BEGIN:VCALENDAR VERSION:2.0 PRODID:-//SciLifeLab - ECPv6.15.18//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:https://www.scilifelab.se X-WR-CALDESC:Events for SciLifeLab REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20250330T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20251026T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20260329T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20261025T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250206T120000 DTEND;TZID=Europe/Stockholm:20250206T130000 DTSTAMP:20260408T005540 CREATED:20250109T100500Z LAST-MODIFIED:20250129T153638Z UID:10001431-1738843200-1738846800@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Alexandra Firsova DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nAlexandra Firsova\n\n\n\nChristos Samakovlis – gamma 4 \n\n\n\nA single cell-resolution topographic atlas of the adult human lung and its application in diseased state. \n\n\n\n\n\n\n\n\n\nErik Sonnhammer – gamma 7 \n\n\n\n \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-rekha-tripathi-mateusz-garbulowski/ LOCATION:Milkyway SciLifeLab Solna\, Tomtebodavägen 23\, Solna CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_123412496_HDR2-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250210T080000 DTEND;TZID=Europe/Stockholm:20250214T170000 DTSTAMP:20260408T005540 CREATED:20250109T134216Z LAST-MODIFIED:20250110T111623Z UID:10001449-1739174400-1739552400@www.scilifelab.se SUMMARY:Chameleon Workshop DESCRIPTION:Chameleon workshop – a practical workshop to give the opportunity to the attendants to check their own samples and start familiarising with the machine. \n\n\n\nThis is a fully practical course to give attendants the opportunity to get to know what can be obtained using the Chameleon for cryo-EM sample preparation\, how to use the machine  and give it a go with their own samples. It is organised according to the schedule below.  \n\n\n\nregistration\n\n\n\n\n\n\n\nThe first day will be open to all applicants for a presentation and a demo from the Chameleon team. The following four days will be organised in personalised training/demo sessions. We will choose 8 samples from all applications and every day we will run 2 samples with groups of maximum 4 people (due to space restraints).  If you are interested please read carefully the attached document. URL:https://www.scilifelab.se/event/chameleon-workshop/ LOCATION:SciLifeLab Campus Solna\, Tomtebodavägen 23 A\, Solna\, Sweden CATEGORIES:Course ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2025/01/Chameleon-scaled.jpg ORGANIZER;CN="Cryo-EM Infrastructure Unit":MAILTO:cryoem_stockholm_lab@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250210T151500 DTEND;TZID=Europe/Stockholm:20250210T161500 DTSTAMP:20260408T005540 CREATED:20250121T074231Z LAST-MODIFIED:20250210T140803Z UID:10001456-1739200500-1739204100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - On giant lungfish genomes and the genomics of adaptations and speciation in hyperdiverse cichlid fish radiations DESCRIPTION:Axel MeyerProfessorUniversity of Konstanz\, Germany \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nAxel Meyer (*1960 in Lübeck) studied biology at the Universities of Marburg and Kiel in Germany before he moved to the USA in 1982. At the University of California he received his Master (1985) and PhD (1988) degrees in Berkeley’s Department of Zoology. For the last year of his PhD he worked in the Biochemistry Department in lab of Allan C. Wilson at Berkeley. There he was part of a team that was the first to use PCR for questions in molecular evolution\, phylogenetics\, and ancient DNA. As an Alfred P. Sloan Postdoc he continued to work with Allan Wilson in the Biochemistry Department at Berkeley until 1990 when he became an Assistant and then (since 1993) Associate Professor in the Ecology and Evolution Department at Stony Brook\, NY. In 1997 he returned to Germany as Chair in Zoology and Evolutionary Biology at the University of Konstanz. He is a member of several academies\, including EMBO\, the Academia Europaea\, the Berlin Academy of Sciences\, the German National Academy Leopoldina\, and The American Academy of Arts and Sciences  and received a numerous awards and fellowships including Fulbright and Guggenheim Fellowships\, the Carus Medal of the Leopoldina\, and a Hector Prize. Axel Meyer’s research focuses on fundamental questions in evolutionary biology and comparative genomics with a focus on speciation\, Hox genes\, genomics of adaptations\, and gene and genome duplications. He was among the first to confirm Susumo Ohno’s suggestion that all modern fishes are derived from a lineage that experienced an additional (the teleost-specific genome duplication\, TSGD) genome duplication. Meyer received the EMBO award for communications in the life sciences for his efforts to communicate science to the public. He has a science podcast for Cicero Magazin\, wrote a popular science book on the biology of men and women\, and had a weekly column for the financial newspaper Handelsblatt. Besides Konstanz he is affiliated with the SCSIO in Guangzhou and the Museum of Comparative Zoology at Harvard University \n\n\n\nOn giant lungfish genomes and the genomics of adaptations and speciation in hyperdiverse cichlid fish radiations\n\n\n\nLungfishes are the closest living relatives to tetrapods among the “fishes”. Their genomes are the largest animal genomes\, composed of over 90% repetitive DNA\, and their size\, 3-15x larger than the human genome (~45-92Gb)\, makes them difficult to assemble and interpret. The analyses of these genomes revealed the genetics of some pre-adaptations (respiration\, locomotion\, nitrogen excretion\, olfaction) that might have permitted their relatives to conquer land in the Devonian and to give rise to all land vertebrates. While lungfishes are ancient “living fossils” that appear not have changed for >100 Million years\, the cichlid fishes of the East African Great lakes and of Nicaragua’s crater lakes have speciated and morphologically diversified at record speeds. New species formed within a few hundred generations and several phenotypic innovations evolved repeatedly and due to structural variants and transposable element activity. \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nHost: Dan Larhammar dan.larhammar@uu.se\, Per Ahlberg Per.Ahlberg@ebc.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-axel-meyer/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250211T080000 DTEND;TZID=Europe/Stockholm:20250213T170000 DTSTAMP:20260408T005540 CREATED:20250107T150231Z LAST-MODIFIED:20250207T091420Z UID:10001426-1739260800-1739466000@www.scilifelab.se SUMMARY:Basic Course in Scanning and Transmission Electron Microscopy (SEM/TEM) DESCRIPTION:This course covers lectures and practical demonstrations in SEM and TEM techniques. The contents include principles of electron microscopy\, specimen preparation\, cryo-electron microscopy and correlative light-electron microscopy. The main focus will be on imaging biological samples\, but the course may also be suitable for material scientists interested in high-resolution electron microscopy.Course overview \n\n\n\nApplication deadline:28 January 2025 \n\n\n\nLocation:Lectures at the KBC Building and laboratory demonstrations at UCEM. \n\n\n\nParticipants:18 persons \n\n\n\nInstructors:UCEM staff \n\n\n\nDuration:3 days \n\n\n\nBreaks/Refreshments:Coffee\, cookies and fruit. \n\n\n\nCosts:No course fee\, but full attendance is required! \n\n\n\nExamination/Credits:Oral and practical examinations are conducted during laboratory demonstrations. A course certificate will be given after participants attend all lectures and laboratory demonstrations for this 3-day course. UCEM recommends PhD program examiners to give 1 ECTS after successful participation. URL:https://www.scilifelab.se/event/basic-course-in-scanning-and-transmission-electron-microscopy-sem-tem-for-life-sciences-2/ LOCATION:KBC Building Umeå\, Linneaus Väg 6\, Umeå CATEGORIES:Course ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2025/01/P1010953-scaled.jpg ORGANIZER;CN="UCEM Ume%C3%A5":MAILTO:hussein.haggag@umu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250211T110000 DTEND;TZID=Europe/Stockholm:20250211T120000 DTSTAMP:20260408T005540 CREATED:20250115T125302Z LAST-MODIFIED:20251125T145533Z UID:10001454-1739271600-1739275200@www.scilifelab.se SUMMARY:Navigating the Research Data Landscape: Publication Practices at a Swedish university DESCRIPTION:Researchers are increasingly expected by governments\, funders\, journals\, and institutions to make their research data accessible online. The aim of the Swedish government is that such practices should be implemented by 2026. However\, little is known about whether\, how\, and where researchers publish or share their data. This seminar will focus on the results of a study looking at the state of open and FAIR data publication practices of Stockholm University researchers. \n\n\n\nWhen: Tuesday\, February 11 2025\, 11-12 CET (Zoom) \n\n\n\nSpeakers: Maria Almbro\, Stockholm University \n\n\n\nLink to recording on YouTube \n\n\n\nLink to presentation slides \n\n\n\nMore info\nSciLifeLab Data Management seminar series is an event series by the SciLifeLab Data Centre and NBIS joint Data Management team aimed at both the life science research community and infrastructure and others with an interest in research data management in life sciences. The events will showcase how to put the FAIR principles and good data management into practice. The goal of the events in this seminar series is to provide interesting seminars around topics related to research data management in general and to foster discussions around best practices and how they can be improved. The events take place virtually (over Zoom) and are open to everyone (researchers\, staff\, RDM professionals\, etc.) working at or affiliated with a Swedish research institute or university. Each event is scheduled for 60 minutes\, including 15 minutes for discussions and Q&A. The videos will be published openly after the seminars at the SciLifeLab YouTube channel.More information about SciLifeLab Data Centre and NBIS joint Data Management team: https://data-guidelines.scilifelab.se/ \n\n\n\nWelcome!Organisers: SciLifeLab Data Centre and NBIS National Bioinformatics Infrastructure SwedenFor more information or inquiries\, please contact: data-management@scilifelab.se URL:https://www.scilifelab.se/event/rdm-seminar-series-publication-practices/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/02/DC_seminar-series_background1-1.png ORGANIZER;CN="Open Science Seminar Series":MAILTO:data-management@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250211T123000 DTEND;TZID=Europe/Stockholm:20250211T153000 DTSTAMP:20260408T005540 CREATED:20250129T095244Z LAST-MODIFIED:20250129T140732Z UID:10001463-1739277000-1739287800@www.scilifelab.se SUMMARY:Changes and Challenges through the Ages DESCRIPTION:Be part of an empowering and enlightening discussion featuring trailblazing Women in Research as we celebrate International Day of Women and Girls in Science on February 11 at BMC\, Uppsala\, in room B7:101a. \n\n\n\nThis panel brings together accomplished research professionals to share their journeys\, challenges\, and triumphs in breaking barriers and advancing innovation. \n\n\n\nOrganizer: Vijay Sai Josyula\, Christoffersson Lab\, Uppsala University\, in cooperation with SciLifeLab Site Uppsala. \n\n\n\nGuest Speakers \n\n\n\n\nKeynote speaker. Prof. Mia Phillipson\n\n\n\nDr. Gabriela Montejo-Kovacevich\n\n\n\nDr. Kaska Koltowska\n\n\n\nDr. Jessica Nordlund\n\n\n\nDr. Amy Turner (Proteintech)\n\n\n\n\n\n\n\n\nProgram\n\n\n\n12:30             Welcome \n\n\n\n12:45             Introduction to the company Proteintech \n\n\n\n13:00             Keynote speaker Prof. Mia Phillipson \n\n\n\n13:30             Dr. Gabriela Montejo-Kovacevich \n\n\n\n13:45             Dr. Kaska Koltowska \n\n\n\n14:00             Break / Networking session \n\n\n\n14:10             Dr. Jessica Nordlund  \n\n\n\n14:25             Dr. Amy Turner\, Proteintech \n\n\n\n14:40             Panel Discussion \n\n\n\n15:30             Closing statements \n\n\n\n\n\n\n\nRegistration URL:https://www.scilifelab.se/event/changes-and-challenges-through-the-ages/ LOCATION:BMC Room B7:101a\, Husargatan 3\, Uppsala CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250212T130000 DTEND;TZID=Europe/Stockholm:20250212T140000 DTSTAMP:20260408T005540 CREATED:20250108T144537Z LAST-MODIFIED:20250108T144539Z UID:10001429-1739365200-1739368800@www.scilifelab.se SUMMARY:Biomarkers from discovery to clinical practice DESCRIPTION:Welcome to Professor Leonidas Alexopoulos‘s seminar (National Technical University of Athens and Protavio Ltd.)  \n\n\n\nwho will share his experience about diseasebiomarkers from discovery to clinical practice providing both an academic and industryperspective. \n\n\n\nWhen: February 12th 2025 at 1 pm Where: SciLifeLab\, Lunch Room Gamma-7  \n\n\n\nTranslating a multiplex biomarker discovery project to clinical practice is a comprehensive process necessitating strong research and business aptitude. As a professor in Systems Bioengineering at the National Technical University of Athens and as an entrepreneur and co-founder of Protavio\, a multiplex biomarker company using Luminex and Olink technologies\, I have seen both worlds of research and commercialization. Bridging the gap between the two worlds is of utmost importance to amplify the impact of academic research beyond traditional academic accolades such as paper citations and h-index. This talk will encapsulate insights from approximately 150 biomarker projects undertaken by Protavio in the last decade and discuss important aspects of improving the research-to-clinic biomarker translation. Several important aspects of this process will be discussed that span beyond assay development and clinical validation and include: commercialization plan\, platform selection\, software development\, stakeholder analysis\, IVDR / regulatory requirements\, reimbursement strategy\, intellectual property basics\, and stringent GMP and ISO13485 production. By understanding the importance of these elements holistically\, researchers will be in a better position to assess the commercialization potential and clinical usability of their multiplex biomarker projects. URL:https://www.scilifelab.se/event/biomarkers-from-discovery-to-clinical-practice/ LOCATION:Gamma 7 Lunchroom\, Tomtebodavägen 23A\, Solna\, 17121 CATEGORIES:Community ORGANIZER;CN="Clauida Fredolini":MAILTO:claudia.fredolini@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250213T120000 DTEND;TZID=Europe/Stockholm:20250213T130000 DTSTAMP:20260408T005540 CREATED:20250109T100715Z LAST-MODIFIED:20250204T153341Z UID:10001432-1739448000-1739451600@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Serhat Aktay & Anna Toldra Filella DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nSerhat Aktay\n\n\n\nAnniina Vihervaara – alpha 3 \n\n\n\nMapping the functional genomic landscape de novo with divergent transcription analysis of PRO-seq data \n\n\n\n\n\nAnna Toldra Filella\n\n\n\nVicent Pelechano – gamma 5 \n\n\n\nTowards point-of-care nucleic acid testing \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-serhat-aktay-eduardo-sagredo/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_124630107_HDR-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250214T100000 DTEND;TZID=Europe/Stockholm:20250214T110000 DTSTAMP:20260408T005540 CREATED:20250207T152508Z LAST-MODIFIED:20250402T084940Z UID:10001482-1739527200-1739530800@www.scilifelab.se SUMMARY:Is UMAP accurate? Addressing some fair and unfair criticism. DESCRIPTION:Nikolay Oskolkov\, NBIS\, Lund University \n\n\n\nNBIS and SciLifeLab Data Centre arrange an open SciLifeLab AI Seminar Series aimed at knowledge-sharing about Artificial Intelligence and applications in the Life Science community. The seminar series is open to everyone. The seminar is run over Zoom on the third Friday of the month during academic terms\, typically between 10 and 11 am\, with approx. 45 min presentation and 15 min discussion. \n\n\n\nAbstract \n\n\n\nUMAP is a golden standard dimensionality reduction method in single cell biology\, yet it has a controversial reputation and is sometimes heavily criticized\, see for example [1 – 5]. In particular\, the recent Nature publication of All of Us program [6] gave rise to an avalanche of discussions in scientific community regarding the controversial UMAP figure of human populations suggesting that UMAP is not accurate for this purpose. Remarkably\, the main criticism of UMAP originates (to the best of my knowledge) from the population genomics community\, wile the single cell community seems to be satisfied with the quality of UMAP analysis. \n\n\n\nIn this talk I will discuss peculiarities of data in single cell and population genomics analyses\, and explain some insights from the UMAP algorithm\, which could potentially attempt to resolve the contradiction between the two communities and very different research questions studied by the communities. I will also cover the foundations of PCA + tSNE + UMAP algorithms and emphasize their pros and cons for different types of data in Life Sciences. \n\n\n\n[1] https://simplystatistics.org/posts/2024-12-23-biologists-stop-including-umap-plots-in-your-papers/[2] https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011288[3] https://x.com/jkpritch/status/1759769445759893832?lang=en[4] https://www.nature.com/articles/d41586-024-00568-w[5] https://www.science.org/content/article/huge-genome-study-confronted-concerns-over-race-analysis[6] https://www.nature.com/articles/s41586-023-06957-x \n\n\n\nSlides \n\n\n\nDownload slides (PDF) URL:https://www.scilifelab.se/event/is-umap-accurate-addressing-some-fair-and-unfair-criticism/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250218T120000 DTEND;TZID=Europe/Stockholm:20250218T130000 DTSTAMP:20260408T005540 CREATED:20250207T145034Z LAST-MODIFIED:20250210T141259Z UID:10001478-1739880000-1739883600@www.scilifelab.se SUMMARY:Multimodal Imaging: Optimized Workflows for Improved Efficiency and Precision DESCRIPTION:This seminar talk is part of the SciLifeLab site Umeå/KBC Infrastructure Seminar series. The seminar series is held in Glasburen at KBC\, Umeå\, and online attendance is available via Zoom (link provided upon registering). \n\n\n\n\n\n\n\n\nPresenter: Cecilia Fager\, PhD\, Electron Microscopy Product and Application Specialist\, ZEISS NordicsAbstract: As the complexity of scientific questions increases\, approaches to address them are developed. One of the recent trends is the use of multimodal imaging where different microscopy techniques are used in combination to generate more detailed insights about a particular specimen. This seminar shows how multimodal imaging can be used to optimize the workflow for improved efficiency and precision. \n\n\n\nRead more and register\n\n\n\n\n\nSciLifeLab Site Umeå/KBC Infrastructure Seminar Series\n\n\n\nThis event is part of the SciLifeLab site Umeå/KBC Infrastructure Seminar series\, for future events in spring 2025\, check the seminar series home page \n\n\n\nTake me there URL:https://www.scilifelab.se/event/multimodal-imaging-optimized-workflows-for-improved-efficiency-and-precision/ LOCATION:Glasburen Seminar Room\, Chemical Biological Centre (KBC) Building\, Umeå University\, Umeå\, 901 87\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/05/SciLifeLab-Site-Umea-seminar-scaled.jpg ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250218T140000 DTEND;TZID=Europe/Stockholm:20250218T143000 DTSTAMP:20260408T005540 CREATED:20250210T114551Z LAST-MODIFIED:20250211T101325Z UID:10001483-1739887200-1739889000@www.scilifelab.se SUMMARY:CSI Seminar: Sleep Hygiene & Habits - invited talk by Ikaro Beraldo DESCRIPTION:Struggling with restless nights and low energy during the day? Sleep quality is influenced by daily habits\, not just the number of hours spent in bed. This seminar will explore the impact of routines\, environment\, and common misconceptions on sleep. Practical strategies will be discussed to improve rest\, boost focus\, and enhance overall well-being. Understanding sleep hygiene can lead to better mood\, productivity\, and long-term health. Small changes can make a big difference in achieving deeper\, more restorative sleep. \n\n\n\nWe will begin with a ~ 20 min talk\, held in Solna and over zoom. Then proceed with a reflection and discussion held only on-site. We encourage other sites to form watch parties\, by listening in together to the talk and then hold their own discussion afterwards. Hopefully seeding many local chapters of CSI. \n\n\n\nTo help facilitate discussion and reflection\, consider the following starter questions: \n\n\n\nAwareness: where do we experience sleep habits in our lives? \n\n\n\nAnalysis: how do I currently interact with sleep hygiene? \n\n\n\nAlternative: how could we relate to sleep habits\, in ourselves and others? \n\n\n\nAction: how will knowledge of sleep hygiene change my decisions going forward? URL:https://www.scilifelab.se/event/csi-seminar-sleep-hygiene-habits-invited-talk-by-ikaro-beraldo/ LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="Coaching in Science Initiative (CSI)":MAILTO:sami.saarenpaa@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250218T151500 DTEND;TZID=Europe/Stockholm:20250218T161500 DTSTAMP:20260408T005540 CREATED:20250206T124708Z LAST-MODIFIED:20250206T124825Z UID:10001479-1739891700-1739895300@www.scilifelab.se SUMMARY:In vivo site-specific engineering to reprogram human T cells DESCRIPTION:Spotlight seminar series welcomes the newly recruited SciLifeLab Fellow William Nyberg to present his research in Air&Fire Campus Solna on February 18th. \n\n\n\n\n\n\n\nWilliam Nyberg\, PhD\, is a newly appointed principal investigator at the Karolinska Institute. Building on scientific discoveries as a postdoc in Justin Eyquem’s research lab at UCSF\, his lab focuses on reprogramming T cells in vivo using advanced genetical engineering for therapeutic purposes. This is done primarily with the use of CARs\, but are also exploring the use of other synthetic receptors and therapeutic TCR sequences to develop new T cell therapies against cancers. In 2023\, he was honored with the Excellence in Research Award by the ASGCT and joined the Karolinska Institute and Science for Life Laboratory in 2024 to pursue his research. \n\n\n\nAbstract \n\n\n\nEngineered T cells\, reprogrammed to express chimeric antigen receptors (CAR) or T cell receptors (TCR)\, have transformed cancer treatment and are being explored as therapeutics for autoimmune disorders and infectious diseases. Enhancing T cell function through genome editing—either by disrupting endogenous genes or precisely inserting DNA payloads—has shown significant promise. However\, the ex vivo manufacturing process is lengthy\, costly\, and requires pre-conditioning\, limiting the accessibility of these therapies. In vivo generation of CAR-T cells could overcome these barriers. In this presentation\, I will demonstrate that stable and cell-specific transgene expression can be achieved through in vivo site-specific integration of large DNA payloads. We developed a two-vector system to deliver CRISPR-Cas9 ribonucleoproteins (RNPs) and a DNA donor template\, using enveloped delivery vehicles (EDVs) and adeno-associated virus (AAVs)\, respectively. By integrating a CAR transgene into a T cell-specific locus we generated therapeutic levels of CAR-T cells in a humanized mouse model in vivo. These findings offer a promising pathway to more efficient\, precise\, and widely accessible T cell therapies. URL:https://www.scilifelab.se/event/in-vivo-site-specific-engineering-to-reprogram-human-t-cells/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg ORGANIZER;CN="Spotlight Seminar Series":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250219T150000 DTEND;TZID=Europe/Stockholm:20250219T163000 DTSTAMP:20260408T005540 CREATED:20250205T115115Z LAST-MODIFIED:20250210T140957Z UID:10001476-1739977200-1739982600@www.scilifelab.se SUMMARY:PULSE Challenge: Properties and challenges with therapeutic oligonucleotides illustrated by hybridization-dependent off-target assessment DESCRIPTION:This presentation will describe this workflow and discuss considerations for various ONT classes\, emphasizing the importance of ONT-specific factors such as chemistry\, delivery systems\, and tissue distribution in OffT evaluation. It will also cover strategies for experimental verification and risk assessment and discuss the potential of machine learning models to enhance OffT prediction. \n\n\n\nThe seminar series PULSE Challenge is connected to the MSCA co-funded* postdoctoral program SciLifeLab PULSE\, that will train 48 future leaders in life sciences. The program focuses on innovative\, fundamental and translational research carried out in supportive and diverse academic and industrial environments\, preparing postdocs with necessary skills for long-term career sustainability. Click HERE to find out more about SciLifeLab PULSE \n\n\n\n\n\n\n\nOn-line event via Zoom \n\n\n\nRegister Here\n\n\n\n\n\n\n\n\n\n\n\n\n\nPresenter: Dr Patrik Andersson\, PhDSenior Director\, RNA Therapeutics SafetyAstraZeneca\, Gothenburg\, Sweden \n\n\n\nAbstract:Hybridization-dependent off-target (OffT) effects\, occurring when oligonucleotides bind via Watson-Crick-Franklin hybridization to unintended RNA transcripts\, remain a critical safety concern for therapeutic oligonucleotides (ONTs). Despite the importance of OffT assessment of clinical trial ONT candidates\, formal guidelines were for many years lacking\, with only brief mentions in Japanese regulatory documents (2020) and FDA recommendations for HBV (hepatitis B virus) treatments (2022). A subcommittee of the Oligonucleotide Safety Working Group (OSWG)\, was formed to gather experiences and develop updated industry recommendations for assessing OffTs of ONTs. The proposed workflow encompasses five key steps: 1) OffT identification through in silico complementarity prediction and transcriptomics analysis\, 2) focus on cell types with relevant ONT activity\, 3) in vitro verification and margin assessment\, 4) risk assessment based on the OffT biological role\, and 5) management of unavoidable OffTs. \n\n\n\nThis presentation will describe this workflow and discuss considerations for various ONT classes\, emphasizing the importance of ONT-specific factors such as chemistry\, delivery systems\, and tissue distribution in OffT evaluation. It will also cover strategies for experimental verification and risk assessment and discuss the potential of machine learning models to enhance OffT prediction. \n\n\n\nBiography:Patrik joined AstraZeneca in Gothenburg\, Sweden 2004 as “Discovery Toxicologist”\, leading the safety work from target identification to candidate selection for numerous projects. From 2012\, he developed into an expert in the safety of nucleotide-based drugs and their delivery. This includes leading the non-clinical safety work internally at AstraZeneca and in collaborations with world leading companies in the fields of antisense oligonucleotides and therapeutic mRNA. Author of several peer reviewed primary and review papers and book chapters in the area of preclinical safety assessment of oligonucleotide therapeutics and active member in several cross-industry collaboration groups. Most recently active member of the EFPIA/PDEG and IQ/DruSafe oligo working groups and leading the OSWG subcommittee that resulted in a recently accepted paper on revised industry recommendations for off-target safety assessment (DOI: 10.1089/nat.2024.0072) URL:https://www.scilifelab.se/event/pulse-challenge-properties-and-challenges-with-therapeutic-oligonucleotides-illustrated-by-hybridization-dependent-off-target-assessment/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/02/Bild1-e1770905208628.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250219T151500 DTEND;TZID=Europe/Stockholm:20250219T161500 DTSTAMP:20260408T005540 CREATED:20250210T171944Z LAST-MODIFIED:20250211T101304Z UID:10001484-1739978100-1739981700@www.scilifelab.se SUMMARY:[The Svedberg seminar]-Imaging the molecular processes of cell division across scale DESCRIPTION:Jan EllenbergProfessor Karolinska Institutet Stockholm\, Sweden and European Molecular Biology Laboratory\, Heidelberg\, Germany Director\, Science for Life Laboratory\, Sweden \n\n\n\n \n\n\n\nTHE LENNART PHILIPSON MEMORIAL LECTURE2025 \n\n\n\nLecture hall A1:107a\, BMC\, Uppsala University Wednesday\, February 19\, 2025 at 3:15 pm   \n\n\n\nBio \n\n\n\nProf. Jan Ellenberg Professor Ellenberg is renowned for his groundbreaking research in cell biology\, particularly in the areas of advanced imaging and the study of cell division. His approach of the so-called 4D dynamic change of molecular structures in living cells\, studied in individual\, and all the way into cells\, embedded in organismal tissues has generated new insight and opened immense technological potential. Dr. Ellenberg has been a group leader at the European Molecular Biology Laboratory (EMBL) since 1999\, the head of the Gene Expression Unit between 2006-2010 and the head of the Cell Biology and Biophysics Unit since 2010. He has been coordinating infrastructure development within EMBL and at the European level. Since July 2024\, Dr. Ellenberg has been acting as the Director of SciLifeLab in Sweden\, became Professor at Karolinska Institutet and an Affiliated Professor at Stockholm University and KTH Royal Institute of Technology. A single (!) representative publication out of the long series of top articles published by Ellenberg and his group highlights the essence of this year’s Lennart Philipson Memorial lecture: Gerlich D\, Ellenberg J. 4D imaging to assay complex dynamics in live specimens. Nat Cell Biol. 2003; Suppl: S14-9. Welcome! URL:https://www.scilifelab.se/event/the-svedberg-seminar-jan-ellenberg/ LOCATION:BMC Lecture hall A1:107a\, BMC\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250220T120000 DTEND;TZID=Europe/Stockholm:20250220T130000 DTSTAMP:20260408T005540 CREATED:20250109T101214Z LAST-MODIFIED:20250307T105611Z UID:10001433-1740052800-1740056400@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Xue Zhang & Elisabeth Söderberg DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nXue Zhang\n\n\n\nBennie Lemmens – alpha 5 \n\n\n\nNanoscale view on genome instability \n\n\n\n\n\nElisabeth Söderberg\n\n\n\nPer-olof Syren – gamma 5 \n\n\n\nEnzyme catalysis as a tool in monomer synthesis \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-xue-zhang-elisabeth-soderberg/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/12/IMG_4110-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250221T100000 DTEND;TZID=Europe/Stockholm:20250221T110000 DTSTAMP:20260408T005540 CREATED:20250212T122415Z LAST-MODIFIED:20250212T122416Z UID:10001486-1740132000-1740135600@www.scilifelab.se SUMMARY:Policing secretion: cargo capture into ER-derived vesicles initiates secretion DESCRIPTION:Visiting Professor Liz Miller from the Division of Molecular\, Cell and Developmental Biology\, School of Life Sciences\, University of Dundee\, Scotland UK\, will give a seminar at SciLifeLab Campus Solna. The seminar should be of particular interest to cell and structural biologists interested in membrane associated processes operating during the early stages of the secretory pathway. \n\n\n\nBackground\n\n\n\nOne third of the proteins encoded in eukaryotic genomes pass through the secretory pathway\, entering via the endoplasmic reticulum (ER). The Miller lab has made pivotal contributions\, dissecting the molecular mechanisms operating during the early stages of ER-associated secretory protein biogenesis. Specifically\, the research has focused on understanding protein quality control and export from the ER. The lab has exploited the budding yeast\, Saccharomyces cerevisiae\, as a model system\, taking advantage of the full spectrum of biochemical\, genetic\, genomic and proteomic tools\, including cryo-EM. The research has defined mechanisms relevant to a number of human diseases\, most notably cystic fibrosis and similar diseases of protein misfolding. Recently\, the Miller lab has been examining how secretory cargo is selected for ER export in human cells\, which will be the focus of her talk here at SciLifeLab Campus Solna. \n\n\n\nBiography\n\n\n\nProfessor Liz Miller carried out her PhD in Melbourne\, Australia\, working on intracellular traffic of plant defence proteins. In 1999\, as a Jane Coffin Childs Postdoctoral Fellow\, she joined Randy Schekman’s lab (note: prior to his Nobel Prize awarded in 2013) at the University of California\, Berkeley. In the Schekman lab\, Liz established the mechanistic basis for capture of nascent secretory proteins into ER-derived COPII vesicles. In 2005 Liz established her independent lab at Columbia University in New York\, and after 10 years moved to become a Programme Leader/MRC Investigator at the MRC Laboratory of Molecular Biology in Cambridge\, where she maintains a small lab. In 2023\, Liz joined the Division of Molecular\, Cell and Developmental Biology within the School of Life Sciences in 2023. \n\n\n\nRead more\nhttps://www.dundee.ac.uk/people/liz-miller \n\n\n\n\nLiz Miller\n\n\n\n\n\n\n\n\n\nHost: Per Ljungdahl\, per.ljungdahl@scilifelab.se URL:https://www.scilifelab.se/event/policing-secretion-cargo-capture-into-er-derived-vesicles-initiates-secretion/ LOCATION:Gamma 7 Lunchroom\, Tomtebodavägen 23A\, Solna\, 17121 CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250225T120000 DTEND;TZID=Europe/Stockholm:20250225T130000 DTSTAMP:20260408T005540 CREATED:20250206T095146Z LAST-MODIFIED:20250210T141359Z UID:10001477-1740484800-1740488400@www.scilifelab.se SUMMARY:PULSE Challenge: ML/AI approaches for designing proximity-inducing small molecules  – PROTAC cell permeability and bioavailability DESCRIPTION:The seminar series PULSE Challenge is connected to the MSCA co-funded* postdoctoral program SciLifeLab PULSE\, that will train 48 future leaders in life sciences. The program focuses on innovative\, fundamental and translational research carried out in supportive and diverse academic and industrial environments\, preparing postdocs with necessary skills for long-term career sustainability. Click HERE to find out more about SciLifeLab PULSE \n\n\n\n\n\n\n\nOn-line event via Zoom \n\n\n\nRegister Here\n\n\n\n\n\n\n\n\n\n\n\n\n\nPresenters: Prof. Jan Kihlberg & Assoc. prof. Vasanthanathan PoongavanamUppsala University\, Sweden \n\n\n\nAbstract:Most PROTACs which have a “druglike” oral bioavailability (>5%) are based on a CRBN E3-ligase ligand\, but a few VHL PROTACs also display >5% bioavailability. Use of 2D descriptors places oral drugs\, CRBN and VHL PROTACs in different parts of chemical space\, while the use of 3D descriptors indicates that the chemical spaces overlap. Use of 3D descriptors may therefore enhance the probability of discovering PROTACs with satisfactory oral bioavailability \n\n\n\nWe have studied CRBN and VHL PROTACs by NMR spectroscopy and MD simulations. These studies revealed that the propensity of the PROTACs to adopt folded and semi-folded conformations with low solvent – accessible 3D polar surface area correlated to higher cell permeability. The length\, chemical nature and flexibility of the linker was found to be essential for allowing intramolecular hydrogen bonds\, π–π interactions and van der Waals interactions to stabilize (semi)folded conformations for permeable PROTACs in a membrane-like environment. \n\n\n\nUse of MD simulations for prediction of the conformations and properties of PROTACs is time consuming. However\, classification models that were developed by machine learning using 2D descriptors allowed differentiation between VHL PROTACs that had high or low cell permeability. Such models can be integrated as effective filters to prioritize PROTACs for synthesis in the design process. Nevertheless\, certain challenges remain\, including the imbalanced nature of datasets\, and model interpretability. Addressing these limitations in future studies will be crucial for maximizing the full potential of machine learning in PROTAC design. \n\n\n\nBiographies:Jan Kihlberg holds a chair in Organic Chemistry at Uppsala University\, Sweden since 2013. His key research interests are to understand what properties convey cell permeability\, aqueous solubility and target binding to drugs such as PROTACs and macrocycles in the beyond rule of 5 space and to translate this knowledge into guidelines for design. He has published more than 200 peer–reviewed publications and book chapters. He establishing his independent research group at Lund University in 1991\, became full professor in Bioorganic Chemistry at Umeå University in 1996\, then moved to AstraZeneca R&D in Gothenburg in 2003 while maintaining a research group at Umeå University. At AstraZeneca Prof. Kihlberg held the role as Director\, Head of Medicinal Chemistry for seven years. \n\n\n\nVasanthanathan Poongavanam is a computational chemistry and AI expert at the DDD Platform\, SciLifeLab\, Uppsala University\, Sweden. His research focuses on applying computational chemistry and AI methodologies to accelerate drug discovery projects. He has authored more than 60 scientific publications\, including research articles\, reviews\, and book chapters. URL:https://www.scilifelab.se/event/pulse-challenge-ml-ai-approaches-for-designing-proximity-inducing-small-molecules-protac-cell-permeability-and-bioavailability/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/02/Bild1-e1770905208628.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250226T150000 DTEND;TZID=Europe/Stockholm:20250226T160000 DTSTAMP:20260408T005540 CREATED:20250212T121850Z LAST-MODIFIED:20250212T123251Z UID:10001485-1740582000-1740585600@www.scilifelab.se SUMMARY:SciLifeLab Lund Seminar Series | DST DESCRIPTION:Welcome to the SciLifeLab Lund seminar series! \n\n\n\nThese seminars are designed to highlight SciLifeLab Lund\, our cutting-edge research infrastructure\, and the diverse resources available to the scientific community. \n\n\n\nIn the 5th seminar\, we will have a look into the Display & Selection Technologies unit (DST) which is part of the SciLifeLab Drug Discovery & Development platform. The DST unit supports the development of therapeutic antibodies and single domain antibodies. \n\n\n\nMikael Mattsson (DST’s Head of Unit) will present the unit\, and Carl Sandén (Division of Clinical Genetics at Lund University) will will showcase a project carried out in collaboration with the facility. \n\n\n\nPlease note that the seminars are site only but the recordings are available HERE. \n\n\n\nRegistration\n\n\n\nRegister for the next seminars!\n\n\n\n26th March 2025 | Lund University Bioimaging Centre (LBIC)  \n\n\n\nRegister Seminar March\n\n\n\n23rd April 2025 | Lund Protein Production Platform \n\n\n\nRegister Seminar April\n\n\n\n28th May 2025 | National Bioinformatics Infrastructure (NBIS) \n\n\n\nRegister Seminar May\n\n\n\n18th June | Structural Proteomics \n\n\n\nRegister Seminar June URL:https://www.scilifelab.se/event/scilifelab-lund-seminar-series-dst/ LOCATION:Belfragesalen\, BMC D15\, Klinikgatan 32\, Lund\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Lund":MAILTO:lund@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250227T120000 DTEND;TZID=Europe/Stockholm:20250227T130000 DTSTAMP:20260408T005540 CREATED:20250109T101605Z LAST-MODIFIED:20250307T105827Z UID:10001434-1740657600-1740661200@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Osheen Sharma & Solenne Bleuse DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nOsheen Sharma\n\n\n\nBrinton Seashore-Ludlow – alpha 4 \n\n\n\nEvaluating Feature Extraction in Ovarian Cancer Cell Line Co-Cultures Using Deep Neural Networks \n\n\n\n\n\nSolenne Bleuse\n\n\n\nOla Larsson – gamma 5 \n\n\n\nStiffness dependent translation in cancer \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-osheen-sharma-solenne-bleuse/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_120135408_HDR-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250305T110000 DTEND;TZID=Europe/Stockholm:20250305T150000 DTSTAMP:20260408T005540 CREATED:20250213T114127Z LAST-MODIFIED:20250213T114127Z UID:10001488-1741172400-1741186800@www.scilifelab.se SUMMARY:CBGE & DDD Roadshow in Lund | From Decoding Biology to Drug Discovery DESCRIPTION:SciLifeLab Lund is pleased to welcome SciLifeLab Chemical Biology & Genome Engineering Platform (CBGE) and Drug Discovery and Development Platform (DDD) and host their Roadshow in Lund. \n\n\n\nDuring the seminar “Small Molecules\, CRISPR & Chemical Proteomics: From Decoding Biology to Drug Discovery”\, we will have a look into both platforms and an user will showcase a project carried out in collaboration with them. The Seminar will be followed by a light lunch and individual consultation meetings. \n\n\n\nRegister here!\n\n\n\nIn this seminar:\n\n\n\nThe SciLifeLab Chemical Biology & Genome Engineering Platform \n\n\n\n\n            Anna-Lena Gustavsson\, Platform director\, KI\n\n\n\n            Fredrik Ek\, Chemical Biology Consortium Sweden\, LU\n\n\n\n            Bernhard Schmierer\, CRISPR Functional Genomics\, KI\n\n\n\n            Massimiliano Gaetani  Chemical Proteomics\, KI\n\n\n\n\nThe SciLifeLab Drug Discovery and Development Platform \n\n\n\n\n            Per Arvidsson\, Platform director\, KI\n\n\n\n\nUser presentation \n\n\n\n\nFunctional chemical reprogramming of cancer cells to induce antitumor immunity. Fábio Fiúza Rosa. Co-founder and Head of Research\, Asgard Therapeutics AB\, prev.  Filipe Pereira research group LU. URL:https://www.scilifelab.se/event/cbge-ddd-roadshow-in-lund-from-decoding-biology-to-drug-discovery/ LOCATION:Belfragesalen\, BMC D15\, Klinikgatan 32\, Lund\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Lund":MAILTO:lund@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250306T100000 DTEND;TZID=Europe/Stockholm:20250306T160000 DTSTAMP:20260408T005540 CREATED:20250114T125459Z LAST-MODIFIED:20250304T151829Z UID:10001453-1741255200-1741276800@www.scilifelab.se SUMMARY:Automation of research processes with LLMs and AI DESCRIPTION:SciLifeLab is thrilled to invite you to the symposium ‘Automation of research processes with LLMs and AI’\, to be held on March 6 at Eva & Georg Klein lecture hall\, Biomedicum\, Karolinska Institutet Campus Solna. \n\n\n\nThe purpose of the symposium is practical knowledge sharing\, inspiration\, and reflection on the future of scientific processes in life sciences and health research. Academic\, healthcare\, and industry researchers working within the broad life sciences are welcome to attend. \n\n\n\nMore and more AI-based tools are currently being integrated in scientific research processes\, from simple academic text editing tools to automated labs empowered by large language models (LLMs) running experiments and making scientific conclusions. For researchers in life sciences and health\, developments in the AI technologies are important because of the high potential\, large monetary investments\, but also expectations about future breakthroughs.This one-day event offers an opportunity for the researchers to hear about specific examples of incorporating Large Language Models (LLMs) and other recent developments in foundational AI models in research workflows as well as to discuss the future of scientific research processes with this new technology present. \n\n\n\nWe will start the morning with inspirational talks about new advances in research workflow automation. During lunch\, there will be a possibility to network and discuss different perspectives with other attendees. After lunch we plan to have interactive sessions where the audience will have an opportunity to share and discuss visions and expectations\, including spontaneous flash/pop-up talks by the attendees. \n\n\n\nThe talks will be livestreamed through Zoom. The rest of the event is on-site in Biomedicum only. \n\n\n\nRegistration\n\n\n\nRegistration \n\n\n\nParticipation is free of charge on the first-come first-served basis. Refreshments and lunch will be served for the on-site participants. Unfortunately\, we cannot accommodate allergies or dietary preferences for those who register after March 1. If you register to listen to livestreamed talks on Zoom\, you will receive a link on the day of the event. The talks will not be recorded and saved\, only streamed live on the day. \n\n\n\nRegister to attend\n\n\n\nWaiting List \n\n\n\nTo avoid empty seats\, registration will remain open until the event begins. If we reach full capacity\, a waiting list will be activated. Sign up for the waiting list\, and you will automatically receive an email when a spot becomes available. You must accept to secure the spot. If you decline\, the offer will go to the next person on the waiting list. \n\n\n\nCancellation \n\n\n\nTo minimize empty seats and especially food waste\, you must cancel your registration if you are unable to attend the event. If a waiting list is activated\, your spot will go to someone else. Otherwise\, your cancellation will result in us covering the cost of your refreshments and lunch. \n\n\n\nIf you have questions\, please contact datacentre@scilifelab.se \n\n\n\n\n\n\n\n\n\n\n\nSpeakers\n\n\n\nOlli Kallioniemi (KI/FIMM) – AI-Empowered Life Science: How Can You Benefit Today and in the Future?\nNobel prizes\, huge tech investments\, generative AI and AI agents\, multidisciplinary expertise\, expectations on emerging superhuman intelligence\, and 1\,000+ AI-powered approved medical devices all highlight AI’s transformative potential for life scientists. Yet\, many researchers remain unaware or skeptical\, often due to limited exposure. This talk will cover AI’s current and future impact in life sciences\, highlighting how it can empower every scientist\, boost research productivity\, and foster innovative approaches. \n\n\n\nOlli Kallioniemi is the Founding Director of the SciLifeLab & Wallenberg Data-Driven Life Science (DDLS) Program and served as Director of SciLifeLab from 2015 to 2024. He is a Professor of Molecular Precision Medicine at Karolinska Institute (OnkPat) and holds a joint appointment at the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki. He has recently focused on exploring and explaining the opportunities that AI offers for life science research and how AI can benefit every researcher. \n\n\n\n\nMelissa Harrison (EMBL-EBI) – How Europe PMC uses and supports LLM development for research workflows\nEurope PubMed Central (Europe PMC)\, developed by EMBL-EBI\, is a free\, open-access literature database containing over 45 million life science literature outputs; over 10 million of which are full text. This includes almost a million preprints from 34 different servers. Associated research outputs\, such as data\, are linked to the literature\, which is also enriched with additional persistent identifiers\, text mined funding information\, and text mined annotations of the articles and supplementary files. Annotations are dictionary-based and are being transitioned to a machine learning approach. This talk will discuss the potential of this transition and will explore how Europe PMC plans to leverage machine learning in the future while maintaining the community’s trust in its curated\, open dataset as a reliable resource for scientific research. Words of caution about AI and ghost workers\, including biocurators\, will also be mentioned. \n\n\n\nMelissa Harrison is the Lead of Literature Services at EMBL’s European Bioinformatics Institute (EMBL-EBI). After completing a biology degree at King’s College London she worked in scientific publishing for two decades. In her previous role at eLife she honed her skills in open science policy and implementation and has been instrumental in the propagation of open persistent identifiers and metadata. \n\n\n\n\n Aasa Feragen (DTU) – AI fairness — it doesn’t have to be hard\nAasa Feragen is a Professor in Medical Image Analysis at the Technical University of Denmark (DTU). \n\n\n\n\nMartin Eklund (KI) – Limitations of foundation models for achieving optimal performance\nFoundation models are undoubtedly highly useful. But are they a panacea for advancing performance of deep learning systems? If not\, what are their limitations? In the presentation\, we explore these questions using large and rich digitized prostate pathology data as an example. \n\n\n\nMartin Eklund is professor of epidemiology at the Department of Medical Epidemiology and Biostatistics where he focusses his research on reducing the mortality of prostate cancer as well as the negative side effects of today’s imprecise diagnostics and treatment selection. He works a lot on development of AI systems for clinical decision making. \n\n\n\n\nPrashant Singh (UU) – AI and Optimization for Science: Principles and Pitfalls\nData-driven science has emerged as a modern pillar of science\, complementing theory\, experiments and computational approaches. Scientific workflows – from design of experiments to data analysis\, have greatly benefited from tools and techniques from various fields including optimization\, statistics\, computational science\, etc. In this talk\, we will motivate principled approaches for various stages of the scientific research pipeline\, from traditional foundations such as optimization\, to recent AI-based advances such as large-language models. \n\n\n\nPrashant is an Assistant Professor\, and a SciLifeLab fellow hosted at the Department of Information Technology\, Science for Life Laboratory\, Uppsala University. His research interests involve developing machine learning and optimization methods to enable fast\, data-efficient analysis and processing of scientific data\, particularly in the domain of life sciences. \n\n\n\n\nPhil Ewels (Seqera) – Building and testing scientific workflows with LLMs and AI agents\nNextflow has become the leading tool for scientific workflows in bioinformatics\, but writing workflows can be challenging. This talk introduces Seqera AI\, a new tool that helps generate Nextflow pipelines either from scratch\, from existing scripts\, or even other workflow languages. I’ll discuss how Seqera AI is able to generate best-practice DSL2 code that follows nf-core guidelines\, and how we go beyond just code generation: creating and running test suites with AI agents\, streamlining development while improving code quality and validation. \n\n\n\nPhil Ewels is Senior Product Manager for Open Source at Seqera\, working with Nextflow\, MultiQC\, nf-core and Wave. Before joining Seqera in 2022\, Phil worked at the National Genomics Infrastructure (NGI) at SciLifeLab in Stockholm\, Sweden. It was through this work that Phil became involved with Nextflow and eventually co-founded the nf-core community. Phil’s career has spanned many disciplines from lab work and bioinformatics research in epigenetics\, through to software development and community engagement. He is the author of MultiQC\, SRA-Explorer\, QCFail.com\, and has a PhD in Molecular Biology from the University of Cambridge\, UK. \n\n\n\n\nProgram\n\n\n\nAutomation_of_research_workflows_March_6_programmeDownload URL:https://www.scilifelab.se/event/automation/ LOCATION:Eva & Georg Klein lecture hall\, Biomedicum\, Solnavägen 9\, 171 65 Solna\, Solna\, 171 65\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/01/circos_cropped.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250306T120000 DTEND;TZID=Europe/Stockholm:20250306T130000 DTSTAMP:20260408T005540 CREATED:20250109T101735Z LAST-MODIFIED:20250303T105639Z UID:10001435-1741262400-1741266000@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Sarah Narrowe Danielsson & Taobo Hu DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nSarah Narrowe Danielsson\n\n\n\nArne Elofsson – alpha 6 \n\n\n\nPredicting protein-protein interactions using machine learning \n\n\n\n\n\nTaobo Hu\n\n\n\nMats Nilsson – gamma 4 \n\n\n\nSingle-Cell Spatial Transcriptomics Reveals Molecular Correlation with Morphological Invasiveness in Noguchi Type C Lung Adenocarcinoma \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-sarah-narrowe-danielsson-taobo-hu/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_123412496_HDR2-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250307T140000 DTEND;TZID=Europe/Stockholm:20250307T150000 DTSTAMP:20260408T005540 CREATED:20250228T141333Z LAST-MODIFIED:20250304T084852Z UID:10001500-1741356000-1741359600@www.scilifelab.se SUMMARY:Ultrasensitive variant detection with ddPCR and sRCA DESCRIPTION:Clinical Genomics Webinar Series\n\n\n\nClinical Genomics Uppsala is hosting this webinar as part of the webinar series by the Clinical Genomics Platform \n\n\n\n \n\n\n\njoin zoom webinar\n\n\n\nThe webinar will focus on Rare tumor-specific mutations are valuable markers for tracking disease progression and therapy responses. As disease relapse remains a major challenge in Myelodysplastic Syndrome\, the need for ultrasensitive assay techniques for detecting these very low frequency mutations are needed to detect relapse at the earliest time possible. \n\n\n\nIn Clinical Genomics Uppsala we explore superRCA assays—an advanced\, highly sensitive\, and cost-effective amplification technology\, in a retrospective study in patients with MDS\, monitoring the pre-identified patients mutations after hematopoietic stem-cell transplantation. This method has shown a very high sensitivity\, enables detection of DNA variants at very low frequencies using standard flow cytometry\, and the results and performance was compared with the results of ddPCR\, commonly used method in the clinic. \n\n\n\nEveryone is welcome so feel free to spread the details with anyone who may be interested. Hope to see you there! \n\n\n\nHost: Malin Melin\, co-PD \n\n\n\nInvited speakers: Lei Chen\, Rarity Bioscience and Sara Löfgren\, Clinical Genomics Uppsala URL:https://www.scilifelab.se/event/clinical-genomics-webinar-series-ultrasensitive-variant-detection-with-ddpcr-and-srca/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/11/CG-webinar-series_crop.png ORGANIZER;CN="Clinical Genomics Uppsala":MAILTO:clinicalgenomicsuppsala@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250310T080000 DTEND;TZID=Europe/Stockholm:20250314T170000 DTSTAMP:20260408T005540 CREATED:20241212T094918Z LAST-MODIFIED:20250207T090557Z UID:10001416-1741593600-1741971600@www.scilifelab.se SUMMARY:Workshop for Cryo-electron Tomography DESCRIPTION:Location: UCEM facility (EM-building) and Chemical Biological Centre (KBC) building\, Umeå University\, Linnaeus väg 6\, Umeå \n\n\n\nDeadline for registration: 13 January 2025 \n\n\n\nCryo-electron tomography (cryo-ET) is a powerful structural technique. Its power comes from its versatility to study biological systems in vitro or in situ\, i.e. within cells or tissue. It has the ability to reach uncharted regions in biological systems at high resolution. Advancements in microscopes\, cameras\, and computation make it now possible to determine sub-10 Å 3-dimensional structures of molecules directly within cells. \n\n\n\nThis four-and-a-half-day workshop will cover cryo-ET workflows from sample preparation on EM grids to data processing and analysis. The workshop will be a mixture of lectures and practical sessions. Participants will get hands-on experience in sample preparation on EM grids (micropatterning)\, sample freezing (plunge freezing and high-pressure freezing)\, cryo-correlative light and electron microscopy (cryo-CLEM)\, cryo-focused ion beam milling (cryo-FIB)\, cryo-TEM tiltseries data collection\, and data processing and analysis (MotionCor2\, IMOD\, Dynamo). \n\n\n\nIt is compulsory that applicants have previous cryo-EM experience either with single-particle or already with cryo-tomography. \n\n\n\nThis workshop is supported by SciLifeLab\, CryoNET and Umeå University and organized by the Umeå Centre for Electron Microscopy (UCEM). \n\n\n\nContact email: erin.schexnaydre@umu.se URL:https://www.scilifelab.se/event/workshop-for-cryo-electron-tomography/ LOCATION:KBC Building Umeå\, Linneaus Väg 6\, Umeå CATEGORIES:Course ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2020/11/CryoEM.jpg ORGANIZER;CN="UCEM Ume%C3%A5":MAILTO:hussein.haggag@umu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250310T151500 DTEND;TZID=Europe/Stockholm:20250310T161500 DTSTAMP:20260408T005540 CREATED:20250123T150313Z LAST-MODIFIED:20250210T141539Z UID:10001461-1741619700-1741623300@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Human beta cell protection by Nature DESCRIPTION:Bart RoepProfessorLeiden University Medical Center\, Netherlands \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nBart Roep is Professor of Medicine & Professor of Diabetology\, Immunopathology and Intervention at the Department of Internal Medicine\, Leiden University Medical Center\, Leiden\, Netherlands\, where he heads the Section Immuno-modulation & Regenerative Medicine. He studied Medicine and Life Sciences at the University of Amsterdam and obtained his PhD in Medicine at Leiden University. He pioneered studies on the role of T-cells in the pathogenesis of T1D and discovered some of their targets in β-cells\, provided seminal proof of their role in human β-cell destruction and defined immune correlates of disease progression and therapeutic intervention. He contributed to a suite of clinical intervention trials in T1D\, including pioneering strategies on tissue-specific tolerance induction\, regenerative medicine\, gene and stem cell therapy\, faecal microbiome transplantation and β-cell replacement therapies (pancreatic donor islets and embryonic stem cell derived β-cell progenitors). A profound twist in prevalent belief of the immunopathogenesis involved his discovery of the role of β-cells in their own demise. His current focus is on regenerative medicine in T1D from an immunological perspective. \n\n\n\nHuman beta cell protection by Nature\n\n\n\nType 1 diabetes results from an autoimmune mediated destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans in people with genetic predisposition to develop this disease. Insulin gene (INS) variation and beta-cell stress associate with risk for development of type 1 diabetes  (T1D) and autoimmunity against insulin. We discovered the relationship between ER stress and insulin mRNA from INS risk variants in human β-cells\, and how this variation relates to β-cells function\, stress and immunogenicity. This novel explanation for genetic protection from T1D inferred by INS polymorphism\, puts β-cells in the center of T1D pathogenesis. Beta cells carrying this particular protective INSP variant can alleviate ER stress by insulin mRNA decay\, resulting in reduced immunogenicity and improved islet function. We propose that INSP is a causal variant contributing to genetic protection from T1D. The clinical and therapeutic implications of this discovery will be discussed. \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nHost: Olov Andersson olov.andersson@mcb.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-bart-roep/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250311T090000 DTEND;TZID=Europe/Stockholm:20250313T150000 DTSTAMP:20260408T005540 CREATED:20250225T143452Z LAST-MODIFIED:20250225T143454Z UID:10001498-1741683600-1741878000@www.scilifelab.se SUMMARY:Exhibition in Navet at BMC\, Uppsala University DESCRIPTION:On March 11-13\, between 09.00-15.00\, you have a new opportunity to visit our exhibition in Navet at BMC. This is a chance to receive information and updates from 30 of the leading life science companies in Sweden. The entrance to Navet will be open between 09:00-15:00 for external visitors. URL:https://www.scilifelab.se/event/exhibition-in-navet-at-bmc-uppsala-university/ LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/02/Webb-bild_Mar-11-13_2025.png ORGANIZER;CN="SciLifeLab Navet":MAILTO:lokalbokning@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250311T100000 DTEND;TZID=Europe/Stockholm:20250311T110000 DTSTAMP:20260408T005540 CREATED:20250205T093234Z LAST-MODIFIED:20251125T145447Z UID:10001473-1741687200-1741690800@www.scilifelab.se SUMMARY:The Nagoya Protocol in Action: Practical Steps for Compliance and Benefit-Sharing DESCRIPTION:This presentation will focus on how to handle the Nagoya Protocol in practice. Whether you’re new to it or already have some experience\, you’ll get clear guidance on how to stay compliant\, draft agreements\, and navigate access and benefit-sharing rules. We’ll go through practical steps\, common challenges\, and what to aim for when working with genetic resources. The goal is to make the process more manageable and help you confidently meet legal requirements while building fair collaborations. \n\n\n\nConducting research using genetic resources? Collecting biological material?The Nagoya Protocol establishes a framework that helps researchers access genetic resources for research & development in return for a fair share of any benefits from their use. Curious about the rules for the use of genetic resources? In this seminar\, Sebastian Bromander from SLU – Sveriges Lantbruksuniversitet will explain how to handle the Nagoya Protocol in practice! \n\n\n\nPresenter: Sebastian BromanderSwedish University of Agricultural Sciences (SLU) \n\n\n\nLink to the recording on YouTube. \n\n\n\nLink to the presentation slides. \n\n\n\nMore info\nThis event is part of the SciLifeLab Data Management seminar series\, an event series by the SciLifeLab Data Centre and NBIS joint Data Management team. \n\n\n\nThe goal of the events in this seminar series is to provide interesting interactive seminars around topics related to Research Data Management and Open Science in general\, and to foster discussions around best practices. \n\n\n\nThe events are open to everyone working at or affiliated with a Swedish research institute or university. We welcome all researchers\, educational professionals\, staff\, RDM professionals\, and others with an interest in life sciences\, from all university levels. The events are informal and inclusive\, so feel welcome to join and participate in our interesting discussions! \n\n\n\nThe events will be recorded and published openly after the seminars on the SciLifeLab YouTube channel. \n\n\n\nLink to the recording on YouTube. \n\n\n\nLink to the presentation slides will follow soon.More information about SciLifeLab Data Centre and NBIS joint Data Management seminar series: https://www.scilifelab.se/data/scilifelab-data-management-seminar-series/ \n\n\n\nFor more information or inquiries\, please contact: data-management@scilifelab.se URL:https://www.scilifelab.se/event/datamanagement-nagoya-protocol/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/02/DC_seminar-series_background1-1.png ORGANIZER;CN="Open Science Seminar Series":MAILTO:data-management@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250313T120000 DTEND;TZID=Europe/Stockholm:20250313T130000 DTSTAMP:20260408T005540 CREATED:20250109T101849Z LAST-MODIFIED:20250307T105945Z UID:10001436-1741867200-1741870800@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Anna Mäkiniemi & Emma Latron DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nAnna Mäkiniemi\n\n\n\nEmma Lundberg – alpha 2 \n\n\n\n \n\n\n\n\n\nEmma Latron\n\n\n\nJuliette Griffié – gamma 6 \n\n\n\nInvestigating MS through the characterization of B cells molecular landscape with microscopy \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-anna-makiniemi-emma-latron/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_124630107_HDR-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250317T120000 DTEND;TZID=Europe/Stockholm:20250318T150000 DTSTAMP:20260408T005540 CREATED:20241204T083941Z LAST-MODIFIED:20250312T072352Z UID:10001415-1742212800-1742310000@www.scilifelab.se SUMMARY:Imaging in Cell and Molecular Biology DESCRIPTION:The DDLS research area symposia series aims to engage and build a strong national scientific community around the DDLS research themes. Each of the four areas arranges two symposia per year. Everyone interested in data-driven research is welcome to take part. We want to bring together researchers\, industry\, and healthcare to foster collaboration and push the frontiers of data-driven life science. \n\n\n\nThe DDLS research area Expert Group in Cell and Molecular Biology invites all interested in Data-driven life science to meet\, present\, interact\, and discuss Imaging in Cell and Molecular Biology. \n\n\n\nThe event will take place at Ångström Laboratory in Uppsala and will include presentations from international and national invited speakers and selected abstracts. The event is free of charge. \n\n\n\nDate: March 17 – 18\, 2025 \n\n\n\nStart: at 12:00 on March 17\, with lunch and registration. \n\n\n\nEnd: with lunch 12:20-13:15 on March 18. \n\n\n\nVenue: Room Heinz-Otto Kreiss\, Ångström Laboratory\, Lägerhyddsvägen 1\, 752 37 Uppsala. Find your way – Maze map link here! \n\n\n\nFind your way: From Uppsala Central Station\, take buss № 4 (place B4) to Polacksbacken (find timetables for Uppsala City buses here). \n\n\n\nPoster session\n\n\n\nThe poster session starts at 17:10 with networking and refreshments. Find the poster list and abstracts below. \n\n\n\nFor accepted Posters\, if you have registered for: \n\n\n\n\nPaper/canvas poster: Hang your poster during the coffee break in Room 101136 (Evelyn Sokolowski). \n\n\n\nDigital poster: Display your presentation in Room 101142 (next to Evelyn Sokolowski).\n\n\n\n\nPins will be available\, and the poster boards will be marked with poster numbers. \n\n\n\nList Posters Abstract v6Download\n\n\n\nCompany Exhibition\n\n\n\nYou will have the opportunity to meet with the following companies during the symposia: \n\n\n\n\nCarl Zeiss AB\n\n\n\nBioNordika AB\n\n\n\nTdB Labs AB\n\n\n\nMicromedic AB\n\n\n\nBruker Nordic AB\n\n\n\n10x Genomics Sweden\n\n\n\n\nCompany contact Erika Erkstam\, erika.erkstam@SciLifeLab.uu.se. \n\n\n\nIn compliance with GDPR regulations\, conference participants may not be added to company newsletters\, mailing lists\, or similar subscriptions without their explicit consent. \n\n\n\nRegistration\n\n\n\nThe registration deadline is March 3. To avoid empty seats\, registration will remain open until the event begins\, BUT registering after March 3 requires you to write your name on a name tag at the on-site registration. Unfortunately\, we cannot accommodate allergies or dietary preferences for those who register after March 3. \n\n\n\nMarch 4: The event has reached full capacity\, so a waiting list has been activated. If you sign up for the waiting list\, you will automatically receive an email when a spot becomes available. You must accept within 24 hours to secure the spot. If you decline\, the offer will go to the next person on the waiting list. \n\n\n\nRegistration\n\n\n\nCancellation\n\n\n\nTo minimize empty seats and food waste\, you must cancel your registration if you are unable to attend the symposia. Cancel via the Confirmation email or send an email to events@scilifelab.se. \n\n\n\n\n\n\n\nInvited speakers\n\n\n\nDownload the Speaker abstracts: \n\n\n\nDDLS CMB SpeakersDownload\n\n\n\nMarta Carroni\, SU\nTitle of talk: Structural basis for bacterial protein disaggregation and proteolysis  \n\n\n\nAbstract: Protein homeostasis is meticulously maintained across all cells\, spanning from archaea to humans. Any deviation from the equilibrium of the proteome\, induced by stress or cellular aging\, leads to the accumulation of misfolded proteins\, contributing to cellular toxicity. A complex proteostasis network actively manages misfolded proteins through processes such as refolding\, degradation\, or sequestration into intracellular inclusions. Integral to this protein quality control system are ATPases from the AAA+ superfamily (ATPases Associated to a variety of cellular Activities). \n\n\n\nThese AAA+ proteins\, universally present in organisms\, share a common structural fold for ATP hydrolysis\, but each possesses distinct function-specific domains\, enabling specialization in particular cellular activities and interactions with regulatory protein partners. \n\n\n\nOur work focuses on the structural investigation of bacterial Hsp100 AAA+ chaperones involved in protein quality control. We aim at understanding their fine-tuned regulation\, which is absolutely required by the bacterium to survive harsh environment conditions and useful for us in the effort of killing pathogenic bacterial strains. Using cryo-EM in combination with biochemical functional assays\, we can describe the molecular tuning mechanisms used by bacteria to assure the disaggregation or proteolysis of toxic protein species only\, while leaving intact functional protein molecules. \n\n\n\nBio: Marta Carroni is the Head of the Swedish National Cryo-EM Facility at SciLifeLab in Stockholm\, whose start and development she drove since its institution in 2016. She is a trained structural biologist and more specifically an expert in cryo electron microscopy (cryo-EM)\, technique on which she received extensive training since 2007 first at Imperial College London and then at Birkbeck College London\, under the supervision of Helen Saibil. Marta Carroni has initiated and trained in electron microscopy and image processing a large number of researchers in Sweden and abroad; she is often invited as teacher at cryoEM symposia and workshops. For this contribution\, she has been named one of the female innovators by the Italian Association of Women Inventors and Innovators in 2018 and awarded the Hugo Theorell price in 2023. Since 2020\, she is also the director of the Cellular and Molecular Imaging platform at SciLifeLab where she oversees the integration between different imaging modalities. Since 2022\, thanks to fundings form KAW\, SSF and support from Stockholm University\, she can run independent research projects with her group\, composed of 2 PhD students and 2 postdocs\, mainly looking at AAA+ molecular motors and their regulatory mechanisms in bacterial and human systems. The group often hosts master and Erasmus students and\, while developing an independent research path\, fosters many collaborations in Sweden and abroad.  \n\n\n\n\nJan Ellenberg\, Director SciLifeLab\nTitle of talk: Quantitative Imaging of Protein Networks and Genome Structure in Single Human Cells and an Outlook on Alpha Cell \n\n\n\nAbstract: The rapid development of new imaging technologies allows unprecedented insights into the molecular machinery inside living cells and organisms. For the first time\, light and electron microscopy have molecular sensitivity and resolving power in situ\, and\, if used together\, can connect structural detail with molecular dynamics of the whole cell. Aided by machine learning driven image analysis powered by open sharing of image data\, this provides unprecedented opportunities for new insights into the molecular mechanisms that drive life’s core functions at the scale of the cell. \n\n\n\nI will present the progress we have made to study one of life’s most fundamental functions\, cell division\, by mapping the dynamic protein network\, assembly of individual protein complexes and genome re-folding that drive it. Our work has studied cell division in human cancer cells and early mammalian embryos using advanced cross-scale imaging methods\, including light-sheet\, quantitative fluorescence correlation spectroscopy (FCS)-calibrated\, super-resolution and correlative light and electron microscopy. The quantitative integrated molecular data that these new technologies deliver\, allow us to better understand how the molecular machinery functions in space and time to ensure faithful cell division and prevent the errors that underlie congenital disease\, infertility and cancer. \n\n\n\nBio: Since July 2024\, Professor Ellenberg is appointed Director of SciLifeLab. Jan Ellenberg is distinguished for many contributions to the cell biology and imaging field. The majority of these were made at the European Molecular Biology Laboratory (EMBL) where he is Senior Scientist and Head of the Cell Biology and Biophysics Unit. His major research contributions cover several aspects of the cell division cycle and nuclear organization\, including systematic analysis of mitosis\, nuclear pore complex structure and assembly\, as well as chromatin organization and formation and segregation of mitotic and meiotic chromosomes.His goal has been to obtain structural and functional measures of the required molecular machinery inside cells using quantitative 4D imaging\, single molecule spectroscopy\, as well as light sheet and super-resolution microscopy\, which his group is constantly developing and automating to address all molecular components comprehensively. \n\n\n\n\nAnja Hauser\, DRFZ\, Germany\nTitle of talk: Functional\, multidimensional optical microscopy to analyze the function of myeloid cells during bone regeneration \n\n\n\nAbstract: Focusing on bone regeneration after injury\, we aim to understand how the tissue microenvironment affects the metabolism of myeloid cells in the bone marrow over time\, and how that impacts on cell function. We previously demonstrated that CX3CR1+ myeloid cells act as trailblazers for osteogenic type H vessels in the bone marrow. In order to analyze this process in 3D\, we developed a tissue clearing\, staining and light sheet fluorescence microscopy imaging pipeline called MarShie\, optimized to image the entire intact femur at subcellular resolution down to the deepest bone marrow regions. To analyze the three-dimensional dataset\, we applied a machine learning approach\, enabling us to segment thousands of cells. We find that during homeostasis CX3CR1+ myeloid cells localize in perivascular niches\, whereas CD169+ myeloid cells are dispersed in the parenchyma. After injury\, CX3CR1+ myeloid cells relocate and sequester the injury site prior to vascularization. Analysis of the femur after full osteotomy reveals that vessel sprouting is initiated at periosteal regions.Phenotypes and functions of immune cells are tightly linked to their metabolic profiles\, which in turn is affected by changes in the tissue microenvironment. We developed a lens implant for longitudinal intravital imaging of the mouse femur\, to enable micro-endoscopic fluorescence lifetime imaging (FLIM) for metabolic profiling at the same tissue region over the whole time course of bone healing. Using a reference system of fluorescence lifetimes derived from the ubiquitous metabolic co-enzymes NADH and NADPH (NAD(P)H)\, we can determine enzymatic activities in vivo. This approach allows us to identify a high degree of dynamics in dominant metabolic pathways for energy production. Additionally\, we distinguish pathways associated to cellular function and cellular state\, i.e. oxidative burst (NADPH oxidase activity) and dormancy or death. Under in vivo conditions\, myeloid cells with various metabolic profiles\, i.e. using other pathways for energy production than the anaerobic pathway associated with pro-inflammatory cells\, perform the oxidative burst necessary for phagocytosis. This demonstrates that a high metabolic flexibility of myeloid cells in vivo. \n\n\n\nBio: Anja Hauser holds the Professorship for Immune Dynamics at Charité – Universitätsmedizin Berlin\, and is head of Program Area “Cell and Tissue Immunology” at Deutsches Rheuma-Forschungszentrum Berlin\, Germany.Anja is a trained veterinarian who received her degree at the Tierärztliche Hochschule Hannover\, Germany. During her PhD thesis\, she investigated microenvironmental conditions that promote plasma cell longevity in tissues and became interested in the spatial organization of immune cells. Her postdoctoral work at Yale University School of Medicine focused on the dynamics of germinal center B cells\, which she analyzed by intravital microscopy. Since founding her own laboratory\, she has broadened her focus from the analysis of B cells to other adaptive and innate immune cells\, with a particular focus on the analysis of immune-stroma interactions and the signals that maintain chronic inflammation.Thus\, her work is centered around the basic concept that the immune system is organized in a spatial and temporal manner. To that end\, she develops and applies advanced imaging technologies. Anja is founding member of the European Society for Spatial Biology. \n\n\n\n \n\n\n\n \n\n\n\n\nSverker Holmgren\, Data Science Node\, Chalmers\nTitle of talk: National Data Services for Imaging in Cell and Molecular Biology \n\n\n\nAbstract: The Gothenburg DDLS Data Science Node is developing and deploying national services for managing and analyzing images in CMB. The node works together with the SciLifeLab Data Center\, and the areas covered are selected jointly with the DDLS Expert Group in CMB. Currently\, a national Open Microscopy Environment service (OMERO) for image data management and storage is being deployed\, and this will be connected to High Performance Computing resources for analysis\, using e.g. AI models\, and later also to image repositories for preservation and open sharing. In the next phase\, the underlying work setting up this national service is used to develop and deploy two other sets of prioritized services. \n\n\n\nBio: Sverker Holmgren is the Director of Chalmers e-Commons at Chalmers University of Technology\, where he is also a Professor of Scientific Computing. Chalmers e-Commons is Chalmers’ digital infrastructure for research\, providing integrated support to Chalmers researchers with a focus on data management\, analysis\, and data publication. Together with Chalmers Facility for Computational Systems Biology\, Chalmers e-Commons hosts the Gothenburg DDLS Data Science Node in Cell and Molecular Biology. Chalmers e-Commons is also the Chalmers node in other selected national and international digital infrastructures and initiatives\, e.g. the National Academic Infrastructure for Supercomputing (NAISS)\, the Swedish National Data Service (SND)\, and the National Research Infrastructure for Data Visualization (InfraVis). \n\n\n\nHolmgren has a long history of engaging in data and large-scale computing infrastructures locally\, nationally\, and internationally. Besides leading the local effort at Chalmers\, he is a member of national and international reference groups and initiatives on data management. Holmgren is a permanent Expert in the Swedish Delegation to the European Strategic Forum for Research Infrastructure (ESFRI)\, a member of the ESFRI IG\, and a Swedish Delegate in the European e-Infrastructure Reflections Group (e-IRG). Earlier\, Holmgren held a professorship at Uppsala University where he also served as the Dean of Mathematics and Computer Science for six years. \n\n\n\n\nRasmus Krogh Norrild\, DTU\, Denmark\nTitle of talk: High-throughput experimental approaches for quantifying the thermodynamics of biomolecular condensate formation \n\n\n\nAbstract: Biomolecular condensates (BMCs) are phase-separated and membraneless compartments enriched in specific biomolecules\, playing key roles in biological function and disease. Understanding how BMC formation depends on solution conditions\, amino acid sequence\, and nucleotide sequence is crucial\, particularly for applications in drug discovery. High-throughput methods are therefore highly valuable for large-scale screening and for elucidating the fundamental driving forces of condensate formation. In this seminar\, I will present Condensate Partitioning by mRNA-Display (CPmD)\, a novel high-throughput approach based on mRNA display (Norrild et al.\, bioRxiv 2024). CPmD enables the simultaneous analysis of partitioning behaviour for tens of thousands of peptides and their corresponding synthetic mRNAs within BMCs\, offering new insights into the thermodynamics of condensate formation. To validate CPmD\, we employed two microfluidics-based methods\, Capflex (Stender\, Ray\, Norrild et al.\, Nat. Commun. 2021) and TDIPS (Norrild et al.\, Angew. Chem. Int. Ed. 2024)\, both leveraging the commercially available FIDA1 microcapillary system. These methods demonstrate how proteome-scale CPmD data on peptide partitioning can directly inform on biomolecular condensate formation of the proteins from which the peptides originate. \n\n\n\nBio: I am a postdoctoral researcher at the Technical University of Denmark (DTU)\, specializing in protein biophysics. I have a MSc in Biochemistry from the University of Copenhagen and I did my PhD in Biophysics at DTU on Biophysics. My research focuses on understanding how protein structure\, stability\, and phase behavior contribute to cellular function and disease. I combine experimental and data-driven computational approaches to study and engineer dynamic proteins\, especially intrinsically disordered regions of these. My goal is to integrate quantitative biophysics with cell biology to uncover new insights into protein function in complex biological systems. \n\n\n\n\nWei Ouyang\, DDLS Fellow\, KTH\nTitle of talk: Unleash the Power of Generative AI for Data-Driven Cell Biology \n\n\n\nAbstract: This talk presents the ongoing work of AICell Lab (https://aicell.io) focusing on developing generative AI\, diffusion models for human cell modeling\, and AI-driven automation in microscopy and robotics. We focus on the development of the REEF Microscopy Imaging Farm\, which aims to create fully automated imaging systems that generate high-quality datasets for cell simulation. We are also building scalable platforms like ImJoy and Hypha\, which power the BioImage Model Zoo—a community-driven repository enabling easy AI model testing. Additionally\, our BioImage Chatbot\, an AI agent built on a bioimaging knowledge base\, is being extended for automated scientific discovery. These efforts converge in the Hypha platform\, connecting hardware\, AI models\, and users to advance whole-cell modeling and redefine in-silico research and drug discovery. \n\n\n\n\nErdinc Sezgin\, KI\nTitle of talk: Physical properties of cells and nanoscale bioparticles as new biomarkers of health and disease \n\n\n\nAbstract: Remodelling of our cells as response to environmental changes is essential for their survival and function. Although numerous studies aimed at finding protein markers during such cellular processes\, there is a major gap in our understanding of how collective biophysical properties of the cells (such as stiffness\, membrane fluidity\, viscosity etc) alter during these crucial biological processes. Similarly\, our understanding of how biophysical properties of cells change in diseases is also limited. To gain a thorough mechanistic perception of cellular processes and diseases\, it is essential to fill this gap and have a clear and quantitative picture of biophysical remodelling of the cells.We and others have made extensive effort to unravel the biophysical aspects of cells in a quantitative manner. To achieve this\, we developed advanced imaging approaches that could reveal the molecular details with very high spatiotemporal resolution. These technologies allowed us to see how biophysical properties of cells play crucial roles for signalling from molecular to cellular level. Although these technologies were extremely useful to study biophysical aspects of cellular life at the molecular level\, their low sampling (one cell at a time) has been a major obstacle to apply them to medical problems that require measuring thousands of cells. This can be overcome with high throughput methodologies that can robustly report on the ensemble biophysical properties of cells which require reliable reporters and instruments. Thus\, while developing advanced instrumentation\, we also develop reliable probes to quantify different biophysical properties of cells. Here\, I will discuss our approach from probe development to high throughput biophysical analysis \n\n\n\nBio: Erdinc Sezgin studied Genetics and Bioengineering at the Yeditepe University\, Istanbul Turkey. He next joined International Max Planck Research School for PhD in Dresden\, Germany. After graduation\, he obtained EMBO\, Marie Curie and Newton fellowships to perform his postdoctoral research in immunology and imaging at University of Oxford. Since 2020\, he has been leading his independent lab as an Associate Professor at Karolinska Institutet and SciLifeLab. He is currently an EMBO Young Investigator and a Visiting Faculty at University of Oxford. \n\n\n\n\nEduardo Villablanca\, KI\nTitle of talk: Unraveling the Molecular Architecture of the Intestinal Barrier: Insights from Spatial Transcriptomics \n\n\n\nAbstract: The complex cellular network that constitutes the intestinal barrier is crucial for maintaining health and preventing diseases. In this talk\, I will present the remarkable capabilities of spatial transcriptomics (ST) in unveiling the molecular organization of the entire colonic tissue during mucosal healing and tumorigenesis. By leveraging ST\, we revealed a previously undiscovered regionalization of the colon’s transcriptomic landscape under steady state conditions\, which undergoes dramatic changes during mucosal healing. We identified spatially organized transcriptional programs that define compartmentalized mucosal healing\, including regions exhibiting dominant wired pathways. Furthermore\, I will discuss the translational potential of our findings by mapping transcriptomic modules associated with human diseases. \n\n\n\nBio: Dr. Villablanca is a developmental biologist turned immunologist with expertise in cell migration and mucosal immunology. He began his research using zebrafish as an in vivo model before shifting his focus to immunology during his PhD in Molecular Medicine at San Raffaele University in Milan\, Italy. His interest in intestinal leukocyte trafficking led him to Harvard Medical School\, where he trained as a postdoctoral fellow in Dr. Rodrigo Mora’s lab. After four years\, he was promoted to Instructor in Medicine and joined Dr. Xavier’s lab to study inflammatory bowel disease (IBD) risk genes and their role in intestinal immune homeostasis.In late 2014\, Dr. Villablanca was recruited to establish his own laboratory at the Karolinska Institute’s Division of Immunology and Respiratory Medicine in Sweden. Now a Professor of Gastrointestinal Immunology\, Wallenberg Fellow\, and ERC awardee\, he leads a research team integrating developmental biology\, mucosal immunology\, and systems biology to uncover how intestinal homeostasis is maintained and how its disruption contributes to disease.Visit the Villablanca lab webpage here or watch the research video summary here.BsKy: @ejvillablanca.bsky.social \n\n\n\n\nFor questions about the Program\, please contact the Scientific Committee: \n\n\n\n\nIda-Maria Sintorn\, UU\n\n\n\nMarc Friedländer\, SU\n\n\n\n\nAbout the event\, please contact Project leader: Erika Erkstam\, Operations office\, SciLifeLab \n\n\n\nProgram\n\n\n\nDDLS-Symposium-PROGRAM-NY2Download\n\n\n\nMore information about the Data-driven Life Science Research area\n\n\n\n\n\n\n\nDDLS Cell and Molecular Biology URL:https://www.scilifelab.se/event/imaging-in-cell-and-molecular-biology/ LOCATION:Ångström Laboratory\, Lägerhyddsvägen 1\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/03/CMB_web.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250317T130000 DTEND;TZID=Europe/Stockholm:20250317T140000 DTSTAMP:20260408T005540 CREATED:20250303T110411Z LAST-MODIFIED:20250303T110412Z UID:10001503-1742216400-1742220000@www.scilifelab.se SUMMARY:PULSE Challenge: Selection and screening of antibody based drugs DESCRIPTION:This presentation will provide an overview of the selection and screening processes\, as well as future challenges for antibody-based drugs. It will be exemplified with data from one of Alligator Bioscience’s bispecific antibody drug candidates\, ATOR-4066. ATOR-4066 is a novel bispecific antibody constructed in the RUBY™ format using Alligator Bioscience’s Neo-X-Prime platform. It targets the tumor-associated antigen CEA (CEACAM5) on tumor cells and CD40 on myeloid cells. ATOR-4066 is designed to induce efficient CEA-conditional activation of myeloid cells\, facilitate the uptake of neoantigen-containing tumor-derived material\, and subsequently drive the cross-priming of tumor-specific T cells\, resulting in long-lasting anti-tumor activity. \n\n\n\nThe seminar series PULSE Challenge is connected to the MSCA co-funded* postdoctoral program SciLifeLab PULSE\, that will train 48 future leaders in life sciences. The program focuses on innovative\, fundamental and translational research carried out in supportive and diverse academic and industrial environments\, preparing postdocs with necessary skills for long-term career sustainability. Click HERE to find out more about SciLifeLab PULSE \n\n\n\n\n\n\n\nOn-line event via Zoom \n\n\n\nRegister Here\n\n\n\n\n\n\n\n\n\n\n\n\n\nPresenter: Dr Peter Ellmark\, PhDChief Scientific OfficerAlligator bioscience\, Lund\, Sweden \n\n\n\nAbstract:Antibody-based drugs have revolutionized the treatment landscape for numerous serious conditions\, with a global market size exceeding $250 billion. The success of these drugs can be attributed to their high specificity and versatility. Critical to the successful development of antibody-based drugs is the appropriate selection and screening methodology\, which ensures that drug candidates meet all key criteria for successful development. \n\n\n\nA short speaker biography:Peter Ellmark joined Alligator Bioscience in 2008 and serves as Chief Scientist. He holds a PhD and an adjunct professorship in Immunotechnology at Lund University and has more than 20 years’ experience of developing antibodies for immunotherapy of cancer. Dr. Ellmark´s research interest is focused on developing mono- and bispecific antibodies\, in particular CD40 and 4-1BB targeting therapies\, for tumor directed immunotherapy of cancer. URL:https://www.scilifelab.se/event/pulse-challenge-selection-and-screening-of-antibody-based-drugs/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/02/Bild1-e1770905208628.png END:VEVENT END:VCALENDAR