BEGIN:VCALENDAR VERSION:2.0 PRODID:-//SciLifeLab - ECPv6.15.18//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:SciLifeLab X-ORIGINAL-URL:https://www.scilifelab.se X-WR-CALDESC:Events for SciLifeLab REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20220327T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20221030T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20230326T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20231029T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230601T120000 DTEND;TZID=Europe/Stockholm:20230601T130000 DTSTAMP:20260404T001422 CREATED:20230101T215650Z LAST-MODIFIED:20230529T143235Z UID:10000776-1685620800-1685624400@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Xuexin Li and Darko Mitrovic DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nXuexin Li\n\n\n\nOscar Fernandez-Capetillo – alpha 4 \n\n\n\nFacilitating In Silico Drug Discovery-The Drug Repurposing Encylopedia \n\n\n\n\n\nDarko Mitrovic\n\n\n\nLucie Delemotte – gamma 3 \n\n\n\nExploring the Conformational Landscape of Membrane Proteins Using Molecular Simulations \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-jun-1/ LOCATION:Milkyway SciLifeLab Solna\, Tomtebodavägen 23\, Solna CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_120135408_HDR-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230605T080000 DTEND;TZID=Europe/Stockholm:20230609T170000 DTSTAMP:20260404T001422 CREATED:20230317T095301Z LAST-MODIFIED:20230317T150114Z UID:10000839-1685952000-1686330000@www.scilifelab.se SUMMARY:Hackathon on Web and Cloud Infrastructure for AI-Powered BioImage Analysis DESCRIPTION:We are proud to announce the upcoming hackathon (a.k.a. codefest) event\, “Web and Cloud Infrastructure for AI-Powered BioImage Analysis” on June 5th-9th\, 2023\, at SciLifeLab\, Solna. As leading partners in the AI4Life consortium\, which is funded through the Horizon Europe Research Infrastructure Grant\, SciLifeLab and KTH are organizing this event to bring together the computational and life science communities\, shaping the future of Data-Driven Life Sciences! \n\n\n\nIn the AI4Life consortium\, we focus on building web and cloud infrastructure aimed at addressing the challenges of building and deploying AI tools for bioimage analysis and making them more scalable and easily accessible from the BioImage Model Zoo.  \n\n\n\nFor the hackathon\, we are inviting international experts and hackers on AI-based image analysis and web & cloud infrastructure to lead discussions and form interest groups to hack on related topics. It will feature discussions on our current status and plans in building web and cloud infrastructure for running models in the BioImage Model Zoo\, as well as the opportunity to form interest groups to hack on related topics in breakout sessions during the week. \n\n\n\nIf you are interested in participating\, please RSVP by April 15th\, 2023\, and let us know through this form: \n\n\n\nregistration\n\n\n\nPlease also note that the participants’ number of the event is limited to 15\, and in case of overbooking\, we will select based on the relevance of your current work and give priority to international participants outside Sweden. \n\n\n\nThe event is organized by Wei Ouyang\, a Data-Driven Life Science fellow who is leading the AICell Lab (https://aicell.io) and the development of the cloud-based AI infrastructure in the AI4Life consortium. \n\n\n\nWe are proud to have the support of Global BioImaging\, an international network of imaging infrastructures and communities. Together\, we are committed to generating new synergies in the community and to collecting feedback from users and experts in the field. \n\n\n\nContact at SciLifeLab: \n\n\n\nWei OuyangKTHDDLS FELLOWwei.ouyang@scilifelab.se +46762867366 URL:https://www.scilifelab.se/event/hackathon-on-cloud-based-and-ai-powered-bioimage-analysis/ CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/03/Ai-for-life.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230605T080000 DTEND;TZID=Europe/Stockholm:20230609T170000 DTSTAMP:20260404T001422 CREATED:20230317T162228Z LAST-MODIFIED:20230531T095005Z UID:10000841-1685952000-1686330000@www.scilifelab.se SUMMARY:1st cryoNET course on advanced single particle cryo-EM analysis DESCRIPTION:CryoNet is a Nordic network in cryogenic electron microscopy that aims to promote collaboration and knowledge sharing across national borders. A main goal is to help establish state-of-the-art cryogenic electron microscopy as a strong pillar of Nordic life science research. \n\n\n\nThe core of the network is constituted by the cryo-EM facilities at University of Copenhagen\, Aarhus University\, Stockholm University and Umeå University. \n\n\n\nWe are happy to announce the 1st cryoNET course on advanced single particle cryo-EM analysis that will take place at Aarhus University on 5-9 June 2023. Aim of the course is to provide training in cryo-EM image processing including the latest developments of the field. \n\n\n\nParticipants will receive hands-on training in state-of-the-art techniques for single particle cryo-EM image processing\, model building and validation from a range of international specialist guest lecturers. The course also includes theoretical talks and discussions on the use of cryo-EM to address difficult biological questions\, which can help the participants address their own research problems. \n\n\n\nParticipation in the entire course is mandatory and an attendance certificate will be given at the end of the course. \n\n\n\n \n\n\n\nCourse Objectives\n\n\n\n\nTo provide training in state-of-the-art techniques for structure determination using cryo-EM\n\n\n\nDiscuss data collection strategies\n\n\n\nTraining in basic principles of structure determination using cryo-EM\n\n\n\nHands-on practical training in the latest software suites for image processing of electron micrographs for high resolution structure determination\n\n\n\nDevelop problem solving skills through discussions and practical sessions in the presence of international experts in the field\n\n\n\nNetworking with experts\, software developers\, and researchers in cryo-EM and learn of not only the latest but also upcoming developments\n\n\n\nApplication and selection\n\n\n\n\nCourse fee payment deadline: 2 May 2023 \n\n\n\nThe registration fee: 1000 DKK and includes \n\n\n\n\nAttendance in the course 5-9 June 2023\n\n\n\nLunches\, coffee and refreshments on the course dates\n\n\n\nCourse materials\n\n\n\nCertificate of attendance\n\n\n\nCourse dinner on second night of the course (arranged by the course hosts in Aarhus city)\n\n\n\n\nPlease note\, the registration fee does not cover hotel\, travel expenses\, breakfasts\, and dinners (expect the course dinner second night) \n\n\n\nProgram\n\n\n\nProgram_1st-CryoNET-course-5-9-June-2023Download\n\n\n\nSupported by\n\n\n\n\nKnut & Alice Wallenberg Foundation\n\n\n\nNovo Nordisk Foundation\n\n\n\nNordforsk\n\n\n\nThermo Fisher Scientific\n\n\n\n\nOrganising committee\n\n\n\nThomas Boesen\, Aarhus University \n\n\n\nKarin Walldén\, Stockholm University \n\n\n\nMarta Carroni\, Stockholm University \n\n\n\nKaren Bech-Pedersen\, Aarhus University \n\n\n\nJesper Lykkegaard Karlsen\, Aarhus University \n\n\n\nAndreas Bøggild\, Aarhus University URL:https://www.scilifelab.se/event/1stfirst-cryonet-course-on-advanced-single-particle-cryo-em-analysis/ LOCATION:Aarhus University\, Department of Molecular Biology and Genetics\, Universitetsbyen 81\, Århus\, Denmark CATEGORIES:Course ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/03/cover3.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230607T120000 DTEND;TZID=Europe/Stockholm:20230607T124500 DTSTAMP:20260404T001422 CREATED:20230511T125240Z LAST-MODIFIED:20230529T151705Z UID:10000890-1686139200-1686141900@www.scilifelab.se SUMMARY:Knut and Alice Wallenberg Foundation and SciLifeLab Proof of Concept Grant in Life Science (lunch seminar) DESCRIPTION:Lunch seminar (also available through Streamo) where a new call for proof-of-concept funding aiming to ignite life science innovation will be presented. \n\n\n\nRegister\n\n\n\nAre you financed through Knut and Alice Wallenberg Foundation\, a SciLifeLab researcher or infrastructure staff with ideas for commercialization\, this seminar is for you. \n\n\n\nLunch sandwiches will be served for participants attending in person. Register now on the link below. \n\n\n\nThe purpose of the Proof of Concept grant is to bridge the gap from academic research to innovations in life science. The grant gives researchers the opportunity to develop their early-stage discoveries towards validated methods\, products or processes and  provides the opportunity to carry out activities that validate and accelerate the development of the project and prepare for innovation and commercialization. \n\n\n\nThe Proof of Concept grant is not meant as a translational academic research grant\, but as a specific goal-oriented project to develop an academic discovery towards an innovation and a product. Hence\, translational research without a clear product-oriented thinking or a defined goal at the end of the two year period is not something that can be supported. The Proof of Concept grant is tied to the Wallenberg Launch Pad (WALP) mechanism (see below) that provides support for academic scientists to develop innovations that make an impact in society. \n\n\n\nThe approved funding for each project is suggested to be between 1 and 4 million SEK\, over a project period of a maximum of two years. The grant will be paid directly to the researcher’s university and the use of the grant must comply with the university’s regulations and the specific terms and conditions of the grant as stated by Knut and Alice Wallenberg Foundation (KAW). This is a yearly call.  \n\n\n\nApplication period \n\n\n\nThe application period for 2023 begins June 7. Last day of application August 17 at 13.00. \n\n\n\nRead more URL:https://www.scilifelab.se/event/save-the-date-for-lunch-seminar-on-upcoming-call-proof-of-concept-funding/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/05/Proof-of-Concept-scaled.jpeg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230607T140000 DTEND;TZID=Europe/Stockholm:20230607T153000 DTSTAMP:20260404T001422 CREATED:20230525T130718Z LAST-MODIFIED:20230602T083032Z UID:10000891-1686146400-1686151800@www.scilifelab.se SUMMARY:FAIRPoints Ask Me Anything on Machine actionability - Online DESCRIPTION:Please join SciLifeLab Data Centre in collaboration with FAIRPoints\, RDA\, EOSC\, and FDO for the upcoming events FAIRPoints Ask Me Anything on Machine actionability. \n\n\n\nWe warmly invite you to join us for this beginner friendly session of FAIRPoints Ask Me Anything\, diving deep into the world of machine actionability.This thought-provoking discussion will explore the essentials for achieving machine actionability such as semantics\, metadata\, operations\, and types. We’ll also delve into why automation is an integral part of research\, how researchers are creating machine actionable research outputs\, and the tools available to facilitate these applications.Our distinguished speakers include Claus Weiland and Ivonne Anders. Dr. Claus Weiland\, researcher at Senckenberg Biodiversity and Climate Research Centre (SBIK-F) (https://www.rd-alliance.org/users/claus-weiland) and Dr. Ivonne Anders\, researcher at DKRZ (https://www.rd-alliance.org/users/ianders). Lead by our moderators Juliane Schneider\, Emma Wilson and Andrea Medina Smith. \n\n\n\nDate & Time: NEW DATE: June 7th 14:00 – 15:30 Swedish time (12:00 – 13:30 UTC) \n\n\n\nRegister:  https://shrtco.de/uxXY2WTarget group: researchers\, infrastructure\, technical staff\, interested \n\n\n\n \n\n\n\nWelcome! You are invited to join a meeting: FAIRPoints ‘Ask Me Anything’ webinar on Machine actionability. After registering\, you will receive a confirmation email about joining the meeting.This event is hosted by FAIRPoints (https://fairpoints.org/) and supported by RDA (https://www.rd-alliance.org/)\, EOSC (https://eoscfuture-grants.eu/) & SciLifeLab-DataCentre (https://www.scilifelab.se/data) in collaboration with FDO (https://fairdo.org/). \n\n\n\nMore information or inquiries please contact Dr Sara El-Gebali\, Project lead for metadata and curation\, SciLifeLab Data Centre at datacentre@scilifelab.se or fairpoints@protonmail.com URL:https://www.scilifelab.se/event/fairpoints-ask-me-anything-on-machine-actionability/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="SciLifeLab Data Centre":MAILTO:datacentre@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230608T120000 DTEND;TZID=Europe/Stockholm:20230608T130000 DTSTAMP:20260404T001422 CREATED:20230101T220003Z LAST-MODIFIED:20230608T080330Z UID:10000777-1686225600-1686229200@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Artemy Zhigulev and Ricky Molen DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nArtemy Zhigulev\n\n\n\nPelin Sahlen – alpha 3 \n\n\n\nEnhancer mutations modulate the severity of chemotherapy-induced myelosuppression \n\n\n\n\n\nRicky Molen\n\n\n\nJens Lagergren – gamma 6 \n\n\n\nVariation Inference with Mixtures: The Tool for Phylogenetic Inference? \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-jun-8/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_124630107_HDR-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230611T090000 DTEND;TZID=Europe/Stockholm:20230622T170000 DTSTAMP:20260404T001422 CREATED:20230216T102719Z LAST-MODIFIED:20230216T130225Z UID:10000812-1686474000-1687453200@www.scilifelab.se SUMMARY:RaukR\, Advanced R for Bioinformatics workshop DESCRIPTION:International course. The course is open for researchers at university or in industry such as PhD students\, postdocs\, group leaders\, core facility staff and analysts. \n\n\n\n\n\n\n\nCourse description\n\n\n\nJoin us this June in beautiful and historic Visby to improve your R skills and have a nice time!In Life Science and Bioinformatics\, R is increasingly being used to transform and analyse data\, perform statistical analysis and produce publication-ready visualisations. This workshop will focus on advanced R functionality\, to increase the participants skillset and understanding of what is possible to do today. \n\n\n\nYou are very welcome to apply or see the website for more information. Please\, help us spread the word to interested participants! \n\n\n\n\n\n\n\nImportant dates\n\n\n\nApplication deadline: Fri\, 14.04.2023\, 24:00GMT \n\n\n\nNotification of acceptance/decline: Fri\, 21.04.2023 \n\n\n\nResponsible teachers: Marcin Kierczak\, Sebastian DiLorenzo\, Roy FrancisContact: RaukR@NBIS.se \n\n\n\n\n\n\n\n\n\nCourse website\n\n\n\n\n\nApplication\n\n\n\n\n\n\n\n\n\n\n\n\n\nCourse fee\n\n\n\nAcademic: 10 000 SEK (Includes participation in all official activities and events\, course materials\, breakfast\, lunch and accommodations). \n\n\n\nParticipants from outside of academia should contact us for a fee quote. \n\n\n\nThe fee does not include travel costs. \n\n\n\n\n\n\n\nGuest speakers\n\n\n\nJenny Bryan (software engineer at RStudio\, Data science professor at UBC) (link to https://jennybryan.org/about/)Yihui Xie (software engineer at RStudio) (link to https://yihui.org/en/)Max Kuhn (software engineer at RStudio) (link to https://www.rstudio.com/authors/max-kuhn/)Christophe Dervieux (software engineer at RStudio) (link to https://cderv.rbind.io/about/) \n\n\n\n\n\n\n\nCourse content\n\n\n\n\nReproducible research in R (Quarto\, Rmarkdown\, Knitr)\n\n\n\nCollaborative work using Git and GitHub\, CD/CI\n\n\n\nR code style guide & best practices\n\n\n\nCode debugging\, optimization and profiling\n\n\n\nParallelisation and vectorization in R\n\n\n\nWriting own functions\n\n\n\nUnderstanding and using the system of R classes: S3\, S4\, R6 and RC\n\n\n\nAnatomy of an R package: writing your own package from scratch\n\n\n\nTidy data flow with tidyverse\n\n\n\nUsing the language of graphics\, ggplot2\n\n\n\nDeveloping simple web applications using shiny\n\n\n\nR and Python integration using reticulate\n\n\n\nStreamlined modelling using tidymodels\n\n\n\nTeam project work – developing data analyses workflow in R using acquired skills\n\n\n\n\n\n\n\n\nEntry requirements\n\n\n\nThe course is aimed at both Ph.D. students and researchers within Life Sciences who are already using R for basic bioinformatics analyses and who would like to start using R at a more advanced level. In order for you and other participants to benefit the most\, you should consider yourself eligible if you are comfortable with reading and transforming data\, installing and using third-party packages and plotting using standard R graphics. \n\n\n\nWe offer places for participants from all over the world\, but there is a number of places reserved for participants from Sweden. \n\n\n\n\n\n\n\nSelection criteria\n\n\n\nThis year\, the school can accommodate ~42 participants. Selection criteria include correct entry requirements\, motivation to attend the course as well as gender and geographical balance. URL:https://www.scilifelab.se/event/raukr-advanced-r-for-bioinformatics-workshop-2/ CATEGORIES:Course ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/02/Visby-1.jpg ORGANIZER;CN="NBIS - National Bioinformatics Infrastructure Sweden":MAILTO:education@nbis.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230612T140000 DTEND;TZID=Europe/Stockholm:20230612T150000 DTSTAMP:20260404T001422 CREATED:20230609T113238Z LAST-MODIFIED:20230609T113300Z UID:10000911-1686578400-1686582000@www.scilifelab.se SUMMARY:The first protein sweetener fit for the mass food market DESCRIPTION:Speaker\n\n\n\nIlan Samish\, Amai Proteins \n\n\n\nHost\n\n\n\nArne Elofsson\, SciLifeLab \n\n\n\nAbstract\n\n\n\nSugar underlies the metabolic syndrome\, the topmost health problem of the world. Unfortunately\, the eight different categories of sugar reduction cannot reduce >30% of sugar without compromising the need for a tasty\, cost-efficient solution\, not to mention one which is healthy and sustainable. Hyper-sweet proteins\, found along the equatorial belt\, enable significant sugar reduction. Unlike small-molecule sweeteners\, they are digestible and consequently are not anticipated to ignite adverse effects inside our body. Yet\, they are costly\, unstable and have a compromised sensory profile. Here we present sweelin™\, a stable protein which enables up to 80% sugar reduction without compromising cost or taste as assessed by Amai’s supertaster panel. The novel protein was developed by optimizing the core\, loops\, and electrostatics of monellin\, a hyper-sweet and unstable protein. Following the AI-CPD (Computational Protein Design)\, the protein is manufactured via microbial precision fermentation. With numerous fee-bearing agreements with large food and beverage multinationals\, sweelin™ will be regulatory approved this year. The synergistic combination of AI-CPD\, microbial precision fermentation and food technology\, enables the development of numerous ‘super-proteins’ fit for the mass food market. URL:https://www.scilifelab.se/event/the-first-protein-sweetener-fit-for-the-mass-food-market/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230613T151500 DTEND;TZID=Europe/Stockholm:20230613T161500 DTSTAMP:20260404T001422 CREATED:20230524T093330Z LAST-MODIFIED:20230524T130749Z UID:10000897-1686669300-1686672900@www.scilifelab.se SUMMARY:[The Svedberg seminar] -Physical activity and cancer: Improving causal inference DESCRIPTION:NOTE THAT THIS SEMINAR IS ON A TUESDAY \n\n\n\nBrigid M. Lynch\, Associate Professor \n\n\n\nDeputy Head\, Cancer Epidemiology Division\, Cancer Council Victoria \n\n\n\nHonorary Principal Fellow\, Centre for Epidemiology and Biostatistics\, Melbourne School of Population and Global Health\, University of Melbourne\, Australia \n\n\n\nBio\n\n\n\n \n\n\n\n\n\n\n\nBrigid Lynch is a cancer epidemiologist whose research focuses on how physical activity is associated with cancer risk\, biological mechanisms underlying risk\, and health outcomes for cancer survivors. Her research interests include applying causal inference methods to help advance the field of physical activity epidemiology. Brigid is a Principal Investigator of the Australian Breakthrough Cancer Study\, an ongoing cohort study of over 50\,000 Australians investigating the role that genes\, lifestyle and environment play in the development of cancer and other diseases. \n\n\n\n \n\n\n\nPhysical activity and cancer: Improving causal inference\n\n\n\nCancer is a leading cause of ill health and mortality; a clear understanding of cancer risk factors is critical to developing effective cancer control strategies. Physical activity has a protective effect for a number of cancers\, however it is – at best – a tangential focus of cancer control agencies around the world. The epidemiological evidence for physical activity and cancer (both in terms of risk and survivorship after diagnosis) is subject to numerous biases\, creating a lack of certainty about causal effects. This presentation will present example studies focused on breast cancer to describe how we can triangulate evidence from different methods to improve causal inference in this field of enquiry. \n\n\n\n\n\n\n\n\n\n\n\nHost: Emerald Heiland\, UU emerald.heiland@surgsci.uu.se and Hannah Brooke\, UU hannah.brooke@surgsci.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-physical-activity-and-cancer-improving-causal-inference/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230614T153000 DTEND;TZID=Europe/Stockholm:20230614T171500 DTSTAMP:20260404T001422 CREATED:20230529T204841Z LAST-MODIFIED:20230602T141358Z UID:10000902-1686756600-1686762900@www.scilifelab.se SUMMARY:BAM seminar; How to design and present a scientific poster DESCRIPTION:We are delighted to host Dr. Kess Marks\, who is an instructor at Visualize Your Science\, a company dedicated to improving how science is communicated by researchers. Kess will give a seminar on how to design eye-catching posters that will leave your audience in awe. Further\, she will teach us how to deliver a spot-on presentation that matches the great poster design.Don’t miss out on this chance to become a poster design and presentation star! We will have a short fika break in the middle of the seminar\, please register! \n\n\n\nWho the event is aimed at i.e.\, who will attend : This seminar is tailored for everyone who is interested to learn more about scientific poster design and presentation. Welcome! \n\n\n\nSpeakers: Dr. Kess Marks from Visualize your Science \n\n\n\nZoom link\n\n\n\nRegister URL:https://www.scilifelab.se/event/bam-seminar-how-to-design-and-present-a-scientific-poster/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/11/BAM.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230615T120000 DTEND;TZID=Europe/Stockholm:20230615T130000 DTSTAMP:20260404T001422 CREATED:20230101T220347Z LAST-MODIFIED:20230607T091102Z UID:10000778-1686830400-1686834000@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Nayanika Bhalla and Jakob Rosenbauer DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nNayanika Bhalla\n\n\n\nPatrik Ståhl – alpha 3 \n\n\n\nAdipose Unveiled: Mapping the Spatial Transcriptomics Tapestry and Unearthing Hidden Cell Types \n\n\n\n\n\nJakob Rosenbauer\n\n\n\nJean Hausser – alpha 5 \n\n\n\nSingle-cell deconvolution of spatial transcriptomics data \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-jun-15/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_123412496_HDR2-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230616T090000 DTEND;TZID=Europe/Stockholm:20230616T100000 DTSTAMP:20260404T001422 CREATED:20230607T155128Z LAST-MODIFIED:20230607T155437Z UID:10000905-1686906000-1686909600@www.scilifelab.se SUMMARY:steinbock: a toolkit for processing multiplexed tissue images DESCRIPTION:Multiplexed imaging enables the simultaneous spatial profiling of dozens of biological molecules in tissues at single-cell resolution. Extracting biologically relevant information from multi-channel images involves computational tasks such as image segmentation and feature extraction\, which can pose technology-specific challenges to experimental biologists lacking adequate bioinformatics training. \n\n\n\nIn this hands-on webinar\, we will showcase steinbock\, a computational toolkit for batch-processing multiplexed tissue images using established tools and approaches\, without the need for additional programming. The steinbock toolkit can be used to rapidly extract spatially resolved single-cell data for downstream statistical analysis\, interfacing with popular analysis environments such as Python or R/Bioconductor. It is an essential part of the Analysis workflow for IMC data (Bodenmiller Lab\, ETH Zurich/University of Zurich) and further information can be found in the steinbock online documentation. \n\n\n\nThe webinar will be given by Jonas Windhager\, the creator and former maintainer of steinbock\, who recently joined the SciLifeLab BioImage Informatics Facility. It is aimed at experimental biologists with an interest in image analysis and is scheduled to last one hour or longer\, depending on interest. \n\n\n\nregistration URL:https://www.scilifelab.se/event/steinbock-a-toolkit-for-processing-multiplexed-tissue-images/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/06/steinbock-logo.png ORGANIZER;CN="Bioimage Informatics Unit":MAILTO:biif@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230622T120000 DTEND;TZID=Europe/Stockholm:20230622T130000 DTSTAMP:20260404T001422 CREATED:20230101T220709Z LAST-MODIFIED:20230614T120309Z UID:10000779-1687435200-1687438800@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Marianna Tampere and Guillaume Minet DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nMarianna Tampere\n\n\n\nPäivi Östling – alpha 4 \n\n\n\nMulti-layered drug profiling for repurposing medicines in infectious diseases – how infrastructure supports research \n\n\n\n\n\nGuillaume Minet\n\n\n\nIlaria Testa – gamma 3 \n\n\n\nModular parallelized RESOLFT setup for live-cell imaging \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-jun-22/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_120135408_HDR-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230628T110000 DTEND;TZID=Europe/Stockholm:20230628T120000 DTSTAMP:20260404T001422 CREATED:20230616T074651Z LAST-MODIFIED:20230616T074652Z UID:10000917-1687950000-1687953600@www.scilifelab.se SUMMARY:Call for new drug discovery pilot projects at SciLifeLab DDD with special emphasis on biologics and antibiotics DESCRIPTION:The DDD platform at SciLifeLab supports academic drug discovery project with expertise and technical capabilities. We have\, for example\, platforms to develop small molecule drugs\, therapeutic antibodies\, oligonucleotide therapeutics\, proximity-inducing agents such as bispecific antibodies and PROTACs.  \n\n\n\nIn this call\, the Drug Discovery and Development Platform (DDD) at SciLifeLab is looking for new pilot project proposals for drug discovery. All therapeutic modalities outlined above are of interest. Of special interest are new project ideas for (multispecific) biologics\, and in collaboration with ENABLE2 https://www.ilk.uu.se/enable2/\, small molecule projects for discovery of new antibiotics. \n\n\n\nNote that small projects for selections in phage display libraries for antibodies\, selections in DNA encoded chemical libraries for small molecules or limited screening for antisense or siRNA molecules can be considered.  \n\n\n\nA description of new modalities in drug discovery research can be found here: https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00582 \n\n\n\nIf you have questions about the call please contact DDD by email (dddprojectproposal@scilifelab.se). This call is open for scientists with a doctoral degree at a Swedish university or higher institution. English should be used when filling out this application. You are responsible for ensuring that the application is complete. Incomplete applications will not be processed. \n\n\n\nProgram\n\n\n\n11.00 Introduction to Anubis call for DDD pilot-projects\, Per Arvidsson \n\n\n\n11.05 Oligonucleotide therapeutics through OligoNova HUB at DDD\, Pär Matsson \n\n\n\n11.30 Questions & Answers \n\n\n\n11.45 End with a video about collaboration with SciLifeLab DDD featuring Marika Nestor\, Uppsala University \n\n\n\n \n\n\n\nWelcome!\n\n\n\nRegistration\n\n\n\nMore About the call\n\n\n\nLink to Online Event URL:https://www.scilifelab.se/event/call-for-new-drug-discovery-pilot-projects-at-scilifelab-ddd-with-special-emphasis-on-biologics-and-antibiotics/ CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230628T130000 DTEND;TZID=Europe/Stockholm:20230628T140000 DTSTAMP:20260404T001422 CREATED:20230529T134540Z LAST-MODIFIED:20230622T091701Z UID:10000898-1687957200-1687960800@www.scilifelab.se SUMMARY:Nya verktyg för att säkra biologisk mångfald i en föränderlig värld – vilken väg ska Sverige välja? DESCRIPTION:SciLifeLab i Almedalen\n\n\n\nUnder Almedalsveckan 2023 arrangerar SciLifeLab ett antal seminarier för att visa hur och debattera kring hur forskning och forskningsinfrastruktur kan bidra till att möta samhälleliga utmaningar vara för att fortsatt vara en ledande life science nation.Varmt välkommen att delta! \n\n\n\nOm du vill ha kontakt med projektteamet för SciLifeLab Almedalsveckan – kontakta Per Lek \n\n\n\n \n\n\n\nBeskrivning av samhällsfrågan\n\n\n\nJorden genomgår en biodiversitetskris. För att sätta in verksamma motåtgärder behöver vi en effektivare övervakning av biologisk mångfald än observationsstudier. En lösning är att göra DNA-analyser av miljöprover för att få information om arters närvaro och variation. Kan det vara vägen framåt? \n\n\n\nläs mer\n\n\n\nUtökad information om evenemanget:\n\n\n\nVår jord genomgår en biodiversitetskris. Arter förloras i ett allt högre tempo som en direkt följd av mänsklighetens expansion och påverkan på våra ekosystem och klimatet. För att motverka denna alarmerande utveckling måste vi kartlägga olika arters utbredning\, status och prognos. Här finns en utmaning: detta är resurskrävande och därför övervakar vi bara ett mindre urval arter vilket är otillräckligt för att utforma effektiva förvaltningsåtgärder. En väg framåt är att dra nytta av de nya analysmetoder som skapat förutsättningar för human precisionsmedicin. Samma utveckling är möjlig för att diagnostisera tillståndet i vår natur! Teknikutvecklingen går snabbt. DNA från miljöprov kan ge oss information om vilka arter som finns i närområdet samt kartlägga förekomsten av smittämnen och invasiva arter. Fördelarna och möjligheterna är många\, men finns det också en baksida? Vi bjuder in till diskussion om förutsättningar och risker med denna nya molekylära precisionsövervakning av miljön. \n\n\n\nMedverkande:\n\n\n\nStefan Bertilsson\, Professor\, Sveriges LantbruksuniversitetOlga Vinnere Pettersson\, PhD\, Uppsala UniversitetMikael Dahl\, Göteborg Universitet / IVL Svenska miljöinstitutetMats Svensson\, Avdelningschef\, Havs och Vatten myndighetenMathilda Karlsson\, Expert\, WWF SwedenGunilla Rosenqvist\, Projektledare\, Naturresurser och Hållbar utveckling\, Uppsala Universitet URL:https://www.scilifelab.se/event/nya-verktyg-for-att-sakra-biologisk-mangfald-i-en-foranderlig-varld-vilken-vag-ska-sverige-valja/ LOCATION:B-huset\, Campus Gotland\, Cramérgatan 3\, Visby\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/05/Almedalen-2022-platsen_JLG-1-scaled.jpg ORGANIZER;CN="SciLifeLab i Almedalen":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230629T120000 DTEND;TZID=Europe/Stockholm:20230629T130000 DTSTAMP:20260404T001422 CREATED:20230101T221012Z LAST-MODIFIED:20230530T095916Z UID:10000780-1688040000-1688043600@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Maximilian Senftleben DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nTBC\n\n\n\nHåkan Jönsson – alpha 4 \n\n\n\n \n\n\n\n\n\nMaximilian Senftleben\n\n\n\nHjalmar Brismar – gamma 3 \n\n\n\n \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-jun-29/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_124630107_HDR-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230629T130000 DTEND;TZID=Europe/Stockholm:20230629T140000 DTSTAMP:20260404T001422 CREATED:20230529T142924Z LAST-MODIFIED:20230531T101906Z UID:10000899-1688043600-1688047200@www.scilifelab.se SUMMARY:Bättre sjukvård och forskning tack vare Europasatsning på säker storskalig lösning för genomikdata DESCRIPTION:SciLifeLab i Almedalen\n\n\n\nUnder Almedalsveckan 2023 arrangerar SciLifeLab ett antal seminarier för att visa hur och debattera kring hur forskning och forskningsinfrastruktur kan bidra till att möta samhälleliga utmaningar vara för att fortsatt vara en ledande life science nation.Varmt välkommen att delta! \n\n\n\nOm du vill ha kontakt med projektteamet för SciLifeLab Almedalsveckan – kontakta Per Lek \n\n\n\n \n\n\n\nBeskrivning av samhällsfrågan\n\n\n\nFör att förbättra sjukvården (precisionsmedicin) och öka kunskapen om genetisk variation samt i framtiden möjliggöra förebyggande behandlingar arbetar Europa tillsammans för att på ett säkert sätt skall ge forskare och läkare tillgång till viktiga genomikdata. \n\n\n\nläs mer\n\n\n\nUtökad information om evenemanget:\n\n\n\nSverige leder tillsammans med Finland utvecklingen av infrastrukturen inom EU-projektet GDI (Genomic Data Infrastructure). Målet är att GDI redan år 2026 skall vara i drift i 15 länder. För att projektet skall nå sina mål behövs en bakomliggande datahantering som uppfyller de stora säkerhetskrav som ställs på denna typ av data. Vid seminariet kommer vi att informera om det pågående arbetet samt diskutera de möjligheter projektet ger för framtidens sjukvård och forskning\, de legala och tekniska utmaningar som finns\, och hur vi på bästa sätt engagerar oss från svensk sida. Arbetet i GDI är en del av det stora arbetet med att tillgängliggöra hälsodata inom Europa (EHDS\, European Health Data Space). \n\n\n\nMedverkande:\n\n\n\nBengt Persson\, Prof.\, Uppsala Universitet\, SciLifeLab\, ELIXIRRichard Rosenqvist Brandell\, Prof.\, Genomic Medicine SwedenAnna Hagwall\, Projektledare\, Nationell BioinformatikInfrastruktur SverigeManólis Nymark\, Jurist\, European 1+ Million Genome project URL:https://www.scilifelab.se/event/battre-sjukvard-och-forskning-tack-vare-europasatsning-pa-saker-storskalig-losning-for-genomikdata/ LOCATION:B-huset\, Campus Gotland\, Cramérgatan 3\, Visby\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/05/Almedalen-2022-platsen_JLG-1-scaled.jpg ORGANIZER;CN="SciLifeLab i Almedalen":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230629T160000 DTEND;TZID=Europe/Stockholm:20230629T170000 DTSTAMP:20260404T001422 CREATED:20230529T143138Z LAST-MODIFIED:20230627T064700Z UID:10000900-1688054400-1688058000@www.scilifelab.se SUMMARY:Hur ska Sverige hänga med i den snabba globala utvecklingen inom precisionsmedicin? DESCRIPTION:SciLifeLab i Almedalen\n\n\n\nUnder Almedalsveckan 2023 arrangerar SciLifeLab ett antal seminarier för att visa hur och debattera kring hur forskning och forskningsinfrastruktur kan bidra till att möta samhälleliga utmaningar vara för att fortsatt vara en ledande life science nation.Varmt välkommen att delta! \n\n\n\nOm du vill ha kontakt med projektteamet för SciLifeLab Almedalsveckan – kontakta Per Lek \n\n\n\n \n\n\n\nSverige har en hög ambition att vara världsledande inom life science och precisionsmedicin/hälsa. Hur skapar vi ett globalt konkurrenskraftigt Sverige som säkerställer att nya teknologier\, datadriven diagnostik\, individanpassad behandling och prevention kommer patienter och samhället till nytta? \n\n\n\nläs mer\n\n\n\nUtökad information om evenemanget:\n\n\n\nNya teknologier och datadriven vård möjliggör vassare diagnostik\, individanpassad behandling och sjukdomsprevention. SciLifeLab är en nationell infrastruktur som erbjuder spjutspetsteknologier och avancerad dataanalys och fungerar som ett drivhus för utveckling av nya diagnostiska verktyg. Parallellt arbetar Genomic Medicine Sweden (GMS) med implementering av genomikbaserad precisionsmedicin och möjliggör datadelning nationellt. Hur ska Sverige fortsätta att effektivt utveckla och integrera nya metoder i vården\, bedriva klinisk forskning och säkerställa att precisionsmedicin kommer till nytta för patienter? En sammanhållen organisation för precisionsmedicin mellan akademi\, sjukvård och industri skulle göra Sverige mer attraktivt för kliniska studier och för rekrytering av viktig kompetens. Vad är statens och regionernas ansvar för att säkerställa långsiktig finansiering och likvärdig tillgång till precisionsmedicin i Sverige? Och hur står vi oss i den allt hårdare globala konkurrensen? \n\n\n\nMedverkande:\n\n\n\n\nAcko Ankarberg Johansson\, Sjukvårdsminister\, Regeringen\n\n\n\nBeatrice Melin\, Professor\, Umeå universitet och FoUI direktör\, Region Västerbotten\n\n\n\nRichard Rosenquist Brandell\, Professor\, Karolinska Institutet\, överläkare i klinisk genetik\, Karolinska Universitetssjukhuset och föreståndare GMS\n\n\n\nJanne Lehtiö\, Professor\, Karolinska Institutet och vetenskaplig ledare för precisionsmedicin\, SciLifeLab\n\n\n\nEva Tiensuu Janson\, Professor\, Uppsala universitet\n\n\n\nMia Phillipson\, moderator\, Professor\, Uppsala universitet och bitr. föreståndare\, SciLifeLab\n\n\n\nSuzanne Håkansson\, Chef Samhällskontakter\, AstraZeneca URL:https://www.scilifelab.se/event/hur-ska-sverige-hanga-med-i-den-snabba-globala-utvecklingen-inom-precisionsmedicin/ LOCATION:B-huset\, Campus Gotland\, Cramérgatan 3\, Visby\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/05/Almedalen-2022-platsen_JLG-1-scaled.jpg ORGANIZER;CN="SciLifeLab i Almedalen":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230630T143000 DTEND;TZID=Europe/Stockholm:20230630T153000 DTSTAMP:20260404T001422 CREATED:20230529T143449Z LAST-MODIFIED:20230620T144921Z UID:10000901-1688135400-1688139000@www.scilifelab.se SUMMARY:Pandemisk laboratorieberedskap - vad hände\, vad gör vi och vad behöver vi göra till nästa gång DESCRIPTION:SciLifeLab i Almedalen\n\n\n\nUnder Almedalsveckan 2023 arrangerar SciLifeLab ett antal seminarier för att visa hur och debattera kring hur forskning och forskningsinfrastruktur kan bidra till att möta samhälleliga utmaningar vara för att fortsatt vara en ledande life science nation.Varmt välkommen att delta! \n\n\n\nOm du vill ha kontakt med projektteamet för SciLifeLab Almedalsveckan – kontakta Per Lek \n\n\n\n \n\n\n\nBeskrivning av samhällsfrågan\n\n\n\nVi kommer att drabbas av nya pandemier och vi behöver beredskap för det. Tidigt under COVID-19 pandemin blev det uppenbart att Sverige hade begränsade resurser att analysera prover och det påverkade kontrollen av pandemin. Vad var problemen? Hur löstes dem? Vad ska vi göra till nästa pandemi? \n\n\n\nläs mer\n\n\n\nUtökad information om evenemanget:\n\n\n\nFrågor rörande pandemisk laboratorieberedskap kommer att diskuteras i ett rundabordssamtal mellan experter inom området från Folkhälsomyndigheten\, de stora mikrobiologiska laboratorierna\, SciLifeLab och universiteten som alla var iblandade i hanteringen av prover från COVID-19 infekterade patienter men även forskning som behövdes för att förstå och kunna kontrollera pandemin. Tanken är att belysa vad som av problematiskt samt vad man bör göra inför nästa pandemin\, något som vi vet kommer att ske men inte när? \n\n\n\nMedverkande:\n\n\n\n\nMia Phillipson\, Professor\, Uppsala Universitet och SciLifeLab\n\n\n\nJohan Lindh\, Docent\, Sektionschef\, Akademiska sjukhuset\n\n\n\nKarin Tegmark Wisell\, Generaldirektör\, Folkhälsomyndigheten\n\n\n\nJessica Alm\, Enhetschef\, National Pandemic Center\, Karolinska Institutet\n\n\n\nPeter Nilsson\, Professor\, KTH/SciLifeLab URL:https://www.scilifelab.se/event/pandemisk-laboratorieberedskap-vad-hande-vad-gor-vi-och-vad-behover-vi-gora-till-nasta-gang/ LOCATION:D-huset\, Campus Gotland\, Kaserngatan 1\, Visby\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/05/Almedalen-2022-platsen_JLG-1-scaled.jpg ORGANIZER;CN="SciLifeLab i Almedalen":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230730T133000 DTEND;TZID=Europe/Stockholm:20230731T140000 DTSTAMP:20260404T001422 CREATED:20230425T131158Z LAST-MODIFIED:20230516T152015Z UID:10000869-1690723800-1690812000@www.scilifelab.se SUMMARY:Advances in mRNA translation and protein synthesis DESCRIPTION:The symposium is a satellite meeting of the European Biophysical Societies’ Association conference. It will start on 30 July and finish on 31 July. The symposium will highlight the latest discoveries in the field of translation and protein synthesis. Translation occurs on ribosomes that form hubs of a proteome and nucleic acids\, which are intricate in the range of functions and their structural dynamics. Those ribosomal hubs involve multiple cofactors and are implicated in disorders\, which makes them key drug targets. Since translation requires coordination and rapid exchange between multiple factors\, tracking such a system is a laborious task. In this respect\, recent developments in imaging techniques have had a major impact on our understanding of translational systems. Therefore\, alongside presentations of biological results\, there will be methodological advances. \n\n\n\nThere will be options to present your work in a short talk or a poster. \n\n\n\nTwelve talks will be selected from abstracts submitted before June 10. Please apply for oral presentation before June 10 (extended deadline). \n\n\n\nImportant information\n\n\n\nDate: July 30 13:30 to July 31st 14:00Location: Lecture hall at BMC\, Uppsala University (more details to be announced). \n\n\n\nConference fee: The Conference fee is 650 SEK\, including dinner on July 30th and lunch on July 31st. An invoice will be sent to your Department. Payments shall be made by Departments or Organizations only (no private bank account or private address will be approved). Participants from businesses and organizations with VAT numbers within the EU can claim the VAT back from their local tax authority. More information is on the EU website.  \n\n\n\nA maximum of 60 participants will be accommodated\, with participation being confirmed on a first-come-first-serve basis. \n\n\n\nRegistration\n\n\n\n\n\n\n\n\n\n\n\nInvited speakers\n\n\n\n\n\n\n\n\n\nAxel Innis\, University of Bordeaux. \n\n\n\n\n\n\n\n\n\nDanny Nedialkova\, Max Planck Institute of Biochemistry\, Martinsried. \n\n\n\n\n\n\n\n\n\nSophia Rudorf\, Leibniz University Hannover. \n\n\n\n\n\nAxel Innis\, University of Bordeaux \n\n\n\nWe are interested in how ribosomes make proteins\, how they are regulated in response to different stimuli\, and how small molecules block these molecular machines. The focus is on the bacterial ribosome and how it is affected by nascent proteins known as arrest peptides\, antimicrobial peptides\, and antibiotics. In order to study the underlying molecular mechanisms\, we use a combination of structural biology\, high-throughput functional characterization and biochemistry. \n\n\n\nDanny Nedialkova\, Max Planck Institute of Biochemistry\, Martinsried \n\n\n\nOur research seeks to define how distinct proteomes are established and maintained in eukaryotic cells\, with the long-term goal of understanding why some cell types are selectively vulnerable to dysregulated protein homeostasis in disease. To address these questions at a systems level\, we develop and apply quantitative genome-wide techniques and combine these with functional genomics in diverse eukaryotic model systems. \n\n\n\nSophia Rudorf\, Leibniz University Hannover \n\n\n\nWe employ computational\, bioinformatic\, and mathematical approaches to model and analyze biomolecular processes. Our primary focus lies on studying protein biosynthesis across various organisms and in-vitro expression systems. \n\n\n\nOrganizers\n\n\n\nMaria Selmer\, Suparna Sanyal\, Magnus Johansson\, Uppsala University. Alexey Amunts\, SciLifeLab \n\n\n\nFor any organizational inquiries\, please contact Maria Selmer. \n\n\n\nwith support from\n\n\n\nEBSASciLifeLabEMBO URL:https://www.scilifelab.se/event/advances-in-mrna-translation-and-protein-synthesis/ CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230731T080000 DTEND;TZID=Europe/Stockholm:20230804T170000 DTSTAMP:20260404T001422 CREATED:20230224T093112Z LAST-MODIFIED:20230522T142749Z UID:10000821-1690790400-1691168400@www.scilifelab.se SUMMARY:EBSA Congress 2023 DESCRIPTION:Welcome to EBSA 2023! \n\n\n\nAn EBSA congress in Sweden is timely. In 1986\, the first EBSA Workshop was hosted by the Swedish Biophysical Society and Professor Anders Ehrenberg\, the first president of EBSA. In 2023\, after a series of great EBSA meetings around Europe\, the Swedish Society for Biochemistry\, Biophysics and Molecular Biology (SFBBM) is again\, jointly with EBSA and Protein Society\, proud to host the 14th EBSA congress at Stockholm University\, supported by the Swedish National Committee for Molecular Biosciences (of the Royal Swedish Academy of Sciences). In this meeting\, we are honored to also collaborate with the Biophysical Society\, IUPAB and SciLifeLab.In Biophysics\, we investigate properties of time\, force\, and motion in biomolecular assemblies and processes – from single molecules to cells and tissues – and relate these to biological function. Biophysics has evolved dramatically since 1986\, and many Nobel prizes have been awarded to biophysicists to previous EBSA Plenary Lecturers in the past\, and Nobel Prize winners will also participate in the upcoming congress. The EBSA-2023 will be held at the Aula Magna at Stockholm University\, which is also known for hosting the Nobel Lectures in Physics and Chemistry. \n\n\n\nEBSA-2023 will offer a creative meeting ground for investigating how the most novel experimental\, theoretical and computational approaches in Biophysics can be synergistically tailored to improve our understanding of biological function\, and thereby build an even stronger scientific bridge between physics\, biology and medicine. \n\n\n\nWe are much looking forward to learning more about your most recent findings at EBSA-2023\, and to jointly enjoy novel breakthroughs in this wide and exciting field. \n\n\n\nRead more\n\n\n\n\n\n\n\nChair \n\n\n\nDr Maria Sunnerhagen\, Professor of Structural Biology\, Linköping University \n\n\n\nCo-Chairs \n\n\n\n\nDr Erik Lindahl\, Professor of Biophysics\, Stockholm University and SciLifeLab\n\n\n\nDr Lena Mäler\, Professor of Biochemistry\, Stockholm University\n\n\n\nDr Jerker Widengren\, Professor of Biomolecular Physics\, KTH Royal Institute of Technology\, Stockholm URL:https://www.scilifelab.se/event/ebsa-congress-2023/ LOCATION:Aula Magna\, Frescativägen 6\, Stockholm\, 114 18 Stockholm\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230816T100000 DTEND;TZID=Europe/Stockholm:20230816T104500 DTSTAMP:20260404T001422 CREATED:20230621T114415Z LAST-MODIFIED:20230815T130146Z UID:10000919-1692180000-1692182700@www.scilifelab.se SUMMARY:Project support in chemical biology and drug discovery DESCRIPTION:The chemical biology unit (CBCS) and the Drug discovery and development (DDD) platform at SciLifeLab have calls out for projects. \n\n\n\nCBCS is looking for projects in Chemical Biology which includes assay development for small molecule screening and profiling\, as well as enabling chemistry. For more information\, please visit www.cbcs.se. \n\n\n\nThe DDD platform has a call looking for new project proposals for drug discovery. All therapeutic modalities that can be developed in collaboration with the DDD platform at SciLifeLab are of interest\, including small molecules\, antibodies\, oligonucleotides and new modalities. \n\n\n\nSome users and projects are at the intersection between chemical biology and drug discovery. This webinar aims to guide users to the call that best suits the needs of their project. \n\n\n\nregister here to receive link\n\n\n\nDocumentation\n\n\n\nDDD Call for Projects \n\n\n\nCBCS Large Projects Call 2023 \n\n\n\nWebinar Slides CBCS \n\n\n\nWebinar Slides DDD URL:https://www.scilifelab.se/event/project-support-in-chemical-biology-and-drug-discovery-2/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230823T080000 DTEND;TZID=Europe/Stockholm:20230824T163000 DTSTAMP:20260404T001422 CREATED:20230608T150625Z LAST-MODIFIED:20230818T114821Z UID:10000909-1692777600-1692894600@www.scilifelab.se SUMMARY:Integrated Structural Biology workshop DESCRIPTION:Structural Biology comprises studies of proteins and nucleic acids\, how they interact and how they appear in solution. The answer provides insight in to the function of the macromolecules and can explain diseases\, basic functions or be used to understand mechanisms and in the longer perspective aim in drug design to name a few of the important areas where the techniques contributes. \n\n\n\nImportant techniques for structural biology include Cryo-EM\, Nuclear Magnetic Resonance and Structural Proteomics and all of these are available through SciLifeLab. For a structural biology project\, there is a pipeline starting with the gene and the end goal information is how and where the encoded protein functions or interacts with the surround. \n\n\n\nIt has become clear over the years that no technique alone can provide a full insight into a biological problem. Thus an integrated approach where different techniques are combined is often necessary. The aim for us working with structural biology at SciLifeLab is to be a partner along the whole way\, from gene to final answer. \n\n\n\nProgram\n\n\n\nIntegrated-Structural-Biology-Workshop-1Download\n\n\n\nDay 1\n\n\n\nWe will hear from Swedish infrastructures\, covering the whole pipeline from gene to 3D protein structure and the subsequent functional analysis\, in addition to computational aspects including AlphaFold. \n\n\n\nDay 2\n\n\n\nDay 2 will contain a general overview of structural biology and available techniques. There will also be a few presentations from participants that are given the chance to discuss and get feedback on their own project from participants but also from the infrastructure representatives. We will also have a time slot to discuss the availability of infrastructures in Sweden and if there are missing parts or suggestions for changes from the users. \n\n\n\nregistration URL:https://www.scilifelab.se/event/integrated-structural-biology-workshop/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="Integrated Structural Biology Platform at SciLifeLab":MAILTO:cecilia.persson@nmr.gu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230823T090000 DTEND;TZID=Europe/Stockholm:20230824T170000 DTSTAMP:20260404T001422 CREATED:20230425T082831Z LAST-MODIFIED:20230425T083359Z UID:10000868-1692781200-1692896400@www.scilifelab.se SUMMARY:Forum for the Future of Neuroscience DESCRIPTION:What will the next 10 years of Neuroscience look like?\n\n\n\n \n\n\n\nThe global coronavirus pandemic has disproportionately affected early career researchers. This meeting is a symposium geared toward young neuroscience investigators embarking on their own research programs. Bringing together young investigators from diverse subdisciplines of neuroscience in a single venue\, where they can freely discuss the issues and future directions of their respective fields without the influence of more senior investigators\, has the potential to shape the trajectory of neuroscience in the coming decade. \n\n\n\nOn the symposium’s first day\, the event will take place at the Nobel Forum\, located close to the Karolinska Institutet in Stockholm. The Nobel Forum is where the Nobel Assembly meets to select the annual Nobel laureates in physiology or medicine \n\n\n\nOn the symposium’s second day\, the venue will shift to a more secluded location at the Swedish Collegium for Advanced Study in Uppsala. This venue\, built in 1787 to house Linneaus’s botanical collection\, is known for its peaceful and serene surroundings\, which are conducive to scholarly and intellectual pursuits. \n\n\n\n\n\n\n\nConfirmed speakers:\n\n\n\n\nJustus Kebschull JOHN HOPKINS UNIVERSITY\n\n\n\nGioele La Manno EPFL\n\n\n\nAnnegret Falkner PRINCETON UNIVERSITY\n\n\n\nTalmo Pereira SALK INSTITUTE\n\n\n\nKatharina Schmack FRANCIS CRICK INSTITUTE\n\n\n\nAshley Juavinett UNIVERSITY OF SAN DIEGO\n\n\n\nSulagna Das EMORY UNIVERSITY\n\n\n\nArkarup Banerjee CSHL\n\n\n\nNikos Konstantinides INSTITUTE JACQUES MONOD\n\n\n\nSam Golden UNIVERSITY OF WASHINGTON\n\n\n\nAlessandro Furlan KAROLINSKA INSTITUTET\n\n\n\nMarek Bartosovic STOCKHOLM UNIVERSITY\n\n\n\n\n\n\n\n\nOrganizing committee:\n\n\n\nArkarup Banerjee\, Cold Spring Harbor LaboratoryAnnegret Falkner\, Princeton UniversityAlessandro Furlan\, Karolinska InstituteDaniel Fürth\, SciLifeLab/Uppsala UniversityContact for questions: Daniel Fürthfurth@scilifelab.uu.se \n\n\n\nEvent Website: https://triplef.life/ \n\n\n\nThis event is sponsored by:\n\n\n\nMarcus Wallenberg Foundation for International Scientific CollaborationWenner-Gren FoundationsSciLifeLab URL:https://www.scilifelab.se/event/forum-for-the-future-of-neuroscience/ CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/04/Skarmavbild-2023-04-25-kl.-10.27.13.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230901T085000 DTEND;TZID=Europe/Stockholm:20230901T092500 DTSTAMP:20260404T001422 CREATED:20230822T125503Z LAST-MODIFIED:20230829T115842Z UID:10000956-1693558200-1693560300@www.scilifelab.se SUMMARY:Open online lecture by Prof. Edward Holmes: Metagenomics at the human-animal interface DESCRIPTION:The PLP (Pandemic Laboratory Preparedness) program\, started in 2021\, acts to meet society’s need for efficient use of resources\, training and education\, to propagate skills and setting up technologies and equipment to be better prepared for new pandemics. \n\n\n\nDuring the upcoming PLP program retreat\, on Friday September 1 at 08:50\, we are honored to welcome Professor Edward Holmes for an online lecture\, open for everyone to join. \n\n\n\n\n\n\n\n\n\nEdward (Eddie) Holmes is an evolutionary biologist distinguished for his work on the emergence and evolution of viruses. He has used genomic and phylogenetic approaches to reveal the major mechanisms of virus evolution and determined the genetic and epidemiological processes that explain how viruses jump species boundaries and spread in new hosts.His work has revealed the origin\, evolution and molecular epidemiology of important human pathogens including influenza\, HIV and dengue\, and enabled more accurate assessments of what types of virus are most likely to emerge in human populations and whether they will evolve human-to-human transmission. His recent research has provided fundamental insights into the breadth and biodiversity of the viral world.Eddie is currently a Professor in the School of Medical Sciences at the University of Sydney. In 2015 he was elected a Fellow of the Australian Academy of Science and in 2017 he was elected a Fellow of the Royal Society. In 2021 he received the Australian Prime Minister’s prize for science. \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nZoom link URL:https://www.scilifelab.se/event/open-online-lecture-by-prof-edward-holmes-metagenomics-at-the-human-animal-interface/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230904T151500 DTEND;TZID=Europe/Stockholm:20230904T161500 DTSTAMP:20260404T001422 CREATED:20230822T111554Z LAST-MODIFIED:20230822T112432Z UID:10000957-1693840500-1693844100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Toward Multidimensional Spectral Flow Cytometry: Entering the Quantum Cytometry Domain DESCRIPTION:J. Paul Robinson\, Professor \n\n\n\nDistinguished Professor of Cytometry \n\n\n\nProfessor of Biomedical Engineering \n\n\n\nPurdue University\, USA \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\n\n\n\n\nDr. Robinson received his early education at the University of NSW\, Sydney Australia where he received a B.Sc. (Hons)\, M.Sc. and Ph.D. degrees. He was a postdoctoral fellow in the University of Michigan Medical School then a junior faculty in the School of Pathology prior to moving to Purdue University where he was promoted to full professor in 1993. \n\n\n\nDr. Robinson is currently a Distinguished Professor of Cytometry\, and Professor of Biomedical Engineering in the Weldon School of Biomedical Engineering. He also holds appointment in the Purdue Polytechnic Institute\, School of Computer and Information Technology and IU School of Medicine. Dr. Robinson is a Fellow of the American Institute for Medical and Biological Engineering\, a Fellow of the American Association for the Advancement of Science\, a Fellow of the National Academy of Inventors and a Fellow of the Royal Microscipal Society.  Dr. Robinson is a past president of the International Society for Advancement of Cytometry and is the past Editor-in-Chief of Current Protocols in Cytometry. \n\n\n\nHe is an accomplished researcher with over 210 peer-reviewed papers\, over 400 conference presentations\, 10 books\, 15 CDs or DVDs published and over 160 invited international keynote lectures and over 20 issued patents. He formed the Purdue Cytometry Electronic Discussion list in 1989 (http://cyto.purdue.edu/hmarchiv/index.htm) and it continues today with 4500 participants. \n\n\n\nDr. Robinson is the inventor of the key patent on spectral flow cytometry that has been commercialized and morphed into one of the most significant technologies in the field of fluorescence-based single cell detection. In this regard\, together with his colleague Masanobu Yamamoto\, they recently developed the most sensitive\, highest speed single photon detector technology that is likely to have future impact on the field.  He has also worked for many years on detection technologies in the area of food borne pathogens. More recently his group has been focused on developing new approaches to toxin and pathogen detection using laser induced breakdown spectroscopy (LIBS). By combining lanthanide conjugated antibodies as target molecules for toxins\, it is possible to create a rapid detection assay that can be highly multiplexed. \n\n\n\nDr. Robinson is an accomplished mountaineer having summited several of the world’s most difficult mountains including Everest\, (8\,849m\, May 23\, 2009); Manaslu (8\,163m\, Oct 3\, 2008); and McKinley (6\,191m\, Jul 1\, 2008). In 2006 he formed the not-for-profit foundation “Cytometry for Life” (www.cytometyforlife.org) as a mechanism to promote low-cost diagnostics and education primarily in Africa and this organization continues working today to expand education and training in Africa in conjunction with AIBBC (https://www.aibbc-society.org). \n\n\n\n \n\n\n\nToward Multidimensional Spectral Flow Cytometry: Entering the Quantum Cytometry Domain\n\n\n\nFor decades flow cytometry has been a go-to technology for single cell analysis. There are clear advantages for analysis of complex suspensions of cells\, particularly when considering blood cell analysis. The principles for the latest iteration for flow cytometry technology is a spectral approach with is now 2 decades old since we first developed this approach in 2001-2003. Spectral flow cytometry has become the driving technology in the field over the past 5-7 years. What spectral cytometry has brought to the field is a vast increase in multiparameter assay capability now approaching 50 simultaneous fluorescent probes. \n\n\n\nHowever\, what we see as the future of cytometry is often based on our current view of what we presently have. And the question arises can we envisage a technology that is different from what we currently understand and use? This is a difficult question as most of us can’t exactly predict the future! What we do know is there are new tools out there that can become integrated into the field. \n\n\n\nThere is a potential for a 2nd generation spectral technology that we have been working on that may provide many more features that we currently consider when we design our experiments. This presentation will discuss the engineering developments in both current spectral analyzers and spectral cell sorters and outline the next-generation technology that will open up new frontiers in biotechnology research in both research and clinical diagnostics.  The focus will be around how do we approach quantum cytometry? Can we move from the analog world to the digital world – that is to the world where we deal with single photons – the photon being the ultimate digital event?  This requires new sensors for high-speed detection. New sensors require better optics  – more advanced diffraction approaches for light collection than currently available. High-speed sensors demand high speed electronics moving from the megahertz to the gigahertz domain. In all\, moving to quantum cytometry means redefining most of the technology that we have been using for decades.  There is a saying that “you cannot put new wine into old wine skins”! The technical demands for quantum cytometry are far more stringent that current systems allow. However\, when you meet these criteria\, the opportunities for biological detection approaches expands enormously. This presentation will outline a new sensor technology\, new laser/electronics technology and how this will generate datasets that require advanced analytical toolsets demanding AI for potentially automated diagnostics. \n\n\n\n\n\n\n\n\n\n\n\nHost: Masood Kamali-Moghaddam masood.kamali@igp.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-paul-robinson/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230906T090000 DTEND;TZID=Europe/Stockholm:20230906T170000 DTSTAMP:20260404T001422 CREATED:20230320T105854Z LAST-MODIFIED:20230901T113534Z UID:10000842-1693990800-1694019600@www.scilifelab.se SUMMARY:Emerging data-driven approaches to cancer DESCRIPTION:Welcome to the second in-person symposium in data-driven precision medicine and diagnostics (PMD) research area. Listen to leading experts in this area\, including Data-Driven Life Science (DDLS)\, and expand your network with international and national colleagues. \n\n\n\nThis meeting brings together the community in precision medicine and diagnostics and researchers who implemented artificial intelligence and machine learning applications in their research in PMD to improve human health and diagnostics\, introduces newly appointed DDLS fellows in the PMD research area\, and provides opportunities for networking across the research community and the SciLifeLab infrastructures. Thematically\, this meeting will focus on emerging approaches to cancer research\, ranging from both cutting-edge basic science to promising translational developments of AI. \n\n\n\nWe are excited to host international keynote speakers and welcome the community to join us. Hopefully\, this event will inspire you on the potentials of data-driven precision medicine and diagnostics in Sweden. \n\n\n\nTarget group: We welcome all researchers interested in the DDLS program and data-driven precision medicine and diagnostics. This is an onsite event only. The event will not be recorded as the speakers might share their unpublished results. \n\n\n\nDeadline for registration to guarantee fika and lunch: August 30. Note; to minimize food waste\, we ask you kindly to cancel your participation before August 30\, if you can´t participate. \n\n\n\nSpeakers\n\n\n\n\nAbhishek Niroula\, DDLS Fellow\, University of Gothenburg\n\n\n\nAvlant Nilsson\, DDLS Fellow\, Karolinska Institutet\n\n\n\nBeatrice Melin\, Umeå University\n\n\n\nBjörn Nilsson\, Lund University\n\n\n\nFredrik Strand\, Karolinska Institutet\n\n\n\nIda Larsson\, Uppsala University\n\n\n\nHannah Muti\, University Hospital RWTH Aachen\n\n\n\nKarin Forsberg Nilsson\, Uppsala University\n\n\n\nMichael Mints\, Weizmann Institute of Science\n\n\n\nNina Linder\, Uppsala University\n\n\n\nOlli Kallioniemi\, Director SciLifeLab and DDLS\n\n\n\nVeronica Rendo\, Uppsala University\n\n\n\n\n\n\n\n\nRegister here\n\n\n\nWhen the event is fully booked\, add yourself to the waiting list. You will be notified by email if a place becomes available. We kindly ask participants to cancel if they can´t come so the seat can become available to someone else. Thank you! \n\n\n\n\n\n\n\nProgram\n\n\n\nH:son Holmdahlsalen\, Ing 100/101\, 2 tr. Akademiska sjukhuset\, Uppsala. \n\n\n\n08:45Registration 08:45 – Please be seated at 09:1509:15Welcome and Introduction to Precision Medicine and Diagnostics Research AreaBasic science 1: Tumor heterogenetity and dynamics. Moderator: Sven Nelander\, SciLifeLab\, Uppsala University09:30Data-Driven Hallmarks (DDHMs) for Cancer Diagnostics and Precision Therapy\, Olli Kallioniemi\, SciLifeLab\, KI09:50Precision Medicine in Head and Neck Cancer Powered through Single-cell RNA Sequencing\, Michael Mints\, Weizmann Institute of Science\, Israel10:15Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers\, Ida Larsson\, Uppsala University10:35Coffee breakBasic science 2: Pushing the envelope on cancer genetics. Moderator Janne Lehtiö\, SciLifeLab\, KI10:55Genetic variation exposes regulators of hematopoietic stem and progenitor cells in vivo in humans\, Björn Nilsson\, Lund University11:15Using Evolutionary Constraint to Define Novel Candidate genes in Brain Tumors\, Karin Forsberg Nilsson\, Uppsala University11:35Understanding brain tumors; machine learning meets epidemiology\, Beatrice Melin\, Umeå University11:55Identification and exploration of toxic genes in human cancer\, Veronica Rendo\, Uppsala University12:15Lunch and network13:15DDLS Precision Medicine and Data Science Node\, Janne Lehtiö\, SciLifeLab\, KI13:25Panel discussion with all the speakers. Moderator: Janne Lehtiö\, SciLifeLab\, KIAI\, cancer\, and precision medicine. Moderator: Päivi Östling\, SciLifeLab\, KI14:05Artificial intelligence cervical cancer diagnostics at the point-of-care\, Nina Linder\, Uppsala University14:25AI for Breast Cancer Risk Prediction\, Fredrik Strand\, KI14:45The use of artificial intelligence in gastrointestinal oncology – past\, present and future\, Hannah Sophie Muti\, University Hospital Dresden\, Germany and EKFZ Institute for Digital Health\, Technical University Dresden\, Germany15:10Coffee breakDDLS Fellows session. Moderator: Åsa Johansson\, SciLifeLab\, Uppsala University15:30Pre-malignant clonal hematopoiesis stratifies risk of hematologic cancers\, Abhishek Niroula\, DDLS Fellow\, University of Gothenburg15:50A deep learning model of cellular networks\, Avlant Nilsson\, DDLS Fellow\, KI16:10Closing\, Sven Nelander\, Uppsala University 16:15The symposium ends\n\n\n\n\n\n\n\nFind your way to the Venue! \n\n\n\nEvent coordinator: Fulya Taylan\, DDLS RA coordination and Erika Erkstam\, Operations office\, SciLifeLab. \n\n\n\n\n\n\n\nMembers of The Data-driven Precision Medicine & Diagnostics expert group:\n\n\n\nGunnar Cedersund\, Linköping UniversitySven Nelander\, Uppsala UniversityLars Klareskog\, Karolinska InstitutetJohan Trygg\, Umeå UniversityPatrik Georgii-Hemming\, Karolinska InstitutetPäivi Östling\, KI (adj. SciLifeLab Precision Medicine Capability lead)Francis Lee (adj. WASP-HS representative in DDLS)David Gisselsson Nord (adjunct as GMS representant)Janne Lehtiö\, chair (DDLS SG member) \n\n\n\nAbstracts\n\n\n\nKarin Forsberg Nilsson Using Evolutionary Constraint to Define Novel Candidate Genes in Brain Tumors\nCurrent knowledge of cancer genomics remains biased against non-coding mutations. To systematically search for regulatory non-coding mutations\, we assessed mutations in conserved positions in the genome under the assumption that these are more likely to be functional than mutations in positions with low conservation. To this end\, we use whole-genome sequencing data from the International Cancer Genome Consortium (ICGC) and combined it with evolutionary constraint inferred from 240 mammals\, to identify genes enriched in non-coding constraint mutations (NCCMs)\, mutations likely to be regulatory in nature. We compare medulloblastoma (MB)\, which is malignant\, to pilocytic astrocytoma (PA)\, a primarily benign tumor\, and find highly different NCCM frequencies between the two\, in agreement with the fact that malignant cancers tend to have more mutations. In PA\, a high NCCM frequency only affects the BRAF locus\, which is the most commonly mutated gene in PA. In contrast\, in MB\, >500 genes have high levels of NCCMs. Intriguingly\, several loci with NCCMs in MB are associated with different age of onset\, such as the HOXB cluster in young MB patients. NCCMs in this locus were found to alter expression of HOXB2\, HOXB5 and HOXB9 in MB cells. In adult patients\, NCCMs occurred in e.g. the WASF-2/AHDC1/FGR locus. One of these NCCMs led to increased expression of the SRC kinase FGR\, and augmented responsiveness of MB cells to dasatinib\, a SRC kinase inhibitor. Our analysis thus points to different molecular pathways in different patient groups. These newly identified putative candidate driver genes may aid in patient stratification in MB\, and could be valuable for future selection of personalized treatment options. \n\n\n\nKarin Forsberg Nilsson is Professor of Stem Cell Research at the Department of Immunology\, Genetics and Pathology\, Uppsala\, and Dean of the Faculty of Medicine\, University. She is SciLifeLab Faculty\, and has a position as Guest Professor at the University of Nottingham\, UK. Karin Forsberg Nilsson obtained her PhD in 1992 from Uppsala University and did a postdoc 1994-1996 at the National Institutes of Health\, MD\, USA. She has held leadership positions in both pharmaceutical industry and academia. The focus of her lab is brain tumor biology and genetics. \n\n\n\n\nOlli Kallioniemi Data-Driven Hallmarks (DDHMs) for Cancer Diagnostics and Precision Therapy\nTranslating complex multi-level molecular profiling data into actionable insights for cancer diagnosis and therapy poses a formidable challenge. We propose here a paradigm for analyzing and interpreting in-depth multi-omics and functional drug response data derived from acute myeloid leukemia (AML)\, aiming at practical applications in precision clinical oncology. Our approach is based on Data-Driven Hallmarks (DDHMs)\, drawing inspiration from the Weinberg-Hanahan cancer hallmark concept (Hanahan\, 2022). While the original cancer hallmark concept provides a useful theoretical framework for understanding cancer\, it is not applicable for processing\, interpreting\, and translating molecular profiling data for precision diagnostics and therapy in individual patients. \n\n\n\nWe first acquired and integrated genomics\, transcriptomics\, epigenetics\, and proteomics data alongside ex-vivo drug response data for over 500 drugs across 150 AML samples\, resulting in nearly 100 million data points (Erkers et al.\, 2023). Subsequently\, we identified 11 dimensions of variability across the entire dataset\, referred here as DDHMs of AML. DDHMs intertwine specific multi-omics molecular features (potential diagnostic biomarkers) with distinct vulnerabilities to individual drugs (potential cancer treatments). DDHMs show proficiency in predicting high-risk AML and determining the effective drugs for each AML sample. The strategy of assembling drugs targeting active hallmarks in each patient offers a promising avenue for tailoring effective drug combinations. \n\n\n\nIn summary\, we showcase the conversion of millions of complex multi-omics research data into a manageable set of DDHMs\, which are based on specific biomarkers and linked drug vulnerabilities and provide an opportunity for tailoring drug treatments and drug combinations for individual patients. This approach aligns well with current practices and guidelines in translational\, clinical\, regulatory\, and industrial setting and could expedite bringing the benefits of data-driven precision medicine research to cancer patients. \n\n\n\nReferences: \n\n\n\n\nHanahan\, D. (2022). Hallmarks of Cancer: New Dimensions. Cancer Discov 12\, 31-46.\n\n\n\nErkers T\, Struyf N\, James T…. Orre L\, Jafari R\, Pawitan Y\, Seashore-Ludlow B\, Lehtiö J\, Lehmann S\, Östling P\, Kallioniemi O. Data-driven hallmarks of acute myeloid leukemia\, submitted\, 2023.\n\n\n\n\nOlli Kallioniemi\, M.D.\, Ph.D. is director of the Science for Life Laboratory (www.SciLifeLab.se)\, a national infrastructure for life sciences in Sweden and also a professor in Molecular Precision Medicine at the Karolinska Institutet (2015-present). He also directs the national SciLifeLab program on Data-Driven Life Science (DDLS). Olli Kallioniemi was previously the founding director of FIMM – the Institute for Molecular Medicine Finland at the University of Helsinki\, as part of the Nordic EMBL partnership in Molecular Medicine (2007-2015) Olli Kallioniemi is a member of European Molecular Biology Organization (EMBO)\, European Academy of Cancer Sciences\, the Nobel Assembly at the Karolinska Institutet and the Royal Swedish Academy of Sciences. \n\n\n\n\nIda Larsson Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers\nNervous system cancers contain a large spectrum of transcriptional cell states\, reflecting processes active during normal development\, injury response and growth. However\, we lack a good understanding of these states’ regulation and pharmacological importance. Here\, we describe the integrated reconstruction of such cellular regulatory programs and their therapeutic targets from extensive collections of single-cell RNA sequencing data (scRNA-seq) from both tumors and developing tissues. Our method\, termed single-cell Regulatory-driven Clustering (scRegClust)\, predicts essential kinases and transcription factors in little computational time thanks to a new efficient optimization strategy. Using this method\, we analyze scRNA-seq data from both adult and childhood brain cancers to identify transcription factors and kinases that regulate distinct tumor cell states. In adult glioblastoma\, our model predicts that blocking the activity of PDGFRA\, DDR1\, ERBB3 or SOX6\, or increasing YBX1 -activity\, would potentiate temozolomide treatment. We further perform an integrative study of scRNA-seq data from both cancer and the developing brain to uncover the regulation of emerging meta-modules. We find a meta-module regulated by the transcription factors SPI1 and IRF8 and link it to an immune-mediated mesenchymal-like state. Our algorithm is available as an easy-to-use R package and companion visualization tool that help uncover the regulatory programs underlying cell plasticity in cancer and other diseases. \n\n\n\nIda Larsson studied medical biotechnology at the Royal Institute of Technology in Stockholm and received her MScEng in 2018. She then continued as a PhD student in computational systems biology at Uppsala University\, where her research has focused on the brain tumor glioblastoma and developing methods for analyzing single-cell RNA sequencing data. She defended her PhD in 2023 and is now starting as a postdoctoral fellow at Dana-Farber Cancer Institute in Boston. Her research interests revolve around intratumoral heterogeneity and plasticity in neural cancers. \n\n\n\n\nNina Linder Artificial intelligence cervical cancer diagnostics at the point-of-care\nOur research group has developed and conducted proof-of-concept studies of a novel method that combines artificial intelligence (AI) and mobile digital microscopy for cell-based cervical cancer screening in resource-limited settings. The mobile microscopes are wirelessly connected via mobile networks for AI-based analysis and provide access to diagnostics where there is a lack of medical experts. We are now assessing the use of the new diagnostic method in the form of a validation studies in Kenya and Tanzania with the aim of detecting premalignant changes for the purpose of cervical cancer prevention. Cervical smears are collected at the point-of-care and digitized with mobile microscope scanners and premalignant cells detected with an AI-algorithm. Suspected abnormal cells are verified by a pathologist and treated. The method’s diagnostic accuracy\, technical feasibility\, cost and time per test\, and acceptance of the AI method is evaluated and compared to conventional diagnostics. Throughout the project\, opportunities for larger scale implementation of the diagnostic platform in East Africa are evaluated\, with the ultimate goal of achieving sustainable solutions for low-resource settings.The methods have great potential to improve equitable and sustainable access to high-quality diagnostics for cervical cancer screening among women residing in low- and middle income countries\, carrying the highest cervical cancer burden globally. \n\n\n\nNina Linder is a physician by training and received her MD and PhD from the University of Helsinki\, Finland and is an Associate Professor at Uppsala University\, Sweden as well the Institute for Molecular Medicine\, University of Helsinki\, Finland. Nina Linder’s current research involves the development of novel artificial intelligence-based solutions for cancer and infectious disease diagnostics. Linder is co-heading projects developing artificial intelligence-based tools for point-of-care diagnostics in a global setting. The overall goal of Linder’s research is to promote the implementation of innovative decision-support solutions for precision medicine to improve the translation from basic medical research to the doctor and patient at the clinic. \n\n\n\n\nBeatrice Melin Understanding brain tumors; machine learning meets epidemiology\nThe causes of glioma\, the most malignant brain tumor\, is in most cases unknown. Common environmental factors such as alcohol and smoking has not been linked to brain tumors. High doses of ionizing radiation are associated with increased risk\, but it explains very few cases. Therefore\, one assumption could be\, that glioma is an endogenous disease that is caused by a stochastic effect initiated by a complex inheritance and subsequent biological cascades leading to tumor development. To discover which biological parameters that are associated with glioma risk\, several factors need to be taken in consideration. Taking glioma as an example\, important factors when collecting data and samples and biostatistical considerations will be presented\, giving corner stones for how we have been able to harvest and find true association through data driven analyses. \n\n\n\nBeatrice Melin is MD\, PHD and Professor of Oncology at Umeå University and Director of Research Development and Innovation at Region Västerbotten. Professor Melin has worked in the field of brain tumor research for 25 years and published on both cohort\, blood tumor and registry studies. \n\n\n\n\nMichael Mints Precision Medicine in Head and Neck Cancer Powered through Single-cell RNA Sequencing\nHead and neck cancer (HNC) can be divided into two biologically distinct entities based on human papillomavirus (HPV) status. In HPV-negative HNC\, the main challenge remains finding treatments to improve survival rates and decrease recurrence\, while HPV-positive patients need better stratification methods to avoid morbidity from overtreatment. Intra-tumour heterogeneity (ITH) is a major feature in both types of HNC and a barrier to successful patient stratification and treatment. Despite its significance\, ITH remains poorly understood. \n\n\n\nWe posit that HNC tumours consist of a vast\, diverse ecosystem of cell types with different roles. In order to improve patient-tailored treatment\, our goal is to\, through single-cell RNA sequencing\, characterize these populations\, their biological and clinical significance and their roles in responses to various treatments. \n\n\n\nWe report firstly\, the identification of a novel population of cancer cells with undetectable HPV expression in HPV+ tumours. These cells are less proliferative\, more invasive and respond poorly to treatment. Validating these findings through TCGA\, we found that decreased HPV expression levels are linked to poor prognosis in HPV-positive oropharyngeal cancer. \n\n\n\nSecondly\, we show that malignant cells in HPV- oral cavity cancer express antigen-presentation genes\, and that expression of these genes together with an interferon signal across multiple cell types strongly predicts response to neoadjuvant PD-1 inhibition. \n\n\n\nFinally\, through collecting a dataset comprising > 120 HNC patients and one million cells\, we were able to find diverse recurrent cancer cell states and microenvironmental co-expression patterns. Notably\, we found a rare subset of cancer cells that undergo a full\, rather than partial epithelial-mesenchymal transition (EMT). These cells are linked to depletion of CD8+ T-cells and increased numbers of fibroblasts and macrophages in the microenvironment\, as well as poor outcomes. \n\n\n\nIn summary\, we have created a comprehensive atlas of the HNC ecosystem at previously unseen scale and resolution. We identify rare cell populations responsible for cancer hallmarks such as senescence\, proliferation and metastasis and show how subpopulations change in response to HPV infection\, radiotherapy and immunotherapy. This knowledge will greatly advance personalised treatment of head and neck cancer through guiding patient stratification\, drug development and treatment selection. \n\n\n\nMichael Mints studied medicine at Karolinska Institutet through the clinician-scientist training programme. He received his MD in 2013 and his PhD in 2015 at the Department of Oncology-Pathology. After clinical work in Umeå and a physician-researcher internship in Östersund he started a postdoc in Itay Tirosh’s lab at the Weizmann Institute in 2019. There\, his work focuses on leveraging single-cell RNA sequencing and computational methods in order to understand head and neck cancer heterogeneity with the goal of personalizing head and neck cancer treatment. \n\n\n\n\nHannah Sophie Muti The use of artificial intelligence in gastrointestinal oncology – past\, present and future\nArtificial intelligence (AI) can infer information from data in a way that exceeds human capacity to do so. Especially in clinical oncology\, scientists use AI to generate biomarkers\, find correlations or extract prognostic or predictive information. This talk will give you an idea of how it started\, how it’s going and what the future might hold for cancer researchers in an era of paradigm-shifting technological advances. \n\n\n\nHannah Muti is a Clinician/Scientist with interests in precision medicine in gastrointestinal oncology and visceral surgery. Her research covers the use of artificial intelligence to investigate gastrointestinal cancers in the context of precision oncology. She simultaneously works in the Department for Visceral\, Thoracic and Vascular Surgery at the University Hospital Dresden to obtain her specialization in visceral surgery.  \n\n\n\n\nAvlant Nilsson A deep learning model of cellular networks\nThe activity of human cells depends on interactions between molecules in molecular networks. Disruptions to these networks are common in disease\, e.g. it can drive unrestricted growth in cancer cells. Simulations of these processes could predict disease mechanisms and identify suitable drug targets. However\, these networks consist of thousands of different molecules with tens of thousands of interactions\, and it has been challenging to parametrize systems-wide models using traditional approaches. We have developed recurrent neural network models of the networks that use molecules as hidden nodes with connections constrained to known molecular interactions. These models predict unseen test-data from living cells\, e.g. we predict gene expression in macrophages in response to different ligands and we use the models to infer causative signaling cascades. Currently\, we are expanding the framework to integrate signaling\, metabolism\, and gene regulation for a more complete mechanistic description of cellular activities. \n\n\n\nAvlant Nilsson is a computational biologist and assistant professor in precision medicine at Karolinska Institutet\, Stockholm. He holds a MSc (2009-2014)\, and a PhD (2014-2019) degree in biological engineering from Chalmers University of Technology\, where his thesis focused on the metabolism of growing cells. In his postdoctoral work at Massachusetts Institute of Technology (2019-2023)\, he developed artificial neural network models to simulate signal transduction in immune cells. His new lab at Karolinska will be using these techniques to simulate cellular processes in cancer\, aiming at identifying effective drug combinations\, predicting resistance mechanisms\, and understanding cell-cell interactions in the tumor microenvironment. \n\n\n\n\nBjörn Nilsson Genetic variation exposes regulators of hematopoietic stem and progenitor cells in vivo in humans\nStem cell transplantation is a cornerstone in the treatment of blood malignancies. The most common method to harvest stem cells for transplantation is by leukapheresis\, requiring mobilization of CD34+ hematopoietic stem and progenitor cells (HSPCs) from the bone marrow into the blood. Identifying the genetic factors that control blood CD34+ cell levels could reveal new drug targets for HSPC mobilization. Here we report the first large-scale\, genome-wide association study on blood CD34+ cell levels. Across 13 167 individuals\, we identify 9 significant and 2 suggestive associations\, accounted for by 8 loci (PPM1H\, CXCR4\, ENO1-RERE\, ITGA9\, ARHGAP45\, CEBPA\, TERT\, and MYC). Notably\, 4 of the identified associations map to CXCR4\, showing that bona fide regulators of blood CD34+ cell levels can be identified through genetic variation. Further\, the most significant association maps to PPM1H\, encoding a serine/threonine phosphatase never previously implicated in HSPC biology. PPM1H is expressed in HSPCs\, and the allele that confers higher blood CD34+ cell levels downregulates PPM1H. Through functional fine-mapping\, we find that this downregulation is caused by the variant rs772557-A\, which abrogates an MYB transcription factor-binding site in PPM1H intron 1 that is active in specific HSPC subpopulations\, including hematopoietic stem cells\, and interacts with the promoter by chromatin looping. Furthermore\, PPM1H knockdown increases the proportion of CD34+ and CD34+90+ cells in cord blood assays. Our results provide the first large-scale analysis of the genetic architecture of blood CD34+ cell levels and warrant further investigation of PPM1H as a potential inhibition target for stem cell mobilization. \n\n\n\n\nAbhishek Niroula Pre-malignant clonal hematopoiesis stratifies risk of hematologic cancers\nClonal hematopoiesis (CH) is a pre-malignant condition characterized by the expansion of genetically distinct blood cell clones in healthy individuals. CH with cancer driver variations is common in the elderly population and is associated with a 10-fold higher risk of blood cancer. A number of genes recurrently mutated in CH are known (e.g.\, DNMT3A\, TET2\, and ASXL1); however\, these gene variants only account for <30% of CH clones in elderly individuals. To identify new genetic drivers of CH\, we analyzed exome sequencing data from peripheral blood samples of >50\,000 individuals. We identified CH with genetic variants in several genes previously not linked to CH. Further\, we grouped CH into myeloid and lymphoid based on the mutated genes\, which stratified the risk of incident myeloid and lymphoid malignancies. Integrating the genetic data with clinical measurements allowed identification of individuals at high risk of developing hematologic malignancies. Currently\, we are developing methods to analyze somatic variants across the whole genome to characterize CH and identify new genetic regulators of CH. \n\n\n\nI am a DDLS Fellow in precision medicine and diagnostics at the University of Gothenburg. I obtained my PhD from Lund University and did a postdoc at the Broad Institute\, Cambridge MA. My research background is on bioinformatics and human genomics\, focusing on the effects of genetic variants in human diseases including cancer. As a DDLS Fellow\, my research focuses on the study of clonal hematopoiesis (CH)\, a pre-cancer of blood. We utilize large-scale genomic data from population cohorts to understand the origin and evolution of CH and its malignant transformation. \n\n\n\n\nVeronica Rendo Identification and exploration of toxic genes in human cancer\nChromosomal gains are one of the most common somatic genetic alterations found in cancer. While the impact of sustained oncogene expression has been extensively studied\, the effects of copy number gains on “bystander” genes\, which are collaterally amplified\, remain less understood in terms of cellular fitness. To shed light on this\, we integrated the expression and copy number profiles of over 8\,000 TCGA tumors and CCLE cell lines\, along with the viability effect of gene overexpression from 17 human cancer ORF screens. Through this comprehensive and data-driven analysis\, we identified a group of genes termed ‘Amplification-Related Gain Of Sensitivity’ (ARGOS) genes. ARGOS genes are situated in frequently amplified regions of the genome\, and their expression level is reduced compared to their copy number status. However\, when overexpressed upon gain\, they prove to be toxic to the cell. Our compensation and toxicity analyses revealed five frequently amplified ARGOS genes. Notably\, one candidate showed a mechanism of toxicity involving altered DNA damage and innate immune signaling responses upon gene overexpression. This study represents a significant effort to better understand the toxicity effects associated with gene overexpression in human cancers. \n\n\n\nVeronica studied Biology at Simon Bolivar University in Venezuela\, and then moved to Sweden to pursue a PhD at Uppsala University. During this time\, she worked under the mentorship of Prof. Tobias Sjoblom and studied how genomic losses occurring in colorectal cancer can be exploited for therapy. In 2019\, she moved to Boston (USA) to pursue a postdoc in Dr. Rameen Beroukhim’s lab at Dana-Farber Cancer Institute\, affiliated with Harvard Medical School and the Broad Instititute of MIT and Harvard. Veronica’s research focused on studying therapeutic vulnerabilities associated with aneuploidy\, including predictors of resistance to clinically relevant p53 reactivation strategies in brain tumors and negative selection against amplifications in cancer. In 2023\, Veronica left the Beroukhim lab to start her own laboratory at the Department of Immunology\, Genetics and Pathology at Uppsala University. Here\, she combines descriptive and functional genomic approaches to understand how brain tumors respond and evolve during treatment. This includes continued exploration of how aneuploidy creates vulnerabilities that can be therapeutically exploited. \n\n\n\n\nFredrik Strand AI for Breast Cancer Risk Prediction\nAmong women attending screening\, 30% of their cancer is missed by current mammography-based screening. We have trained AI models to assess specific aspects of the mammography images to measure when a negative exam is less reliable. After retrospective validation we are conducting a randomized clinical trial selecting around 7% of women from screening to be offered MRI. \n\n\n\nFredrik Strand is a Swedish breast radiologist and associate professor at Karolinska Institutet\, Stockholm. He holds an MD\, PhD and MSc degrees\, and has prior experience as a strategy consultant and leading a start-up company. Fredrik is head of the research and education committee at the Swedish society of breast imaging. His academic research evolves around exploring AI for breast imaging. He and his team are involved in retrospective validation of AI algorithms\, prospective clinical trials\, and in developing new machine-learning algorithms for breast cancer detection and supplemental MRI imaging. URL:https://www.scilifelab.se/event/ddls-pmd-minisymposium-2023/ LOCATION:Martin H:son Holmdahlsalen\, Dag Hammarskjöldsväg 8\, Entrance 100\, Akademiska sjukhuset\, Uppsala CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/03/PMD_Icon.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230907T090000 DTEND;TZID=Europe/Stockholm:20230907T140000 DTSTAMP:20260404T001422 CREATED:20230821T130137Z LAST-MODIFIED:20230822T092439Z UID:10000959-1694077200-1694095200@www.scilifelab.se SUMMARY:Spatial Biology Symposium. From the Facilities to the user DESCRIPTION:Spatially resolved omics technologies (to visualize biomolecules within intact tissue specimens) have emerged during the last years. The Spatial Biology platform covers cutting-edge technologies for spatial profiling of transcripts\, proteins\, DNA\, and small molecules. Learn more about the services and capabilities that are offered from Spatial Biology Platform. Meet with researchers and national infrastructures experts from Spatial Transcriptomics\, In Situ Sequencing\, Spatial proteomics and Spatial Mass Spectrometry unit . Learn about our technologies and how other users have used to reach their goals. 10 of you will have the opportunity to visit our facilities and see the cutting-edge equipment\, meet the facility staff and discuss your potential projects. \n\n\n\nProgram\n\n\n\n09:00Registration09:10Spatial Biology overviewCharlotte Stadler09:30Spatial TranscriptomicsAnja Mezger09:50In situ sequencingKatarina Tiklova10:30Spatial ProteomicsCharlotte Stadler10:50Spatial Mass SpectrometryAnna Nilsson11:10User presentationSpatial Multimodal Analysis of Transcriptomes and Metabolomes in TissuesMarco Vicari11:30Lunch & mingle12:30Visit to Lab facilities4 groups with 5 persons max12:45Visit to Lab facilities4 groups with 5 persons max\n\n\n\nRegistration URL:https://www.scilifelab.se/event/spatial-biology-symposium-from-the-facilities-to-the-user/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="Spatial Proteomics and Spatial Transcriptomics facilities":MAILTO:carolina.oses@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230907T120000 DTEND;TZID=Europe/Stockholm:20230907T130000 DTSTAMP:20260404T001422 CREATED:20230711T112315Z LAST-MODIFIED:20230829T075641Z UID:10000925-1694088000-1694091600@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Fitz Gerald Silao & Michael Hawgood DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nFitz Gerald Silao\n\n\n\nPer Ljungdahl – alpha 3 \n\n\n\nAn acid-test of alkalization: Diverse mechanisms control amino acid-dependent environmental alkalization in Candida albicans \n\n\n\n\n\nMichael Hawgood\n\n\n\nBennie Lemmens – alpha 5 \n\n\n\nInvestigating novel inhibitors on genome instability \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-sept-7/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_124630107_HDR-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230908T100000 DTEND;TZID=Europe/Stockholm:20230908T110000 DTSTAMP:20260404T001422 CREATED:20230626T102011Z LAST-MODIFIED:20230828T055235Z UID:10000920-1694167200-1694170800@www.scilifelab.se SUMMARY:Modelling life science data in big pharma\, academia\, and startups DESCRIPTION:Join the NEW event series arranged by the SciLifeLab Data Centre focused on tools for AI/ML research in life sciences. \n\n\n\nTitle: Modelling life science data in big pharma\, academia\, and startups – Differences\, Examples\, and Some Learnings \n\n\n\nSpeaker: Andreas Bender\, Professor of Molecular Informatics\, University of Cambridge \n\n\n\nWhere and when: September 8\, 2023 at 10:00-11:00 Stockholm time\, online. Registration is open till Sept 7 at 24.00. \n\n\n\nAbstract: Life science data\, modelling methods\, and organizational environments in which they are implemented vary widely – from big pharma\, to academia\, and start-up environments (and beyond). This presentation will partly cover science and modelling\, but there will be an additional focus on the differences between the above environments (all of which the presenter has worked in)\, and how they influence the approaches\, as well as the eventual result and product to be delivered. \n\n\n\nRegister to join the event\n\n\n\nMore about the event series: \n\n\n\nTools for AI/ML research in life sciences is an event series by the SciLifeLab Data Centre aimed at life science researchers who use machine learning methods in their work. The goal of the events in this series is to provide introductions to different tools for ML research but also to foster discussions around our practices and how they can be improved. The events takes place virtually (over Zoom) and are open to researchers in Sweden and beyond. Each event is scheduled for 60 minutes\, consisting of a talk and an extended discussion. Follow the page of the event series to learn about future seminars. \n\n\n\nFor questions about the events please contact the organizing team by emailing serve@scilifelab.se \n\n\n\n \n\n\n\nScientific lead: Prof. Ola Spjuth\, SciLifeLab Data Centre and Uppsala University \n\n\n\nContact information: serve@scilifelab.se URL:https://www.scilifelab.se/event/modelling-life-science-data/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT END:VCALENDAR