SciLifeLab

The Nagoya Protocol in Action: Practical Steps for Compliance and Benefit-Sharing
2025-03-11 10:00 - 11:00 (Europe/Stockholm) | Online event via Zoom
This presentation will focus on how to handle the Nagoya Protocol in practice. Whether you’re new to it or already have some experience, you’ll get clear guidance on how to stay compliant, draft agreements, and navigate access and benefit-sharing rules. We’ll go through practical steps, common challenges, and what to aim for when working with genetic resources. The goal is to make the process more manageable and help you confidently meet legal requirements while building fair collaborations.

Conducting research using genetic resources? Collecting biological material?The Nagoya Protocol establishes a framework that helps researchers access genetic resources for research & development in return for a fair share of any benefits from their use. Curious about the rules for the use of genetic resources? In this seminar, Sebastian Bromander from SLU – Sveriges Lantbruksuniversitet will explain how to handle the Nagoya Protocol in practice!

Presenter: Sebastian BromanderSwedish University of Agricultural Sciences (SLU)

Link to the recording on YouTube.

Link to the presentation slides.

More info
This event is part of the SciLifeLab Data Management seminar series, an event series by the SciLifeLab Data Centre and NBIS joint Data Management team.

The goal of the events in this seminar series is to provide interesting interactive seminars around topics related to Research Data Management and Open Science in general, and to foster discussions around best practices.

The events are open to everyone working at or affiliated with a Swedish research institute or university. We welcome all researchers, educational professionals, staff, RDM professionals, and others with an interest in life sciences, from all university levels. The events are informal and inclusive, so feel welcome to join and participate in our interesting discussions!

The events will be recorded and published openly after the seminars on the SciLifeLab YouTube channel.

Link to the recording on YouTube.

Link to the presentation slides will follow soon.More information about SciLifeLab Data Centre and NBIS joint Data Management seminar series: https://www.scilifelab.se/data/scilifelab-data-management-seminar-series/

For more information or inquiries, please contact: data-management@scilifelab.se

Exhibition in Navet at BMC, Uppsala University
2025-03-11 09:00 - 2025-03-13 15:00 | Navet, SciLifeLab Uppsala, SciLifeLab Uppsala, BMC C11, Husargatan 3, Uppsala, 75237, Sweden
On March 11-13, between 09.00-15.00, you have a new opportunity to visit our exhibition in Navet at BMC. This is a chance to receive information and updates from 30 of the leading life science companies in Sweden. The entrance to Navet will be open between 09:00-15:00 for external visitors.

[The Svedberg seminar] - Human beta cell protection by Nature
2025-03-10 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Bart RoepProfessorLeiden University Medical Center, Netherlands

Bio

Bart Roep is Professor of Medicine & Professor of Diabetology, Immunopathology and Intervention at the Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands, where he heads the Section Immuno-modulation & Regenerative Medicine. He studied Medicine and Life Sciences at the University of Amsterdam and obtained his PhD in Medicine at Leiden University. He pioneered studies on the role of T-cells in the pathogenesis of T1D and discovered some of their targets in β-cells, provided seminal proof of their role in human β-cell destruction and defined immune correlates of disease progression and therapeutic intervention. He contributed to a suite of clinical intervention trials in T1D, including pioneering strategies on tissue-specific tolerance induction, regenerative medicine, gene and stem cell therapy, faecal microbiome transplantation and β-cell replacement therapies (pancreatic donor islets and embryonic stem cell derived β-cell progenitors). A profound twist in prevalent belief of the immunopathogenesis involved his discovery of the role of β-cells in their own demise. His current focus is on regenerative medicine in T1D from an immunological perspective.

Human beta cell protection by Nature

Type 1 diabetes results from an autoimmune mediated destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans in people with genetic predisposition to develop this disease. Insulin gene (INS) variation and beta-cell stress associate with risk for development of type 1 diabetes (T1D) and autoimmunity against insulin. We discovered the relationship between ER stress and insulin mRNA from INS risk variants in human β-cells, and how this variation relates to β-cells function, stress and immunogenicity. This novel explanation for genetic protection from T1D inferred by INS polymorphism, puts β-cells in the center of T1D pathogenesis. Beta cells carrying this particular protective INSP variant can alleviate ER stress by insulin mRNA decay, resulting in reduced immunogenicity and improved islet function. We propose that INSP is a causal variant contributing to genetic protection from T1D. The clinical and therapeutic implications of this discovery will be discussed.

Host: Olov Andersson olov.andersson@mcb.uu.se, UU

Workshop for Cryo-electron Tomography
2025-03-10 08:00 - 2025-03-14 17:00 | KBC Building Umeå, Linneaus Väg 6, Umeå
Location: UCEM facility (EM-building) and Chemical Biological Centre (KBC) building, Umeå University, Linnaeus väg 6, Umeå

Deadline for registration: 13 January 2025

Cryo-electron tomography (cryo-ET) is a powerful structural technique. Its power comes from its versatility to study biological systems in vitro or in situ, i.e. within cells or tissue. It has the ability to reach uncharted regions in biological systems at high resolution. Advancements in microscopes, cameras, and computation make it now possible to determine sub-10 Å 3-dimensional structures of molecules directly within cells.

This four-and-a-half-day workshop will cover cryo-ET workflows from sample preparation on EM grids to data processing and analysis. The workshop will be a mixture of lectures and practical sessions. Participants will get hands-on experience in sample preparation on EM grids (micropatterning), sample freezing (plunge freezing and high-pressure freezing), cryo-correlative light and electron microscopy (cryo-CLEM), cryo-focused ion beam milling (cryo-FIB), cryo-TEM tiltseries data collection, and data processing and analysis (MotionCor2, IMOD, Dynamo).

It is compulsory that applicants have previous cryo-EM experience either with single-particle or already with cryo-tomography.

This workshop is supported by SciLifeLab, CryoNET and Umeå University and organized by the Umeå Centre for Electron Microscopy (UCEM).

Contact email: erin.schexnaydre@umu.se

Ultrasensitive variant detection with ddPCR and sRCA
2025-03-07 14:00 - 15:00 | Online event via Zoom
Clinical Genomics Webinar Series

Clinical Genomics Uppsala is hosting this webinar as part of the webinar series by the Clinical Genomics Platform

join zoom webinar

The webinar will focus on Rare tumor-specific mutations are valuable markers for tracking disease progression and therapy responses. As disease relapse remains a major challenge in Myelodysplastic Syndrome, the need for ultrasensitive assay techniques for detecting these very low frequency mutations are needed to detect relapse at the earliest time possible.

In Clinical Genomics Uppsala we explore superRCA assays—an advanced, highly sensitive, and cost-effective amplification technology, in a retrospective study in patients with MDS, monitoring the pre-identified patients mutations after hematopoietic stem-cell transplantation. This method has shown a very high sensitivity, enables detection of DNA variants at very low frequencies using standard flow cytometry, and the results and performance was compared with the results of ddPCR, commonly used method in the clinic.

Everyone is welcome so feel free to spread the details with anyone who may be interested. Hope to see you there!

Host: Malin Melin, co-PD

Invited speakers: Lei Chen, Rarity Bioscience and Sara Löfgren, Clinical Genomics Uppsala

Campus Solna Seminar Series: Sarah Narrowe Danielsson & Taobo Hu
2025-03-06 12:00 - 13:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Sarah Narrowe Danielsson

Arne Elofsson – alpha 6

Predicting protein-protein interactions using machine learning

Taobo Hu

Mats Nilsson – gamma 4

Single-Cell Spatial Transcriptomics Reveals Molecular Correlation with Morphological Invasiveness in Noguchi Type C Lung Adenocarcinoma

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

Automation of research processes with LLMs and AI
2025-03-06 10:00 - 16:00 | Eva & Georg Klein lecture hall, Biomedicum, Solnavägen 9, 171 65 Solna, Solna, 171 65, Sweden
SciLifeLab is thrilled to invite you to the symposium ‘Automation of research processes with LLMs and AI’, to be held on March 6 at Eva & Georg Klein lecture hall, Biomedicum, Karolinska Institutet Campus Solna.

The purpose of the symposium is practical knowledge sharing, inspiration, and reflection on the future of scientific processes in life sciences and health research. Academic, healthcare, and industry researchers working within the broad life sciences are welcome to attend.

More and more AI-based tools are currently being integrated in scientific research processes, from simple academic text editing tools to automated labs empowered by large language models (LLMs) running experiments and making scientific conclusions. For researchers in life sciences and health, developments in the AI technologies are important because of the high potential, large monetary investments, but also expectations about future breakthroughs.This one-day event offers an opportunity for the researchers to hear about specific examples of incorporating Large Language Models (LLMs) and other recent developments in foundational AI models in research workflows as well as to discuss the future of scientific research processes with this new technology present.

We will start the morning with inspirational talks about new advances in research workflow automation. During lunch, there will be a possibility to network and discuss different perspectives with other attendees. After lunch we plan to have interactive sessions where the audience will have an opportunity to share and discuss visions and expectations, including spontaneous flash/pop-up talks by the attendees.

The talks will be livestreamed through Zoom. The rest of the event is on-site in Biomedicum only.

Registration

Registration

Participation is free of charge on the first-come first-served basis. Refreshments and lunch will be served for the on-site participants. Unfortunately, we cannot accommodate allergies or dietary preferences for those who register after March 1. If you register to listen to livestreamed talks on Zoom, you will receive a link on the day of the event. The talks will not be recorded and saved, only streamed live on the day.

Register to attend

Waiting List

To avoid empty seats, registration will remain open until the event begins. If we reach full capacity, a waiting list will be activated. Sign up for the waiting list, and you will automatically receive an email when a spot becomes available. You must accept to secure the spot. If you decline, the offer will go to the next person on the waiting list.

Cancellation

To minimize empty seats and especially food waste, you must cancel your registration if you are unable to attend the event. If a waiting list is activated, your spot will go to someone else. Otherwise, your cancellation will result in us covering the cost of your refreshments and lunch.

If you have questions, please contact datacentre@scilifelab.se

Speakers

Olli Kallioniemi (KI/FIMM) – AI-Empowered Life Science: How Can You Benefit Today and in the Future?
Nobel prizes, huge tech investments, generative AI and AI agents, multidisciplinary expertise, expectations on emerging superhuman intelligence, and 1,000+ AI-powered approved medical devices all highlight AI’s transformative potential for life scientists. Yet, many researchers remain unaware or skeptical, often due to limited exposure. This talk will cover AI’s current and future impact in life sciences, highlighting how it can empower every scientist, boost research productivity, and foster innovative approaches.

Olli Kallioniemi is the Founding Director of the SciLifeLab & Wallenberg Data-Driven Life Science (DDLS) Program and served as Director of SciLifeLab from 2015 to 2024. He is a Professor of Molecular Precision Medicine at Karolinska Institute (OnkPat) and holds a joint appointment at the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki. He has recently focused on exploring and explaining the opportunities that AI offers for life science research and how AI can benefit every researcher.

Melissa Harrison (EMBL-EBI) – How Europe PMC uses and supports LLM development for research workflows
Europe PubMed Central (Europe PMC), developed by EMBL-EBI, is a free, open-access literature database containing over 45 million life science literature outputs; over 10 million of which are full text. This includes almost a million preprints from 34 different servers. Associated research outputs, such as data, are linked to the literature, which is also enriched with additional persistent identifiers, text mined funding information, and text mined annotations of the articles and supplementary files. Annotations are dictionary-based and are being transitioned to a machine learning approach. This talk will discuss the potential of this transition and will explore how Europe PMC plans to leverage machine learning in the future while maintaining the community’s trust in its curated, open dataset as a reliable resource for scientific research. Words of caution about AI and ghost workers, including biocurators, will also be mentioned.

Melissa Harrison is the Lead of Literature Services at EMBL’s European Bioinformatics Institute (EMBL-EBI). After completing a biology degree at King’s College London she worked in scientific publishing for two decades. In her previous role at eLife she honed her skills in open science policy and implementation and has been instrumental in the propagation of open persistent identifiers and metadata.

Aasa Feragen (DTU) – AI fairness — it doesn’t have to be hard
Aasa Feragen is a Professor in Medical Image Analysis at the Technical University of Denmark (DTU).

Martin Eklund (KI) – Limitations of foundation models for achieving optimal performance
Foundation models are undoubtedly highly useful. But are they a panacea for advancing performance of deep learning systems? If not, what are their limitations? In the presentation, we explore these questions using large and rich digitized prostate pathology data as an example.

Martin Eklund is professor of epidemiology at the Department of Medical Epidemiology and Biostatistics where he focusses his research on reducing the mortality of prostate cancer as well as the negative side effects of today’s imprecise diagnostics and treatment selection. He works a lot on development of AI systems for clinical decision making.

Prashant Singh (UU) – AI and Optimization for Science: Principles and Pitfalls
Data-driven science has emerged as a modern pillar of science, complementing theory, experiments and computational approaches. Scientific workflows – from design of experiments to data analysis, have greatly benefited from tools and techniques from various fields including optimization, statistics, computational science, etc. In this talk, we will motivate principled approaches for various stages of the scientific research pipeline, from traditional foundations such as optimization, to recent AI-based advances such as large-language models.

Prashant is an Assistant Professor, and a SciLifeLab fellow hosted at the Department of Information Technology, Science for Life Laboratory, Uppsala University. His research interests involve developing machine learning and optimization methods to enable fast, data-efficient analysis and processing of scientific data, particularly in the domain of life sciences.

Phil Ewels (Seqera) – Building and testing scientific workflows with LLMs and AI agents
Nextflow has become the leading tool for scientific workflows in bioinformatics, but writing workflows can be challenging. This talk introduces Seqera AI, a new tool that helps generate Nextflow pipelines either from scratch, from existing scripts, or even other workflow languages. I’ll discuss how Seqera AI is able to generate best-practice DSL2 code that follows nf-core guidelines, and how we go beyond just code generation: creating and running test suites with AI agents, streamlining development while improving code quality and validation.

Phil Ewels is Senior Product Manager for Open Source at Seqera, working with Nextflow, MultiQC, nf-core and Wave. Before joining Seqera in 2022, Phil worked at the National Genomics Infrastructure (NGI) at SciLifeLab in Stockholm, Sweden. It was through this work that Phil became involved with Nextflow and eventually co-founded the nf-core community. Phil’s career has spanned many disciplines from lab work and bioinformatics research in epigenetics, through to software development and community engagement. He is the author of MultiQC, SRA-Explorer, QCFail.com, and has a PhD in Molecular Biology from the University of Cambridge, UK.

Program

Automation_of_research_workflows_March_6_programmeDownload

CBGE & DDD Roadshow in Lund | From Decoding Biology to Drug Discovery
2025-03-05 11:00 - 15:00 | Belfragesalen, BMC D15, Klinikgatan 32, Lund, Sweden
SciLifeLab Lund is pleased to welcome SciLifeLab Chemical Biology & Genome Engineering Platform (CBGE) and Drug Discovery and Development Platform (DDD) and host their Roadshow in Lund.

During the seminar “Small Molecules, CRISPR & Chemical Proteomics: From Decoding Biology to Drug Discovery”, we will have a look into both platforms and an user will showcase a project carried out in collaboration with them. The Seminar will be followed by a light lunch and individual consultation meetings.

Register here!

In this seminar:

The SciLifeLab Chemical Biology & Genome Engineering Platform

Anna-Lena Gustavsson, Platform director, KI

Fredrik Ek, Chemical Biology Consortium Sweden, LU

Bernhard Schmierer, CRISPR Functional Genomics, KI

Massimiliano Gaetani Chemical Proteomics, KI

The SciLifeLab Drug Discovery and Development Platform

Per Arvidsson, Platform director, KI

User presentation

Functional chemical reprogramming of cancer cells to induce antitumor immunity. Fábio Fiúza Rosa. Co-founder and Head of Research, Asgard Therapeutics AB, prev. Filipe Pereira research group LU.

Campus Solna Seminar Series: Osheen Sharma & Solenne Bleuse
2025-02-27 12:00 - 13:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Osheen Sharma

Brinton Seashore-Ludlow – alpha 4

Evaluating Feature Extraction in Ovarian Cancer Cell Line Co-Cultures Using Deep Neural Networks

Solenne Bleuse

Ola Larsson – gamma 5

Stiffness dependent translation in cancer

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

SciLifeLab Lund Seminar Series | DST
2025-02-26 15:00 - 16:00 | Belfragesalen, BMC D15, Klinikgatan 32, Lund, Sweden
Welcome to the SciLifeLab Lund seminar series!

These seminars are designed to highlight SciLifeLab Lund, our cutting-edge research infrastructure, and the diverse resources available to the scientific community.

In the 5th seminar, we will have a look into the Display & Selection Technologies unit (DST) which is part of the SciLifeLab Drug Discovery & Development platform. The DST unit supports the development of therapeutic antibodies and single domain antibodies.

Mikael Mattsson (DST’s Head of Unit) will present the unit, and Carl Sandén (Division of Clinical Genetics at Lund University) will will showcase a project carried out in collaboration with the facility.

Please note that the seminars are site only but the recordings are available HERE.

Registration

Register for the next seminars!

26th March 2025 | Lund University Bioimaging Centre (LBIC)

Register Seminar March

23rd April 2025 | Lund Protein Production Platform

Register Seminar April

28th May 2025 | National Bioinformatics Infrastructure (NBIS)

Register Seminar May

18th June | Structural Proteomics

Register Seminar June

PULSE Challenge: ML/AI approaches for designing proximity-inducing small molecules – PROTAC cell permeability and bioavailability
2025-02-25 12:00 - 13:00 | Online event via Zoom
The seminar series PULSE Challenge is connected to the MSCA co-funded* postdoctoral program SciLifeLab PULSE, that will train 48 future leaders in life sciences. The program focuses on innovative, fundamental and translational research carried out in supportive and diverse academic and industrial environments, preparing postdocs with necessary skills for long-term career sustainability. Click HERE to find out more about SciLifeLab PULSE

On-line event via Zoom

Register Here

Presenters: Prof. Jan Kihlberg & Assoc. prof. Vasanthanathan PoongavanamUppsala University, Sweden

Abstract:Most PROTACs which have a “druglike” oral bioavailability (>5%) are based on a CRBN E3-ligase ligand, but a few VHL PROTACs also display >5% bioavailability. Use of 2D descriptors places oral drugs, CRBN and VHL PROTACs in different parts of chemical space, while the use of 3D descriptors indicates that the chemical spaces overlap. Use of 3D descriptors may therefore enhance the probability of discovering PROTACs with satisfactory oral bioavailability

We have studied CRBN and VHL PROTACs by NMR spectroscopy and MD simulations. These studies revealed that the propensity of the PROTACs to adopt folded and semi-folded conformations with low solvent – accessible 3D polar surface area correlated to higher cell permeability. The length, chemical nature and flexibility of the linker was found to be essential for allowing intramolecular hydrogen bonds, π–π interactions and van der Waals interactions to stabilize (semi)folded conformations for permeable PROTACs in a membrane-like environment.

Use of MD simulations for prediction of the conformations and properties of PROTACs is time consuming. However, classification models that were developed by machine learning using 2D descriptors allowed differentiation between VHL PROTACs that had high or low cell permeability. Such models can be integrated as effective filters to prioritize PROTACs for synthesis in the design process. Nevertheless, certain challenges remain, including the imbalanced nature of datasets, and model interpretability. Addressing these limitations in future studies will be crucial for maximizing the full potential of machine learning in PROTAC design.

Biographies:Jan Kihlberg holds a chair in Organic Chemistry at Uppsala University, Sweden since 2013. His key research interests are to understand what properties convey cell permeability, aqueous solubility and target binding to drugs such as PROTACs and macrocycles in the beyond rule of 5 space and to translate this knowledge into guidelines for design. He has published more than 200 peer–reviewed publications and book chapters. He establishing his independent research group at Lund University in 1991, became full professor in Bioorganic Chemistry at Umeå University in 1996, then moved to AstraZeneca R&D in Gothenburg in 2003 while maintaining a research group at Umeå University. At AstraZeneca Prof. Kihlberg held the role as Director, Head of Medicinal Chemistry for seven years.

Vasanthanathan Poongavanam is a computational chemistry and AI expert at the DDD Platform, SciLifeLab, Uppsala University, Sweden. His research focuses on applying computational chemistry and AI methodologies to accelerate drug discovery projects. He has authored more than 60 scientific publications, including research articles, reviews, and book chapters.

Policing secretion: cargo capture into ER-derived vesicles initiates secretion
2025-02-21 10:00 - 11:00 | Gamma 7 Lunchroom, Tomtebodavägen 23A, Solna, 17121
Visiting Professor Liz Miller from the Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Scotland UK, will give a seminar at SciLifeLab Campus Solna. The seminar should be of particular interest to cell and structural biologists interested in membrane associated processes operating during the early stages of the secretory pathway.

Background

One third of the proteins encoded in eukaryotic genomes pass through the secretory pathway, entering via the endoplasmic reticulum (ER). The Miller lab has made pivotal contributions, dissecting the molecular mechanisms operating during the early stages of ER-associated secretory protein biogenesis. Specifically, the research has focused on understanding protein quality control and export from the ER. The lab has exploited the budding yeast, Saccharomyces cerevisiae, as a model system, taking advantage of the full spectrum of biochemical, genetic, genomic and proteomic tools, including cryo-EM. The research has defined mechanisms relevant to a number of human diseases, most notably cystic fibrosis and similar diseases of protein misfolding. Recently, the Miller lab has been examining how secretory cargo is selected for ER export in human cells, which will be the focus of her talk here at SciLifeLab Campus Solna.

Biography

Professor Liz Miller carried out her PhD in Melbourne, Australia, working on intracellular traffic of plant defence proteins. In 1999, as a Jane Coffin Childs Postdoctoral Fellow, she joined Randy Schekman’s lab (note: prior to his Nobel Prize awarded in 2013) at the University of California, Berkeley. In the Schekman lab, Liz established the mechanistic basis for capture of nascent secretory proteins into ER-derived COPII vesicles. In 2005 Liz established her independent lab at Columbia University in New York, and after 10 years moved to become a Programme Leader/MRC Investigator at the MRC Laboratory of Molecular Biology in Cambridge, where she maintains a small lab. In 2023, Liz joined the Division of Molecular, Cell and Developmental Biology within the School of Life Sciences in 2023.

Read more
https://www.dundee.ac.uk/people/liz-miller

https://www2.mrc-lmb.cam.ac.uk/group-leaders/h-to-m/liz-miller

Host: Per Ljungdahl, per.ljungdahl@scilifelab.se

Campus Solna Seminar Series: Xue Zhang & Elisabeth Söderberg
2025-02-20 12:00 - 13:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Xue Zhang

Bennie Lemmens – alpha 5

Nanoscale view on genome instability

Elisabeth Söderberg

Per-olof Syren – gamma 5

Enzyme catalysis as a tool in monomer synthesis

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

[The Svedberg seminar]-Imaging the molecular processes of cell division across scale
2025-02-19 15:15 - 16:15 | BMC Lecture hall A1:107a, BMC, Husargatan 3, Uppsala, Sweden
Jan EllenbergProfessor Karolinska Institutet Stockholm, Sweden and European Molecular Biology Laboratory, Heidelberg, Germany Director, Science for Life Laboratory, Sweden

THE LENNART PHILIPSON MEMORIAL LECTURE2025

Lecture hall A1:107a, BMC, Uppsala University Wednesday, February 19, 2025 at 3:15 pm

Bio

Prof. Jan Ellenberg Professor Ellenberg is renowned for his groundbreaking research in cell biology, particularly in the areas of advanced imaging and the study of cell division. His approach of the so-called 4D dynamic change of molecular structures in living cells, studied in individual, and all the way into cells, embedded in organismal tissues has generated new insight and opened immense technological potential. Dr. Ellenberg has been a group leader at the European Molecular Biology Laboratory (EMBL) since 1999, the head of the Gene Expression Unit between 2006-2010 and the head of the Cell Biology and Biophysics Unit since 2010. He has been coordinating infrastructure development within EMBL and at the European level. Since July 2024, Dr. Ellenberg has been acting as the Director of SciLifeLab in Sweden, became Professor at Karolinska Institutet and an Affiliated Professor at Stockholm University and KTH Royal Institute of Technology. A single (!) representative publication out of the long series of top articles published by Ellenberg and his group highlights the essence of this year’s Lennart Philipson Memorial lecture: Gerlich D, Ellenberg J. 4D imaging to assay complex dynamics in live specimens. Nat Cell Biol. 2003; Suppl: S14-9. Welcome!

PULSE Challenge: Properties and challenges with therapeutic oligonucleotides illustrated by hybridization-dependent off-target assessment
2025-02-19 15:00 - 16:30 | Online event via Zoom
This presentation will describe this workflow and discuss considerations for various ONT classes, emphasizing the importance of ONT-specific factors such as chemistry, delivery systems, and tissue distribution in OffT evaluation. It will also cover strategies for experimental verification and risk assessment and discuss the potential of machine learning models to enhance OffT prediction.

The seminar series PULSE Challenge is connected to the MSCA co-funded* postdoctoral program SciLifeLab PULSE, that will train 48 future leaders in life sciences. The program focuses on innovative, fundamental and translational research carried out in supportive and diverse academic and industrial environments, preparing postdocs with necessary skills for long-term career sustainability. Click HERE to find out more about SciLifeLab PULSE

On-line event via Zoom

Register Here

Presenter: Dr Patrik Andersson, PhDSenior Director, RNA Therapeutics SafetyAstraZeneca, Gothenburg, Sweden

Abstract:Hybridization-dependent off-target (OffT) effects, occurring when oligonucleotides bind via Watson-Crick-Franklin hybridization to unintended RNA transcripts, remain a critical safety concern for therapeutic oligonucleotides (ONTs). Despite the importance of OffT assessment of clinical trial ONT candidates, formal guidelines were for many years lacking, with only brief mentions in Japanese regulatory documents (2020) and FDA recommendations for HBV (hepatitis B virus) treatments (2022). A subcommittee of the Oligonucleotide Safety Working Group (OSWG), was formed to gather experiences and develop updated industry recommendations for assessing OffTs of ONTs. The proposed workflow encompasses five key steps: 1) OffT identification through in silico complementarity prediction and transcriptomics analysis, 2) focus on cell types with relevant ONT activity, 3) in vitro verification and margin assessment, 4) risk assessment based on the OffT biological role, and 5) management of unavoidable OffTs.

This presentation will describe this workflow and discuss considerations for various ONT classes, emphasizing the importance of ONT-specific factors such as chemistry, delivery systems, and tissue distribution in OffT evaluation. It will also cover strategies for experimental verification and risk assessment and discuss the potential of machine learning models to enhance OffT prediction.

Biography:Patrik joined AstraZeneca in Gothenburg, Sweden 2004 as “Discovery Toxicologist”, leading the safety work from target identification to candidate selection for numerous projects. From 2012, he developed into an expert in the safety of nucleotide-based drugs and their delivery. This includes leading the non-clinical safety work internally at AstraZeneca and in collaborations with world leading companies in the fields of antisense oligonucleotides and therapeutic mRNA. Author of several peer reviewed primary and review papers and book chapters in the area of preclinical safety assessment of oligonucleotide therapeutics and active member in several cross-industry collaboration groups. Most recently active member of the EFPIA/PDEG and IQ/DruSafe oligo working groups and leading the OSWG subcommittee that resulted in a recently accepted paper on revised industry recommendations for off-target safety assessment (DOI: 10.1089/nat.2024.0072)

In vivo site-specific engineering to reprogram human T cells
2025-02-18 15:15 - 16:15 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Spotlight seminar series welcomes the newly recruited SciLifeLab Fellow William Nyberg to present his research in Air&Fire Campus Solna on February 18th.

William Nyberg, PhD, is a newly appointed principal investigator at the Karolinska Institute. Building on scientific discoveries as a postdoc in Justin Eyquem’s research lab at UCSF, his lab focuses on reprogramming T cells in vivo using advanced genetical engineering for therapeutic purposes. This is done primarily with the use of CARs, but are also exploring the use of other synthetic receptors and therapeutic TCR sequences to develop new T cell therapies against cancers. In 2023, he was honored with the Excellence in Research Award by the ASGCT and joined the Karolinska Institute and Science for Life Laboratory in 2024 to pursue his research.

Abstract

Engineered T cells, reprogrammed to express chimeric antigen receptors (CAR) or T cell receptors (TCR), have transformed cancer treatment and are being explored as therapeutics for autoimmune disorders and infectious diseases. Enhancing T cell function through genome editing—either by disrupting endogenous genes or precisely inserting DNA payloads—has shown significant promise. However, the ex vivo manufacturing process is lengthy, costly, and requires pre-conditioning, limiting the accessibility of these therapies. In vivo generation of CAR-T cells could overcome these barriers. In this presentation, I will demonstrate that stable and cell-specific transgene expression can be achieved through in vivo site-specific integration of large DNA payloads. We developed a two-vector system to deliver CRISPR-Cas9 ribonucleoproteins (RNPs) and a DNA donor template, using enveloped delivery vehicles (EDVs) and adeno-associated virus (AAVs), respectively. By integrating a CAR transgene into a T cell-specific locus we generated therapeutic levels of CAR-T cells in a humanized mouse model in vivo. These findings offer a promising pathway to more efficient, precise, and widely accessible T cell therapies.

CSI Seminar: Sleep Hygiene & Habits - invited talk by Ikaro Beraldo
2025-02-18 14:00 - 14:30 | Gamma 2 Lunchroom, SciLifeLab, Tomtebodavägen 23, Solna, Sweden
Struggling with restless nights and low energy during the day? Sleep quality is influenced by daily habits, not just the number of hours spent in bed. This seminar will explore the impact of routines, environment, and common misconceptions on sleep. Practical strategies will be discussed to improve rest, boost focus, and enhance overall well-being. Understanding sleep hygiene can lead to better mood, productivity, and long-term health. Small changes can make a big difference in achieving deeper, more restorative sleep.

We will begin with a ~ 20 min talk, held in Solna and over zoom. Then proceed with a reflection and discussion held only on-site. We encourage other sites to form watch parties, by listening in together to the talk and then hold their own discussion afterwards. Hopefully seeding many local chapters of CSI.

To help facilitate discussion and reflection, consider the following starter questions:

Awareness: where do we experience sleep habits in our lives?

Analysis: how do I currently interact with sleep hygiene?

Alternative: how could we relate to sleep habits, in ourselves and others?

Action: how will knowledge of sleep hygiene change my decisions going forward?

Multimodal Imaging: Optimized Workflows for Improved Efficiency and Precision
2025-02-18 12:00 - 13:00 | Glasburen Seminar Room, Chemical Biological Centre (KBC) Building, Umeå University, Umeå, 901 87, Sweden
This seminar talk is part of the SciLifeLab site Umeå/KBC Infrastructure Seminar series. The seminar series is held in Glasburen at KBC, Umeå, and online attendance is available via Zoom (link provided upon registering).

Presenter: Cecilia Fager, PhD, Electron Microscopy Product and Application Specialist, ZEISS NordicsAbstract: As the complexity of scientific questions increases, approaches to address them are developed. One of the recent trends is the use of multimodal imaging where different microscopy techniques are used in combination to generate more detailed insights about a particular specimen. This seminar shows how multimodal imaging can be used to optimize the workflow for improved efficiency and precision.

Read more and register

SciLifeLab Site Umeå/KBC Infrastructure Seminar Series

This event is part of the SciLifeLab site Umeå/KBC Infrastructure Seminar series, for future events in spring 2025, check the seminar series home page

Take me there

Is UMAP accurate? Addressing some fair and unfair criticism.
2025-02-14 10:00 - 11:00 | Online event via Zoom
Nikolay Oskolkov, NBIS, Lund University

NBIS and SciLifeLab Data Centre arrange an open SciLifeLab AI Seminar Series aimed at knowledge-sharing about Artificial Intelligence and applications in the Life Science community. The seminar series is open to everyone. The seminar is run over Zoom on the third Friday of the month during academic terms, typically between 10 and 11 am, with approx. 45 min presentation and 15 min discussion.

Abstract

UMAP is a golden standard dimensionality reduction method in single cell biology, yet it has a controversial reputation and is sometimes heavily criticized, see for example [1 – 5]. In particular, the recent Nature publication of All of Us program [6] gave rise to an avalanche of discussions in scientific community regarding the controversial UMAP figure of human populations suggesting that UMAP is not accurate for this purpose. Remarkably, the main criticism of UMAP originates (to the best of my knowledge) from the population genomics community, wile the single cell community seems to be satisfied with the quality of UMAP analysis.

In this talk I will discuss peculiarities of data in single cell and population genomics analyses, and explain some insights from the UMAP algorithm, which could potentially attempt to resolve the contradiction between the two communities and very different research questions studied by the communities. I will also cover the foundations of PCA + tSNE + UMAP algorithms and emphasize their pros and cons for different types of data in Life Sciences.

[1] https://simplystatistics.org/posts/2024-12-23-biologists-stop-including-umap-plots-in-your-papers/[2] https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011288[3] https://x.com/jkpritch/status/1759769445759893832?lang=en[4] https://www.nature.com/articles/d41586-024-00568-w[5] https://www.science.org/content/article/huge-genome-study-confronted-concerns-over-race-analysis[6] https://www.nature.com/articles/s41586-023-06957-x

Slides

Download slides (PDF)

Campus Solna Seminar Series: Serhat Aktay & Anna Toldra Filella
2025-02-13 12:00 - 13:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Serhat Aktay

Anniina Vihervaara – alpha 3

Mapping the functional genomic landscape de novo with divergent transcription analysis of PRO-seq data

Anna Toldra Filella

Vicent Pelechano – gamma 5

Towards point-of-care nucleic acid testing

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

Biomarkers from discovery to clinical practice
2025-02-12 13:00 - 14:00 | Gamma 7 Lunchroom, Tomtebodavägen 23A, Solna, 17121
Welcome to Professor Leonidas Alexopoulos‘s seminar (National Technical University of Athens and Protavio Ltd.)

who will share his experience about diseasebiomarkers from discovery to clinical practice providing both an academic and industryperspective.

When: February 12th 2025 at 1 pm Where: SciLifeLab, Lunch Room Gamma-7

Translating a multiplex biomarker discovery project to clinical practice is a comprehensive process necessitating strong research and business aptitude. As a professor in Systems Bioengineering at the National Technical University of Athens and as an entrepreneur and co-founder of Protavio, a multiplex biomarker company using Luminex and Olink technologies, I have seen both worlds of research and commercialization. Bridging the gap between the two worlds is of utmost importance to amplify the impact of academic research beyond traditional academic accolades such as paper citations and h-index. This talk will encapsulate insights from approximately 150 biomarker projects undertaken by Protavio in the last decade and discuss important aspects of improving the research-to-clinic biomarker translation. Several important aspects of this process will be discussed that span beyond assay development and clinical validation and include: commercialization plan, platform selection, software development, stakeholder analysis, IVDR / regulatory requirements, reimbursement strategy, intellectual property basics, and stringent GMP and ISO13485 production. By understanding the importance of these elements holistically, researchers will be in a better position to assess the commercialization potential and clinical usability of their multiplex biomarker projects.

Changes and Challenges through the Ages
2025-02-11 12:30 - 15:30 | BMC Room B7:101a, Husargatan 3, Uppsala
Be part of an empowering and enlightening discussion featuring trailblazing Women in Research as we celebrate International Day of Women and Girls in Science on February 11 at BMC, Uppsala, in room B7:101a.

This panel brings together accomplished research professionals to share their journeys, challenges, and triumphs in breaking barriers and advancing innovation.

Organizer: Vijay Sai Josyula, Christoffersson Lab, Uppsala University, in cooperation with SciLifeLab Site Uppsala.

Guest Speakers

Keynote speaker. Prof. Mia Phillipson

Dr. Gabriela Montejo-Kovacevich

Dr. Kaska Koltowska

Dr. Jessica Nordlund

Dr. Amy Turner (Proteintech)

Program

12:30 Welcome

12:45 Introduction to the company Proteintech

13:00 Keynote speaker Prof. Mia Phillipson

13:30 Dr. Gabriela Montejo-Kovacevich

13:45 Dr. Kaska Koltowska

14:00 Break / Networking session

14:10 Dr. Jessica Nordlund

14:25 Dr. Amy Turner, Proteintech

14:40 Panel Discussion

15:30 Closing statements

Registration

Navigating the Research Data Landscape: Publication Practices at a Swedish university
2025-02-11 11:00 - 12:00 | Online event via Zoom
Researchers are increasingly expected by governments, funders, journals, and institutions to make their research data accessible online. The aim of the Swedish government is that such practices should be implemented by 2026. However, little is known about whether, how, and where researchers publish or share their data. This seminar will focus on the results of a study looking at the state of open and FAIR data publication practices of Stockholm University researchers.

When: Tuesday, February 11 2025, 11-12 CET (Zoom)

Speakers: Maria Almbro, Stockholm University

Link to recording on YouTube

Link to presentation slides

More info
SciLifeLab Data Management seminar series is an event series by the SciLifeLab Data Centre and NBIS joint Data Management team aimed at both the life science research community and infrastructure and others with an interest in research data management in life sciences. The events will showcase how to put the FAIR principles and good data management into practice. The goal of the events in this seminar series is to provide interesting seminars around topics related to research data management in general and to foster discussions around best practices and how they can be improved. The events take place virtually (over Zoom) and are open to everyone (researchers, staff, RDM professionals, etc.) working at or affiliated with a Swedish research institute or university. Each event is scheduled for 60 minutes, including 15 minutes for discussions and Q&A. The videos will be published openly after the seminars at the SciLifeLab YouTube channel.More information about SciLifeLab Data Centre and NBIS joint Data Management team: https://data-guidelines.scilifelab.se/

Welcome!Organisers: SciLifeLab Data Centre and NBIS National Bioinformatics Infrastructure SwedenFor more information or inquiries, please contact: data-management@scilifelab.se

Basic Course in Scanning and Transmission Electron Microscopy (SEM/TEM)
2025-02-11 08:00 - 2025-02-13 17:00 | KBC Building Umeå, Linneaus Väg 6, Umeå
This course covers lectures and practical demonstrations in SEM and TEM techniques. The contents include principles of electron microscopy, specimen preparation, cryo-electron microscopy and correlative light-electron microscopy. The main focus will be on imaging biological samples, but the course may also be suitable for material scientists interested in high-resolution electron microscopy.Course overview

Application deadline:28 January 2025

Location:Lectures at the KBC Building and laboratory demonstrations at UCEM.

Participants:18 persons

Instructors:UCEM staff

Duration:3 days

Breaks/Refreshments:Coffee, cookies and fruit.

Costs:No course fee, but full attendance is required!

Examination/Credits:Oral and practical examinations are conducted during laboratory demonstrations. A course certificate will be given after participants attend all lectures and laboratory demonstrations for this 3-day course. UCEM recommends PhD program examiners to give 1 ECTS after successful participation.

[The Svedberg seminar] - On giant lungfish genomes and the genomics of adaptations and speciation in hyperdiverse cichlid fish radiations
2025-02-10 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Axel MeyerProfessorUniversity of Konstanz, Germany

Bio

Axel Meyer (*1960 in Lübeck) studied biology at the Universities of Marburg and Kiel in Germany before he moved to the USA in 1982. At the University of California he received his Master (1985) and PhD (1988) degrees in Berkeley’s Department of Zoology. For the last year of his PhD he worked in the Biochemistry Department in lab of Allan C. Wilson at Berkeley. There he was part of a team that was the first to use PCR for questions in molecular evolution, phylogenetics, and ancient DNA. As an Alfred P. Sloan Postdoc he continued to work with Allan Wilson in the Biochemistry Department at Berkeley until 1990 when he became an Assistant and then (since 1993) Associate Professor in the Ecology and Evolution Department at Stony Brook, NY. In 1997 he returned to Germany as Chair in Zoology and Evolutionary Biology at the University of Konstanz. He is a member of several academies, including EMBO, the Academia Europaea, the Berlin Academy of Sciences, the German National Academy Leopoldina, and The American Academy of Arts and Sciences and received a numerous awards and fellowships including Fulbright and Guggenheim Fellowships, the Carus Medal of the Leopoldina, and a Hector Prize. Axel Meyer’s research focuses on fundamental questions in evolutionary biology and comparative genomics with a focus on speciation, Hox genes, genomics of adaptations, and gene and genome duplications. He was among the first to confirm Susumo Ohno’s suggestion that all modern fishes are derived from a lineage that experienced an additional (the teleost-specific genome duplication, TSGD) genome duplication. Meyer received the EMBO award for communications in the life sciences for his efforts to communicate science to the public. He has a science podcast for Cicero Magazin, wrote a popular science book on the biology of men and women, and had a weekly column for the financial newspaper Handelsblatt. Besides Konstanz he is affiliated with the SCSIO in Guangzhou and the Museum of Comparative Zoology at Harvard University

On giant lungfish genomes and the genomics of adaptations and speciation in hyperdiverse cichlid fish radiations

Lungfishes are the closest living relatives to tetrapods among the “fishes”. Their genomes are the largest animal genomes, composed of over 90% repetitive DNA, and their size, 3-15x larger than the human genome (~45-92Gb), makes them difficult to assemble and interpret. The analyses of these genomes revealed the genetics of some pre-adaptations (respiration, locomotion, nitrogen excretion, olfaction) that might have permitted their relatives to conquer land in the Devonian and to give rise to all land vertebrates. While lungfishes are ancient “living fossils” that appear not have changed for >100 Million years, the cichlid fishes of the East African Great lakes and of Nicaragua’s crater lakes have speciated and morphologically diversified at record speeds. New species formed within a few hundred generations and several phenotypic innovations evolved repeatedly and due to structural variants and transposable element activity.

Host: Dan Larhammar dan.larhammar@uu.se, Per Ahlberg Per.Ahlberg@ebc.uu.se, UU

Chameleon Workshop
2025-02-10 08:00 - 2025-02-14 17:00 | SciLifeLab Campus Solna, Tomtebodavägen 23 A, Solna, Sweden
Chameleon workshop – a practical workshop to give the opportunity to the attendants to check their own samples and start familiarising with the machine.

This is a fully practical course to give attendants the opportunity to get to know what can be obtained using the Chameleon for cryo-EM sample preparation, how to use the machine and give it a go with their own samples. It is organised according to the schedule below.

registration

The first day will be open to all applicants for a presentation and a demo from the Chameleon team. The following four days will be organised in personalised training/demo sessions. We will choose 8 samples from all applications and every day we will run 2 samples with groups of maximum 4 people (due to space restraints). If you are interested please read carefully the attached document.

Campus Solna Seminar Series: Alexandra Firsova
2025-02-06 12:00 - 13:00 | Milkyway SciLifeLab Solna, Tomtebodavägen 23, Solna
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Alexandra Firsova

Christos Samakovlis – gamma 4

A single cell-resolution topographic atlas of the adult human lung and its application in diseased state.

Erik Sonnhammer – gamma 7

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

AIMday Precisionsmedicin
2025-02-06 09:00 - 13:00 | Navet, SciLifeLab Uppsala, SciLifeLab Uppsala, BMC C11, Husargatan 3, Uppsala, 75237, Sweden
Tid: 6 februari 2025, 09:00-13:00Plats: Biomedicinskt centrum (BMC), Navet, Husargatan 3, entré C11, Uppsala

Main Event Website and Registration

Är du intresserad av precisionsmedicin och vill bidra till att nya lösningar utvecklas och implementeras i hälso- och sjukvården?

Precisionsmedicinskt centrum Uppsala (PMCU) och SciLifeLab bjuder gemensamt in till AIMday Precisionsmedicin. Utifrån kliniska behov och frågeställningar inom området precisionsmedicin bjuder vi in dig som representant från hälso- och sjukvården, akademin eller näringslivet att diskutera med oss. Vi ser fram emot att höra tankar från ditt perspektiv om hur vi skulle kunna ta oss an dessa frågeställningar tillsammans och hoppas på många inspirerande diskussioner.

AIMday är ett utbyte av kunskap och idéer, inriktade på att hitta nya tillvägagångssätt för verkliga utmaningar. Tanken är helt enkelt att en bred blandning av kompetenser och aktörer kan ge olika perspektiv och kanske även nya vägar för att lösa utmaningar och idéer – och därigenom skapa gynnsamma förutsättningar för fortsatt samarbete mellan bland annat hälso- och sjukvården, universitetet, SciLifeLab och företag.

Jobbar du med precisionsmedicin och vill diskutera ett behov eller frågeställning?

Välkommen att anmäla dig till de frågeställningar som kommit in från hälso- och sjukvården. Sista dag för anmälan är 20 januari 2025.

Main Event webiste

Parallella workshops kommer hållas i AIMday format (60 min per frågeställning) och du anmäler dig till den eller de frågeställningar du helst vill vara med och diskutera. Målet med dagen är att skapa förutsättningar för nya idéer och samverkansmöjligheter, med syfte att förbättra framtidens hälso- och sjukvård inom området precisionsmedicin.

Exempel på områden inom precisionsmedicin som kan diskuteras:

Precisionsdiagnostik

Precisionsbehandling, tex. läkemedel och medicinteknik

Hälsoekonomi

Hälsodata

Avbildningstekniker, tex. PET

AI och digitala lösningar

Att delta på AIMday är kostnadsfritt för alla deltagare – vi bjuder på enklare lunch.

Kontakta oss om du har frågor:

Therese Fagerqvist, therese.fagerqvist@uu.seTheodora Kunovac Kallak, theodora.kunovac_kallak@uu.seÅsa Johansson, asa.johansson@igp.uu.seEva Berglund, eva.berglund@scilifelab.uu.se

Här kan du läsa mer om PMCU Precisionsmedicin | Akademiska och om SciLifeLab Precision Medicine – SciLifeLab

Uppsala universitet i samarbete med SciLifeLab och Precisionsmedicinskt centrum Uppsala (PMCU)

Liquid biopsy-based biomarker analysis in basic research and clinical applications
2025-02-04 09:00 - 17:00 | Arvid Carlsson Lecture Hall, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 3, Gothenburg, Sweden
The field of liquid biopsy analysis is quickly expanding across several medical and research areas. To support this growth and foster collaboration, we invite you to an interactive seminar focused on the use of liquid biopsies in both basic research and clinical practice.

Event Highlights:

Short presentations on various liquid biopsy analytes, including DNA, RNA, and proteins.

Open slots for additional presentations of liquid biopsy projects

Details:

Cost: Free of charge for confirmed registrants, including lunch and coffee breaks. However, a no-show fee of 1000 SEK will be charged for absentees.

Sponsors: Wallenberg Centre for Molecular and Translational Medicine, RISE, Västra Götalandsregionen, and SciLifeLab Gothenburg.

Organizing Committee:

Anders Ståhlberg – Wallenberg Centre for Molecular and Translational Medicine & Sahlgrenska Center for Cancer Research, University of Gothenburg

Joakim Håkansson – RISE

Maria Smedh – SciLifeLab and Core Facilities, University of Gothenburg

Join us for an informative day of insights, networking, and knowledge-sharing!

Program:

Liquid biopsy Day_2025_ProgramDownload

Registration

Registration Deadlines:

General Registration: January 21, 2025

Deadline for Talk Proposals: December 1, 2024

There are limited spots available, allocated on a first-come, first-served basis. Once these spots are filled, a waiting list will be implemented.

This effort and seminar day is supported by RISE, SciLifeLab Gothenburg, Västra Götalandsregionen and Wallenberg Centre for Molecular and Translational Medicine at University of Gothenburg.

Swedish Oikos Meeting 2025
2025-02-03 08:30 - 2025-02-05 17:00 | Swedish Museum of Natural History, Frescativägen 40, Stockholm, Stockholm, 114 18, Sweden
The Swedish Oikos Meeting 2025 will be held in Stockholm and will gather researchers and students from across Sweden to share ideas and discoveries in ecological research, and solutions for our changing world. A diverse range of topics will be covered, ranging from genes to ecosystems, in Sweden and beyond.

The Planetary Biology Capability is pleased to be part of the Organization Committee and organize a special session on “Planetary Biology”

Check out the conference website to dive into the program and the invited speakers

Conference website

Planetary Biology pre-meeting workshop: Towards the efficient use of molecular approaches and infrastructure to accelerate research in the field of Planetary Biology

This workshop aims to enhance connections between the PB research community in Stockholm, SciLifeLab and the Planetary Biology Capability. Discussions will address challenges and opportunities for the efficient use of SciLifeLab’s services to support and accelerate research in the field of Planetary Biology.

Program for the session

15:00 – 15:15 Introduction to the PB concept and Capability leads.

15:15 – 15:45 SciLifeLab Platforms. Discussion on needs and challenges for using SciLifeLab services.

15:45 – 16:00 Flagship Projects at SciLifeLab: Exploring the concept and inviting expressions of interest for collaborative development.

Programme

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Abstract booklet

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Register for the Planetary Biology Workshop
