SciLifeLab

[The Svedberg seminar] - How to Terminate Transcription at the Right Place
2026-01-26 15:15 - 16:15 (Europe/Stockholm) | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Gene‑Wei Li

Associate Professor Massachusetts Institute of Technology (MIT), USA

Bio

Gene‑Wei Li is an Associate Professor of Biology at Massachusetts Institute of Technology (MIT) and an Investigator at Howard Hughes Medical Institute (HHMI). He earned a B.S. in Physics from National Tsinghua University (2004) and a Ph.D. in Physics from Harvard University (2010), followed by a postdoctoral fellowship at University of California, San Francisco (UCSF). His research focuses on how bacterial genomes encode quantitative control over protein production — exploring how cells optimize proteome composition through precise regulation of transcription, translation, and RNA processing.

How to Terminate Transcription at the Right Place

Precise transcription termination is essential for defining gene boundaries and achieving proper RNA output. I will discuss two recent advances regarding transcription termination in bacteria. First, we re-defined the features required for intrinsic terminators: in addition to the canonical hairpin and U-tract, two conserved sequence motifs are also necessary. This new definition quantitatively explains variations in termination efficiency and accurately pinpoints functional terminators genome-wide. Second, we showed that many bacteria have evolved purine-rich genes to avoid premature transcription termination, especially in species with “runaway transcription,” i.e., those uncoupled transcription-translation. This bias imposes strong evolutionary constraints on codon usage and the assimilation of foreign genes. Together, these principles illuminate the design principles of bacterial gene sequences and how genomes encode the correct endpoints of transcription

Host: Johan Elf johan.elf@icm.uu.se UU

Metabolomics in Life Science
2026-01-27 08:00 - 2026-01-28 15:00 | Väven, Storgatan 46A, Umeå, 90326, Sweden
After the great success of the 2024 Metabolomics in Life Science conference, the Organizing Committee is thrilled to announce the second edition in 2026!Date: 27-28 January, 2026Venue: Vävenscenen, Umeå

Umeå University warmly invites you to Metabolomics in Life Science 2026, showcasing the latest NMR- and MS-based metabolomics research from Sweden, the Nordics, and beyond. The conference brings together researchers from around the world to share knowledge and discuss advances in areas like clinical and precision medicine, plant metabolomics, spatial and single-cell metabolomics, multi-omics, and computational/AI applications.

The event is organized by SciLifeLab platforms in Umeå: Swedish NMR Centre (SNC), Swedish Metabolomics Centre (SMC), and Computational Analytics Support Platform (CASP).

The program includes six keynote speakers from leading institutions, plus an industry exhibition showcasing the latest technologies and services in metabolomics research.

Registration is now open – Register here

Questions? Contact:

Ilona Dudka – ilona.dudka@umu.se

Kate Bennett – katie.bennett@umu.se

Looking forward to welcoming everyone in Umeå in January 2026!

Read more

OrganizersSwedish Metabolomics Centre (SMC)

NMR Core facility

Computational Analytics Support Platform (CASP)

How to Terminate Transcription at the Right Place
2026-01-27 14:00 - 15:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Gene‑Wei Li, Associate Professor Massachusetts Institute of Technology (MIT), USA

Abstract

Precise transcription termination is essential for defining gene boundaries and achieving proper RNA output. I will discuss two recent advances regarding transcription termination in bacteria. First, we re-defined the features required for intrinsic terminators: in addition to the canonical hairpin and U-tract, two conserved sequence motifs are also necessary. This new definition quantitatively explains variations in termination efficiency and accurately pinpoints functional terminators genome-wide. Second, we showed that many bacteria have evolved purine-rich genes to avoid premature transcription termination, especially in species with “runaway transcription,” i.e., those uncoupled transcription-translation. This bias imposes strong evolutionary constraints on codon usage and the assimilation of foreign genes. Together, these principles illuminate the design principles of bacterial gene sequences and how genomes encode the correct endpoints of transcription.

Biography

Gene‑Wei Li is an Associate Professor of Biology at Massachusetts Institute of Technology (MIT) and an Investigator at Howard Hughes Medical Institute (HHMI). He earned a B.S. in Physics from National Tsinghua University (2004) and a Ph.D. in Physics from Harvard University (2010), followed by a postdoctoral fellowship at University of California, San Francisco (UCSF). His research focuses on how bacterial genomes encode quantitative control over protein production — exploring how cells optimize proteome composition through precise regulation of transcription, translation, and RNA processing.

Host; Vicente Pelechano vicent.pelechano@scilifelab.se

High-Speed AFM and Cryo-EM: Dynamics and Structures of Membrane Proteins
2026-01-27 15:15 - 16:15 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Simon Scheuring

Weill Cornell Medicine, USA

Simon Scheuring is Distinguished Professor of Anesthesiology Research in the Department of Anesthesiology at Weill Cornell Medicine in New York, USA.

He is a trained biologist (Biozentrum, University of Basel, Switzerland). During his MSc and PhD, he learned electron microscopy (EM) and atomic force microscopy (AFM) for the structure determination of membrane proteins such as aquaporins and sugar transporters. During his postdoc and as research assistant (Institut Curie, Paris, France), he learned membrane physical chemistry and developed AFM for the study of native membranes and ventured into setting up his lab as a junior research director at the Institut Curie. Promoted to senior research director, he built a larger laboratory in Marseille (INSERM / Aix-Marseille Université, France). In 2017, he moved to Weill Cornell Medicine, where he got appointed as Professor in the Department of Anesthesiology (WCM, New York, USA). Simon Scheuring’s laboratory develops and applies AFM-technologies for the study of membrane phenomena, such as membrane protein structure, assembly, diffusion, and conformational dynamics of unlabeled single molecules, bridging structure and function. Over the past years, his laboratory has been instrumental in the development of High-Speed AFM (HS-AFM) methods, extracting quasi-atomic structural details from single molecule AFM data, and reaching millisecond temporal resolution for the analysis of conformational dynamics. In recent works, his laboratory combines HS-AFM with cryo-EM to acquire an integrated understanding of the dynamics and structures of membrane proteins.

Abstract

High-speed atomic force microscopy (HS-AFM) is a powerful technique that provides dynamic movies of biomolecules at work. First, I will briefly review our recent developments to break temporal limitations to characterize molecular dynamics by developing HS-AFM line scanning (HS-AFM-LS) and HS-AFM height spectroscopy (HS-AFM-HS) [1], and resolution limitations by developing Localization AFM (LAFM) [2]. Then, I will detail how we used HS-AFM to analyze membrane-embedded TRPV3 at the single-molecule level, and discovered a previously unobserved, transient, and reversible pentameric state of TRPV3, while cryo-EM analysis allowed to resolve the first structure of a pentameric TRP channel [3,4]. Finally, I will report about our most recent efforts to develop and apply 3D-AFM for the characterization of the water structure on protein surfaces [5].

References:

[1] Heath et al., Nature Communications, 2018, 9(1):4983, High-Speed AFM Height Spectroscopy (HS-AFM-HS): Microsecond dynamics of unlabeled biomolecules.

[2] Heath et al., Nature, 2021, 594(7863):385–390, doi:10.1038/s41586-021-03551-x, Localization Atomic Force Microscopy.

[3] Lansky et al., Nature, 2023, 621(7977), 206–214, doi:10.1038/s41586-023-06470-1, A pentameric TRPV3 channel with a dilated pore.

[4] Lansky et al. Nature Communications, 2025, 16(4520). https://doi.org/10.1038/s41467-025-59798-9, Structural dynamics and permeability of the TRPV3 pentamer. [5] Ma et al., submitted, 2025, Aquaporins destructure water above the pore.

Host: Stavros Azinas stavros.azinas@scilifelab.se

Beyond Compliance: Using Data Management Plans to drive research efficiency
2026-01-28 10:00 - 11:00
A Data Management Plan (DMP) shouldn’t just be a document you file and forget to satisfy a funder. When done correctly, it serves as a vital project roadmap that prevents data loss, simplifies collaboration, and saves you weeks of tedious “data cleaning” at the end of your project.This workshop introduces the concept of data management planning as a catalyst for more efficient, high-impact research as well as a demo of the SciLifeLab Data Stewardship Wizard (DSW).

You find SciLifeLab Data Stewardship Wizard (DSW) here

There will also be time for questions and discussion. You are welcome to submit questions in advance to data-management@scilifelab.se

When: January 28th 10-11 CET Zoom (Please note that the time is 10-11 Stockholm)

Speakers: Data stewards Karin Granström and Marian Vrettou, NBIS. For the discussion sessions data stewards Katarina Öjefors Stark and Mirjam Walpot from SciLifeLab Data Centre will also join.

Register: Register before Jan 27 at 24.00

Target audience: researchers, post docs, fellows, and others interested.

Recording: https://youtu.be/nwTlWnqtN1o

For questions about the event contact SciLifeLab Data Management data-management@scilifelab.se

Register

Campus Solna Seminar Series: Woonghee Kim & Laura Steponaviciute
2026-01-29 12:00 - 13:00 | Becquerel, SciLifeLab, Tomtebodavägen 23, Solna
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Woonghee Kim

Adil Mardinoglu – alpha 6

Phospho-JNK agonists show promising effects for the treatment of hepatocellular carcinoma

Laura Steponaviciute

Simon Elsässer – alpha 4

Sense labelling in mESC for capturing dynamic proteome shifts in lineage restriction

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

Calls for new project support in Chemical Biology and Drug Discovery
2026-01-30 12:00 - 13:00 | Online event via Zoom
The Chemical Biology Unit (CBCS) and the Drug Discovery and Development (DDD) platform at SciLifeLab have calls out for projects.

CBCS is seeking projects in Chemical Biology that include assay development for small-molecule screening and profiling, as well as enabling chemistry.

For more information, please visit www.cbcs.se.

The DDD platform is looking for new project proposals for drug discovery. All therapeutic modalities that can be developed in collaboration with the DDD platform at SciLifeLab are of interest, including small molecules, antibodies, oligonucleotides and new modalities.

Some users and projects are at the intersection between chemical biology and drug discovery. This webinar aims to guide users to the call that best suits the needs of their project

Register here!

Organizer: the Chemical Biology Consortium Sweden and the Drug Discovery & Development platform

Information seminar on KAW/SciLifeLab Proof of Concept call for grants 2026
2026-01-30 13:00 - 14:30 | Online event via Zoom
The 4th call for KAW/SciLifeLab Proof of Concept grants in Life Science is open for applications!

The purpose of the Proof of Concept grant is to bridge the gap from academic research to innovations in life science. The grant gives researchers the opportunity to develop their early-stage discoveries towards validated methods, products or processes and provides the opportunity to carry out activities that validate and accelerate the development of the project and prepare for innovation and commercialization.

Watch the seminar below to learn more about the call. ↓

Register to the Seminar

Program

13.00The KAW/SciLifeLab Proof of Concept grants in Life Science, Olli Kallioniemi, Professor of Molecular Precision Medicine, KI, Lilian Wikström, KAW13.20Project presentation – Marie Jeansson, KITherapeutic intervention to slow progression of chronic kidney disease13.40Project presentation – Pål Stenmark, Stockholm UniversityInnovative therapeutic toxins for the treatment of neuromuscular disorders14.00Open discussionModerator – Isolde Palombo, KTH

Application period

Call opens: January 13, 2026Call closes: February 20, 2026 at 13:00

Read more about the Call

Research seminar for Associate Senior Lecturer, SciLifeLab Fellow position in inflammation research
2026-02-02 13:00 - 15:45 | Navet, SciLifeLab Uppsala, SciLifeLab Uppsala, BMC C11, Husargatan 3, Uppsala, 75237, Sweden
Welcome to the seminars and discussions with candidates for the SciLifeLab Fellow position in inflammation research at Uppsala University.

Date: February 2, 2026

Time: 13:00 – 15:30

Location: The Triple room in SciLifeLab Navet, Entrance C11 at BMC, Husargatan 3, Uppsala. Or Zoom.

Organized by the SciLifeLab Uppsala University Committee

Registration

Please register to reserve a seat onsite or get the Zoom link to attend online.

Join the Zoom meeting by following the “Link to online event” in the Confirmation email. We will also send an e-mail reminder the day before the event with a button to “Join the Zoom meeting”.

Zoom attendees: You will be placed in a waiting room until the host opens the meeting. You will be muted and off camera upon entry. We kindly ask participants to remain muted during the presentations and to submit questions in the Q&A field. The Host will address questions after each presentation.

Registration

Program

13:00 Welcome, Hosts Prof. Anna Dimberg and Prof. Aristidis Moustakas

13:05 Expanding Kidney-Resident Bregs In Vivo: A New Level on Kidney Inflammation, Kailash Singh

13:40 Precision Targeting of Inflammation Beyond Corticosteroids, Aida Paivandy

14:15 Short break

14:25 Restoring immune tolerance in autoimmunity: autoreactive B cells and redox-controlled cellular strategies, Mike Aoun

15:00 Differential immune responses in Necrotizing Soft Tissue infections, Laura Palma Medina

15:30 Summary of the research seminars, Prof. Aristidis Moustakas

Program2.0_260202_Fellow position seminarDownload

From Scientific Ideals to Practical Open Science: How reporting on study limitations can diminish Avoidable Research Waste
2026-02-03 11:00 - 12:00 | https://uu-se.zoom.us/j/65990273341?from=addon
What can a sociological framework from the mid-20th century teach us about today’s open-science movement? Surprisingly much.In this virtual seminar, we revisit Robert Merton’s CUDOS framework—Communalism, Universalism, Disinterestedness, and Organized Skepticism—and explore why these four principles continue to shape how we think about responsible and transparent research. The presentation will place special emphasis on organized skepticism: what it means in practice, why it is crucial for research credibility, and how fostering a culture of constructive critique can directly reduce avoidable research waste. The talk will also introduce practical examples of how these ideals can be operationalized today. You’ll hear about work on the automatic detection of study-limitation statements in scientific texts, its implementation in the research-quality tool ScreenIT, and how such tools can support reproducibility and stronger research assessment. The seminar will end with findings from a recent study on researchers’ adherence to a 14-item checklist for responsible and open research between 2020 and 2024.This session will appeal to anyone interested in:

research transparency and rigor

the philosophical roots of open science

practical tools for improving research quality

shaping a scientific culture aligned with modern open-science values

Presenter: Gerben ter Riet MD PhD – Amsterdam University of Applied Sciences (AUAS) – Clinical epidemiologist, Open Science Advisor, Member of the Committee for Research Integrity (at AUAS), and advisory board member of the Netherlands Research Integrity Network (NRIN).

Recording: Recording will be available after the event on: https://www.youtube.com/@SciLifeLabTalksTraining Slides: The slides will be available after the event.

More information

This event is part of the SciLifeLab Open Science seminar series, an event series by the SciLifeLab Data Centre and NBIS joint Data Management team.The goal of the events in this seminar series is to provide interesting interactive seminars around topics related to Research Data Management and Open Science in general, and to foster discussions around best practices.

Research Data Management (RDM) concerns the organization, storage, preservation, and sharing of data that is collected and analyzed during a research project. Proper planning and management of research data will make project management easier and more efficient while projects are being performed. It also facilitates sharing and allows others to validate as well as reuse the data.Open Science is a set of principles and practices that aim to make scientific research from all fields accessible to everyone for the benefits of scientists and society as a whole. Open science is about making sure not only that scientific knowledge is accessible but also that the production of that knowledge itself is inclusive, equitable and sustainable.

The events are open to everyone working at or affiliated with a Swedish research institute or university. We welcome all researchers, educational professionals, staff, RDM professionals, and others with an interest in life sciences, from all university levels. The events are informal and inclusive, so feel welcome to join and participate in our interesting discussions!

The events will be recorded and published openly after the seminars on the SciLifeLab YouTube channel. The slides will be made available at our SciLifeLab Data Repository. More information about SciLifeLab Data Centre and NBIS joint Open Science seminar series: https://www.scilifelab.se/data/scilifelab-data-management-seminar-series/

If you have suggestions for topics or presentations, please contact us at data-management@scilifelab.seFor more information or inquiries, please contact us at data-management@scilifelab.se

Introduction to SciLifeLab Protocols
2026-02-04 10:00 - 11:00
SciLifeLab Data Centre is delighted to invite you to a webinar introducing SciLifeLab’s instance of protocols.ioSciLifeLab provides a dedicated institution-wide instance of protocols.io, giving the SciLifeLab community access to a useful platform for creating, organizing, and openly sharing experimental and computational protocols. Protocol’s ensures that methods are citable, discoverable and kept up to date through allowing versioning. Additionally, the use of Protocol’s align with SciLifeLab’s efforts around open science and reproducibility. The webinar will consist of broad introduction to the service by protocols.io team that will be followed by SciLifeLab Data Centre’s practical advise on accessing premium SciLifeLab workspace and questions from the audience.

When: Feb 4th 2026 10-11 CET

Speakers: Joanna Sendecka, SciLifeLab Data Centre, and Julia Kurz from protocols.io

Where: Zoom ( link will be sent to registered participants)

Register

This webinar, will walk you through what this service offers and how you can benefit from joining it.

Discover what protocols.io service is and how it can improve your research: save time, ensure consistent quality across experiments, and reduce errors through well-structured, scalable, step-by-step protocols.

Learn about SciLifeLab’s own institutional Protocol’s workspace, available to our community with premium features included.

Understand how protocols.io can enhance reproducibility and FAIR compliance to better visibility and formal credit for method development.

Learn how to access your Protocol’s premium account and the support offered from Data Centre team to get started

We are looking forward to meeting!

For questions contact SciLifeLab Data Centre datacentre@scilifelab.se

High-throughput Electrophysiology & Lipophilic Potassium Channel Activators
2026-02-05 08:00 - 2026-02-06 17:00 | KBC Building Umeå, Linneaus Väg 6, Umeå
Feb 6th two on-site seminars at the Lilla Hörsalen, KBC Umeå University:13.00 -14.00 High-throughput Electrophysiology14.00 -15.00 Lipophilic potassium channel activators possible anti-seizure and anti-arrhythmic treatments

One-on-one meetings with the unit will be possible in the meeting room Bryggan Thursday 5th 8-17 and Friday 6th 8-12. Take the chance to discuss how your research questions can be answered through analyses of ion channels.

Registration

The Electrophysiology unit, a recent addition to SciLifeLab’s range of advanced research infrastructures, is equipped with automated patch-clamp instrumentation, and supports a wide range of electrophysiological studies involving both voltage-gated and ligand-gated ion channels, including pharmacological screening, cardiac safety assessments, and biophysical investigations.

Professor Fredrik Elinder is a molecular neurobiologist at Linköping University, internationally recognized for his contributions to the physiology and pharmacology of voltage‑gated ion channels. His research has advanced fundamental understanding of how voltage sensors operate, how ion‑channel gating is regulated, and how small molecules and lipids can modulate channel activity. Elinder’s group investigates mechanisms that control neuronal excitability, including how altered voltage thresholds contribute to disorders such as epilepsy and pain.

Presenters

Fredrik Elinder, Professor, Site director SciLifeLab Linköping, Chemical Biology Consortium Sweden (CBCS), and Department of Biomedical and Clinical Sciences (BKV), Linköping University

Nina Ottosson, Research Coordinator, Chemical Biology Consortium Sweden (CBCS), and Department of Biomedical and Clinical Sciences (BKV), Linköping University

https://www.umu.se/en/events/high-throughput-electrophysiology-_12156373

User meeting for your multi-modal research projects
2026-02-05 09:00 - 10:30
Boost your research — Book a private SciLifeLab planning and feedback session for your multi-modal research projects!

Once we have received your registration, you will be sent the link to the online meeting.

Register here

Date: February 5 9.00 – 10.30 Registration deadline: January 30

Multimodal molecular profiling and novel computational methods are transforming life science research, but also pose new challenges in study design, project resource planning and data management. SciLifeLab is a national resource of unique technologies and expertise available to life scientists, in areas such as biomedicine, ecology and evolution, aiming to bring scientists together across traditional boundaries and foster collaborations with industry, health care, public research organizations and international partners.

The first Thursday of every month at 9.00 (except July and August), SciLifeLab offers an opportunity to jointly meet with representatives across the SciLifeLab service platforms, to get feedback and help to plan, design, and refine new or ongoing multimodal research projects. Your project plans are discussed privately and remain confidential, and information will not be shared outside of the service platforms. Note that for most studies, follow-up meetings will be needed, but our aim for these meetings is to provide an easy-access entry point for an overarching planning of multimodal studies.

For studies focusing on a single technology only, please primarily contact our service platforms directly as described at the SciLifeLab homepage.

To make the best out of the allotted time, we ask you to provide some background information about your project, to help us ensure that the relevant experts are available to discuss your study.

Webinar: Current state of AI agents in life sciences
2026-02-05 10:00 - 11:00 | Online event via Zoom
Title: Current state of AI agents in life sciences

Speaker: Mahbub Ul Alam (AI Data Engineer, SciLifeLab Data Centre)

Where and when: February 5, 2026 at 10:00-11:00 Stockholm time, online. Registration is open till February 5 at 9:00.

Abstract: AI agents are emerging as autonomous systems that orchestrate scientific workflows by interacting with digital tools and data sources. These have various implications for life science research. They can, for example, simplify complex analyses by automating data integration, run computational models, and coordinate experimental steps, making research pipelines more efficient and reproducible. In this online webinar we will give an introduction into what AI agents are, discuss their potential in life sciences, and give an overview of the most recent popular AI agent platforms that have emerged in the past months/year.

This is an introduction-level webinar where we will give a basic overview of AI agents. For more in-depth discussion and hands-on workshop consider, for example, this on-site workshop.

Target audience: Anyone working in or with life science research is welcome.

Register to join the event

For questions about the events please contact the organizing team by emailing datacentre@scilifelab.se

Scientific lead: Prof. Ola Spjuth, SciLifeLab Data Centre and Uppsala University

Contact information: datacentre@scilifelab.se

Campus Solna Seminar Series: Marko Ludaic & Inês Cunha
2026-02-05 12:00 - 13:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Marko Ludaic

Arne Elofsson – gamma 6

Limits of deep-learning-based RNA prediction methods

Inês Cunha

Juliette Griffié – gamma 6

Interpreting Microscopy Images with Machine Learning

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

Automated morphological profiling at scale for drug discovery, target identification and drug repurposing
2026-02-05 14:00 - 15:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Welcome to a seminar with Shantanu Singh in the Chemical Biology Seminar Series!

“Automated morphological profiling at scale for drug discovery, target identification and drug repurposing”Shantanu Singh, Ph.D. & Senior Group LeaderBroad Institute

We will meet up with individuals who do not have access to SciLifeLab in the reception at 13.50.

PULSE Challenge: From Serendipity to Design Principles Molecular Glues as a Prelude to RIPTACs
2026-02-09 15:00 - 16:00 | Online event via Zoom
Traditionally viewed as inhibitors, small molecules have evolved through the discovery of molecular glues—compounds that create function by stabilizing protein-protein interactions. This shift from serendipitous discovery to “induced proximity” has expanded the druggable proteome and redefined how we control cellular behavior.

This talk traces the evolution of molecular glues, framing them as versatile proximity-inducing agents rather than just degradation tools. I emphasize their impact on our understanding of protein surfaces and cellular organization. The second half introduces Regulated Induced Proximity Targeting Chimeras (RIPTACs). I highlight HLD-0915, a novel RIPTAC targeting prostate cancer. In preclinical models, HLD-0915 demonstrated tumor regression and a favorable therapeutic index, even in drug-resistant cases. Finally, I present Phase 1 data from mCRPC patients, showing strong tolerability and encouraging anti-tumor activity in heavily pretreated populations.

Host: Vasanthanathan PoongavanamModerator: Per Arvidsson

The seminar series PULSE Challenge is connected to the MSCA co-funded* postdoctoral program SciLifeLab PULSE, that will train 48 future leaders in life sciences. The program focuses on innovative, fundamental and translational research carried out in supportive and diverse academic and industrial environments, preparing postdocs with necessary skills for long-term career sustainability. Click HERE to find out more about SciLifeLab PULSE

On-line event via Zoom

Register Here

Presenter: Dr. Muthukumaran Venkatachalapathy

Biography:Dr. Muthukumaran Venkatachalapathy is currently an Associate Research Scientist in the Department of Chemistry at Yale University (with Professor Craig Crews and Prof David Spiegel). With a strong background in Chemical Biology, he earned his Ph.D. from the Max Planck Institute in Dortmund, Germany. His research interests focus on developing novel chemical biology modalities for targeted protein degradation and therapeutic discovery

SBDI Days 2026 -Artificial Intelligence in Ecology and Biodiversity Research
2026-02-10 08:30 - 2026-02-11 17:00 | Swedish Museum of Natural History, Frescativägen 40, Stockholm, Stockholm, 114 18, Sweden
Artificial Intelligence is no longer just a tool. It is becoming a vital partner in the quest to understand and protect biodiversity. SBDI Days 2026 will explore this transformative partnership under the theme: AI and Biodiversity: a Perfect Pair!

The Planetary Biology Strategic Area is pleased to team up with the Swedish Biodiversity Data Infrastructure (SBDI) for this event that dives deep into the future of Ecology and Biodiversity Research.

Highlights of the program:

Talks on using AI in Biodiversity Research and monitoring, pros, cons and ethics

Poster sessions

Workshops on FAIR data principles, tools to integrate biodiversity monitoring data from different platforms, building AI applications within ecology and biodiversity, and using eDNA data within the SBDI.

Early career researchers are warmly encouraged to present their work.

Abstract submission for poster or oral presentation are open till December 15, 2025.

Check out the conference website to dive into the program and register

Conference website

Building and sharing AI applications within ecology and biodiversity
2026-02-10 16:00 - 17:30
This workshop is part of the SBDI Days 2026. In order to take part, you need to register for the main event and select this workshop.

Title: Building and sharing AI applications within ecology and biodiversity.

Organizer: SciLifeLab Data Centre (AI Data Engineers from the SciLifeLab Serve team).

Where and when: February 10, 2026 at 16:00-17:30 at the Museum of Natural History in Stockholm. Address: Frescativägen 40, 114 18 Stockholm.

Abstract: As more researchers in ecology and biodiversity build machine learning models, it is important to find ways to make these models useful for the researcher community or general public. One way to do this is to share the models as web applications with an easy-to-use interface. Users of the models can then adjust parameters or submit their own input and see the result generated by the underlying model. This tutorial is aimed at PhDs and researchers working within ecology and biodiversity who work with machine learning models but do not have the skills to build applications for the web. During the tutorial we will start from a trained model and demonstrate step by step how you can create a graphical user interface for your application, prepare it for deployment, and make it available on the web with a URL. We will demonstrate the use of specific tools which make this process easy and doable in under an hour.

Expected outcomes: Participants will have an overview of various open-source tools for creating applications out of machine learning models. Furthermore, they will have practices creating an application using one such tool or perhaps already have a demo of an application with their own model. Participants will have knowledge about options for hosting their applications and making them available to the general public or to colleagues.

Register to join the event

For questions about the events please contact the organizing team by emailing serve@scilifelab.se

Contact information: serve@scilifelab.se

Public hosting of Shiny apps: hands-on workshop
2026-02-10 16:00 - 17:30
This workshop is part of the SBDI Days 2026. In order to take part, you need to register for the main event and select this workshop.

Title: Public hosting of Shiny apps: hands-on workshop.

Organizer: SciLifeLab Data Centre (AI Data Engineers from the SciLifeLab Serve team).

Where and when: February 10, 2026 at 16:00-17:30 at the Museum of Natural History in Stockholm. Address: Frescativägen 40, 114 18 Stockholm.

Abstract: Researchers often create R Shiny applications as part of their projects and want to publish them as research output – as analysis tools with a graphical interface, as supplementary materials for publications, in order to make annotation easier, etc. In order to make Shiny apps available to the collaborators or general public, they need to be hosted somewhere and have a URL. We will start this workshop by giving an overview of what it means to create and publish Shiny apps as researcher in terms of institutional and funder requirements. We will then take a look at different hosting options for Shiny apps. During the hands-on part, we will focus on packaging Shiny apps for hosting as Docker images. Together with the participants, we will step-by-step package and publish an example Shiny app or the participants’ own Shiny app. If you are a researcher with an existing Shiny app you’d like to host, or if you plan to build a Shiny app in the future, this workshop is for you. If you already have a Shiny app you would like to host, bring it, and we will help you with it.

Expected outcomes: After this workshop, the participants will both have an understanding of working with Shiny apps within research projects in a Swedish university context and have practical knowledge about public hosting of Shiny apps.

Register to join the event

For questions about the events please contact the organizing team by emailing serve@scilifelab.se

Contact information: serve@scilifelab.se

Campus Solna Seminar Series: Humam Siga & Florian Weber
2026-02-12 12:00 - 13:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Humam Siga

Afshin Ahmadian – alpha

Florian Weber

Erdinc Sezgin – gamma 3

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

PULSE Challenge: The Discovery of Seqitope and Opti-mAb Technologies
2026-02-12 15:00 - 16:00 | Online event via Zoom
The Seqitope® and Opti-Mab® technologies originated from projects together with SciLifeLab DDD. Seqitope® is a high-resolution epitope mapping platform that combines large-scale wet-lab screening with advanced bioinformatics. By utilizing phage display of libraries containing millions of mutated antigen variants, it goes far beyond classical alanine scanning. The platform uses next-generation sequencing to generate millions of reads per antibody, providing exceptional resolution. While initially mapping 30 antibodies manually, Seqitope® is now automation-compatible, scaling to hundreds of antibodies simultaneously. Validated on targets like CD19 and IL8, it generates data sets ideal for machine learning in antibody discovery.

Additionally, we introduce Opti-mAb®, engineered single-chain variable fragments (scFvs) designed to solve common issues like aggregation, low expression, and instability. These novel formats enhance therapeutic development for bispecific antibodies and cell-based therapies. Together, Seqitope® and Opti-mAb® represent a significant leap in the scalability and precision of antibody engineering.

Host: Kristian SandbergModerator: Anna Ridderstad Wollberg

The seminar series PULSE Challenge is connected to the MSCA co-funded* postdoctoral program SciLifeLab PULSE, that will train 48 future leaders in life sciences. The program focuses on innovative, fundamental and translational research carried out in supportive and diverse academic and industrial environments, preparing postdocs with necessary skills for long-term career sustainability. Click HERE to find out more about SciLifeLab PULSE

On-line event via Zoom

Register Here

Presenters: Dr. Daniel Johansson, PhD and CSO at AAX Biotech

Biography:Dr. Daniel Johansson, Chief Scientific Officer at AAX Biotech, where he has been actively involved for the past three years in developing novel antibody technologies. He earned his Ph.D. in molecular immunology from the Karolinska Institute, with a focus on antibody discovery and engineering. With over 20 years of experience across academia and the biotech industry, he co-founded AAX Biotech to translate solutions developed during a drug discovery and development (DDD) project into broadly applicable technologies. These efforts resulted in two proprietary platforms: Seqitope, enabling high resolution, high throughput epitope mapping, and Opti-mAb, facilitating high quality production of scFvs in CAR-T and bispecific antibodies—tools now positioned to support researchers and companies worldwide.

Dr. Mats AA Persson, PhD, KI and co-founder of AAX Biotech

Biography:Dr Mats Persson has worked with molecular biology tools at Karolinska Institutet to generate, characterize and engineer human monoclonal antibodies since a post doc period at Scripps Research Institute in La Jolla, USA, in the late 1980-ies. In particular, he has been focusing on applying the techniques for studying anti-viral antibodies. This led him to co-found Molecules of Man AB in 2005, a start-up devoted to commercialize antibodies to hepatitis C virus (HCV) for clinical use. However, those antibodies were overtaken by highly efficient small molecule drugs (inhibiting the virus’s own enzymes), and thus did not reach the market. Undeterred, he suggested a new infectious target for development of human antibodies at DDD. During this project, technical hurdles were encountered that gave rise to novel solutions. And by now, human monoclonal antibodies had revolutionized the pharma industry, with biopharma being the real driver for hundreds if not thousands of novel drugs. Indeed, it was not farfetched that solutions to problems shared by scores of biopharma projects could be worthwhile to explore commercially: AAX Biotech was born and incorporated for this purpose.

Industry and Academy Matchmaking for Joint DDLS Projects 2026
2026-02-12 15:30 - 17:30 | Life City, Solnavägen 3H, Stockholm, 113 64
To further support networking and the formation of collaborative projects within the SciLifeLab & Wallenberg National Program for Data-Driven Life Science (DDLS), a matchmaking event between industry and academia is organized by SwedenBIO and DDLS Research School at Life City, Hagastaden (Stockholm) 15:30-17:30 on Thursday 12 February. This “after work”-style event will contain information about the DDLS Research School, current and upcoming PhD and postdoc project calls, brief pitches from successful ongoing joint projects, mingle, drinks, and snacks.

Program

Registration 15:15Event start 15:30

Welcome and opening words

Introductions DDLS Research School PhD students and postdocs

Industry- Academy project pitches:

Sofia Larsson, Readily Diagnostics

Isac Stark, Antaros Medical

Industry presentations

Mingle until 17:30

Register here

Deadline for registration: 29 January 12:00

WELCOME!

Agentic AI in the life sciences - toward trustworthy research environments
2026-02-13 10:00 - 11:00 | Online event via Zoom
Sebastian Lobentanzer

NBIS and SciLifeLab Data Centre arrange an open SciLifeLab AI Seminar Series aimed at knowledge-sharing about Artificial Intelligence and applications in the Life Science community. The seminar series is open to everyone. The seminar is run over Zoom on the third Friday of the month during academic terms, typically between 10 and 11 am, with approx. 45 min presentation and 15 min discussion.

When: February 13, 10:00-11:00

Where: Zoom http://meet.nbis.se/ainw

Speaker: Sebastian Lobentanzer (Computational Biology at Helmholtz Center Munich). The speaker is a Principal Investigator at the Institute of Computational Biology at Helmholtz Center Munich since 2025, and in affiliation with the Open Targets group at the European Bioinformatics Institute (EMBL-EBI) since 2024. Sebasitian also serves as the head of Computational Biology at the German Center for Diabetes Research.

Read more about the speaker here .

Abstract

Agentic AI systems promise to improve the accessibility and efficiency of biomedical research, yet generic large language model (LLM)–based agents often lack the reliability, transparency, and reproducibility required for scientific use. We present BioChatter, a modular, ontology-grounded agentic AI framework designed as the basis for an Integrated Research Environment (IRE) for biomedicine. BioChatter orchestrates LLMs, biomedical knowledge representations, and domain-specific tools within transparent and auditable workflows, enabling domain-aware reasoning and traceable data flows from raw data to scientific conclusions.

Following a benchmark-first development paradigm, BioChatter supports systematic evaluation of agent behavior, reasoning strategies, and tool use prior to deployment. Using extensible interfaces such as the Model Context Protocol, the framework enables interoperable, community-driven extension while maintaining clear separation between reasoning, knowledge, and execution layers. By moving beyond chatbot-style interactions toward reproducible research workflows, BioChatter demonstrates how agentic AI can evolve from opaque assistants into trustworthy research partners for the life sciences.

To stay updated, you can join our email list by contacting Olga Dethlefsen (olga.dethlefsen@dbb.su.se) or Bengt Sennblad (bengt.sennblad@scilifelab.se).

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[The Svedberg seminar] - Super-resolution imaging of chromatin in health and disease
2026-02-16 14:00 - 15:00 | BMC Trippelrummet, Husargatan 3, entrance C11, Uppsala, Sweden
Melike Lakadamyali

Professor University of Pennsylvania, USA

Bio

Dr. Lakadamyali obtained her BS in Physics in 2001 from the University of Texas, Austin and her PhD in Physics in 2006 from Harvard University. Dr. Lakadamyali started her independent group at ICFO-Institute of Photonic Sciences in Barcelona in 2010 and was awarded tenure in 2015. In 2017 she moved to the University of Pennsylvania´s Department of Physiology at the Perelman School of Medicine as an Assistant Professor, was promoted to Associate Professor in 2020 and Full Professor in 2024.

Super-resolution imaging of chromatin in health and disease

Super-resolution microscopy has opened new possibilities for visualizing chromatin architecture in situ at nanoscale resolution. Leveraging quantitative super-resolution imaging, we revealed the heterogeneous nature of nucleosome folding and demonstrated that chromatin structure at both nano- and meso-scales is highly plastic, dynamically remodeling in response to chemical and mechanical cues in health and disease. By combining biologically interpretable feature extraction with machine learning, we further showed that cells can be accurately classified into distinct states based solely on their multi-scale chromatin organization, while also identifying the specific chromatin features that drive classification, thus offering mechanistic insight into cell-state regulation.

Host: Sebastian Deindl sebastian.deindl@icm.uu.se, UU

[The Svedberg seminar] - Microbiome data science for population-scale studies
2026-02-16 15:15 - 16:15 | BMC Trippelrummet, Husargatan 3, entrance C11, Uppsala, Sweden
Leo Lahti

Professor University of Turku, Finland

Bio

Leo Lahti is professor in Data Science at the University of Turku, vice chair of the National Coordination on Open Science in Finland, and a recent member of the global Bioconductor Community Advisory board. He obtained doctoral degree in applied probabilistic machine learning from Aalto University in Finland (2010) and had subsequently nearly a decade of international research experience in European labs. His research team focuses on computational microbiome research. For more information, see the research homepage datascience.utu.fi<http://datascience.utu.fi>

Microbiome data science for population-scale studies

Human microbiome is a major contributor to health and disease, driven by environment and lifestyle. We will discuss recent advances in population cohort studies linking gut microbiome, socio-demographic variation, and health, and the critical role of open data science frameworks in facilitating such research.

Host: Luisa Hugerth luisa.hugerth@scilifelab.se, UU

Microbiome data science for population-scale studies
2026-02-17 15:15 - 16:15 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Professor Leo Lahti, University of Turku, Finland

Biography

Leo Lahti is professor in Data Science at the University of Turku, vice chair of the National Coordination on Open Science in Finland, and a recent member of the global Bioconductor Community Advisory board. He obtained doctoral degree in applied probabilistic machine learning from Aalto University in Finland (2010) and had subsequently nearly a decade of international research experience in European labs. His research team focuses on computational microbiome research. For more information, see the research homepage datascience.utu.fi<http://datascience.utu.fi>

Abstract

Human microbiome is a major contributor to health and disease, driven by environment and lifestyle. We will discuss recent advances in population cohort studies linking gut microbiome, socio-demographic variation, and health, and the critical role of open data science frameworks in facilitating such research.

Host: Ander Andersson anders.andersson@scilifelab.se

DDLS Evolution & Biodiversity - Planetary Biology meeting
2026-02-18 13:00 - 17:30 | BMC Trippelrummet, Husargatan 3, entrance C11, Uppsala, Sweden
Welcome to this joint meeting between DDLS Evolution & Biodiversity and SciLifeLab Planetary Biology to discuss shared visions and goals, and potential initiatives in collaboration.

Agenda

13:00–13:05 | Welcome & objectives

13:05–13:40 | Presentation round

13:40–13:55 | DDLS EB: Vision, goals & ongoing activities. Sara Hallin

13:55–14:10 | Planetary Biology: Vision, goals & ongoing activities. Olga Vinnere Pettersson

14:10–14:20 | The Data Science Node in Evolution and Biodiversity. Henrik Lantz

14:20–14:30 | Joint reflections & clarifying common objectives

14:30–15:00 | Coffee break

15:00–15:30 | Looking ahead: 2026 planning

15:30–16:35 | Strengthening collaboration & joint initiatives

16:35–17:00 | Next steps & wrap-up

18:30 – | Dinner at Frans Bistro (Dragarbrunnsgatan)

Campus Solna Seminar Series: Tom Resink
2026-02-19 12:00 - 13:00 | Milkyway SciLifeLab Solna, Tomtebodavägen 23, Solna
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Tom Resink

Adnane Achour – gamma 4

From Structure to Immunogenicity: Exploring correlated dynamics of class I pMHCs

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

PULSE Challenge: Catalysis - A guiding principle for biochemistry and professional career development
2026-02-24 15:00 - 16:00 | Online event via Zoom
This seminar will describe Dr. Lorenz M. Mayr‘s experience in drug discovery from over 30 years in industry, academia, venture capital/financing and finally running Biotech startup companies. He is driven by his passion for science, interdisciplinary research and impact for patients. The ultimate goal has always been to bring innovative, impactful and affordable medicine to patients. He has had success by working in Germany, US, UK, Sweden and Switzerland, but also made a number of mistakes. Quote: I am happy to share my experience and to help new entrepreneurs to pursue a career in drug discovery, at academia or industry, but ideally with novel startup companies.

Host: Kristian SandbergModerator: Anna Ridderstad

The seminar series PULSE Challenge is connected to the MSCA co-funded* postdoctoral program SciLifeLab PULSE, that will train 48 future leaders in life sciences. The program focuses on innovative, fundamental and translational research carried out in supportive and diverse academic and industrial environments, preparing postdocs with necessary skills for long-term career sustainability. Click HERE to find out more about SciLifeLab PULSE

On-line event via Zoom

Register Here

Presenter: Dr. Lorenz M. Mayr

Biography:Lorenz is working as Managing Director at BioMedTech Consulting GmbH in Basel, Switzerland. The company provides consulting service to BioPharma, Biotechnology and MedTech companies and academic institutions. He is also working as Chief Executive Officer (CEO) and Chairman of the Board (President) of PHiNE Bio AG, a new Biotech startup company in Basel, Switzerland which is operating since 08/2025 in stealth mode and financed by private investors.

Lorenz has long-lasting experience in Pharma/Biotech investments and company creation from his work at Syncona Ltd (London, UK), Hevolution Foundation (Boston, MA) and EIT-Health Gold Track (Boston, MA; Munich, Germany). Lorenz is a highly respected biopharmaceutical executive with extensive experience over the last 30 years in drug discovery, technology and innovation, business growth and financing strategy.

He has previously worked as a Chairman, Non-Executive Director, Chief Executive Officer, Chief Technology Officer, and Entrepreneur-in-Residence in the Biotech, Medtech, Pharma and Venture Capital industry across Europe and the US.

He has received first class degrees in biochemistry, biophysics, molecular & cell biology at the University of Tubingen (Germany), University of Bayreuth (Germany) and the University of Colorado at Boulder (U.S.A.) and a number of fellowships & awards for his studies in Germany and the United States.

Lorenz currently serves on the Board of Directors at Fundamental Pharma (Heidelberg, Germany), InCephalo (Basel, Switzerland) and PHiNE Bio AG (Basel, Switzerland), and serves on the Scientific Advisory Board of Fraunhofer IGB (Stuttgart, Germany), Fraunhofer IZI (Leipzig, Germany), SaxoCell (Leipzig), The Francis Crick Institute (London, UK), Science4Life (Stockholm, Sweden) SensibleBio (Oxford, UK), Hemotune (Zurich, Switzerland), Huidagene (Shanghai, China), AstraGenomics (Shanghai, China), TQ Therapeutics (Munich, Germany), GeneFab (San Francisco, CA) and NanoVation (Vancouver, Canada), and works as Senior Healthcare Advisor to EQT Investments (Stockholm/Sweden).
