, Electrophysiologists \n\n\n\nJosefine Sandström and Maria Smedh\, SciLifeLab site coordinators Webpage of the CBCS Linköping node.  URL:https://www.scilifelab.se/event/is-high-throughput-electrophysiology-possible-2/ CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2025/06/electrophysiology-visit.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251202T100000 DTEND;TZID=Europe/Stockholm:20251202T113000 DTSTAMP:20260407T142012 CREATED:20251028T115513Z LAST-MODIFIED:20251117T092940Z UID:10001655-1764669600-1764675000@www.scilifelab.se SUMMARY:Introduction to the Module System on Berzelius DESCRIPTION:This training offers a practical introduction to the module system on Berzelius. The session will cover: \n\n\n\n\nhow to find modules on Berzelius\n\n\n\nload/unload modules\n\n\n\nuse modules in interactive or batch modes\n\n\n\ncreate your own module\n\n\n\n\nParticipants will also gain hands-on experience with these commands. By the end of the session\, you will be able to navigate the modules system Berzelius confidently and use them effectively for your research.-on experience with these commands. By the end of the session\, you will be able to navigate Berzelius confidently and use its resources effectively for your research. \n\n\n\nDate: December 2\, 2025Time: 10:00–11:30 \n\n\n\nTarget audience: The online event is open for all current and prospective Berzelius users. Please read the eligibility requirements for accessing Berzelius.Place: Online via Zoom (link provided upon registration) \n\n\n\nregistration\n\n\n\nPreliminary Agenda \n\n\n\nTimeSession TitleSpeaker(s)10:00–11:00Introduction to the Module System on BerzeliusSoumi Chaki11:00–11:30Open Q&A SessionBerzelius Application Expert\n\n\n\nThis event is a collaboration between National Supercomputer Centre (NSC) at Linköping University and SciLifeLab Data Centre. \n\n\n\nFor questions please contact soumi.chaki@liu.se (Soumi Chaki) URL:https://www.scilifelab.se/event/introduction-to-the-module-system-on-berzelius/ LOCATION:Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2025/10/NSC-Berzelius-LiU-2025-3451-Photographer-Magnus-Johansson.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251201T151500 DTEND;TZID=Europe/Stockholm:20251201T161500 DTSTAMP:20260407T142012 CREATED:20251119T104324Z LAST-MODIFIED:20251119T104326Z UID:10001668-1764602100-1764605700@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Genome organisation and patterns of molecular evolution DESCRIPTION:Jennifer James \n\n\n\nAssistant Professor DDLS Fellow \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nDr. Jennifer James did her PhD in population genetics with Adam Eyre-Walker at the University of Sussex. After a postdoctoral position at the University of Cambridge she moved to the US\, where she worked as a postdoctoral researcher with Joanna Masel at the University of Arizona\, which introduced her to the world of proteomics. She next moved to Uppsala and worked as a postdoctoral research fellow with Martin Lascoux prior to becoming a DDLS fellow and starting her own new research group in Molecular Evolution. Her group conducts research on patterns of molecular evolution both at the genome and proteome level\, with a focus on understanding mutational robustness. \n\n\n\n \n\n\n\n \n\n\n\nGenome organisation and patterns of molecular evolution\n\n\n\n \n\n\n\nIn my group\, we try to understand patterns of phenotypic evolution at the proteome level\, and molecular evolution across the genome. Key to this question is understanding how the genome is structured and organised. For example\, how pleiotropic are the effects of genes on average\, and how complex are gene networks? To give one case\, if pleiotropy is universal\, such that all genes affect all traits\, we expect all new mutations to have the same effect on fitness. However\, the extent of pleiotropy in real biological systems remains debated. In this seminar I will discuss our \n\n\n\n \n\n\n\nHost: Siv Andersson siv.andersson@icm.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-jennifer-james/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251128T090000 DTEND;TZID=Europe/Stockholm:20251128T093000 DTSTAMP:20260407T142012 CREATED:20251117T152805Z LAST-MODIFIED:20251127T042951Z UID:10001666-1764320400-1764322200@www.scilifelab.se SUMMARY:Multimodal explorative testing in the ON-OFF ibrutinib trial in CLL DESCRIPTION:Multimodal explorative testing in the ON-OFF ibrutinib trial in CLLRichard Rosenquist Brandell\, Karolinska Institutet & Karolinska University Hospital \n\n\n\nChronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western World and displays substantial variability in clinical course\, ranging from indolent disease requiring no therapy to highly aggressive forms with short survival despite treatment. Although the past decade has seen major advances in drug development\, CLL remains incurable. Targeted therapies\, particularly Bruton’s tyrosine kinase inhibitors (BTKi)\, have become central to CLL management. However\, continuous long-term BTKi administration\, such as with ibrutinib\, is associated with considerable significant side-effects\, including cardiac arrhythmias. Furthermore\, despite its proven efficacy in both treatment-naïve and relapsed/refractory CLL\, resistance to ibrutinib continues to challenge durable disease control. To address these limitations\, we conducted a phase 1b/2 prospective\, single-arm\, multicenter study evaluating controlled treatment cessation as a strategy to preserve tolerability and maintain sensitivity to ibrutinib\, while also improving cost-effectiveness. The study protocol incorporated serial blood sampling prior to treatment initiation and throughout on/off treatment periods. Here\, we leverage this unique longitudinal sample collection to perform multimodal profiling\, including genomic and transcriptomic sequencing as well as proteomics\, to investigate mechanisms of drug response and resistance. We provide an update on the current status of the study and ongoing analyses. \n\n\n\nregistration\n\n\n\nBiography \n\n\n\n\n\n\n\nRichard Rosenquist Brandell is Professor of Clinical Genetics at the Department of Molecular Medicine and Surgery\, Karolinska Institutet\, and Senior Physician in Clinical Genetics at Karolinska University Hospital\, Sweden. Focusing on hematological malignancies and utilizing high-throughput sequencing and other innovative technologies\, his research team has identified novel prognostic and predictive biomarkers that have refined disease classification and significantly improved patient risk-stratification and clinical decision-making. Richard Rosenquist Brandell initiated and led the Clinical Genomics Unit within Science for Life Laboratory (SciLifeLab) in Uppsala (2013-2017) and was platform director for the Clinical Genomics platform (2016-2021) within SciLifeLab\, which includes seven Clinical Genomics units across Sweden. He is currently Director of Genomic Medicine Sweden (GMS)\, a national infrastructure for implementation of precision medicine. Rosenquist Brandell is a member of the Nobel Assembly at Karolinska Institutet. URL:https://www.scilifelab.se/event/multimodal-explorative-testing-in-the-on-off-ibrutinib-trial-in-cll/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="Clinical Talks":MAILTO:precisionmedicine@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251126T150000 DTEND;TZID=Europe/Stockholm:20251126T160000 DTSTAMP:20260407T142012 CREATED:20251118T082253Z LAST-MODIFIED:20251118T110049Z UID:10001665-1764169200-1764172800@www.scilifelab.se SUMMARY:NanoSIMS webinar series: Chemical bio-imaging using ToF-SIMS and OrbiSIMS DESCRIPTION:This month’s Mass Spectrometry Imaging webinar will focus on chemical bio-imaging using ToF-SIMS and OrbiSIMS\, what it is and where it is located\, presented by Prof. David J. Scurr\, the University of Nottingham\, UK. \n\n\n\n \n\n\n\n🕒 Time: 15:00–16:00 (presentation and discussion)☕ Followed by: Informal discussion with the speaker\, 16:00–16:30📍 Format: Zoom \n\n\n\n\nZoom link\n\n\n\n\nMeeting ID: 616 3655 5280Passcode: 499253 \n\n\n\nSpeaker\n\n\n\n\n\nProf. David J. Scurr is a Principal Research Fellow at The University of Nottingham. He has pioneered the application of ToF-SIMS and OrbiSIMS in the field of pharmacy and biology. He obtained a BSc in Materials Science (2002) and PhD focusing upon materials characterisation (2005) at The University of Manchester. David’s research has a focus upon the implantation of novel data processing strategies\, such as molecular formula prediction (MFP) [Edney et al. Anal. Chem. 2022].  \n\n\n\n \n\n\n\n\n\n \n\n\n\n\n\n\n\n\n\n\n\n\n\nHis research highlights include the characterisation of biological samples using ToF-SIMS and OrbiSIMS\, for example\, breakthrough research into the in situ analysis of unlabelled proteins [Kotowska et al. Nature Comms\, 2020] forming the basis of novel research in the development of proteomics / metabolomics\, diseased tissue analysis and biomaterials at The University of Nottingham. Additionally\, David’s research has demonstrated the ability of SIMS to characterise skin tissue and understand permeation mechanisms of xenobiotic chemistries (pharmaceutical\, cosmetic\, agrochemical and antibacterial) within complex tissues such as skin [Starr et al. PNAS\, 2022]. URL:https://www.scilifelab.se/event/chemical-bio-imaging-using-tof-sims-and-orbisims/ CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/11/OrbiSIMS.png ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se LOCATION: END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251125T151500 DTEND;TZID=Europe/Stockholm:20251125T163000 DTSTAMP:20260407T142012 CREATED:20251110T125804Z LAST-MODIFIED:20251112T145847Z UID:10001662-1764083700-1764088200@www.scilifelab.se SUMMARY:[Spotlight Seminar Series] Molecular Mechanisms Underlying the Energy Currents of Life DESCRIPTION:Spotlight seminar series proudly welcomes Professor Vile R. I. Kaila to give a seminar at SciLifeLab Campus Solna. \n\n\n\n\n\n\n\nBiography\n\n\n\nVille R. I. Kaila received his PhD in biochemistry in 2009 from University of Helsinki. After a postdoc at the US National Institutes of Health (NIH)\, he was appointed a professorship at the Technical University of Munich in 2013. In 2019\, Kaila moved with his research group to Stockholm\, where he is currently professor at the Department of Biochemistry and Biophysics at Stockholm University and a Wallenberg Scholar. His research focuses on elucidating mechanistic principles of bioenergetic enzyme complexes by development of integrative computational and experimental approaches. Read more at http://villekaila.com/ \n\n\n\nAbstract\n\n\n\nBiological energy conversion is catalyzed by intricate protein complexes that transduce redox energy into proton currents across a biological membrane\, powering the cellular energy metabolism. Yet\, despite significant advances in recent years\, the molecular principles of these reactions remain poorly understood and pose major scientific challenges. In this talk\, I describe our integrative mechanistic exploration of complex bioenergetic machines\, where we combine multiscale simulations and data-driven methods with biophysical experiments and structural (cryo-EM) studies to derive a molecular understanding of intricate long-range charge transfer reactions in biology on a broad range of timescales and spatial resolutions. I describe our recent work on understanding enzymes catalyzing long-range charge transfer reaction by intrinsic electric field effects. We find that mutations of key residues mediating these allosteric processes lead to perturbed coupling effects\, and development of severe human diseases\, with striking similarities in different biological systems. \n\n\n\n \n\n\n\nHost: Marta Carroni marta.carroni@scilifelab.se URL:https://www.scilifelab.se/event/spotlight-seminar-series-molecular-mechanisms-underlying-the-energy-currents-of-life/ LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251125T110000 DTEND;TZID=Europe/Stockholm:20251125T120000 DTSTAMP:20260407T142012 CREATED:20251023T090757Z LAST-MODIFIED:20251204T093012Z UID:10001643-1764068400-1764072000@www.scilifelab.se SUMMARY:FAIR play: Mastering Metadata to Empower Life Scientists DESCRIPTION:Unlock the potential of your research by mastering meta(data) management in and the FAIR Data Principles—Findable\, Accessible\, Interoperable\, and Reusable. This session offers practical guidance tailored for life scientists\, focusing on best practices to organise and share your data effectively. The talk will focus on how good metadata practices can enhance collaboration\, ensure reproducibility\, and align your work with Open Science principles\, ultimately increasing the impact of your research. \n\n\n\nPresenter: Parul Tewatia\, PhD\, project coordinator (FAIR metadata and semantic technologies)\, SciLifeLab Data Centre \n\n\n\nRecording: https://youtu.be/mc4BOOoLTMASlides: https://doi.org/10.17044/scilifelab.28615511 \n\n\n\nMore information\n\nThis event is part of the SciLifeLab Open Science seminar series\, an event series by the SciLifeLab Data Centre and NBIS joint Data Management team.The goal of the events in this seminar series is to provide interesting interactive seminars around topics related to Research Data Management and Open Science in general\, and to foster discussions around best practices. \n\n\nResearch Data Management (RDM) concerns the organization\, storage\, preservation\, and sharing of data that is collected and analyzed during a research project. Proper planning and management of research data will make project management easier and more efficient while projects are being performed. It also facilitates sharing and allows others to validate as well as reuse the data.Open Science is a set of principles and practices that aim to make scientific research from all fields accessible to everyone for the benefits of scientists and society as a whole. Open science is about making sure not only that scientific knowledge is accessible but also that the production of that knowledge itself is inclusive\, equitable and sustainable. \n\n\nThe events are open to everyone working at or affiliated with a Swedish research institute or university. We welcome all researchers\, educational professionals\, staff\, RDM professionals\, and others with an interest in life sciences\, from all university levels. The events are informal and inclusive\, so feel welcome to join and participate in our interesting discussions! \n\n\nThe events will be recorded and published openly after the seminars on the SciLifeLab YouTube channel. The slides will be made available at our SciLifeLab Data Repository. More information about SciLifeLab Data Centre and NBIS joint Open Science seminar series: https://www.scilifelab.se/data/scilifelab-data-management-seminar-series/ \n\n\nIf you have suggestions for topics or presentations\, please contact us at data-management@scilifelab.seFor more information or inquiries\, please contact us at  data-management@scilifelab.se URL:https://www.scilifelab.se/event/openscience-fair/ CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/02/DC_seminar-series_background1-1.png ORGANIZER;CN="Open Science Seminar Series":MAILTO:data-management@scilifelab.se LOCATION:https://uu-se.zoom.us/j/62780940554?from=addon END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251121T100000 DTEND;TZID=Europe/Stockholm:20251121T110000 DTSTAMP:20260407T142012 CREATED:20251107T112045Z LAST-MODIFIED:20251117T092828Z UID:10001661-1763719200-1763722800@www.scilifelab.se SUMMARY:Rapid traversal of vast chemical space using machine learning-guided docking screens to accelerate drug discovery DESCRIPTION:Speaker: Israel Cabeza de Vaca\, Uppsala university (Jens Carlsson group). \n\n\n\nNBIS and SciLifeLab Data Centre arrange an open SciLifeLab AI Seminar Series aimed at knowledge-sharing about Artificial Intelligence and applications in the Life Science community. The seminar series is open to everyone. The seminar is run over Zoom on the third Friday of the month during academic terms\, typically between 10 and 11 am\, with approx. 45 min presentation and 15 min discussion. \n\n\n\nAbstractThe rapid expansion of make-on-demand chemical libraries now offers access to tens of billions of synthetically accessible molecules\, creating unprecedented opportunities for structure-based drug discovery. However\, screening such ultra-large libraries remains computationally prohibitive\, even with state-of-the-art docking methods.In this presentation\, I will describe a hybrid virtual screening strategy that integrates molecular docking with machine learning to efficiently navigate chemical space at the billion-compound scale. The workflow involves docking approximately one million compounds to a target protein and training a classification model to recognize high-scoring molecules. Using conformal prediction\, the model guides compound selection from multi-billion-scale libraries\, drastically reducing the number of molecules requiring explicit docking.Among several algorithms evaluated\, CatBoost provided the best balance between accuracy and computational efficiency\, enabling large-scale applications. When applied to a 3.5-billion-compound library\, this approach reduced the computational cost of virtual screening by over three orders of magnitude. Experimental validation identified novel ligands for multiple G protein–coupled receptors\, including compounds exhibiting designed multi-target activity.These results demonstrate how combining AI-based prediction with physics-based docking can make ultra-large-scale virtual screening a practical and powerful tool for modern drug discovery. \n\n\n\nContactFor questions\, contact bengt.sennblad@scilifelab.se \n\n\n\nzoom link URL:https://www.scilifelab.se/event/rapid-traversal-of-vast-chemical-space-using-machine-learning-guided-docking-screens-to-accelerate-drug-discovery/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251120T130000 DTEND;TZID=Europe/Stockholm:20251120T153000 DTSTAMP:20260407T142012 CREATED:20251023T130459Z LAST-MODIFIED:20251028T082504Z UID:10001644-1763643600-1763652600@www.scilifelab.se SUMMARY:Powering Proteomics: Technologies\, Insights\, and Clinical Applications DESCRIPTION:Join us for an engaging workshop on proteomics\, exploring cutting-edge approaches in mass spectrometry and affinity-based methods. The event will feature external researchers sharing the latest developments and applications in protein analysis. Participants will gain insights into experimental strategies and see real-world examples highlighting how proteomics advances biomedical research and biomarker discovery. \n\n\n\nRegistration\n\n\n\nRegistration\n\n\n\nYou can join the Zoom meeting via the Confirmation email. \n\n\n\nProgram\n\n\n\nWorkshop on proteomicsDownload\n\n\n\n13:00-13:05 Welcome \n\n\n\n13:05-13:30 “Using mass spectrometry to characterize the airway proteome and treatment responses in cystic fibrosis”. \n\n\n\nPresenter: Lisa Påhlman\, Lund University \n\n\n\nHost: Anahita Bakochi\, Clinical Proteomics\, Lund University \n\n\n\n13:30-13:55 “Low Cell Proteomics resolves oncogenic molecular mechanisms in rare cell types” \n\n\n\nPresenter: Pedro Moura\, Karolinska Institute \n\n\n\nHost: Henrik Johansson\, Global Proteomics & proteogenomics\, Karolinska Institute \n\n\n\n13:55-14:20 “Applications of Proteomics in Steatotic Liver Disease” \n\n\n\nPresenter: Tanmoy Dutta\, Gothenburg University \n\n\n\nHost: Carina Sihlbom Wallem\, Glycoproteomics & MS Proteomics\, Gothenburg University \n\n\n\n14:20-14:45 “Shared and specific blood biomarkers for multimorbidity” \n\n\n\nPresenter: Davide Liborio Vetrano\, Karolinska Institute \n\n\n\nHost: Claudia Fredolini\, Affinity Proteomics-Stockholm\, Royal Institute of Technology-KTH \n\n\n\n14:45-15:10 “The circulating blood proteome of childhood acute leukemia” \n\n\n\nPresenter Jessica Nordlund\, Uppsala University \n\n\n\nHost: Mikael Åberg\, Affinity Proteomics Uppsala\, Uppsala University \n\n\n\n15:10:15:30 Questions and Final Remarks URL:https://www.scilifelab.se/event/powering-proteomics-technologies-insights-and-clinical-applications/ CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2025/10/PCF.11-scaled.jpg LOCATION: END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251117T151500 DTEND;TZID=Europe/Stockholm:20251117T161500 DTSTAMP:20260407T142012 CREATED:20251006T081235Z LAST-MODIFIED:20251107T122041Z UID:10001630-1763392500-1763396100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Coagulation: Cancer's new best friend DESCRIPTION:Gareth Owen \n\n\n\nProfessor Pontificia Universidad Católica de Chile\, Chile \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nDr. Gareth Owen is currently visiting Professor in the lab of Dr Masood Kamali-Moghaddam\, Department of Immunology\, Genetics and Pathology\, Uppsala University. He is a full professor in the Faculty of Biological Sciences and Faculty of Medicine at the Pontificia Universidad Catolica de Chile. Dr Owen did his BSc at King’s College London and has a PhD from the Royal Postgraduate Medical School\, Hammersmith Hospital\, London UK (Imperial College London).  This was followed by a post-doctoral fellowships at the University of Colorado USA\, and the Institute of Cancer Research (ICR-UK). Dr Owen is a PI in the Millennium Institute on Immunology and Immunotherapy Chile\, and Board member of the Chilean National Cancer Forum. \n\n\n\n \n\n\n\nCoagulation: Cancer’s new best friend\n\n\n\nCoagulation is linked to cancer progression\, with many patients exhibiting chronic hypercoagulability. Anticoagulant therapy has been associated with improved outcomes. Beyond hemostasis\, the coagulation system can drive inflammation and metastasis\, though the mechanisms remain unclear. Herein\, we demonstrate that elevated levels of activated coagulation factor X (FXa) increase lung metastasis and that FXa promotes an immunosuppressive tumor microenvironment. Using a murine model of melanoma and in vitro assays\, we found that FXa increased infiltration of regulatory T cells and Th17 cells\, and upregulated PD-1 and CTLA-4 expression on CD4+ and CD8+ T cells. Co-treatment with the anti-FXa anticoagulant dalteparin abrogated these effects. Mechanistically\, FXa in vitro suppressed macrophage M1 and Th1 differentiation through the Protease-Activated Receptor-1 (PAR1). The clinically approved PAR1 inhibitor Vorapaxar blocked FXa-induced tumor progression in vivo. These findings identify FXa or PAR1 inhibition as therapeutic strategies in cancer therapy. \n\n\n\n \n\n\n\nHost: Masood Kamali-Moghaddam masood.kamali@igp.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-gareth-owen/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251117T120000 DTEND;TZID=Europe/Stockholm:20251118T090000 DTSTAMP:20260407T142012 CREATED:20250909T084453Z LAST-MODIFIED:20250909T105634Z UID:10001609-1763380800-1763456400@www.scilifelab.se SUMMARY:SwedNMR Meeting: Unravelling BioSolids mysteries by novel NMR approaches DESCRIPTION:Join us on the 17th and 18th of November\, the SwedNMR and its Umeå node will host a meeting were the current achievements will be highlighted and there will be a discussion in future directions in method development and new application areas \n\n\n\n\n\n\n\nSwedNMR offers state-of-the-art NMR infrastructure and expertise to study a wide range of biosolids with atomic-level insight\, including crystalline materials\, drugs\, biomembranes\, protein aggregates\, as well as plant and medical biopsies. SwedNMR via its Umeå node is the first word-wide to offer both ultra-fast solid-state MAS NMR and CryoMAS-NMR solid-state providing a new dimension in structural information and sensitivity for bioSolids. Together with the DNP facility at the NMR Centre in Gothenburg\, SwedNMR provides world-wide unique structural and dynamic insights into complex biological solids and tiny intact biospecimens. \n\n\n\n\nRegistration \n\n\n\n\nRegistration\n\n\n\n\nSign up for the SwedNMR Meeting:  Unravelling BioSolids mysteries by novel NMR approaches\, a two day meeting starting on Monday the 17th of November at 12 pm \n\n\n\nIn the registration you can find more information about the program \n\n\n\nIf you have any further questions you can contact: \n\n\n\nIlona Dudka\, ilona.dudka@umu.se \n\n\n\nGerhard Gröbner\, gerhard.grobner@umu.se  \n\n\n\nTobias Sparrman\, tobias.sparrman@umu.se URL:https://www.scilifelab.se/event/swednmr-meeting-unravelling-biosolids-mysteries-by-novel-nmr-approaches/ LOCATION:Stora Fokusrummet\, KBC\, Linnaeus väg 6\, Umeå\, 90736\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2025/09/KEMI-9788-241126-MPN-scaled.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251113T133000 DTEND;TZID=Europe/Stockholm:20251113T160000 DTSTAMP:20260407T142012 CREATED:20250903T073116Z LAST-MODIFIED:20251105T121833Z UID:10001595-1763040600-1763049600@www.scilifelab.se SUMMARY:DDLS Annual Conference 2025 workshops DESCRIPTION:During the second day of the  DDLS Annual Conference 2025 held at Uppsala Kongress och Konsert (UKK) participants will have an opportunity to attend one of the workshops. The workshops are directed at researchers in data-driven life science in all career stages. \n\n\n\nPlease note that each workshop has a limited number of seats\, on the first come first served basis. Those registered after the limit is reached will be placed on the waiting list. The workshops will take place in various rooms of the main venue of the conference –UKK All workshops start at 13:30 but end at various times. Coffee/tea and fika will be served during the workshops. \n\n\n\nFeel free to email datacentre@scilifelab.se with any questions about workshop 1 and 2 and traininghub@scilifelab.se for workshop 3. \n\n\n\nWorkshops\n\n\n\nWorkshop 1. Automating life science & biomedical tasks with LLMs and beyond: practical guide\n\n\n\nHeld by: Ola Spjuth (UU\, SciLifeLab AI Lead) and AI data engineers Mahbub Ul Alam and Johan Alfredéen at SciLifeLab Data Centre \n\n\n\nWhere and when: November 13\, 2025 at 13:30-16:00\, room K1 (36 seats) UKK \n\n\n\n\nRegistration\n\n\n\n\nDescription:  We will explore how artificial intelligence (AI) can help make your research more productive. You will see how AI agents can help youcreate new\, testable ideas. We will introduce modern agentic AI tools that can automatically handle many research tasks. These tools use powerful large language models (LLMs) to plan and perform complex jobs. You will learn how to apply them using several available cloudplatforms and open-source tools. The main goal is to show you how to use AI to speed up your work and discover new research questions. \n\n\n\nWorkshop participants can then choose from a number of hands-on exercises that they can complete on their own laptops. We will be available to help and answer questions.    \n\n\n\nWorkshop 2. Open Source Software for Research – Sharing Code and Software the Right Way\n\n\n\nHeld by: Chris Erdmann (Head of Open Science\, SciLifeLab) and coordinators Alma Nilsson\, Suné Joubert and Parul Tewatia SciLifeLab Data Centre \n\n\n\nWhere and when: November 13\, 2025 at 13:30-16:00\, room K2 (20 seats) UKK \n\n\n\n\nRegistration\n\n\n\n\nDescription: Research depends on software\, but without open and FAIR practices\, reproducibility and reuse are limited. Open-source software means code that is not only available but also licensed for free use\, modification\, and sharing. This workshop provides an overview of open science policy related to software\, and introduces the Open Science Software Checklist \, showing how to apply it to make research code adhere to open science policies and guidelines. Speaker at the workshop include Malin Sandström from the Swedish Research Council (Vetenskapsrådet) and researchers from the SciLifeLab research community\, as well as coordinators and data stewards from SciLifeLab Data Centre. \n\n\n\nParticipants should bring their own laptop and have a GitHub account. Having Visual Studio Code installed and connected to one’s GitHub is helpful but not required. \n\n\n\nWorkshop 3. Development of a Mastery Rubric for Data Driven Life Scientists\n\n\n\nHeld by: Jill Jaworski\, SciLifeLab Training Hub \n\n\n\nWhere and when: November 13\, 2025 at 13:30-16:00\, room K3+K4 (90 seats) UKK \n\n\n\n\nRegistration\n\n\n\n\nDescription: What is a data-driven life scientist? What knowledge\, skills and abilities do these individuals have and what core competencies do they share within their respective expertise-areas? What distinct characteristics set them apart from other life-scientists? \n\n\n\nIn this interactive workshop\, through facilitated discussions and collaborative exercises\, we will come to a shared understanding of what is required in this profession. We will create a Rubric that outlines the different knowledge\, skill and ability areas of data-driven life scientists and map these competencies against beginner\, intermediate and mastery levels. \n\n\n\nIn this way\, we will help define the scope of data-driven life scientists and demonstrate what is needed for them to progress along learning paths from beginners to masters in their subject areas\, thereby helping them understand how and where they can develop professionally. Amid quickly changing scientific landscapes\, complex and pressing real-world issues\, and growing mistrust in science\, it is important to create a shared framework for what we mean when we describe data-driven life scientists\, which will help bring credibility to the profession\, trust\, and clear guidance on how to professionally develop. \n\n\n\nParticipants will need to bring a laptop or tablet to this workshop to be able to fully participate. URL:https://www.scilifelab.se/event/ddls-annual-conference-2025-workshops/ LOCATION:Uppsala Konsert & Kongress\, Vaksala torg 1\, Uppsala\, 75331\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Data Centre":MAILTO:datacentre@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251112T113000 DTEND;TZID=Europe/Stockholm:20251113T133000 DTSTAMP:20260407T142012 CREATED:20250320T121329Z LAST-MODIFIED:20251112T164228Z UID:10001509-1762947000-1763040600@www.scilifelab.se SUMMARY:DDLS Annual Conference DESCRIPTION:We have reached full capacityWe are currently at full capacity with a waiting list. If you are no longer able to attend\, please cancel your registration as soon as possible. This will allow us to accommodate others on the waiting list and ensure a smooth experience for all attendees. The Program in Hall B will be live-broadcast to SciLifeLab YouTube Talks & Training channel. \n\n\n\n\n\n\n\n\nLive Stream\n\n\n\nLive Stream – November 13\n\n\n\n\n\nLive Stream – November 12\n\n\n\n\n\n\n\n\n\nThe Data-Driven Life Science (DDLS) program\, funded by the Knut and Alice Wallenberg Foundation (KAW)\, warmly welcomes you to the fourth DDLS Annual Conference\, taking place November 12–13\, 2025\, at Uppsala Konsert & Kongress (UKK). \n\n\n\nTarget Group: Anyone interested in data-driven life science is welcome to attend the Conference. You don´t need to be part of the SciLifeLab & Wallenberg National Program for Data-Driven Life Science\, even though the conference focuses on achievements and highlights program activities. \n\n\n\nThis two-day\, in-person event will highlight DDLS research and activities\, showcase new technologies and services available to researchers across Sweden\, and provide a forum for knowledge exchange and collaboration. Participants will have the opportunity to: \n\n\n\n\nShare and discuss research findings\n\n\n\nExplore ideas and insights across disciplines\n\n\n\nBuild networks for collaboration and career development\n\n\n\nGain perspectives beyond their own fields of expertise\n\n\n\n\nThe conference begins with a light lunch and registration on November 12 (11:30–12:30) and concludes with a networking lunch on November 13 (12:30–13:30). \n\n\n\nYouTube live-broadcast\n\n\n\nYouTube broadcast: The Program from Hall B will be live-broadcast on the YouTube SciLifeLab Talks & Training channel. Some speakers may share unpublished data that will be excluded from the live broadcast. You will find a YouTube embedded video player here on the event date. \n\n\n\nHosts & Moderators\n\n\n\nThe DDLS & SciLifeLab Director\, Jan Ellenberg\, will open the 2-day Conference. The DDLS Co-Directors\, Erik Kristansson (Chalmers) and Carolina Wählby (Uppsala University)\, will moderate and guide you through the Program. \n\n\n\nConfirmed speakers\n\n\n\nSpeaker Abstracts_DDLS Annual Conference 2025_v1Download\n\n\n\nInvited speakers\n\n\n\nAnna Kreshuk\, EMBL\nTitle: Deep Learning for MicroscopyAffiliation: EMBL\, HeidelbergBio: Anna Kreshuk is a group leader and a Senior Scientist in the Cell Biology and Biophysics Unit at the European Molecular Biology Laboratory (EMBL) in Heidelberg\, Germany. She received a PhD in Computer Science from Heidelberg University in 2012. Following this\, she worked as a PostDoc in the Heidelberg Collaboratory for Image Processing (HCI). She joined EMBL in July 2018\, where her research group develops novel computer vision methods for the analysis of microscopy images. Beyond method development\, she is also committed to the democratisation of machine learning for the life science community\, contributing open source tools such as ilastik and PlantSeg. She is an ELLIS scholar and a scientific co-coordinator of the Horizon Europe project AI4Life.Abstract: \n\n\n\n\nDaniel Tamarit\, Utrecht University\, the Netherlands\nTitle: The archaeal evolutionary origins of the eukaryotic cell \n\n\n\nAffiliation: Utrecht University\, the Netherlands \n\n\n\nBio: Daniel Tamarit is an Assistant professor at the Theoretical Biology and Bioinformatics (TBB) group\, specialized in comparative and evolutionary genomics. He obtained his PhD at Uppsala University by studying the evolution of host-associated bacteria\, and performed postdoctoral research at Wageningen University on major evolutionary transitions such as the origin of eukaryotes. Currently\, his team uses evolutionary genomics to investigate fundamental questions in archaeal and bacterial biology\, such as (i) what are the principles governing bacterial and archaeal genome architecture\, (ii) what can the genomes of novel microbial lineages tell us about basic evolutionary processes\, and (iii) what is the shape of the tree of life.  \n\n\n\nAbstract: The origin of eukaryotic cells was one of the most impactful transitions in evolution\, setting the basis for the emergence of multicellular organisms such as animals\, plants and fungi. Recent advances in genome-resolved metagenomics and phylogenomics have placed Asgard archaea at the heart of this transition\, revealing that eukaryotes originated from within this group. Expanded genomic sampling and robust evolutionary modeling identify a lineage of Heimdallarchaeia\, the Hodarchaeales\, as the closest known relatives of eukaryotes. Reconstructions of ancestral gene repertoires\, structure-based homology searches\, and targeted experiments suggest that the archaeal progenitor of eukaryotes already possessed an enriched set of genes involved in cytoskeletal dynamics\, membrane trafficking\, and other functions that contribute to cellular complexity. This talk will showcase how integrating computational approaches is transforming our understanding of early cellular evolution and revealing the deep archaeal roots of eukaryotic life. \n\n\n\n\nIngemar André\, Lund University\nTitle: Discovering patterns in the codon sequences of proteinsAffiliation: Center for Molecular Protein Science\, Lund UniversityBio: Prof. André has a PhD in Biophysical Chemistry from Lund University. He joined the University of Washington for postdoctoral work before returning to Lund University to start his research group in 2009. He studies protein self-assembly to understand the mechanism behind the formation of large assemblies using experimental and computational methods. Large assemblies are also designed using computational protein design methods and artificial intelligence. His group also works on the design of conformational changes in proteins. Another direction is the study of codon adaptation in organisms and its effect on co-translational folding. Questions related to how protein structure has evolved are also addressed in research by the group using computational and experimental methods.Abstract: The genetic code defines how amino acid sequences are encoded in mRNA. Due to redundancy\, this encoding is not unique\, with up to six different codons specifying the same amino acid. Historically\, synonymous mutations\, changes between codons for the same amino acid\, have been referred to as “silent.” However\, it is now clear that codon choice can have significant functional consequences. \n\n\n\nWe investigated the effect of synonymous codons on protein folding efficiency in E. coli using a high-throughput experimental assay. Our results reveal a link between protein topology and the proportion of nascent proteins that emerge from the ribosome correctly folded\, showing that even single synonymous substitutions can strongly influence co-translational protein folding. \n\n\n\nComplementary bioinformatic analyses establish a relationship between codon usage and protein secondary structure. Furthermore\, by training a large language model\, we developed a predictive framework that identifies positions of rare codons within coding sequences\, uncovers patterns explaining codon choice along the sequence\, and highlights mRNA stability as an important determinant of codon usage. \n\n\n\n\nJoakim Jaldén\, KTH\nTitle: Restless bandits and self-driving microscopesAffiliation: KTH Royal Institute of TechnologyBio: Joakim Jaldén has a M.Sc. in electrical engineering and a Ph.D. in telecommunications from the KTH. Since his employment as a tenure-track faculty at KTH in 2009\, he has increasingly devoted the group’s research efforts towards data analysis challenges in life science applications. Highlights include: The development of data association algorithms for single-cell tracking in time-lapse microscopy\, in collaboration with the Blau lab at Stanford; Mathematical models and algorithms for cytokine movement and antibody interaction in immunoassay\, which laid the foundation for patented technology behind the Mabtech AB analysis instruments for ELISpot and FluoroSpot\, and most recently\, multiplex assays; Algorithms and AI for long-read DNA basecalling from nanopore data\, in collaboration with SciLifeLab. He has been a full professor at KTH since 2017\, where he is now also deeply engaged in education.Abstract: The talk will focus on one result stemming from a first round of joint WASP-DDLS projects. The proposal envisioned the use of reinforcement learning as a tool to capture images of rare cell states in the context of automated microscopy. It will cover\, at a conceptual level\, the mathematical modeling decisions made to arrive at principled automation rules regarding what field of view to image and for how long\, ending with empirical illustrations of the practically realizable gains. \n\n\n\n\nMark Ravinet\, University of Oslo\, Norway\nTitle: The evolutionary history of a commensal species: lessons from adapting to the AnthropoceneAffiliation: Centre for Ecological and Evolutionary Synthesis\, University of OsloBio: Mark is an evolutionary biologist interested in understanding speciation and adaptation using a wide range of ecological and genomic techinques. He completed his PhD on local adaptation and speciation in three-spined sticklebacks at Queen’s University Belfast. Following that he was a JSPS Postdoctoral Fellow at the National Institute of Genetics\, Japan\, where he worked on the genomics of speciation in marine sticklebacks. He continued his work on the genomics of speciation and hybridisation\, this time on Passer sparrows\, at the University of Oslo as a Marie Curie fellow. It was here that his interest in understanding how human activity has shaped the evolution of other species began. He also has a strong interest in teaching genomics and bioinformatics to those beginning in the field. He has written several well-known resources and is co-author on the textbook Evolutionary Genetics: Concepts\, Analysis and Practice. He is now an Associate Professor at the University of Oslo and his primary research focus is on using Passer sparrows as a model system for understanding how human activity might have driven adaptation\, hybridisation and even potentially speciation in these charismatic little birds.Abstract: Human activity has altered the evolutionary trajectories and ecological circumstances of nearly every species on Earth. Commensal species are an extreme example to adaptation to anthropogenic niches\, benefitting from a close association with human activity. What can the evolution of a commensal life history tell us about how species adapt to environmental change driven by humans?House sparrows (Passer domesticus) are a hugely successful human-commensal species\, occurring on nearly every continent\, largely due to human introductions. Despite its close association human society\, surprisingly little is known about the evolutionary history of this species\, how it has evolved to fit a tight anthropogenic niche and the evolutionary consequences of its rapid global spread. Our work has focused on addressing this.With resequencing data from over 1200 Passer sparrows\, we first reconstructed the evolutionary history of the house sparrow. Our results suggest the species likely adapted to a human niche\, potentially more than once\, in Central Asia during the last 10\,000 years. We used phenotypic data including micro-CT 3D scanning to compare skull morphology between human commensal and wild sparrow populations. We identified clear divergence in skull morphology\, beak shape and an increased brain size in the commensal house sparrow populations. A major signature selective sweep in the house sparrow genome encompasses two major candidate genes; COL11A1 – which regulates craniofacial and skull development and AMY2A which is linked to adaptation to high-starch diets in humans and dogs. Functional analysis of COL11A1 confirms its role in skull development and we show evidence of copy number variation at AMY2A.Our next aim was to investigate the more recent global spread of the species. Native to Eurasia\, the house sparrow was introduced to the Americas\, Australasia and Sub-Saharan Africa in the 19th and 20th centuries. Using resequenced genome data from across this range\, we have reconstructed the population genomic signatures of these introductions. Our findings point to introductions from two divergent lineages of house sparrow to different parts of the world as well as the rapid evolution of genetic differentiation among introduced populations. We further investigated adaptation to climatic variation across the introduced ranges of the species in North America and Australia. We identify several candidate genes linked to growth\, thermoregulation and thermal tolerance\, suggesting introduced populations have adapted to new environmental conditions in less than 150 generations.Our work identifies phenotypes and genes involved in rapid adaptation in parallel to anthropogenic change across the native and introduced range of the house sparrow. With a global distribution spanning a wide range of climatic conditions and a close association with human society\, we suggest the house sparrow is an ideal model species for understanding adaptation in the Anthropocene. \n\n\n\n\nNicolai Birkbak\, Aarhus University\, Denmark\nTitle: T cell receptor diversity and immune health as a prognostic cancer biomarker \n\n\n\nAffiliation: Department of Clinical Medicine\, Aarhus University\, Denmark \n\n\n\nBio: Nicolai Birkbak is Professor of Cancer Evolution and Bioinformatics at Aarhus University and Aarhus University Hospital\, Denmark\, where he leads an independent research group. His research focuses on the bioinformatic analysis of high-dimensional data to understand how the immune system interacts with cancer. By integrating genomic\, transcriptomic\, single-cell\, and spatial data with medical imaging and liquid biopsy analyses\, including circulating tumor DNA and T-cell receptor sequencing\, his group develops holistic biomarkers that capture both tumor biology and host immune responses. \n\n\n\nNicolai trained in bioinformatics at the Technical University of Denmark and completed postdoctoral research at the Dana-Farber Cancer Institute and the Francis Crick Institute. At the Crick\, he contributed to the TRACERx lung cancer evolution project\, advancing understanding of how tumors evolve and evade immune surveillance. His work has also helped identify biomarkers of sensitivity to PARP inhibitors and elucidate mechanisms linking tumor evolution\, immune modulation\, and metastatic progression. \n\n\n\nThe overarching aim of his research is to translate these insights into precision medicine – enabling earlier detection\, improved prediction of treatment response\, and ultimately better outcomes for cancer patients. \n\n\n\nAbstract: The adaptive immune system not only protects us against pathogens but also plays a crucial role in defending against cancer. Among its key components\, T cells serve as central effectors in the endogenous anti-cancer response. Yet\, the clinical significance of their quantity\, diversity\, and dynamics remains insufficiently understood. \n\n\n\nWe investigated the prognostic value of the T cell receptor (TCR) repertoire in patients with bladder cancer. In advanced-stage disease\, we found that low pre-treatment peripheral TCR diversity was associated with poorer overall survival\, particularly when combined with low circulating T cell fractions. These low-diversity repertoires were dominated by hyperexpanded clones that persisted throughout treatment and were frequently directed against chronic viral infections such as cytomegalovirus. Longitudinal analyses further revealed treatment-associated declines in TCR diversity\, suggesting adverse effects on systemic immune health. \n\n\n\nTogether\, these findings highlight that immune health biomarkers such as TCR diversity may provide new opportunities for precision medicine approaches aimed at improving cancer treatment outcomes. \n\n\n\n \n\n\n\n\nVerónica Rendo\, Uppsala University\nTitle: From tumor maps to new therapies for pediatric brain cancer \n\n\n\nAffiliation: Department of Immunology\, Genetics and Pathology; Uppsala University \n\n\n\nBio: Veronica studied Biology at Simon Bolivar University in Venezuela\, and in 2013 moved to Sweden to pursue a PhD at Uppsala University. During this time\, she worked under the mentorship of Prof. Tobias Sjöblom and studied how genomic losses in cancer could be exploited for therapy. In 2019\, she moved to Boston (USA) to pursue a postdoc in Dr. Rameen Beroukhim’s lab at Dana-Farber Cancer Institute\, affiliated with Harvard Medical School and the Broad Institute of MIT and Harvard. Here\, Veronica focused on studying mechanisms of response and resistance associated with p53 reactivation in malignant brain tumors. She additionally continued her work on aneuploidy\, describing a new class of therapeutic targets as ‘toxic genes’ – genes whose high-levels of expression are detrimental to cancer cell fitness. In 2025\, Veronica became a Group Leader in Neuro-Oncology at the Department of Immunology\, Genetics and Pathology at Uppsala University.  Her lab investigates the genetic and adaptive mechanisms driving brain tumor evolution and therapy resistance\, with the goal of identifying new treatment targets. \n\n\n\nAbstract: In Sweden\, cancer remains the leading cause of disease-related death among children\, with brain tumors representing the most lethal subtype due to their limited treatment options and high relapse rates. One rare and aggressive subtype is atypical teratoid/rhabdoid tumors (AT/RT)\, an embryonal brain tumor which affects infants of under 2 years of age. The low incidence of AT/RT has hindered the establishment of a universal standard of care. Because these tumors primarily affect infants under two years of age\, treatment is largely restricted to intensive chemotherapy regimens designed to avoid the harmful effects of radiation therapy. However\, these high-dose regimens often yield only partial responses\, underscoring the urgent need to elucidate mechanisms of chemoresistance and to identify novel therapeutic strategies. We aim to uncover the transcriptional cell states and genetic vulnerabilities associated with chemotherapy-persistent AT/RT\, thereby revealing new targets that can enhance the efficacy of frontline treatments. To this end\, we first employ cellular barcoding to track cancer cell populations at single-cell resolution before and after exposure to individual chemotherapeutic agents used in clinical AT/RT protocols. This approach enables comparison of treatment regimens and identification of overlapping mechanisms of resistance. To further dissect these mechanisms\, we leverage CRISPR sensitizer screens to define targetable genes that potentiate chemotherapy response when depleted. Through our integrated transcriptomic and functional genomic analyses\, we ultimately aim to uncover novel therapeutic targets in chemotherapy-persistent AT/RT cells and accelerate the development of more effective treatment strategies. \n\n\n\n\n \n\n\n\n\nJenny Frössling\, Swedish Veterinary Agency\n\n\n\nKarl Ståhl\, Swedish Veterinary Agency\n\n\n\nErika Chenais\, Swedish Veterinary Agency\n\n\n\nStefan Widgren\, Swedish Veterinary Agency\n\n\n\nHyeyoung Kim\, Swedish Veterinary Agency\n\n\n\nAngela Fuentes Pardo\, SciLifeLab Data Centre with Henrik Lantz\, NBIS.\n\n\n\n\nDDLS Fellows\n\n\n\nAndrea Fossati\, KI\nTitel: Mapping infection at proteome scale: Toward mechanistic design of phage-based antimicrobialsAffiliation: Karolinska InstitutetAbstract: The rise of antimicrobial resistance (AMR) is outpacing the discovery of new antibiotics\, creating an urgent need for alternative strategies. Bacteriophages (phages) offer a promising route to targeted antimicrobials\, but their rational use is hindered by limited understanding of how they reprogram bacterial cells during infection. Our work addresses this by systematically mapping host–phage protein–protein interactions (PPIs) to uncover how viral proteins hijack essential bacterial complexes and redirect cellular physiology. Using next-generation interaction proteomics based on co-fractionation mass spectrometry (SEC-MS)\, we generated the first temporally resolved interactome of mycobacteriophage-infected cells. This approach captures native phage and host complexes without genetic tagging\, enabling functional inference of phage proteins directly from their physical context. We identify hundreds of infection-specific assemblies\, including viral inhibitors of essential bacterial machineries such as RNA polymerase and ribosomes. Structural modeling and comparative network analysis reveal conserved interface motifs and divergent strategies of complex remodeling across phage families. Integration of these data with CRISPRi perturbation and antibiotic susceptibility profiling provides a quantitative framework to predict infection outcomes and phage engineering. \n\n\n\n\nAvlant Nilsson\, KI\nTitle: Towards an interpretable deep learning model of cancerAffiliation: Karolinska InstitutetBio: Avlant Nilsson is a computational biologist and assistant professor in precision medicine at the department of Cell and Molecular Biology at Karolinska Institutet\, Stockholm. He holds a MSc (2009-2014)\, and a PhD (2014-2019) degree in biological engineering from Chalmers University of Technology\, where his thesis focused on the metabolism of growing cells\, including liver cancer.In his postdoctoral work at Massachusetts Institute of Technology (2019-2023)\, he developed artificial neural network models to simulate signal transduction in immune cells.His lab at SciLifeLab is developing techniques to simulate cellular processes in cancer\, aiming at identifying effective drug combinations\, predicting resistance mechanisms\, and understanding cell-cell interactions in the tumor microenvironment.Abstract: Deep learning offers new possibilities for understanding cancer using high throughput data. However\, it can be challenging to translate predictive models into causal description of cellular responses. Our lab develops biologically informed neural networks that integrate omics data with prior knowledge of signaling\, gene regulation\, and metabolism. By constraining the models to only include physical molecular interactions\, we are developing interpretable models for computer-aided design of personalized cancer medicine. With this approach we aim to answer questions such as why the same mutation yields different effects across cell types\, unexpected signaling outcomes of drugs\, and how genetic alterations may drive metabolic strategies. \n\n\n\n\nKelly Swarts\, SLU Umeå\nTitle: Climate adaptation in natural forest treesAffiliation: Umeå Plant Sciences Centre\, Swedish Agricultural UniversityAbstract: Conifers are ecologically dominant and economically important\, but are succumbing to drought\, disease\, early-budding and other challenges globally because the climate has changed so that mature trees are no longer adapted to their environment. If we could predict how individual tree genotypes would respond to different environments\, we could — given environmental predictions — plant the right tree in the right space. Standard agronomic approaches are effective but are less suitable for trees with long generation times and huge genetic diversity. We propose a system for quickly estimating adaptive responses for any forest tree. The key is tree increment core samples\, which simultaneously provide DNA for genotyping and annual growth measurements\, estimated from growth rings. For each genotype\, we thus have a life-time’s worth of experienced year-environments. This allows us to partition growth variation into generalizable environmental responses for years with historical weather or biotic information\, using quantitative\, genomic and ecological approaches to control for correlated responses. We focus on the economically and ecologically important conifer Norway spruce (Picea abies) to 1) develop models and infrastructure to understand the fraction of annual growth that can be attributed to genotype\, environment and genotype-by-environment interactions (GxE)\, 2) map the genetic basis of adaptive response using estimates for GxE as a response in genome-wide association studies (GWAS) and 3) predict genetic responses to novel environments. This approach enables estimation of the genetic basis of adaptive responses in any population\, providing the means to evaluate a tree’s performance in any modeled environment. As environments shift under climate change\, this provides a powerful tool to select parents for healthy\, resilient forests. \n\n\n\n\nLuisa W Hugerth\, Uppsala University\nTitle: Bridging the last mile: microbiome-enhanced forecasting of pregnancy complications \n\n\n\nAffiliation: Uppsala University \n\n\n\nBio: Luisa W. Hugerth trained both in biomedicine at Karolinska and in microbial ecology at KTH before combining these two interests by joining the Centre for Translatinal Microbiome Research. Since 2022 she is a DDLS fellow based at UU\, where she leads the Human Microbial Ecology Lab\, studying the microbiome as a modifiable risk factor in women’s health. \n\n\n\nAbstract: Patients know a lot about themselves and their health\, and asking the right questions will remain the key main strategy for taking clinical decisions. Still\, there is always uncertainty in how an individual will react to an intervention. Leveraging large population-based pregnancy cohorts and combining questionnaires\, registries\, fecal and vaginal microbiome\, we achieve improved accuracy in pregnancy complication predictions\, including preterm birth\, large-for-gestational age and small-for-gestational age infants. \n\n\n\n\nNovelty\, Excellence\, Synergy\, and Teams Projects (NEST)\n\n\n\n\nTIMED: Time-Resolved Imaging and Multi-Channel Evaluation of Cellular Dynamics. Researchers: Rocio Mercado (CHT)\, Ola Spjuth (UU)\, Ashkan Panahi (CTH)\, Prashant Singh (UU) and Brinton Seashore-Ludlow (KI)\n\n\n\nLearning 3D genome dynamics from heterogeneous data. Researchers: Thomas Schön (UU)\, Johan Elf (UU) and Magda Bienko (KI)\n\n\n\nMultimodal AI-based Precision Diagnostics and Decision Support for Breast Cancer (AID4BC). Researchers: Claes Lundström (LiU)\, Mattias Rantalainen (KI)\, Sophia Zackrisson (LU) and Dave Zachariah (UU)\n\n\n\n\n \n\n\n\nResearch Data Community Projects (RDCP)\n\n\n\n\nMicroscopy Foundation Model & AI-Ready Data Hub for Smart Microscopy\, Wei Ouyang\, KTH. Presenting: Hanzhao Zhang\, KTH\n\n\n\nTissUUmaps Research Data Community Project\, Carolina Wählby\, Uppsala University\n\n\n\nCRITICAL MICROBES – Comprehensive Research on InfecTIons Complications Across the Lifespan – MICROBiology Epidemiology in Sweden\, Sara Kalucza\, Umeå University\n\n\n\nSwedish Metabarcoding Network (SMN)\, Tobias Andermann\, Uppsala University\n\n\n\n\n \n\n\n\nThe Precision Medicine and Diagnostics and Cell and Molecular Biology parallel sessions will include selected short talks from submitted abstracts.   \n\n\n\n\nRegistration\n\n\n\nThe Poster registration is closed! If you want to update or cancel your poster\, please contact events@scilifelab.se. \n\n\n\nWe have reached full capacityWe are currently at full capacity with a waiting list. If you are no longer able to attend\, please cancel your registration as soon as possible. This will allow us to accommodate others on the waiting list and ensure a smooth experience for all attendees. The Program in Hall B will be live-broadcast to SciLifeLab YouTube Talks & Training channel. \n\n\n\nRegister for the Waiting list\n\n\n\nRegistration and Poster Submission Deadline \n\n\n\nWe have 320 seats. The registration and poster submission close on October 21st. If you register after October 21st\, you will need to write your name on a name tag at the on-site registration. Unfortunately\, we cannot accommodate allergies or dietary preferences for those who register after the deadline. \n\n\n\nWaiting List \n\n\n\nTo avoid empty seats\, registration will remain open until the event begins. If we reach full capacity\, a waiting list will be activated. Sign up for the waiting list\, and you will automatically receive an email when a spot becomes available. You must accept to secure the spot. If you decline\, the offer will go to the next person on the waiting list. \n\n\n\nCancellation \n\n\n\nTo minimize empty seats and especially food waste\, you must cancel your registration if you are unable to attend the conference. If a waiting list is activated\, your spot will go to someone else. \n\n\n\n\n\n\n\n\nPoster session\n\n\n\nPoster Abstracts\n\n\n\nPostersA3Download\n\n\n\nPoster Sessions\, November 12 \n\n\n\n14:00 15:00 Hall C: Poster session I (odd numbers) \n\n\n\n16:30 17:30 Hall C: Poster session II (even numbers) \n\n\n\nInstructions: \n\n\n\n1. Find your number in the POSTER LIST attached. \n\n\n\n2. Hang your poster on the board indicating your number\, starting at 11:00 in Hall C\, to increase visibility during lunch on Day 1. \n\n\n\n3. Please stand by your poster during your assigned session (odd or even numbers). Leave it displayed throughout the conference so everyone can see it. \n\n\n\nThe poster board area measures 103×143 cm. Bring a poster size you prefer. \n\n\n\nDDLS Annual Poster Prize\n\n\n\nThe DDLS Poster Prize encourages PhD students and postdoctoral researchers to present high-quality work in data-driven life science. The award\, decided by a Scientific Committee jury\, includes a certificate and a travel grant of up to 5\,000 SEK. Conditions apply. If you present a poster\, please ensure you stay for the Poster Award Ceremony at 12:00 by the end of the Conference. \n\n\n\n \n\n\n\nMap over UKK and the poster session (Hall C)\n\n\n\nMap UKK Floor 3 with poster session in Hall CDownload\n\n\n\nProgram\n\n\n\nThe Plenary Program (excluding the Parallel Sessions) will be live-broadcast on the SciLifeLab YouTube channel. There might be some speakers sharing unpublished data that will be excluded from the live-broadcast. \n\n\n\nProgram DDLS Annual Conference 2025_v13Download\n\n\n\n\n\n\n\nDDLS Annual Conference 2025 workshops\n\n\n\nDuring the second day of the DDLS Annual Conference\, participants will have an opportunity to attend one of three workshops. The workshops are designed for researchers in data-driven life sciences at all career stages. \n\n\n\nEach workshop has a limited number of seats on a first-come\, first-served basis. Those registered after the limit is reached will be placed on a waiting list. The workshops will take place in various rooms of the main conference venue\, UKK. All workshops start at 13:30 but can end at various times. Coffee/tea and fika will be served during the workshops. \n\n\n\nFeel free to email datacentre@scilifelab.se with any questions about workshop 1 and 2 and traininghub@scilifelab.se for workshop 3. \n\n\n\nRead more about Workshops\n\n\n\nWorkshop 1. Automating life science & biomedical tasks with LLMs and beyond: practical guide \n\n\n\nWorkshop 2. Open Source Software for Research – Sharing Code and Software the Right Way \n\n\n\nWorkshop 3. Development of a Mastery Rubric for Data Driven Life Scientists \n\n\n\nPractical information\n\n\n\nTravel to Uppsala\n\n\n\nThe Venue\, Uppsala Konsert & Kongress (UKK) is next to the Train station. MAP here! Travel centres\, bus stops\, parking and hotels are all located within walking distance from Uppsala Konsert & Kongress. Several train and bus lines connect Uppsala to the rest of the country and the region\, and Arlanda Airport is only 18 minutes by train\, Stockholm Central station is approx. 30 minutes by train. \n\n\n\nUppland public transport (UL) timetables and information: www.ul.seStockholm public transport (SL) timetables and information: www.sl.se SJ timestables and information: www.sj.se \n\n\n\nGood to know\, travelling to Uppsala. \n\n\n\nParking\n\n\n\nThe nearest parking garage is Centralgaraget. There is also parking available in Kvarnens parking garage\, Svava\, S:t Per Gallerians garage\, Österplan\, and several other locations in central Uppsala. For more information about parking in the area\, please visit Uppsala Parkering. \n\n\n\nHotels in Uppsala\n\n\n\nFind suggestions for accommodation in Uppsala here URL:https://www.scilifelab.se/event/ddls-annual-conference-2025/ LOCATION:Uppsala Konsert & Kongress (UKK)\, Vaksala torg 1\, Uppsala\, 753 31\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251111T090000 DTEND;TZID=Europe/Stockholm:20251111T100000 DTSTAMP:20260407T142012 CREATED:20251104T163529Z LAST-MODIFIED:20251104T163531Z UID:10001659-1762851600-1762855200@www.scilifelab.se SUMMARY:Epigenetic Diagnostic Classification of Cancer DESCRIPTION:Use of DNA methylation to improve diagnosis of tumors in the clinical setting \n\n\n\n\n\nClinical Genomics Webinar Series\n\n\n\nClinical Genomics Linköping is hosting this webinar as part of the Clinical Genomics Platform webinar series \n\n\n\n \n\n\n\n\nJoin us on Zoom\n\n\n\n\nThere is increasing interest in using DNA methylation information from long-read sequencing to improve the classification of tumors\, which has implications for surgical approach and treatment options. At Clinical Genomics Linköping we are exploring use of the NanoDx pipeline for classification of CNS tumors in collaboration with Dr. Eukirchen\, who developed and implemented it in Berlin. We will present some background to the method\, use on frozen tissue and liquid biopsy\, as well as some user cases from both sites.  \n\n\n\n \n\n\n\nEveryone is welcome so feel free to spread the details with anyone who may be interested. Hope to see you there! \n\n\n\nHost: Colum Walsh\, Platform site director at Clinical Genomics Linköping \n\n\n\nInvited speakers: Dr. Philipp Euskirchen\, Charité University Hospital\, Berlin and Dr. Małgorzata Łysiak\, Clinical Genomics Linköping\, Linköping University URL:https://www.scilifelab.se/event/epigenetic-diagnostic-classification-of-cancer/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2025/05/Clinical-Genomics-Webinar-series.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251110T133000 DTEND;TZID=Europe/Stockholm:20251110T140000 DTSTAMP:20260407T142012 CREATED:20251022T105523Z LAST-MODIFIED:20251022T111011Z UID:10001641-1762781400-1762783200@www.scilifelab.se SUMMARY:BiG Talk – Best practices and common pitfalls in methylome sequencing analysis DESCRIPTION:Abstract\n\n\n\nWhole-genome methylation sequencing provides single-base resolution of DNA methylation but remains one of the most computationally challenging omics data types to process. Its complexity stems from bisulfite-induced sequence conversion\, protocol-specific artifacts\, and the large number of available software tools\, making reproducible analysis and cross-study integration particularly difficult. To address this we systematically benchmarked ten complete computational workflows across five distinct profiling protocols using an experimental gold-standard reference. The results reveal substantial performance differences in accuracy\, computational efficiency\, and downstream analysis\, particularly for low-input samples. Furthermore\, we introduced a continuous\, “living” benchmarking platform for future software developments. To further facilitate large-scale\, standardized methylome analysis\, we developed complementary R package for efficient storage\, manipulation\, and integration of genome-wide methylation data that also supports applications such as methylation-based clocks\, or reference-based cell-type deconvolution enabling tissue composition inference from whole-genome methylomes. Together\, these resources address the difficulties of processing\, analyzing\, and interpreting DNA methylation data at genomic scale to ease reproducible epigenome research. \n\n\n\nBiography\n\n\n\nReka Toth is a computational biologist and group leader at the Luxembourg Institute of Health (LIH). She heads the Multi-omics Data Analysis Group in the Department of Cancer Research and drives omics initiatives within the Medical Informatics\, Bioinformatics & AI Unit. Trained as a molecular biologist\, she completed a PhD in genetic epidemiology at the University of Debrecen (Hungary) focused on chronic diseases and addiction\, and later added Software Engineering to pivot into computational biology. \n\n\n\nIn 2013\, Dr. Toth joined the National Center for Tumor Diseases in Heidelberg\, where she led the Biostatistics and Bioinformatics Group on colorectal cancer. She then moved to the Epigenomics Division at the German Cancer Research Center (DKFZ)\, expanding her work in computational epigenomics across cancer types\, with a particular emphasis on DNA methylation for prognosis and cell-of-origin. She joined LIH in 2021 and established her own group in 2025. Her research focuses on methylation as a diagnostic and prognostic biomarker and on integrative multi-omics to reveal complex biomarker signatures and mechanisms in cancer. \n\n\n\nHost: Louella Vasquez\, NBIS (louella.vasquez@scilifelab.se) \n\n\n\nBroadcast link (live event):  https://lu-se.zoom.us/j/62767371752 \n\n\n\nThe talk is sponsored by the SciLifeLab Epigenomics Symposium. \n\n\n\nA recording  will also be available on the NBIS YouTube channel. URL:https://www.scilifelab.se/event/big-talk-best-practices-and-common-pitfalls-in-methylome-sequencing-analysis/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="BiG Talks":MAILTO:info@nbis.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251110T090000 DTEND;TZID=Europe/Stockholm:20251110T170000 DTSTAMP:20260407T142012 CREATED:20250528T133817Z LAST-MODIFIED:20251107T140700Z UID:10001560-1762765200-1762794000@www.scilifelab.se SUMMARY:SciLifeLab Epigenomics Symposium DESCRIPTION:Epigenomics is a cornerstone of modern genomics\, providing crucial insights into gene regulation and cellular function. The study of epigenetic modifications\, such as DNA methylation\, histone modifications\, and non-coding RNA expression\, has revolutionized our understanding of gene activity across diverse biological systems. With advancements in sequencing technologies\, researchers can now investigate these modifications at a genome-wide level\, both in bulk tissues and at single-cell resolution. When integrated with genomic and transcriptomic data in a multimodal framework\, epigenomics offers new perspectives on gene expression regulation with broad applications in ecology\, developmental biology\, and human health\, including cancer and other diseases. \n\n\n\nWelcome to a full-day symposium with presentations from leading experts in the epigenomics field. \n\n\n\nThis event is organized in collaboration with NGI\, Clinical Genomics and NBIS. \n\n\n\nRegistration\n\n\n\nThe registration is closed. \n\n\n\n\nExtra! Hands-on Course in Epigenomics\n\n\n\nFollowing the symposium\, a four-day hands-on course will be held November 11- 14. The course combines laboratory work\, theory\, and bioinformatics training\, focused on the generation and analysis of DNA methylation data. Please visit the course page for more information and registration. \n\n\n\nRead more\n\n\n\n\nConfirmed speakers SciLifeLab Epigenomics Symposium\n\n\n\n\nPhilipp Euskirchen\, Charité – Universitätsmedizin Berlin\n\n\n\nMartí Duran-Ferrer\, FRCB-IDIBAPS\, Barcelona\n\n\n\nReka Toth\, Luxembourg Institute of Health\n\n\n\nMaja Jagodic\, Karolinska Institutet\n\n\n\nAngelica Maria Delgado-Vega\, Karolinska Institutet\n\n\n\nSofie Degerman\, Umeå University\n\n\n\nColum Walsh\, Linköping University\n\n\n\nLeif Andersson\, Uppsala University\n\n\n\nCarl-Johan Rubin\, Uppsala University\n\n\n\nAmanda Raine\, Uppsala University\n\n\n\nKatarzyna Dziasek\, SLU\n\n\n\n\nProgram\n\n\n\nSciLifeLab Epigenomics Symposium Agenda_251107Download\n\n\n\nContact for questions\n\n\n\nUlrika Liljedahl\, Ulrika.Liljedahl@medsci.uu.se \n\n\n\nOrganizers\n\n\n\nSciLifeLab Genomics NGI\, Jessica Nordlund https://www.scilifelab.se/units/ngi/ \n\n\n\nSciLifeLab Clinical Genomics\, Colum Walsh https://www.scilifelab.se/units/clinical-genomics/ \n\n\n\nNational Bioinformatics Infrastructure\, Louella Vasquez https://www.scilifelab.se/units/nbis/ \n\n\n\n\n\n\n\nWith the kind support from: URL:https://www.scilifelab.se/event/scilifelab-epigenomics-symposium/ LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden CATEGORIES:Event ORGANIZER;CN="National Genomics Infrastructure (NGI)":MAILTO:support@ngisweden.se END:VEVENT END:VCALENDAR