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DTSTART;TZID=Europe/Stockholm:20220509T151500
DTEND;TZID=Europe/Stockholm:20220509T160000
DTSTAMP:20260404T124212
CREATED:20220502T101150Z
LAST-MODIFIED:20220502T101852Z
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SUMMARY:The Svedberg seminar: Daniel Fürth
DESCRIPTION:Assistent Professor\, SciLifeLab Fellow at Uppsala University \n\n\n\nHybrid event: Trippelrummet\, Navet\, BMC and Online \n\n\n\n\n\n\n\n\n\nRegister here\n\n\n\nDr. Daniel Fürth completed his Ph.D. in neuroscience at Karolinska Institutet\, working on mesoscale connectomics using modified rabies virus tracing\, then postdoctoral work in RNA biology and method development at Cold Spring Harbor Laboratory\, Cancer Center\, New York. At Cold Spring Harbor he focused on enabling functional RNA genomics in situ at subcellular single-molecule resolution. Dr. Fürth’s expertise as a leader in both wet and dry lab neuroscience is internationally recognized with a Brain & Behavior Research Foundation NARSAD Young Investigator Award and computational funding from the Chan Zuckerberg Initiative. Dr. Fürth’s lab studies how information is stored\, processed and transmitted between cells. The focus is to find hitherto unknown mechanisms that can transfer symbolic information between cells. Identification of such transmission would enable us to read and write those messages.  \n\n\n\nTitle of the seminar: From in situ to in vivo sequencing\n\n\n\nUnbiased investigation of subcellular RNA localization and its control in vivo remains challenging. Current hybridization-based methods cannot differentiate small regulatory variants\, whilein situ sequencing is limited by short reads. We solved these problems using a bidirectional sequencing chemistry to efficiently image transcript-specific barcodes in situ\, which are then extracted and assembled into longer reads using NGS. Specific cis-regulatory elements usually found in mRNA 3′UTRs mediate RNA localization. Reverse transcription was primed towards the 3’UTR/polyA-tail junction in developing Drosophila and we discovered that in situ cDNA synthesis stalls just downstream of RNA-binding protein crosslink sites\, resulting in truncated cDNAs near RNA-binding protein motifs. We utilized these stop signatures to spatially map cis-regulatory motifs in specific alternative polyadenylation (APA) isoforms. A subset of genes displayed expression of two or more APA isoforms with distinct localization in situ\, to which we could identify their putative trans-acting partners. We validated our findings using both iCLIP-seq and targeted clampFISH probes. Our platform\, therefore\, provides a powerful way to discover novel RNA variants and protein interactions and their localization in situ. Lastly\, I’ll present recent developments of a fluorogenic and non-enzymatic sequencing chemistry capable of sequencing single molecules directly in live cells with subcellular precision.
URL:https://www.scilifelab.se/event/the-svedberg-seminar-daniel-furth/
LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/Picture1-The-Svedberg-edited.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220510T084500
DTEND;TZID=Europe/Stockholm:20220510T170000
DTSTAMP:20260404T124212
CREATED:20220428T081405Z
LAST-MODIFIED:20220428T092504Z
UID:10000596-1652172300-1652202000@www.scilifelab.se
SUMMARY:Spatial and Single Cell Biology Platform Retreat
DESCRIPTION:Welcome to this meeting for the Spatial and Single Cell Biology Platform. Please note that this is an internal event for staff and members of the SSCB platform management group and invited members of the associated research groups of the SSCB Platform Scientific Directors. \n\n\n\nSign up here if you are an sSCB platform Employee\n\n\n\n\n\n\n\nProgram\n\n\n\n8:45 – 9.00 Coffee and registration \n\n\n\n9.00 – 9.20 Welcome and short introduction of platform (Charlotte/Mats) \n\n\n\nHU/PI presentation (≈10+10 min interactive presentations/discussion) \n\n\n\n9.20 – 9:40 PI/HU presentation 1 – In situ sequencing/Nilsson Lab \n\n\n\n9.40 – 10.00 PI presentation 2 – Spatial Proteomics/Lundberg Lab \n\n\n\n10.00- 10.20 PI presentation 3 – Spatial Transcriptomics/Lundeberg Lab \n\n\n\n10:20 – 10.40 PI presentation 4 – Advanced FISH Technologies/Bienko Lab \n\n\n\n10.40 – 11.40 Round tour of units \n\n\n\n11:40 – 12:30 Lunch and networking in Gamma 2 Lobby \n\n\n\n12.45 – 13.10 PI presentation 5 – Spatial Mass Spectrometry/ Andrén Lab \n\n\n\n13.10 – 13.30 PI presentation 6 – Eukaryotic sc genomics/Sandberg Lab \n\n\n\n13:40 – 15.00 Platform operation discussions/questions in groups of ≈ 5 in small meeting rooms ( \n\n\n\nFrom 13.30 Coffee and fika to bring to the small group discussions \n\n\n\nFocus on topics that involve everyone and not only the HU: \n\n\n\nHow to work closer together?Biggest challenges?Workflow from project start to delivery. How divide tasks within the team?User fee models? How to charge customer?How to prioritize projects?Queue?Unit Cross-over projects?\n\n\n\n15:00 – 16:30 Mingle with drinks and snacks and PI driven Panel discussion (whole group) – (Mats) \n\n\n\nLooking forward to see you all on May 10!
URL:https://www.scilifelab.se/event/sscb-platform-retreat/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ORGANIZER;CN="SSCB Platform":MAILTO:charlotte.stadler@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220510T110000
DTEND;TZID=Europe/Stockholm:20220510T113000
DTSTAMP:20260404T124212
CREATED:20220505T144221Z
LAST-MODIFIED:20220505T145612Z
UID:10000602-1652180400-1652182200@www.scilifelab.se
SUMMARY:SciLifeLab Uppsala PhD&Postdoc seminar
DESCRIPTION:Welcome to SciLifeLab Uppsala PhD&Postdoc seminars! \n\n\n\nWe are very happy to host exciting talks by PhD students and Postdocs from a great variety of fields within SciLifeLab. \n\n\n\nSpeaker: Jinlin Li\, Researcher at the Heparan Sulfate Biology group (Jinlin Li’s lab)\, Dept. of Medical Biochemistry and MicrobiologyTitle: Heparanase attenuates ZIKV infection by impeding the stability of viral protein \n\n\n\nSummary: Heparanase (Hpa) is the only endoglycosidase enzyme in mammalian cells capable of cleaving heparan sulfate. In addition to the well-known functions in the regulation of glycosaminoglycans integrity\, accumulating evidence indicate Hpa plays vital roles in virus infection\, while the mechanisms are not yet fully understood\, especially in RNA virus infection. In this study\, we found Zika virus (ZIKV) reduced the expression of Hpa at the late life cycle of viral infection. Overexpression of wild-type Hpa but not the inactive enzymatic mutant (Hpa-DM) in Huh7 cells dramatically decreased the production of infectious virions. These findings were further confirmed by the results from Mouse Embryonic Fibroblasts (MEF) cells that knock-out of Hpa enhanced ZIKV production\, while overexpression of Hpa suppressed the production of virions. Further investigations indicated that overexpression of Hpa in Huh7 cells exhibited no obvious effects on ZIKV’s attachment/entry and replication steps\, but resulted in a significant downregulation of ZIKV envelope protein (E). Hpa was also shown to specifically degrade E protein when performed co-transfection of plasmids encoding Hpa and viral proteins in HEK-293T cells. Altogether\, our study discovered an unrecognized role of Hpa in virus infection and demonstrated that Hpa serves as a restriction factor for ZIKV infection.
URL:https://www.scilifelab.se/event/campus-uppsala-phd-postdoc-seminars/
LOCATION:Online event via Zoom
CATEGORIES:Community
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/05/SciLifeLab-PhDPostdoc-conuncil-poster_landscape_May_10.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220510T120000
DTEND;TZID=Europe/Stockholm:20220510T130000
DTSTAMP:20260404T124212
CREATED:20220428T075520Z
LAST-MODIFIED:20220428T075524Z
UID:10000595-1652184000-1652187600@www.scilifelab.se
SUMMARY:National NMR Infrastructure at KBC. What can we do for you?
DESCRIPTION:In the frame of the “SciLifeLab Site Umeå / KBC Infrastructure Seminar Series”\, the seminars will be organised every second Tuesday during spring 2022 in turn with IceLab Lunch Pitches. The seminars will be held in a hybrid format IRL in Glasburen\, KBC\, and online via Zoom. Take the chance to get information on facilities\, possibilities and services that infrastructure\, both SciLifeLab-associated and local\, can offer! Learn more about the seminar series and Schedule for Spring 2022 here. \n\n\n\nOn May 10th\, 12:00-13:00\, SciLifeLab Site Umeå / KBC Infrastructure Seminar Series presents:  \n\n\n\n“National NMR Infrastructure at KBC. What can we do for you?” \n\n\n\nby Gerhard Gröbner\, Platform Director\, Professor\, Department of Chemistry\, Umeå University andJürgen Schleucher\, Platform Director\, Professor\, Department of Medical Biochemistry and Biophysics\, Umeå University \n\n\n\nSeminar description: The KBC based central NMR facility(Homepage) provides access to one of the most powerful liquid and solid-state NMR infrastructures in the Nordic countries and expertise for all researchers in the KBC and Campus environment. The facility serves large user groups spanning a remarkably wide range of fields\, such as materials science\, chemical biology\, organic synthesis\, structural biology\, plant- and environmental sciences\, biogeochemistry and medical metabolomics. Local researchers profit strongly from the facility’s status as a national infrastructure and different structural biology facilities and expertise (“Integrated Structure Biology”) at UMU. Fragment-based screening is also offered as national support in collaboration with CBCS/LCBU\, including comprehensive substance libraries. The facility is also closely linked to large research initiatives at the campus such as MIMS\, UCMP\, Bio4Energy\, UPSC\, the Swedish Metabolomics Center (SMC) and with SLU through collaborations and by offering service. \n\n\n\nActivities: If required\, a short guided tour to the NMR facility and drop-in discussions with NMR people about potential projects could be organised after the seminar. \n\n\n\nRegistration: \n\n\n\nSign up (latest by May 9th\, 10 a.m.) for on-site attendance to reserve your free lunch sandwich: \n\n\n\nor follow online via Zoom (registration is not required): https://umu.zoom.us/j/63138997026 . \n\n\n\nOrganisers: SciLifeLab Site Umeå and Chemical Biological Centre (KBC)
URL:https://www.scilifelab.se/event/national-nmr-infrastructure-at-kbc-what-can-we-do-for-you/
LOCATION:Glasburen Seminar Room\, Chemical Biological Centre (KBC) Building\, Umeå University\, Umeå\, 901 87\, Sweden
CATEGORIES:Event
ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220510T120000
DTEND;TZID=Europe/Stockholm:20220513T160000
DTSTAMP:20260404T124212
CREATED:20220224T125406Z
LAST-MODIFIED:20220302T073938Z
UID:10000536-1652184000-1652457600@www.scilifelab.se
SUMMARY:Nordic ELIXIR-GOBLET Train-the-Trainer - Online
DESCRIPTION:This course offers guidance\, ideas and tips for designing training/teaching\, development and delivery on training activities\, all based on research-driven educational principles. This course will cover 4 main topics: \n\n\n\nLearning principles and how they apply to training and teachingDesign and plan session\, course\, materialsTeaching techniques to enhance learner engagement and participationAssessment and feedback in training and teaching\n\n\n\n\n\n\n\nNote! The course is highly interactive and hence it is important that you\, as a participant\, actively contribute to all sessions and elements of the course \n\n\n\nThis course will be delivered through Canvas learning management system.  \n\n\n\nCourse Time: 12:00 – 16:00 CETCourse Format: Online via Zoom and it will include breakout sessions \n\n\n\n\n\n\n\nContact\n\n\n\nFor queries\, please don’t hesitate to contact us at education@nbis.se \n\n\n\n\n\n\n\n\nCOURSE WEBSITE AND PROGRAM\n\n\n\nREGISTRATION\n\n\n\n\n\n\n\n\nDeadline for applying to the course is 3rd of April. You will receive notification regarding acceptance to the course or if you are on the reserve list no later than one week after the closing of the registration. \n\n\n\n\n\n\n\nCourse fee\n\n\n\nThere is no course attendance fee. \n\n\n\nNote! If you are accepted and decide not to attend without communicating the reason for the no-show with us\, we will invoice a no-show-fee of 200 Euros. \n\n\n\nThe invoicing information needs to be included in the registration in order to guarantee your spot in the training event\, if you are to be accepted. By giving the invoice information you hereby confirm that the group leader/PI/manager has given a consent regarding your possible participation in the Training event. NOTE – Uppsala University cannot invoice individuals. \n\n\n\n\n\n\n\nCourse content\n\n\n\nLearning Objectives: \n\n\n\nTo get acquainted with Learning principles and how they apply to trainingTo be able to select and use training techniques that can help enhance learner engagement and participationTo learn how to use assessment and feedback in trainingTo learn about session\, course\, and materials design\n\n\n\nLearning Outcome: \n\n\n\nBy the end of this course\, learners will be able to: \n\n\n\nName learning principles that a good teacher/instructor should have in mindDescribe at least three training techniques\, drawing on learning principlesDesign a training session and a courseDevelop assessment questionnairesEnumerate types of materials needed for each part of a training session or course\n\n\n\n\n\n\n\nTarget audience\n\n\n\nWhoever is interested in becoming a trainer/instructor\, or improving your training skills. If you have questions like the following ones\, this course may be very helpful to you. \n\n\n\nHow learning works?How do I use learning principles and theories to improve my teaching/training?How do I make my teaching/training more engaging and effective?How should I adjust my teaching/training to different types of learners?How do I ensure learning progress?How can I assess whether my students are actually understanding my lessons? Are they actually learning?What is the best balance between theory and practice?How can I best assess whether learning is occurring and/or has occurred?What works in a classroom and what doesn’t?\n\n\n\n\n\n\n\nSelection criteria\n\n\n\nWe will accept a maximum of 20 participants. Priority will be given to applicants from institutes and organisations across the Nordic research community and to participants from Nordic ELIXIR nodes. \n\n\n\n\n\n\n\nCourse team\n\n\n\nInstructors: \n\n\n\nJessica Lindvall (ELIXIR-SE Training Coordinator\, NBIS\, Sweden \n\n\n\nNina Norgren (ELIXIR-SE\, Training Coordinator\, NBIS\, Sweden) \n\n\n\nNazeefa Fatima (ELIXIR-NO\, Data Steward\, UiO\, Norway) \n\n\n\nErik Hjerde (ELIXIR-NO\, Training Coordinator\, UiT\, Norway) \n\n\n\nPriit Adler (ELIXIR-EE\, Trainer\, UT\, Estonia) \n\n\n\nAllegra Via (ELIXIR-IT\, Training Coordinator\, IBPM-CNR\, IT) \n\n\n\nPatricia Palagi (ELIXIR-CH\, Training coordinator\, SIB) \n\n\n\nOrganisers: \n\n\n\nELIXIR-SE \n\n\n\nELIXIR-NO \n\n\n\nELIXIR-FI \n\n\n\nELIXIR-EE
URL:https://www.scilifelab.se/event/nordic-elixir-goblet-train-the-trainer-online/
LOCATION:Online event via Zoom
CATEGORIES:Course
ORGANIZER;CN="NBIS - National Bioinformatics Infrastructure Sweden":MAILTO:education@nbis.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220511T110000
DTEND;TZID=Europe/Stockholm:20220511T160000
DTSTAMP:20260404T124212
CREATED:20220425T081942Z
LAST-MODIFIED:20220427T142909Z
UID:10000593-1652266800-1652284800@www.scilifelab.se
SUMMARY:Spatial Biology Tour
DESCRIPTION:The Spatial proteomics unit together with Lunaphore invite you to a workshop to learn about their new instrument and service with the COMET platform. The Spatial proteomics unit is the first lab in Sweden to offer multiplexed protein detection with the COMET platform\, which relies on sequential indirect immunofluorescence using off the shelf primary antibodies. The workshop also allows for a guideed tour of the lab and an instrument demonstration. Lunch will be served for registered participants.  \n\n\n\nplease sign up here to attend
URL:https://www.scilifelab.se/event/spatial-biology-tour/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
ORGANIZER;CN="Spatial Proteomics Unit":MAILTO:spatial.proteomics@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220511T140000
DTEND;TZID=Europe/Stockholm:20220511T153000
DTSTAMP:20260404T124212
CREATED:20220426T132422Z
LAST-MODIFIED:20220507T113616Z
UID:10000594-1652277600-1652283000@www.scilifelab.se
SUMMARY:Decoding the development of the human spinal cord by multi-omics
DESCRIPTION:Decoding the development of the human spinal cord by multi-omics \n\n\n\nXiaofei Li and Erik Sundström \n\n\n\nHDCA Seminar Series 2022 | Spinal cord \n\n\n\nThe human spinal cord has highly diverse cell types\, which are generated during development\, governed by a series of temporal and spatial events for proper spinal cord assembly and function. However\, the molecular regulation of cell fate specification in the human developing spinal cord remains largely unknown. Here\, by performing single-cell RNA sequencing\, spatial transcriptomics and in situ sequencing\, we integrate the datasets and provide a comprehensive single-cell and spatial transcriptomic atlas of the developing human spinal cord of the first trimester\, from postconceptional week 5 to 12. We observe that all major cell populations in human adult spinal cord have been specified within the first trimester with abundant cell states\, and identify the key genes associated with cell fate choices and their spatial expression. Unexpectedly\, we find that during early cell fate specification\, many human neural progenitor cells have lost their self-renewal capacity. Further the the expression of gliogensis genes is much higher in human compared to the correspondent rodents at the early stage\, suggesting earlier gliogenesis in human. Finally\, we demonstrate how to use our developmental map for molecular cues that direct sequential cellular differentiation and define cells and locations associated to both normal development and spinal cord diseases. \n\n\n\nsign up to attend\n\n\n\nPlease register also if you want to participate in the digital broadcast. The Zoom link will be sent out through the registration system.  \n\n\n\n– \n\n\n\nHuman developmental cell atlas (HDCA) is the Swedish effort within the human cell atlas (HCA)\, one of the largest international scientific projects. The project aim is to create a comprehensive molecular atlas of human prenatal development at the molecular resolution using state-of-the-art multi-omic technologies such as single-cell RNA-seq\, Spatial Transcriptomics\, in situ sequencing in order to provide deeper insight into how variations and deviations contribute to health and disease. \n\n\n\nThe HDCA Seminar Series 2022 invites you to join us on a journey of early human organogenesis of several organs at the single-cell and spatial resolution. Seminars will be held at SciLifeLab Gamma building on Wednesdays at 14:00 or 15:00 and also via Zoom. After each seminar\, we will have up to 30 min round up discussions with the speaker on how you can contribute to the atlas! \n\n\n\nWarm Welcome!
URL:https://www.scilifelab.se/event/decoding-the-development-of-the-human-spinal-cord-by-multi-omics/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/hdca_logo.png
ORGANIZER;CN="The Human Developmental Cell Atlas":MAILTO:hdca-sweden@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220511T141500
DTEND;TZID=Europe/Stockholm:20220511T154500
DTSTAMP:20260404T124212
CREATED:20220502T110248Z
LAST-MODIFIED:20220504T075959Z
UID:10000599-1652278500-1652283900@www.scilifelab.se
SUMMARY:SciLifeLab COVID-19 seminar: Lilly Schwieler and Elham Rostami
DESCRIPTION:Topic: Neurological implication of COVID \n\n\n\nThe third SciLifeLab COVID-19 seminar this spring starts with Lilly Schwieler\, Associate Professor\, Physiology and Pharmacology\, Karolinska Institutet\,talking about Peripheral and central levels of kynurenine metabolites in COVID-19 patients. Elham Rostami\, Associate Professor\, Neurosurgery\, Uppsala university\,then continues the seminar with her talk on COVID19 and neurological complication. \n\n\n\nSchedule\n\n\n\n14:15-15:00Peripheral and central levels of kynurenine metabolites in COVID-19 patients.Lilly Schwieler\, Associate Professor\, Physiology and Pharmacology\, Karolinska Institutet15:00-15:45COVID19 and neurological complicationElham Rostami\, Associate Professor\, Neurosurgery\, Uppsala University\n\n\n\n\n\n\n\nRegistration is mandatory to get the Zoom link for the event  \n\n\n\n\nREGISTRATION\n\n\n\nBIOS & ABSTRACTS
URL:https://www.scilifelab.se/event/scilifelab-covid-19-seminar-lilly-schwieler-and-elham-rostami/
LOCATION:Online event via Zoom
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220516T080000
DTEND;TZID=Europe/Stockholm:20220517T170000
DTSTAMP:20260404T124212
CREATED:20220309T093342Z
LAST-MODIFIED:20220512T143421Z
UID:10000548-1652688000-1652806800@www.scilifelab.se
SUMMARY:Planetary Biology Workshop
DESCRIPTION:EMBL-SciLifeLab workshop on the theme Planetary Biology \n\n\n\nThe purpose of the workshop is to enhance connectivity between researchers at both\, SciLifeLab and EMBL\, to identify new collaboration ideas\, and to promote joint technology and infrastructure resource development within Planetary Biology. \n\n\n\nThis is one of many workshops that will follow the conclusion of the MoU between SciLifeLab and EMBL in 2021. \n\n\n\nThe workshop is a hybrid event. Physical location is the EMBL Heidelberg campus\, where in-person attendance is limited. Allocation of spaces is on a first-come first-served basis.  \n\n\n\nPlease note: there are two separate registration links for on-site or virtual participation. In case you sign up for on-site participation but your availability changes\, please make sure to inform the responsible contacts. \n\n\n\nThe workshop will include talks on a broad set of themes including: \n\n\n\nBiodiversity Genomics & Reference Genome SequencingEcology & EvolutionBiogeochemistry & EcosystemsData-driven Planetary Biology\,\n\n\n\nAs well as invited keynote speakers and panel discussions. \n\n\n\nread more and sign up here\n\n\n\nDay 1\, Monday 16th May\, 2022 \n\n\n\n13:00Welcome and opening remarksEdith HeardDirector General of EMBLOlli KallioniemiDirector of SciLifeLab13:10Introduction and overview of Planetary BiologyDetlev ArendtPlanetary Biology Co-Chair\, Senior Scientist\, Group Leader\, EMBLOlga Vinnere Pettersson & Stefan BertilssonCo-Leads Planetary Biology Capability\, SciLifeLab13:30Session 1: Biodiversity Genomics & Reference Genome Sequencing (15 mins + 5 mins Q&A per speaker in each session)ModeratorPeter Harrison\, Genome Analysis Team Leader\, EMBL-EBISpeakersFergal Martin\, Vertebrate Annotation Coordinator\, EMBL-EBIKerstin Lindblad Toh (remote)\, Professor in Comparative Genomics\, Uppsala University\, Scientific Director of Vertebrate Genome Biology\, Broad InstituteDetlev Arendt\, Planetary Biology Co-Chair\, Senior Scientist\, Group Leader\, EMBLOve Nilsson\, Group Leader Control of Flowering Time and Tree Phenology\, Umeå Plant Science Center14:50 Coffee break15:10Session 2: Ecology and EvolutionModeratorOlga Vinnere Pettersson\, Co-Lead Planetary Biology Capability\, SciLifeLabSpeakersLove Dalén\, Professor of Evolutionary Genetics\, Swedish Museum of Natural History\, Research Leader at Center for Palaeogenetics\, StockholmMichael Dorrity\, Group Leader Structural and Computational Biology\, EMBLJames Sharpe (remote) \, Head of EMBL Barcelona\, Group Leader in Tissue Biology and Disease ModellingAnna Rosling\, Group Leader Ecology and Evolution in Soil Fungi\, Uppsala University16:30Keynote by Mark BlaxterWellcome Sanger Institute17:15Summary and Q&A\n\n\n\nDay 2\, Tuesday 17th May\, 2022 \n\n\n\n09:00Arrival and Coffee09:30Keynote by Martin PolzUniversity of Vienna10:20Session 3: Biogeochemistry & Ecosystems(15 mins + 5 mins Q&A per speaker in each session)ModeratorStefan Bertilsson\, Co-Lead Planetary Biology Capability\, SciLifeLabSpeakersMichael Zimmermann\, Group Leader in Structural and Computational Biology\, EMBLFlora Vincent\, Incoming Group Leader in Developmental Biology; Post Doctoral Fellow at Weizmann Institute of Science\, RehovotSara Hallin\, Professor at the Department of Forest Mycology and Plant Pathology\, Swedish University of Agricultural SciencesMark Dopson\, Professor at the Department of Biology and Environmental Science\, Linnaeus University11:40 Break12:40Session 4: Data-driven Planetary BiologyModeratorOliver Stegle\, Associate Group Leader in Genome Biology\, EMBLSpeakersTomas Roslin (remote)\, Professor at the Department of Ecology\, Swedish University of Agricultural SciencesPeer Bork\, Director of EMBL Heidelberg\, Group Leader in Structural and Computational Biology\, EMBLAnders Andersson\, Group Leader in Environmental Genomics\, Royal Institute of TechnologyAnna Kreshuk\, Group Leader in Cell Biology and Biophysics14:00Summary and Q&A14:15Coffee break14:45Panel Discussion 1: Technological Infrastructure Needs for PB ResearchModeratorStefan Bertilsson\, Co-Lead Planetary Biology Capability\, SciLifeLabPanelistsYannick Schwab\, Team Leader Volume Correlative Light and Electron Microscopy and Head of Electron Microscopy Core Facility\, EMBLTimo Zimmermann\, Team Leader Advanced Light Microscopy Technology Development and Service Provision\, EMBLLinda Sandblad\, Scientific Platform Director Cellular and Molecular Imaging\, Umeå University\, SciLifeLabOlga Vinnere Pettersson\, Project coordinator at Department of Immunology\, Genetics and Pathology\, Uppsala University; Co-Lead Planetary Biology Capability\, SciLifeLabAnnika Johansson\, Head of Swedish Metabolomics Centre\, Umeå University\, SciLifeLab16:00Short break16:10Panel Discussion 2: Data Collection in PB ResearchModeratorOlga Vinnere Pettersson\, Co-Lead Planetary Biology Capability\, SciLifeLabPanelistsRainer Pepperkok\, Director of Scientific Core Facilities and Scientific Services\, Team Leader Membrane traffic and Organelle Biogenesis\, EMBLStefan Bertilsson\, Professor in Functional Ecology of Freshwaters\, Swedish University of Agricultural Sciences; Director of the Swedish Infrastructure for Ecosystem Science (SITES); Co-Lead Planetary Biology Capability\, SciLifeLabFredrik Ronqvist\, Professor in the Department of Bioinformatics and Genetics\, Swedish Museum of Natural History; Swedish Biodiversity Data Infrastructure (SBDI)16:40Panel Discussion 3: Data Management and Processing in PB ResearchModeratorFergal Martin\, Eukaryotic Annotation Team Leader\, EMBL-EBIPanelistsGuy Cochrane (remote)\, Team Leader Data Coordination and Archiving\, EMBL-EBIBlokeshwaran Manoharan\, Expert in Metagenomics; National Bioinformatics Infrastructure Sweden (NBIS)Johan Rung\, Head of Data Center\, SciLifeLab17:00Conclusion and Closing Remarks\n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\nScientific committee SciLifeLab\n\n\n\nStefan Bertilsson\, SLUOlga Vinnere Pettersson\, Uppsala University
URL:https://www.scilifelab.se/event/planetary-biology-workshop/
LOCATION:EMBL Heidelberg\, Meyerhofstraße 1\, Heidelberg\, Germany
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2021/12/AdobeStock_421805105_Planetary_biology_WP.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220516T091500
DTEND;TZID=Europe/Stockholm:20220516T163000
DTSTAMP:20260404T124212
CREATED:20220321T154432Z
LAST-MODIFIED:20220323T125900Z
UID:10000564-1652692500-1652718600@www.scilifelab.se
SUMMARY:AI / Data-driven life science
DESCRIPTION:Life science research is becoming increasingly dependent on data\, and never before has so much data been generated today. The amount and complexity increase exponentially\, and when this data becomes open to researchers around the world\, more scientific discoveries are made possible. The rapid technological development in life sciences\, combined with innovations in computing and AI\, will play an increasingly important role in research and development and affect virtually all areas of medicine and science. \n\n\n\nDuring this day\, you will meet prominent international and local researchers\, take part in current research\, and discuss open data\, AI\, ethics\, and visualization related to life science.  \n\n\n\nContacts: Carolina Wählby and Bent Persson. \n\n\n\nVenue: Ångströmslaboratoriet\, Lägerhyddsvägen 1\, Uppsala \n\n\n\nRegistration opens at the end of March.  \n\n\n\nProgram and registration will be published here! \n\n\n\n\n\n\n\nThe event is part of Uppsala University’s multidisciplinary theme week in technology and science from May 16 to 20\, at the Ångström Laboratory. During the week\, you will be able to take part in current research in AI / Data-driven life science\, the universe and mathematical physics\, materials\, energy\, and climate change.
URL:https://www.scilifelab.se/event/ai-data-driven-life-science/
LOCATION:Ångströmlaboratoriet\, Lägerhyddsvägen 1\, Uppsala\, Sweden
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220516T171500
DTEND;TZID=Europe/Stockholm:20220516T181500
DTSTAMP:20260404T124212
CREATED:20220422T112304Z
LAST-MODIFIED:20220505T130333Z
UID:10000591-1652721300-1652724900@www.scilifelab.se
SUMMARY:The Svedberg seminar: Simon Elsässer
DESCRIPTION:Register and get the link here\n\n\n\n\n\nSimon Elsässer is  Associate Professor at Karolinska Institutet\, Department of Medical Biochemistry and Biophysics. He has studied at University of Tübingen and Harvard University\, and received his Ph.D. from The Rockefeller University in 2012. He has performed postdoctoral research at MRC Laboratory of Molecular Biology and was recruited to Karolinska Institutet as a SciLifeLab Fellow in 2015. His research combines synthetic biology methods to probe and manipulate proteins in the living cell with quantitative ‘omics readouts\, focusing on stem cells\, gene expression regulation and epigenomics. \n\n\n\nTitle of the seminar: Exploring the dynamics of the pluripotent epigenome and lineage choice in development\n\n\n\n \n\n\n\nShort Abstract: \n\n\n\nThe first lineage choice made in human embryo development separates trophectoderm from the inner cell mass\, which proceeds to form the pluripotent epiblast and primitive endoderm. We discovered that Polycomb repressive complex 2 (PRC2) maintains naïve pluripotency and restricts an intrinsic capacity of pre-implantation pluripotent stem cells to give rise to extraembryonic lineages. Through quantitative ChIP-seq and single-cell transcriptomics\, we demonstrate that PRC2-mediated repression provides a highly adaptive mechanism to restrict lineage potential during early human development.Webpage: http://www.elsaesserlab.org
URL:https://www.scilifelab.se/event/simon-elsasser/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/Picture1-The-Svedberg-edited.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220518T090000
DTEND;TZID=Europe/Stockholm:20220519T130000
DTSTAMP:20260404T124212
CREATED:20220408T121642Z
LAST-MODIFIED:20220408T130957Z
UID:10000578-1652864400-1652965200@www.scilifelab.se
SUMMARY:Handling Pandemic Omics Data in the Nordics
DESCRIPTION:Dates: 18 & 19th May (9:00-13:00)\n\n\n\nLocation: online via Zoom\n\n\n\nThe current COVID-19 pandemic has understandably received considerable attention worldwide over the last few years. As it spread across the globe\, the pandemic posed significant challenges for society\, governmental bodies\, healthcare systems\, and research communities. Unprecedented efforts were necessary to  generate\, handle\, and report the sheer amount of complex data required to be able to understand how SARS-CoV-2 was spreading\, and develop efficient policies to fight the pandemic. \n\n\n\nSciLifeLab Data Centre\, ELIXIR Norway and ELIXIR Estonia have organised an online event exploring how Nordic countries handled omics data related to the SARS-CoV-2 pandemic. We invite bioinformaticians\, data stewards\, research scientists\, and anyone else interested in this topic to attend. We will focus in particular on how sequencing efforts were coordinated\, how data was managed and shared\, and how data was used and communicated to different groups. We will also discuss the importance of the FAIR principles in pandemic data management\, and which tools and pipelines facilitated efforts. We hope that this will shed light on best practices that could be adopted across the Nordics for future pandemics\, and how we might best prepare for them. We also hope to identify key resources that have wider applicability and can be reused further. \n\n\n\nThe programme is available at:  \n\n\n\nhttps://nordic-compbio.iscbsc.org/omics-data. \n\n\n\nFor any queries about the meeting\, please email nazeefaf@uio.no \n\n\n\n \n\n\n\nRegister Here
URL:https://www.scilifelab.se/event/handling-pandemic-omics-data-in-the-nordics/
LOCATION:Online event via Zoom
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220519T120000
DTEND;TZID=Europe/Stockholm:20220519T130000
DTSTAMP:20260404T124212
CREATED:20220513T080446Z
LAST-MODIFIED:20220513T080631Z
UID:10000606-1652961600-1652965200@www.scilifelab.se
SUMMARY:Campus Solna Seminar
DESCRIPTION:Seminars are back in person! \n\n\n\nThe speakers for Thursday 19 May: \n\n\n\n1) Erik Wernersson (Magda Bienko’s group\, alpha4):“deconwolf: free and open source deconvolution for widefield microscopy.” \n\n\n\n2) Carlos Gallardo Dodd (Claudia Kutter’s group\, gamma5):“Cell type-specific deployment of codons and anticodons in mammals.” \n\n\n\nTime: 12:00-13:00 \n\n\n\nPlace: Air&Fire\, SciLifeLab Campus Solna
URL:https://www.scilifelab.se/event/campus-solna-seminar/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220519T140000
DTEND;TZID=Europe/Stockholm:20220519T180000
DTSTAMP:20260404T124212
CREATED:20220330T154729Z
LAST-MODIFIED:20220330T154904Z
UID:10000576-1652968800-1652983200@www.scilifelab.se
SUMMARY:Towards characterizing the human 3D-proteome - Nobel Symposium
DESCRIPTION:Public keynote lectures: 14:00-18:00 \n\n\n\nNo registration necessary\, but when the room is full\, it is full \n\n\n\nRead more\n\n\n\n\n\n\n\nProgram\n\n\n\n14:00 Introduction – Arne Elofsson14:15 Demis Hassabis\, DeepMind\, Using AI to model biology14:45 Sarah Teichmann\, Wellcome Sanger Institute\, TBD15:15 Sergey Ovchinnikov\, Harvard\, Inverting protein structure prediction models to solve problems in biology.For this talk I’ll describe some exciting applications of protein structure prediction models such as TrRosetta\, RoseTTAFold and AlphaFold. More specifically\, I’ll describe how we can invert these models for protein design\, generation of multiple sequence alignments and navigating the conformational landscape to predict structure(s) from single sequence\n\n\n\n15:45-16:15 Coffee \n\n\n\n16:15 Debora Marks\, Harvard\, TBD16:45 Alice Y Ting\, Stanford\, Spatial proteomics and transcriptomics via enzyme-catalyzed proximity labelingWhere a protein is localized in the cell exerts tremendous influence over its function\, interaction partners\, dynamics\, and modifications. Enzyme-catalyzed proximity labeling (PL) has emerged as a powerful and generalizable method to map the locations and interactions of endogenous proteins in the context of living cells\, applicable to even membraneless organelles and transient interactions that are inaccessible to traditional methods such as affinity purification. I will give a brief account of PL method development\, including directed evolution of the PL enzymes APEX and TurboID\, and then describe new efforts to extend PL to RNA and proteome trafficking.\n\n\n\n17:15 John Jumper\, DeepMind\, TBD17:45 Final Comments\n\n\n\nThe Nobel Foundation’s symposium activities were initiated in 1965. Over the years\, they have achieved a high international standing. The symposia are devoted to science areas where breakthroughs are occurring. \n\n\n\nThis symposium aims to bring together experts from various fields with the explicit goal of outlining a joint worldwide strategy to obtain a structural map of the human proteome. In addition to determining the structure and composition of all human proteins and their interactions\, it would also require understanding the flexible and dynamic supra-molecular structures in living cells\, such as multi-component membraneless organelles. A few key findings from the last years make us believe that this goal is achievable. First\, detailed knowledge of composition (splice forms\, PTMs) and expression levels in different cells are becoming available. Secondly\, Cryo-EM has revolutionized the structural determination of large protein complexes. Finally\, using co-evolution and advances in deep learning\, it is now possible to predict the structure of many individual proteins and complexes directly using no other information than the sequences and their evolutionary history. In the next few years\, combining the progress in these three areas will provide an opportunity to provide unprecedented molecular insights into the function of cells. Theoretical methods combined with ever-increasing sequence information will enable an understanding sequence and structural variation within populations\, both in humans and in disease-causing organisms.
URL:https://www.scilifelab.se/event/towards-characterizing-the-human-3d-proteome/
LOCATION:Beijersalen\, Kungl. Vetenskapakademien\, Lilla Frescativägen 4A\, Stockholm\, Sweden
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220523T151500
DTEND;TZID=Europe/Stockholm:20220523T161500
DTSTAMP:20260404T124212
CREATED:20220422T114620Z
LAST-MODIFIED:20220523T063854Z
UID:10000592-1653318900-1653322500@www.scilifelab.se
SUMMARY:The Svedberg seminar: Tanja Slotte
DESCRIPTION:Tanja Slotte\, Assoc. Prof.Stockholm University\, Sweden \n\n\n\nRegister and get the Link\n\n\n\nAssoc. Prof. Tanja Slotte is a population geneticist who is interested in the genetic causes and genomic consequences of plant mating system shifts and the evolution of mating system supergenes. She received her PhD from Uppsala University in 2007\, followed by a postdoc at University of Toronto. She started her own group at Uppsala University in 2010 and moved to Stockholm University to take up a SciLifeLab Fellow position in 2014. She is currently Associate Professor in Ecological Genomics at Stockholm University. \n\n\n\nTitle of the seminar: Sequencing the supergene that governs Darwin’s different forms of flower\n\n\n\nSupergenes are responsible for a wide variety of balanced polymorphisms in nature\, yet our understanding of their origins and evolution remains incomplete. The reciprocal placement of stigmas and anthers in pin and thrum floral morphs of distylous species constitutes an iconic example of a balanced polymorphism governed by a supergene. Recent studies have shown that the Primula distyly S-locus supergene is hemizygous due to structural variation at the supergene. If this genetic architecture is common to other distyly supergenes\, it could have major implications for the evolution and loss of distyly. To shed further light on this question we have characterized the genetic architecture and evolution of the distyly supergene in Linum\, one of the plant systems where Dawin first described distyly. We have generated multiple high-quality genome assemblies of Linum species as a genomic framework for evolutionary studies. Here\, we leverage this framework to identify the distyly S-locus supergene and study its evolution and expression. Our results show that hemizygosity and thrum-specific expression are major features of the Linum distyly supergene\, and suggest that the supergene has arisen in a stepwise manner. Our findings demonstrate remarkable convergence in the genetic architecture\, origin and evolution of the distyly supergene among systems with independently derived distyly\, and shed light on the evolution of the classic supergene that governs Darwin’s “different forms of flowers”.
URL:https://www.scilifelab.se/event/the-svedberg-seminar-tanja-slotte/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/Picture1-The-Svedberg-edited.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220524T100000
DTEND;TZID=Europe/Stockholm:20220524T110000
DTSTAMP:20260404T124212
CREATED:20220504T155131Z
LAST-MODIFIED:20220504T155220Z
UID:10000601-1653386400-1653390000@www.scilifelab.se
SUMMARY:Solid tumours as dynamic cellular ecosystems
DESCRIPTION:Dr. Alex Swarbrick\, Garvan Institute for Medical Research\, Australia \n\n\n\nLocation: Air/FireDate: 10.00 24th of May \n\n\n\nAbstract: A well-established principle in developmental biology is that cellular context governs cell fate\, differentiation\, proliferation and survival. There is emerging evidence that solid tumours are also complex cellular systems\, or ecosystems\, in which interactions between neoplastic\, stromal and immune cells govern the natural history of disease and response to treatment. In this seminar Dr Swarbrick will discuss his latest research applying cellular genomics to understanding breast cancer ecosystems\, with the aim of making new discoveries relevant to disease stratification and treatment.
URL:https://www.scilifelab.se/event/solid-tumours-as-dynamic-cellular-ecosystems/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
ORGANIZER;CN="Joakim Lundeberg":MAILTO:joakim.lundeberg@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220524T110000
DTEND;TZID=Europe/Stockholm:20220524T115000
DTSTAMP:20260404T124212
CREATED:20220520T144620Z
LAST-MODIFIED:20220520T145411Z
UID:10000613-1653390000-1653393000@www.scilifelab.se
SUMMARY:SciLifeLab Uppsala PhD&Postdoc seminar
DESCRIPTION:Welcome to SciLifeLab Uppsala PhD&Postdoc seminars! \nWe are very happy to host exciting talks by PhD students and Postdocs from a great variety of fields within SciLifeLab. \n\n \n\n\n\nSpeaker 1: Hongxing Zhao\, Researcher at Ulf Landegren Lab (Molecular Tools)\, Dept. of Immunology\, Genetics and Pathology\n\n\n\nTitle: Detection of SARS-CoV-2 antibodies from dried blood spots of vaccine individuals by proximity extension assay Summary: We have developed a solution-phase assay for sensitive detection of SARS-CoV-2 antibodies in serum or dried blood spots (DBS) from infected or vaccinated individuals. Detection probes were prepared by conjugating the recombinant S1-RBD or nucleocapsid (NC) to either of a pair of oligonucleotides. Upon incubation with COVID-19 patient serum or DBS from vaccinated individuals\, the multivalency of the antibodies brings pairs of oligonucleotides that have been conjugated to the viral proteins in proximity. The oligonucleotides can then undergo enzymatic DNA extension via a proximity extension assay (PEA)\, and the resulting amplicons are sensitively detected by real-time PCR or end-point read out using ELISA mechine. This antibody PEA (AbPEA) test uses only 1 µl neat or diluted serum or one ø1.2 mm disc cut from a DBS. All 100 investigated sera and 21 DBS collected prior to the COVID-19 outbreak were negative\, demonstrating a 100% specificity. The sensitivity of the assay for infected patient after 10 days symptom reached 99.8% [95% confidence interval: 0.9935-1]. Anti-S1 antibodies could be detected directly in punched-out discs from self-sampled DBS 11 days after vaccination\, and it reached a maximum at 3 weeks after a first inoculation. Examination of a serially collected DBS from 14 individuals all showed similar trends of antibody responses after both a first and second vaccination\, although antibody levels varied between individuals. \n\n\n\nSpeaker 2: Manon Dubol\, PhD. Postdoctoral Researcher at Erika Comasco Neuropsychopharmacology Group\, Dept. of Women and Children’s Health\n\n\n\n\n\n\n\nTitle: Grey matter morphometry and MRI data-driven classification of premenstrual dysphoric disorder (PMDD) Summary: Premenstrual dysphoric disorder (PMDD) is recognized in the DSM-5 as a hormone-related depressive disorder\, specific to women’s mental health 1. Women who suffer from PMDD experience affective\, cognitive\, and physical symptoms that peak during the late luteal phase of the menstrual cycle\, and remit shortly in the beginning of the next cycle 2. The key affective symptoms of PMDD point to anatomical and functional brain impairment\, suggesting an impaired top-down inhibitory process involving limbic brain structures 3. However\, very little is known about brain morphological alterations in PMDD. The present study aimed at investigating the grey matter structures that distinguish women with PMDD from healthy controls\, by use of multiscale structural MRI analyses. Differences in grey matter structure between the groups were investigated by use of Voxel- and Surface Based Morphometry. Furthermore\, machine learning and multivariate pattern analysis was performed using a leave-one-fold-out cross-validation procedure\, to test whether MRI measures (volume\, thickness\, gyrification\, sulcal depth and cortical complexity) could distinguish women with PMDD from healthy controls. The findings point to PMDD-specific grey matter structure in regions of corticolimbic networks\, in line with the hypothesis of an impaired top-down inhibitory circuit involving limbic structures in PMDD. Furthermore\, the results include widespread cortical regions and cerebellar areas\, suggesting the involvement of distinct networks in PMDD pathophysiology. These effects prominently involved volumetric and cortical thickness measures\, as further highlighted by multivariate pattern classification analyses. Such differences in brain structure may help explaining the variations in brain function previously reported in women with PMDD during the symptomatic phase.
URL:https://www.scilifelab.se/event/scilifelab-uppsala-phdpostdoc-seminar/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/05/SciLifeLab-PhDPostdoc-conuncil-poster_landscape_May_24.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220524T120000
DTEND;TZID=Europe/Stockholm:20220524T130000
DTSTAMP:20260404T124212
CREATED:20220519T081250Z
LAST-MODIFIED:20220519T081441Z
UID:10000611-1653393600-1653397200@www.scilifelab.se
SUMMARY:NGS at NGI
DESCRIPTION:In the frame of the “SciLifeLab Site Umeå / KBC Infrastructure Seminar Series”\, the seminars will be organised every second Tuesday during spring 2022 in turn with IceLab Lunch Pitches. The seminars will be held in a hybrid format IRL in Glasburen\, KBC\, and online via Zoom. Take the chance to get information on facilities\, possibilities and services that infrastructure\, both SciLifeLab-associated and local\, can offer! Learn more about the seminar series and Schedule for Spring 2022 here. \n\n\n\nOn May 24th\, 12:00-13:00\, you are welcome to participate in the seminar \n\n\n\nNGS at NGI \n\n\n\nby Kristina Benevides\, Project coordinator\, National Genomics Infrastructure (NGI)\, SciLifeLab\, and research engineer in bioinformatics and sequencing\, UPSC Bioinformatics Facility\, Department of Plant Physiology\, Umeå University \n\n\n\nSeminar description\n\n\n\nGot samples? We’ve got the sequencing! NGI(https://ngisweden.scilifelab.se/) is one of the largest platforms at SciLifeLab and provides both established and cutting-edge genomics technologies to diverse user groups across Sweden and internationally. There’s a wide range of applications as NGI is equipped with both short- and long read technologies\, as well as SNP genotyping- and DNA methylation arrays. The platform assists users in project design\, data generation\, analysis and management of data in order to support genomics research in all subject areas. \n\n\n\nPrepare for your next (generation) sequencing experiment as we’ll get into the nitty-gritty of some different methods\, sample types and requirements. \n\n\n\nThere will be a fun online science quiz at the end – participate to win some swag! \n\n\n\nRegistration\n\n\n\nSign up (latest by May 23rd\, 10 a.m.) for on-site attendance to reserve your free lunch sandwich: \n\n\n\nsign up\n\n\n\nor follow online via Zoom: https://umu.zoom.us/j/63138997026 (registration is not required). \n\n\n\nOrganisers\n\n\n\nSciLifeLab Site Umeå and Chemical Biological Centre (KBC)
URL:https://www.scilifelab.se/event/ngs-at-ngi/
LOCATION:Glasburen Seminar Room\, Chemical Biological Centre (KBC) Building\, Umeå University\, Umeå\, 901 87\, Sweden
CATEGORIES:Event
ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220525T130000
DTEND;TZID=Europe/Stockholm:20220525T140000
DTSTAMP:20260404T124212
CREATED:20220507T134201Z
LAST-MODIFIED:20220510T114934Z
UID:10000603-1653483600-1653487200@www.scilifelab.se
SUMMARY:A novel\, antibody-based radiopharmaceutical for advanced thyroid cancer
DESCRIPTION:Presenter: Dr Marika Nestor\, Department of Immunology\, genetics and pathology\, Uppsala University\, Sweden \n\n\n\nMolecular radiotherapy is increasingly becoming a powerhouse in the field of cancer- and radiation therapy. By targeting a structure that is abundant on tumor cells but scarce in healthy tissues\, a cancer-targeting molecule labeled with a therapeutic radionuclide can mediate the delivery of radioactivity specifically to cancer cells. This creates a targeted\, localized form of radiotherapy that combines the advantages of systemic therapy with therapeutically effective radiation. \n\n\n\nIn a collaboration with the Drug Discovery & Development platform at Science for Life Laboratory\, we have developed an antibody-based radiopharmaceutical for molecular radiotherapy of advanced thyroid carcinoma. The project spans over the whole early development chain; from preclinical innovation in the lab\, dosimetry and proof-of-concept in animal models\, to upscaled production and preparations for first-in-man studies. \n\n\n\nDr Nestor in her presentation will discuss the process from innovation to implementation of the project\, both from a research and a commercialization perspective. \n\n\n\nsign up here\n\n\n\nMarika Nestor leads a translational research group at the Department of Immunology\, Genetics and Pathology\, Uppsala University. Her research group focuses on radionuclide targeting and radiosensitization of cancer cells. She obtained her PhD at Uppsala University in 2006\, and became an Associate Professor in 2012. In 2013 she was awarded the Göran Gustafsson prize for young scientists\, in 2016 the Junior Investigator Award from the Swedish Cancer Society\, and in 2020 the Senior Investigator Award. In 2019\, she was awarded a grant from Sweden’s innovation agency VINNOVA to facilitate clinical translation of her findings\, as well as an Attractive Innovation Award by UU Innovation.
URL:https://www.scilifelab.se/event/a-novel-antibody-based-radiopharmaceutical-for-advanced-thyroid-cancer/
LOCATION:Online event via Zoom
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220530T080000
DTEND;TZID=Europe/Stockholm:20220610T170000
DTSTAMP:20260404T124212
CREATED:20220203T142206Z
LAST-MODIFIED:20220210T134248Z
UID:10000520-1653897600-1654880400@www.scilifelab.se
SUMMARY:New Imaging and Fluctuation Methods: Super-Resolution\, Light-Sheet\, STED-FCS and FRET-FCS
DESCRIPTION:Web-based PhD-level course\, 3 hp credits\, by the ALM facility at Scilifelab. \n\n\n\nFlyer_220119\n\n\n\nLight-Sheet Imaging\n\n\n\nLong time-lapse imaging of live modelorganisms with low phototoxicityCombined light-sheet andsuper-resolution\n\n\n\nSuper-Resolution Imaging in Living Cells – MoNaLISA\n\n\n\nSmart probes50 nm resolution at 1-2 Hz100 x 100 um field of view time lapse imaging\n\n\n\n \n\n\n\nSTED-FCS\n\n\n\nFluctuation spectroscopy with 30 nm resolutionSub-diffraction dynamics in living cells\n\n\n\n \n\n\n\nFRET-FCS\n\n\n\nEasy detection of protein-protein interactions in living cellsHighly sensitive detection of rare oligomers in living cells\n\n\n\nLecturers\n\n\n\nAndreas BodénErdinc SezginIlaria TestaStefan Wennmalm\, stewen@kth.se \n\n\n\nRegistration\n\n\n\nPlease register by sending an e-mail with your contact details to: stewen@kth.se.Registration deadline: May 20\, 2022
URL:https://www.scilifelab.se/event/new-imaging-and-fluctuation-methods-super-resolution-light-sheet-sted-fcs-and-fret-fcs/
LOCATION:Online event via Zoom
CATEGORIES:Course
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220530T160000
DTEND;TZID=Europe/Stockholm:20220530T170000
DTSTAMP:20260404T124212
CREATED:20220421T091500Z
LAST-MODIFIED:20220421T112618Z
UID:10000588-1653926400-1653930000@www.scilifelab.se
SUMMARY:FAIRPoints-Enhancing Sample Provenance and Experimental Reproducibility
DESCRIPTION:Location: Online via Zoom \n\n\n\n\n\nSee Event in your Time Zone \n\n\n\nSpeaker: Rory Macneil  \n\n\n\nLack of reliable information about sample usage\, location\, provenance\, metadata and experimental use is a core barrier to experimental reproducibility and general FAIRification of data. This presentation will describe how these issues are being addressed in the design and development of a sample management module within the RSpace electronic lab notebook\, focusing on three specific challenges: (1) Incorporating sample data into experimental documentation; (2) Associating PIDS like IGSNs and RRIDS into sample metadata; and (3) Export of sample metadata in required formats to different domain repositories and databases.  \n\n\n\nFAIRPoints is an event series highlighting pragmatic measures developed by the community towards the implementation of the FAIR (Findable\, Accessible\, Interoperable\, Reusable) data principles\, in collaboration with GoFAIR US\, SDSC\, AGU\, and SciLifeLab Data Centre. \n\n\n\nSpeaker bio: \n\n\n\nRory Macneil is CEO of Research Space\, which provides RSpace\, an electronic lab notebook and research data management platform\, and host of the FAIR Data Podcast.  In these roles\, and through participation in organizations and forums like the Research Data Alliance\, numerous conferences and events\, and conversations with researchers\, research data managers\, policy makers\, funders\, and tools developers\, he enjoys exploring practical ways in which FAIRification of data can be advanced. \n\n\n\n\n\n\n\nRegister here\n\n\n\nSign up for future events here \n\n\n\nTwitter: @FAIR_Points
URL:https://www.scilifelab.se/event/fairpoints-sample-provenance/
LOCATION:Online event via Zoom
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220531T130000
DTEND;TZID=Europe/Stockholm:20220531T140000
DTSTAMP:20260404T124212
CREATED:20220517T144221Z
LAST-MODIFIED:20220518T143138Z
UID:10000609-1654002000-1654005600@www.scilifelab.se
SUMMARY:Webinar: Funding and support from Novo Nordisk Foundation and BioInnovation Institute
DESCRIPTION:SciLifeLab invites the Novo Nordisk Foundation and the BioInnovation Institute (BII) to a webinar where they will present organizations\, grant and funding instruments\, upcoming programs and tips and tricks for a successful application. \n\n\n\n\n\n\n\nMAY 31\, at 13:00 – 14:00 \n\n\n\nThe Novo Nordisk Foundation is an international foundation focusing on improving people’s lives and sustainability of the society. The Foundation awards grants for research projects based on applications it receives in open competition and for strategic projects for which the Foundation takes the initiative. The Foundation has two grant instruments within Innovation\, the Pioneer innovator Grant and the Distinguished Innovator Grant\, both of which are open for researchers in the Nordic countries.  \n\n\n\n\n\n\n\nBioInnovation Institute (BII) is an international commercial foundation with a non-profit objective supported by the Novo Nordisk Foundation. BII operates an incubator to accelerate world-class life science innovation that drives the development of new solutions through the creation of life science start-ups for the benefit of people and society. BII offers help to early-stage projects and start-ups in health tech\, bio-industrials and therapeutics through their various programs. They can provide funding up to 2.5m euros. They are open for applications twice a year. September is the next deadline for applications.  \n\n\n\n\n\n\n\nRegister for the Webinar\, May 31\n\n\n\nRegistration\n\n\n\n\n\n\n\nFollowing event:\n\n\n\nSciLifeLab BII pitch days\n\n\n\nJune 16\, 14:00-17:00 and June 17\, 10:00-12:00 \n\n\n\nThe webinar on May 31\, is followed by two pitch days where researchers are given the opportunity to pitch their ideas to the BII team. The purpose is to get feedback and guidance from business developers on your idea and to learn if your project could be a fit for their different innovation programes and funding instruments.  \n\n\n\nRead more
URL:https://www.scilifelab.se/event/webinar-funding-and-support-from-novo-nordisk-foundation-and-bioinnovation-institute/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="External Relations Office":MAILTO:externalrelations@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220601T080000
DTEND;TZID=Europe/Stockholm:20220602T170000
DTSTAMP:20260404T124212
CREATED:20220210T084528Z
LAST-MODIFIED:20220404T085555Z
UID:10000524-1654070400-1654189200@www.scilifelab.se
SUMMARY:Swedish Microfluidics in Life Science (SMILS) 2022
DESCRIPTION:The Swedish Microfluidics in Life Science meeting gathers researchers in the field of micro- and nanofluidics\, and offers an opportunity to present your research\, to network with researchers at Swedish universities\, institutes and companies\, and to listen to invited talks by a panel of well reputed research leaders. \n\n\n\n\n\n\n\nABSTRACT DEADLINE: APRIL 15\, 2022\n\n\n\n\n\n\n\nREGISTRATION DEADLINE: MAY 25\, 2022\n\n\n\n\n\n\n\nSave the date and please help spread this information in your groups and local networks. \n\n\n\nRegistration\n\n\n\nRead more
URL:https://www.scilifelab.se/event/swedish-microfluidics-in-life-science-smils-2022/
LOCATION:Ångström Laboratory\, Lägerhyddsvägen 1\, Uppsala\, Sweden
CATEGORIES:Event
ORGANIZER;CN="Swedish Microfluidics in Life Sciences":MAILTO:per.augustsson@bme.lth.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220601T100000
DTEND;TZID=Europe/Stockholm:20220601T110000
DTSTAMP:20260404T124212
CREATED:20220524T110815Z
LAST-MODIFIED:20220525T084417Z
UID:10000617-1654077600-1654081200@www.scilifelab.se
SUMMARY:Serial biomarker measurements and cardiovascular disease
DESCRIPTION:Datum: 1 juni\, kl. 10.00 Plats: Biomedicinskt centrum Navet BMC E10:3309\, SciLifeLab Uppsala. Föreläsare: Isabella Kardys Kontaktperson: Agneta Siegbahn Seminarium
URL:https://www.scilifelab.se/event/serial-biomarker-measurements-and-cardiovascular-disease/
LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden
CATEGORIES:Event
ORGANIZER;CN="Affinity Proteomics":MAILTO:affinity.proteomics-uppsala@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220601T130000
DTEND;TZID=Europe/Stockholm:20220601T170000
DTSTAMP:20260404T124212
CREATED:20220328T072007Z
LAST-MODIFIED:20220524T110502Z
UID:10000570-1654088400-1654102800@www.scilifelab.se
SUMMARY:Biomarkers of Clinical Relevance – The ABC Risk Scores in Cardiovascular Diseases
DESCRIPTION:Symposium on the ABC study\n\n\n\nIn the ABC Risk Score project new tools for precision medicine in cardiovascular diseases have been developed. At this half-day symposium achievements obtained within the project will be presented and discussed. The ABC Risk Score project has been financed for 5 years by the Swedish Foundation for Strategic Research. \n\n\n\nThe symposium is free of charge\, including coffee and some light refreshments.  \n\n\n\nWe kindly ask those who plan to attend the coffee break and evening mingle to register by May 20. \n\n\n\n\n\n\n\n\nREGISTRATION\n\n\n\nPROGRAM
URL:https://www.scilifelab.se/event/biomarkers-of-clinical-relevance-the-abc-risk-scores-in-cardiovascular-diseases/
LOCATION:Martin H:son Holmdahlsalen\, Dag Hammarskjöldsväg 8\, Entrance 100\, Akademiska sjukhuset\, Uppsala
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220601T151500
DTEND;TZID=Europe/Stockholm:20220601T164500
DTSTAMP:20260404T124212
CREATED:20220524T081629Z
LAST-MODIFIED:20220601T073613Z
UID:10000615-1654096500-1654101900@www.scilifelab.se
SUMMARY:POSTPONED - SciLifeLab COVID-19 seminars: Drug repurposing and Precision Medicine - Philip Gribbon & Päivi Östling 
DESCRIPTION:This seminar is unfortunately postponed due to illness – new date not decided yet\n\n\n\nPhilip Gribbon & Päivi Östling\n\n\n\nThe fourth SciLifeLab COVID-19 seminar this spring starts with  Philip Gribbon\, Head of Discovery Research\, Fraunhofer Institute for Translational Medicine and Pharmacology\, Hamburg\, Germany\, talking about ” Compound repurposing in COVID-19\, target and phenotypic-based approaches“. The second talk\, “Exploring the morphology of the host cell to open new possibilities in drug repurposing” will be given by  Päivi Östling\, Department of Oncology-Pathology\, Karolinska InstitutetModerator: Annika Jenmalm Jensen\, SciLifeLab Infrastructure Director \n\n\n\n\n\n\n\nRegister here to Get the Link to the seminar\n\n\n\n\n\n\n\nSchedule\n\n\n\n15:15- 16:00Compound repurposing in COVID-19\, target and phenotypic-based approaches Philip Gribbon Fraunhofer Institute for Translational Medicine and Pharmacology\, Hamburg\, Germany16:00-16:45Exploring the morphology of the host cell to open new possibilities in drug repurposingPäivi Östling Department of Oncology-Pathology\, Karolinska Institutet\n\n\n\n\n\n\n\n\nBIOS and ABSTRACTS
URL:https://www.scilifelab.se/event/scilifelab-covid-19-seminars-philip-gribbon-paivi-ostling/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2021/05/covid_3d_model-min-1536x864-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220602T100000
DTEND;TZID=Europe/Stockholm:20220602T110000
DTSTAMP:20260404T124212
CREATED:20220517T094756Z
LAST-MODIFIED:20220524T110320Z
UID:10000608-1654164000-1654167600@www.scilifelab.se
SUMMARY:The Fair Journal: Science Cartoons for the People
DESCRIPTION:Jonas N. Søndergaard\n\n\n\nThe Fair Journal is run by active scientists passionate about spreading recent scientific findings in an understandable and truthful manner to kids and non-scholarly educated adults (https://thefairjournal.com). Their specialty is making cartoons explaining the essence of research articles to kids\, with a focus on storytelling and making it fun. They also publish a written summary in a language that non-scholarly educated people can understand. In this BAM presentation\, Jonas will talk about how the Fair Journal’s system works\, how they produce the cartoons\, and how scientists can earn from their own layman summaries. \n\n\n\njoin zoom meeting\n\n\n\nJonas Søndergaard is current an Assistant Professor at Osaka University in Japan. Previously\, he  performed research in Sweden (SciLifeLab)\, Netherlands\, Denmark\, and the US. His main research focus is immunology\, but he is also interested in all fields of science ranging from engineering\, to medical sciences\, and social sciences. He envisioned the idea for the Fair Journal while working at SciLifeLab.  \n\n\n\nResearchers in all stages of their career are welcome to attend and could find the talk useful. Kindly feel free to extend the invitation to your home universities.  \n\n\n\nFlyer-BAM-Jonas.N.Söndergaard_editedDownload
URL:https://www.scilifelab.se/event/the-fair-journal-science-cartoons-for-the-people/
LOCATION:Online event via Zoom
CATEGORIES:Community
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220602T120000
DTEND;TZID=Europe/Stockholm:20220602T130000
DTSTAMP:20260404T124212
CREATED:20220525T130600Z
LAST-MODIFIED:20220525T130622Z
UID:10000618-1654171200-1654174800@www.scilifelab.se
SUMMARY:Campus Solna Seminar - Isabelle Leo and Shan Chen
DESCRIPTION:Welcome to the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between the alpha and gamma buildings. The format will be 2 short 15 min talks (1 speaker from alpha and 1 from gamma)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-12:50 and in Air&Fire\, SciLifeLab Stockholm. \n\n\n\n\n\n\nIsabelle Leo\n\n\n\nJanne Lehtiö\, Alpha 1 \n\n\n\nUsing proteomics to understand biology and biomarkers in childhood acute lymphoblastic leukemia. \n\n\n\n \n\n\n\n \n\n\n\n\n\nShan Chen \n\n\n\nOla Larsson\, Gamma 6 \n\n\n\nPABP prevents the untimely decay of select mRNA populations in human cells
URL:https://www.scilifelab.se/event/campus-solna-seminar-isabelle-leo-and-shan-chen/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220607T090000
DTEND;TZID=Europe/Stockholm:20220607T120000
DTSTAMP:20260404T124212
CREATED:20220121T160255Z
LAST-MODIFIED:20220121T160256Z
UID:10000515-1654592400-1654603200@www.scilifelab.se
SUMMARY:BioImage Analysis support - Call4Help
DESCRIPTION:Every 1st week of the month (mainly on Tuesdays\, but there might be exceptions) the BioImage Informatics Facility together with microscopy expert Sylvie Le Guyader (LCI\, Karolinska Institutet) organizes a Call4Help session. The aim is to offer combined expertise towards microscopy and bioimage analysis. All researchers from Swedish institutes can participate. \n\n\n\nThe ideal timepoint to join the Call4Help session is when a researcher has performed pilot experiments and has tried out first analysis approaches – but before having recorded hundreds of images. Combining BIIF’s expertise in BioImage Analysis with microscopy expertise we can discuss ways to record the images that allow analysis afterwards. We will discuss different analysis approaches using mainly open-source software (Fiji\, CellProfiler\, QuPath\, Ilastik\, KNIME)\, but also commercial systems\, if needed (Imaris). \n\n\n\nThe Call4Help session format has been introduced to the BioImage Analysis community by NEUBIAS and ScopeM. \n\n\n\nHow to participate? \n\n\n\nStep1: \n\n\n\nPrepare a short presentation (5-7 min)  – use the following template for your presentation: \n\n\n\nhttp://bit.ly/BIIF_C4H_slideTemplate \n\n\n\nSlide template by NEUBIAS/ScopeM \n\n\n\nStep2: \n\n\n\na) Upload your presentation \n\n\n\nUpload your presentation to a drive of your choice. You can also use our Call4Help google drive. Note that files shared on our Call4Help drive will be available to everyone until the session is over. \n\n\n\nhttp://bit.ly/BIIF_C4H_Drive \n\n\n\nb) Upload example images for testing. \n\n\n\nUpload example images for testing either to the drive of your choice or our Call4Help google drive above. \n\n\n\nhttp://bit.ly/BIIF_C4H_Drive \n\n\n\nc) Register by filling out the registration form: \n\n\n\nhttp://bit.ly/BIIF_C4H_Registration \n\n\n\nStep 3: \n\n\n\nJoin the zoom-session. \n\n\n\nIf your problem is selected for presentation\, you will get a time-slot of 30 – 60 minutes within the session. \n\n\n\nWhat are the Deadlines \n\n\n\nSubmission of a problem and upload of example data: Friday the week before the session. \n\n\n\nNotification about participation: The day before the session. \n\n\n\nNext Call4Help session \n\n\n\nTuesday\, June 7\, 2022\, 9.00-12.00. Deadline for application: Friday\, June 3\, 2022.
URL:https://www.scilifelab.se/event/bioimage-analysis-support-call4help-5/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="Bioimage Informatics Unit":MAILTO:biif@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220607T110000
DTEND;TZID=Europe/Stockholm:20220607T120000
DTSTAMP:20260404T124212
CREATED:20220602T155036Z
LAST-MODIFIED:20220603T141658Z
UID:10000622-1654599600-1654603200@www.scilifelab.se
SUMMARY:SciLifeLab Uppsala PhD&Postdoc seminar
DESCRIPTION:ZOOM link\n\n\n\n\n\n\n\nWelcome to SciLifeLab Uppsala PhD&Postdoc seminars! \nWe are very happy to host exciting talks by PhD students and Postdocs from a great variety of fields within SciLifeLab. \n \nSpeaker 1: Gustav Arvidsson\, Researcher at Jessica Nordlund Lab (Molecular Precision Medicine)\, Dept. of Medical Sciences \nTitle: B-cells in primary Sjögren’s syndrome studied by scRNA-seqSummary: Primary Sjögren’s syndrome (pSS) is an autoimmune disease where the main clinical indication is an increased lymphocyte infiltration to the salivary and lacrimal glands\, leading to a dry mouth and dry eyes. Auto-antibodies to SSA or SSB are present in the majority of the cases and these can often be detected long before symptoms arise. The disease primarily affects middle aged women and while the disease manifestation is mild for most patients about a third develop more severe systemic symptoms and 5% of the patients develop B-cell lymphomas. Given the prominent role of B-cells in the onset and progression of pSS the present study aims to interrogate differences in B-cell subtype composition\, clonotype distribution and gene expression differences between patient subgroups for different B-cell subtypes by means of scRNA-seq. For this purpose\, we have generated gene expression and targeted B-cell receptor libraries for ~230 000 unique purified B-cells from 24 patients and healthy controls which we hope can broaden the understanding of the role of B-cells in pSS. \nSpeaker 2: David Lagman\, Researcher at Dan Larhammar Lab(Pharmacology)\, Dept. of Medical Cell Biology \nTitle: Evolution of genes important for nervous system function in vertebrates with a focus on visionSummary: Whole genome duplications (WGDs) at the base of the vertebrate lineage have over the years been shown to be responsible for the expansion of many gene families that are important in vertebrate central nervous system function. We have previously resolved the evolution of many of these genes in relation to these WGDs\, especially those involved in neuronal\, neuroendocrine\, and visual function. Here\, I will describe our latest results regarding the evolution of cyclic nucleotide gated cation (CNG) channel genes in metazoans. The CNG channels play an important role in vision in vertebrates by being responsible for the hypopolarization of cone and rod photoreceptor cells after the detection of light. Using extensive datamining we have managed to identify four previously unknown CNG channel genes in several invertebrate lineages. We have also managed to\, through detailed analyses of conserved synteny\, accurately assign vertebrate CNG genes to related chromosomal regions providing strong evidence for an expansion in the early vertebrate WGDs. These analyses open up the door for investigations into the function of the novel CNG genes identified in invertebrate genomes. Finally\, I will describe our current endeavor into understanding the evolution of genes involved in long term memory formation and maintenance in vertebrates.
URL:https://www.scilifelab.se/event/scilifelab-uppsala-phdpostdoc-seminar-2/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/05/SciLifeLab-PhDPostdoc-conuncil-poster_landscape_June_07.png
END:VEVENT
END:VCALENDAR