SciLifeLab

Information seminar on KAW/SciLifeLab Proof of Concept call for grants 2026
2026-01-30 13:00 - 14:30 (Europe/Stockholm) | Online event via Zoom
The 4th call for KAW/SciLifeLab Proof of Concept grants in Life Science is open for applications!

The purpose of the Proof of Concept grant is to bridge the gap from academic research to innovations in life science. The grant gives researchers the opportunity to develop their early-stage discoveries towards validated methods, products or processes and provides the opportunity to carry out activities that validate and accelerate the development of the project and prepare for innovation and commercialization.

Watch the seminar below to learn more about the call. ↓

Register to the Seminar

Program

13.00The KAW/SciLifeLab Proof of Concept grants in Life Science, Olli Kallioniemi, Professor of Molecular Precision Medicine, KI, Lilian Wikström, KAW13.20Project presentation – Marie Jeansson, KITherapeutic intervention to slow progression of chronic kidney disease13.40Project presentation – Pål Stenmark, Stockholm UniversityInnovative therapeutic toxins for the treatment of neuromuscular disorders14.00Open discussionModerator – Isolde Palombo, KTH

Application period

Call opens: January 13, 2026Call closes: February 20, 2026 at 13:00

Read more about the Call

Calls for new project support in Chemical Biology and Drug Discovery
2026-01-30 12:00 - 13:00 | Online event via Zoom
The Chemical Biology Unit (CBCS) and the Drug Discovery and Development (DDD) platform at SciLifeLab have calls out for projects.

CBCS is seeking projects in Chemical Biology that include assay development for small-molecule screening and profiling, as well as enabling chemistry.

For more information, please visit www.cbcs.se.

The DDD platform is looking for new project proposals for drug discovery. All therapeutic modalities that can be developed in collaboration with the DDD platform at SciLifeLab are of interest, including small molecules, antibodies, oligonucleotides and new modalities.

Some users and projects are at the intersection between chemical biology and drug discovery. This webinar aims to guide users to the call that best suits the needs of their project

Register here!

Organizer: the Chemical Biology Consortium Sweden and the Drug Discovery & Development platform

Campus Solna Seminar Series: Woonghee Kim & Laura Steponaviciute
2026-01-29 12:00 - 13:00 | Becquerel, SciLifeLab, Tomtebodavägen 23, Solna
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Woonghee Kim

Adil Mardinoglu – alpha 6

Phospho-JNK agonists show promising effects for the treatment of hepatocellular carcinoma

Laura Steponaviciute

Simon Elsässer – alpha 4

Sense labelling in mESC for capturing dynamic proteome shifts in lineage restriction

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

Beyond Compliance: Using Data Management Plans to drive research efficiency
2026-01-28 10:00 - 11:00
A Data Management Plan (DMP) shouldn’t just be a document you file and forget to satisfy a funder. When done correctly, it serves as a vital project roadmap that prevents data loss, simplifies collaboration, and saves you weeks of tedious “data cleaning” at the end of your project.This workshop introduces the concept of data management planning as a catalyst for more efficient, high-impact research as well as a demo of the SciLifeLab Data Stewardship Wizard (DSW).

You find SciLifeLab Data Stewardship Wizard (DSW) here

There will also be time for questions and discussion. You are welcome to submit questions in advance to data-management@scilifelab.se

When: January 28th 10-11 CET Zoom (Please note that the time is 10-11 Stockholm)

Speakers: Data stewards Karin Granström and Marian Vrettou, NBIS. For the discussion sessions data stewards Katarina Öjefors Stark and Mirjam Walpot from SciLifeLab Data Centre will also join.

Register: Register before Jan 27 at 24.00

Target audience: researchers, post docs, fellows, and others interested.

Recording: https://youtu.be/nwTlWnqtN1o

For questions about the event contact SciLifeLab Data Management data-management@scilifelab.se

Register

High-Speed AFM and Cryo-EM: Dynamics and Structures of Membrane Proteins
2026-01-27 15:15 - 16:15 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Simon Scheuring

Weill Cornell Medicine, USA

Simon Scheuring is Distinguished Professor of Anesthesiology Research in the Department of Anesthesiology at Weill Cornell Medicine in New York, USA.

He is a trained biologist (Biozentrum, University of Basel, Switzerland). During his MSc and PhD, he learned electron microscopy (EM) and atomic force microscopy (AFM) for the structure determination of membrane proteins such as aquaporins and sugar transporters. During his postdoc and as research assistant (Institut Curie, Paris, France), he learned membrane physical chemistry and developed AFM for the study of native membranes and ventured into setting up his lab as a junior research director at the Institut Curie. Promoted to senior research director, he built a larger laboratory in Marseille (INSERM / Aix-Marseille Université, France). In 2017, he moved to Weill Cornell Medicine, where he got appointed as Professor in the Department of Anesthesiology (WCM, New York, USA). Simon Scheuring’s laboratory develops and applies AFM-technologies for the study of membrane phenomena, such as membrane protein structure, assembly, diffusion, and conformational dynamics of unlabeled single molecules, bridging structure and function. Over the past years, his laboratory has been instrumental in the development of High-Speed AFM (HS-AFM) methods, extracting quasi-atomic structural details from single molecule AFM data, and reaching millisecond temporal resolution for the analysis of conformational dynamics. In recent works, his laboratory combines HS-AFM with cryo-EM to acquire an integrated understanding of the dynamics and structures of membrane proteins.

Abstract

High-speed atomic force microscopy (HS-AFM) is a powerful technique that provides dynamic movies of biomolecules at work. First, I will briefly review our recent developments to break temporal limitations to characterize molecular dynamics by developing HS-AFM line scanning (HS-AFM-LS) and HS-AFM height spectroscopy (HS-AFM-HS) [1], and resolution limitations by developing Localization AFM (LAFM) [2]. Then, I will detail how we used HS-AFM to analyze membrane-embedded TRPV3 at the single-molecule level, and discovered a previously unobserved, transient, and reversible pentameric state of TRPV3, while cryo-EM analysis allowed to resolve the first structure of a pentameric TRP channel [3,4]. Finally, I will report about our most recent efforts to develop and apply 3D-AFM for the characterization of the water structure on protein surfaces [5].

References:

[1] Heath et al., Nature Communications, 2018, 9(1):4983, High-Speed AFM Height Spectroscopy (HS-AFM-HS): Microsecond dynamics of unlabeled biomolecules.

[2] Heath et al., Nature, 2021, 594(7863):385–390, doi:10.1038/s41586-021-03551-x, Localization Atomic Force Microscopy.

[3] Lansky et al., Nature, 2023, 621(7977), 206–214, doi:10.1038/s41586-023-06470-1, A pentameric TRPV3 channel with a dilated pore.

[4] Lansky et al. Nature Communications, 2025, 16(4520). https://doi.org/10.1038/s41467-025-59798-9, Structural dynamics and permeability of the TRPV3 pentamer. [5] Ma et al., submitted, 2025, Aquaporins destructure water above the pore.

Host: Stavros Azinas stavros.azinas@scilifelab.se

How to Terminate Transcription at the Right Place
2026-01-27 14:00 - 15:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Gene‑Wei Li, Associate Professor Massachusetts Institute of Technology (MIT), USA

Abstract

Precise transcription termination is essential for defining gene boundaries and achieving proper RNA output. I will discuss two recent advances regarding transcription termination in bacteria. First, we re-defined the features required for intrinsic terminators: in addition to the canonical hairpin and U-tract, two conserved sequence motifs are also necessary. This new definition quantitatively explains variations in termination efficiency and accurately pinpoints functional terminators genome-wide. Second, we showed that many bacteria have evolved purine-rich genes to avoid premature transcription termination, especially in species with “runaway transcription,” i.e., those uncoupled transcription-translation. This bias imposes strong evolutionary constraints on codon usage and the assimilation of foreign genes. Together, these principles illuminate the design principles of bacterial gene sequences and how genomes encode the correct endpoints of transcription.

Biography

Gene‑Wei Li is an Associate Professor of Biology at Massachusetts Institute of Technology (MIT) and an Investigator at Howard Hughes Medical Institute (HHMI). He earned a B.S. in Physics from National Tsinghua University (2004) and a Ph.D. in Physics from Harvard University (2010), followed by a postdoctoral fellowship at University of California, San Francisco (UCSF). His research focuses on how bacterial genomes encode quantitative control over protein production — exploring how cells optimize proteome composition through precise regulation of transcription, translation, and RNA processing.

Host; Vicente Pelechano vicent.pelechano@scilifelab.se

Metabolomics in Life Science
2026-01-27 08:00 - 2026-01-28 15:00 | Väven, Storgatan 46A, Umeå, 90326, Sweden
After the great success of the 2024 Metabolomics in Life Science conference, the Organizing Committee is thrilled to announce the second edition in 2026!Date: 27-28 January, 2026Venue: Vävenscenen, Umeå

Umeå University warmly invites you to Metabolomics in Life Science 2026, showcasing the latest NMR- and MS-based metabolomics research from Sweden, the Nordics, and beyond. The conference brings together researchers from around the world to share knowledge and discuss advances in areas like clinical and precision medicine, plant metabolomics, spatial and single-cell metabolomics, multi-omics, and computational/AI applications.

The event is organized by SciLifeLab platforms in Umeå: Swedish NMR Centre (SNC), Swedish Metabolomics Centre (SMC), and Computational Analytics Support Platform (CASP).

The program includes six keynote speakers from leading institutions, plus an industry exhibition showcasing the latest technologies and services in metabolomics research.

Registration is now open – Register here

Questions? Contact:

Ilona Dudka – ilona.dudka@umu.se

Kate Bennett – katie.bennett@umu.se

Looking forward to welcoming everyone in Umeå in January 2026!

Read more

OrganizersSwedish Metabolomics Centre (SMC)

NMR Core facility

Computational Analytics Support Platform (CASP)

[The Svedberg seminar] - How to Terminate Transcription at the Right Place
2026-01-26 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Gene‑Wei Li

Associate Professor Massachusetts Institute of Technology (MIT), USA

Bio

Gene‑Wei Li is an Associate Professor of Biology at Massachusetts Institute of Technology (MIT) and an Investigator at Howard Hughes Medical Institute (HHMI). He earned a B.S. in Physics from National Tsinghua University (2004) and a Ph.D. in Physics from Harvard University (2010), followed by a postdoctoral fellowship at University of California, San Francisco (UCSF). His research focuses on how bacterial genomes encode quantitative control over protein production — exploring how cells optimize proteome composition through precise regulation of transcription, translation, and RNA processing.

How to Terminate Transcription at the Right Place

Precise transcription termination is essential for defining gene boundaries and achieving proper RNA output. I will discuss two recent advances regarding transcription termination in bacteria. First, we re-defined the features required for intrinsic terminators: in addition to the canonical hairpin and U-tract, two conserved sequence motifs are also necessary. This new definition quantitatively explains variations in termination efficiency and accurately pinpoints functional terminators genome-wide. Second, we showed that many bacteria have evolved purine-rich genes to avoid premature transcription termination, especially in species with “runaway transcription,” i.e., those uncoupled transcription-translation. This bias imposes strong evolutionary constraints on codon usage and the assimilation of foreign genes. Together, these principles illuminate the design principles of bacterial gene sequences and how genomes encode the correct endpoints of transcription

Host: Johan Elf johan.elf@icm.uu.se UU

Genetic code reprogramming for the discovery of macrocycles for therapeutic innovation
2026-01-23 10:00 - 11:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Hiroaki Suga, Ph.D.Professor, Department of Chemistry, School of Science, The University of Tokyo

Hiroaki Suga is best known for his work on artificial ribozymes (Flexizyme) and their application in mRNA display (RaPID, random nonstandard peptide integrated discovery). He is also the founder of the very successful drug discovery company PeptiDream, Inc. He was awarded the Wolf Prize in Chemistry in 2023.

Host: David Drew, SciLifeLab

Unlocking Precision Health: From Molecular Insights to Clinical Impact in Complex Diseases
2026-01-23 09:00 - 17:00 | Operaterassen, Karl XII:s Torg, Stockholm, Sweden
The 3rd Symposium on Complex Diseases

Join us for an exciting day dedicated to advancing precision health and tackling the challenges of complex diseases. This symposium brings together leading researchers, clinicians, and industry to explore how molecular insights can transform clinical practice and improve patient outcomes.

For information about the symposium in Swedish: Unlocking Precision Health: From Molecular Insights to Clinical Impact in Complex Diseases (Swe).

Confirmed Speakers:

Oskar Frisell, Karolinska Institutet

Andrea Ganna, University of Helsinki, Finland

Lina Jonsson, University of Gothenburg

Richard Landberg, Chalmers University of Technology

Tuuli Lapalainen, KTH Royal Institute of Technology

Ruth Loos, University of Copenhagen, Denmark

Olle Melander, Lund University

Richard Rosenquist Brandell, Karolinska Institutet

Peter Würtz, Nightingale Health, Finland

Registration

Register via this form: https://forms.gle/6C7QzrzxwJ9NBPjd8. Registration deadline: 15 January 2026

Abstract Submission deadline: 5 January 2026

Program

Program symposium complex diseases Jan 23 2026_FINALDownload

Why attend?

Expand your expertise in genomics, multi-omics, and precision medicine.

Network with experts and peers across academia, healthcare, and industry.

Participate in rapid talks, poster sessions, and lively discussions.

Campus Solna Seminar Series: Leire Alonso Galicia & Alper Eroglu
2026-01-22 12:00 - 13:00 | Milkyway SciLifeLab Solna, Tomtebodavägen 23, Solna
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Leire Alonso Galicia

Joakim Lundeberg – alpha

Spatial profiling of human breast cancer

Alper Eroglu

Jean Hausser – gamma

A quest to get deep spatial transcriptomes for predicting tumor growth driving interactions

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

Mapping cells at scale: from tissue volumes to community challenges in vEM
2026-01-20 15:15 - 16:15 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Speaker: Aubrey WeigelProject Scientist, CellMap Project TeamHoward Hughes Medical Institute, Janelia Research Campus

Abstract

Large-scale, high-resolution imaging of subcellular architecture using volume electron microscopy (vEM) unlocks new opportunities for biological discovery – but realizing this potential requires more than just data acquisition. Scalable infrastructure, robust protocols, and trained personnel are critical to extract consistent insight from these complex datasets and make them useful to the broader community. The CellMap Project Team represents a coordinated effort to scale vEM-based segmentation across six dimensions: dataset scale, biological diversity, organelle classification complexity, team training, analytical depth, and open access.

Through modular training programs, systematic quality control, and block-wise processing tools, the project has grown from individual cell volumes to tissue-scale annotation across dozens of organisms and sample types. Annotated datasets are openly shared through OpenOrganelle, providing the community with immediate access to high-resolution volumes and voxel-level segmentations. To further catalyze progress in automated segmentation, we launched the CellMap Segmentation Challenge – a large-scale, open competition featuring expertly annotated training data from over 20 eFIB-SEM datasets and more than 40 unique organelle classes.

We describe how workflows and infrastructure evolved to support this scaling effort, with a focus on designing datasets that are tailored for specific biological insight yet structured for broad reuse. By scaling people, protocols, and pipelines in parallel – and committing to open data practices – the CellMap Project Team provides a model for reproducible, high-resolution cellular mapping at scale.

registration

Biography

Aubrey Weigel is currently a Project Scientist of the CellMap Project Team at HHMI – Janelia Research Campus. The team uses advanced imaging technologies to study the ultrastructure of subcellular organelles under both healthy and pathological conditions. Aubrey’s previous research background is in biophysics, with an emphasis in microscopy. Her formal training is in physics and engineering.

During her graduate work Aubrey was the co-discoverer of ergodicity breaking in cells along with Diego Krapf, driving a pivotal shift in the field of diffusion analysis in living systems. Throughout her postdoctoral career under the guidance of Jennifer Lippincott-Schwartz, she applied her training in physics and microscopy directly to answer biological questions. Here, Aubrey unraveled the underlying structure of the endoplasmic reticulum and revealed its complex dynamics. She also uncovered the nano-anatomy of early secretory compartments and discovered a new, dynamic organelle, responsible for delivering newly synthesized cargo from the endoplasmic reticulum to the Golgi.

Aubrey’s recent work as the leader of the Cell Organelle Segmentation in Electron Microscopy (COSEM) project includes developing an invaluable tool for cell biology – an analysis pipeline based on deep learning architectures for segmentation – allowing comprehensive reconstruction and analysis of organelles within entire cells imaged by volumetric electron microscopy. CellMap is now building upon this pipeline to generate, characterize, and discover how cells look in their native tissue environments – acting as a hub of collaborations that brings together scientists of different disciplines. Aubrey is committed to integrating her multi-disciplinary training into facilitating large-effort, collaborative, team projects to take on challenging scientific problems and sharing these resources with the broader scientific community.

SciLifeLab PULSE - information webinar for applicants
2025-12-18 00:00 - 23:59 | Online event via Zoom
This webinar (two time options available) gives PULSE applicants an opportunity to receive information on e.g. the matchmaking and application process, as well as eligibility rules. There will also be time for Q&A:s. Find out more about the SciLifeLab PULSE postdoc program here The 2nd SciLifeLab PULSE Call opened on December 15!

Webinar registration

Webinar on December 18, 2025, at 09:00 am, UTC+1

Register here

Webinar on December 18, 2025, at 16:00 pm, UTC+1

Register here

[Spotlight Seminar Series] The innate power of natural killer cells in cancer therapy
2025-12-16 15:15 - 16:15 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Professor Karl-Johan Malmberg (M.D. Ph.D) , Oslo University

Biography

Professor Karl-Johan Malmbergis a Specialist in Hematology with over 25 years of experience in NK cell research and cancer immunotherapy. He is the Director of a Norwegian Research Council Center of Excellence, The Precision Immunotherapy Alliance (PRIMA) and leads an international team of 20 scientists based in laboratories both at the University of Oslo, Norway and the Karolinska Institutet, Sweden. He is also the Scientific Director of the Center for Advanced Cell and Gene Therapy (ACT) at Oslo University Hospital. The group focus on deciphering basic cellular and molecular mechanisms regulating NK cell function and seek to translate insights from these efforts in the design of novel approaches for NK-cell based cancer immunotherapy against cancer.

Relevant Publications

The innate power of natural killer cells in cancer therapy.

Sohlberg E, Malmberg KJ.Nat Med. 2025 Jun;31(6):1755-1756. doi: 10.1038/s41591-025-03712-9.PMID: 40355615

Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping.

Netskar H, Pfefferle A, Goodridge JP, Sohlberg E, Dufva O, Teichmann SA, Brownlie D, Michaëlsson J, Marquardt N, Clancy T, Horowitz A, Malmberg KJ.Nat Immunol. 2024 Aug;25(8):1445-1459. doi: 10.1038/s41590-024-01884-z. Epub 2024 Jul 2.PMID: 38956379

Host: Adnane Achour adnane.achour@ki.se

[The Svedberg seminar] - Optogenetic control of gene expression dynamics in single cells
2025-12-15 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Mary Dunlop

Professor Boston University, USA

Bio

Mary Dunlop is a Professor of Biomedical Engineering and Dorf-Ebner Distinguished Faculty Fellow at Boston University. She holds additional affiliations in Bioinformatics and Molecular Biology, Cell Biology & Biochemistry. She graduated from Princeton University with a B.S.E. in Mechanical and Aerospace Engineering and a minor in Computer Science. She then received her M.S. and Ph.D. in Mechanical Engineering from the California Institute of Technology. In recognition of her outstanding research contributions, she has received many honors including election as an AIMBE Fellow, the NSF Transitions Award, ACS Synthetic Biology Young Investigator Award, DOE Early Career Award, and NSF CAREER Award. She is also the recipient of several mentoring and teaching awards, including Boston University’s Award for Excellence in Mentoring Postdocs and the College of Engineering Teaching Excellence Award.

Optogenetic control of gene expression dynamics in single cells

Emerging approaches that integrate optogenetics with feedback control are transforming our ability to precisely manipulate microbial gene expression dynamics. In this talk, I will present how we harnessed deep neural networks and model predictive control to impose real-time, cell-specific gene expression patterns in bacteria, revealing crucial links between dynamic regulation and functional outcomes such as antibiotic resistance. I will also highlight our use of optogenetic tools and information theory to understand how variable expression of a key transcription factor influences downstream stress response genes and impacts bacterial survival under antimicrobial stress. These approaches provide new insights into the significant roles of cellular heterogeneity and dynamic regulation, advancing our understanding of gene expression and microbial behavior at the single-cell level.

Host: Daniel Jones daniel.jones@icm.uu.se, UU

Science & SciLifeLab Prize Scientific Symposium 2025
2025-12-11 13:00 - 16:00 | Auditorium Stockholm, Grand Hôtel, Södra Blasieholmshamnen 8, Stockholm, 10327, Sweden
Welcome to the Scientific Symposium where the winners of the 2025 Science & SciLifeLab Prize for Young Scientists will present their research!

Science, the American Association for the Advancement of Science (AAAS), and SciLifeLab joined forces in 2013, creating the Science & SciLifeLab Prize for Young Scientists to recognize excellence amongst young researchers from around the world. A global Prize aimed at rewarding scientists at an early stage of their careers.

The Prize is awarded in four different categories and the winners will be announced on November 14th

Uche Medoh, Grand Prize Winner in Molecular Medicine

Liam Lachs, Category Winner in Ecology and Environment

Nitzan Tal, Category Winner in Genomics, Proteomics, and Systems Biology Approaches

King L. Hung, Category Winner in Cell and Molecular Biology

All four winners of the Science & SciLifeLab Prize for Young Scientists are invited to Sweden December 8-13 to participate in a unique week filled with events in honor of science. They will have the opportunity to meet with leading scientists in their field of research and create life-long connections to support their careers.

The symposium will take place at beautiful Grand Hôtel in Stockholm.

Seats are limited so register today for your chance to meet with the winners and the the AAAS/Science editor team AND our honorary guest, the Grand Prize Winner from 2024, Andrija Sente.

Registration

Program

Science SciLifeLab Prize SymposiumDownload

Read more about the Prize

Read more about the winners

Campus Solna Seminar Series: Xiangyu Li & Oskar Kviman
2025-12-11 12:00 - 13:00 | Milkyway SciLifeLab Solna, Tomtebodavägen 23, Solna
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Xiangyu Li

Adil Mardinoglu – alpha 6

Oskar Kviman

Jens Lagergren – gamma 6

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

5th annual users meeting for integrated structural biology
2025-12-11 09:00 - 16:00 | Widerströmska Huset, Tomtebodavägen 18, Solna, Sweden
We welcome you to the 5th annual users meeting for integrated structural biology!

All users, future users and researchers interested in what structural biology can bring to your project are welcome!

As previous years, the symposium is held in Solna and specifically in Widerströmska huset, Tomtebodavägen 18a, room Charles.

Read more about structural biology here: https://www.scilifelab.se/servicearea/structural-biology/

registration

Registration deadline: Sunday, December 7

Agenda

ISB_usermeeting2025_ProgramDownload

Teaching and training as "communication": leveraging cognitive and communication theories to strengthen learning
2025-12-10 10:00 - 12:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Invited speaker: Professor Rochelle E. Tractenberg, Georgetown University

SciLifeLab as a Research Infrastructure incorporates people across a variety of technically complex fields. Staff-scientists and researchers often need to communicate about their complex work to people who are not fully familiar with all the details. Swedish universities offer training or support for scientists to help them communicate complex ideas for the public. However, we don’t often consider that these communication theories and strategies might be equally useful for promoting or strengthening a learning culture across the organization or that such communication strategies are useful in the training and teaching staff-scientists and researchers are involved in. This talk by Professor Tractenberg from Georgetown University will outline two theories – one for communication and one for change management – which have been augmented with cognitive theories so that they can optimize teaching and training and with this strengthen learning.

Welcome to a seminar where Professor Rochelle Tractenberg will present her recent work combining communication with change management strategies. We will learn how we can more efficiently can promote change around complex information – such as encouraging researchers to utilize a new method or tool, or instructing students about a complex aspect of the field they’re studying.

For registrants wishing to participate online, please indicate this in the registration form. For people attending onsite there will be a light lunch provided after the seminar.

Register here

Scientific abstract

Tractenberg’s augmented Diffusion of Innovation (aDOI, Tractenberg, 2023) is a theoretical framework for understanding and leveraging the cognitive complexity of messages so as to optimize uptake of the new information by any hearer. aDOI is adapted, through cognitive theory, from Rogers’ DOI communication model (1965/2003). A concrete, stepwise theory of change management (ToCM, Kotter 2012) originated in business, and has been widely used across business and leadership programs. This theory has also been augmented with cognitive theory (aToCM, Tractenberg 2024). Together, these two revised models provide a strategy for promoting change around complex information – such as encouraging scientists to utilize a new method or tool, or educating students about a complex aspect of the field they’re studying. Tractenberg’s augmented Diffusion of Innovation and Theory of Change Management make encouraging uptake of new ideas, or new knowledge, more consistent with human reasoning. These can support instructors’ adaptation of existing courses to include new information/technology or techniques, and can also help instructors to learn new evidence-based methods of teaching and assessing.

[The Svedberg seminar] - The origins of locally adaptive loci
2025-12-08 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Gabriela Montejo-Kovacevich

Assistant Professor SciLifeLab Fellow Uppsala University

Bio

Gabriela Montejo-Kovacevich is a SciLifeLab fellow and Assistant Professor that recently established her lab at the Animal Ecology program in the Department of Ecology and Genetics at EBC (Uppsala University). Her group studies mechanisms that promote or constrain local adaptation. By integrating genomics with ecological and natural history approaches, mainly in insects, they explore the mode and tempo of evolution in natural populations.

The origins of locally adaptive lociHow do organisms evolve to inhabit diverse environments? This seminar explores the mode and tempo of evolution in the wild by studying local adaptation in three insect systems. I will first present work on Heliconius butterflies along a 1500m altitudinal gradient in the Andes, revealing strong, repeated selection at high-altitude, with evidence for adaptive introgression from pre-adapted species. I will then turn to a ‘megapest’ moth (Helicoverpa) that is threatening food security in Brazil through bidirectional adaptive introgression conferring insecticide resistance. Finally, I will introduce Euphydryas editha, a Californian butterfly capable of rapid, heritable shifts in host plant use offering a rare glimpse into ongoing behavioural adaptation to anthropogenic change. Together, these systems demonstrate how evolutionary forces interact to shape resilience in a rapidly changing world.

Host: Göran Arnqvist Goran.Arnqvist@ebc.uu.se, UU

Discovery and developmentof GRK2-biased beta 2-adrenergic receptor agonists for the treatment of metabolic disorders
2025-12-05 10:15 - 11:00 | BMC Room C4:301, Husargatan 3, entrance C1, Uppsala, Sweden
Presenter: Dr Benjamin Pelcman, Atrogi AB

Atrogi AB is biotech company pioneering first-in-class treatments to revolutionize metabolic health. The talk will describe how targeting a novel GRK-biased b2-adrenergic receptor signaling pathway allows for the successful design of compounds useful in the treatment of disorders like type 2 diabetes (T2D), obesity and muscular wasting. The approach will be exemplified by the invention, selection and development of ATR-258, a b2-AR agonist that was developed for T2D and is about to enter phase 2 clinical trials. During the exploration of the chemical space, a diverse set of molecules were synthesized, and their effect on the downstream signaling will be discussed. In addition, the seminar will illustrate differences between drug development in Big Pharma and small biotech and the challenges of working in an environment with limited resources.

After receiving his Ph.D. in Organic Chemistry at KTH and a post doc session at Dartmouth College, NH, USA, Benjamin joined Astra Pain Control, first in Södertälje and then in Montreal, as a medicinal chemist. Benjamin has also held various positions at Pharmacia & Upjohn, Karo Bio, Biolipox and Orexo. After having started his own consultancy company, BeePCo, he came in contact with Atrogi where he was employed first as a CEO and later as Head of Chemistry and IP. Benjamin is now retired but is still working as a consultant for Atrogi and other small biotechs.

Campus Solna Seminar Series: Nona Struyf & Iva Sutevski
2025-12-04 12:00 - 13:00 | Air&Fire, SciLifeLab Stockholm, Tomtebodavägen 23A, Solna, Sweden
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Nona Struyf

Brinton Seashore-Ludlow – alpha 4

FLT3 inhibitor response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics

Iva Sutevski

Burcu Ayoglu – gamma 3

Leveraging spatial proteomics for molecular and single-cell insights into neurodegenerative diseases

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.

3D Imaging in Health and Disease
2025-12-04 09:00 - 17:00 | Nobel Forum, Nobels väg 1, Solna, Sweden
Characterizing molecular and cellular complexities in 3D is an emerging field allowing to study biology in its true context.

In this symposium national and international experts will present developments and applications in 3D imaging aimed to improve health and disease analysis across scales

Please register by sending an e-mail to hans.blom@scilifelb.se

Program 3D symposiumDownload

User meeting for your multi-modal research projects
2025-12-04 09:00 - 10:30 | virtual event
Boost your research — Book a private SciLifeLab planning and feedback session for your multi-modal research projects!

Register here

Once we have received your registration, you will be sent the link to the online meeting.

Date: December 4, 9.00 – 10.30 Registration deadline: November 28

Multimodal molecular profiling and novel computational methods are transforming life science research, but also pose new challenges in study design, project resource planning and data management. SciLifeLab is a national resource of unique technologies and expertise available to life scientists, in areas such as biomedicine, ecology and evolution, aiming to bring scientists together across traditional boundaries and foster collaborations with industry, health care, public research organizations and international partners.

The first Thursday of every month at 9.00 (except July and August), SciLifeLab offers an opportunity to jointly meet with representatives across the SciLifeLab service platforms, to get feedback and help to plan, design, and refine new or ongoing multimodal research projects. Your project plans are discussed privately and remain confidential, and information will not be shared outside of the service platforms. Note that for most studies, follow-up meetings will be needed, but our aim for these meetings is to provide an easy-access entry point for an overarching planning of multimodal studies.

For studies focusing on a single technology only, please primarily contact our service platforms directly as described at the SciLifeLab homepage.

To make the best out of the allotted time, we ask you to provide some background information about your project, to help us ensure that the relevant experts are available to discuss your study.

The NIH NIAID Blueprint: A FAIR Implementation Approach for the Biomedical Sciences
2025-12-03 16:30 - 17:30 | Online event via Zoom
SciLifeLab Data Centre welcome you to join us for the webinar “The NIH NIAID Blueprint: A FAIR Implementation Approach for the Biomedical Sciences” presented by Christine Kirkpatrick. Head – GO FAIR US, Secretary General – CODATA, Principal Investigator – NIAID Data Landscaping and FAIRification, San Diego Supercomputer Center, UC San Diego

When: Wednesday Dec 3, 16:30-17:30 CET (Zoom)

register here

As organisations adopt the FAIR Principles, many face challenges FAIRifying not just datasets but entire ecosystems. The National Institute of Allergy and Infectious Diseases (NIAID), an Institute within the US National Institutes of Health (NIH), manages a diverse data landscape across infectious, allergic, and immunologic domains.

Its FAIRification project aims to improve discovery and reuse across repositories with varied architectures, metadata maturity, and timelines. This work culminated in the recently released, “A Blueprint for Including Digital Objects in the NIAID Data Ecosystem.

This presentation describes the GO FAIR US–led assessment of NIAID repositories, highlighting:

Customized FAIR assessment instruments

Evaluation of record-based (not just file-based) repositories

Common assessment and progress tracking

Impact-driven adoption of metadata standards and PIDs

Improving citation practices

Adapting to social and project constraints

The approach builds on prior FAIR frameworks (FAIRsFAIR, RDA DMM, EarthCube, GO FAIR Foundation) and uses stakeholder-informed questionnaires and interviews to capture repository practices. Combining qualitative assessment and FAIR Implementation Profiles, the method establishes a FAIR baseline, guides targeted improvement strategies, and enables cross-repository comparison to inform strategic planning and strengthen community buy-in.

Organiser: SciLifeLab Data Centre For more information or inquiries please contact: datacentre@scilifelab.se

This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. 75N91019D00024. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

Is high-throughput electrophysiology possible?
2025-12-02 13:00 - 14:00
Register here

On site seminar – Electrophysiology Infrastructure

Location: Jörgen Lehmann, Academicum, Medicinaregatan 3 and SciLifeLab Gothenburg

Presenters

Fredrik Elinder, Professor, Site director SciLifeLab Linköping, Chemical Biology Consortium Sweden (CBCS), and Department of Biomedical and Clinical Sciences (BKV), Linköping University

Nina Ottosson, Research Coordinator, Chemical Biology Consortium Sweden (CBCS), and Department of Biomedical and Clinical Sciences (BKV), Linköping University

The electrophysiology unit at Linköping University, part of Chemical Biology Consortium Sweden (CBCS) at SciLifeLab, visits site Gothenburg, and presents the infrastructure during a seminar.

During the day, 1-on-1 meetings with the presenters will be possible at The SciLifeLab office, Medicinaregatan 3. Take the chance to discuss how your research questions can be answered through analyses of ion channels. Request is added in the registration form.

The electrophysiology unit, a recent addition to SciLifeLab’s range of infrastructures, is equipped with automated patch-clamp instrumentation, and supports a wide range of electrophysiological studies involving both voltage-gated and ligand-gated ion channels, including pharmacological screening, cardiac safety assessments, and biophysical investigations.

WELCOME!

Fredrik Elinder and Nina Ottosson, Electrophysiologists

Josefine Sandström and Maria Smedh, SciLifeLab site coordinators Webpage of the CBCS Linköping node.

Introduction to the Module System on Berzelius
2025-12-02 10:00 - 11:30 | Zoom
This training offers a practical introduction to the module system on Berzelius. The session will cover:

how to find modules on Berzelius

load/unload modules

use modules in interactive or batch modes

create your own module

Participants will also gain hands-on experience with these commands. By the end of the session, you will be able to navigate the modules system Berzelius confidently and use them effectively for your research.-on experience with these commands. By the end of the session, you will be able to navigate Berzelius confidently and use its resources effectively for your research.

Date: December 2, 2025Time: 10:00–11:30

Target audience: The online event is open for all current and prospective Berzelius users. Please read the eligibility requirements for accessing Berzelius.Place: Online via Zoom (link provided upon registration)

registration

Preliminary Agenda

TimeSession TitleSpeaker(s)10:00–11:00Introduction to the Module System on BerzeliusSoumi Chaki11:00–11:30Open Q&A SessionBerzelius Application Expert

This event is a collaboration between National Supercomputer Centre (NSC) at Linköping University and SciLifeLab Data Centre.

For questions please contact soumi.chaki@liu.se (Soumi Chaki)

[The Svedberg seminar] - Genome organisation and patterns of molecular evolution
2025-12-01 15:15 - 16:15 | BMC Room C8:301, Husargatan 3, Uppsala, Sweden
Jennifer James

Assistant Professor DDLS Fellow

Bio

Dr. Jennifer James did her PhD in population genetics with Adam Eyre-Walker at the University of Sussex. After a postdoctoral position at the University of Cambridge she moved to the US, where she worked as a postdoctoral researcher with Joanna Masel at the University of Arizona, which introduced her to the world of proteomics. She next moved to Uppsala and worked as a postdoctoral research fellow with Martin Lascoux prior to becoming a DDLS fellow and starting her own new research group in Molecular Evolution. Her group conducts research on patterns of molecular evolution both at the genome and proteome level, with a focus on understanding mutational robustness.

Genome organisation and patterns of molecular evolution

In my group, we try to understand patterns of phenotypic evolution at the proteome level, and molecular evolution across the genome. Key to this question is understanding how the genome is structured and organised. For example, how pleiotropic are the effects of genes on average, and how complex are gene networks? To give one case, if pleiotropy is universal, such that all genes affect all traits, we expect all new mutations to have the same effect on fitness. However, the extent of pleiotropy in real biological systems remains debated. In this seminar I will discuss our

Host: Siv Andersson siv.andersson@icm.uu.se, UU

Multimodal explorative testing in the ON-OFF ibrutinib trial in CLL
2025-11-28 09:00 - 09:30 | Online event via Zoom
Multimodal explorative testing in the ON-OFF ibrutinib trial in CLLRichard Rosenquist Brandell, Karolinska Institutet & Karolinska University Hospital

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western World and displays substantial variability in clinical course, ranging from indolent disease requiring no therapy to highly aggressive forms with short survival despite treatment. Although the past decade has seen major advances in drug development, CLL remains incurable. Targeted therapies, particularly Bruton’s tyrosine kinase inhibitors (BTKi), have become central to CLL management. However, continuous long-term BTKi administration, such as with ibrutinib, is associated with considerable significant side-effects, including cardiac arrhythmias. Furthermore, despite its proven efficacy in both treatment-naïve and relapsed/refractory CLL, resistance to ibrutinib continues to challenge durable disease control. To address these limitations, we conducted a phase 1b/2 prospective, single-arm, multicenter study evaluating controlled treatment cessation as a strategy to preserve tolerability and maintain sensitivity to ibrutinib, while also improving cost-effectiveness. The study protocol incorporated serial blood sampling prior to treatment initiation and throughout on/off treatment periods. Here, we leverage this unique longitudinal sample collection to perform multimodal profiling, including genomic and transcriptomic sequencing as well as proteomics, to investigate mechanisms of drug response and resistance. We provide an update on the current status of the study and ongoing analyses.

registration

Biography

Richard Rosenquist Brandell is Professor of Clinical Genetics at the Department of Molecular Medicine and Surgery, Karolinska Institutet, and Senior Physician in Clinical Genetics at Karolinska University Hospital, Sweden. Focusing on hematological malignancies and utilizing high-throughput sequencing and other innovative technologies, his research team has identified novel prognostic and predictive biomarkers that have refined disease classification and significantly improved patient risk-stratification and clinical decision-making. Richard Rosenquist Brandell initiated and led the Clinical Genomics Unit within Science for Life Laboratory (SciLifeLab) in Uppsala (2013-2017) and was platform director for the Clinical Genomics platform (2016-2021) within SciLifeLab, which includes seven Clinical Genomics units across Sweden. He is currently Director of Genomic Medicine Sweden (GMS), a national infrastructure for implementation of precision medicine. Rosenquist Brandell is a member of the Nobel Assembly at Karolinska Institutet.

Campus Solna Seminar Series: Koen Jurgens & Alana Panzenhagen
2025-11-27 12:00 - 13:00 | Milkyway SciLifeLab Solna, Tomtebodavägen 23, Solna
Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively), with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged.

The seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar.

PhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester.

This week:

Koen Jurgens

Marta Carroni – gamma 6

Structural basis for p97 and ataxin-3 interplay

Alana Panzenhagen

Ola Larsson – gamma 5

Uncovering mechanisms and organization underlying selective regulation of mRNA translation

This seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
