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DTSTART;TZID=Europe/Stockholm:20231031T130000
DTEND;TZID=Europe/Stockholm:20231031T160000
DTSTAMP:20260403T234751
CREATED:20231010T074915Z
LAST-MODIFIED:20231020T074900Z
UID:10000996-1698757200-1698768000@www.scilifelab.se
SUMMARY:I Forskningens Framkant - Fortbildning för Gymnasielärare
DESCRIPTION:Välkommen till en fortbildning där du får uppleva delar av det nationella forskningscentret för molekylära biovetenskaper i Stockholm. \n\n\n\nDenna eftermiddag får du möta fyra forskare som berättar om sin forskning och så gör vi en rundvandring på SciLifelab. Fortbildningen avslutas med mingel med tilltugg. \n\n\n\nProgram12:30-13:00 Kaffe13:00-14:30 Föreläsningar – fyra forskare från SciLifeLab14:30-15:00 Visning av labb15:00-16:00 Mingel med tilltugg \n\n\n\nPlats: SciLifeLab\, Tomtebodavägen 23\, SolnaKarta: Google Maps \n\n\n\nVälkommen med din anmälan! \n\n\n\nRegistrering\n\n\n\nFrom Genes to Proteins: The Power of the Human Protein AtlasFredrik Edfors\, SciLifeLab/KTHFramtidens målsökande läkemedelStefan Ståhl\, SciLifeLab/KTHKlinisk GenomikAnna Lyander\, SciLifeLab/Karolinska InstitutetMikrobernas samhällenAnders Andersson\, SciLifeLab/KTH14:00-15:00 Rundvandring i lokalerna15:00-16:00 Mingel med tilltugg \n\n\n\n \n\n\n\nFrom Genes to Proteins: The Power of the Human Protein AtlasFredrik Edfors\, SciLifeLab/KTH \n\n\n\nHuman Protein Atlas (HPA) som finansieras av Knut och Alice Wallenbergs stiftelse är ett svenskt projekt som är baserat på SciLifeLab\, en nationell samarbetsplattform för molekylär biologi som drivs av KTH\, Karolinska Institutet\, Stockholms universitet och Uppsala universitet. Människan har cirka 20 000 gener som kodar för proteiner\, och HPA hjälper till att identifiera olika kombinationer av proteiner som är avgörande för mänsklig biologi. HPA strävar efter att systematiskt kartlägga det mänskliga genomet på proteinnivå och på www.proteinatlas.org presenteras dessa nivåer inom flera olika fokusområden. Dessa inkluderar bland annat inkluderar proteinuttryck i vävnader\, hjärna\, cell-linjer eller nivåer blod och hur dessa skiljer sig mellan olika sjukdomstillstånd. Förutom att stödja andra forskare är atlasen också en värdefull utbildningsresurs för ämnen som rör den mänskliga kroppen\, cellbiologi och molekylärbiologi.  \n\n\n\nFramtidens målsökande läkemedelStefan Ståhl\, SciLifeLab/KTH \n\n\n\nSmå bindarproteiner kan med hjälp av riktad evolution fås att binda till sjukdomsrelaterade proteiner\, så kallade biomarkörer\, som kan utnyttjas som måltavlor för nya typer av proteinläkemedel. Som exempel kan cancertumörceller målsökas på detta sätt. Dessa målsökande bindarproteinerna kan “beväpnas”\, t.ex. med cellgifter eller lämpliga radioisotoper som dödar tumörcellerna\, med minimal påverkan på frisk vävnad. \n\n\n\nKlinisk GenomikAnna Lyander\, SciLifeLab/Karolinska Institutet \n\n\n\nClinical Genomics är en infrastrukturplattform vid Scilifelab. Plattformen arbetar med avancerade genomikmetoder\, olika typer av sekvenseringsteknologier och dataanalysverktyg\, för att stötta forskning och sjukvård. Clinical Genomics erbjuder en helhetslösning inom next generation sequencing för translationella forskningsprojekt och kliniska studier\, och bidrar till att optimera tekniker så att de kan användas inom precisionsmedicin. Plattformen arbetar också inom ramen för Genomic Medicine Sweden för att harmonisera precisionsmedicin i Sverige vilket banar väg för bättre diagnostik\, vård och behandling i hela landet. \n\n\n\nMikrobernas samhällenAnders Andersson\, SciLifeLab/KTH
URL:https://www.scilifelab.se/event/i-forskningens-framkant-fortbildning-for-gymnasielarare/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231026T120000
DTEND;TZID=Europe/Stockholm:20231026T130000
DTSTAMP:20260403T234751
CREATED:20230711T115158Z
LAST-MODIFIED:20231010T083550Z
UID:10000932-1698321600-1698325200@www.scilifelab.se
SUMMARY:Campus Solna Seminar Series: Stavros Azinas & Marco Grillo
DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an  initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nStavros Azinas\n\n\n\nMarta Carroni – gamma 3 \n\n\n\nConformational insights of bacterial dissagregase CLPG \n\n\n\n\n\nMarco Grillo\n\n\n\nMats Nilsson – gamma 4 \n\n\n\nOpen source tools for high-throughput spatially resolved transcriptomics \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
URL:https://www.scilifelab.se/event/campus-solna-seminar-series-oct-26/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/12/IMG_4110-scaled.jpg
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231025T080000
DTEND;TZID=Europe/Stockholm:20231027T130000
DTSTAMP:20260403T234751
CREATED:20230814T082817Z
LAST-MODIFIED:20231019T092918Z
UID:10000950-1698220800-1698411600@www.scilifelab.se
SUMMARY:Subtomogram averaging workshop for cryo electron tomography
DESCRIPTION:Cryoelectron tomography is anemerging field in structural biology. We are happy to announce that we are hosting a Subtomogram averaging workshop for cryo electron tomography\, taking place on 25-27 October 2023 at Stockholm University.  \n\n\n\nThe aim of the course is to provide training in Subtomogram averagingusing e.g. Dynamo and Relion4 including the latest developments of the field. \n\n\n\nRegistration is now closed \n\n\n\nThe workshop provides hands-on training in all practical aspects of tomography and sub-tomogram averaging using the Dynamo software\, encompassing all stages of the pipeline: alignment and reconstruction of tilt series\, tomogram visualization and archiving\, particle selection and extraction\, and subtomogram alignment\, averaging\, refinement and classification. No previous experience is required. Computing infrastructure will be provided in place\, and we welcome participants to bring their own data sets to work on them during this two-day course. \n\n\n\n\n\n\n\nParticipants will be selected on the basis of applications that describe their current research projects and plans. Priority will be given to participants that are currently processing their own cryo-ET data and are users of the SciLifeLab cryo-EM facilities. \n\n\n\nDeadline for application:  15 September 2023  \n\n\n\nNotification: Applicants will be notified of the outcome of their application by 20 September 2023 \n\n\n\nCourse fee payment deadline: 30 September 2023 \n\n\n\nThe registration fee: 1000 SEK and includes \n\n\n\n\nAttendance in the course 25-27 October 2023\n\n\n\nLunches\, coffee and refreshments on the course dates\n\n\n\nCourse materials\n\n\n\nCertificate of attendance\n\n\n\nCourse dinner on first night of the course\n\n\n\n\nPlease note\, the registration fee does not cover hotel\, travel expenses\, breakfasts\, and dinners (expect the course dinner second night) \n\n\n\nCourse Content\n\n\n\nThe course content can be found here \n\n\n\nRead more\n\n\n\nAs a general guideline\, we will cover: \n\n\n\n\nAlignment and reconstruction of tilt series.\n\n\n\nManual and automated particle picking in different geometries (filaments\, membranes\, isolated particles…).\n\n\n\nArchiving and cataloguing of tilt series\, tomograms and annotations.\n\n\n\nCreation of subtomogram averaging projects.\n\n\n\nAdvanced tools in subtomogram averaging.\n\n\n\nClassification methods.\n\n\n\nCreation of 3d scenes.\n\n\n\nScripting in Dynamo: gentle introduction to programming.\n\n\n\n\nComputing facilities\n\n\n\nComputer room at KÖL\, Stockholm University \n\n\n\nVenues \n\n\n\n25-26/10-23 \n\n\n\nDepartment of Biochemistry and BiophysicsComputer room at KÖL\, K343Stockholm University\, Svante Arrhenius väg 16CStockholm \n\n\n\n27/10-23 \n\n\n\nSciLifeLab Seminar room in building gamma 2\, Air&Fire Tomtebodavägen 23ASolna \n\n\n\n \n\n\n\nProgram\n\n\n\nProgram_231018_1Download
URL:https://www.scilifelab.se/event/subtomogram-averaging-workshop-for-cryo-electron-tomography/
LOCATION:Arrhenius Laboratory\, Stockholm University\, Svante Arrhenius väg 16C\, Stockholm
CATEGORIES:Course
ORGANIZER;CN="Cryo-EM Infrastructure Unit":MAILTO:cryoem_stockholm_lab@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231024T090000
DTEND;TZID=Europe/Stockholm:20231024T190000
DTSTAMP:20260403T234751
CREATED:20231018T073920Z
LAST-MODIFIED:20231024T071000Z
UID:10001002-1698138000-1698174000@www.scilifelab.se
SUMMARY:SciLifeLab Campus Solna Science Talks
DESCRIPTION:We would hereby like to warmly welcome you to take part in this year’s Campus Solna Science Talks symposium on October 24th – a meeting for everyone in the community to learn more about ongoing research and activities at SciLifeLab’s Campus Solna\, which aims to bring the community together\, inspire exchange and new collaborations. \n\n\n\nResearch presentations will be given by group leaders and junior researchers (selected with consideration for balance in topics\, presenters’ career stages\, and affiliations) as part of a plenary session between 9:00 and 16:00 (including lunch)\, and the event will conclude with a poster session\, mingle and food in Campus Solna’s meeting place Delta.  \n\n\n\nWe invite all Campus Solna research groups to be represented with at least 1 poster (and maximum 3). Furthermore\, we want to encourage all infrastructure units and committees (The Diversity\, Equity and Inclusion-committee\, the Public Engagement-committee\, the CSI and the PhD- & Postdoc-council) to partake with posters! \n\n\n\nList of Posters (titles & numbering) \n\n\n\n\n\n\n\n \n\n\n\n\n\n\n\nProgram\n08:30Arrival\, registration and coffeeJacob Berzelius hall\, Karolinska Institutet09:00Welcome and opening of symposiumScientific Committee & Per LjungdahlSession I. Moderator Yerma Pareja09:15Mapping B and T cell receptors using spatial transcriptomicsCamilla Engblom09:30Use the Flow\, Leukocyte: ion and water fluxes are required for T cell migrationLeon de Boer09:45B cell repertoire analysis of SARS-CoV-2-infected individualsGunilla Karlsson Hedestam10:15Coffee BreakSession II. Moderator Marcel Tarbier10:45agoTRIBE detects microRNA-target interactions transcriptome-wide in single cellsVaishnovi Sekar11:00Single cell-resolution in situ sequencing elucidates spatial dynamics of multiple sclerosis lesion and disease evolutionChristoffer Mattsson Langseth11:15Beyond the host’s spatial transcriptomeStefania Giacomello11.30Machine learning of immune escape dynamics from single cell and spatial tumor transcriptomicsJakob Rosenbauer11.45LunchSession III. Moderator Ute Hoffmann13:00Female sex hormones and the human microbiomeLuisa Hugherth13:15Environmental genomics for broadscale studies on aquatic microbial diversity and evolutionKrzysztof Jurdzinski13:30Interaction proteomics to explore protein regulation in photosynthetic organismsAnna Karlsson13:45Developmental Gene TranscriptionMattias Mannervik14:15Coffee BreakSession IV. Moderator Erdinc Sezgin14:45Modelling Glut1 Deficiency Syndrome (Glut1DS) for therapeutics and drug discoveryRekha Tripathi15:00Multiplexed high-content screening of drug and immune sensitivity in microwellsValentina Carannante15:15Dynamics at the molecular scale from cells to STARSSIlaria Testa15:45Concluding RemarksPer Ljungdahl16:00Poster SessionSciLifeLab DeltaMingle\, pub and light food\n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\n\nPoster Session\nEach group/unit is welcome to bring up to 3 posters to the grand Poster Session that will follow the talks. Submit the poster titles in the registration form. Please coordinate within your research group/unit beforehand who should bring a poster. Poster session will take place in the Delta building in SciLifeLab Solna. \n\n\n\nPoster dimensions: 70×100 \n\n\n\n \n\n\n\n\n\n\n\n\nScientific Committee\nThis event has been made possible through the hard work of the Scientific committee. \n\n\n\nScientific Committee \n\n\n\n\nErdinc Sezgin\n\n\n\nMarcel Tarbier\n\n\n\nUte Hoffman\n\n\n\nStefania Giacomello\n\n\n\nKristoffer Sahlin\n\n\n\nPer Ljungdahl\n\n\n\n\nOperations Office representatives \n\n\n\n\nIsolde Palombo\n\n\n\nDisa Larsson Hammarlöf
URL:https://www.scilifelab.se/event/scilifelab-campus-solna-science-talks-2/
LOCATION:Jacob Berzelius salen\, KI\, Berzelius väg 3\, Solna\, 171 65\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/07/181A6885-Danish-Saroee_frikopt-scaled.jpg
ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231023T151500
DTEND;TZID=Europe/Stockholm:20231023T161500
DTSTAMP:20260403T234751
CREATED:20231006T134540Z
LAST-MODIFIED:20231006T140206Z
UID:10000993-1698074100-1698077700@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Peptide nucleic acid (PNA)-mediated pretargeting for radionuclide therapy
DESCRIPTION:Amelie Karlström \n\n\n\nProfessor of Molecular BiotechnologyDepartment of Protein Science\, KTH \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nAmelie Eriksson Karlström is Professor of Molecular Biotechnology at the Department of Protein Science\, KTH\, where her research group is focused on protein engineering\, affinity technologies and bioconjugation chemistry for diagnostic and therapeutic applications. Amelie Eriksson Karlström has a background in solid phase peptide synthesis methodology from PhD studies at the Department of Neurochemistry and Neurotoxicology at Stockholm University. She did postdoctoral studies at the Scripps Research Institute\, La Jolla\, CA\, working on catalytic antibodies and display technologies with Profs. Richard A. Lerner and Carlos Barbas\, III\, before starting her independent research at KTH \n\n\n\n \n\n\n\nPeptide nucleic acid (PNA)-mediated pretargeting for radionuclide therapy\n\n\n\nTargeted radionuclide therapy utilizes tumor-specific radiolabeled molecules to deliver cytotoxic radiation to tumor cells. To avoid unwanted exposure of non-tumor organs\, a pretargeting strategy can be used\, where the tumor-targeting step is uncoupled from the delivery of the toxic radionuclide. The primary agent is administered first and the secondary\, radiolabeled agent is administered after the primary agent has accumulated in the tumor and cleared from non-tumor tissue. We have developed and evaluated a system for pretargeting based on the high selectivity and high affinity of peptide nucleic acid (PNA) hybridization. We have demonstrated that the PNA-based pretargeting system gives high tumor-to-normal tissue contrast in vivo both using affibody molecules and monoclonal antibodies as the tumor-targeting agents.  \n\n\n\nIn this seminar\, the molecular design and technological aspects of the PNA-based pretargeting system will be discussed. Results from preclinical evaluation of the PNA-based pretargeting strategy will be presented.  \n\n\n\n \n\n\n\n\n\n\n\n\n\n\n\nHost: Abhimanyu Thakur\,UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-amelie-karlstrom/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231023T090000
DTEND;TZID=Europe/Stockholm:20231027T170000
DTSTAMP:20260403T234751
CREATED:20230811T112638Z
LAST-MODIFIED:20230811T120144Z
UID:10000948-1698051600-1698426000@www.scilifelab.se
SUMMARY:R Foundations for Life Scientists
DESCRIPTION:National course open for PhD students\, postdocs\, researchers and other employees in all Swedish universities\, in need of  programming in R. \n\n\n\n\n\n\n\nImportant dates & Information\n\n\n\nApplication opens: 2023-08-20 \n\n\n\nApplication closes: 2023-09-20 \n\n\n\nConfirmation to accepted students: 2023-09-27 \n\n\n\nCourse Leader and teachers: Nima Rafati (CL)\, Prasoon Argawal (CL)\, Marcin Kierczak (CT)\, Sebastian DiLorenzo (CT) \n\n\n\nIn case you miss information on any of the above dates\, please contact us via edu.r@nbis.se \n\n\n\n\n\n\n\n\n\nApplication\n\n\n\n\n\nCourse website\n\n\n\n\n\n\n\n\n\nCourse fee\n\n\n\nA course fee* of 2000 SEK will be invoiced to accepted participants. The fee includes lunches\, coffee and snacks. \n\n\n\n*Please note that NBIS cannot invoice individuals \n\n\n\n\n\n\n\nCourse content\n\n\n\nThe course covers fundamental concepts of programming and software design focusing on programming in R. We will go through various aspects of R scripting emphasizing the parts useful for life scientists. After introductory lectures on good programming practices\, basic software design theory and a brief overview of R\, we will delve into programming. \n\n\n\nTopics covered will include: \n\n\n\n\nVariables and Operators\n\n\n\nMatrices\, lists\, and dataframes\n\n\n\nData manipulation\n\n\n\nVisualization\n\n\n\nR packages\n\n\n\nBioconductor\n\n\n\n\n\n\n\n\nLearning Outcomes\n\n\n\nUpon completion of this course\, you will be able to: \n\n\n\n\nDescribe different data structures commonly used in R.\n\n\n\nWork with different data types.\n\n\n\nImport and export data from and to R environment. \n\n\n\nManipulate data.\n\n\n\nWork with dataframes and lists.\n\n\n\nVisualize the data.\n\n\n\nExplain about R packages and steps to create them.\n\n\n\nInstall R packages from Bioconductor. \n\n\n\n\n\n\n\n\nEntry requirements\n\n\n\nThe following is a list of skills required for being able to follow the course and complete the exercises: \n\n\n\n\nGood general computer literacy\n\n\n\nBasic knowledge in mathematics and statistics\n\n\n\n\nDue to limited space the course can accommodate a maximum of 20 participants. If we receive more applications\, participants will be selected based on selection criteria\, including (but not limited to) correct entry requirements\, motivation to attend the course\, as well as gender and geographical balance.
URL:https://www.scilifelab.se/event/r-foundations-for-life-scientists/
LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden
CATEGORIES:Course
ORGANIZER;CN="NBIS - National Bioinformatics Infrastructure Sweden":MAILTO:education@nbis.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231019T120000
DTEND;TZID=Europe/Stockholm:20231019T130000
DTSTAMP:20260403T234751
CREATED:20230711T115033Z
LAST-MODIFIED:20231004T092626Z
UID:10000931-1697716800-1697720400@www.scilifelab.se
SUMMARY:Campus Solna Seminar Series: María Bueno Alvez & Diana Mahdessian
DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an  initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nMaría Bueno Alvez\n\n\n\nLinn Fagerberg – alpha 6 \n\n\n\nNext generation blood profiling of pancreatic cancer \n\n\n\n\n\nDiana Mahdessian\n\n\n\nEmma Lundberg – alpha 2 \n\n\n\nIdentification and Validation of Critical Mediators Driving Human Hepatic Stellate Cell (hHSC) activation via human Scar-Associated Macrophages (SAM) Using Spatial Proteomics \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
URL:https://www.scilifelab.se/event/campus-solna-seminar-series-oct-19/
LOCATION:Gamma-6-Pascal\, SciLifeLab\, Tomtebodavägen 23\, Solna\, 17165\, Sweden
CATEGORIES:Community
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_123412496_HDR2-scaled.jpg
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231019T100000
DTEND;TZID=Europe/Stockholm:20231019T110000
DTSTAMP:20260403T234751
CREATED:20230906T070555Z
LAST-MODIFIED:20230907T142252Z
UID:10000966-1697709600-1697713200@www.scilifelab.se
SUMMARY:Using containers to simplify ML training on Berzelius and other supercomputers: beginner-friendly introduction
DESCRIPTION:This webinar is part of the Tools for AI/ML research in life sciences event series arranged by the SciLifeLab Data Centre. \n\n\n\nTitle: Using containers to simplify ML training on Berzelius and other supercomputers: beginner-friendly introduction \n\n\n\nSpeakers: AI engineers from the SciLifeLab Data Centre and application experts from Berzelius (NSC\, LiU). \n\n\n\nWhere and when: October 19\, 2023 at 10:00-11:00 Stockholm time\, online. Registration is open till Oct 18 at 24.00.  \n\n\n\nAbstract: A common approach to train machine learning models is to first create a prototype using a small dataset on a local machine to verify that it works and thereafter use a large scale compute infrastructure such as Berzelius for the full-scale training. One of the challenges with this approach however is incompatible systems in terms of differences in available software packages\, versions\, etc. An effective way to solve this issue is to use a container solution. Using a container environment allows a highly portable workflow and reproducible results between systems as diverse as a laptop\, Berzelius or EuroHPC resources such as LUMI for instance. During this beginner-friendly event\, we will introduce and demonstrate how to work with containers on Berzelius (Apptainer and Enroot) using an example from life sciences\, starting from raw data and finishing with a trained model. During the Q&A session\, the Berzelius life science support team will answer your questions. \n\n\n\nRegister to join the event\n\n\n\nMore about the event series: \n\n\n\nTools for AI/ML research in life sciences is an event series by the SciLifeLab Data Centre aimed at life science researchers who use machine learning methods in their work. The goal of the events in this series is to provide introductions to different tools for ML research but also to foster discussions around our practices and how they can be improved. The events takes place virtually (over Zoom) and are open to researchers in Sweden and beyond. Each event is scheduled for 60 minutes\, consisting of a talk and an extended discussion. Follow the page of the event series to learn about future seminars. \n\n\n\nFor questions about the events please contact the organizing team by emailing  serve@scilifelab.se  \n\n\n\n \n\n\n\nScientific lead: Prof. Ola Spjuth\, SciLifeLab Data Centre and Uppsala University \n\n\n\nContact information: serve@scilifelab.se
URL:https://www.scilifelab.se/event/using-containers-berzelius/
LOCATION:Online event via Zoom
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231017T140000
DTEND;TZID=Europe/Stockholm:20231017T143000
DTSTAMP:20260403T234751
CREATED:20231009T094905Z
LAST-MODIFIED:20231009T094906Z
UID:10000990-1697551200-1697553000@www.scilifelab.se
SUMMARY:CSI Seminar: ‘Burnout and Stress’
DESCRIPTION:We are excited to host a new Coaching in Science Initiative (CSI) Seminar titled: ‘Burnout and Stress’ \nThe number of people with a burnout diagnosis has sky-rocketed during the last decade and it is now considered to be one of our major national diseases. Stress is a natural and important reaction but when the response is kept active for too long it can have negative effects. In this seminar\, we will cover some basic aspects of stress and burnout\, and share personal experiences of going through a burnout process. Together we’ll discuss where we currently experience negative stress and what measures we can take to find and keep a sustainable balance in life. \nDate: 17/10/2023\nTime: 14:00 – 14:30\nZoom link: https://kth-se.zoom.us/j/68847309081\nOn-site location: Gamma 2 lunch room \nWe will begin with a ca 20 min talk\, held in Solna and over zoom. Then proceed with a reflection and discussion held only on-site. We encourage other sites to form watch parties\, by listening in together to the talk and then hold their own discussion afterwards. Hopefully seeding many local chapters of CSI.\nTo help facilitate discussion and reflection\, consider the follow starter questions: \nAwareness: where do we experience high risk for negative stress in our lives?\nAnalysis: how well do I currently handle negative stress?\nAlternative: how can we relate to burnout/stress\, in ourselves and others?\nAction: how will knowledge of burnout/stress change my decisions going forward?
URL:https://www.scilifelab.se/event/csi-seminar-burnout-and-stress/
LOCATION:Hybrid event in Gamma 2 lunchroom and zoom\, Tomtebodavägen 23 B\, Solna\, 17165\, Sweden
CATEGORIES:Community
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/10/CSI_logo_text_mail-2.png
ORGANIZER;CN="Coaching in Science Initiative (CSI)":MAILTO:sami.saarenpaa@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231017T080000
DTEND;TZID=Europe/Stockholm:20231019T170000
DTSTAMP:20260403T234751
CREATED:20230810T125629Z
LAST-MODIFIED:20231013T081404Z
UID:10000946-1697529600-1697734800@www.scilifelab.se
SUMMARY:Introduction to Data Management Practices - Cancelled
DESCRIPTION:This national workshop in Data Management is a co-arranged event between Uppsala University and Chalmers University\, and provides an introduction for PhD students\, postdocs\, researchers\, and other employees within all Swedish universities. The workshop will introduce important aspects of research data management through a series of lectures\, demonstrations\, and hands-on computer exercises. The course is intended for researchers that want to take the first steps towards a more systematic and reproducible approach to analysing and managing research data. CANCELLED – next time (preliminary) in Stockholm\, April 2024 \n\n\n\nTopics covered will include: \n\n\n\n\nOpen Science and FAIR in practice\n\n\n\nOrganising data\, files and folders in research projects\n\n\n\nDescribing data with metadata\n\n\n\nPublishing data to public data repositories\n\n\n\nCleaning tabular data and metadata with OpenRefine\n\n\n\nWriting basic recipes for data analysis and visualisation with R\n\n\n\nVersioning data\, documents and scripts\n\n\n\nWriting Data Management Plans\n\n\n\n\n\n\n\n\nImportant dates\n\n\n\nApplication opens: now \n\n\n\nApplication closes: 2023-09-27 \n\n\n\nInformation to accepted students will be sent:  2023-09-29 \n\n\n\n\n\n\n\nContact\n\n\n\nedu.intro-dm@nbis.se \n\n\n\n\n\n\n\n\n\nApplication\n\n\n\n\n\nCourse website\n\n\n\n\n\n\n\n\n\nFormat\n\n\n\nThis workshop runs in parallel on-site in Uppsala\, and Göteborg. Lectures will be streamed online from our Uppsala site (mainly) to the Gothenburg classrooms\, and vice versa. Teachers and teaching assistants will be present at both locations all week to help with exercises and questions. When registering you will be asked to select a preferred site. \n\n\n\n\n\n\n\nVenues\n\n\n\nUppsala \n\n\n\nTrippelrummet (E10:1307-1309)\, SciLifeLab Navet\, Entrance C11\, Biomedical Centre (BMC) \n\n\n\nHusargatan 3\, 752 37 Uppsala \n\n\n\nGothenburg \n\n\n\nCLS Room Scrum 1\, University library\, 2nd floor  \n\n\n\nHörsalsvägen 2 (entrance)\, 412 96 Gothenburg \n\n\n\n\n\n\n\nCourse fee\n\n\n\nThis on-site training event costs 2000 SEK invoiced to the participant’s organisation. If you accept a position and do not participate (no-show) you will still be invoiced 2000 SEK. Please note that NBIS cannot invoice individuals. \n\n\n\n\n\n\n\nEntry requirements\n\n\n\nNo previous programming experience is required but you are required to bring your own laptop with the required software pre-installed. Installation instructions will be provided before the course starts\, and the course organisers arrange a pre-course event approximately one week prior to first course day. \n\n\n\n\n\n\n\nCredits & Certificate\n\n\n\nPlease note that NBIS training events do not provide any formal university credits. Attendees with full attendance and completion of tasks will be issued a certificate of participation indicating topics covered and duration of the workshop. \n\n\n\nDue to limitations in space and capacity the course can accommodate a maximum of 25 participants per site.  If we receive more applications\, participants will be selected based on several criteria\, including correct entry information\, motivation to attend the course\, as well as gender and geographical balance. \n\n\n\nFor more detailed information about the workshop\, please visit the workshop website.
URL:https://www.scilifelab.se/event/introduction-to-data-management-practices-5/
LOCATION:Uppsala University\, Uppsala and Chalmers University\, Gothenburg
CATEGORIES:Course
ORGANIZER;CN="NBIS - National Bioinformatics Infrastructure Sweden":MAILTO:education@nbis.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231017T080000
DTEND;TZID=Europe/Stockholm:20231019T170000
DTSTAMP:20260403T234751
CREATED:20230411T092159Z
LAST-MODIFIED:20230411T092229Z
UID:10000850-1697529600-1697734800@www.scilifelab.se
SUMMARY:Cryo-EM sample preparation and data collection
DESCRIPTION:The purpose of the course is to prepare and train Cryo-EM facility users in sample preparation methods\, introduce users to the image data acquisition workflow\, expand knowledge about cryo-EM methods among researchers and show that everyone can learn how to use cryo-EM for structure and cell biology. \n\n\n\nThe course is open for facility users or potential facility users\, such as PhD students\, postdocs\, and researchers within the life sciences who are curious and will profit from cryo-EM skills. Swedish and international course participants are welcome. To attend\, the course participants must have experience in basic electron microscopy and be familiar with structure or cell biology. \n\n\n\nThis course is supported by SciLifeLab\, CryoNET and Umeå University and organized by the SciLifeLab Cryo-EM facility\, both UmU and SU nodes together. \n\n\n\nRead more\n\n\n\nApplication deadline\n\n\n\nApplication should be submitted before September 29\, 2023 \n\n\n\nCourse organizers\n\n\n\nMichael Hall \n\n\n\nLocation\n\n\n\nUCEM and Chemical Biological Centre (KBC) BuildingUmeå University\, Linnaeus väg 6 \n\n\n\nTeachers and course instructors\n\n\n\n\n    Linda Sandblad\n\n\n\n    Michael Hall\n\n\n\n    Lars-Anders Carlson\n\n\n\n    Additional teachers t.b.a\n\n\n\n\nSocial program\n\n\n\nA social program depending on the current corona restriction will be communicated to the participants after acceptance. \n\n\n\nCourse content\n\n\n\nThis course will cover practical aspects of cryo-EM sample preparation and data acquisition. \n\n\n\nTopics covered\n\n\n\n\n    Basic theory of vitreous water\, how to handle a cryo sample and consequences\n\n\n\n    Plunge freezing methods\, tools and cryo-transfer\n\n\n\n    Sample and instrument requirements for single particle and tomography methods\n\n\n\n    Image data acquisition\, concept of low dose and the cryo-specific workflow\n\n\n\n    Introduction to automatic data acqui­sition software\, EPU\, Tomography\n\n\n\n    Introduction to cryo-EM image processing methods\n\n\n\n\nThe course consists of lectures\, cryo lab work\, demonstrations and practical exercises for all participants\, hands-on experiences of microscopy operation and discussions. A detailed schedule will be provided to accepted participant. \n\n\n\nCourse literature\n\n\n\nHandouts and material online. \n\n\n\nEntry requirements\n\n\n\nPriority will be given to researchers involved in project where the use of cryo-EM is needed\, which are to be briefly described upon application. \n\n\n\nThe course will be held at an advanced level\, assuming that participants have a master’s degree or equivalent in a technical life science discipline. It aims to be relevant for a broad research community\, also to participants not working in research environments using cryo-EM today. \n\n\n\nA maximum of 15 participants will be admitted. Selection criteria include correct entry requirements\, motivation to attend the course as well as gender balance. \n\n\n\nExamination\n\n\n\nParticipation in all parts of the course\, lectures\, lab\, microscopy demonstrations and evaluation are mandatory. SciLifeLab and Umeå University will provide successful participants with a course certificate and a recommendation for 1 ECTS
URL:https://www.scilifelab.se/event/cryo-em-sample-preparation-and-data-collection-2/
LOCATION:KBC Building Umeå\, Linneaus Väg 6\, Umeå
CATEGORIES:Course
ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231012T120000
DTEND;TZID=Europe/Stockholm:20231012T130000
DTSTAMP:20260403T234751
CREATED:20230711T114929Z
LAST-MODIFIED:20230926T080223Z
UID:10000930-1697112000-1697115600@www.scilifelab.se
SUMMARY:Campus Solna Seminar Series: Annika Bendes & Alexander Petri
DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an  initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nAnnika Bendes\n\n\n\nJochen Schwenk – alpha 2 \n\n\n\nProteome profiling of self-sampled dried blood spots to enhance population-based studies and precision medicine \n\n\n\n\n\nAlexander Petri\n\n\n\nKristoffer Sahlin – gamma 6 \n\n\n\nisONform: reference-free transcriptome reconstruction from Oxford Nanopore data \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
URL:https://www.scilifelab.se/event/campus-solna-seminar-series-oct-12/
LOCATION:Milkyway SciLifeLab Solna\, Tomtebodavägen 23\, Solna
CATEGORIES:Community
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_120135408_HDR-scaled.jpg
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231011T120000
DTEND;TZID=Europe/Stockholm:20231011T130000
DTSTAMP:20260403T234751
CREATED:20231003T063653Z
LAST-MODIFIED:20231003T063813Z
UID:10000979-1697025600-1697029200@www.scilifelab.se
SUMMARY:Metabolomics at speed – can direct analysis fingerprinting metabolomics be used for rapid sample screening?
DESCRIPTION:On-line seminar by Alastair Ross\, Senior researcher/Metabolomics team lead at AgResearch\, New Zealand. \n\n\n\nArranged by Otto Savolainen\, Head of Unit\, Chalmers Mass Spectrometry Infrastructure (CMSI)\, Metabolomics Platform. \n\n\n\nRegistration
URL:https://www.scilifelab.se/event/metabolomics-at-speed-can-direct-analysis-fingerprinting-metabolomics-be-used-for-rapid-sample-screening/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231010T080000
DTEND;TZID=Europe/Stockholm:20231010T170000
DTSTAMP:20260403T234751
CREATED:20230313T112350Z
LAST-MODIFIED:20231009T112407Z
UID:10000834-1696924800-1696957200@www.scilifelab.se
SUMMARY:SciLifeLab Day Linköping
DESCRIPTION:This event is a kick-off for the national SciLifeLab site in Linköping.\n\n\n\nLearn more about the services and capabilities that are offered from SciLifeLab\, both nationally and locally\, and how you can participate in the activities. \n\n\n\nWelcome to the SciLifeLab Day in Linköping. Here\, life-science researchers will have a unique opportunity to meet experts in research infrastructure\, participate in discussions on societal challenges and learn about what SciLifeLab have to offer both locally and nationally. \n\n\n\nExhibition\, poster session\, and mingle\n\n\n\nShow your research in a poster and take the opportunity to discuss how you can implement SciLifeLab’s advanced technologies with the infrastructure experts and visit the exhibitions or posters from the infrastructure units to learn what services they can offer you. \n\n\n\nRead more and find the program\n\n\n\nSciLifeLab etablerar nytt forskningssäte i Linköping\n\n\n\nProgram\n\n\n\nDetailed-program-SciLifeLab-Day-LinkopingDownload\n\n\n\n\n\n\n\nContact\n\n\n\n\n\nlinkoping@scilifelab.se \n\n\n\n\n\nJosefine SandströmLinköping UniversitySite Coordinator SciLifeLab Linköpingjosefine.sandstrom@liu.se\n\n\n\n\n\nSciLifeLab Days on the national sites\n\n\n\n\nGothenburg\, April 17\n\n\n\nUmeå\, September 11\n\n\n\nLund\, September 28\n\n\n\nLinköping\, October 10
URL:https://www.scilifelab.se/event/scilifelab-day-linkoping/
LOCATION:Campus US\, Linköping University\, Lasarettsgatan 20\, Linköping\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/08/1691583487328.jpg
ORGANIZER;CN="SciLifeLab Link%C3%B6ping":MAILTO:linkoping@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231009T090000
DTEND;TZID=Europe/Stockholm:20231013T170000
DTSTAMP:20260403T234751
CREATED:20230614T070145Z
LAST-MODIFIED:20230615T091559Z
UID:10000913-1696842000-1697216400@www.scilifelab.se
SUMMARY:Python programming with applications to bioinformatics
DESCRIPTION:National course open for PhD students\, postdocs\, researchers and other employees in need of fundamental Python skills within all Swedish universities \n\n\n\nResponsible teachers: Nina Norgren\, Dimitris Bampalikis\, Jeanette Tångrot \n\n\n\nContact information: edu.intro-python@nbis.se \n\n\n\nVenues: SciLifeLab Uppsala\, Trippelrummet\, BMC & Umeå University\, Naturvetarhuset\, room NAT.D.370 \n\n\n\n\n\n\n\n\n\nApplication\n\n\n\n\n\nCourse Website\n\n\n\n\n\n\n\n\n\n\n\n\n\nImportant dates\n\n\n\nApplication open: June 15 \n\n\n\nApplication deadline: September 8 \n\n\n\nConfirmation to accepted participants: September 15 \n\n\n\n\n\n\n\nCourse fee\n\n\n\n A course fee* of 3000 SEK will be invoiced to accepted participants. This includes lunches\, coffee and snacks\, and course dinner \n\n\n\n*Please note that NBIS cannot invoice individuals \n\n\n\n\n\n\n\nCourse description\n\n\n\nThis course provides a practical introduction to the writing of Python programs for the complete novice. Participants are led through the core aspects of Python illustrated by a series of example programs. Upon completion of the course\, attentive participants will be able to write simple Python programs from scratch and to customize more complex code to fit their needs. \n\n\n\nFormat \n\n\n\nThis course runs in parallel both on-site in Uppsala and in Umeå. Lectures will be streamed online from our Uppsala site to the Umeå site. Several teaching assistants will be present both in the Umeå and Uppsala classroom all week to help with exercises and questions. When registering you will be asked to which site you apply. \n\n\n\nThe course consists of a mix of presentations\, demonstrations\, and practical exercises (either in the lab with assistants or on your own). Prior to the course\, you can read a companion book “Programming Python”\, or “Learning Python”. Such a book will also prove useful for your programming tasks\, after the course is over. It is however not required\, and material will be presented in class. \n\n\n\n\n\n\n\nCourse content\n\n\n\n\nCore concepts about Python syntax: Data types\, blocks and indentation\, variable scoping\, iteration\, functions\, methods and arguments\n\n\n\nDifferent ways to control program flow using loops and conditional tests\n\n\n\nRegular expressions and pattern matching\n\n\n\nWriting functions and best-practice ways of making them usable\n\n\n\nReading from and writing to files\n\n\n\nCode packaging and Python libraries\n\n\n\nHow to work with biological data using external libraries.\n\n\n\n\n\n\n\n\nLearning outcomes\n\n\n\n\nDescribe and apply basic concepts in Python\, such as:LoopsIf/else statementsFunctions\n\nReading/writing to files\n\n\n\n\n\nBeing able to edit and run Python code\n\n\n\nWrite file-processing Python programs that produce output to the terminal and/or external files\n\n\n\nCreate stand-alone python programs to process biological data\n\n\n\nKnow how to develop your skills in Python after the course (including debugging)\n\n\n\n\n\n\n\n\nEntry requirements\n\n\n\nThe course is suitable for complete beginners and assumes no prior programming experience (beyond the ability to use a text editor). A very basic knowledge of UNIX would be an advantage\, such as navigating through folders and issuing commands at a shell prompt. We will not teach UNIX in detail: Other courses are available at SciLifeLab for it. Make sure your laptop has python installed for the practical exercises. \n\n\n\n\n\n\n\nSelection criteria\n\n\n\nDue to limited space the course can accommodate a maximum of 25 participants in Uppsala and 15 in Umeå. If we receive more applications\, participants will be selected based on several criteria. Selection criteria include correct entry requirements\, motivation to attend the course as well as gender and geographical balance. \n\n\n\nPlease note that NBIS training events do not provide any formal university credits. The training content is estimated to correspond to 1.5 hp credits\, however the estimated credits are just recommendations. If formal credits are crucial\, the student needs to confer with the home department before submitting a course application in order to establish whether the course is valid for formal credits or not.
URL:https://www.scilifelab.se/event/python-programming-with-applications-to-bioinformatics-2/
CATEGORIES:Course
ORGANIZER;CN="NBIS - National Bioinformatics Infrastructure Sweden":MAILTO:education@nbis.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231006T153000
DTEND;TZID=Europe/Stockholm:20231006T163000
DTSTAMP:20260403T234751
CREATED:20231002T160445Z
LAST-MODIFIED:20231002T160654Z
UID:10000981-1696606200-1696609800@www.scilifelab.se
SUMMARY:Seminar "Stereo-Seq to study the brain gene expression across species" - Prof. Wei-Wu
DESCRIPTION:Speaker: Prof. Wei-Wu\n\n\n\nTitle of Talk: Stereo-Seq to study the brain gene expression across species\n\n\n\nThe whole-brain single-cell spatial transcriptome atlas and cross-species comparisonThe brain is the most complex organ of humans with the highest heterogeneity of cell types. The composition and spatial location of different neuron subtypes\, as well as their precise connections\, are the basis for brain functions. Rapid advances in spatial transcriptomic technologies allow spatial mapping of gene expression as well as cellular subtypes at single-cell resolution of brain sections. We applied Stereo-Seq technology developed by BGI\, to construct the whole-brain cell atlas for macaques\, marmoset\, and mice\, with hundreds of coronal slices of spatial transcriptome across the whole brain per animal. Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex and cross-species comparative analysis identified primate-specific cell types enriched in cortical layer 4\, whose marker genes are expressed in a region-dependent manner (Chen et al.\, Cell 2023). Whole-brain cell atlas provides the cellular and molecular basis for understanding the function\, evolution\, development\, aging\, and pathogenesis of the brain. \n\n\n\nHost: Vicent Pelechano & Claudia Kutter
URL:https://www.scilifelab.se/event/seminar-stereo-seq-to-study-the-brain-gene-expression-across-species-prof-wei-wu/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Community
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231006T110000
DTEND;TZID=Europe/Stockholm:20231006T120000
DTSTAMP:20260403T234751
CREATED:20230816T080538Z
LAST-MODIFIED:20231005T084643Z
UID:10000954-1696590000-1696593600@www.scilifelab.se
SUMMARY:From sequences to structures\, from structures to biology - On homo-oligomers and co-translational assembly
DESCRIPTION:Speaker: Emmanuel Levy\, Weizmann \n\n\n\nHost: Arne Elofsson \n\n\n\nIn this talk\, I will provide an overview of our research\, emphasizing two recent pieces of work. The first goes from sequences to structures\, with the development of an atlas of homo-oligomerization spanning proteomes and lineages (https://www.biorxiv.org/content/10.1101/2023.06.09.544317v1). The second goes from structures to biology\, leveraging protein complexes’ structures to crack the code of co-translational assembly.
URL:https://www.scilifelab.se/event/from-sequences-to-structures-from-structures-to-biology-on-homo-oligomers-and-co-translational-assembly/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231005T120000
DTEND;TZID=Europe/Stockholm:20231005T130000
DTSTAMP:20260403T234751
CREATED:20230711T113733Z
LAST-MODIFIED:20230928T130033Z
UID:10000929-1696507200-1696510800@www.scilifelab.se
SUMMARY:Campus Solna Seminar Series: Daniela Almeida & May Britt Rian
DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an  initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nDaniela Almeida\n\n\n\nMarc Friedländer – gamma 5 \n\n\n\nExploring bioactive peptides from Octopus vulgaris proteome after bacterial challenge \n\n\n\n\n\nMay Britt Rian\n\n\n\nJonathan Martin – alpha 1 \n\n\n\nNontarget Analysis of Organic Micropollutants in Swedish Waters \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
URL:https://www.scilifelab.se/event/campus-solna-seminar-series-oct-5/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/12/IMG_4110-scaled.jpg
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231004T090000
DTEND;TZID=Europe/Stockholm:20231005T170000
DTSTAMP:20260403T234751
CREATED:20230220T151823Z
LAST-MODIFIED:20231002T130421Z
UID:10000814-1696410000-1696525200@www.scilifelab.se
SUMMARY:6th CryoNET Symposium in Stockholm
DESCRIPTION:We are very much looking forward to seeing you all in Stockholm on Wednesday. We’ll have a full house of around 200 participants\, some 50 posters and a bunch of exciting speakers. It will be two intense and\, we hope\, enjoyable days! \n\n\n\nCryoNet is a Nordic network in Cryo-electron microscopy that aims to promote collaboration and knowledge sharing across national borders. A main goal is to help establish state-of-the-art cryo-electron microscopy as a strong pillar of Nordic life science research. \n\n\n\nThe core of the network is formed by the Cryo-EM facilities at the University of Copenhagen\, Aarhus University\, Stockholm University and Umeå University. The network also reaches out to Cryo-EM sites in Norway and Finland. \n\n\n\nThe 6th CryoNET Symposium will take place October 4-5 2023 at Stockholm University. Take the opportunity to hear from world leaders in the field and network with students and researchers!  \n\n\n\nParticipation in the symposium is free of charge and includes two days of lectures and a symposium dinner on October 4. We will start at 9:00 on Wednesday 4 October and finish 16:30 on Thursday 5 October. \n\n\n\nWe strongly encourage students and postdocs to submit an abstract about their research project. A number of abstracts will be selected for short talks and there will be a poster session for everyone during the symposium. \n\n\n\nOrganizersGunnar von Heijne\, Marta Carroni\, Arne Elofsson och Xiaodong ZouContact: Gunnar von Heine \n\n\n\n\n\n\n\nProgram & Abstracts\n\n\n\nCryonet_program_abstracts_finalDownload\n\n\n\n \n\n\n\nKeynote Speakers\n\n\n\n\nTamir Gonen\, UCLA\, USA\n\n\n\nEllen Zhong\, Princeton University\, USA\n\n\n\n\nConfirmed Speakers\n\n\n\n\nHenriette Autzen\, Univ. Copenhagen\, Denmark\n\n\n\nTristan Croll\, Altos Labs\, Cambridge\, UK\n\n\n\nFriedrich Förster\, Utrecht Bioinformatic Center\, The Netherlands\n\n\n\nEmil Kristoffersen\, Aarhus University\n\n\n\nKarin Lindkvist\, Lund University\, Sweden\n\n\n\nMisha Kudryashev\, Max Delbrück Center\, Berlin\, Germany\n\n\n\nShintaro Aibara\, AstraZeneca\, UK\n\n\n\nVille Paavilainen\, University of Helsinki\, Finland  \n\n\n\nAnastassis Perrakis\, NKI\, Amsterdam\, The Netherlands\n\n\n\nSuparna Sanyal\, Uppsala University\, Sweden \n\n\n\nLudovic Sauguet\, Institut Pasteur\, Paris\, France\n\n\n\nSuyang Zhang\, LMB-MRC\, Cambridge UK
URL:https://www.scilifelab.se/event/6th-cryonet-symposium-in-stockholm/
LOCATION:Arrhenius Laboratory\, Stockholm University\, Svante Arrhenius väg 16C\, Stockholm
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/02/ClpCP_Carroni.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231003T090000
DTEND;TZID=Europe/Stockholm:20231005T150000
DTSTAMP:20260403T234751
CREATED:20230919T150816Z
LAST-MODIFIED:20230928T094717Z
UID:10000972-1696323600-1696518000@www.scilifelab.se
SUMMARY:Exhibition in Navet at BMC
DESCRIPTION:On October 3-5\, between 09.00-15.00\, you have a new opportunity to visit our exhibition in Navet at BMC. This is a chance to receive information and updates from 30 of the leading life science companies in Sweden. The entrance to Navet will be open between 09:00-10:00 and 13:00-14:00 for external visitors. \n\n\n\n\n\n\n\n\n\nTuesday\, Oct 3 \n\n\n\nAH DiagnosticsWe help laboratories within life science and diagnostics to reach optimal performance by providing innovative quality products and full workflow solutions. \n\n\n\nBio-TechneBio-Techne´s family of brands includes R&D Systems\, Novus Biologicals\, Tocris\, Protein Simple\, ACD and Exosome Dx\, creating a unique portfolio of products & services to empower researchers in Life Science & Clinical Diagnostics. \n\n\n\nBioNordika \n\n\n\nEppendorfEppendorf in the house\, Navet October 3rd! \n\n\n\nMove-it pipettes\, first centrifuge with “green cooling”\, lab consumables made from recycled cooking oils\, new PCR and competitions. \n\n\n\nKem-En-Tec Nordic \n\n\n\nSENSE Multilabel Plate Reader\, Mirus Transfection reagents Efficient\, Low Toxic\, Instant Coomasie Stain 15 min w/o washes\, Antibodies and ELISA kits\, Metabolomic kits\, DNA/RNA extraction kits \n\n\n\nMercodiaFocuses on the development and manufacturing of immunoassays for research and clinical diagnostics\, as well as offering bioanalytical services to pharma- and biotech companies. \n\n\n\nMicromedicMicromedic provides a range of products for microscopy. The portfolio includes brands like Leica Microsystems (microscopes)\, Ibidi (consumable for live cell imaging) and SunJinLab (clearing reagents). \n\n\n\nNordic BioLabsDistributor representing e.g. Promega (enzymes\, reagents)\, Active Motif (epigenetics)\, Lexogen (RNA-seq)\, Invitek (kits)\, Biosearch Technologies (enzymes\, competent cells)\, Cytiva and Capricorn (cell culture) \n\n\n\nPeproTech \n\n\n\nRAMCON ABKombinerar globala produkter och expertis med lokal kunskap för att garantera att våra kunder uppnår bättre resultat på kortare tid. Vi riktar oss till forskare och tillverkare inom industrin\, läkemedel\, kemi och bioteknik. \n\n\n\nThermo Fisher Scientific \n\n\n\n \n\n\n\n\n\nWednesday\, Oct 4 \n\n\n\nAkoya BiosciencesAkoya Biosciences offers comprehensive single-cell imaging solutions that allow researchers to phenotype cells with spatial context and visualize how they organize and interact to influence disease progression and response to therapy. \n\n\n\nBeckman Coulter \n\n\n\nDedicated to developing and providing advanced technologies and equipment for research and discovery to explore new treatment methods. \n\n\n\n \n\n\n\nBecton DickinsonBD Biosciences provides high-quality single cell multiomics (scM) instruments\, reagents\, and bioinformatics tools for reliable\, reproducible scM data \n\n\n\nHyperfine studiosHyperfine Studios\, an animation\, video and illustration production studio. We produce visuals that are scientifically correct and visually appealing. The studio possesses expertise in both science and visual communication. \n\n\n\nMeso Scale \n\n\n\nMettler Toledo \n\n\n\nNordic BioSiteNordic BioSite is a supplier of products for research & diagnostics throughout the Nordics. Let’s talk about your workflow for Genomics and Transcriptomics\, antibodies available in BULK\, and services. \n\n\n\nQiagenQIAGEN delivers Sample to Insight solutions for molecular testing and offers products and services that enable our customers to gain valuable insights from any biological sample – from basic research to clinical healthcare. \n\n\n\nScience ImagingDistributes selected Life Science Products mainly in Scandinavia and Finland. Our goal is to offer comprehensive solutions to the image related problems faced by today’s research communities \n\n\n\nTecan NordicTecan is a Swiss company founded in 1980\, a world-leading provider of automated solutions for laboratories. We develop\, manufacture and distribute our own products worldwide\, with production in Switzerland\, Austria and the USA. \n\n\n\n\n\nThursday\, Oct 5 \n\n\n\nBio-WorksWe supply the biopharmaceutical and biotech industry with WorkBeadsTM chromatography resins and GoBio™ prepacked columns for the purification of a wide range of biomolecules\, e.g. proteins and peptides. \n\n\n\nGenScriptGenscript biotech is global CRO provider of genes\, protein\, peptides and antibodies as a products and services for research and clinical use \n\n\n\nHamilton Nordic \n\n\n\nIntegrated DNA Technologies \n\n\n\nLabLife NordicExciting news for cell- and molecular biosciences\, Label-free cell characterization and sorting\, NGS & single cell sample prep and target enrichment panels\,Oligo synthesis\, Cell assay sample prep\, Cleanup and extraction\, Western blot \n\n\n\nNavinciNavinci is a Swedish biotech company that specializes in developing innovative solutions for the study of protein interactions based on our proprietary proximity ligation technology – Bringing Precision to Spatial Proteomics. \n\n\n\nPacific BiosciencesPacBio is a life science technology company that is providing advanced sequencing solutions that enable scientists to improve their understanding of the genome and ultimately\, resolve genetically complex problems. \n\n\n\nShimadzuShimadzu Sweden provides a broad range of analytical instruments indispensable for research\, development\, and quality control in a variety of fields. \n\n\n\nTakara Bio \n\n\n\nCommitted to helping scientists break new ground with innovative technologies. Our extensive portfolio offers solutions to support advancements across many areas of research\, diagnostics\, & clinical applications \n\n\n\nTechtum LabA distributor of cutting-edge laboratory equipment and solutions for molecular biology research will exhibit at BMC Navet October 5. Live demos of a selection of our instruments!
URL:https://www.scilifelab.se/event/exhibition-in-navet-at-bmc-2/
LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/03/Navet.jpg
ORGANIZER;CN="SciLifeLab Navet":MAILTO:lokalbokning@scilifelab.uu.se
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230929T100000
DTEND;TZID=Europe/Stockholm:20230929T110000
DTSTAMP:20260403T234751
CREATED:20230816T080214Z
LAST-MODIFIED:20230922T144940Z
UID:10000952-1695981600-1695985200@www.scilifelab.se
SUMMARY:Computational Enzymology - Identifying Catalytic Modules and predicting Mechanisms
DESCRIPTION:Speaker: Janet Thornton\, EBI \n\n\n\nComputational Enzymology: Towards using knowledge of structure and function to predict enzyme transformations and mechanisms. \n\n\n\nJM Thornton\, AJM Ribeiro\, Ioannis Riziotis\, JD Tyzack\, Neera Borkakoti\, Roman Laskowski. European Bioinformatics Institute (EMBL-EBI)\, Wellcome Genome Campus\, Cambridge CB10 1SD\, UK \n\n\n\nEnzymes catalyse most of the chemical reactions which are essential for life. They are powerful catalysts that have evolved over millions of years to perform the functions in an organism that are necessary for survival. Using structural data and computational biology we seek to understand and predict how enzymes work and how they evolve to perform new enzyme functions. In this talk I will present our ongoing work to ‘perform catalysis’ in the computer. Using methods developed in cheminformatics\, combined with information derived from 3D enzyme structures\, we are developing tools to predict transformations and mechanisms.  \n\n\n\nHost: Arne Elofsson \n\n\n\nDame Janet M Thornton has contributed significantly to structural bioinformatics by increasing our fundamental understanding of the structure and function of proteins and how they contribute to disease and ageing. She has uniquely combined the analysis of structural features with the development of prediction methods. Together with Christine Orengo\, the popular database CATH was developed. Her studies of sidechain conformation and stereochemistry were developed with Roman Laskowski into a tool\,  PROCHECK\, widely used for evaluating the quality of experimentally defined protein structures. With Orengo and David Jones she developed methods for protein structure prediction. She was the director of the European Bioinformatics Institute from 2001 to 2015 and initiated the European infrastructure ELIXIR.
URL:https://www.scilifelab.se/event/computational-enzymology-identifying-catalytic-modules-and-predicting-mechanisms/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230928T120000
DTEND;TZID=Europe/Stockholm:20230928T130000
DTSTAMP:20260403T234751
CREATED:20230711T113608Z
LAST-MODIFIED:20230917T073027Z
UID:10000928-1695902400-1695906000@www.scilifelab.se
SUMMARY:Campus Solna Seminar Series: Lina Stepanauskaite & Guillem Marin Aguilera
DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an  initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nLina Stepanauskaite\n\n\n\nCecilia Williams – alpha 2 \n\n\n\nInflammation effect on microbiota composition in mice \n\n\n\n\n\nGuillem Marin Aguilera\n\n\n\nIlaria Testa – gamma 3 \n\n\n\nNovel methodology to measure rotational diffusivity with fluorescence photo-switching \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
URL:https://www.scilifelab.se/event/campus-solna-seminar-series-sept-28/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_124630107_HDR-scaled.jpg
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230928T080000
DTEND;TZID=Europe/Stockholm:20230928T170000
DTSTAMP:20260403T234751
CREATED:20230313T112118Z
LAST-MODIFIED:20230926T140525Z
UID:10000833-1695888000-1695920400@www.scilifelab.se
SUMMARY:SciLifeLab Day Lund
DESCRIPTION:SciLifeLab has launched four new sites across Sweden in 2022. The sites\, located in Gothenburg\, Linköping\, Lund\, and Umeå\, will be crucial in promoting scientific research and research infrastructure nationally\, while also strengthening the collaboration between all Swedish universities. \n\n\n\nThe expansion of SciLifeLab’s network will provide researchers across Sweden with state-of-the-art research infrastructure and technology\, enabling them to perform cutting-edge research in areas such as genomics\, proteomics\, and bioinformatics. This will not only help to advance scientific knowledge but also contribute to the development of innovative solutions to pressing societal challenges. \n\n\n\nThe launch of the national sites\, in addition to existing ones in Stockholm and Uppsala\, will also contribute to the development of a stronger research environment\, crucial for attracting talented researchers and investment to the country\, further cementing Sweden’s position as a leader in scientific research. \n\n\n\nThroughout this year\, each site arrange a whole day program to highlight the national and local perspectives of SciLifeLab.  \n\n\n\nConference proceedings\n\n\n\nSciLifeLab-Day-Lund-Booklet-finalDownload\n\n\n\nProgram\n\n\n\nSciLifeLab-Day-in-Lund-ProgrammeDownload\n\n\n\n\n\n\n\nContact\n\n\n\n\n\n lund@scilifelab.se \n\n\n\n\n\nEsther González-PadillaLund UniversitySite Coordinator SciLifeLab Lundesther.gonzalez-padilla@scilifelab.se (+46) 76-517 38 35\n\n\n\n\n\nVenue\n\n\n\n\n\n\n\nSciLifeLab Days on the national sites\n\n\n\n\nGothenburg\, April 17\n\n\n\nUmeå\, September 11\n\n\n\nLund\, September 28\n\n\n\nLinköping\, October 10
URL:https://www.scilifelab.se/event/scilifelab-day-lund/
LOCATION:Forum Medicum\, Fernströmsalen\, Sölvegatan 19\, Lund\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/05/SciLifeLab-Day-Lund-Registration-with-QR.png
ORGANIZER;CN="SciLifeLab Lund":MAILTO:lund@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230927T130000
DTEND;TZID=Europe/Stockholm:20230927T160000
DTSTAMP:20260403T234751
CREATED:20230810T123753Z
LAST-MODIFIED:20230821T145434Z
UID:10000945-1695819600-1695830400@www.scilifelab.se
SUMMARY:Computational and chemical approaches to drug repurposing
DESCRIPTION:Welcome to Xuexin Li’s doctoral thesis defense 1 September at 09.00 in Samuelssonsalen\, Tomtebodavägen 6\, Solna \n\n\n\nTitle\n\n\n\n“Computational and chemical approaches to drug repurposing” \n\n\n\nAuthor\n\n\n\nXuexin Li\, Department of Medical Biochemistry and Biophysics\, Karolinska Institutet \n\n\n\nPrincipal Supervisor\n\n\n\nProf. Oscar Fernandez-Capetillo\, Department of Medical Biochemistry and Biophysics\, Karolinska Institutet \n\n\n\nCo-supervisor\n\n\n\nDr. Daniela Hühn\, Department of Medical Biochemistry and Biophysics\, Karolinska Institutet \n\n\n\nOpponent\n\n\n\nDr. Brinton Seashore-Ludlow\, Department of Oncology-Pathology\, Karolinska Institutet \n\n\n\nExamination Board\n\n\n\nProf. Per Svenningsson\, Department of Clinical Neuroscience\, Karolinska Institutet \n\n\n\nProf. Ernest Arenas\, Department of Medical Biochemistry and Biophysics\, Karolinska Institutet \n\n\n\nProf. Patrick Aloy\, Structural Systems Biology lab\, Institut de Recerca Biomèdica de Barcelona
URL:https://www.scilifelab.se/event/computational-and-chemical-approaches-to-drug-repurposing/
LOCATION:Samuelssonsalen\, Tomtebodavägen 6\, Solna\, Sweden
CATEGORIES:Community
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230927T100000
DTEND;TZID=Europe/Stockholm:20230927T110000
DTSTAMP:20260403T234751
CREATED:20230810T123528Z
LAST-MODIFIED:20230829T092737Z
UID:10000944-1695808800-1695812400@www.scilifelab.se
SUMMARY:Blending Chemistry and Biology to Enable Systems Pharmacology
DESCRIPTION:Patrick Aloy\, Prof.\, Institute for Research in Biomedicine (IRB Barcelona) \n\n\n\n \n\n\n\nOrganizers \n\n\n\nCBCS-KI and PhenoTarget Research Community Program \n\n\n\nJoin the seminar on Zoomhttps://ki-se.zoom.us/j/64473979770 \n\n\n\nAbstract \n\n\n\nBig Data analytical techniques and AI have the potential to transform drug discovery\, as they are reshaping other areas of science and technology\, but we need to blend biology and chemistry in a format that is amenable for modern machine learning. In this talk\, I will present the Chemical Checker (CC)\, a resource that provides processed\, harmonized and integrated bioactivity data on small molecules. The CC divides data into five levels of increasing complexity\, ranging from the chemical properties of compounds to their clinical outcomes. In between\, it considers targets\, off-targets\, perturbed biological networks and several cell-based assays such as gene expression\, growth inhibition and morphological profiles. I will also present the Bioteque\, a resource of unprecedented size and scope that contains pre-calculated biomedical embeddings around 11 biological entities (e.g. genes\, cells\, tissues\, disease\, etc)\, derived from a gigantic knowledge graph\, so that each entity can be described considering different contexts (e.g. interactions\, expression\, etc). With small molecule and biological bioactivity descriptors in hand\, we now face a new scenario for chemical and biological entities where they both are translated into a common numerical format. In this computational framework\, complex connections between entities can be unveiled by means of simple arithmetic operations. Indeed\, we demonstrate and experimentally validate that these descriptors can be used to reverse and mimic biological signatures of disease models and genetic perturbations in vitro and in vivo\, options that are otherwise impossible using chemical information alone.ReferencesDuran-Frigola et al. Extending the small molecule similarity principle to all levels of biology with the Chemical Checker. 2020. Nat Biotechnol. 38: 1087-1096. \n\n\n\nBertoni et al. Bioactivity descriptors for uncharacterized chemical compounds. 2021. Nat Commun. 12: 3932. \n\n\n\nPauls et al. Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in AppNL-G-F\, AppNL-F\, and 3xTg-AD mouse models. 2021. Genome Med. 13:168. \n\n\n\nFernández-Torras et al. Connecting chemistry and biology through molecular descriptors. 2022. Curr Opin Chem Biol\, 66: 102090. \n\n\n\nFernández-Torras et al. Integrating and formatting biomedical data in the Bioteque\, a comprehensive repository of pre-calculated knowledge graph embeddings. 2022. Nat Commun. 13: 5304.
URL:https://www.scilifelab.se/event/blending-chemistry-and-biology-to-enable-systems-pharmacology/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230926T140000
DTEND;TZID=Europe/Stockholm:20230926T153000
DTSTAMP:20260403T234751
CREATED:20230904T110830Z
LAST-MODIFIED:20230922T152355Z
UID:10000964-1695736800-1695742200@www.scilifelab.se
SUMMARY:FAIRPoints 'Ask Me Anything' webinar on Equitable and transparent access to information
DESCRIPTION:Welcome to join SciLifeLab Data Centre for this virtual FAIRPoints ‘Ask Me Anything’ event. The theme of this session is “FAIRPoints ‘Ask Me Anything’ on Equitable and transparent access to information“. A discussion about the role of infrastructure for open and equitable access of information\, how this reflects in design decisions and how open and FAIR relate to or mean to the rest of the world.  \n\n\n\nSpeakers: Sharif Islam; DiSSCo (Distributed System of Scientific Collections)\, and Karl Meyer; GÉANT. The event is moderated by Emma Wilson. \n\n\n\nWhen: Sept 26th 14.00-15.30 CEST virtual event.  \n\n\n\nThis event is hosted by SciLifeLab Data Centre in collaboration with FAIRPoints\, RDA\, EOSC and FDO.  \n\n\n\n\nRegister\n\n\n\n\n \n\n\n\nFor more information or inquiries please contact: Sara El-Gebali\, SciLifeLab Data Centre\, Project leader\, Metadata and curation\, sara.elgebali@scilifelab.uu.se  or fairpoints@protonmail.com \n\n\n\nLearn more about FAIRPoints\, an event series highlighting pragmatic measures developed by the community towards the implementation of the FAIR (Findable\, Accessible\, Interoperable\, Reusable) data principles here.
URL:https://www.scilifelab.se/event/fairpoints-ask-me-anything-webinar/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="SciLifeLab Data Centre":MAILTO:datacentre@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230926T080000
DTEND;TZID=Europe/Stockholm:20230928T170000
DTSTAMP:20260403T234751
CREATED:20230411T092804Z
LAST-MODIFIED:20230912T113701Z
UID:10000851-1695715200-1695920400@www.scilifelab.se
SUMMARY:Basic Course in Scanning and Transmission Electron Microscopy for Life Sciences
DESCRIPTION:This course covers lectures and practical demonstrations in SEM and TEM techniques\, specifically for life science applications. The contents include principles of electron microscopy\, specimen preparation\, cryo-electron microscopy and correlative light-electron microscopy. For electron microscopy in physical science applications\, there will be a similar-content basic course in early 2024. \n\n\n\nRead more\n\n\n\nApplication deadline: The registration closes on September 15 2023. \n\n\n\nLocation: Lectures at KBC Building and laboratory demonstrations at UCEM. \n\n\n\nParticipants: 18 persons \n\n\n\nInstructors: UCEM staff \n\n\n\nDuration: 3 days \n\n\n\nBreaks/Refreshments: Coffee\, cookies and fruit. \n\n\n\nCosts: No course fee\, but full attendance is required! \n\n\n\nExamination/Credits\n\n\n\nOral and practical examinations are conducted during laboratory demonstrations. A course certificate will be given after participants attend all lectures and laboratory demonstrations for this 3-day course. UCEM recommends PhD program examiners to give 1 ECTS after successful participation.
URL:https://www.scilifelab.se/event/basic-course-in-scanning-and-transmission-electron-microscopy-for-life-sciences/
LOCATION:KBC Building Umeå\, Linneaus Väg 6\, Umeå
CATEGORIES:Course
ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230925T151500
DTEND;TZID=Europe/Stockholm:20230925T161500
DTSTAMP:20260403T234751
CREATED:20230831T123645Z
LAST-MODIFIED:20230901T121318Z
UID:10000958-1695654900-1695658500@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Targeting Non-Coding RNAs Using Synthetic Small Molecules: Original Targets for Innovative Therapies
DESCRIPTION:Dr Maria Duca \n\n\n\nCNRS Research Director\, Université Côte d’Azur\, FranceWebsite: icn.univ-cotedazur.fr/tna \n\n\n\nHost: Duc Duy Vo duc.duy.vo@kemi.uu.se\, UU \n\n\n\nBio\n\n\n\nDr. Maria Duca is head of Targeting of Nucleic Acids research group in the Institute of Chemistry of Nice (Université Côte d’Azur – CNRS). After undergraduate studies in Pharmacy and Medicinal Chemistry (Faculty of Pharmacy\, University of Bologna\, Italy)\, she obtained her PhD in Molecular Biochemistry under the supervision of Dr. Paola B. Arimondo (National Natural History Museum\, Paris\, France) working on topoisomerase II inhibitors. A 2-year post-doctoral training in Sydney Hecht’s lab (Department of Chemistry\, University of Virginia\, USA) allowed her to pursue the study of nucleic acids working on targeted protein mutagenesis. After CNRS recruitment as a Research Scientist in 2008 and promotion to Director of Research in 2022\, her research activities focus on the targeting of non-coding RNAs using synthetic small molecules toward innovative therapeutic approaches for anticancer\, antiviral and antimicrobial applications. She has been awarded the Michel Delalande award from the Académie de Pharmacie as well as national and international grants including H2020 grants. She is Associate Editor for RSC Medicinal Chemistry journal\, chair of the Chemical Biology Initiative of EFMC as well as vice-president of the French medicinal chemistry society. \n\n\n\n \n\n\n\nTargeting Non-Coding RNAs Using Synthetic Small Molecules: Original Targets for Innovative Therapies\n\n\n\nRNA is one of the most intriguing and promising biological targets for the discovery of innovative drugs in a large number of pathologies and various biologically relevant RNAs that could serve as drug targets have already been identified.1 Among the most important ones\, it is worth to mention prokaryotic ribosomal RNA which is the target of a number of currently employed antibiotics\, viral RNAs such as TAR\, RRE and DIS RNA of HIV-1 or oncogenic microRNAs that are tightly involved in the development and progression of various cancers.2 However\, difficulties in the rational design of strong and specific small-molecule ligands renders this kind of molecules relatively rare. \n\n\n\nIn this presentation\, the structure-based design of new RNA ligands targeting oncogenic RNAs will be illustrated together with the identification of new compounds bearing a promising biological activity.3 Also\, it will be shown how the active binders can be employed as chemical tools for a better understanding of the formed interactions toward the design of optimized compounds.4 Finally\, the use of RNA binders for the validation of new antibacterial targets against resistant bacterial strains will be described to highlight the potential of the small-molecule approach in RNA targeting. \n\n\n\nReferences \n\n\n\n[1] J. Childs-Disney\, X. Yang\, Q. Gibaut\, Y. Tong\, R. Batey\, M. Disney\, Nat. Rev. Drug. Discov. 2022\, 21\, 736. \n\n\n\n[2] J. Falese\, A. Donlic\, A. Hargrove\, Chem. Soc. Rev. 2021 50\, 2224. \n\n\n\n[3] D. D. Vo\, C. Becquart\, T. Tran\, A. Di Giorgio\, F. Darfeuille\, C. Staedel\, M. Duca\, Org. Biomol. Chem. 2018 16\, 6262; C. Staedel\, T. Tran\, J. Giraud\, F. Darfeuille\, A. Di Giorgio\, N. Tourasse\, F. Salin\, P. Uriac\, M. Duca\, Sci. Rep. 2018 8\, 1667. \n\n\n\n[4] Maucort\, C.\, Vo\, D.D.\, Aouad\, S.\, Charrat\, C.\, Azoulay\, S.\, Di Giorgio\, A.\, Duca\, M. ACS Med. Chem. Lett. 2021 12\, 899; Tran\, T.P.A.\, Poulet\, S.\, Pernak\, M.\, Rayar\, A.\, Azoulay\, S.\, Di Giorgio A.\, Duca\, M. RSC Med. Chem. 2022 13\, 311; Scheheoleva I.\, Fernandez-Remacha\, D.\, Estrada-Tejedor\, R.\, Duca\, M.\, Michelet\, V. Chem. Eur. J. 2023 doi.org/10.1002/chem.202300825
URL:https://www.scilifelab.se/event/the-svedberg-seminar-maria-duca/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230925T100000
DTEND;TZID=Europe/Stockholm:20230925T110000
DTSTAMP:20260403T234751
CREATED:20230816T080428Z
LAST-MODIFIED:20230816T080740Z
UID:10000953-1695636000-1695639600@www.scilifelab.se
SUMMARY:Dissecting peripheral protein-membrane interfaces
DESCRIPTION:Speaker: Nathalie Reuter\, Department of Chemistry and Computational Biology Unit\, University of Bergen \n\n\n\nHost: Arne Elofsson \n\n\n\nAbstract \n\n\n\nPeripheral membrane proteins (PMPs) are soluble proteins that bind transiently to the surface of cell membranes. Peripheral membrane proteins include a wide variety of proteins including membrane-targeting domains such as C1\, C2\, FYVE\, PH\, PX\, ENTH and GLA\, enzymes involved in lipid metabolism such as phospholipases\, membrane remodeling. machines such as BAR domains or ESCRTIII\, and lipid-transfer proteins to name a few. Having the ability to exist in both a soluble and a membrane-bound form their membrane-binding region is constrained to retain a fine balance of polar and hydrophobic character\, which makes it difficult to distinguish it from the rest of their surface. As a result peripheral membrane-binding sites are notoriously difficult to predict. \n\n\n\nWe collected and curated a dataset containing 2500 structures and compared their membrane-binding sites to the rest of their solvent-accessible surfaces\, in order to reveal features of PMPs’membrane-binding sites. We find that\, among positively charged amino acids\, lysines are significantly more present than arginines. Protruding hydrophobes are a landmark of the interfacial binding sites of ca. 2/3 of peripheral membrane binding proteins\, indicating that a majority of PMPs takes advantage of the hydrophobic effect while a non-negligeable minority (1/3) most likely relies on electrostatics interactions or other mechanisms. The IBS of peripheral membrane proteins contain significantly more glycines than the rest of their surface. Furthermore the analysis of 9 superfamilies revealed amino acid distribution patterns in agreement with their known functions and membrane-binding mechanisms. \n\n\n\nThese findings and the collected dataset will be useful for the development of prediction models for membrane-binding sites of PMPs.
URL:https://www.scilifelab.se/event/dissecting-peripheral-protein-membrane-interfaces/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230921T120000
DTEND;TZID=Europe/Stockholm:20230921T130000
DTSTAMP:20260403T234751
CREATED:20230829T082158Z
LAST-MODIFIED:20230829T082159Z
UID:10000941-1695297600-1695301200@www.scilifelab.se
SUMMARY:Metabolomics for the masses
DESCRIPTION:Metabolites reflect the interaction between the gene cascade and surrounding exposures and are therefore essential components in all living organisms. Metabolites can be used to identify biomarkers of both health conditions and environmental exposures. The SciLifeLab Metabolomics platform offers a range of services\, which will be presented during this talk\, for researchers interested in metabolomics. \n\n\n\nThe presenter\, Otto Savolainen\, is head of the Swedish Metabolomics Centre (SMC)\, which offers small molecule\, lipid and metabolomics analysis in biological tissues and fluids using mass spectrometry methods\, in Gothenburg.  The SciLifeLab site in Gothenburg includes units at both the University of Gothenburg and Chalmers University of Technology and has a strong connection to Sahlgrenska University Hospital. The SMC unit in Gothenburg is part of the Chalmers Mass Spectrometry Infrastructure (CMSI). \n\n\n\nA light lunch will be offered for those attending onsite. \n\n\n\nregistration\n\n\n\nDeadline for registration is 19/9.
URL:https://www.scilifelab.se/event/metabolomics-for-the-masses/
LOCATION:Birgit Thilander Lecture Hall\, Medicinaregatan 3\, Göteborg
CATEGORIES:Event
ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se
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