BEGIN:VCALENDAR VERSION:2.0 PRODID:-//SciLifeLab - ECPv6.15.18//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:SciLifeLab X-ORIGINAL-URL:https://www.scilifelab.se X-WR-CALDESC:Events for SciLifeLab REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20210328T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20211031T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20220327T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20221030T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20230326T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20231029T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221111T090000 DTEND;TZID=Europe/Stockholm:20221111T093000 DTSTAMP:20260408T101311 CREATED:20220923T085744Z LAST-MODIFIED:20220928T154812Z UID:10000687-1668157200-1668159000@www.scilifelab.se SUMMARY:[Clinical Talks] Combining AI and in situ sequencing to explore the tumor micro-environment DESCRIPTION:Carolina Wählby\n\n\n\nProfessor in quantitative microscopy\, SciLifeLab and Dept. IT\, Uppsala University \n\n\n\n\n\n\n\nCarolina Wählby is professor in Quantitative Microscopy at the Dept. of Information Technology\, Uppsala University\, and Scientific Director of the National SciLifeLab Bioimage Informatics Unit. Her research is focused on developing computational approaches for extracting information from image data with focus on precision medicine and life science. Methods include traditional image analysis as well as AI and deep learning for understanding dynamics of cancer tissue\, antibiotics susceptibility and spatial transcriptomics\, funded primarily by the ERC TissUUmaps project and the Swedish Foundation for Strategic research. She received the SBI2 President’s innovation award in 2014 for her work on in situ sequencing\, and the Thuréus prize in 2015 for development of open tools for image analysis. She is a member of the Royal Society of Sciences at Uppsala and the Royal Swedish Academy of Engineering Sciences. She has a MSc in molecular biotechnology and a PhD in digital image analysis\, and carried out postdoc research within genetics and pathology. She was part of the Imaging Platform of the Broad Institute of Harvard and MIT in 2009-2015 and became full professor at Uppsala University in 2014. She is a member of the steering group of a 300M€ effort on Data Driven Life Science\, funded by the Knut and Alice Wallenberg Foundation\, with the ambitious goal of training the next generation of life scientists. Her heart lies in the intersection between life science and computational image analysis\, and she is intrigued by the possibilities of technological developments and convergence of the scientific fields. \n\n\n\nregister to receive zoom link\n\n\n\nModerator: Päivi Östling\, SciLifeLab \n\n\n\n\n\n\n\n \n\n\n\nClinical Talks\n\n\n\nClinical Talks is back for more! With a brand new and shiny Season 6. After successfully completing 5 seasons with > 70 enthusiastic Clinical Talkers to our record\, we have barely scratched the surface of all the amazing work our clinical\, academic and industry Life Science community has to offer. More about the upcoming events is available here. \n\n\n\nThese events are co-organized by Karolinska Institutet Innovations AB and SciLifeLab\, and brought to you by Colibri Ventures. URL:https://www.scilifelab.se/event/clinical-talks-combining-ai-and-in-situ-sequencing-to-explore-the-tumor-micro-environment/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/08/Square-500x500-Clinical-Talks@4x.png ORGANIZER;CN="Clinical Talks":MAILTO:precisionmedicine@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221114T130000 DTEND;TZID=Europe/Stockholm:20221114T150000 DTSTAMP:20260408T101312 CREATED:20220622T114437Z LAST-MODIFIED:20220622T114554Z UID:10000636-1668430800-1668438000@www.scilifelab.se SUMMARY:Spatial and Single Cell Biology Webinar DESCRIPTION:The Spatial and Single Cell Biology Platform at SciLifeLab invites you to a virtual event where you can learn about the service we provide within the field of spatial and single cell omics. Take the opportunity to learn about cutting edge methods including spatial transcriptomics with Visium\, in situ sequencing\, spatial proteomics using highly multiplexed imaging\, spatial metabolomics with MALDI imaging and advanced FISH technologies. The presentations will be given by our experts in there respective methods\, working within the platform.  \n\n\n\nThe event is open for anyone to attend\, who are interested in including spatial omics in their research projects or with a general interest to learn about the methods. \n\n\n\nregister here URL:https://www.scilifelab.se/event/spatial-and-single-cell-biology-webinar-2/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="Spatial and Single Cell Biology Platform":MAILTO:charlotte.stadler@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221115T123000 DTEND;TZID=Europe/Stockholm:20221116T123000 DTSTAMP:20260408T101312 CREATED:20220630T233736Z LAST-MODIFIED:20221113T083931Z UID:10000640-1668515400-1668601800@www.scilifelab.se SUMMARY:DDLS Annual Conference DESCRIPTION:Welcome to a lunch-to-lunch conference focused on Data-driven Life Science. Listen to the DDLS Fellows and take part in social activities onsite. \n\n\n\nThe Data-Driven Life Science conference on November 15-16\, 2022\, is the first in-person conference of the DDLS program. This meeting brings together the community in biomolecular data science and AI\, introduces newly appointed DDLS fellows\, and provides opportunities for networking across the research community and SciLifeLab infrastructures. We are excited to host two international keynote speakers and welcome the community to join us. We are excited to meet in person at the poster session and other social events. \n\n\n\n \n\n\n\nDDLS Annual Conference Poster session\n\n\n\nLightning talk and Poster session \n\n\n\nThe lightning talk is 1 minute and will be strictly timed. No slides. Please\, indicate in the registration if you like to present a poster with\, or without\, a 1 min lightning talk. \n\n\n\nDDLS Annual Conference Best Poster Award \n\n\n\nThe DDLS Annual Conference Best Poster Award encourages the submission and exhibition of high-quality posters carried out by young scientists\, including Ph.D. students\, post-doctoral researchers\, etc. The poster should be on a topic related to data-driven life science. The Prize\, which is based upon the decision of a Scientific Committee-appointed Jury\, consists of a certificate and a travel grant of up to 5 000 SEK. The travel must be booked and ordered through the DDLS Support team and follow regular University travel policy. The trip should be completed before 2023-12-31. \n\n\n\n\n\n\n\nTarget group: We welcome all researchers interested in the DDLS program and data-driven life science. \n\n\n\nParticipants onsite: Venue Eva & Georg Klein\, Floor 3 (ground floor)\, Biomedicum\, Stockholm \n\n\n\nParticipate online: Online participation info\, e.g\, zoom link will be sent out upon registration \n\n\n\nOrganizer: SciLifeLab\, host of SciLifeLab & Wallenberg National Program for Data-Driven Life Science. \n\n\n\n\n\n\n\nRegister here\n\n\n\nOnsite: Register before November 9 at 12:00\, so we can order coffee and lunch. \n\n\n\n\n\n\n\n\nDownload Flyer\n\n\n\n\n\n\n\n\n\nDownload Program\n\n\n\n\n\n\n\n\nAgenda\n\n\n\nTuesday\, November 1511:45Drop-in Registration with Coffee and WrapsArea: Social area directly to the right of the entrance. You can leave your coat and bag in the Lecture Hall. We ask the participants to be seated at 12:30.12:30WelcomeTuuli Lappalainen\, KTH/SciLifeLabDDLS updatesOlli Kallioniemi\, SciLifeLab13:00Keynote: Samuli Ripatti\, Institute for Molecular Medicine\, University of HelsinkiGenetic variation and risk of common diseases over the life course13:45Coffee break14:15DDLS Fellow Talk: Tom van der Valk\, Museum of Natural HistoryEnvironmental DNA in the genomic decade14:35Infrastructures for data-driven life scienceJohan Rung\, SciLifeLab Data CentreSciLifeLab Data Centre14:45Ola Spjuth\, SciLifeLab Data CentreManaging the life cycle of AI models and apps15:00Matts Karlsson\, Linköping UniversityNAIS\, Berzelius and the road ahead15:15Poster lightning talks (1 minute per poster)Poster session with snacks and beverage17:30End of Day 1Wednesday\, November 1609:00Keynote: Cecilia Clementi\, Freie Universität BerlinDesigning molecular models with machine learning and experimental data09:45DDLS Fellow Talk: Johan Bengtsson-Palme\, Chalmers University of TechnologyUnderstanding the Evolution of Pathogenicity: Predicting and Preventing the Disease Threats of the Future10:05Announcement of DDLS Annual Conference Best Poster Award10:15Coffee break10:45DDLS Fellow Talk: Tobias Andermann\, Uppsala UniversityBig data approaches for assessing biodiversity value and potential11:05DDLS Fellow Talk: Fredrik Edfors\, Royal Institute of Technology\, KTHHarnessing the promise of next-generation plasma profiling for pan-cancer diagnostics11:25DDLS Fellow Talk: Clemens Wittenbecher\, Chalmers University of TechnologyMetabolomics profiling generates candidate biomarkers for precision nutrition approaches11:45Panel discussion: Training in Data Driven Life ScienceChair: Carolina Wählby\, Uppsala UniversityPanelists: Leslie Solorzano Vargas\, postdoc at KINina Norgren\, coordinator for DDLS education and training\, Umeå UniversityKrzysztof Jurdzinski\, PhD student at KTHDaniel Gedon\, PhD student at UU12:30Joint conference lunchProgram updated 2022-11-12\n\n\n\n\n\n\n\nAbstract\n\n\n\nCecilia Clemens\nDesigning molecular models with machine learning and experimental data. Cecilia Clemens. \n\n\n\nThe last years have seen an immense increase in high-throughput and high-resolution technologies for experimental observation as well as high-performance techniques to simulate molecular systems at a microscopic level\, resulting in vast and ever-increasing amounts of high-dimensional data. However\, experiments provide only a partial view of the molecular processes and are limited in their temporal and spatial resolution. On the other hand\, simulations are still not able to completely characterize large and/or complex molecular processes over long timescales\, thus leaving significant gaps in our ability to study these processes at a physically relevant scale. We present our efforts to bridge these gaps\, by combining statistical physics with state-of-the-art machine-learning methods to design optimal coarse models for complex macromolecular systems. We derive simplified molecular models to reproduce the essential information contained both in microscopic simulation and experimental measurements. \n\n\n\n\nSamuli Ripatti\nGenetic variation and risk of common diseases over the life course. Samuli Ripatti. \n\n\n\nPast 15 years have seen tremendous success in identifying genetic loci associated with common diseases and traits. Much of the current activities focus on strategies for inferring causal variants and genes driving these associations and on the potential translational opportunities arising from the genetic discoveries. I will highlight some of the opportunities\, risks and gaps in our knowledge related to both causal inference and genetic prediction and translation.  I will provide examples from FinnGen study (www.finngen.fi) consisting of genome wide profiles and longitudinal health registry data for  half a million Finns and from a network on biobanks and machine learning/AI -methods developers in INTERVENE Consortium (https://www.interveneproject.eu). \n\n\n\n\nJohan Bengtsson-Palme\nPredicting the disease threats of the future. Johan Bengtsson-Palme \n\n\n\nOur inability to restrain covid-19 to remain a local disease outbreak highlighted an important vulnerability in our preparedness for new infectious diseases – our inability to predict what the future disease agents might look like. This inability makes it impossible to preemptively monitor for potential future pathogens and makes it harder to quickly adapt existing disease surveillance to novel outbreaks. There is no guarantee that the next major outbreak will be viral – with increasing antibiotic resistance\, multidrug-resistant bacteria may very well be the next pandemic. In this talk\, I will discuss how we can predict which genes to look for to find future pathogens before they become widespread in clinics or among the general population\, both in terms of genes responsible for pathogenicity and in terms of antibiotic resistance genes. I will also outline how surveillance for antimicrobial resistance could be adapted to also include markers for pathogenicity and thus allow us to prevent or constrain disease outbreaks early. \n\n\n\n\nFredrik Edfors\nHarnessing the promise of next-generation plasma profiling for pan-cancer diagnostics. Fredrik Edfors \n\n\n\nCancer is one of our biggest worldwide health problems\, causing almost 10 million deaths annually. Despite significant advancements in cancer therapy over the past three decades\, diagnosis and treatment still have a great deal of opportunity for improvement.  \n\n\n\nHere\, a total of 12 prevalent cancer types represented by more than 1\,400 cancer patients’ plasma profiles of 1\,463 proteins were evaluated in trace amounts of blood plasma taken at the time of diagnosis and prior to treatment. A group of proteins linked to each of the examined malignancies was found using ML-based disease prediction models. This precision medicine strategy has the potential to benefit from advances in proteomics and precision and personalized medicine. \n\n\n\n\nTobias Andermann\nBig data approaches for assessing biodiversity value and potential. Tobias Andermann \n\n\n\nOur human societies worldwide are having a profound negative impact on the natural world surrounding us\, leading to experts declaring the current biodiversity crisis. However\, to date it is difficult if not impossible to actually quantify the magnitude of our impact on biodiversity. This is largely due to the overwhelming complexity of biodiversity\, which is not easily summarized and reduced into manageable metrics. Yet\, solving this task is necessary and is arguably one of the biggest and most urgent contemporary challenges for the biological research community. In this talk I will discuss the utility of environmental DNA (eDNA) sequencing as a tool for gathering comprehensive biodiversity data in the field. I will touch upon the challenges and possibilities regarding the application of eDNA data for this purpose\, in particular how these data can be applied to train AI models with the ability to model biodiversity and simulate changes thereof. \n\n\n\n\n \n\n\n\n\n\n\n\nScientific Committee\n\n\n\nTuuli Lappalainen\, chair and DDLS Steering group member\, Clemens Wittenbecher\, DDLS Fellow\, Simon Olsson\, WASP and Johan Rung\, Data Centre. \n\n\n\nOrganizing Committee\n\n\n\nProject leader Erika Erkstam\, Operations office\, and the DDLS support team Heidi T Persson\, Ulrika Wallenquist\, Titti Ekegren. URL:https://www.scilifelab.se/event/ddls-annual-conference/ LOCATION:Eva & Georg Klein\, Solnavägen 9\, Stockholm\, 17165\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/DDLS_cropped-Liten.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221118T140000 DTEND;TZID=Europe/Stockholm:20221118T150000 DTSTAMP:20260408T101312 CREATED:20221108T134752Z LAST-MODIFIED:20221110T155858Z UID:10000728-1668780000-1668783600@www.scilifelab.se SUMMARY:Comprehensive genomic profiling in routine cancer care - experiences from Uppsala DESCRIPTION:This webinar is jointly organized by the Clinical Genomics platform and Genomic Medicine Sweden and will focus on comprehensive genomic profiling of solid tumors in routine cancer care. Clinical\, laboratory and bioinformatic aspects will be covered. \n\n\n\nSpeakers \n\n\n\nJohan Botling\, Assoc Professor of Pathology\, Senior Consultant Histopathologist \n\n\n\nGilbert Lauter\, PhD\, molecular biologist \n\n\n\nJonas Almlöf\, PhD\, bioinformatician \n\n\n\nWhen: Friday November 18\, at 14.00-15.00 \n\n\n\nWhere: Zoom videoconference. Register to receive Zoom link. \n\n\n\nHost: Malin Melin\, Head of CG Uppsala \n\n\n\nIf you have questions about the webinar\, you are welcome to contact Eva Berglund (eva.berglund@scilifelab.uu.se) or Malin Melin (malin.melin@scilifelab.uu.se). \n\n\n\n \n\n\n\nregistration URL:https://www.scilifelab.se/event/comprehensive-genomic-profiling-in-routine-cancer-care-experiences-from-uppsala/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="Clinical Genomics Platform":MAILTO:marcela.davila@gu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221121T120000 DTEND;TZID=Europe/Stockholm:20221121T130000 DTSTAMP:20260408T101312 CREATED:20220927T104726Z LAST-MODIFIED:20220927T104815Z UID:10000697-1669032000-1669035600@www.scilifelab.se SUMMARY:Glycoproteomics - How to analyze the importance of protein glycosylation DESCRIPTION:Glycoproteomics – How to analyze the importance of protein glycosylation\n\n\n\nCarina Sihlbom \n\n\n\nChanges in the glycosylation of proteins is one of the first signs of a disease\, and advanced mass spectrometry is central for the study of such protein structure. \n\n\n\nSciLifeLab is a national infrastructure within life science with a wide range of advanced technology and expertise. The newly started SciLifeLab site in Gothenburg includes units at both the University of Gothenburg and Chalmers University of Technology and has a strong connection to Sahlgrenska University Hospital. \n\n\n\nA light lunch will be offered during the talks for those joining on site. Online participation via Zoom is also available\, please click the zoom-link below to join the event at the appointed time. \n\n\n\nVenue\n\n\n\nAssembly Room Birgit Thilander\, Medicinaregatan 3 URL:https://www.scilifelab.se/event/glycoproteomics-how-to-analyze-the-importance-of-protein-glycosylation/ LOCATION:Birgit Thilander Lecture Hall\, Medicinaregatan 3\, Göteborg CATEGORIES:Event ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221122T120000 DTEND;TZID=Europe/Stockholm:20221122T130000 DTSTAMP:20260408T101312 CREATED:20221116T135205Z LAST-MODIFIED:20221116T135206Z UID:10000731-1669118400-1669122000@www.scilifelab.se SUMMARY:National support with superresolution light microscopy DESCRIPTION:In the frame of the “SciLifeLab Site Umeå / KBC Infrastructure Seminar Series”\, the seminars will be organised every second Tuesday during autumn 2022\, in turn with IceLab Lunch Pitches. The seminars will be held in a hybrid format IRL in Glasburen\, KBC\, and online via Zoom. Take the chance to get information on facilities\, possibilities and services that infrastructure\, both SciLifeLab-associated and local\, can offer! Learn more about the seminar series and the schedule for autumn 2022 here. \n\n\n\nOn November 22nd\, 12:00-13:00\, you are welcome to participate in the seminar \n\n\n\nNational support with superresolution light microscopy \n\n\n\nby Hans Blom\, Royal Institute of Technology (KTH)\, Head of the Advanced Light Microscopy (ALM) Unit\, SciLifeLab \n\n\n\n\nMore information about the national SciLifeLab facility Integrated Microscopy Technologies.\n\n\n\nAbout Hans Blom \n\n\n\n\nregistration\n\n\n\nRegistration deadline: Monday\, November 21st\, 10:00. \n\n\n\nOnline attendance: You can also join the seminar on Zoom\, https://umu.zoom.us/j/63138997026 \n\n\n\nOrganisers: SciLifeLab Site Umeå and Chemical Biological Centre (KBC) URL:https://www.scilifelab.se/event/national-support-with-superresolution-light-microscopy/ LOCATION:Glasburen Seminar Room\, Chemical Biological Centre (KBC) Building\, Umeå University\, Umeå\, 901 87\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221124T080000 DTEND;TZID=Europe/Stockholm:20221125T170000 DTSTAMP:20260408T101312 CREATED:20221020T085403Z LAST-MODIFIED:20221020T085458Z UID:10000718-1669276800-1669395600@www.scilifelab.se SUMMARY:Aquatic Microbiome Research Initiative -All-Hands meeting DESCRIPTION:This year’s AMRI All-Hands meeting will feature speakers from EMBL\, Centro Nacional de Biotecnología\, Umeå University\, and the LEAF sustainable lab program. \n\n\n\nRead more and register\n\n\n\nThe evening of the 24th we will welcome all AMRI participants on an excursion to the Baltic Sea Science Centre\, followed by a dinner. \n\n\n\n**A dinner for postdocs and early career researchers is scheduled for the evening of November 23rd\, to be followed by a morning workshop designed for postdocs and early careers on November 24th. \n\n\n\nAMRI covers the cost of travel and accommodations for those traveling from outside the Stockholm/Uppsala area. URL:https://www.scilifelab.se/event/aquatic-microbiome-research-initiative-all-hands-meeting/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/10/Skärmavbild-2022-10-20-kl.-10.53.45.png ORGANIZER;CN="Aquatic Microbiome Research Initiative":MAILTO:caroline.littlefield@ebc.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221124T090000 DTEND;TZID=Europe/Stockholm:20221124T170000 DTSTAMP:20260408T101312 CREATED:20221019T130435Z LAST-MODIFIED:20221117T161827Z UID:10000715-1669280400-1669309200@www.scilifelab.se SUMMARY:SciLifeLab Platform Day - Uppsala site DESCRIPTION:This day will be held to promote and introduce an array of SciLifeLab infrastructure platforms based in Uppsala. \nVenue: Trippelrummet\, and on ZoomTime: 9:00-17:00 \n\n\nREGISTER HERE\n\n\n\nSEE THE PROGRAM HERE URL:https://www.scilifelab.se/event/scilifelab-platform-day/ LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2020/05/mötestorget-1-scaled.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221124T150000 DTEND;TZID=Europe/Stockholm:20221124T160000 DTSTAMP:20260408T101312 CREATED:20221109T093512Z LAST-MODIFIED:20221109T100336Z UID:10000729-1669302000-1669305600@www.scilifelab.se SUMMARY:Research seminar - Distributing biotechnology and hardware to advance research and health care DESCRIPTION:Research seminar with Keith Pardee\nWhere: Lunch room in Gamma-building floor 2 at SciLifeLab. If you don’t have an access card\, wait in the SciLifeLab LobbyWhen: Thursday 24th November\, at 3 pm (The early birds will be served some fika\, so be there on time) \nKeith PardeeAssociate professor\, Leslie Dan Faculty of Pharmacy\, University of TorontoCanada Research Chair in Synthetic Biology and Human HealthCo-Director\, PRiME\, Precision Medicine Initiative\, Medicine by Design Investigator \nBio \nProf. Keith Pardee is working at the intersection of synthetic biology and human health. His lab is pioneering the development of in vitro devices to host cell-free synthetic gene networks for broad applications in research and human health. Pardee’s research interests include the development of molecular diagnostic tools for communicable diseases like Zika virus\, distributed drug manufacturing\, and regenerative medicine. \nHe is also the co-founder of several companies and initiatives including PRiME: A Precision Medicine Initiative\, En Carta Diagnostics\, Medicine by Design 2.0\, LSK Technologies\, and Liberum Biotech. \nhttps://www.pardeelab.org/ URL:https://www.scilifelab.se/event/research-seminar-distributing-biotechnology-and-hardware-to-advance-research-and-health-care/ LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221128T120000 DTEND;TZID=Europe/Stockholm:20221128T130000 DTSTAMP:20260408T101312 CREATED:20220927T104822Z LAST-MODIFIED:20220927T104912Z UID:10000698-1669636800-1669640400@www.scilifelab.se SUMMARY:The Centre for Cellular Imaging - A research infrastructure for correlated multimodal imaging DESCRIPTION:The Centre for Cellular Imaging – A research infrastructure for correlated multimodal imaging\n\n\n\nJulia Fernandez-Rodriguez \n\n\n\nThe CCI specializes in 3D correlative imaging\, i.e. the sequential combination of two or more imaging techniques to gain knowledge across multiple scales \n\n\n\nSciLifeLab is a national infrastructure within life science with a wide range of advanced technology and expertise. The newly started SciLifeLab site in Gothenburg includes units at both the University of Gothenburg and Chalmers University of Technology and has a strong connection to Sahlgrenska University Hospital. \n\n\n\nA light lunch will be offered during the talks for those joining on site. Online participation via Zoom is also available\, please click the zoom-link below to join the event at the appointed time. \n\n\n\nVenue\n\n\n\nAssembly Room Birgit Thilander\, Medicinaregatan 3 URL:https://www.scilifelab.se/event/the-centre-for-cellular-imaging-a-research-infrastructure-for-correlated-multimodal-imaging/ LOCATION:Birgit Thilander Lecture Hall\, Medicinaregatan 3\, Göteborg CATEGORIES:Event ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221129T090000 DTEND;TZID=Europe/Stockholm:20221129T163000 DTSTAMP:20260408T101312 CREATED:20220923T175028Z LAST-MODIFIED:20221128T154333Z UID:10000690-1669712400-1669739400@www.scilifelab.se SUMMARY:Ancient DNA symposium DESCRIPTION:SciLifeLab Ancient DNA. Photo. Mikael Wallerstedt.\n\n\n\nThe possibility of studying humans\, animals\, plants\, and other forms of life that lived in the past using DNA analysis is providing new insight into history\, often with important implications for understanding our contemporary world. Ancient DNA can support investigation of e.g. prehistoric migrations and interactions\, cultural practices\, and development of agriculture\, as well as research into evolution\, ecology\, and biodiversity. \n\n\n\nThis symposium is organized to present the forefront and breadth of ancient DNA analysis and its value in context of other information in order to facilitate cross-disciplinary projects. \n\n\n\nThe event is organized by the Centre for Palaeogenetics at Stockholm University and Swedish Museum of Natural History\, in collaboration with SciLifeLab Ancient DNA unit and the National Genomics Infrastructure. \n\n\n\nThe symposium is free of charge. Deadline for registration is November 18th for on-site participation. \n\n\n\nDuring the coffee breaks\, representatives of SciLifeLab Ancient DNA unit\, the National Genomics Infrastructure (NGI)\, and the National Bioinformatics Infrastructure Sweden (NBIS) are available for project discussions. \n\n\n\nIf you are unable to join the meeting physically\, you can take part in all presentations online. Please register below to receive the link. \n\n\n\n\n\n\n\nRegistration\n\n\n\nPlease register for online participation. Registration for on-site participation is closed. \n\n\n\n\n\n\n\nProgram and Abstracts\n\n\n\n2022-Ancient-DNA-symposium-program-and-abstracts-1Download URL:https://www.scilifelab.se/event/ancient-dna-symposium/ LOCATION:Large auditorium\, Swedish Museum of Natural History\, Frescativägen 40\, Stockholm\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/21A0115-scaled.jpg ORGANIZER;CN="Ancient DNA Unit at SciLifeLab":MAILTO:magnus.lundgren@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221130T090000 DTEND;TZID=Europe/Stockholm:20221130T110000 DTSTAMP:20260408T101312 CREATED:20221013T073408Z LAST-MODIFIED:20221130T172719Z UID:10000714-1669798800-1669806000@www.scilifelab.se SUMMARY:DDLS Industry PhD Collaboration Dialogue - online DESCRIPTION:The SciLifeLab and Wallenberg National Program for Data-Driven Life Science (DDLS) is a national 12-year research program that involves 11 partner organizations\, collaborators nationally and internationally\, the Swedish life science community\, industry\, healthcare\, and other stakeholders in society at large. \n\n\n\nDuring the program\, more than 250 PhD students and 200 postdocs in academia and industry will be recruited to facilitate collaborations across sectors and disciplines. The DDLS academic and industrial PhD students and postdocs will all be enrolled in the DDLS Research School promoting acquisition of high competence and skills. This is to meet the future needs within data-driven life sciences\, industrial R&D\, health care and society. The DDLS Research School will be launched in 2024. \n\n\n\nNow\, both well established companies\, small and medium-sized enterprises\, within the data-driven life science sector as well as academia\, are invited to partake in this event and contribute to the future of the program. \n\n\n\n \n\n\n\nAim\n\n\n\nThe aim of this event is to: \n\n\n\n\nInform about the program and KAW donation letter that specifies industrial PhDs and Postdocs.\n\n\n\nInform about the DDLS Research School\, timeline and recruiting models for industrial PhDs.\n\n\n\nEngage industry in the DDLS Program (e.g.\, being part of the DDLS review committees and involved in decisions and other types of evaluations regarding the DDLS research school).\n\n\n\nDiscuss how industry would like to contribute to the the DDLS Research School and the program.\n\n\n\n\n\n\n\n\nPreliminary Agenda\n\n\n\n\nWelcome\n\n\n\nPresentation of the DDLS program\n\n\n\nOverview of the DDLS Research School\n\n\n\nRecruitment Models for DDLS PhD Program – Academia & Industry\n\n\n\nDiscussion/Dialogue\n\n\n\n\n\n\n\n\nRegistration\n\n\n\nRegister as soon as possible but no later than November 28th. \n\n\n\nRegister here\n\n\n\n\n\n\n\nContact\n\n\n\nMojgan Seraji (contact information below) or DDLS support team: ddls@scilifelab.se \n\n\n\n\n\n\n\n \n\n\n\nMojgan SerajiCollaboration ManagerProject leading\, SciLifeLab Code of Conduct\, DDLS PhD & Postdoc Programs\, DDLS Industry CollaborationMojgan.Seraji@scilifelab.uu.se +46 (0) 73 46 97 306 URL:https://www.scilifelab.se/event/ddls-industry-phd-collaboration-dialogue-online/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221130T160000 DTEND;TZID=Europe/Stockholm:20221130T170000 DTSTAMP:20260408T101312 CREATED:20221128T170202Z LAST-MODIFIED:20221130T131842Z UID:10000741-1669824000-1669827600@www.scilifelab.se SUMMARY:Biophysical experiments and biomolecular simulations: A perfect match? DESCRIPTION:Abstract-BRAINSTRUC__lindorff__Download\n\n\nA special seminar by Professor Kresten Lindorff-Larsen\, University of Copenhagen URL:https://www.scilifelab.se/event/biophysical-experiments-and-biomolecular-simulations-a-perfect-match/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="Molecular Biophysics Stockholm":MAILTO:join-mbp@scilifelab.se. END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221130T170000 DTEND;TZID=Europe/Stockholm:20221130T180000 DTSTAMP:20260408T101312 CREATED:20221116T151917Z LAST-MODIFIED:20221116T152937Z UID:10000732-1669827600-1669831200@www.scilifelab.se SUMMARY:FAIRPoints-Introducing Community Guidelines for Sharing Dataset Quality Information DESCRIPTION:Location: Online via Zoom \n\n\n\n\n\nSee Event in your Time Zone \n\n\n\nSpeaker: Dr.Ge Peng \n\n\n\nKnowledge about the quality of data and associated metadata\, software\, workflows and computing environment is important to establish the trustworthiness of individual datasets\, support informed decisions on their (re)use\, and is an essential part of the diverse data and information distribution ecosystem that supports open-source science. However\, quality information\, being difficult to curate and often context-specific\, is currently not readily available for sharing within and across disciplines. \n\n\n\nTo help address this challenge\, and to promote the creation and (re)use of freely and openly shared dataset quality information\, members of multiple\, international groups collaborating with domain experts have undertaken the development of community guidelines with practical recommendations for the Earth science community. The guidelines follow the guiding principles of being findable\, accessible\, interoperable\, and reusable (FAIR). \n\n\n\nThe FAIR dataset quality information guidelines are intended to help stakeholders\, such as scientific data centers\, digital data repositories\, and producers\, publishers\, stewards and managers of data\, to achieve the following: i) capture\, describe\, and represent quality information of their datasets in a manner that is consistent with the FAIR guiding principles; ii) allow for the maximum discovery\, trust\, sharing\, and reuse of their datasets; and iii) enable international access to and integration of dataset quality information. \n\n\n\nBio: \n\n\n\nDr.Ge Peng is currently a Senior principal research scientist from the University of Alabama in Huntsville (UAH)\, supporting the NASA Interagency Implementation and Advanced Concepts Team (IMPACT) Project. With a Ph.D. in meteorology and a primary research focus on exploring the variability of essential climate variables of Earth atmosphere\, ocean\, and cryosphere\, she has worked with various types of Earth observations and derived data products. She has first-hand experience of the challenges in finding and obtaining data quality information\, which led her to find ways to systematically evaluate data quality as well as document and share quality information. Dr. Peng is a strong advocate of promoting scientific data stewardship and open science. She has volunteered for organizations that strive to minimize the barrier to data and information sharing\, such as the Earth System Science Data (ESSD) Journal\, the World Meteorological Organization (WMO)\, and the Earth Science Information Partners (ESIP). Dr. Peng is a leading author of several data stewardship assessment models for national and international Earth science organizations and has published a number of peer-reviewed papers on trends and variability of climate data\, research data management and stewardship. \n\n\n\n \n\n\n\nFAIRPoints is an event series highlighting pragmatic measures developed by the community towards the implementation of the FAIR (Findable\, Accessible\, Interoperable\, Reusable) data principles\, in collaboration with GoFAIR US\, SDSC\, and SciLifeLab Data Centre.  \n\n\n\n\n\n\n\nRegister here\n\n\n\nSign up for future events here \n\n\n\nTwitter: @FAIR_Points URL:https://www.scilifelab.se/event/fairpoints-introducing-community-guidelines-for-sharing-dataset-quality-information/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221201T173000 DTEND;TZID=Europe/Stockholm:20221201T180000 DTSTAMP:20260408T101312 CREATED:20220831T154601Z LAST-MODIFIED:20221110T115015Z UID:10000665-1669915800-1669917600@www.scilifelab.se SUMMARY:[Clinical Talks] Recording biology to the genome itself DESCRIPTION:Jay Shendure\n\n\n\nProfessor of Genome Sciences at the University of Washington \n\n\n\n\n\n\n\nJay Shendure is a Investigator of the Howard Hughes Medical Institute\, Professor of Genome Sciences at the University of Washington\, Director of the Allen Discovery Center for Cell Lineage Tracing\, and Scientific Director of the Brotman Baty Institute for Precision Medicine. \n\n\n\nHis 2005 doctoral thesis with George Church included one of the first successful reductions to practice of next generation DNA sequencing. Dr. Shendure’s research group in Seattle pioneered exome sequencing and its earliest applications to gene discovery for Mendelian disorders and autism; cell-free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays\, saturation genome editing; whole organism lineage tracing\, and massively parallel molecular profiling of single cells.Dr. Shendure is the recipient of the Curt Stern Award from the American Society of Human Genetics (2012)\, the Richard Lounsbery Award from the National Academy of Sciences (2019) and the Mendel Award from the European Society of Human Genetics (2022) and is an elected member of the American Association for the Advancement of Science (AAAS) and the National Academy of Sciences (NAS). He serves or has previously served as an advisor to the NIH Director\, the US Precision Medicine Initiative\, the National Human Genome Research Institute\, the Chan-Zuckerberg Initiative and the Allen Institutes for Cell Science and Immunology. He received his MD and PhD degrees from Harvard Medical School in 2007. \n\n\n\nregister to receive zoom link\n\n\n\nModerator: Michael Akhras\, Colibri Ventures \n\n\n\n\n\n\n\n \n\n\n\nClinical Talks\n\n\n\nClinical Talks is back for more! With a brand new and shiny Season 6. After successfully completing 5 seasons with > 70 enthusiastic Clinical Talkers to our record\, we have barely scratched the surface of all the amazing work our clinical\, academic and industry Life Science community has to offer. More about the upcoming events is available here. \n\n\n\nThese events are co-organized by Karolinska Institutet Innovations AB and SciLifeLab\, and brought to you by Colibri Ventures. URL:https://www.scilifelab.se/event/clinical-talks-recording-biology-to-the-genome-itself/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/08/Square-500x500-Clinical-Talks@4x.png ORGANIZER;CN="Clinical Talks":MAILTO:precisionmedicine@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221206T090000 DTEND;TZID=Europe/Stockholm:20221206T184500 DTSTAMP:20260408T101312 CREATED:20220919T142908Z LAST-MODIFIED:20221124T091417Z UID:10000683-1670317200-1670352300@www.scilifelab.se SUMMARY:SciLifeLab Optical Clearing and Expansion symposium DESCRIPTION:The Advanced Light Microscopy unit at Science for Life laboratory cordially welcomes you to a symposium on developments and applications of clearing and expansion methods from world leading experts. \n\n\n\nRegistration\n\n\n\nRegistration form\n\n\n\n\n\n\n\nProgram\n\n\n\n12:45Whole-body/organ imaging with single-cell resolution by CUBICHiroki Ueda – University Tokyo/Riken BDR\, Japan13:15DISCO clearing approaches paired with spatial molecular mappingHarsharan Bhatia\, Helmholtz Munich\, Germany13:45Volumetric imaging of cleared samplesJacques Paysan – ZEISS14:15Coffee break14:40Expansion Microscopy: Development\, Application\, and Future DirectionsJinyoung Kang – MIT\, USA15:10Pan-ExM-t for molecular ultrastructural visualization of brain tissueOns M’Saad – Yale University\, USA15:40Coffee break16:05Cryo-ExM: coupling cryo-fixation with expansion microscopyVirginie Hamel – University of Geneva\, Switzerland16:35Visualizing cellular and tissue ultrastructure using TRExHugo Damstra – Utrecht University\, The Netherlands17:15-18:45POSTER session with snacks/beverages\n\n\n\n Contact\n\n\n\nhans.blom@scilifelab.se URL:https://www.scilifelab.se/event/scilifelab-optical-clearing-and-expansion-symposium/ LOCATION:Eva & Georg Klein\, Solnavägen 9\, Stockholm\, 17165\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/09/Ny-Bild-Dec-6.png ORGANIZER;CN="Advanced Light Microscopy Unit":MAILTO:stewen@kth.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221206T120000 DTEND;TZID=Europe/Stockholm:20221206T130000 DTSTAMP:20260408T101312 CREATED:20220927T104924Z LAST-MODIFIED:20221201T154038Z UID:10000699-1670328000-1670331600@www.scilifelab.se SUMMARY:Cancelled: OligoNova Hub - National resource for development of oligonucleotide therapies DESCRIPTION:OligoNova Hub – National resource for development of oligonucleotide therapies\n\n\n\nPär Matsson \n\n\n\nWe will present OligoNova Hub and the capabilities we provide for academic researchers to transform their scientific discoveries into new oligonucleotide therapies. \n\n\n\nSciLifeLab is a national infrastructure within life science with a wide range of advanced technology and expertise. The newly started SciLifeLab site in Gothenburg includes units at both the University of Gothenburg and Chalmers University of Technology and has a strong connection to Sahlgrenska University Hospital. \n\n\n\nA light lunch will be offered during the talks for those joining on site. Online participation via Zoom is also available\, please click the zoom-link below to join the event at the appointed time. \n\n\n\nVenue\n\n\n\nThis event has been cancelled. URL:https://www.scilifelab.se/event/oligonova-hub-national-resource-for-development-of-oligonucleotide-therapies/ LOCATION:Birgit Thilander Lecture Hall\, Medicinaregatan 3\, Göteborg CATEGORIES:Event ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221207T130000 DTEND;TZID=Europe/Stockholm:20221208T130000 DTSTAMP:20260408T101312 CREATED:20221026T084455Z LAST-MODIFIED:20221109T150910Z UID:10000722-1670418000-1670504400@www.scilifelab.se SUMMARY:Data-driven Epidemiology and biology of infections Research Area Symposium DESCRIPTION:Welcome to a symposia with the new DDLS Fellows and national as well as international researchers within the area of data-driven epidemiology and biology of infections. \n\n\n\nWe encourage personal participation to network with the new DDLS Fellows and other experts of the field however online participation is possible. \n\n\n\nDeadline for registration November 29th \n\n\n\n\n\n\n\nRegister here\n\n\n\nProgram Wednesday\, 7 December\n\n\n\n12:00 LUNCH will be served \n\n\n\n13:00- 13:20 Welcomes and Introductions \n\n\n\nSiv Andersson\, Head of Basic Research at Knut and Alice Wallenberg Foundation\, Uppsala University\, \n\n\n\nOlli Kallioniemi\, Director SciLifeLab and DDLS Director\, Karolinska Institutet \n\n\n\nMaria Smedh Site Coordinator\, SciLifeLab Göteborg \n\n\n\n13:20 DDLS in Epidemiology and Biology of Infection \n\n\n\nOliver Billker\, DDLS Research Area Lead\, Umeå University \n\n\n\n13:30 Keynote: Using genomic surveillance data to understand bacterial epidemiology \n\n\n\nNicholas J Croucher\, Imperial College London \n\n\n\n14:10 DDLS Fellow talk: Predicting the disease threats of the future \n\n\n\nJohan Bengtsson-Palme\, DDLS Fellow at Chalmers University of Technology \n\n\n\n14:50 Keynote (virtual) Data and decisions in an imperfect world \n\n\n\nBill Hanage\, Associate Professor\, Harvard\, School of Public Health \n\n\n\n15:30 COFFEE \n\n\n\n16:00 DDLS Fellow talk: A global perspective on antimicrobial resistance in animals raised for food \n\n\n\nThomas van Boeckel\, ETH Zurich and future DDLS Fellow at Gothenburg University \n\n\n\n16:40 Pandemic preparedness – The SciLifeLab perspective \n\n\n\nStaffan Svärd\, SciLifeLab Scientific Director\, Uppsala University \n\n\n\n17:10 Discussion and conclusion of the first day \n\n\n\n17:30 Snacks and mingle in Restaurant Nordic \n\n\n\n18:30 SYMPOSIUM DINNER in Restaurant Nordic \n\n\n\n\n\n\n\nProgram Thursday\, 8 December\n\n\n\n8:30 DDLS Fellow Talk: Strength in numbers: leveraging publicly available (meta)genomic data to gain insight into the epidemiology and virulence potential of bacterial pathogens \n\n\n\nLaura Michelle Carroll\, Umeå University \n\n\n\n9:10 Keynote: Data-driven dynamic disease surveillance and studies for mapping systemic effects of the human gut microbiome \n\n\n\nTove Fall\, Uppsala University \n\n\n\n9:50 COFFEE \n\n\n\n10:20 DDLS Fellow Talk: Intimately microbial: symbioses in OB-GYN\, \n\n\n\nLuisa Warchavchik Hugerth\, DDLS Fellow Uppsala University \n\n\n\n11:00 National services for data and bioinformatics within DDLS and SciLifeLab \n\n\n\nSara El-Gebali\, SciLifeLab Data Centre\, \n\n\n\nBjörn Nystedt\, National Bioinformatics Infrastructure \n\n\n\nShort presentations followed by a discussion to determine needs for computational support for infections research in Sweden. \n\n\n\n12:00 Discussion: DDLS initiative and Data-Driven Epidemiology and Biology of Infection: where next? \n\n\n\n12:30 LUNCH will be served URL:https://www.scilifelab.se/event/data-driven-epidemiology-and-biology-of-infections-research-area-symposium/ LOCATION:Europasalen\, Konferenscentrum Wallenberg\, Gothenburg\, Medicinaregatan 20\, Göteborg\, 413 90\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221208T093000 DTEND;TZID=Europe/Stockholm:20221208T123000 DTSTAMP:20260408T101312 CREATED:20221019T101155Z LAST-MODIFIED:20221206T121942Z UID:10000716-1670491800-1670502600@www.scilifelab.se SUMMARY:Science & SciLifeLab Prize Symposium DESCRIPTION:Welcome to the Scientific Symposium presenting the winners of the 2022 Science & SciLifeLab Prize for Young Scientists. \n\n\n\nYou can still register to join on Zoom and onsite if seats are available. For onsite registration\, we can not consider special food requirements after November 30. \n\n\n\n\n\n\n\nregistration\n\n\n\n\n\n\n\nScience\, the American Association for the Advancement of Science (AAAS)\, and SciLifeLab joined forces in 2013\, creating the Science & SciLifeLab Prize for Young Scientists to recognize excellence amongst young researchers from around the world. A global Prize aimed at rewarding scientists at an early stage of their careers.  \n\n\n\nThe Prize was launched with the vision of recognizing that global economic health depends on a vibrant research community. A vision that will only come true if we encourage our best and brightest to continue in their chosen fields of research. \n\n\n\nConsidering the difficult economic environment for budding scientists\, it is crucial that we provide them with extra encouragement as they begin their scientific careers. \n\n\n\nThe international Prize is awarded annually to four young scientists for outstanding life science research based on a doctoral degree earned in the previous two years. Each year\, a Grand Prize winner is selected from the applicants to receive 30\,000 USD in prize money\, and the three other category winners are awarded 10\,000 USD each for their accomplishments. The grand prize-winning essay will be published in Science\, and essays from the three category winners will be published online. \n\n\n\nAll four winners of the Science & SciLifeLab Prize for Young Scientists are invited to Sweden December 6-11 to participate in a unique week filled with events in honor of science. They will have the opportunity to meet with leading scientists in their field of research and create life-long connections to support their careers.  \n\n\n\n \n\n\n\nProgram\n\n\n\n\n\n\n\n09:00Breakfast is served outside the Lecture Hall09:30Welcome words:Olli Kallioniemi\, SciLifeLab Director Valda Vinson\, Science AAAS09:45The winners present their research (15’+5′)Moderators: Alexandra Teleki & Mikael Sellin\, SciLifeLab FellowsEndosomes\, Receptors and Viruses: Deciphering the Mechanisms of Infection at the Host-Pathogen Interface  James Daly\, Cell & Molecular Biology Category Prize WinnerUncovering the Degrader of D-type Cyclins Daniele Simoneschi\, Molecular Medicine Category Prize WinnerCoffee break How do bacteria cope with a changing world?  Stefany Moreno-Gámez\, Ecology and Environment Category Prize WinnerThe autobiography of a gut bacterium  Florian Schmidt\, Proteomics and Systems Biology Approaches\, Grand Prize Winner11:35Interview with the WinnersModerators: Alexandra Teleki & Mikael Sellin\, SciLifeLab Fellows11:55Keynote lecture: Rediscover Your Why – Don’t Lose Sight of Why You Pursued Scientific InquiryGilda A. Barabino\, President of the American Association for the Advancement of Science (Bio below)12:25Closing words:Mia Phillipson\, SciLifeLab Co-Director12:30Lunch is served\n\n\n\n\n\n\n\nBooklet\n\n\n\nGilda A. Barabino – Bio\n\n\n\n\n\n\n\n\n\n\n\nPlease contact events@scilifelab.se if you have any questions. URL:https://www.scilifelab.se/event/science-scilifelab-prize-symposium/ LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/12/Prize_2022_Sida_01.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221212T090000 DTEND;TZID=Europe/Stockholm:20221212T160000 DTSTAMP:20260408T101312 CREATED:20221107T094021Z LAST-MODIFIED:20221212T094712Z UID:10000727-1670835600-1670860800@www.scilifelab.se SUMMARY:SciLifeLab Integrated Structural Biology Platform Symposium DESCRIPTION:SciLifeLab Integrated Structural Biology invites you to the ISB annual users meeting to be held in Solna on December 12\, 9-16.  \n\n\n\n The program will contain an overview of infrastructures in Sweden that can support your structural biology project\, from gene to final 3D structure. We will also hear examples of projects that were supported by the SciLifeLab infrastructures during 2022\, comprising Cryo-EM\, Structural Proteomics and NMR. \n\n\n\n We welcome you to join in person in the SciLIfeLab building (Tomtebodavägen 23\, 171 65 Solna) but also understand if you prefer to join in by zoom. The meeting will be a hybrid meeting. \n\n\n\nRegistration\n\n\n\n \n\n\n\n \n\n\n\nProgram\n\n\n\nProgram – December 12 \n\n\n\nISB2022_221212Download URL:https://www.scilifelab.se/event/scilifelab-integrated-structural-biology-platform-symposium/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="Integrated Structural Biology Platform at SciLifeLab":MAILTO:cecilia.persson@nmr.gu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221212T100000 DTEND;TZID=Europe/Stockholm:20221212T183000 DTSTAMP:20260408T101312 CREATED:20220927T190428Z LAST-MODIFIED:20221212T092442Z UID:10000701-1670839200-1670869800@www.scilifelab.se SUMMARY:Data-Driven Precision Medicine and Diagnostics Research Area Symposium DESCRIPTION:Welcome to the first in-person symposium in data-driven precision medicine and diagnostics (PMD) research area. Listen to the Data Driven Life Science (DDLS) fellows recruited in this research area and expand your network with international and national colleagues. \n\n\n\nThe data-driven precision medicine and diagnostics symposium on December 12\, 2022\, is the first in-person symposium in the research area of precision medicine and diagnostics of the DDLS program. This meeting brings together the community in precision medicine and diagnostics and researchers who implemented artificial intelligence and machine learning applications in their research in PMD to improve human health and diagnostics\, introduces newly appointed DDLS fellows in the PMD research area\, and provides opportunities for networking across the research community and the SciLifeLab infrastructures. We are excited to host three international keynote speakers and welcome the community to join us. Hopefully\, this event will inspire you on the potentials of data-driven precision medicine and diagnostics in Sweden. \n\n\n\nTarget group: We welcome all researchers interested in the DDLS program and data-driven precision medicine and diagnostics. \n\n\n\nVenue: Sune Bergström Aula\, BioClinicum\, New Karolinska University Hospital\, Solnavägen 30\, Stockholm \n\n\n\nOrganizer: SciLifeLab\, host of SciLifeLab & Wallenberg National Program for Data-Driven Life Science. \n\n\n\nDeadline for registration extended to December 12th 9 am (earlier 2nd of December). \n\n\n\n\n\n\n\nAgenda & speaker bios\n\n\n\nRegister here\n\n\n\n\n\n\n\nAGENDA\n\n\n\nTimeSession/Title of the presentationPresenter10.00Registration10:15Welcome and Introduction to Precision Medicine and Diagnostics Research AreaJanne Lehtiö10:30Scientific presentations – Precision Medicine  Chair: Fulya Taylan  Opening Keynote: FinnGen: a public-private partnership improving human health through genetic researchMervi Aavikko Genomic Medicine Sweden: Lessons learned and future possibilities within the Swedish health data spacePer Sikora Implementation of an academic clinical decision support system for precision oncology: the Molecular Tumor Board Portal (Digital)David Tamborero11:40Lunch 12:45Scientific presentations – Imaging and AI for Precision Medicine  Chair: Magnus Boman  AIDA – supporting AI research in diagnostic imagingClaes Lundström AI-based precision pathology – scalable solutions for cancer patient stratification and phenotypingMattias Rantalainen Deep learning for PET image analysisIda Häggström 13:40Scientific presentations – Digital Twins in Healthcare  Chair: Päivi Östling Building an ecosystem for digital twins in healthcareLiesbet Geris M4-health and digital twins: bring a digital copy of yourself with you throughout your health journeyGunnar Cedersund Towards precision prevention of rheumatoid arthritis; novel tools and novel resultsLars Klareskog14:35Coffee break 15:00SciLifeLab and DDLS Precision Medicine and Diagnostics  Chair: Janne Lehtiö  Introduction to SciLifeLab and DDLS ProgramOlli Kallioniemi SciLifeLab’s Data Center and Precision Medicine & Diagnostics Data Science NodeJohan Rung Bioinformatics support for Precision Medicine and DiagnosticsPär Engström Q&A sessionJanne Lehtiö16:00DDLS Fellows  Chair: Åsa Johansson  Deep lipidomics profiling provides potential biomarkers for precision nutrition approaches in cardiometabolic disease preventionClemens Wittenbecher Integrative multi-omics for precision medicineWen Zhong Harnessing the promise of next-generation plasma profiling for pan-cancer diagnosticsFredrik Edfors 17:00Closing Keynote  Chair: Janne Lehtiö  The need to model OMICs and routine (para)clinical data together – CLL as an example (Digital)Carsten Utoft Niemann17:30 – 18:30Networking with drinks  URL:https://www.scilifelab.se/event/data-driven-precision-medicine-and-diagnostics-research-area-symposium/ LOCATION:Sune Bergström Aula\, BioClinicum\, New Karolinska University Hospital\, Solnavägen 30\, Stockholm\, 17164\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221213T120000 DTEND;TZID=Europe/Stockholm:20221213T130000 DTSTAMP:20260408T101312 CREATED:20220927T105016Z LAST-MODIFIED:20221212T135834Z UID:10000700-1670932800-1670936400@www.scilifelab.se SUMMARY:Cancelled: SciLifeLab Metabolomics platform - Metabolomics for the masses DESCRIPTION:SciLifeLab Metabolomics platform – Metabolomics for the masses\n\n\n\nOtto Savolainen \n\n\n\nThis event is cancelled \n\n\n\nMetabolites reflect the interaction between the gene cascade and surrounding exposures and are therefore essential components in all living organisms. Metabolites can be used to identify biomarkers of both health conditions and environmental exposures. The SciLifeLab Metabolomics platform offers a range of services for resaerchers interested in metabolomics. \n\n\n\nSciLifeLab is a national infrastructure within life science with a wide range of advanced technology and expertise. The newly started SciLifeLab site in Gothenburg includes units at both the University of Gothenburg and Chalmers University of Technology and has a strong connection to Sahlgrenska University Hospital. \n\n\n\nA light lunch will be offered during the talks for those joining on site. Online participation via Zoom is also available\, please click the zoom-link below to join the event at the appointed time. \n\n\n\nVenue\n\n\n\nAssembly Room Birgit Thilander\, Medicinaregatan 3 URL:https://www.scilifelab.se/event/scilifelab-metabolomics-platform-metabolomics-for-the-masses/ LOCATION:Birgit Thilander Lecture Hall\, Medicinaregatan 3\, Göteborg CATEGORIES:Event ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221214T153000 DTEND;TZID=Europe/Stockholm:20221214T170000 DTSTAMP:20260408T101312 CREATED:20221212T153057Z LAST-MODIFIED:20221212T153059Z UID:10000748-1671031800-1671037200@www.scilifelab.se SUMMARY:Chemical Biology Seminar Series DESCRIPTION:“TARGETING RIBOSOME BIOGENESIS IN CANCER” \n\n\n\nDimitris KanellisDept. of Medical Biochemistry and Biophysics\, Karolinska Institutet“SYNTHETIC SWITCHES FOR DNA REPAIR – CONTROLLING ENZYMATIC FUNCTIONS AT WILL”Maurice MichelDept. of Oncology-Pathology\, Karolinska Institutet \n\n\n\nDate: Wednesday December 14 \n\n\n\nTime: 3.30 pm \n\n\n\nLocation: Air & Fire\, SciLifeLab \n\n\n\nThe seminars are also available on Zoom. \n\n\n\n\nhttps://ki-se.zoom.us/j/66622023014 URL:https://www.scilifelab.se/event/chemical-biology-seminar-series/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221215T160000 DTEND;TZID=Europe/Stockholm:20221215T170000 DTSTAMP:20260408T101312 CREATED:20221212T155650Z LAST-MODIFIED:20221212T155652Z UID:10000749-1671120000-1671123600@www.scilifelab.se SUMMARY:Functional analysis of human protein phosphorylation sites DESCRIPTION:Matthias Selbach  \n\n\n\nPhosphoproteomics routinely quantifies changes in the levels of thousands of phosphorylation sites\, but functional analysis of such data remains a major challenge. I will present three different ways to characterise the function of human phosphorylation sites. First\, I will show how data from in vitro kinase assays can be used to predict kinase activity in phosphoproteomic datasets. Second\, I will show quantitative affinity purification experiments with synthetic phosphopeptides can help to assess their cellular function. Finally\, I will outline how quantitative RNA-interactome capture (qRIC) can quantify the fraction of cellular RNA-binding proteins that are pulled down with polyadenylated mRNAs. Combining qRIC with phosphoproteomics allows us to systematically compare pull-down efficiencies of phosphorylated and non-phosphorylated forms of RBPs. Using qRIC\, we identify over hundred phosphorylation sites with regulatory potential\, including known regulatory sites. Follow-up experiments on the cardiac splicing regulator RBM20 revealed that multiple phosphorylation sites in the C-terminal disordered region affect nucleo-cytoplasmic localisation\, association with cytosolic RNA granules and alternative splicing.      \n\n\n\nSelected publications\n\n\n\n\nVieira-Vieira\, CH\, Dauksaite\, V.\, Sporbert\, A.\, Gotthardt\, M. and Selbach M. (2022) Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20. Mol Cell 82\, 2069-2083.\n\n\n\nMeyer\, K.\, Kirchner\, M.\, Uyar\, B.\, Cheng\, J.Y.\, Russo\, G.\, …\, and Selbach\, M. (2018). Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs. Cell 175\, 239-253.\n\n\n\nImami\, K.\, Milek\, M.\, Bogdanow\, B.\, Yasuda\, T.\, Kastelic\, N.\, …\, and Selbach\, M. (2018). Mol Cell. Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis. Mol Cell 72\,\n\n\n\nZauber\, H.\, Kirchner\, M.\, and Selbach\, M. (2018). Picky: a simple online PRM and SRM method designer for targeted proteomics. Nat Methods 15\, 156-157.\n\n\n\nMcShane\, E.\, Sin\, C.\, Zauber\, H\, Wells JN\, Donnelly N\, …\, and Selbach M. (2016). Kinetic analysis of protein stability reveals age-dependent degradation. Cell 167\, 803-815.\n\n\n\nSchwanhausser\, B.\, Busse\, D.\, Li\, N.\, Dittmar\, G.\, Schuchhardt\, J.\, Wolf\, J.\, Chen\, W.\, and Selbach\, M. (2011). Global quantification of mammalian gene expression control. Nature 473\, 337-342. URL:https://www.scilifelab.se/event/functional-analysis-of-human-protein-phosphorylation-sites/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="Janne Lehti%C3%B6":MAILTO:janne.lehtio@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221216T090000 DTEND;TZID=Europe/Stockholm:20221216T093000 DTSTAMP:20260408T101312 CREATED:20220923T091314Z LAST-MODIFIED:20221201T124338Z UID:10000688-1671181200-1671183000@www.scilifelab.se SUMMARY:[Clinical Talks] Functional precision medicine using AI drug discovery DESCRIPTION:Greg Vladimer\n\n\n\nVice President\, Translational Research at Exscientia \n\n\n\n\n\n\n\nGreg Vladimer\, VP\, Translational Research joined Exscientia through the acquisition of Allcyte\, a pioneer in the field of AI-first functional precision oncology and translational cancer research\, where he was a Scientific Co-Founder and the Chief Scientific Officer. At Allcyte\, he and his team pushed the boundaries of translational cancer research through the use of disease relevant primary human cancer samples\, high content imaging\, custom AI-powered computer vision\, and scalable cloud computing. Greg has a PhD from University of Massachusetts Medical School in Immunology\, after which he moved to Vienna as an EMBO-supported Postdoctoral Fellow at CeMM where he and a colleague invented the first-generation platform used for the translational work\, and spearheaded the first ever prospective interventional clinical trial showing that drugs prioritised using a functional precision medicine tool had clinical benefit for late stage blood cancer patients. \n\n\n\nregister to receive zoom link\n\n\n\nModerator: Päivi Östling\, SciLifeLab \n\n\n\n\n\n\n\n \n\n\n\nClinical Talks\n\n\n\nClinical Talks is back for more! With a brand new and shiny Season 6. After successfully completing 5 seasons with > 70 enthusiastic Clinical Talkers to our record\, we have barely scratched the surface of all the amazing work our clinical\, academic and industry Life Science community has to offer. More about the upcoming events is available here. \n\n\n\nThese events are co-organized by Karolinska Institutet Innovations AB and SciLifeLab\, and brought to you by Colibri Ventures. URL:https://www.scilifelab.se/event/functional-precision-medicine-using-ai-drug-discovery/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/08/Square-500x500-Clinical-Talks@4x.png ORGANIZER;CN="Clinical Talks":MAILTO:precisionmedicine@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230110T090000 DTEND;TZID=Europe/Stockholm:20230112T170000 DTSTAMP:20260408T101312 CREATED:20221006T115605Z LAST-MODIFIED:20230109T152852Z UID:10000709-1673341200-1673542800@www.scilifelab.se SUMMARY:Evolution in Sweden 2023 DESCRIPTION:Evolution in Sweden is a biannual meeting\, which broadly gathers evolutionary biologists working in Sweden. The meeting was held in Uppsala 2014\, Lund 2016\, Stockholm 2018\, and Gothenburg 2020. The host for 2023 is Evolutionary Biology Centre\, at Uppsala University. The meeting is aimed to be a broad meeting on every aspect of evolutionary biology of all forms of life on Earth. However\, please note that the meeting is restricted to scientists active in Swedish academic departments. \n\n\n\nThis year the Evolution in Sweden conference is organized together with the Evolution and Biodiversity research area from the Data-driven life science program (DDLS)\, part of a 12-year SEK 3.1 billion initiative from the Knut and Alice Wallenberg Foundation. Please find more information about the DDLS program here. We encourage researchers working with analysis of large data sets in the fields of evolution and biodiversity to attend. \n\n\n\nKeynote speakers: \n\n\n\nLuis-Miguel Chevin\, Centre d’Ecologie Fonctionnelle et Evolutive\, CNRS Montpellier\, France\, Paul Hohenlohe\, University of Idaho\, USA and Tanja Schwander\, University of Lausanne\, Switzerland. \n\n\n\nRegistration: \n\n\n\nRegistration and check-in will open at 09:30 on Tuesday\, January 10\, followed by self-catered lunch. No registration fee\, fika will be provided. Lunch\, Dinner\, and Hotel are not included in the registration. \n\n\n\nPosters: \n\n\n\nWe ask you kindly to hang your poster during the registration\, pins will be provided. Make sure to stand by your poster at the Poster session. The poster board area is 119×89 (excl frame)\, in standing format. \n\n\n\nLunches: \n\n\n\nThe lunches will be self-catered. There is a restaurant at EBC\, Hassans\, and restaurants close by\, for instance\, Blåsenhus or Segerstedthuset (see Google maps). There will be pub evenings (at your own expense) and an informal dinner on January 11. \n\n\n\nInformal Conference dinner on January 11: \n\n\n\nThe registered participants have received a separate invitation to attend the informal dinner on January 11. Attendance is optional\, and the cost is the participant’s responsibility. A Lebanese buffet (195 kr not including beverages or coffee) will be offered at Hassans at EBC. Follow the instructions in the invitation to register\, and remember to pay the restaurant in advance using Swish. \n\n\n\nConference Pub and Hotel: \n\n\n\nThe Conference Pub\, on January 10\, is Bishop Arms. Keynote speakers are staying at the Elite Hotel Academia. We have not pre-negotiated any hotel rooms for the participants. \n\n\n\nConference book: \n\n\n\nA link to the Conference book is sent to all registered participants\, with a detailed program\, information about the keynote speakers\, abstracts\, and a List of participants. \n\n\n\nCancellation of attendance: \n\n\n\nemail events@SciLifeLab.se \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\n\n\n\n\nBrief program\n\n\n\nThe detailed program is published in the Conference Abstract book\, and emailed to all participants. \n\n\n\nJanuary 10\n\n\n\n09:3012:00On-site registration opens outside Friessalen and Ekmansalen\, EBC12:00Lunch (self-catered)12:45Welcome (parallel in Fries and Ekman)13:00Keynote: (parallel in Fries and Ekman)Adaptive capacity in wildlife populations: a case study of a unique diseasePaul A. Hohenlohe\, University of Idaho\, USA14:0017:00Two parallel afternoon sessions (Friessalen and Ekmansalen\, EBC) with coffee at 15:15-15:4518:00Conference pub; Bishop Arms (map)\n\n\n\nJanuary 11\n\n\n\n09:0012:00Two parallel morning sessions (Friessalen and Ekmansalen\, EBC) with coffee at 10:15-10:4512:00Lunch (self-catered)13:30Keynote: (parallel in Fries and Ekman)Evolution and consequences of parthenogenesis: Insights from stick insectsTanja Schwander\, University of Lausanne\, Switzerland14:3017:30Two parallel afternoon sessions (Friessalen and Ekmansalen\, EBC) with coffee at 15:45-16:1517:30Poster session\, cash bar on 2nd floor.19:15Dinner buffet at Hassans\, EBC (more information sent to the Conference participants)23:00EBC closes\, and everyone has to leave the Campus building for security reasons.\n\n\n\nJanuary 12\n\n\n\n09:0012:00Two parallel morning sessions incl. DDLS (Friessalen and Ekmansalen\, EBC) with coffee at 10:15-10:4512:00Lunch (self-catered)13:30Keynote: (parallel in Fries and Ekman)Predictability of ecology and evolution in randomly fluctuating environmentsLuis-Miguel Chevin\, Centre d’Ecologie Fonctionnelle et Evolutive\, CNRS Montpellier\, France14:30Final remarks\, future meeting thoughts15:00Meeting closesUpdated: December 12.\n\n\n\n\n\n\n\nPaul Hohenlohe\, Abstract and Bio\nAdaptive capacity in wildlife populations: a case study of a unique disease \n\n\n\nWildlife populations face threats from climate change\, invasive species\, habitat modification\, disease\, and other factors. Evolutionary biology and genomics provide powerful tools for assessing the capacity of populations to adapt and persist. As a case study for adaptive capacity\, I focus on a unique disease that threatens the persistence of Tasmanian devils. Devil facial tumor disease (DFTD) is a transmissible cancer that has spread across the species range. Using genomic techniques\, we have found evidence of rapid evolution in response to DFTD as well as a genetic basis for disease-related phenotypes. Recently a second independently derived transmissible cancer was discovered in devils\, raising the possibility that this is a recurrent selective force. We have found widespread evidence of both historical and contemporary selection in the devil genome\, but no evidence that genes currently responding to DFTD were under recurrent selection in the past. These results help us assess the capacity of devil populations to adapt to threats\, including transmissible cancers\, and can help guide the management of both wild and captive devil populations. \n\n\n\nBio \n\n\n\nPaul A. Hohenlohe is an Associate Professor of Biological Sciences at the University of Idaho\, USA. He earned his Ph.D. in Zoology from the University of Washington and worked as a conservation biologist for the U.S. federal government. During his postdoctoral work at the University of Oregon\, he was part of the team that developed RAD sequencing as a tool for population genomics. His current research program focuses on evolutionary genetics and genomics with applications to conservation of biodiversity\, across a wide range of plant and animal taxa. He is also the director of the Bioinformatics and Computational Biology graduate degree program at UI. \n\n\n\n\nTanja Schwander\, Abstract and Bio\nEvolution and consequences of parthenogenesis: Insights from stick insects \n\n\n\nParthenogenesis is predicted to have many evolutionary consequences\, since gamete production and the restoration of somatic ploidy levels via fertilization no longer take place\, and because male phenotypes are not exposed to selection. The empirical evidence for most predictions remains however scarce\, largely because in case studies of isolated parthenogenetic species\, putative effects of parthenogenesis are confounded with species specific patterns. To fill this knowledge gap\, we study independently evolved asexual arthropod species and their sexual relatives. I will discuss the insights we developed from genome andtranscriptome comparisons of sexual and asexual stick insect species as well from comparisons across new and previously published genomes of parthenogenetic animals. \n\n\n\nBio \n\n\n\nTanja Schwander earned her PhD at the University of Lausanne 2007 and then got postdoctoral and independent researcher fellowships at Simon Fraser University (CA)\, University of Groningen (NL) and the Wissenschaftskolleg zu Berlin (DE). Tanja returned to Lausanne with a SNSF starting grant in 2013 and got a tenure track position there in 2014. Since 2018\, Tanja is an associate professor at University of Lausanne. \n\n\n\n\nLuis-Miguel Chevin\, Abstract and Bio\nPredictability of ecology and evolution in randomly fluctuating environments \n\n\n\nMost natural environments exhibit some component of random variation or noise\, which can only be predicted in a probabilistic sense. Current anthropogenic change\, beyond causing trends in mean environments\, also modifies the patterns of these fluctuations\, so there is a need to better understand their influences on ecology and evolution. Population responses to environmental noise depend not only on the magnitude of fluctuations\, but also on their alternation pattern\, as captured by their temporal autocorrelation. However\, a major challenge when investigating these effects is that their inherent stochasticity requires abundant replication\, which is often unfeasible in nature. I will argue that a powerful strategy towards this goal is to use a combination of approaches: theory\, experimental evolution\, and analyses of natural populations. I will illustrate this by confronting results from our long-term experiments with the microalga Dunaliella salina under randomly fluctuating salinity to theoretical predictions about changes in population size\, genetic composition\, phenotypes\, and fitness. I will end by considering how ecological interactions\, within and between species\, may alter these population responses to randomly fluctuating environments. \n\n\n\nBio \n\n\n\nLuis-Miguel Chevin did his PhD at University Paris South (2005-2008) then a postdoc at Imperial College London in Silwood Park (2009-2011). Luis-Miguel was hired in 2011 as a permanent CNRS researcher at the Center for Functional and Evolutionary Ecology in Montpellier\, where he is now a CNRS research director. \n\n\n\n\nFor more information\, feel free to contact events@scilifelab.se or the organizers: \n\n\n\nScientific Committee\n\n\n\n\nArild Husby\, Evolutionary Biology Centre\, Uppsala University\n\n\n\nFrank Johansson\, Evolutionary Biology Centre\, Uppsala University\n\n\n\nPascal Milesi\, SciLifeLab\, Uppsala University\n\n\n\nAndreas Wallberg\, Biomedical Centre\, Uppsala University\n\n\n\nMatthew Webster\, Biomedical Centre\, Uppsala University\n\n\n\nTanja Slotte\, Stockholm University URL:https://www.scilifelab.se/event/evolution-in-sweden-2023/ LOCATION:Friessalen\, Evolutionsbiologiskt centrum\, EBC Norbyvägen 14-18\, Uppsala\, 752 36 CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/10/c_1020232-l_3-k_imagepuff.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230110T140000 DTEND;TZID=Europe/Stockholm:20230110T150000 DTSTAMP:20260408T101312 CREATED:20221201T082039Z LAST-MODIFIED:20221219T112300Z UID:10000744-1673359200-1673362800@www.scilifelab.se SUMMARY:User Experience (UX) Design to build intuitive web applications for life science research DESCRIPTION:This online webinar will showcase the basic User Experience (UX) Design principles with lessons learned from adopting them to build web applications in a life science research environment. The event is organised and hosted by NBIS and SciLifeLab with an invited speaker and Senior UX Designer from the European Bioinformatics Institute (EMBL-EBI). \n\n\n\nThe webinar aims to highlight some of the basic principles of User Experience (UX) Design\, to demonstrate how they provide value in the development process and to guide participants to resources for adopting UX Design practices in their own projects. While the intended audience is NBIS and SciLifeLab staff the registration is open to everyone interested in developing web applications and services for life science research. Registration is required to receive instructions and connection details for the event.  \n\n\n\nsign up here\n\n\n\nNikiforos Karamanis\, Senior UX Designer at the European Bioinformatics Institute (EMBL-EBI)\, describes his talk as follows: \n\n\n\n– In this talk I’ll present a case study which introduces the basic principles of UX Design and will hopefully inspire you to apply them to your own projects. I’ll outline the three iterative steps that the UX Design process consists of\, namely User Research\, Design and Feedback. In User Research we try to understand who our information or data is for and why these people need it. During the Design phase we explore different ways of helping our target users answer their questions. Feedback sessions with users help us figure out if our designs actually work. I’ll conclude the talk with the lessons that I learned from applying this process in a scientific setting and will share some resources to help you learn more about UX design. URL:https://www.scilifelab.se/event/user-experience-ux-design-to-build-intuitive-web-applications-for-life-science-research/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230111T110000 DTEND;TZID=Europe/Stockholm:20230111T114500 DTSTAMP:20260408T101312 CREATED:20221220T095206Z LAST-MODIFIED:20230109T155739Z UID:10000754-1673434800-1673437500@www.scilifelab.se SUMMARY:Call for new drug discovery pilot projects at SciLifeLab DDD with special emphasis on new modalities and antibiotics DESCRIPTION:Program\n\n\n\n\nInformation of new DDD call in Anubis – Per Arvidsson\n\n\n\n”Antibiotic research through DDD and Enable2” – Anders Karlén\n\n\n\n”New modalities as therapies of the future” – Per Arvidsson\n\n\n\n\nIn this call\, the Drug Discovery and Development Platform (DDD) at SciLifeLab is looking for new pilot project proposals for drug discovery. All therapeutic modalities are of interest. Of special interest are new project ideas for new modalities including therapeutic oligonucleotides\, and in collaboration with ENABLE2 https://www.ilk.uu.se/enable2/\, projects for discovery of new antibiotics. \n\n\n\nNote that shorter projects for selections in phage display libraries for antibodies and in DNA encoded chemical libraries for small molecules can be considered.A description of new modalities in drug discovery research can be found here: https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00582 \n\n\n\nProgram\n\n\n\n11.00 Introduction to Anubis call for DDD pilot-projects\, Kristian Sandberg \n\n\n\n11.05 Antibiotic drug discovery through ENABLE2 and DDD\, Anders Karlén \n\n\n\n11.15 Oligonucleotide therapeutics through OligoNova HUB at DDD\, Pär Matsson \n\n\n\n11.25 New therapeutic modalities and selection in enormous antibody and small molecule libraries\, Per Arvidsson \n\n\n\n11.40 Questions & Answers\, Moderated by Kristian Sandberg \n\n\n\nIf you have questions about the call please contact DDD by email (dddprojectproposal@scilifelab.se). This call is open for scientists with a doctoral degree at a Swedish university or higher institution. English should be used when filling out this application. You are responsible for ensuring that the application is complete. Incomplete applications will not be processed. \n\n\n\nMore about the call\n\n\n\nRegistration to the Event URL:https://www.scilifelab.se/event/call-for-new-drug-discovery-pilot-projects-at-scilifelab-ddd-with-special-emphasis-on-new-modalities-and-antibiotics/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230118T151500 DTEND;TZID=Europe/Stockholm:20230118T161500 DTSTAMP:20260408T101312 CREATED:20230108T194843Z LAST-MODIFIED:20230110T091905Z UID:10000781-1674054900-1674058500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - High-throughput biology at the organismal level DESCRIPTION:Jan 18\, at 15:15 in BMC\, C8:301 \n\n\n\nProf. Randall Peterson\,Dean\, College of PharmacyDepartment of Pharmacology and Toxicology\, University of Utah\, USA \n\n\n\nBio\n\n\n\nRandall T. Peterson\, PhD is a chemical biologist whose research utilizes high-throughput screening technologies to discover new drug candidates for cardiovascular and nervous system disorders. Unlike conventional drug discovery programs that utilize simplified\, in vitro assays\, the Peterson lab screens using living zebrafish\, ensuring that the drug candidates discovered are active in vivo. Several of the compounds discovered by the Peterson laboratory have become widely used research tools or preclinical drug candidates.Dr. Peterson received his PhD from Harvard University where he studied as a Howard Hughes Medical Institute predoctoral fellow in the laboratory of Stuart Schreiber.  He completed a postdoctoral fellowship with Mark Fishman at Massachusetts General Hospital. Dr. Peterson spent 14 years as a faculty member at Harvard University where he was the Charles Addison and Elizabeth Ann Sanders Chair in Basic Science at Harvard Medical School\, Scientific Director of the MGH Cardiovascular Research Center\, and Senior Associate Member of the Broad Institute.  In 2017 he moved to the University of Utah as L.S. Skaggs Presidential Endowed Professor and Dean of the College of Pharmacy. \n\n\n\nTitle of the talk: High-throughput biology at the organismal level\n\n\n\nThe impact of high-throughput technologies on biological research has been remarkable. For example\, high-throughput drug screens have revolutionized drug discovery\, and high-throughput CRISPR screens are revolutionizing gene discovery. Notably\, these techniques have focused almost entirely on simple\, in vitro or cell-based assays\, leaving untouched organismal processes such as embryonic development\, physiology\, and animal behavior. These organismal processes are best studied in vivo\, and consequently have not been amenable to high-throughput biology. The Peterson lab is focused on applying high-throughput technologies to such organismal processes and is developing methodologies that enable CRISPR screens and small molecule screens to be applied to organismal processes in zebrafish. Recently\, we have discovered small molecules and genes with novel activities on the cardiovascular\, nervous\, and endocrine systems. I will describe how the compounds and genes were discovered\, what they have taught us about biology\, and how they might find practical or clinical utility. \n\n\n\nHost: Marcel den Hoed marcel.den_hoed@igp.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-randall-peterson-prof/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230119T080000 DTEND;TZID=Europe/Stockholm:20230119T170000 DTSTAMP:20260408T101312 CREATED:20221209T130532Z LAST-MODIFIED:20221213T124743Z UID:10000746-1674115200-1674147600@www.scilifelab.se SUMMARY:Uppsala University Pharmaceutical Profiling in Drug Discovery and Development Symposium DESCRIPTION:Every year\, the Drug Delivery group at the Department of Pharmacy (headed by Prof. Per Artursson\, Prof. Christel Bergström and Dr. Pawel Baranczewski) organizes a one-day symposium on pharmaceutical profiling. On January 19th\, 2023\, the 12th Uppsala University Pharmaceutical Profiling in Drug Discovery and Development Symposium will be arranged.  \n\n\n\nregistration\n\n\n\nThis twelfth edition of the symposium will focus on new modalities with respect to their development and formulation to overcome biological barriers and achieve targeted therapies. Past symposia have been highly attended by faculty and students at Uppsala University and other Swedish and international universities\, as well as by researchers from the local biotech and pharma industry and from regulatory agencies. \n\n\n\nPrevious keynote speakers included among others Prof. Langer (MIT)\, Prof. Alonso (USC CIMUS Research Institute)\, Prof. Porter (Monash University)\, Prof. Leroux (ETH Zürich) and Dr. Hochman (Merck). The symposia provide excellent opportunities for academia-industry networking and for scientific discussions on current research at our platform for drug optimization and pharmaceutical profiling as well as in the Drug Delivery research group at the Department of Pharmacy. \n\n\n\nThis year’s confirmed speakers and the titles of their talks: \n\n\n\n\nProf. Olivia Merkel (Ludwig-Maximilians-Universität München\, Germany): Treatment of lung diseases via siRNA inhalation delivery \n\n\n\nProf. Paola Luciani (University of Bern\, Switzerland): Targeting fibrosis in multiple organs via lipid-based drug delivery systems \n\n\n\nProf. Ola Söderberg (Uppsala University\, Sweden): Development of novel molecular biology tools for medical research \n\n\n\nAssist. Prof. Daniel Fürth (Uppsala University\, Sweden): A chemoselective in vivo sequencing chemistry \n\n\n\nProf. Yvonne Perrie (University of Strathclyde\, Scotland): Formulation strategies for the delivery of mRNA vaccines \n\n\n\nProf. My Hedhammar (KTH Royal Institute of Technology/Spiber Technologies AB\, Sweden): FN-silk membrane as mimic of basement membrane in tissue barrier models \n\n\n\nAssoc. Prof. Daniel Espes (Uppsala University\, Sweden): Novel imaging techniques and drugs for targeting human pancreatic islets \n\n\n\nProf. Per I Arvidsson (Karolinska Institutet\, Sweden): Explorations and innovations at the academia-industry interface – tales from the SciLifeLab DDD infrastructure \n\n\n\nProf. Jens Carlsson (Uppsala University\, Sweden): Antiviral drug discovery by virtual screening of ultra-large chemical libraries \n\n\n\n\nThere will also be a panel discussion about “Impact of European drug delivery science”\, led by Dr. Björn Arvidsson. \n\n\n\nOrganizers: \n\n\n\n\nDrug Delivery group\, Uppsala University\n\n\n\nSciLifeLab\n\n\n\nUDOPP URL:https://www.scilifelab.se/event/uppsala-university-pharmaceutical-profiling-in-drug-discovery-and-development-symposium/ LOCATION:Humanities Theater\, Engelska parken\, Uppsala\, 75238\, Sweden CATEGORIES:Event END:VEVENT END:VCALENDAR