BEGIN:VCALENDAR VERSION:2.0 PRODID:-//SciLifeLab - ECPv6.15.18//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:SciLifeLab X-ORIGINAL-URL:https://www.scilifelab.se X-WR-CALDESC:Events for SciLifeLab REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20250330T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20251026T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20260329T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20261025T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250113T130000 DTEND;TZID=Europe/Stockholm:20250115T140000 DTSTAMP:20260407T230219 CREATED:20240626T141219Z LAST-MODIFIED:20250109T070825Z UID:10001290-1736773200-1736949600@www.scilifelab.se SUMMARY:Evolution in Sweden 2025 DESCRIPTION:Evolution in Sweden is a biannual meeting\, which broadly gathers evolutionary biologists working in Sweden. \n\n\n\nThe meeting is aimed to be a broad meeting on every aspect of evolutionary biology and all forms of life on earth. However\, please note that the meeting is primarily (though not exclusively) for scientists active in Swedish academic departments. We also actively encourage younger researchers active in Sweden to present their research in this forum. \n\n\n\nThe Evolution in Sweden conference is organized together with the DDLS Evolution and Biodiversity research area\, within the Data-driven Life Science (DDLS) program\, part of a 12-year SEK 3.1 billion initiative from the Knut and Alice Wallenberg Foundation. We encourage researchers working with analysis of large data sets in the fields of evolution and biodiversity to attend.  \n\n\n\nStarts on January 13 at 13:00 and ends on January 15 at 14:00 \n\n\n\nVenue: Room C4\, C building\, Campus Valla\, Linköping University\, Hans Meijers väg 12\, Linköping. \n\n\n\nRegistration is from 9.30 until 13.00 outside the lecture hall on the 13th January. \n\n\n\n\n\n\n\nImportant information to participants: \n\n\n\nWelcome Reception \n\n\n\nRegistration and check-in from 09:30 to 13:00 on Monday\, January 13\, followed by lunch. Lunch is paid for by the attendees\, but we have booked a restaurant next to the venue. There is no registration fee\, but fika will be provided. Lunch\, Dinner\, and Hotel are not included in the registration. \n\n\n\nPoster presenters \n\n\n\nWe kindly ask you to hang your poster in the foyer-area outside C4 during the registration; pins will be provided. Make sure to stand by your poster during the odd or even poster session depending on your abstract/poster number. Odd abstract numbers on Jan 13 and even numbers on Jan 14. The size of each poster space is 85 x 190 cm\, so posters can be up to the standard A0 format (1189 x 841 mm) in size. \n\n\n\nOral presenters \n\n\n\nPlease upload your talk to the Dropbox directory you will be invited to in a separate email. Please ensure your presentation is uploaded by the evening before your scheduled talk. Name the file using the following format: Day_Time of your slot_Name.pdf (or .ppt). Example: Tuesday_1345_Berger.pdf. \n\n\n\nTechnical Considerations: The lecture hall computers run on Windows. If you are using a Mac\, we recommend saving your presentation in .pdf format to avoid formatting issues. A manned table will be set up near the registration desk outside the conference hall\, where you can check your presentation in advance (fonts\, animations etc). \n\n\n\nLunch \n\n\n\nThe cost of lunch is at everyone’s own expense. Lunch venue is booked at the University restaurant Kårallen\, situated in the next building down from the C-building (two minutes walk from the lecture hall). \n\n\n\nSocial activities \n\n\n\nWe have a poster session on the 13th and 14th outside the lecture theatre\, and have also highlighted a conference pub in town (O’Leary’s). This was picked because of its size\, but we don’t have any actual reservations (but it is pretty huge on the inside). It is located in the main square (Storatorget)\, and several other pubs are also located on the main square or on the next street (Ågatan) for those who want to meet for a drink in the evenings. \n\n\n\nWelcome! \n\n\n\nThe Evolution in Sweden Linköping organizing committee \n\n\n\nDominic Wright (chair)\, Rie Henriksen\, Per Jensen\, Urban Friberg and Krzysztof Bartoszek \n\n\n\nProgram\n\n\n\nProgram\n\n\n\nConference book\n\n\n\nAbstract book Evolution in Sweden 2025 v6Download\n\n\n\nRegistration\n\n\n\nRegister here\n\n\n\nTo avoid empty seats\, registration will remain open until the event begins. If we reach full capacity\, a waiting list will be activated. Sign up for the waiting list\, and you will automatically receive an email when a spot becomes available. You must accept within 24h to secure the spot. If you decline\, the offer will go to the next person on the waiting list. \n\n\n\nMake sure to cancel your registration if you cannot attend the conference. To cancel: Search for “Confirmation: Evolution in Sweden 2025” in your inbox and cancel via that Cancellation link in your individual Confirmation letter. \n\n\n\n \n\n\n\nPlenary speakers\n\n\n\nTom Gilbert – Domestication hologenomics – how did our ancestors tame the wolf?\nUniversity of Copenhagen\, Denmark \n\n\n\nComparisons of the genomes of contemporary domestic animals and plants with those of their wild relatives\, have provided a wealth of insights into not only when and where our ancestors started the process\, but also what specific genetic variants are key to modern phenotypes. Furthermore\, once coupled to palaeogenomic data\, such datasets can also even reveal the order in which such variants arose\, shedding further insights into the process itself. However\, while there is no doubt that we have learnt much about domestication in general\, and indeed for most domestic species we can clearly document the genetic basis of why the end product differs from the start\, I argue that there may be certain processes that were involved that have been largely overlooked\, in particular related to the so-called hologenome. \n\n\n\nBiography: \n\n\n\nTom Gilbert is Professor of Palaeogenomics at the University of Copenhagen\, Professor II at NTNU University Museum\, and Director of the DNRF Center for Evolutionary Hologenomics. He holds a PhD in the study of ancient DNA from the University of Oxford\, and has been active in both trying to develop methods to both expand the potential of ancient DNA to our understanding of the past\, as well as more recently leading research aimed at revisiting our understanding of ecological and evolutionary processes using hologenomic techniques – ie the integrative approach of combining host genomes with those of their microbiome. \n\n\n\n\nKees Van Oers – The epigenetics of Animal Personality\nNetherlands Institute of Ecology/ Wageningen University\, The Netherlands \n\n\n\nEpigenetic mechanisms are those molecular mechanisms that affect gene expression without changing the DNA sequence. The value of epigenetic mechanisms is increasingly recognized\, also in relation to questions in ecology and evolution. However\, epigenetic research related to behavioural variation in the natural habitat is still in its infancy. The flexible nature of epigenetic marks opens the possibility that such changes are adaptive\, while at the same time may simply be the consequence of environmental variation. Hence\, changes in epigenetic marks can function as switches in order to help an organism develop\, as signals of aging via accumulation of methylation over time\, but they also may aid organisms to cope with changing circumstances throughout their lifetime. In this presentation\, I use data of our great tit system to show examples of how tissue and cell-specific epigenetic patterns\, mainly focusing on DNA methylation\, may affect behavioral phenotypes such as exploratory behavior and reversal learning performance. I discuss what the role is of epigenetic mechanisms for behavioral adaptation to changing environments. \n\n\n\nBiography: \n\n\n\nKees van Oers is an evolutionary behavioural ecologist. He currently holds a chair in Animal Personality at Wageningen University and is senior scientist at the Netherlands Institute of Ecology (NIOO-KNAW). His research focuses on explaining the causes and consequences of individual variation in animal behaviour\, mainly cognitive and animal personality traits. He does this from an ecological and evolutionary point of view\, at the crossroads between behavioural ecology and behaviour genetics. His goal is to find answers to fundamental and strategic questions related to individual responses to changing environments. This is relevant since the world and therefore the environment is constantly changing partly due to human influences affecting biodiversity at all functional levels. \n\n\n\n\nSusan Johnston – The causes and consequences of sex differences in recombination rates.\nInstitute of Ecology and Evolution\, School of Biology\, The University of Edinburgh\, UK \n\n\n\nThe rate of meiotic recombination often shows large differences between the sexes. It can be strongly female-biased (humans)\, strongly male-biased (macaques/sheep) or somewhere in between. Understanding why this happens is key to understanding the evolution of recombination rates\, yet the causes and consequences of this phenomenon remain unknown. This talk will focus on our most recent work in house sparrows (Passer domesticus)\, with broader context from work in mammals and fish. We use genomic data in large pedigrees to characterise individual recombination rates and landscapes to: (a) investigate the heritability and genomic basis of variation in recombination rates; (b) identify genomic correlates with fine-scale sex-differences in recombination landscapes; and (c) use genomic prediction approaches to understand the relationship between recombination and fitness within each sex. Our work provides a foundation for broader understanding of the vast diversity of recombination rates in eukaryotic genomes. \n\n\n\nBiography: \n\n\n\nSusan Johnston is an evolutionary quantitative geneticist based at the University of Edinburgh\, Scotland\, where she is a Senior Lecturer and Royal Society University Research Fellow. Her research centres on using genomic information to understand selection and evolution in both wild and domesticated populations. At the moment\, her group focusses on questions related to genomic signatures of sexual conflict\, the maintenance of genetic variation in immunity\, and the causes and consequence of recombination landscape variation. She does this by taking advantage of long-term ecological datasets and deep pedigrees with genomic data in mammals\, birds and fish. \n\n\n\n\nIf you have questions\, feel free to contact the organizer\, Dominic Wright\, dominic.wright@liu.se\, Professor in Genetics\, IFM Biology\, Linköping University. Regarding DDLS-related issues\, you can ask Matthews Webster or events@scilifelab.se. URL:https://www.scilifelab.se/event/evolution-in-sweden-2025/ LOCATION:Linköping University\, Campus Valla\, Hans Meijers väg 12\, 583 29\, Linköping CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/06/EvoInSwedenSmallLogo.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250114T150000 DTEND;TZID=Europe/Stockholm:20250114T160000 DTSTAMP:20260407T230219 CREATED:20241112T105230Z LAST-MODIFIED:20250110T150619Z UID:10001401-1736866800-1736870400@www.scilifelab.se SUMMARY:SciLifeLab Lund Seminar Series | Clinical Genomics Lund DESCRIPTION:Welcome to the SciLifeLab Lund seminar series! \n\n\n\nThese seminars are designed to highlight SciLifeLab Lund\, our cutting-edge research infrastructure\, and the diverse resources available to the scientific community. \n\n\n\nIn the 3rd seminar\, we will have a in-depth look at the Center Translational Genomics (CTG) within SciLifeLab Clinical Genomics\, a research infrastructure and technical platform for Next Generation Sequencing and other genomics technologies. CTG expertise and services promote translational research projects or projects aiming at clinical implementation of new diagnostic assays in healthcare. \n\n\n\nAfter a brief introduction of the unit by Julia Bräunig\, research engineer at CTG\, Ervin Ascic (Division of Molecular Medicine and Gene Therapy at Lund University) will present his talk “Reprogramming Solid Tumors into Dendritic Cells for Cancer Immunotherapy”. \n\n\n\nPlease note that the seminars are site only but the recordings are available HERE. \n\n\n\nRegistration\n\n\n\nRegister for the next seminars!\n\n\n\n29th January 2025 | CryoEM for Life Sciences at Lund University \n\n\n\nRegister Seminar January\n\n\n\n26th February 2025 | Display and Selection Technologies \n\n\n\nRegister Seminar February\n\n\n\n26th March 2025 | Lund University Bioimaging Centre (LBIC)  \n\n\n\nRegister Seminar March\n\n\n\n23rd April 2025 | Lund Protein Production Platform \n\n\n\nRegister Seminar April\n\n\n\n28th May 2025 | National Bioinformatics Infrastructure (NBIS) \n\n\n\nRegister Seminar May\n\n\n\n18th June | Structural Proteomics \n\n\n\nRegister Seminar June URL:https://www.scilifelab.se/event/scilifelab-lund-seminar-series-ctg/ LOCATION:Belfragesalen\, BMC D15\, Klinikgatan 32\, Lund\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Lund":MAILTO:lund@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250114T150000 DTEND;TZID=Europe/Stockholm:20250114T160000 DTSTAMP:20260407T230219 CREATED:20241219T095942Z LAST-MODIFIED:20250109T104128Z UID:10001422-1736866800-1736870400@www.scilifelab.se SUMMARY:Transcription Regulation\, One Molecule at a Time DESCRIPTION:Speaker: Arnaud Krebs\, PhD\, EMBL Heidelberg \n\n\n\nAbstract\n\n\n\nTranscription factors (TFs) bind at cis-regulatory elements (CREs) such as enhancers and promoters to activate transcription. In higher eukaryotes\, chromatin presents a physical barrier that needs to be overcomedby TFs to access their DNA recognition motifs and activate transcription. Cooperativity is assumed to be a key mechanism for TFs to outcompete nucleosomes. Yet\, the contribution of individual TFs to chromatin accessibility at CREs\, and how their functions are assembled is currently not understood.   \n\n\n\nCurrent bulk assays used to map TF occupancy average binding events arising from millions of individual cells\, not informing on the potential cooperativity and the antagonisms that organize their binding at CRE. To move beyond this boundary\, we developed Single Molecule Footprinting (SMF) to quantify the binding of TFs at mouse regulatory regions.  The method allows to simultaneously measure the occurrence of multiple TFs\, nucleosomes and DNA methylation on individual molecules genome-wide.  \n\n\n\nI will illustrate how we leveraged this new layer of information to understand mechanisms of TF cooperativity and dissect the basic assembly rules used by TFs to open chromatin at CREs. Moreover\, I will elaborate on our efforts to leverage long-read sequencing to study the coordination of regulatory processes between enhancers and promoters that regulate the same gene. \n\n\n\nRelevant publications: \n\n\n\nSingle-molecule footprinting identifies context-dependent regulation of enhancers by DNA methylation. Kreibich E\,. et al. Molecular Cell. 2023 \n\n\n\nSingle molecule occupancy patterns of transcription factors reveal determinants of cooperative binding in vivo; Sönmezer\, C\, et al. Molecular Cell. 2021. \n\n\n\nStudying transcription factor function in the genome at molecular resolution. Krebs\, AR\, Trends in Genetics. 2021 \n\n\n\nBiography\n\n\n\nArnaud Krebs runs a lab in functional genomics at EMBL with a focus on the study of gene regulation mechanism.  \n\n\n\nIn his lab a new method was developed to perform single-molecule footprinting (SMF)\, a methodology to quantify protein–DNA contacts at the level of single DNA molecules and they were able to quantify the patterns of occupancy of transcription factors. The lab also revealed principles about the combinatorial action of transcription factors at regulatory regions. Using their single-molecule footprinting approach they identified that the binding of TFs on individual DNA molecules is influenced by DNA methylation.  \n\n\n\nThe lab has a strong reputation to study the multiple layers of regulatory information by developing high-throughput experimental and computational strategies. \n\n\n\n \n\n\n\nShort biosketch\n\n\n\n\nERC CoG investigator 2023.\n\n\n\nSince January 2018 – Group leader at EMBL Genome Biology Unit.\n\n\n\nAmbizione independent fellow at the FMI\, Basel\, Switzerland. \n\n\n\nPostdoctoral research at the Friedrich Miescher Institute for Biomedical Research (FMI)\, Basel\, Switzerland. Advisor: Dirk Schübeler\n\n\n\nPhD\, 2011\, IGBMC\, Strasbourg\, France. Advisor: Laszlo Tora\n\n\n\nMasters in Molecular Biology (Uni Nancy\, France) and Bioinformatics (Uni Pierre and Marie Curie\, Paris)\n\n\n\n\n\n\n\n\nThe seminar will be followed by a fika (coffee break) where young scientists (PhD students and postdocs) can meet the speaker and ask questions about the seminar and his scientific career. \n\n\n\nRegister for Meet the Speaker fika URL:https://www.scilifelab.se/event/transcription-regulation-one-molecule-at-a-time/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg ORGANIZER;CN="Spotlight Seminar Series":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250116T100000 DTEND;TZID=Europe/Stockholm:20250116T110000 DTSTAMP:20260407T230219 CREATED:20241129T082550Z LAST-MODIFIED:20241202T150108Z UID:10001410-1737021600-1737025200@www.scilifelab.se SUMMARY:Publishing Shiny apps as a researcher DESCRIPTION:Title: Publishing Shiny apps as a researcher \n\n\n\nSpeaker: SciLifeLab Data Centre team \n\n\n\nWhere and when: January 16\, 2025 at 10:00-11:00 Stockholm time\, online. Registration is open till January 16 at 9:00. \n\n\n\nAbstract: Shiny is a popular framework for building interactive web apps with visualizations\, tables\, analysis tools\, etc. using R. Researchers often create Shiny applications as part of their projects and want to publish them as supplementary materials for publications\, presentations\, and other purposes. However\, finding a venue to publish (in other words\, to host) a Shiny app is challenging because existing commercial platforms are not optimized for use by researchers and impose limitations on the speed of the applications and volume of visitors in their free tier. \n\n\n\nIn this webinar\, we will demonstrate Shiny app publication through SciLifeLab Serve — a newly developed platform that is free to use for all life science researchers in Sweden and offers dedicated resources for long-term hosting. We will discuss how to prepare a Shiny app for sharing and provide a step-by-step demonstration of how to start hosting it and obtain a public URL to share with the world. After this webinar you should be able to do this yourself for your own Shiny apps. Additionally\, we will discuss requirements from funders and research institutions when publishing Shiny applications as research output. \n\n\n\nIf you are a researcher with an existing Shiny app you’d like to publish\, or if you plan to build a Shiny app in the future\, this webinar is for you. \n\n\n\nRegister to join the event\n\n\n\nMore about SciLifeLab Serve: \n\n\n\nSciLifeLab Serve (https://serve.scilifelab.se) is a platform developed by SciLifeLab Data Centre and available free of charge to researchers affiliated with all research institutions in Sweden. The platform development is funded by the Data-Driven Life Science Programme at SciLifeLab. SciLifeLab Serve offers machine learning model serving as well as application hosting tools optimized for life science research needs\, open science principles\, and FAIR requirements. \n\n\n\nFor questions about the events please contact the organizing team by emailing serve@scilifelab.se \n\n\n\nScientific lead: Prof. Ola Spjuth\, SciLifeLab Data Centre and Uppsala University \n\n\n\nContact information: serve@scilifelab.se URL:https://www.scilifelab.se/event/publishing-shiny-apps/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250116T140000 DTEND;TZID=Europe/Stockholm:20250116T160000 DTSTAMP:20260407T230219 CREATED:20241118T134829Z LAST-MODIFIED:20250113T130421Z UID:10001403-1737036000-1737043200@www.scilifelab.se SUMMARY:NGI OpenLab Launch Event DESCRIPTION:This seminar marks the launch of NGI OpenLab\, a new lab space at SciLifeLab in Uppsala (BMC). NGI OpenLab will be a resourceful\, interactive space with equipment for quality control (QC)\, library preparation and a walk-up sequencer for on-the-go sequencing needs. \n\n\n\nOur mission is to create a collaborative environment where researchers can gain hands-on experience\, attend training sessions\, and participate in courses that deepen their skills in genomics. \n\n\n\nFollowing the seminar\, we warmly invite you to join us for a mingle session in Navet. This will be an excellent opportunity to connect with the NGI staff\, share your ideas and research needs\, and explore the newly opened NGI OpenLab space. We look forward to seeing you there! \n\n\n\nOrganizer: SciLifeLab National Genomics Infrastructure \n\n\n\nCONTACT FOR QUESTIONS: \n\n\n\nJohanna Lagensjö\, Head of Laboratory Operations\, NGI Uppsala (SNP&SEQ Technology Platform)\, johanna.lagensjo@medsci.uu.se \n\n\n\nThe registration has closed! \n\n\n\n\n\n\n\nProgram\n\n\n\n\n14:00-15:00WelcomeAristidis Moustakas & Anna Dimberg\, on behalf of the SciLifeLab-UU SFO CommitteeIntroduction to NGI services and the idea behind NGI OpenLabLars Feuk\, NGI Platform Co-DirectorNGI OpenLab in practice\, how does it work?Johanna Lagensjö\, Head of Laboratory Operations\, NGI UppsalaLibrary prep at NGI – opportunities for method development in the NGI OpenLabAmanda Raine\, Head of R&D\, NGI Uppsala15:00 and onMingle in Navet and tour to the NGI OpenLabLight snacks and drinks will be served URL:https://www.scilifelab.se/event/ngi-openlab-launch-event/ LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/11/NGI-logga.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250117T100000 DTEND;TZID=Europe/Stockholm:20250117T130000 DTSTAMP:20260407T230219 CREATED:20250107T134920Z LAST-MODIFIED:20250107T153009Z UID:10001425-1737108000-1737118800@www.scilifelab.se SUMMARY:KTH: Building and sharing machine learning demo applications DESCRIPTION:This event is open to everyone at KTH. It consists of a workshop followed by a free lunch for all participants. \n\n\n\nTitle: Building and sharing machine learning demo applications: a practical tutorial. \n\n\n\nOrganizer: KTH Library staff and AI Data Engineers from the SciLifeLab Serve team. \n\n\n\nWhere and when: January 17\, 2025 at 10:00-13:00 at KTH Library\, room Salongen\, floor 2. Address: Osquars backe 31\, Stockholm\, on the map \n\n\n\nAgenda:10:00-12:00: Workshop12:00-13:00: Lunch \n\n\n\nAbstract: It is becoming increasingly popular to share machine learning models with the community as web applications with an easy-to-use interface. Users can then adjust parameters or submit their own input and see the predictions generated by the underlying model. This tutorial is aimed at KTH researchers (all career levels welcome) who work with machine learning models but do not have the skills to build interactive applications for web. During the tutorial we will start from a trained model and demonstrate step by step how you can create a graphical user interface for your application\, prepare it for deployment\, and make it available on the web with a URL. We will demonstrate the use of specific tools which make this process easy and doable in under an hour\, specifically we will demonstrate and try out Gradio for app building. We will also demonstrate SciLifeLab Serve\, a platform for hosting models and applications available to all researchers in Sweden. \n\n\n\nLunch: After the workshop all participants are invited for lunch. During the lunch participants will have an opportunity to informally chat with KTH Library staff and SciLifeLab Data Centre to discuss the needs for services and research infrastructure in research using machine learning methods. \n\n\n\nCapacity: We have room to accept 35 participants\, on the first come first served basis. Those registered after that will be placed on the waiting list and offered a spot when someone cancels. \n\n\n\nSince there is a limited number of spots in this workshop please sign up only if you intend to attend. \n\n\n\nRegister to join the event\n\n\n\nFor questions about the events please contact the organizing team by emailing serve@scilifelab.se \n\n\n\n \n\n\n\nScientific lead: Prof. Ola Spjuth\, SciLifeLab Data Centre and Uppsala University \n\n\n\nContact information: serve@scilifelab.se URL:https://www.scilifelab.se/event/kth-building-and-sharing-machine-learning-demo-applications/ LOCATION:KTH Library\, room Salongen\, Osquars backe 31\, Stockholm\, 11428\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250123T000000 DTEND;TZID=Europe/Stockholm:20250123T235959 DTSTAMP:20260407T230219 CREATED:20250108T142522Z LAST-MODIFIED:20250108T143218Z UID:10001428-1737590400-1737676799@www.scilifelab.se SUMMARY:SciLifeLab PULSE - information webinar for applicants DESCRIPTION:This webinar (two time options available) gives PULSE applicants an opportunity to receive information on e.g. the matchmaking and application process\, as well as eligibility rules. There will also be time for Q&A:s. Find out more about the SciLifeLab PULSE postdoc program here \n\n\n\n\n\n\n\n\n\n\n\nWebinar registration\n\n\n\n\n\nWebinar on January 23\, 2025\, at 10:00 am\, UTC+1 \n\n\n\n\n\nRegister here\n\n\n\n\n\n\n\nWebinar on January 23\, 2025\, at 16:00 pm\, UTC+1 \n\n\n\n\n\nRegister here URL:https://www.scilifelab.se/event/scilifelab-pulse-information-webinars-for-applicants/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/12/AdobeStock_519582269-scaled-1.jpeg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250127T150000 DTEND;TZID=Europe/Stockholm:20250127T170000 DTSTAMP:20260407T230219 CREATED:20250110T073100Z LAST-MODIFIED:20250121T104411Z UID:10001450-1737990000-1737997200@www.scilifelab.se SUMMARY:Advancing Network Biology: The launch of FunCoup 6 DESCRIPTION:Network biology is a new paradigm to understand the complex interactions of the molecules in an organism using an integrative and systems approach. By applying network analysis in their research\, scientists can e.g. generate new hypotheses of molecular mechanisms\, perform functional annotation of network modules\, or predict new drug targets. \n\n\n\nThe comprehensive network database FunCoup (https://FunCoup.org/) is a resource that can be used to answer various research questions at the systems biology level. The new release 6 (http://www.ncbi.nlm.nih.gov/pubmed/39530220/) is a major update to the FunCoup networks and website\, which provides researchers with significantly improved capabilities for exploring the functional coupling interactome. The key innovations include: \n\n\n\n\nIncreased regulatory coverage: FunCoup 6 now includes over half a million directed gene regulatory links in the human network alone\, offering expanded insights into transcriptional regulation. \n\n\n\nIncreased coverage to 640 species in total.\n\n\n\nNew\, redesigned website with enhanced API functionalities.\n\n\n\nAdvanced integrated tools for network analysis: TOPAS for disease module identification\, ANUBIX for pathway enrichment analysis\, and Maxlink for disease gene prioritization.\n\n\n\nNew comparative interactomics search mode that queries each species network independently.\n\n\n\n\nFunCoup is also available as a Cytoscape app\, and was shown to exhibit superior performance compared to other functional association networks.  At this event\, the new FunCoup website and its unique capabilities for network exploration and analysis will be demonstrated. URL:https://www.scilifelab.se/event/advancing-network-biology-the-launch-of-funcoup-6/ LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250129T150000 DTEND;TZID=Europe/Stockholm:20250129T160000 DTSTAMP:20260407T230219 CREATED:20250122T131107Z LAST-MODIFIED:20250122T131212Z UID:10001458-1738162800-1738166400@www.scilifelab.se SUMMARY:SciLifeLab Lund Seminar Series | Cryo-EM DESCRIPTION:Welcome to the SciLifeLab Lund seminar series! \n\n\n\nThese seminars are designed to highlight SciLifeLab Lund\, our cutting-edge research infrastructure\, and the diverse resources available to the scientific community. \n\n\n\nIn the 4th seminar\, we will have a in-depth look at Cryo-EM for Life Sciences. Derek Logan\, manager at the facility\, will give an overview of the cryo-EM unit and Karin Lindkvist\, professor at Lund University\, will showcase a project carried out in collaboration with the facility. \n\n\n\nPlease note that the seminars are site only but the recordings are available HERE. \n\n\n\nRegistration\n\n\n\nRegister for the next seminars!\n\n\n\n26th February 2025 | Display and Selection Technologies \n\n\n\nRegister Seminar February\n\n\n\n26th March 2025 | Lund University Bioimaging Centre (LBIC)  \n\n\n\nRegister Seminar March\n\n\n\n23rd April 2025 | Lund Protein Production Platform \n\n\n\nRegister Seminar April\n\n\n\n28th May 2025 | National Bioinformatics Infrastructure (NBIS) \n\n\n\nRegister Seminar May\n\n\n\n18th June | Structural Proteomics \n\n\n\nRegister Seminar June URL:https://www.scilifelab.se/event/scilifelab-lund-seminar-series-cryo-em/ LOCATION:Belfragesalen\, BMC D15\, Klinikgatan 32\, Lund\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Lund":MAILTO:lund@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250130T120000 DTEND;TZID=Europe/Stockholm:20250130T130000 DTSTAMP:20260407T230219 CREATED:20250109T100021Z LAST-MODIFIED:20250127T125844Z UID:10001430-1738238400-1738242000@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Marco Vicari DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nMarco Vicari\n\n\n\nJoakim Lundeberg – alpha 3 \n\n\n\nConfirming the expression of small metabolites and lipids in FFPE samples \n\n\n\n\n\n\n\n\n\n \n\n\n\n \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-emma-bell-jakob-rosenbauer/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_120135408_HDR-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250131T110000 DTEND;TZID=Europe/Stockholm:20250131T120000 DTSTAMP:20260407T230219 CREATED:20250110T113642Z LAST-MODIFIED:20250114T131915Z UID:10001451-1738321200-1738324800@www.scilifelab.se SUMMARY:Calls for new project support in chemical biology and drug discovery DESCRIPTION:The chemical biology unit (CBCS) and the Drug discovery and development (DDD) platform at SciLifeLab have calls out for projects. \n\n\n\nCBCS is looking for projects in Chemical Biology which includes assay development for small molecule screening and profiling\, as well as enabling chemistry. For more information\, please visit www.cbcs.se. \n\n\n\nThe DDD platform has a call looking for new project proposals for drug discovery. All therapeutic modalities that can be developed in collaboration with the DDD platform at SciLifeLab are of interest\, including small molecules\, antibodies\, oligonucleotides and new modalities. \n\n\n\nSome users and projects are at the intersection between chemical biology and drug discovery. We believe this webinar will help you to find out were your project fits in best. \n\n\n\n \n\n\n\nregistration\n\n\n\nProgram: \n\n\n\n1. Presentation of CBCS offerings2. Presentation of the DDDp offerings3. Q&A \n\n\n\nOrganizer: the Chemical Biology Consortium Sweden and the Drug Discovery & Development platform URL:https://www.scilifelab.se/event/calls-for-new-project-support-in-chemical-biology-and-drug-discovery-3/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250203T080000 DTEND;TZID=Europe/Stockholm:20250204T170000 DTSTAMP:20260407T230219 CREATED:20240529T070047Z LAST-MODIFIED:20250911T092745Z UID:10001269-1738569600-1738688400@www.scilifelab.se SUMMARY:Infection Biology Across Scales DESCRIPTION:An EMBL-SciLifeLab-MIMS workshop on infection\n\n\n\nThe European Molecular Biology Laboratory (EMBL)\, SciLifeLab and the Laboratory for Molecular Infection Medicine Sweden (MIMS) invite you to an in-person workshop on infection biology on 3-4 February 2025 in Umeå.  \n\n\n\nThe workshop will focus on exploring complementary platforms and capabilities of the three organizations in light of the most important scientific challenges facing infection research. We are also eager to foster exchange between EMBL and Swedish scientists more widely\, with a particular emphasis on the next generation of future research leaders from Swedish excellence initiatives who are at a similar career stage as EMBL group leaders.  \n\n\n\nPlease join us for this one-and-a-half-day workshop to meet the researchers\, engage in discussions\, network with experts across a range of infectious disease research and related services and platforms\, accompanied by refreshments!  \n\n\n\nzoom link\n\n\n\nregister\n\n\n\nProgram\n\n\n\n3 February 2025\, Rotundan 11:30Soft landing with lunch\, Brashörnan13:00Welcome and opening wordsOliver Billker\, MIMS Director\, Jan Ellenberg\, SciLifeLab Director\, and Maria Bernabeu\, EMBL\, Infection Biology Transversal Theme13:15Session I: From pathogen genomes to pandemic preparedness  Chairs: Stefan Bertilsson\, SciLifeLab/SLU and John Lees\, Uppsala UniversityIntroductionStefan Bertilsson\, SciLifeLab/SLU and John Lees\, Uppsala University13:20Resources for assembly and annotation of metagenomes    Rob Finn\, EMBL-EBI Tools for modelling and epidemiology of pathogens John Lees\, EMBL-EBI 13:45Resolving microbial genomes in complex communities at the single-cell level  Laura Carroll\, SciLifeLab/Umeå University and MIMS 14:05Coffee Break14:20Functional annotation of malaria parasite genomes at scaleEllen Bushell\, Umeå University and MIMS14:40A Large Language Model for studying bacterial genome architecture\, population structure and epidemiologySam Horsfield\, EMBL-EBI 15:00Viral metagenomicsTobias Allander\, Karolinska Institutet/SciLifeLab15:20Meet the facilities & infrastructures  Venue: Galaxen. Coffee and cake served. 16:00Session II: Imaging infection – from organisms to structure  Chairs: Maria Bernabeu and Lars-Anders Carlson IntroductionBreaking and entering: capturing T. gondii invasion by multi-modal imaging Simone Mattei\, EMBL16:25Bioengineered models for malaria pathogenesis researchMaria Bernabeu\, EMBL16:40Resolving Enterobacterial Pathogenesis by Gut Organoid ImagingMikael Sellin\, SciLifeLab/Uppsala University16:55Coffee Break17:10Structural Biology with Neutrons at the European Spallation SourceEsko Oksanen\, European Spallation Source (ESS) and Lund University17:30Replication organelles of arboviruses through the lens of a cryo-electron microscopeLars-Anders Carlson\, Umeå University and MIMS17:50Mechanistic insight into mycobacterial Type VII SecretionMatthias Wilmanns\, EMBL 18:15Bus transfer to Bildmuseet (contemporary art museum) for social activity; guided introduction followed by walk to see exhibition 20:00Dinner in Bildmuseet\n\n\n\n4 February 2025\, Rotundan 08:30Soft landing with coffee09:00Session III: Microbiome  Chairs: Luisa Hugerth\, SciLifeLab/Uppsala University and Rob Finn\, EMBL-EBIIntroduction Leveraging large human cohorts to understand links between the gut microbiome and healthTove Fall\,  Uppsala University09:25Systems ecology of the human microbiome in health and disease: from molecules to mechanismsPaul Wilmes\, University of Luxemburg09:50Facilitating Microbial Research with High-Throughput Approaches & Automation Alexandra Koumousti\, EMBL 10:05Coffee Break10:20The effects of bugs and drugs during early lifeNele Brusselaers\, Karolinska Institutet10:35Drug resistance and metabolism of gut commensals at strain resolutionMariia Beliaeva\, EMBL   10:50Dietary suppression of Muc2-dependent host-microbiota mutualism in the small intestineGeorge Birchenough\, University of Gothenburg11:05Mechanistic insight into diet-dependent mucus modulation by the gut microbiotaBjörn Schröder\, Umeå University and MIMS  11:20Lunch  12:15Session IV: Antimicrobial resistance  Chairs: Nassos Typas and Linus Sandegren12:20Heteroresistance – a complex and insidious antibiotic resistance phenotypeDan Andersson\, Uppsala University12:45Rapid imaging-based antibiotic susceptibility testing for UTI\, sepsis\, and tuberculosisJohan Elf\, SciLifeLab/Uppsala University13:10Coffee Break13:25Breaking intrinsic antibiotic resistance by targeting bacterial defense mechanismsMichaela Wenzel\, Chalmers13:45Gut microbiota (counter)-selects for antibiotic resistant strains at a personalized mannerMichael Knopp\, EMBL14:05Reflection and Closing wordsAudience\, Session Chairs\, and Oliver Billker\, MIMS14:30Departure\n\n\n\nOrganizers\n\n\n\n\nSciLifeLab \n\n\n\nSciLifeLab Pandemic Laboratory Preparedness Capability\n\n\n\nSciLifeLab & Wallenberg National Program for Data-Driven Life Science\n\n\n\nMIMS\n\n\n\nEMBL\n\n\n\n\nCommittee\n\n\n\nMaria Bernabeu\, EMBLNassos Typas\, EMBLOliver Billker\, Nordic EMBL Partnership\, Umeå University\, MIMS\, DDLSUlf Ribacke\, Karolinska Institutet\, SciLifeLab Pandemic Laboratory Preparedness URL:https://www.scilifelab.se/event/infection-biology-across-scales-an-embl-scilifelab-mims-workshop-on-infection/ LOCATION:Rotundan\, Umeå University\, Universums Gränd 4\, Umeå\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250203T083000 DTEND;TZID=Europe/Stockholm:20250205T170000 DTSTAMP:20260407T230219 CREATED:20241014T142428Z LAST-MODIFIED:20250205T071037Z UID:10001375-1738571400-1738774800@www.scilifelab.se SUMMARY:Swedish Oikos Meeting 2025 DESCRIPTION:The Swedish Oikos Meeting 2025 will be held in Stockholm and will gather researchers and students from across Sweden to share ideas and discoveries in ecological research\, and solutions for our changing world. A diverse range of topics will be covered\, ranging from genes to ecosystems\, in Sweden and beyond. \n\n\n\nThe Planetary Biology Capability is pleased to be part of the Organization Committee and organize a special session on “Planetary Biology” \n\n\n\nCheck out the conference website to dive into the program and the invited speakers \n\n\n\nConference website\n\n\n\nPlanetary Biology pre-meeting workshop: Towards the efficient use of molecular approaches and infrastructure to accelerate research in the field of Planetary Biology\n\n\n\nThis workshop aims to enhance connections between the PB research community in Stockholm\, SciLifeLab and the Planetary Biology Capability. Discussions will address challenges and opportunities for the efficient use of SciLifeLab’s services to support and accelerate research in the field of Planetary Biology.  \n\n\n\nProgram for the session \n\n\n\n15:00 – 15:15  Introduction to the PB concept and Capability leads. \n\n\n\n15:15 – 15:45 SciLifeLab Platforms. Discussion on needs and challenges for using SciLifeLab services. \n\n\n\n15:45 – 16:00 Flagship Projects at SciLifeLab: Exploring the concept and inviting expressions of interest for collaborative development.  \n\n\n\nProgramme\n\n\n \n \n \n Powered By EmbedPress \n \n \n \n\n\nAbstract booklet\n\n\n \n \n \n Powered By EmbedPress \n \n \n \n\n\nRegister for the Planetary Biology Workshop URL:https://www.scilifelab.se/event/swedish-oikos-meeting-2025/ LOCATION:Swedish Museum of Natural History\, Frescativägen 40\, Stockholm\, Stockholm\, 114 18\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/01/PB-conference_-PBwebsite_deadlines_crop2.png ORGANIZER;CN="SciLifeLab Planetary Biology Strategic Area":MAILTO:anabella.aguilera@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250204T090000 DTEND;TZID=Europe/Stockholm:20250204T170000 DTSTAMP:20260407T230219 CREATED:20241105T151811Z LAST-MODIFIED:20250123T101457Z UID:10001398-1738659600-1738688400@www.scilifelab.se SUMMARY:Liquid biopsy-based biomarker analysis in basic research and clinical applications DESCRIPTION:The field of liquid biopsy analysis is quickly expanding across several medical and research areas. To support this growth and foster collaboration\, we invite you to an interactive seminar focused on the use of liquid biopsies in both basic research and clinical practice. \n\n\n\nEvent Highlights: \n\n\n\n\nShort presentations on various liquid biopsy analytes\, including DNA\, RNA\, and proteins.\n\n\n\nOpen slots for additional presentations of liquid biopsy projects\n\n\n\n\nDetails: \n\n\n\n\nCost: Free of charge for confirmed registrants\, including lunch and coffee breaks. However\, a no-show fee of 1000 SEK will be charged for absentees.\n\n\n\nSponsors: Wallenberg Centre for Molecular and Translational Medicine\, RISE\, Västra Götalandsregionen\, and SciLifeLab Gothenburg.\n\n\n\n\nOrganizing Committee: \n\n\n\n\nAnders Ståhlberg – Wallenberg Centre for Molecular and Translational Medicine & Sahlgrenska Center for Cancer Research\, University of Gothenburg\n\n\n\nJoakim Håkansson – RISE\n\n\n\nMaria Smedh – SciLifeLab and Core Facilities\, University of Gothenburg\n\n\n\n\nJoin us for an informative day of insights\, networking\, and knowledge-sharing! \n\n\n\nProgram: \n\n\n\nLiquid biopsy Day_2025_ProgramDownload\n\n\n\n\n\n\n\n\n\n\n\n\nRegistration\n\n\n\n\nRegistration Deadlines: \n\n\n\n\nGeneral Registration: January 21\, 2025\n\n\n\nDeadline for Talk Proposals: December 1\, 2024\n\n\n\n\nThere are limited spots available\, allocated on a first-come\, first-served basis. Once these spots are filled\, a waiting list will be implemented. \n\n\n\n\n\n\n\nThis effort and seminar day is supported by RISE\, SciLifeLab Gothenburg\, Västra Götalandsregionen and Wallenberg Centre for Molecular and Translational Medicine at University of Gothenburg. URL:https://www.scilifelab.se/event/liquid-biopsy-based-biomarker-analysis-in-basic-research-and-clinical-applications/ LOCATION:Arvid Carlsson Lecture Hall\, Sahlgrenska Academy\, University of Gothenburg\, Medicinaregatan 3\, Gothenburg\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/11/blood-grouptubes_cropped2.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250206T090000 DTEND;TZID=Europe/Stockholm:20250206T130000 DTSTAMP:20260407T230219 CREATED:20250103T141657Z LAST-MODIFIED:20250103T142337Z UID:10001424-1738832400-1738846800@www.scilifelab.se SUMMARY:AIMday Precisionsmedicin DESCRIPTION:Tid: 6 februari 2025\, 09:00-13:00Plats: Biomedicinskt centrum (BMC)\, Navet\, Husargatan 3\, entré C11\, Uppsala \n\n\n\n\n\n\n\nMain Event Website and Registration\n\n\n\n\n\n\n\nÄr du intresserad av precisionsmedicin och vill bidra till att nya lösningar utvecklas och implementeras i hälso- och sjukvården?  \n\n\n\nPrecisionsmedicinskt centrum Uppsala (PMCU) och SciLifeLab bjuder gemensamt in till AIMday Precisionsmedicin. Utifrån kliniska behov och frågeställningar inom området precisionsmedicin bjuder vi in dig som representant från hälso- och sjukvården\, akademin eller näringslivet att diskutera med oss. Vi ser fram emot att höra tankar från ditt perspektiv om hur vi skulle kunna ta oss an dessa frågeställningar tillsammans och hoppas på många inspirerande diskussioner.  \n\n\n\nAIMday är ett utbyte av kunskap och idéer\, inriktade på att hitta nya tillvägagångssätt för verkliga utmaningar. Tanken är helt enkelt att en bred blandning av kompetenser och aktörer kan ge olika perspektiv och kanske även nya vägar för att lösa utmaningar och idéer – och därigenom skapa gynnsamma förutsättningar för fortsatt samarbete mellan bland annat hälso- och sjukvården\, universitetet\, SciLifeLab och företag.  \n\n\n\nJobbar du med precisionsmedicin och vill diskutera ett behov eller frågeställning? \n\n\n\nVälkommen att anmäla dig till de frågeställningar som kommit in från hälso- och sjukvården. Sista dag för anmälan är 20 januari 2025. \n\n\n\nMain Event webiste\n\n\n\nParallella workshops kommer hållas i AIMday format (60 min per frågeställning) och du anmäler dig till den eller de frågeställningar du helst vill vara med och diskutera. Målet med dagen är att skapa förutsättningar för nya idéer och samverkansmöjligheter\, med syfte att förbättra framtidens hälso- och sjukvård inom området precisionsmedicin.  \n\n\n\nExempel på områden inom precisionsmedicin som kan diskuteras: \n\n\n\n\nPrecisionsdiagnostik \n\n\n\nPrecisionsbehandling\, tex. läkemedel och medicinteknik \n\n\n\nHälsoekonomi \n\n\n\nHälsodata \n\n\n\nAvbildningstekniker\, tex. PET \n\n\n\nAI och digitala lösningar \n\n\n\n\nAtt delta på AIMday är kostnadsfritt för alla deltagare – vi bjuder på enklare lunch.  \n\n\n\nKontakta oss om du har frågor: \n\n\n\nTherese Fagerqvist\, therese.fagerqvist@uu.seTheodora Kunovac Kallak\, theodora.kunovac_kallak@uu.seÅsa Johansson\, asa.johansson@igp.uu.seEva Berglund\, eva.berglund@scilifelab.uu.se   \n\n\n\nHär kan du läsa mer om PMCU Precisionsmedicin | Akademiska och om SciLifeLab Precision Medicine – SciLifeLab  \n\n\n\nUppsala universitet i samarbete med SciLifeLab och Precisionsmedicinskt centrum Uppsala (PMCU)  URL:https://www.scilifelab.se/event/aimday-precisionsmedicin/ LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2025/01/Header_PMCU.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250206T120000 DTEND;TZID=Europe/Stockholm:20250206T130000 DTSTAMP:20260407T230219 CREATED:20250109T100500Z LAST-MODIFIED:20250129T153638Z UID:10001431-1738843200-1738846800@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Alexandra Firsova DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nAlexandra Firsova\n\n\n\nChristos Samakovlis – gamma 4 \n\n\n\nA single cell-resolution topographic atlas of the adult human lung and its application in diseased state. \n\n\n\n\n\n\n\n\n\nErik Sonnhammer – gamma 7 \n\n\n\n \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-rekha-tripathi-mateusz-garbulowski/ LOCATION:Milkyway SciLifeLab Solna\, Tomtebodavägen 23\, Solna CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_123412496_HDR2-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250210T080000 DTEND;TZID=Europe/Stockholm:20250214T170000 DTSTAMP:20260407T230219 CREATED:20250109T134216Z LAST-MODIFIED:20250110T111623Z UID:10001449-1739174400-1739552400@www.scilifelab.se SUMMARY:Chameleon Workshop DESCRIPTION:Chameleon workshop – a practical workshop to give the opportunity to the attendants to check their own samples and start familiarising with the machine. \n\n\n\nThis is a fully practical course to give attendants the opportunity to get to know what can be obtained using the Chameleon for cryo-EM sample preparation\, how to use the machine  and give it a go with their own samples. It is organised according to the schedule below.  \n\n\n\nregistration\n\n\n\n\n\n\n\nThe first day will be open to all applicants for a presentation and a demo from the Chameleon team. The following four days will be organised in personalised training/demo sessions. We will choose 8 samples from all applications and every day we will run 2 samples with groups of maximum 4 people (due to space restraints).  If you are interested please read carefully the attached document. URL:https://www.scilifelab.se/event/chameleon-workshop/ LOCATION:SciLifeLab Campus Solna\, Tomtebodavägen 23 A\, Solna\, Sweden CATEGORIES:Course ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2025/01/Chameleon-scaled.jpg ORGANIZER;CN="Cryo-EM Infrastructure Unit":MAILTO:cryoem_stockholm_lab@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250210T151500 DTEND;TZID=Europe/Stockholm:20250210T161500 DTSTAMP:20260407T230219 CREATED:20250121T074231Z LAST-MODIFIED:20250210T140803Z UID:10001456-1739200500-1739204100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - On giant lungfish genomes and the genomics of adaptations and speciation in hyperdiverse cichlid fish radiations DESCRIPTION:Axel MeyerProfessorUniversity of Konstanz\, Germany \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nAxel Meyer (*1960 in Lübeck) studied biology at the Universities of Marburg and Kiel in Germany before he moved to the USA in 1982. At the University of California he received his Master (1985) and PhD (1988) degrees in Berkeley’s Department of Zoology. For the last year of his PhD he worked in the Biochemistry Department in lab of Allan C. Wilson at Berkeley. There he was part of a team that was the first to use PCR for questions in molecular evolution\, phylogenetics\, and ancient DNA. As an Alfred P. Sloan Postdoc he continued to work with Allan Wilson in the Biochemistry Department at Berkeley until 1990 when he became an Assistant and then (since 1993) Associate Professor in the Ecology and Evolution Department at Stony Brook\, NY. In 1997 he returned to Germany as Chair in Zoology and Evolutionary Biology at the University of Konstanz. He is a member of several academies\, including EMBO\, the Academia Europaea\, the Berlin Academy of Sciences\, the German National Academy Leopoldina\, and The American Academy of Arts and Sciences  and received a numerous awards and fellowships including Fulbright and Guggenheim Fellowships\, the Carus Medal of the Leopoldina\, and a Hector Prize. Axel Meyer’s research focuses on fundamental questions in evolutionary biology and comparative genomics with a focus on speciation\, Hox genes\, genomics of adaptations\, and gene and genome duplications. He was among the first to confirm Susumo Ohno’s suggestion that all modern fishes are derived from a lineage that experienced an additional (the teleost-specific genome duplication\, TSGD) genome duplication. Meyer received the EMBO award for communications in the life sciences for his efforts to communicate science to the public. He has a science podcast for Cicero Magazin\, wrote a popular science book on the biology of men and women\, and had a weekly column for the financial newspaper Handelsblatt. Besides Konstanz he is affiliated with the SCSIO in Guangzhou and the Museum of Comparative Zoology at Harvard University \n\n\n\nOn giant lungfish genomes and the genomics of adaptations and speciation in hyperdiverse cichlid fish radiations\n\n\n\nLungfishes are the closest living relatives to tetrapods among the “fishes”. Their genomes are the largest animal genomes\, composed of over 90% repetitive DNA\, and their size\, 3-15x larger than the human genome (~45-92Gb)\, makes them difficult to assemble and interpret. The analyses of these genomes revealed the genetics of some pre-adaptations (respiration\, locomotion\, nitrogen excretion\, olfaction) that might have permitted their relatives to conquer land in the Devonian and to give rise to all land vertebrates. While lungfishes are ancient “living fossils” that appear not have changed for >100 Million years\, the cichlid fishes of the East African Great lakes and of Nicaragua’s crater lakes have speciated and morphologically diversified at record speeds. New species formed within a few hundred generations and several phenotypic innovations evolved repeatedly and due to structural variants and transposable element activity. \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nHost: Dan Larhammar dan.larhammar@uu.se\, Per Ahlberg Per.Ahlberg@ebc.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-axel-meyer/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250211T080000 DTEND;TZID=Europe/Stockholm:20250213T170000 DTSTAMP:20260407T230219 CREATED:20250107T150231Z LAST-MODIFIED:20250207T091420Z UID:10001426-1739260800-1739466000@www.scilifelab.se SUMMARY:Basic Course in Scanning and Transmission Electron Microscopy (SEM/TEM) DESCRIPTION:This course covers lectures and practical demonstrations in SEM and TEM techniques. The contents include principles of electron microscopy\, specimen preparation\, cryo-electron microscopy and correlative light-electron microscopy. The main focus will be on imaging biological samples\, but the course may also be suitable for material scientists interested in high-resolution electron microscopy.Course overview \n\n\n\nApplication deadline:28 January 2025 \n\n\n\nLocation:Lectures at the KBC Building and laboratory demonstrations at UCEM. \n\n\n\nParticipants:18 persons \n\n\n\nInstructors:UCEM staff \n\n\n\nDuration:3 days \n\n\n\nBreaks/Refreshments:Coffee\, cookies and fruit. \n\n\n\nCosts:No course fee\, but full attendance is required! \n\n\n\nExamination/Credits:Oral and practical examinations are conducted during laboratory demonstrations. A course certificate will be given after participants attend all lectures and laboratory demonstrations for this 3-day course. UCEM recommends PhD program examiners to give 1 ECTS after successful participation. URL:https://www.scilifelab.se/event/basic-course-in-scanning-and-transmission-electron-microscopy-sem-tem-for-life-sciences-2/ LOCATION:KBC Building Umeå\, Linneaus Väg 6\, Umeå CATEGORIES:Course ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2025/01/P1010953-scaled.jpg ORGANIZER;CN="UCEM Ume%C3%A5":MAILTO:hussein.haggag@umu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250211T110000 DTEND;TZID=Europe/Stockholm:20250211T120000 DTSTAMP:20260407T230219 CREATED:20250115T125302Z LAST-MODIFIED:20251125T145533Z UID:10001454-1739271600-1739275200@www.scilifelab.se SUMMARY:Navigating the Research Data Landscape: Publication Practices at a Swedish university DESCRIPTION:Researchers are increasingly expected by governments\, funders\, journals\, and institutions to make their research data accessible online. The aim of the Swedish government is that such practices should be implemented by 2026. However\, little is known about whether\, how\, and where researchers publish or share their data. This seminar will focus on the results of a study looking at the state of open and FAIR data publication practices of Stockholm University researchers. \n\n\n\nWhen: Tuesday\, February 11 2025\, 11-12 CET (Zoom) \n\n\n\nSpeakers: Maria Almbro\, Stockholm University \n\n\n\nLink to recording on YouTube \n\n\n\nLink to presentation slides \n\n\n\nMore info\nSciLifeLab Data Management seminar series is an event series by the SciLifeLab Data Centre and NBIS joint Data Management team aimed at both the life science research community and infrastructure and others with an interest in research data management in life sciences. The events will showcase how to put the FAIR principles and good data management into practice. The goal of the events in this seminar series is to provide interesting seminars around topics related to research data management in general and to foster discussions around best practices and how they can be improved. The events take place virtually (over Zoom) and are open to everyone (researchers\, staff\, RDM professionals\, etc.) working at or affiliated with a Swedish research institute or university. Each event is scheduled for 60 minutes\, including 15 minutes for discussions and Q&A. The videos will be published openly after the seminars at the SciLifeLab YouTube channel.More information about SciLifeLab Data Centre and NBIS joint Data Management team: https://data-guidelines.scilifelab.se/ \n\n\n\nWelcome!Organisers: SciLifeLab Data Centre and NBIS National Bioinformatics Infrastructure SwedenFor more information or inquiries\, please contact: data-management@scilifelab.se URL:https://www.scilifelab.se/event/rdm-seminar-series-publication-practices/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/02/DC_seminar-series_background1-1.png ORGANIZER;CN="Open Science Seminar Series":MAILTO:data-management@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250211T123000 DTEND;TZID=Europe/Stockholm:20250211T153000 DTSTAMP:20260407T230219 CREATED:20250129T095244Z LAST-MODIFIED:20250129T140732Z UID:10001463-1739277000-1739287800@www.scilifelab.se SUMMARY:Changes and Challenges through the Ages DESCRIPTION:Be part of an empowering and enlightening discussion featuring trailblazing Women in Research as we celebrate International Day of Women and Girls in Science on February 11 at BMC\, Uppsala\, in room B7:101a. \n\n\n\nThis panel brings together accomplished research professionals to share their journeys\, challenges\, and triumphs in breaking barriers and advancing innovation. \n\n\n\nOrganizer: Vijay Sai Josyula\, Christoffersson Lab\, Uppsala University\, in cooperation with SciLifeLab Site Uppsala. \n\n\n\nGuest Speakers \n\n\n\n\nKeynote speaker. Prof. Mia Phillipson\n\n\n\nDr. Gabriela Montejo-Kovacevich\n\n\n\nDr. Kaska Koltowska\n\n\n\nDr. Jessica Nordlund\n\n\n\nDr. Amy Turner (Proteintech)\n\n\n\n\n\n\n\n\nProgram\n\n\n\n12:30             Welcome \n\n\n\n12:45             Introduction to the company Proteintech \n\n\n\n13:00             Keynote speaker Prof. Mia Phillipson \n\n\n\n13:30             Dr. Gabriela Montejo-Kovacevich \n\n\n\n13:45             Dr. Kaska Koltowska \n\n\n\n14:00             Break / Networking session \n\n\n\n14:10             Dr. Jessica Nordlund  \n\n\n\n14:25             Dr. Amy Turner\, Proteintech \n\n\n\n14:40             Panel Discussion \n\n\n\n15:30             Closing statements \n\n\n\n\n\n\n\nRegistration URL:https://www.scilifelab.se/event/changes-and-challenges-through-the-ages/ LOCATION:BMC Room B7:101a\, Husargatan 3\, Uppsala CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250212T130000 DTEND;TZID=Europe/Stockholm:20250212T140000 DTSTAMP:20260407T230219 CREATED:20250108T144537Z LAST-MODIFIED:20250108T144539Z UID:10001429-1739365200-1739368800@www.scilifelab.se SUMMARY:Biomarkers from discovery to clinical practice DESCRIPTION:Welcome to Professor Leonidas Alexopoulos‘s seminar (National Technical University of Athens and Protavio Ltd.)  \n\n\n\nwho will share his experience about diseasebiomarkers from discovery to clinical practice providing both an academic and industryperspective. \n\n\n\nWhen: February 12th 2025 at 1 pm Where: SciLifeLab\, Lunch Room Gamma-7  \n\n\n\nTranslating a multiplex biomarker discovery project to clinical practice is a comprehensive process necessitating strong research and business aptitude. As a professor in Systems Bioengineering at the National Technical University of Athens and as an entrepreneur and co-founder of Protavio\, a multiplex biomarker company using Luminex and Olink technologies\, I have seen both worlds of research and commercialization. Bridging the gap between the two worlds is of utmost importance to amplify the impact of academic research beyond traditional academic accolades such as paper citations and h-index. This talk will encapsulate insights from approximately 150 biomarker projects undertaken by Protavio in the last decade and discuss important aspects of improving the research-to-clinic biomarker translation. Several important aspects of this process will be discussed that span beyond assay development and clinical validation and include: commercialization plan\, platform selection\, software development\, stakeholder analysis\, IVDR / regulatory requirements\, reimbursement strategy\, intellectual property basics\, and stringent GMP and ISO13485 production. By understanding the importance of these elements holistically\, researchers will be in a better position to assess the commercialization potential and clinical usability of their multiplex biomarker projects. URL:https://www.scilifelab.se/event/biomarkers-from-discovery-to-clinical-practice/ LOCATION:Gamma 7 Lunchroom\, Tomtebodavägen 23A\, Solna\, 17121 CATEGORIES:Community ORGANIZER;CN="Clauida Fredolini":MAILTO:claudia.fredolini@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250213T120000 DTEND;TZID=Europe/Stockholm:20250213T130000 DTSTAMP:20260407T230219 CREATED:20250109T100715Z LAST-MODIFIED:20250204T153341Z UID:10001432-1739448000-1739451600@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Serhat Aktay & Anna Toldra Filella DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nSerhat Aktay\n\n\n\nAnniina Vihervaara – alpha 3 \n\n\n\nMapping the functional genomic landscape de novo with divergent transcription analysis of PRO-seq data \n\n\n\n\n\nAnna Toldra Filella\n\n\n\nVicent Pelechano – gamma 5 \n\n\n\nTowards point-of-care nucleic acid testing \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-serhat-aktay-eduardo-sagredo/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_124630107_HDR-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250214T100000 DTEND;TZID=Europe/Stockholm:20250214T110000 DTSTAMP:20260407T230219 CREATED:20250207T152508Z LAST-MODIFIED:20250402T084940Z UID:10001482-1739527200-1739530800@www.scilifelab.se SUMMARY:Is UMAP accurate? Addressing some fair and unfair criticism. DESCRIPTION:Nikolay Oskolkov\, NBIS\, Lund University \n\n\n\nNBIS and SciLifeLab Data Centre arrange an open SciLifeLab AI Seminar Series aimed at knowledge-sharing about Artificial Intelligence and applications in the Life Science community. The seminar series is open to everyone. The seminar is run over Zoom on the third Friday of the month during academic terms\, typically between 10 and 11 am\, with approx. 45 min presentation and 15 min discussion. \n\n\n\nAbstract \n\n\n\nUMAP is a golden standard dimensionality reduction method in single cell biology\, yet it has a controversial reputation and is sometimes heavily criticized\, see for example [1 – 5]. In particular\, the recent Nature publication of All of Us program [6] gave rise to an avalanche of discussions in scientific community regarding the controversial UMAP figure of human populations suggesting that UMAP is not accurate for this purpose. Remarkably\, the main criticism of UMAP originates (to the best of my knowledge) from the population genomics community\, wile the single cell community seems to be satisfied with the quality of UMAP analysis. \n\n\n\nIn this talk I will discuss peculiarities of data in single cell and population genomics analyses\, and explain some insights from the UMAP algorithm\, which could potentially attempt to resolve the contradiction between the two communities and very different research questions studied by the communities. I will also cover the foundations of PCA + tSNE + UMAP algorithms and emphasize their pros and cons for different types of data in Life Sciences. \n\n\n\n[1] https://simplystatistics.org/posts/2024-12-23-biologists-stop-including-umap-plots-in-your-papers/[2] https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011288[3] https://x.com/jkpritch/status/1759769445759893832?lang=en[4] https://www.nature.com/articles/d41586-024-00568-w[5] https://www.science.org/content/article/huge-genome-study-confronted-concerns-over-race-analysis[6] https://www.nature.com/articles/s41586-023-06957-x \n\n\n\nSlides \n\n\n\nDownload slides (PDF) URL:https://www.scilifelab.se/event/is-umap-accurate-addressing-some-fair-and-unfair-criticism/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250218T120000 DTEND;TZID=Europe/Stockholm:20250218T130000 DTSTAMP:20260407T230219 CREATED:20250207T145034Z LAST-MODIFIED:20250210T141259Z UID:10001478-1739880000-1739883600@www.scilifelab.se SUMMARY:Multimodal Imaging: Optimized Workflows for Improved Efficiency and Precision DESCRIPTION:This seminar talk is part of the SciLifeLab site Umeå/KBC Infrastructure Seminar series. The seminar series is held in Glasburen at KBC\, Umeå\, and online attendance is available via Zoom (link provided upon registering). \n\n\n\n\n\n\n\n\nPresenter: Cecilia Fager\, PhD\, Electron Microscopy Product and Application Specialist\, ZEISS NordicsAbstract: As the complexity of scientific questions increases\, approaches to address them are developed. One of the recent trends is the use of multimodal imaging where different microscopy techniques are used in combination to generate more detailed insights about a particular specimen. This seminar shows how multimodal imaging can be used to optimize the workflow for improved efficiency and precision. \n\n\n\nRead more and register\n\n\n\n\n\nSciLifeLab Site Umeå/KBC Infrastructure Seminar Series\n\n\n\nThis event is part of the SciLifeLab site Umeå/KBC Infrastructure Seminar series\, for future events in spring 2025\, check the seminar series home page \n\n\n\nTake me there URL:https://www.scilifelab.se/event/multimodal-imaging-optimized-workflows-for-improved-efficiency-and-precision/ LOCATION:Glasburen Seminar Room\, Chemical Biological Centre (KBC) Building\, Umeå University\, Umeå\, 901 87\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/05/SciLifeLab-Site-Umea-seminar-scaled.jpg ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250218T140000 DTEND;TZID=Europe/Stockholm:20250218T143000 DTSTAMP:20260407T230219 CREATED:20250210T114551Z LAST-MODIFIED:20250211T101325Z UID:10001483-1739887200-1739889000@www.scilifelab.se SUMMARY:CSI Seminar: Sleep Hygiene & Habits - invited talk by Ikaro Beraldo DESCRIPTION:Struggling with restless nights and low energy during the day? Sleep quality is influenced by daily habits\, not just the number of hours spent in bed. This seminar will explore the impact of routines\, environment\, and common misconceptions on sleep. Practical strategies will be discussed to improve rest\, boost focus\, and enhance overall well-being. Understanding sleep hygiene can lead to better mood\, productivity\, and long-term health. Small changes can make a big difference in achieving deeper\, more restorative sleep. \n\n\n\nWe will begin with a ~ 20 min talk\, held in Solna and over zoom. Then proceed with a reflection and discussion held only on-site. We encourage other sites to form watch parties\, by listening in together to the talk and then hold their own discussion afterwards. Hopefully seeding many local chapters of CSI. \n\n\n\nTo help facilitate discussion and reflection\, consider the following starter questions: \n\n\n\nAwareness: where do we experience sleep habits in our lives? \n\n\n\nAnalysis: how do I currently interact with sleep hygiene? \n\n\n\nAlternative: how could we relate to sleep habits\, in ourselves and others? \n\n\n\nAction: how will knowledge of sleep hygiene change my decisions going forward? URL:https://www.scilifelab.se/event/csi-seminar-sleep-hygiene-habits-invited-talk-by-ikaro-beraldo/ LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="Coaching in Science Initiative (CSI)":MAILTO:sami.saarenpaa@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250218T151500 DTEND;TZID=Europe/Stockholm:20250218T161500 DTSTAMP:20260407T230219 CREATED:20250206T124708Z LAST-MODIFIED:20250206T124825Z UID:10001479-1739891700-1739895300@www.scilifelab.se SUMMARY:In vivo site-specific engineering to reprogram human T cells DESCRIPTION:Spotlight seminar series welcomes the newly recruited SciLifeLab Fellow William Nyberg to present his research in Air&Fire Campus Solna on February 18th. \n\n\n\n\n\n\n\nWilliam Nyberg\, PhD\, is a newly appointed principal investigator at the Karolinska Institute. Building on scientific discoveries as a postdoc in Justin Eyquem’s research lab at UCSF\, his lab focuses on reprogramming T cells in vivo using advanced genetical engineering for therapeutic purposes. This is done primarily with the use of CARs\, but are also exploring the use of other synthetic receptors and therapeutic TCR sequences to develop new T cell therapies against cancers. In 2023\, he was honored with the Excellence in Research Award by the ASGCT and joined the Karolinska Institute and Science for Life Laboratory in 2024 to pursue his research. \n\n\n\nAbstract \n\n\n\nEngineered T cells\, reprogrammed to express chimeric antigen receptors (CAR) or T cell receptors (TCR)\, have transformed cancer treatment and are being explored as therapeutics for autoimmune disorders and infectious diseases. Enhancing T cell function through genome editing—either by disrupting endogenous genes or precisely inserting DNA payloads—has shown significant promise. However\, the ex vivo manufacturing process is lengthy\, costly\, and requires pre-conditioning\, limiting the accessibility of these therapies. In vivo generation of CAR-T cells could overcome these barriers. In this presentation\, I will demonstrate that stable and cell-specific transgene expression can be achieved through in vivo site-specific integration of large DNA payloads. We developed a two-vector system to deliver CRISPR-Cas9 ribonucleoproteins (RNPs) and a DNA donor template\, using enveloped delivery vehicles (EDVs) and adeno-associated virus (AAVs)\, respectively. By integrating a CAR transgene into a T cell-specific locus we generated therapeutic levels of CAR-T cells in a humanized mouse model in vivo. These findings offer a promising pathway to more efficient\, precise\, and widely accessible T cell therapies. URL:https://www.scilifelab.se/event/in-vivo-site-specific-engineering-to-reprogram-human-t-cells/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg ORGANIZER;CN="Spotlight Seminar Series":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250219T150000 DTEND;TZID=Europe/Stockholm:20250219T163000 DTSTAMP:20260407T230219 CREATED:20250205T115115Z LAST-MODIFIED:20250210T140957Z UID:10001476-1739977200-1739982600@www.scilifelab.se SUMMARY:PULSE Challenge: Properties and challenges with therapeutic oligonucleotides illustrated by hybridization-dependent off-target assessment DESCRIPTION:This presentation will describe this workflow and discuss considerations for various ONT classes\, emphasizing the importance of ONT-specific factors such as chemistry\, delivery systems\, and tissue distribution in OffT evaluation. It will also cover strategies for experimental verification and risk assessment and discuss the potential of machine learning models to enhance OffT prediction. \n\n\n\nThe seminar series PULSE Challenge is connected to the MSCA co-funded* postdoctoral program SciLifeLab PULSE\, that will train 48 future leaders in life sciences. The program focuses on innovative\, fundamental and translational research carried out in supportive and diverse academic and industrial environments\, preparing postdocs with necessary skills for long-term career sustainability. Click HERE to find out more about SciLifeLab PULSE \n\n\n\n\n\n\n\nOn-line event via Zoom \n\n\n\nRegister Here\n\n\n\n\n\n\n\n\n\n\n\n\n\nPresenter: Dr Patrik Andersson\, PhDSenior Director\, RNA Therapeutics SafetyAstraZeneca\, Gothenburg\, Sweden \n\n\n\nAbstract:Hybridization-dependent off-target (OffT) effects\, occurring when oligonucleotides bind via Watson-Crick-Franklin hybridization to unintended RNA transcripts\, remain a critical safety concern for therapeutic oligonucleotides (ONTs). Despite the importance of OffT assessment of clinical trial ONT candidates\, formal guidelines were for many years lacking\, with only brief mentions in Japanese regulatory documents (2020) and FDA recommendations for HBV (hepatitis B virus) treatments (2022). A subcommittee of the Oligonucleotide Safety Working Group (OSWG)\, was formed to gather experiences and develop updated industry recommendations for assessing OffTs of ONTs. The proposed workflow encompasses five key steps: 1) OffT identification through in silico complementarity prediction and transcriptomics analysis\, 2) focus on cell types with relevant ONT activity\, 3) in vitro verification and margin assessment\, 4) risk assessment based on the OffT biological role\, and 5) management of unavoidable OffTs. \n\n\n\nThis presentation will describe this workflow and discuss considerations for various ONT classes\, emphasizing the importance of ONT-specific factors such as chemistry\, delivery systems\, and tissue distribution in OffT evaluation. It will also cover strategies for experimental verification and risk assessment and discuss the potential of machine learning models to enhance OffT prediction. \n\n\n\nBiography:Patrik joined AstraZeneca in Gothenburg\, Sweden 2004 as “Discovery Toxicologist”\, leading the safety work from target identification to candidate selection for numerous projects. From 2012\, he developed into an expert in the safety of nucleotide-based drugs and their delivery. This includes leading the non-clinical safety work internally at AstraZeneca and in collaborations with world leading companies in the fields of antisense oligonucleotides and therapeutic mRNA. Author of several peer reviewed primary and review papers and book chapters in the area of preclinical safety assessment of oligonucleotide therapeutics and active member in several cross-industry collaboration groups. Most recently active member of the EFPIA/PDEG and IQ/DruSafe oligo working groups and leading the OSWG subcommittee that resulted in a recently accepted paper on revised industry recommendations for off-target safety assessment (DOI: 10.1089/nat.2024.0072) URL:https://www.scilifelab.se/event/pulse-challenge-properties-and-challenges-with-therapeutic-oligonucleotides-illustrated-by-hybridization-dependent-off-target-assessment/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/02/Bild1-e1770905208628.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250219T151500 DTEND;TZID=Europe/Stockholm:20250219T161500 DTSTAMP:20260407T230219 CREATED:20250210T171944Z LAST-MODIFIED:20250211T101304Z UID:10001484-1739978100-1739981700@www.scilifelab.se SUMMARY:[The Svedberg seminar]-Imaging the molecular processes of cell division across scale DESCRIPTION:Jan EllenbergProfessor Karolinska Institutet Stockholm\, Sweden and European Molecular Biology Laboratory\, Heidelberg\, Germany Director\, Science for Life Laboratory\, Sweden \n\n\n\n \n\n\n\nTHE LENNART PHILIPSON MEMORIAL LECTURE2025 \n\n\n\nLecture hall A1:107a\, BMC\, Uppsala University Wednesday\, February 19\, 2025 at 3:15 pm   \n\n\n\nBio \n\n\n\nProf. Jan Ellenberg Professor Ellenberg is renowned for his groundbreaking research in cell biology\, particularly in the areas of advanced imaging and the study of cell division. His approach of the so-called 4D dynamic change of molecular structures in living cells\, studied in individual\, and all the way into cells\, embedded in organismal tissues has generated new insight and opened immense technological potential. Dr. Ellenberg has been a group leader at the European Molecular Biology Laboratory (EMBL) since 1999\, the head of the Gene Expression Unit between 2006-2010 and the head of the Cell Biology and Biophysics Unit since 2010. He has been coordinating infrastructure development within EMBL and at the European level. Since July 2024\, Dr. Ellenberg has been acting as the Director of SciLifeLab in Sweden\, became Professor at Karolinska Institutet and an Affiliated Professor at Stockholm University and KTH Royal Institute of Technology. A single (!) representative publication out of the long series of top articles published by Ellenberg and his group highlights the essence of this year’s Lennart Philipson Memorial lecture: Gerlich D\, Ellenberg J. 4D imaging to assay complex dynamics in live specimens. Nat Cell Biol. 2003; Suppl: S14-9. Welcome! URL:https://www.scilifelab.se/event/the-svedberg-seminar-jan-ellenberg/ LOCATION:BMC Lecture hall A1:107a\, BMC\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250220T120000 DTEND;TZID=Europe/Stockholm:20250220T130000 DTSTAMP:20260407T230219 CREATED:20250109T101214Z LAST-MODIFIED:20250307T105611Z UID:10001433-1740052800-1740056400@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Xue Zhang & Elisabeth Söderberg DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nXue Zhang\n\n\n\nBennie Lemmens – alpha 5 \n\n\n\nNanoscale view on genome instability \n\n\n\n\n\nElisabeth Söderberg\n\n\n\nPer-olof Syren – gamma 5 \n\n\n\nEnzyme catalysis as a tool in monomer synthesis \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-xue-zhang-elisabeth-soderberg/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/12/IMG_4110-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT END:VCALENDAR