SwedNMR Meeting: Unravelling BioSolids mysteries by novel NMR approaches
2025-11-17 12:00 - 2025-11-18 09:00 (Europe/Stockholm) | Stora Fokusrummet, KBC, Linnaeus väg 6, Umeå, 90736, Sweden
Join us on the 17th and 18th of November, the SwedNMR and its Umeå node will host a meeting were the current achievements will be highlighted and there will be a discussion in future directions in method development and new application areas

SwedNMR offers state-of-the-art NMR infrastructure and expertise to study a wide range of biosolids with atomic-level insight, including crystalline materials, drugs, biomembranes, protein aggregates, as well as plant and medical biopsies. SwedNMR via its Umeå node is the first word-wide to offer both ultra-fast solid-state MAS NMR and CryoMAS-NMR solid-state providing a new dimension in structural information and sensitivity for bioSolids. Together with the DNP facility at the NMR Centre in Gothenburg, SwedNMR provides world-wide unique structural and dynamic insights into complex biological solids and tiny intact biospecimens.

Registration

Registration

Sign up for the SwedNMR Meeting: Unravelling BioSolids mysteries by novel NMR approaches, a two day meeting starting on Monday the 17th of November at 12 pm

In the registration you can find more information about the program

If you have any further questions you can contact:

Ilona Dudka, ilona.dudka@umu.se

Gerhard Gröbner, gerhard.grobner@umu.se

Tobias Sparrman, tobias.sparrman@umu.se

[The Svedberg seminar] - Coagulation: Cancer's new best friend
2025-11-17 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Gareth Owen

Professor Pontificia Universidad Católica de Chile, Chile

Bio

Dr. Gareth Owen is currently visiting Professor in the lab of Dr Masood Kamali-Moghaddam, Department of Immunology, Genetics and Pathology, Uppsala University. He is a full professor in the Faculty of Biological Sciences and Faculty of Medicine at the Pontificia Universidad Catolica de Chile. Dr Owen did his BSc at King’s College London and has a PhD from the Royal Postgraduate Medical School, Hammersmith Hospital, London UK (Imperial College London). This was followed by a post-doctoral fellowships at the University of Colorado USA, and the Institute of Cancer Research (ICR-UK). Dr Owen is a PI in the Millennium Institute on Immunology and Immunotherapy Chile, and Board member of the Chilean National Cancer Forum.

Coagulation: Cancer’s new best friend

Coagulation is linked to cancer progression, with many patients exhibiting chronic hypercoagulability. Anticoagulant therapy has been associated with improved outcomes. Beyond hemostasis, the coagulation system can drive inflammation and metastasis, though the mechanisms remain unclear. Herein, we demonstrate that elevated levels of activated coagulation factor X (FXa) increase lung metastasis and that FXa promotes an immunosuppressive tumor microenvironment. Using a murine model of melanoma and in vitro assays, we found that FXa increased infiltration of regulatory T cells and Th17 cells, and upregulated PD-1 and CTLA-4 expression on CD4+ and CD8+ T cells. Co-treatment with the anti-FXa anticoagulant dalteparin abrogated these effects. Mechanistically, FXa in vitro suppressed macrophage M1 and Th1 differentiation through the Protease-Activated Receptor-1 (PAR1). The clinically approved PAR1 inhibitor Vorapaxar blocked FXa-induced tumor progression in vivo. These findings identify FXa or PAR1 inhibition as therapeutic strategies in cancer therapy.

Host: Masood Kamali-Moghaddam masood.kamali@igp.uu.se, UU

Powering Proteomics: Technologies, Insights, and Clinical Applications
2025-11-20 13:00 - 15:30
Join us for an engaging workshop on proteomics, exploring cutting-edge approaches in mass spectrometry and affinity-based methods. The event will feature external researchers sharing the latest developments and applications in protein analysis. Participants will gain insights into experimental strategies and see real-world examples highlighting how proteomics advances biomedical research and biomarker discovery.

Registration

Registration

You can join the Zoom meeting via the Confirmation email.

Program

Workshop on proteomicsDownload

13:00-13:05 Welcome

13:05-13:30 “Using mass spectrometry to characterize the airway proteome and treatment responses in cystic fibrosis”.

Presenter: Lisa Påhlman, Lund University

Host: Anahita Bakochi, Clinical Proteomics, Lund University

13:30-13:55 “Low Cell Proteomics resolves oncogenic molecular mechanisms in rare cell types”

Presenter: Pedro Moura, Karolinska Institute

Host: Henrik Johansson, Global Proteomics & proteogenomics, Karolinska Institute

13:55-14:20 “Applications of Proteomics in Steatotic Liver Disease”

Presenter: Tanmoy Dutta, Gothenburg University

Host: Carina Sihlbom Wallem, Glycoproteomics & MS Proteomics, Gothenburg University

14:20-14:45 “Shared and specific blood biomarkers for multimorbidity”

Presenter: Davide Liborio Vetrano, Karolinska Institute

Host: Claudia Fredolini, Affinity Proteomics-Stockholm, Royal Institute of Technology-KTH

14:45-15:10 “The circulating blood proteome of childhood acute leukemia”

Presenter Jessica Nordlund, Uppsala University

Host: Mikael Åberg, Affinity Proteomics Uppsala, Uppsala University

15:10:15:30 Questions and Final Remarks

Rapid traversal of vast chemical space using machine learning-guided docking screens to accelerate drug discovery
2025-11-21 10:00 - 11:00 | Online event via Zoom
Speaker: Israel Cabeza de Vaca, Uppsala university (Jens Carlsson group).

NBIS and SciLifeLab Data Centre arrange an open SciLifeLab AI Seminar Series aimed at knowledge-sharing about Artificial Intelligence and applications in the Life Science community. The seminar series is open to everyone. The seminar is run over Zoom on the third Friday of the month during academic terms, typically between 10 and 11 am, with approx. 45 min presentation and 15 min discussion.

AbstractThe rapid expansion of make-on-demand chemical libraries now offers access to tens of billions of synthetically accessible molecules, creating unprecedented opportunities for structure-based drug discovery. However, screening such ultra-large libraries remains computationally prohibitive, even with state-of-the-art docking methods.In this presentation, I will describe a hybrid virtual screening strategy that integrates molecular docking with machine learning to efficiently navigate chemical space at the billion-compound scale. The workflow involves docking approximately one million compounds to a target protein and training a classification model to recognize high-scoring molecules. Using conformal prediction, the model guides compound selection from multi-billion-scale libraries, drastically reducing the number of molecules requiring explicit docking.Among several algorithms evaluated, CatBoost provided the best balance between accuracy and computational efficiency, enabling large-scale applications. When applied to a 3.5-billion-compound library, this approach reduced the computational cost of virtual screening by over three orders of magnitude. Experimental validation identified novel ligands for multiple G protein–coupled receptors, including compounds exhibiting designed multi-target activity.These results demonstrate how combining AI-based prediction with physics-based docking can make ultra-large-scale virtual screening a practical and powerful tool for modern drug discovery.

ContactFor questions, contact bengt.sennblad@scilifelab.se

zoom link

FAIR play: Mastering Metadata to Empower Life Scientists
2025-11-25 11:00 - 12:00 | https://uu-se.zoom.us/j/62780940554?from=addon
Unlock the potential of your research by mastering meta(data) management in and the FAIR Data Principles—Findable, Accessible, Interoperable, and Reusable. This session offers practical guidance tailored for life scientists, focusing on best practices to organise and share your data effectively. The talk will focus on how good metadata practices can enhance collaboration, ensure reproducibility, and align your work with Open Science principles, ultimately increasing the impact of your research.

Presenter: Parul Tewatia, PhD, project coordinator (FAIR metadata and semantic technologies), SciLifeLab Data Centre

Recording: https://youtu.be/mc4BOOoLTMASlides: https://doi.org/10.17044/scilifelab.28615511

More information

This event is part of the SciLifeLab Open Science seminar series, an event series by the SciLifeLab Data Centre and NBIS joint Data Management team.The goal of the events in this seminar series is to provide interesting interactive seminars around topics related to Research Data Management and Open Science in general, and to foster discussions around best practices.

Research Data Management (RDM) concerns the organization, storage, preservation, and sharing of data that is collected and analyzed during a research project. Proper planning and management of research data will make project management easier and more efficient while projects are being performed. It also facilitates sharing and allows others to validate as well as reuse the data.Open Science is a set of principles and practices that aim to make scientific research from all fields accessible to everyone for the benefits of scientists and society as a whole. Open science is about making sure not only that scientific knowledge is accessible but also that the production of that knowledge itself is inclusive, equitable and sustainable.

The events are open to everyone working at or affiliated with a Swedish research institute or university. We welcome all researchers, educational professionals, staff, RDM professionals, and others with an interest in life sciences, from all university levels. The events are informal and inclusive, so feel welcome to join and participate in our interesting discussions!

The events will be recorded and published openly after the seminars on the SciLifeLab YouTube channel. The slides will be made available at our SciLifeLab Data Repository. More information about SciLifeLab Data Centre and NBIS joint Open Science seminar series: https://www.scilifelab.se/data/scilifelab-data-management-seminar-series/

If you have suggestions for topics or presentations, please contact us at data-management@scilifelab.seFor more information or inquiries, please contact us at data-management@scilifelab.se

[Spotlight Seminar Series] Molecular Mechanisms Underlying the Energy Currents of Life
2025-11-25 15:15 - 16:30 | Gamma 2 Lunchroom, SciLifeLab, Tomtebodavägen 23, Solna, Sweden
Spotlight seminar series proudly welcomes Professor Vile R. I. Kaila to give a seminar at SciLifeLab Campus Solna.

Biography

Ville R. I. Kaila received his PhD in biochemistry in 2009 from University of Helsinki. After a postdoc at the US National Institutes of Health (NIH), he was appointed a professorship at the Technical University of Munich in 2013. In 2019, Kaila moved with his research group to Stockholm, where he is currently professor at the Department of Biochemistry and Biophysics at Stockholm University and a Wallenberg Scholar. His research focuses on elucidating mechanistic principles of bioenergetic enzyme complexes by development of integrative computational and experimental approaches. Read more at http://villekaila.com/

Abstract

Biological energy conversion is catalyzed by intricate protein complexes that transduce redox energy into proton currents across a biological membrane, powering the cellular energy metabolism. Yet, despite significant advances in recent years, the molecular principles of these reactions remain poorly understood and pose major scientific challenges. In this talk, I describe our integrative mechanistic exploration of complex bioenergetic machines, where we combine multiscale simulations and data-driven methods with biophysical experiments and structural (cryo-EM) studies to derive a molecular understanding of intricate long-range charge transfer reactions in biology on a broad range of timescales and spatial resolutions. I describe our recent work on understanding enzymes catalyzing long-range charge transfer reaction by intrinsic electric field effects. We find that mutations of key residues mediating these allosteric processes lead to perturbed coupling effects, and development of severe human diseases, with striking similarities in different biological systems.

Host: Marta Carroni marta.carroni@scilifelab.se

NanoSIMS webinar series: Chemical bio-imaging using ToF-SIMS and OrbiSIMS
2025-11-26 15:00 - 16:00
This month’s Mass Spectrometry Imaging webinar will focus on chemical bio-imaging using ToF-SIMS and OrbiSIMS, what it is and where it is located, presented by Prof. David J. Scurr, the University of Nottingham, UK.

🕒 Time: 15:00–16:00 (presentation and discussion)☕ Followed by: Informal discussion with the speaker, 16:00–16:30📍 Format: Zoom

Zoom link

Meeting ID: 616 3655 5280Passcode: [REDACTED]

Speaker

Prof. David J. Scurr is a Principal Research Fellow at The University of Nottingham. He has pioneered the application of ToF-SIMS and OrbiSIMS in the field of pharmacy and biology. He obtained a BSc in Materials Science (2002) and PhD focusing upon materials characterisation (2005) at The University of Manchester. David’s research has a focus upon the implantation of novel data processing strategies, such as molecular formula prediction (MFP) [Edney et al. Anal. Chem. 2022].

His research highlights include the characterisation of biological samples using ToF-SIMS and OrbiSIMS, for example, breakthrough research into the in situ analysis of unlabelled proteins [Kotowska et al. Nature Comms, 2020] forming the basis of novel research in the development of proteomics / metabolomics, diseased tissue analysis and biomaterials at The University of Nottingham. Additionally, David’s research has demonstrated the ability of SIMS to characterise skin tissue and understand permeation mechanisms of xenobiotic chemistries (pharmaceutical, cosmetic, agrochemical and antibacterial) within complex tissues such as skin [Starr et al. PNAS, 2022].

Multimodal explorative testing in the ON-OFF ibrutinib trial in CLL
2025-11-28 09:00 - 09:30 | Online event via Zoom
Multimodal explorative testing in the ON-OFF ibrutinib trial in CLLRichard Rosenquist Brandell, Karolinska Institutet & Karolinska University Hospital

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western World and displays substantial variability in clinical course, ranging from indolent disease requiring no therapy to highly aggressive forms with short survival despite treatment. Although the past decade has seen major advances in drug development, CLL remains incurable. Targeted therapies, particularly Bruton’s tyrosine kinase inhibitors (BTKi), have become central to CLL management. However, continuous long-term BTKi administration, such as with ibrutinib, is associated with considerable significant side-effects, including cardiac arrhythmias. Furthermore, despite its proven efficacy in both treatment-naïve and relapsed/refractory CLL, resistance to ibrutinib continues to challenge durable disease control. To address these limitations, we conducted a phase 1b/2 prospective, single-arm, multicenter study evaluating controlled treatment cessation as a strategy to preserve tolerability and maintain sensitivity to ibrutinib, while also improving cost-effectiveness. The study protocol incorporated serial blood sampling prior to treatment initiation and throughout on/off treatment periods. Here, we leverage this unique longitudinal sample collection to perform multimodal profiling, including genomic and transcriptomic sequencing as well as proteomics, to investigate mechanisms of drug response and resistance. We provide an update on the current status of the study and ongoing analyses.

registration

Biography

Richard Rosenquist Brandell is Professor of Clinical Genetics at the Department of Molecular Medicine and Surgery, Karolinska Institutet, and Senior Physician in Clinical Genetics at Karolinska University Hospital, Sweden. Focusing on hematological malignancies and utilizing high-throughput sequencing and other innovative technologies, his research team has identified novel prognostic and predictive biomarkers that have refined disease classification and significantly improved patient risk-stratification and clinical decision-making. Richard Rosenquist Brandell initiated and led the Clinical Genomics Unit within Science for Life Laboratory (SciLifeLab) in Uppsala (2013-2017) and was platform director for the Clinical Genomics platform (2016-2021) within SciLifeLab, which includes seven Clinical Genomics units across Sweden. He is currently Director of Genomic Medicine Sweden (GMS), a national infrastructure for implementation of precision medicine. Rosenquist Brandell is a member of the Nobel Assembly at Karolinska Institutet.

[The Svedberg seminar] - Genome organisation and patterns of molecular evolution
2025-12-01 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Jennifer James

Assistant Professor DDLS Fellow

Bio

Dr. Jennifer James did her PhD in population genetics with Adam Eyre-Walker at the University of Sussex. After a postdoctoral position at the University of Cambridge she moved to the US, where she worked as a postdoctoral researcher with Joanna Masel at the University of Arizona, which introduced her to the world of proteomics. She next moved to Uppsala and worked as a postdoctoral research fellow with Martin Lascoux prior to becoming a DDLS fellow and starting her own new research group in Molecular Evolution. Her group conducts research on patterns of molecular evolution both at the genome and proteome level, with a focus on understanding mutational robustness.

Genome organisation and patterns of molecular evolution

In my group, we try to understand patterns of phenotypic evolution at the proteome level, and molecular evolution across the genome. Key to this question is understanding how the genome is structured and organised. For example, how pleiotropic are the effects of genes on average, and how complex are gene networks? To give one case, if pleiotropy is universal, such that all genes affect all traits, we expect all new mutations to have the same effect on fitness. However, the extent of pleiotropy in real biological systems remains debated. In this seminar I will discuss our

Host: Siv Andersson siv.andersson@icm.uu.se, UU

Introduction to the Module System on Berzelius
2025-12-02 10:00 - 11:30 | Zoom
This training offers a practical introduction to the module system on Berzelius. The session will cover:

how to find modules on Berzelius

load/unload modules

use modules in interactive or batch modes

create your own module

Participants will also gain hands-on experience with these commands. By the end of the session, you will be able to navigate the modules system Berzelius confidently and use them effectively for your research.-on experience with these commands. By the end of the session, you will be able to navigate Berzelius confidently and use its resources effectively for your research.

Date: December 2, 2025Time: 10:00–11:30

Target audience: The online event is open for all current and prospective Berzelius users. Please read the eligibility requirements for accessing Berzelius.Place: Online via Zoom (link provided upon registration)

registration

Preliminary Agenda

TimeSession TitleSpeaker(s)10:00–11:00Introduction to the Module System on BerzeliusSoumi Chaki11:00–11:30Open Q&A SessionBerzelius Application Expert

This event is a collaboration between National Supercomputer Centre (NSC) at Linköping University and SciLifeLab Data Centre.

For questions please contact soumi.chaki@liu.se (Soumi Chaki)

Is high-throughput electrophysiology possible?
2025-12-02 13:00 - 14:00
Register here

On site seminar – Electrophysiology Infrastructure

Location: Jörgen Lehmann, Academicum, Medicinaregatan 3 and SciLifeLab Gothenburg

Presenters

Fredrik Elinder, Professor, Site director SciLifeLab Linköping, Chemical Biology Consortium Sweden (CBCS), and Department of Biomedical and Clinical Sciences (BKV), Linköping University

Nina Ottosson, Research Coordinator, Chemical Biology Consortium Sweden (CBCS), and Department of Biomedical and Clinical Sciences (BKV), Linköping University

The electrophysiology unit at Linköping University, part of Chemical Biology Consortium Sweden (CBCS) at SciLifeLab, visits site Gothenburg, and presents the infrastructure during a seminar.

During the day, 1-on-1 meetings with the presenters will be possible at The SciLifeLab office, Medicinaregatan 3. Take the chance to discuss how your research questions can be answered through analyses of ion channels. Request is added in the registration form.

The electrophysiology unit, a recent addition to SciLifeLab’s range of infrastructures, is equipped with automated patch-clamp instrumentation, and supports a wide range of electrophysiological studies involving both voltage-gated and ligand-gated ion channels, including pharmacological screening, cardiac safety assessments, and biophysical investigations.

WELCOME!

Fredrik Elinder and Nina Ottosson, Electrophysiologists

Josefine Sandström and Maria Smedh, SciLifeLab site coordinators Webpage of the CBCS Linköping node.

User meeting for your multi-modal research projects
2025-12-04 09:00 - 10:30 | virtual event
Boost your research — Book a private SciLifeLab planning and feedback session for your multi-modal research projects!

Register here

Once we have received your registration, you will be sent the link to the online meeting.

Date: December 4, 9.00 – 10.30 Registration deadline: November 28

Multimodal molecular profiling and novel computational methods are transforming life science research, but also pose new challenges in study design, project resource planning and data management. SciLifeLab is a national resource of unique technologies and expertise available to life scientists, in areas such as biomedicine, ecology and evolution, aiming to bring scientists together across traditional boundaries and foster collaborations with industry, health care, public research organizations and international partners.

The first Thursday of every month at 9.00 (except July and August), SciLifeLab offers an opportunity to jointly meet with representatives across the SciLifeLab service platforms, to get feedback and help to plan, design, and refine new or ongoing multimodal research projects. Your project plans are discussed privately and remain confidential, and information will not be shared outside of the service platforms. Note that for most studies, follow-up meetings will be needed, but our aim for these meetings is to provide an easy-access entry point for an overarching planning of multimodal studies.

For studies focusing on a single technology only, please primarily contact our service platforms directly as described at the SciLifeLab homepage.

To make the best out of the allotted time, we ask you to provide some background information about your project, to help us ensure that the relevant experts are available to discuss your study.

3D Imaging in Health and Disease
2025-12-04 09:00 - 17:00 | Nobel Forum, Nobels väg 1, Solna, Sweden
Characterizing molecular and cellular complexities in 3D is an emerging field allowing to study biology in its true context.

In this symposium national and international experts will present developments and applications in 3D imaging aimed to improve health and disease analysis across scales

Please register by sending an e-mail to hans.blom@scilifelb.se

Program 3D symposiumDownload

Discovery and developmentof GRK2-biased beta 2-adrenergic receptor agonists for the treatment of metabolic disorders
2025-12-05 10:15 - 11:00 | BMC Room C4:301, Husargatan 3, entrance C1, Uppsala, Sweden
Presenter: Dr Benjamin Pelcman, Atrogi AB

Atrogi AB is biotech company pioneering first-in-class treatments to revolutionize metabolic health. The talk will describe how targeting a novel GRK-biased b2-adrenergic receptor signaling pathway allows for the successful design of compounds useful in the treatment of disorders like type 2 diabetes (T2D), obesity and muscular wasting. The approach will be exemplified by the invention, selection and development of ATR-258, a b2-AR agonist that was developed for T2D and is about to enter phase 2 clinical trials. During the exploration of the chemical space, a diverse set of molecules were synthesized, and their effect on the downstream signaling will be discussed. In addition, the seminar will illustrate differences between drug development in Big Pharma and small biotech and the challenges of working in an environment with limited resources.

After receiving his Ph.D. in Organic Chemistry at KTH and a post doc session at Dartmouth College, NH, USA, Benjamin joined Astra Pain Control, first in Södertälje and then in Montreal, as a medicinal chemist. Benjamin has also held various positions at Pharmacia & Upjohn, Karo Bio, Biolipox and Orexo. After having started his own consultancy company, BeePCo, he came in contact with Atrogi where he was employed first as a CEO and later as Head of Chemistry and IP. Benjamin is now retired but is still working as a consultant for Atrogi and other small biotechs.

[The Svedberg seminar] - The origins of locally adaptive loci
2025-12-08 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Gabriela Montejo-Kovacevich

Assistant Professor SciLifeLab Fellow Uppsala University

Bio

Gabriela Montejo-Kovacevich is a SciLifeLab fellow and Assistant Professor that recently established her lab at the Animal Ecology program in the Department of Ecology and Genetics at EBC (Uppsala University). Her group studies mechanisms that promote or constrain local adaptation. By integrating genomics with ecological and natural history approaches, mainly in insects, they explore the mode and tempo of evolution in natural populations.

The origins of locally adaptive lociHow do organisms evolve to inhabit diverse environments? This seminar explores the mode and tempo of evolution in the wild by studying local adaptation in three insect systems. I will first present work on Heliconius butterflies along a 1500m altitudinal gradient in the Andes, revealing strong, repeated selection at high-altitude, with evidence for adaptive introgression from pre-adapted species. I will then turn to a ‘megapest’ moth (Helicoverpa) that is threatening food security in Brazil through bidirectional adaptive introgression conferring insecticide resistance. Finally, I will introduce Euphydryas editha, a Californian butterfly capable of rapid, heritable shifts in host plant use offering a rare glimpse into ongoing behavioural adaptation to anthropogenic change. Together, these systems demonstrate how evolutionary forces interact to shape resilience in a rapidly changing world.

Host: Göran Arnqvist Goran.Arnqvist@ebc.uu.se, UU

Teaching and training as "communication": leveraging cognitive and communication theories to strengthen learning
2025-12-10 10:00 - 12:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Invited speaker: Professor Rochelle E. Tractenberg, Georgetown University

SciLifeLab as a Research Infrastructure incorporates people across a variety of technically complex fields. Staff-scientists and researchers often need to communicate about their complex work to people who are not fully familiar with all the details. Swedish universities offer training or support for scientists to help them communicate complex ideas for the public. However, we don’t often consider that these communication theories and strategies might be equally useful for promoting or strengthening a learning culture across the organization or that such communication strategies are useful in the training and teaching staff-scientists and researchers are involved in. This talk by Professor Tractenberg from Georgetown University will outline two theories – one for communication and one for change management – which have been augmented with cognitive theories so that they can optimize teaching and training and with this strengthen learning.

Welcome to a seminar where Professor Rochelle Tractenberg will present her recent work combining communication with change management strategies. We will learn how we can more efficiently can promote change around complex information – such as encouraging researchers to utilize a new method or tool, or instructing students about a complex aspect of the field they’re studying.

For registrants wishing to participate online, please indicate this in the registration form. For people attending onsite there will be a light lunch provided after the seminar.

Register here

Scientific abstract

Tractenberg’s augmented Diffusion of Innovation (aDOI, Tractenberg, 2023) is a theoretical framework for understanding and leveraging the cognitive complexity of messages so as to optimize uptake of the new information by any hearer. aDOI is adapted, through cognitive theory, from Rogers’ DOI communication model (1965/2003). A concrete, stepwise theory of change management (ToCM, Kotter 2012) originated in business, and has been widely used across business and leadership programs. This theory has also been augmented with cognitive theory (aToCM, Tractenberg 2024). Together, these two revised models provide a strategy for promoting change around complex information – such as encouraging scientists to utilize a new method or tool, or educating students about a complex aspect of the field they’re studying. Tractenberg’s augmented Diffusion of Innovation and Theory of Change Management make encouraging uptake of new ideas, or new knowledge, more consistent with human reasoning. These can support instructors’ adaptation of existing courses to include new information/technology or techniques, and can also help instructors to learn new evidence-based methods of teaching and assessing.

Science & SciLifeLab Prize Scientific Symposium 2025
2025-12-11 13:00 - 16:00 | Auditorium Stockholm, Grand Hôtel, Södra Blasieholmshamnen 8, Stockholm, 10327, Sweden
Welcome to the Scientific Symposium where the winners of the 2025 Science & SciLifeLab Prize for Young Scientists will present their research!

Science, the American Association for the Advancement of Science (AAAS), and SciLifeLab joined forces in 2013, creating the Science & SciLifeLab Prize for Young Scientists to recognize excellence amongst young researchers from around the world. A global Prize aimed at rewarding scientists at an early stage of their careers.

The Prize is awarded in four different categories and the winners will be announced on November 14th

Uche Medoh, Grand Prize Winner in Molecular Medicine

Liam Lachs, Category Winner in Ecology and Environment

Nitzan Tal, Category Winner in Genomics, Proteomics, and Systems Biology Approaches

King L. Hung, Category Winner in Cell and Molecular Biology

All four winners of the Science & SciLifeLab Prize for Young Scientists are invited to Sweden December 8-13 to participate in a unique week filled with events in honor of science. They will have the opportunity to meet with leading scientists in their field of research and create life-long connections to support their careers.

The symposium will take place at beautiful Grand Hôtel in Stockholm.

Seats are limited so register today for your chance to meet with the winners and the the AAAS/Science editor team AND our honorary guest, the Grand Prize Winner from 2024, Andrija Sente.

Registration

Program

Science SciLifeLab Prize SymposiumDownload

Read more about the Prize

Read more about the winners

[The Svedberg seminar] - Optogenetic control of gene expression dynamics in single cells
2025-12-15 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Mary Dunlop

Professor Boston University, USA

Bio

Mary Dunlop is a Professor of Biomedical Engineering and Dorf-Ebner Distinguished Faculty Fellow at Boston University. She holds additional affiliations in Bioinformatics and Molecular Biology, Cell Biology & Biochemistry. She graduated from Princeton University with a B.S.E. in Mechanical and Aerospace Engineering and a minor in Computer Science. She then received her M.S. and Ph.D. in Mechanical Engineering from the California Institute of Technology. In recognition of her outstanding research contributions, she has received many honors including election as an AIMBE Fellow, the NSF Transitions Award, ACS Synthetic Biology Young Investigator Award, DOE Early Career Award, and NSF CAREER Award. She is also the recipient of several mentoring and teaching awards, including Boston University’s Award for Excellence in Mentoring Postdocs and the College of Engineering Teaching Excellence Award.

Optogenetic control of gene expression dynamics in single cells

Emerging approaches that integrate optogenetics with feedback control are transforming our ability to precisely manipulate microbial gene expression dynamics. In this talk, I will present how we harnessed deep neural networks and model predictive control to impose real-time, cell-specific gene expression patterns in bacteria, revealing crucial links between dynamic regulation and functional outcomes such as antibiotic resistance. I will also highlight our use of optogenetic tools and information theory to understand how variable expression of a key transcription factor influences downstream stress response genes and impacts bacterial survival under antimicrobial stress. These approaches provide new insights into the significant roles of cellular heterogeneity and dynamic regulation, advancing our understanding of gene expression and microbial behavior at the single-cell level.

Host: Daniel Jones daniel.jones@icm.uu.se, UU

[Spotlight Seminar Series] The innate power of natural killer cells in cancer therapy
2025-12-16 15:15 - 16:15 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Professor Karl-Johan Malmberg (M.D. Ph.D) , Oslo University

Biography

Professor Karl-Johan Malmbergis a Specialist in Hematology with over 25 years of experience in NK cell research and cancer immunotherapy. He is the Director of a Norwegian Research Council Center of Excellence, The Precision Immunotherapy Alliance (PRIMA) and leads an international team of 20 scientists based in laboratories both at the University of Oslo, Norway and the Karolinska Institutet, Sweden. He is also the Scientific Director of the Center for Advanced Cell and Gene Therapy (ACT) at Oslo University Hospital. The group focus on deciphering basic cellular and molecular mechanisms regulating NK cell function and seek to translate insights from these efforts in the design of novel approaches for NK-cell based cancer immunotherapy against cancer.

Relevant Publications

The innate power of natural killer cells in cancer therapy.

Sohlberg E, Malmberg KJ.Nat Med. 2025 Jun;31(6):1755-1756. doi: 10.1038/s41591-025-03712-9.PMID: 40355615

Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping.

Netskar H, Pfefferle A, Goodridge JP, Sohlberg E, Dufva O, Teichmann SA, Brownlie D, Michaëlsson J, Marquardt N, Clancy T, Horowitz A, Malmberg KJ.Nat Immunol. 2024 Aug;25(8):1445-1459. doi: 10.1038/s41590-024-01884-z. Epub 2024 Jul 2.PMID: 38956379

Host: Adnane Achour adnane.achour@ki.se

SciLifeLab PULSE - information webinar for applicants
2025-12-18 00:00 - 23:59 | Online event via Zoom
This webinar (two time options available) gives PULSE applicants an opportunity to receive information on e.g. the matchmaking and application process, as well as eligibility rules. There will also be time for Q&A:s. Find out more about the SciLifeLab PULSE postdoc program here The 2nd SciLifeLab PULSE Call opened on December 15!

Webinar registration

Webinar on December 18, 2025, at 09:00 am, UTC+1

Register here

Webinar on December 18, 2025, at 16:00 pm, UTC+1

Register here

Mapping cells at scale: from tissue volumes to community challenges in vEM
2026-01-20 15:15 - 16:15 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Speaker: Aubrey WeigelProject Scientist, CellMap Project TeamHoward Hughes Medical Institute, Janelia Research Campus

Abstract

Large-scale, high-resolution imaging of subcellular architecture using volume electron microscopy (vEM) unlocks new opportunities for biological discovery – but realizing this potential requires more than just data acquisition. Scalable infrastructure, robust protocols, and trained personnel are critical to extract consistent insight from these complex datasets and make them useful to the broader community. The CellMap Project Team represents a coordinated effort to scale vEM-based segmentation across six dimensions: dataset scale, biological diversity, organelle classification complexity, team training, analytical depth, and open access.

Through modular training programs, systematic quality control, and block-wise processing tools, the project has grown from individual cell volumes to tissue-scale annotation across dozens of organisms and sample types. Annotated datasets are openly shared through OpenOrganelle, providing the community with immediate access to high-resolution volumes and voxel-level segmentations. To further catalyze progress in automated segmentation, we launched the CellMap Segmentation Challenge – a large-scale, open competition featuring expertly annotated training data from over 20 eFIB-SEM datasets and more than 40 unique organelle classes.

We describe how workflows and infrastructure evolved to support this scaling effort, with a focus on designing datasets that are tailored for specific biological insight yet structured for broad reuse. By scaling people, protocols, and pipelines in parallel – and committing to open data practices – the CellMap Project Team provides a model for reproducible, high-resolution cellular mapping at scale.

registration

Biography

Aubrey Weigel is currently a Project Scientist of the CellMap Project Team at HHMI – Janelia Research Campus. The team uses advanced imaging technologies to study the ultrastructure of subcellular organelles under both healthy and pathological conditions. Aubrey’s previous research background is in biophysics, with an emphasis in microscopy. Her formal training is in physics and engineering.

During her graduate work Aubrey was the co-discoverer of ergodicity breaking in cells along with Diego Krapf, driving a pivotal shift in the field of diffusion analysis in living systems. Throughout her postdoctoral career under the guidance of Jennifer Lippincott-Schwartz, she applied her training in physics and microscopy directly to answer biological questions. Here, Aubrey unraveled the underlying structure of the endoplasmic reticulum and revealed its complex dynamics. She also uncovered the nano-anatomy of early secretory compartments and discovered a new, dynamic organelle, responsible for delivering newly synthesized cargo from the endoplasmic reticulum to the Golgi.

Aubrey’s recent work as the leader of the Cell Organelle Segmentation in Electron Microscopy (COSEM) project includes developing an invaluable tool for cell biology – an analysis pipeline based on deep learning architectures for segmentation – allowing comprehensive reconstruction and analysis of organelles within entire cells imaged by volumetric electron microscopy. CellMap is now building upon this pipeline to generate, characterize, and discover how cells look in their native tissue environments – acting as a hub of collaborations that brings together scientists of different disciplines. Aubrey is committed to integrating her multi-disciplinary training into facilitating large-effort, collaborative, team projects to take on challenging scientific problems and sharing these resources with the broader scientific community.

Unlocking Precision Health: From Molecular Insights to Clinical Impact in Complex Diseases
2026-01-23 09:00 - 17:00 | Operaterassen, Karl XII:s Torg, Stockholm, Sweden
The 3rd Symposium on Complex Diseases

Join us for an exciting day dedicated to advancing precision health and tackling the challenges of complex diseases. This symposium brings together leading researchers, clinicians, and industry to explore how molecular insights can transform clinical practice and improve patient outcomes.

For information about the symposium in Swedish: Unlocking Precision Health: From Molecular Insights to Clinical Impact in Complex Diseases (Swe).

Confirmed Speakers:

Oskar Frisell, Karolinska Institutet

Andrea Ganna, University of Helsinki, Finland

Lina Jonsson, University of Gothenburg

Richard Landberg, Chalmers University of Technology

Tuuli Lapalainen, KTH Royal Institute of Technology

Ruth Loos, University of Copenhagen, Denmark

Olle Melander, Lund University

Richard Rosenquist Brandell, Karolinska Institutet

Peter Würtz, Nightingale Health, Finland

Registration

Register via this form: https://forms.gle/6C7QzrzxwJ9NBPjd8. Registration deadline: 15 January 2026

Abstract Submission deadline: 5 January 2026

Program

Program symposium complex diseases Jan 23 2026_FINALDownload

Why attend?

Expand your expertise in genomics, multi-omics, and precision medicine.

Network with experts and peers across academia, healthcare, and industry.

Participate in rapid talks, poster sessions, and lively discussions.

Genetic code reprogramming for the discovery of macrocycles for therapeutic innovation
2026-01-23 10:00 - 11:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Hiroaki Suga, Ph.D.Professor, Department of Chemistry, School of Science, The University of Tokyo

Hiroaki Suga is best known for his work on artificial ribozymes (Flexizyme) and their application in mRNA display (RaPID, random nonstandard peptide integrated discovery). He is also the founder of the very successful drug discovery company PeptiDream, Inc. He was awarded the Wolf Prize in Chemistry in 2023.

Host: David Drew, SciLifeLab

[The Svedberg seminar] - How to Terminate Transcription at the Right Place
2026-01-26 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Gene‑Wei Li

Associate Professor Massachusetts Institute of Technology (MIT), USA

Bio

Gene‑Wei Li is an Associate Professor of Biology at Massachusetts Institute of Technology (MIT) and an Investigator at Howard Hughes Medical Institute (HHMI). He earned a B.S. in Physics from National Tsinghua University (2004) and a Ph.D. in Physics from Harvard University (2010), followed by a postdoctoral fellowship at University of California, San Francisco (UCSF). His research focuses on how bacterial genomes encode quantitative control over protein production — exploring how cells optimize proteome composition through precise regulation of transcription, translation, and RNA processing.

How to Terminate Transcription at the Right Place

Precise transcription termination is essential for defining gene boundaries and achieving proper RNA output. I will discuss two recent advances regarding transcription termination in bacteria. First, we re-defined the features required for intrinsic terminators: in addition to the canonical hairpin and U-tract, two conserved sequence motifs are also necessary. This new definition quantitatively explains variations in termination efficiency and accurately pinpoints functional terminators genome-wide. Second, we showed that many bacteria have evolved purine-rich genes to avoid premature transcription termination, especially in species with “runaway transcription,” i.e., those uncoupled transcription-translation. This bias imposes strong evolutionary constraints on codon usage and the assimilation of foreign genes. Together, these principles illuminate the design principles of bacterial gene sequences and how genomes encode the correct endpoints of transcription

Host: Johan Elf johan.elf@icm.uu.se UU

Metabolomics in Life Science
2026-01-27 08:00 - 2026-01-28 15:00 | Väven, Storgatan 46A, Umeå, 90326, Sweden
After the great success of the 2024 Metabolomics in Life Science conference, the Organizing Committee is thrilled to announce the second edition in 2026!Date: 27-28 January, 2026Venue: Vävenscenen, Umeå

Umeå University warmly invites you to Metabolomics in Life Science 2026, showcasing the latest NMR- and MS-based metabolomics research from Sweden, the Nordics, and beyond. The conference brings together researchers from around the world to share knowledge and discuss advances in areas like clinical and precision medicine, plant metabolomics, spatial and single-cell metabolomics, multi-omics, and computational/AI applications.

The event is organized by SciLifeLab platforms in Umeå: Swedish NMR Centre (SNC), Swedish Metabolomics Centre (SMC), and Computational Analytics Support Platform (CASP).

The program includes six keynote speakers from leading institutions, plus an industry exhibition showcasing the latest technologies and services in metabolomics research.

Registration is now open – Register here

Questions? Contact:

Ilona Dudka – ilona.dudka@umu.se

Kate Bennett – katie.bennett@umu.se

Looking forward to welcoming everyone in Umeå in January 2026!

Read more

OrganizersSwedish Metabolomics Centre (SMC)

NMR Core facility

Computational Analytics Support Platform (CASP)

How to Terminate Transcription at the Right Place
2026-01-27 14:00 - 15:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Gene‑Wei Li, Associate Professor Massachusetts Institute of Technology (MIT), USA

Abstract

Precise transcription termination is essential for defining gene boundaries and achieving proper RNA output. I will discuss two recent advances regarding transcription termination in bacteria. First, we re-defined the features required for intrinsic terminators: in addition to the canonical hairpin and U-tract, two conserved sequence motifs are also necessary. This new definition quantitatively explains variations in termination efficiency and accurately pinpoints functional terminators genome-wide. Second, we showed that many bacteria have evolved purine-rich genes to avoid premature transcription termination, especially in species with “runaway transcription,” i.e., those uncoupled transcription-translation. This bias imposes strong evolutionary constraints on codon usage and the assimilation of foreign genes. Together, these principles illuminate the design principles of bacterial gene sequences and how genomes encode the correct endpoints of transcription.

Biography

Gene‑Wei Li is an Associate Professor of Biology at Massachusetts Institute of Technology (MIT) and an Investigator at Howard Hughes Medical Institute (HHMI). He earned a B.S. in Physics from National Tsinghua University (2004) and a Ph.D. in Physics from Harvard University (2010), followed by a postdoctoral fellowship at University of California, San Francisco (UCSF). His research focuses on how bacterial genomes encode quantitative control over protein production — exploring how cells optimize proteome composition through precise regulation of transcription, translation, and RNA processing.

Host; Vicente Pelechano vicent.pelechano@scilifelab.se

High-Speed AFM and Cryo-EM: Dynamics and Structures of Membrane Proteins
2026-01-27 15:15 - 16:15 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Simon Scheuring

Weill Cornell Medicine, USA

Simon Scheuring is Distinguished Professor of Anesthesiology Research in the Department of Anesthesiology at Weill Cornell Medicine in New York, USA.

He is a trained biologist (Biozentrum, University of Basel, Switzerland). During his MSc and PhD, he learned electron microscopy (EM) and atomic force microscopy (AFM) for the structure determination of membrane proteins such as aquaporins and sugar transporters. During his postdoc and as research assistant (Institut Curie, Paris, France), he learned membrane physical chemistry and developed AFM for the study of native membranes and ventured into setting up his lab as a junior research director at the Institut Curie. Promoted to senior research director, he built a larger laboratory in Marseille (INSERM / Aix-Marseille Université, France). In 2017, he moved to Weill Cornell Medicine, where he got appointed as Professor in the Department of Anesthesiology (WCM, New York, USA). Simon Scheuring’s laboratory develops and applies AFM-technologies for the study of membrane phenomena, such as membrane protein structure, assembly, diffusion, and conformational dynamics of unlabeled single molecules, bridging structure and function. Over the past years, his laboratory has been instrumental in the development of High-Speed AFM (HS-AFM) methods, extracting quasi-atomic structural details from single molecule AFM data, and reaching millisecond temporal resolution for the analysis of conformational dynamics. In recent works, his laboratory combines HS-AFM with cryo-EM to acquire an integrated understanding of the dynamics and structures of membrane proteins.

Abstract

High-speed atomic force microscopy (HS-AFM) is a powerful technique that provides dynamic movies of biomolecules at work. First, I will briefly review our recent developments to break temporal limitations to characterize molecular dynamics by developing HS-AFM line scanning (HS-AFM-LS) and HS-AFM height spectroscopy (HS-AFM-HS) [1], and resolution limitations by developing Localization AFM (LAFM) [2]. Then, I will detail how we used HS-AFM to analyze membrane-embedded TRPV3 at the single-molecule level, and discovered a previously unobserved, transient, and reversible pentameric state of TRPV3, while cryo-EM analysis allowed to resolve the first structure of a pentameric TRP channel [3,4]. Finally, I will report about our most recent efforts to develop and apply 3D-AFM for the characterization of the water structure on protein surfaces [5].

References:

[1] Heath et al., Nature Communications, 2018, 9(1):4983, High-Speed AFM Height Spectroscopy (HS-AFM-HS): Microsecond dynamics of unlabeled biomolecules.

[2] Heath et al., Nature, 2021, 594(7863):385–390, doi:10.1038/s41586-021-03551-x, Localization Atomic Force Microscopy.

[3] Lansky et al., Nature, 2023, 621(7977), 206–214, doi:10.1038/s41586-023-06470-1, A pentameric TRPV3 channel with a dilated pore.

[4] Lansky et al. Nature Communications, 2025, 16(4520). https://doi.org/10.1038/s41467-025-59798-9, Structural dynamics and permeability of the TRPV3 pentamer. [5] Ma et al., submitted, 2025, Aquaporins destructure water above the pore.

Host: Stavros Azinas stavros.azinas@scilifelab.se

Calls for new project support in Chemical Biology and Drug Discovery
2026-01-30 12:00 - 13:00 | Online event via Zoom
The Chemical Biology Unit (CBCS) and the Drug Discovery and Development (DDD) platform at SciLifeLab have calls out for projects.

CBCS is seeking projects in Chemical Biology that include assay development for small-molecule screening and profiling, as well as enabling chemistry.

For more information, please visit www.cbcs.se.

The DDD platform is looking for new project proposals for drug discovery. All therapeutic modalities that can be developed in collaboration with the DDD platform at SciLifeLab are of interest, including small molecules, antibodies, oligonucleotides and new modalities.

Some users and projects are at the intersection between chemical biology and drug discovery. This webinar aims to guide users to the call that best suits the needs of their project

Register here!

Organizer: the Chemical Biology Consortium Sweden and the Drug Discovery & Development platform

Information seminar on KAW/SciLifeLab Proof of Concept call for grants 2026
2026-01-30 13:00 - 14:30 | Online event via Zoom
The 4th call for KAW/SciLifeLab Proof of Concept grants in Life Science is open for applications!

The purpose of the Proof of Concept grant is to bridge the gap from academic research to innovations in life science. The grant gives researchers the opportunity to develop their early-stage discoveries towards validated methods, products or processes and provides the opportunity to carry out activities that validate and accelerate the development of the project and prepare for innovation and commercialization.

Watch the seminar below to learn more about the call. ↓

Register to the Seminar

Program

13.00The KAW/SciLifeLab Proof of Concept grants in Life Science, Olli Kallioniemi, Professor of Molecular Precision Medicine, KI, Lilian Wikström, KAW13.20Project presentation – Marie Jeansson, KITherapeutic intervention to slow progression of chronic kidney disease13.40Project presentation – Pål Stenmark, Stockholm UniversityInnovative therapeutic toxins for the treatment of neuromuscular disorders14.00Open discussionModerator – Isolde Palombo, KTH

Application period

Call opens: January 13, 2026Call closes: February 20, 2026 at 13:00

Read more about the Call

Research seminar for Associate Senior Lecturer, SciLifeLab Fellow position in inflammation research
2026-02-02 13:00 - 15:45 | Navet, SciLifeLab Uppsala, SciLifeLab Uppsala, BMC C11, Husargatan 3, Uppsala, 75237, Sweden
Welcome to the seminars and discussions with candidates for the SciLifeLab Fellow position in inflammation research at Uppsala University.

Date: February 2, 2026

Time: 13:00 – 15:30

Location: The Triple room in SciLifeLab Navet, Entrance C11 at BMC, Husargatan 3, Uppsala. Or Zoom.

Organized by the SciLifeLab Uppsala University Committee

Registration

Please register to reserve a seat onsite or get the Zoom link to attend online.

Join the Zoom meeting by following the “Link to online event” in the Confirmation email. We will also send an e-mail reminder the day before the event with a button to “Join the Zoom meeting”.

Zoom attendees: You will be placed in a waiting room until the host opens the meeting. You will be muted and off camera upon entry. We kindly ask participants to remain muted during the presentations and to submit questions in the Q&A field. The Host will address questions after each presentation.

Registration

Program

13:00 Welcome, Hosts Prof. Anna Dimberg and Prof. Aristidis Moustakas

13:05 Expanding Kidney-Resident Bregs In Vivo: A New Level on Kidney Inflammation, Kailash Singh

13:40 Precision Targeting of Inflammation Beyond Corticosteroids, Aida Paivandy

14:15 Short break

14:25 Restoring immune tolerance in autoimmunity: autoreactive B cells and redox-controlled cellular strategies, Mike Aoun

15:00 Differential immune responses in Necrotizing Soft Tissue infections, Laura Palma Medina

15:30 Summary of the research seminars, Prof. Aristidis Moustakas

Program2.0_260202_Fellow position seminarDownload
