BEGIN:VCALENDAR VERSION:2.0 PRODID:-//SciLifeLab - ECPv6.15.18//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:SciLifeLab X-ORIGINAL-URL:https://www.scilifelab.se X-WR-CALDESC:Events for SciLifeLab REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20230326T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20231029T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20250330T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20251026T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240616T080000 DTEND;TZID=Europe/Stockholm:20240620T170000 DTSTAMP:20260404T171137 CREATED:20240219T110329Z LAST-MODIFIED:20240219T110353Z UID:10001164-1718524800-1718902800@www.scilifelab.se SUMMARY:Advanced course in Metabolic Engineering & Systems Biology (MESB) DESCRIPTION:The advanced course in Metabolic Engineering & Systems Biology (MESB) is organized by the Systems and Synthetic Biology division at Chalmers University of Technology\, and is intended for PhD students\, postdocs\, academic and industrial researchers that are interested in computational aspects of metabolic engineering. \n\n\n\nAim & content\n\n\n\nThe aim of the course is to provide participants with a strong primer of various (computational) aspects of metabolic engineering. In particular\, the course covers the following topics: \n\n\n\n\nConstraint-based genome-scale modelling\n\n\n\nEnzyme-constrained modelling\n\n\n\nFermentation technologies\n\n\n\nProteomics technologies\n\n\n\nRNAseq data generation and analysis\n\n\n\nIntegrative gene-expression data analysis\n\n\n\n\nA central question in all the activities is How can I use this in my metabolic engineering project? \n\n\n\nTeaching format\n\n\n\nThe course is intensive and will require precourse studying of material that will be provided closer to the start date. During the course\, teaching will be via lectures\, while also significant time (most afternoons) is allocated for hands-on computer exercises. \n\n\n\nLecturers\n\n\n\nEduard KerkhovenJosé Luis Martínez RuizPetri-Jaan LahtveeVerena SiewersYun ChenCHALMERS\, SwedenDTU\, DenmarkTalTech\, EstoniaCHALMERS\, SwedenCHALMERS\, Sweden URL:https://www.scilifelab.se/event/advanced-course-in-metabolic-engineering-systems-biology-mesb/ CATEGORIES:Course ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240617T130000 DTEND;TZID=Europe/Stockholm:20240617T140000 DTSTAMP:20260404T171137 CREATED:20240508T124016Z LAST-MODIFIED:20240516T084026Z UID:10001258-1718629200-1718632800@www.scilifelab.se SUMMARY:How protein degraders work: Molecular mechanism and drug design DESCRIPTION:Alessio Ciulli \n\n\n\n\n\n\n\nProfessor of Chemical Structural Biology \n\n\n\nFounder and Director\, Centre for Targeted Protein Degradation \n\n\n\nSchool of Life Sciences\, University of Dundee \n\n\n\nAbstract\n\n\n\nProtein degraders (also known as PROTACs and molecular glues) are a new class of small molecule tools and drugs that trigger the rapid depletion of a target protein inside the cell. Degraders work via forming a ternary complex\, bridging a target protein to a ubiquitin E3 ligase. This allows the E3 ligase to label the target protein with ubiquitin molecules\, leading to the protein being recognized and degraded by the proteasome. Whereas conventional drugs only inhibit disease-causing proteins by binding and locking up their most important functional parts for the duration of the drug’s action\, degraders can bind at any positions and cause the protein rapid and long-lasting destruction. This lecture will recount some of our fundamental discoveries and insights that have helped to advance understanding and illuminate the molecular mechanism of how degraders work. It will illustrate how such fundamental principles have been applied to design high-quality degraders against challenging drug targets\, and will highlight some of the latest progress from the laboratory. \n\n\n\nBiography\n\n\n\nAlessio Ciulli studied chemistry in Florence\, Italy\, and obtained his PhD from the University of Cambridge\, UK\, in 2006. After postdoctoral research in Cambridge and a brief visit at Yale University in the USA\, he returned to Cambridge in 2009 to start his independent laboratory. In 2013\, he moved to the University of Dundee\, UK\, where he was promoted to full professor in 2016. He has received numerous prizes and awards for his discoveries\, most recently the 2022 Prous Institute – Overton and Meyer Award for New Technologies in Drug Discovery from the European Federation of Medicinal Chemistry (EFMC). In 2023 he was elected Fellow of the Royal Society of Edinburgh. He is the scientific founder of Amphista therapeutics\, a targeted protein degradation company spin out of his laboratory\, and the founder and director of the University of Dundee’s new Centre for Targeted Protein Degradation which opened in January 2023. The Ciulli Laboratory focuses on chemical biology and structural biology to develop small molecules inducing targeted protein degradation and modulating protein-protein interactions and translates their fundamental research via collaboration partnership with the biopharma industry and by creation of spin-out companies. URL:https://www.scilifelab.se/event/how-protein-degraders-work-molecular-mechanism-and-drug-design/ LOCATION:Petrén Hall\, Nobels väg 12B\, Solna\, 17121\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240617T140000 DTEND;TZID=Europe/Stockholm:20240617T190000 DTSTAMP:20260404T171137 CREATED:20240426T121303Z LAST-MODIFIED:20240614T210606Z UID:10001238-1718632800-1718650800@www.scilifelab.se SUMMARY:Open House at Campus Solna DESCRIPTION:Welcome to SciLifeLab Campus Solna!\n\n\n\nTake the opportunity to tour some of the SciLifeLab infrastructures hosted at Campus Solna organized by: \n\n\n\n\nChemical Biology & Genome Engineering and Drug Discovery & Development platforms\n\n\n\nGenomics (NGI)\, Cell & Molecular Imaging and Integrated Structural Biology platforms\n\n\n\nSpatial Biology platform\n\n\n\nClinical Genomics and Clinical Proteomics & Immunology platforms\n\n\n\nMetabolomics platform – Exposomics\n\n\n\n\nThis open house is open to everyone interested in learning more about the SciLifeLab Research infrastructures available to life science experts all over Sweden. \n\n\n\nLast day to register is June 11th \n\n\n\nRegister Here\n\n\n\nProgram\n \n\n\n\n13.30Registration and Coffee14.00Welcome to SciLifeLab!Instructions\, information and introductions to tour sessionsPer Ljungdahl\, Campus Solna Director14.15Tour Session #15 different tours available\, presented below15.00Tour Session #25 different tours available\, presented below15.45Tour Session #35 different tours available\, presented below16.30Poster sessionMeet all the SciLifeLab Platforms and research infrastructures17.00Mingle with light food and pub\n\n\n\n\nTours\nEach tour is repeated 3 times. Participants can choose 1 of 5 tours for each occasion. Participation in 3 different tours is possible \n\n\n\n\nAcademic drug discovery projects and services – small molecule and genetic perturbations on biological systemsorganised by  Chemical Biology & Genome Engineering and Drug Discovery & Development platforms\n\n\n\nCryoEM / ALM / NGI – Intricate genomes and super resolution imaging with electrons and photonsorganised by Genomics (NGI)\, Cell & Molecular Imaging and Integrated Structural Biology platforms\n\n\n\nSpatial transcriptomics using in situ sequencingorganised by Spatial Biology platform\n\n\n\nGenomic-based analyses using next generation sequencing and protein analyses using cutting edge immunoassay technologiesorganised by Clinical Genomics and Clinical Proteomics & Immunology platforms\n\n\n\nExposomics: National infrastructure to study chemical exposures in human and the environmentorganised by Metabolomics platform\n\n\n\n\n\n\n\n\n\nOrganizers\n\n\n\nMarta CarroniAnna-Lena GustafssonAnna GellerbringKatarina TiklovaStefano PapazianPer LjungdahlIsolde Palombo URL:https://www.scilifelab.se/event/open-house-at-campus-solna/ LOCATION:SciLifeLab Campus Solna\, Tomtebodavägen 23 A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/04/Campus-Solna-Open-House.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240618T080000 DTEND;TZID=Europe/Stockholm:20240619T170000 DTSTAMP:20260404T171137 CREATED:20231020T081018Z LAST-MODIFIED:20240618T044504Z UID:10001007-1718697600-1718816400@www.scilifelab.se SUMMARY:Facility Forum 2024 DESCRIPTION:Dear SciLifeLab Infrastructure Team\, \n\n\n\nWe have finally arrived! It’s time for the SciLifeLab Facility Forum 2024. We look forward to your participation in this engaging and informative experience on June 18-19\, 2024\, at the Clarion Sign Hotel in central Stockholm.This year\, the event will bring together 442 participants\, continuing the growth from the first Facility Forum in Uppsala in 2017 with 253 participants\, 338 in Djurönäset in 2019\, and 376 for the last meeting in Djurönäset in 2022. The primary objectives of the meeting are to promote cross-facility collaborations\, increase community feeling among platform and facility personnel\, discuss specific infrastructure issues\, foster competence development\, and provide ample time for discussion and exchange.One highlight of the event will be a session with the current and new SciLifeLab directors\, where they will share and discuss their visions for the future of Life Science and SciLifeLab. Additionally\, the program includes various sessions and workshops aimed at enhancing collaboration and professional growth.We are excited to have you join us! Below\, you can find all the important information you need to know to make your participation easier. \n\n\n\nAnnika Jenmalm Jensen\, Infrastructure Director SciLifeLabLars Johansson\, Infrastructure Coordinator SciLifeLab \n\n\n\n \n\n\n\n\n\n\n\n \n\n\n\nMeet the speakers\n\n\n\n\n\n\n\n\n\nDr. Kelly Vere\, MBE\, is Director of Technical Strategy at the University of Nottingham\, UK. She is a passionate advocate for technical skills\, roles and careers and has created\, facilitated and led a number of opportunities for the technical community\, including the new UK Institute for Technical Skills & Strategy and the Technician Commitment initiative. \n\n\n\nKeynote \n\n\n\nA path for everyone: creating sustainable scientific careers \n\n\n\nFrom the shadows to the spotlight: the UK’s approach to elevating technical contributions to research and innovation \n\n\n\n\n\n\n\n\n\nAlessio Ciulli is Professor of Chemical and Structural Biology and Director of the Centre for Targeted Protein Degradation\, University of Dundee\, UK. At Facility Forum\, he will present a keynote about the importance of self-leadership\, engagement\, and inclusion to build a successful team. \n\n\n\nKeynote \n\n\n\nTeam building\, leadership\, inclusion and good competition \n\n\n\nThe importance of self-leadership\, engagement\, and inclusion to build a successful team. \n\n\n\n\n\n\n\n\n\nProgram\n\n\n\n \n\n\n\nFF-ProgramDownload\n\n\n\nPractical information\n\n\n\nA Blossoming Banquet \n\n\n\nA grand banquet will take place on the evening of June 18. The theme for the dinner will be a floral celebration – so wear your flowery dress\, hat or suit! And\, your creative skills may be put to the test! \n\n\n\nThe Facility Forum Podcast \n\n\n\nContribute and make your voice heard in the Facility Forum Podcast. Submit your wish to join here.  Kindly include a few lines about your role and a story you would like to highlight. \n\n\n\n \n\n\n\nBus transfer from/to Uppsala \n\n\n\nSciLifeLab will provide direct bus transfer from Uppsala (BMC) to the venue\, and back. The bus departs from Uppsala BMC\, June 18\, 07:45\, and from Clarion Sign at 15:30 on Wednesday\, June 19. \n\n\n\nCloakroom & Registration \n\n\n\nLeave your luggage in the cloakroom\, staffed from 09 to 17 on Tuesday and from 08 to 16 on Wednesday. We can not accept luggage other than small handbags and regular (e.g.\, laptop) backpacks in the Big Hall. \n\n\n\nRegistration opens at 09:00 at the Clarion Sign; the registration area is next to the Conference entrance. Register by showing the QR code that will be emailed to you shortly before the Conference. The nametags are sorted by Last name. \n\n\n\nHotel check-in/out \n\n\n\nCheck-in: The room will be available from 16:00. Rooms at Clarion Sign are available outside the lecture all after the end of the day’s sessions. \n\n\n\nAbout 100 participants are staying at Clarion Hotel Amaranten\, 10 minute walk from Clarion Sign. You will find your keycard at Amaranten. \n\n\n\nCheck-out: Leave the key card by the Hotel reception desk after breakfast. Put your luggage in the cloakroom. To facilitate check-out\, you cannot put anything on the room bill\, such as snacks and drinks or a bar tab. \n\n\n\n \n\n\n\nWorkshops\n\n\n\nThere will be three rounds of workshops\, with two taking place on both Tuesday and Wednesay. The Session “Hands-on with Large Language Models” is part of the plenary program. Workshop instructions has been sent out in advance. \n\n\n\n\n\n\n\nList of workshopsDownload URL:https://www.scilifelab.se/event/facility-forum-2024/ LOCATION:Clarion Sign Hotel\, Östra Järnvägsgatan 35\, Stockholm\, Stockholm\, 111 20\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/10/Facility-Forum-Square.png ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240619T090000 DTEND;TZID=Europe/Stockholm:20240619T120000 DTSTAMP:20260404T171137 CREATED:20240614T151702Z LAST-MODIFIED:20240614T151815Z UID:10001276-1718787600-1718798400@www.scilifelab.se SUMMARY:Uppsala University DDLS Fellows - public seminars with candidates DESCRIPTION:Evolution and Biodiversity in the light of massive data details\n\n\n\nMeeting details\n\n\n\nWednesday\, June 19\, 2024 9:00-12:00 \n\n\n\nLocation: Lindahl-hall\, EBC Uppsala University. The meeting will also be on Zoom. Join us on: Zoom link >>   \n\n\n\nPasscode: DDLS \n\n\n\nSchedule\n\n\n\n9.00-9.15 Welcome9.15-9.45 Jennifer James: Investigating proteome trends: Evolution over huge timescales10.00-10.30 Julia V. Tavares: Forest sensitivity and resilience to climatic and hydrological changes10.45-11.15 Laura Antao: Elucidating biodiversity change in the Anthropocene11.30-12.00 Darrin Schultz: Chromosome structure as an evolutionary ledger URL:https://www.scilifelab.se/event/uppsala-university-ddls-fellows-public-seminars-with-candidates-evolution-and-biodiversity-in-the-light-of-massive-data/ CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240620T120000 DTEND;TZID=Europe/Stockholm:20240620T130000 DTSTAMP:20260404T171137 CREATED:20240102T100557Z LAST-MODIFIED:20240619T094614Z UID:10001097-1718884800-1718888400@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Ivan Tolstoganov DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nIvan Tolstoganov\n\n\n\nKristoffer Sahlin – gamma 6 \n\n\n\nMulti-context seeds enable higher short read mapping accuracy in StrobeAlign \n\n\n\n\n\n\n\n\n\n \n\n\n\n \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-sanem-sariyar-ivan-tolstoganov/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_123412496_HDR2-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240625T150000 DTEND;TZID=Europe/Stockholm:20240625T160000 DTSTAMP:20260404T171137 CREATED:20240527T111108Z LAST-MODIFIED:20240528T075050Z UID:10001267-1719327600-1719331200@www.scilifelab.se SUMMARY:[Spotlight seminar]- Ralf Jungmann DESCRIPTION:Ralf Jungmann\, Professor at Ludwig-Maximilians-Universisty (LMU) and Max-Planck-Institut for Biochemistry\, Germany \n\n\n\nSeminar: Localizomics: towards spatial omics using DNA-based super-resolution microscopy\n\n\n\nI will discuss our group’s vision of converting standard off-the-shelf fluorescence microscopy hardware into a tool for spatial omics. I will introduce technical advancements in DNA-PAINT including approaches that achieve sub-nanometer spatial resolution and spectrally unlimited multiplexing in whole cells. I will then discuss protein labeling probes such as Slow Off-rate Modified Aptamers (SOMAmers) that could allow DNA-barcoded labeling of much of the proteome in a cellular environment. Next\, I present approaches to increase DNA-PAINT’s traditionally slow imaging speeds to achieve throughputs necessary for network-wide molecular interrogation.  Finally\, I will present cell surface receptor quantification at thus far elusive resolutions and levels of multiplexing. \n\n\n\nBio\n\n\n\nRalf Jungmann’s interdisciplinary research is aimed at developing novel imaging tools for biological and biomedical applications. Specifically\, structural and dynamic DNA nanotechnology are combined with single-molecule fluorescence methods. The novel imaging tools unravel position and interplay of genes\, RNAs and proteins in cells in a truly quantitative way with ultrahigh resolving power.Read more: https://www.biochem.mpg.de/jungmann \n\n\n\nHost: Hans Blom\, KTH\, hblom@kth.se URL:https://www.scilifelab.se/event/spotlight-seminar-ralf-jungmann/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240626T102000 DTEND;TZID=Europe/Stockholm:20240626T112000 DTSTAMP:20260404T171137 CREATED:20240312T093603Z LAST-MODIFIED:20240614T152903Z UID:10001201-1719397200-1719400800@www.scilifelab.se SUMMARY:Biodiversitetskrisen hotar hållbarhet och bioekonomi – kan svensk forskning vara lösningen? DESCRIPTION:Planeten vi bebor förändras allt snabbare. Inom kort kan många ikoniska arter vara ett minne blott; ål\, flodkräfta och fjälluggla bland flera andra. Vi måste studera dessa\, för att kunna rädda dem\, innan det är för sent. Hjälp svenska forskare att hjälpa svensk natur! \n\n\n\nTill följd av klimatförändringar och mänsklig påverkan\, förloras biodiversitet och livsviktiga ekosystemtjänster i alarmerande takt. En stor utmaning är nu att förstå konsekvenserna och föreslå motåtgärder. För att möjliggöra detta\, bör arvsmassan från så många arter som möjligt kartläggas. Med detta syfte startades Earth Biogenome Project (EBP) år 2019 för att ge forskare verktyg att kartlägga förlust av mångfald\, rädda hotade arter\, finna nya läkemedel\, och säkerställa födotillgång för världens ökande befolkning. EBP är ett globalt nätverk av nationella och regionala projekt. Sverige är dessvärre ett av få i-länder som ännu inte har ett nationellt delprojekt. Anledningen till detta är att nödvändiga ekonomiska resurser inte avsatts. För att spela en aktiv roll och ta hänsyn till den biologiska mångfalden som kännetecknar vårt land\, behövs strategiskt ekonomiskt stöd. Svenska forskare och forskningsinfrastruktur är redo. Men vem kommer att backa upp oss? \n\n\n\n\n\n\n\nMedverkande\n\n\n\nOlga Vinnere Pettersson\, Scientific Lead of Planetary Biology Capability\, SciLifeLabAndreas Wallberg\, Forskare\, Uppsala UniversitetMats Svensson\, Avdelningchef\, Havs- och vattenmyndighetenCharlotta Berggren\, VVS-konsult\, ByDemandAnna Wetterbom\, Moderator\, SBDI \n\n\n\n\n\n\n\n\n\n\n\nKontakt: \n\n\n\nOlga Vinnere Pettersson\, Uppsala universitet\, Olga.Pettersson@scilifelab.uu.se URL:https://www.scilifelab.se/event/biodiversitetskrisen-och-genetisk-forskning-vad-ar-sveriges-svar/ LOCATION:Yoda Bar & Café\, Skeppsbron 24\, Visby\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/08/Almedalen-2023-2-scaled.jpeg ORGANIZER;CN="SciLifeLab i Almedalen":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240626T130000 DTEND;TZID=Europe/Stockholm:20240626T140000 DTSTAMP:20260404T171137 CREATED:20240312T093837Z LAST-MODIFIED:20240614T152954Z UID:10001202-1719406800-1719410400@www.scilifelab.se SUMMARY:Inför nästa pandemi - hur behåller vi och utvecklar viktig laboratoriekunskap och teknik? DESCRIPTION:Under denna pandemi har vi förbättrat vår förmåga att hantera pandemier\, men hur behåller vi och utvecklar viktig laboratoriekunskap och teknik till nästa pandemi/hälsokris? \n\n\n\nCOVID-19 pandemin har gått in i en post-pandemisk fas men nya pandemier kommer drabba oss. Tidigt under pandemin blev det uppenbart att Sverige hade begränsade resurser att analysera prover från alla potentiellt infekterade\, vilket negativt påverkade möjligheten att kontrollera smittspridningen. En solid\, tillgänglig och högteknologisk plattform saknades för att skapa samarbeten och utbyten mellan sjukhusens mikrobiologiska laboratorier\, akademiska forskare\, och myndigheter. Ny forskning behövdes för att förstå detta nya virus och nya tekniker behövde utvecklas för att kunna följa utvecklingen av och kontrollera pandemin. Därför fick SciLifeLab i slutet av 2020 uppdraget från regeringen att utveckla Pandemisk Laborativ Beredskap\, och har nu byggt upp nationell kapacitet i Sverige för att hantera pandemier och andra biologiska hot framöver. Men är det något som saknas? Hur säkerställer vi att denna kapacitet och kunskap underhålls och utvecklas vidare? Vem ska göra vad? \n\n\n\nMedverkande\n\n\n\nStaffan Svärd\, Professor\, Uppsala Universitet och SciLifeLabUlf Ribacke\, Co-director PLP\, Uppsala Universitet\, SciLIfeLab och Karolinska InstitutetMia Philipson\, Professor och Co-director\, Uppsala Universitet och SciLIfeLabJens Mattsson\, Generaldirektör\, Totalförsvarets forskningsinstitut (FOI)Sara Byfors\, Avdelningschef\, Folkhälsomyndigheten (FoHM)Niklas Arnberg\, Professor och generalsekreterare\, Umeå Universitet och Virus – och pandemifondenBengt Mattson\, Hållbarhetsansvarig\, Lif- de forskande läkemedelsföretagen \n\n\n\n\n\n\n\n\n\n\n\nKontakt: \n\n\n\nAlice Sollazzo\, SciLifeLab\, alice.sollazzo@scilifelab.uu.se URL:https://www.scilifelab.se/event/infor-nasta-pandemi-hur-behaller-vi-och-utvecklar-viktig-laboratoriekunskap-och-teknik/ LOCATION:D-huset\, Campus Gotland\, Kaserngatan 1\, Visby\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/08/Almedalen-2023-2-scaled.jpeg ORGANIZER;CN="SciLifeLab i Almedalen":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240626T160000 DTEND;TZID=Europe/Stockholm:20240626T170000 DTSTAMP:20260404T171137 CREATED:20240312T094238Z LAST-MODIFIED:20240614T153131Z UID:10001203-1719417600-1719421200@www.scilifelab.se SUMMARY:Framtidens hälso- och sjukvård och forskning möjliggörs tack vare europeisk satsning på genomikdata DESCRIPTION:För förbättrad sjukvård (precisionsmedicin) och ökad kunskap om genetisk variation arbetar Europa tillsammans för att ge forskare och läkare tillgång till viktiga genomikdata. Med lagstiftning på hälsodataområdet och säker tillgång till data skapas nya möjligheter för framtidens sjukvård och forskning. \n\n\n\nSeminarium men initiala korta presentationer om de pågående initiativen följt av paneldiskussion och frågor från auditoriet. a) De korta presentationerna kommer att vara kring: i) Det europeiska 1+Million Genome Project\, som Sverige och 23 andra länder är engagerade i. ii) Byggande av en europeisk genomikdatainfrastruktur (GDI) iii) Ny lagstiftning inom hälsodataområdet (EHDS) iv) Precisionsmedicinens möjligheter för medborgare\, patienter och forskare b) Paneldiskussion med företrädare för genomikinfrastrukturen\, sjukvården\, precisionsmedicin\, e-hälsomyndigheten\, patientföreningar och juridisk kompetens. c) Tillfälle för publiken att ställa frågor så att vi får en öppen diskussion med tillfälle till fördjupning. \n\n\n\nMedverkande\n\n\n\nBengt Persson\, Professor i bioinformatik\, Uppsala Univ\, SciLifeLab\, NBIS\, ELIXIRRichard Rosenquist Brandell\, Professor och överläkare i klinisk genetik\, Karolinska Institutet\, Karolinska Universitetssjukhuset\, Genomic Medicine SwedenÅsa Johansson\, Universitetslektor och Vetenskaplig ledare för Precisionsmedicin\, Uppsala Univ\, SciLifeLabManólis Nymark\, Jurist\, European 1+ Million Genome projectMichel Silvestri\, Enhetschef\, med dr\, E-hälsomyndighetenJohan Viklund\, Teknisk chef\, Uppsala Univ\, SciLifeLab\, NBIS\, ELIXIR \n\n\n\nKontakt \n\n\n\nBengt Persson\, Uppsala universitet\, bengt.persson@icm.uu.se URL:https://www.scilifelab.se/event/framtidens-halso-och-sjukvard-och-forskning-mojliggors-tack-vare-europeisk-satsning-pa-genomikdata/ LOCATION:D-huset\, Campus Gotland\, Kaserngatan 1\, Visby\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/08/Almedalen-2023-2-scaled.jpeg ORGANIZER;CN="SciLifeLab i Almedalen":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240627T113000 DTEND;TZID=Europe/Stockholm:20240627T123000 DTSTAMP:20260404T171137 CREATED:20240312T093325Z LAST-MODIFIED:20240614T153257Z UID:10001200-1719487800-1719491400@www.scilifelab.se SUMMARY:Hur kan storskaliga molekylära analyser leda till precisionshälsa? DESCRIPTION:Molekylära analyser kan möjliggöra preventiva insatser\, tidig diagnos och individanpassad behandling. Hur kan vi underlätta införandet av nya teknologier för precisionshälsa i hälso- och sjukvården? Och vilka långsiktiga ekonomiska och hälsomässiga fördelar kan detta ha för samhället? \n\n\n\n\n\n\n\nSverige har en världsunik forskningsinfrastruktur för molekylära analyser och spetskompetens inom dataanalys. Vi har även byggt upp starka nätverk mellan akademi och sjukvårdsregioner för implementering av genetiska analyser i klinisk rutin. Hur kan vi på bästa sätt nyttja och bygga vidare på dessa resurser för att skala upp genereringen av molekylära data inom hälso- och sjukvården? Kan storskaliga molekylära analyser bidra till att hälso- och sjukvården ökar sitt fokus på förebyggande åtgärder och tidig diagnostik? Hur kan vi hitta en modell för att på ett smidigt sätt testa och integrera nya teknologier för precisionshälsa inom vården och vem ansvarar för vad i processen – vad är akademins\, regionernas och industrins roll? \n\n\n\nMedverkande\n\n\n\nAnders Hagfeldt\, rektor\, UUÅsa Johansson\, doc. i molekylär epidemiologi\, UU\, SciLifeLabFrida Lundmark\, sakkunnig policy\, Lif – de forskande läkemedelsföretagenMarie Morell\, ordf. Regionstyrelsen\, Region ÖstergötlandRichard Rosenquist Brandell\, prof. och överläkare i klinisk genetik\, KI\, Karolinska Universitetssjukhuset\, GMSPatrik Rossi\, tf. sjukhusdirektör\, Karolinska UniversitetssjukhusetMia Phillipson\, moderator\, UU\, SciLifeLab \n\n\n\nArrangörsuppgifter:\n\n\n\nKontakt: \n\n\n\nÅsa Johansson\, Uppsala universitet\, SciLifeLab\, Genomic Medicine Sweden\, asa.johansson@igp.uu.se \n\n\n\nEva Berglund\, Uppsala universitet\, SciLifeLab\, eva.berglund@scilifelab.uu.se URL:https://www.scilifelab.se/event/hur-kan-storskaliga-molekylara-analyser-leda-till-precisionshalsa/ LOCATION:D-huset\, Campus Gotland\, Kaserngatan 1\, Visby\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/08/Almedalen-2023-2-scaled.jpeg ORGANIZER;CN="SciLifeLab i Almedalen":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240815T110000 DTEND;TZID=Europe/Stockholm:20240815T114500 DTSTAMP:20260404T171137 CREATED:20240624T140804Z LAST-MODIFIED:20240624T141010Z UID:10001286-1723719600-1723722300@www.scilifelab.se SUMMARY:Calls for new project support from chemical biology and genome engineering platform and the drug discovery & development platform DESCRIPTION:The Chemical Biology and Genome Engineering platform and the Drug discovery and development (DDD) platform at SciLifeLab have calls out for projects support. \n\n\n\nThe Chemical Biology unit looks projects proposals including including assay development\, small molecule screening\, drug profiling\, and medicinal and computational chemistry.  For more information\, please visit www.cbcs.se. \n\n\n\nThe Chemical Biology and Genome Engineering platform are inviting project proposals aiming to explore compounds/drugs mechanism of action that harness the combined strengths of at least two platform units. If approved\, these projects will gain cost-effective access to CBGE’s cutting-edge technologies \n\n\n\nBoth the above welcome proposals in all areas of biology not only in human health. \n\n\n\nThe DDD platform has a call looking for new project proposals for drug discovery. All therapeutic modalities that can be developed in collaboration with the DDD platform at SciLifeLab are of interest\, including small molecules\, antibodies\, oligonucleotides and new modalities. \n\n\n\nSome users and projects are at the intersection between chemical biology and drug discoveryhttps://ki-se.zoom.us/j/61032835991 \n\n\n\nProgram: \n\n\n\n1. Presentation of CBGE offerings \n\n\n\n2. Presentation of the DDDp offerings \n\n\n\n3. Q/A URL:https://www.scilifelab.se/event/calls-for-new-project-support-from-chemical-biology-and-genome-engineering-platform-and-the-drug-discovery-development-platform/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240816T100000 DTEND;TZID=Europe/Stockholm:20240816T110000 DTSTAMP:20260404T171137 CREATED:20240815T084917Z LAST-MODIFIED:20240815T085734Z UID:10001320-1723802400-1723806000@www.scilifelab.se SUMMARY:The protein structure prediction problem: from Anfinsen's hypothesis to AlphaFold and beyond DESCRIPTION:Claudio Mirabello\, NBIS\, Linköping University \n\n\n\nAbstract: Proteins are the tools responsible for most essential functions carried in every organism\, from viruses to mammals. In order to better understand the way a protein works\, it is important to know its three-dimensional structure. In the past few years\, new Machine Learning technologies – neural networks not too dissimilar to those powering ChatGPT – have made it possible to greatly accelerate the process of determination of protein structures by leveraging their evolutionary history. But how do these new technologies work\, how did we get to build tools such as AlphaFold and what comes next? \n\n\n\nNBIS arranges an open AI and IO Seminar Series aimed at knowledge-sharing about Artificial Intelligence and Integrative Omics (AI & IO) analysis and applications in the Life Science community. The seminar series is open to everyone. The seminar is run over Zoom on the third Friday of the month during academic terms\, typically between 10 and 11 am\, with approx. 45 min long presentation and 15 min discussion. URL:https://www.scilifelab.se/event/the-protein-structure-prediction-problem-from-anfinsens-hypothesis-to-alphafold-and-beyond/ LOCATION:Online event via Zoom CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240822T150000 DTEND;TZID=Europe/Stockholm:20240822T160000 DTSTAMP:20260404T171137 CREATED:20240816T140228Z LAST-MODIFIED:20240816T140230Z UID:10001330-1724338800-1724342400@www.scilifelab.se SUMMARY:A tale of two T cells - revealing the innate program of CD8+ T cells by single-cell genomics DESCRIPTION:Dr. Andrew Grimson\, Cornell University CD8+ T cells are classically recognized as adaptive immune cells based on their ability to recognize specific foreign antigens via their T cell receptor (TCR). However\, recent studies indicate that some naive CD8+ T cells can respond to innate cytokines alone in the absence of TCR stimulation\, a phenomenon referred to as bystander activation. Here\, we demonstrate that neonatal CD8+ T cells undergo a robust and diverse program of bystander activation\, which can protect against bacterial\, viral\, and parasitic pathogens in a TCR-independent manner. Using a multi-omics approach\, we found that the innate-like bystander program of neonatal CD8+ T cells is mediated by rapid chromatin remodeling and controlled by a balance of Bach2 and AP-1 transcription factor activity. The innate CD8+ T cell subset that predominates in early life is also present in adult mice and humans\, indicating that multiple layers of defense exist within the adult naïve T cell pool\, a compartment that is more functionally diverse than previously thought. \n\n\n\nBiography \n\n\n\nThe Grimson laboratory investigates gene regulation\, with an emphasis on genomics and gene regulation. It has three areas of emphasis: first\, the application and development of genomics tools\, focusing on the immune system\, second\, the function of small RNA regulatory molecules (chiefly microRNAs\, focusing on their roles in the immune system)\, and third\, the identification and characterization of novel cis- regulatory elements within mRNAs\, and the impact such elements have on regulation of the transcriptome. These research areas represent Andrews long-standing experience and interest in the control of gene expression. As a graduate student\, Andrew investigated the NMD mRNA decay pathway (nonsense-mediated mRNA decay; Anderson lab\, University of Wisconsin-Madison)\, and as a postdoctoral fellow\, he focused on microRNA target prediction and small RNA evolution (Bartel lab\, Whitehead/MIT). In his laboratory at Cornell University\, their work typically combines high-throughput experimental and computational genomics\, together with traditional experimental approaches. Ongoing projects include both fundamental studies in post-transcriptional regulation\, for example: mechanistic characterization of novel regulatory pathways they have found; together with investigations into biological roles for post-transcriptional regulation\, for example: investigating roles for small RNAs in the mammalian immune system. A recurring theme in their work is understanding the mechanisms and consequences of regulation of the transcriptome; over the past five years\, almost all their work in this area has focused on the immune system. Moreover\, several of their previous and current projects leverage single-cell genomics technologies as a primary tool to study immune cell subsets. It is this theme – the interface of genomics and immunology – which is reflected in his role as mentor and sponsor for Connor Kean. URL:https://www.scilifelab.se/event/a-tale-of-two-t-cells-revealing-the-innate-program-of-cd8-t-cells-by-single-cell-genomics/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240823T080000 DTEND;TZID=Europe/Stockholm:20240823T170000 DTSTAMP:20260404T171137 CREATED:20240823T125432Z LAST-MODIFIED:20240823T125517Z UID:10001336-1724400000-1724432400@www.scilifelab.se SUMMARY:CryoEM sample preparation and data collection course DESCRIPTION:The purpose of the course is to prepare and train cryoEM facility users in sample preparation methods\, introduce users to the image data acquisition workflow\, expand knowledge about cryoEM methods among researchers and show that everyone can learn how to use cryoEM for structural biology. \n\n\n\nCourse description\n\n\n\nThe course is open for facility users or potential facility users\, such as PhD students\, postdocs\, and researchers within the life sciences who are curious and will profit from cryoEM skills. Swedish and international course participants are welcome. To attend\, the course participants should be familiar with electron microscopy and structural biology. \n\n\n\nThis course is supported by SciLifeLab\, CryoNET and Umeå University and organized by the Umeå Centre for Electron Microscopy (UCEM). \n\n\n\nRead more\n\n\n\n241204-241206_CryoEM_sample_preparation_2024Download\n\n\n\nApplication deadlineApplication should be submitted before November 1st\, 2024 \n\n\n\nCourse organizersSara SandinTanvir Shaikh \n\n\n\nLocationUCEM and Chemical Biological Centre (KBC) BuildingUmeå UniversityLinnaeus väg 6 \n\n\n\nTeachers and course instructors \n\n\n\n\nLinda Sandblad\n\n\n\nSara Sandin\n\n\n\nTanvir Shaikh\n\n\n\nLars-Anders Carlson\n\n\n\nErin Schexnaydre\n\n\n\nJohan Unge\n\n\n\nAdditional teachers t.b.a\n\n\n\n\nCourse content \n\n\n\nThis course will cover practical aspects of cryoEM sample preparation and data acquisition. \n\n\n\nThe following topics will be covered: \n\n\n\n\nOverview of cryoEM methods\n\n\n\nMicroscope design and electron optics\n\n\n\nSample preparation\n\n\n\nData collection for single particle analysis (SPA)\n\n\n\nIntroduction to SPA image processing\n\n\n\n\nThe course consists of lectures\, cryo lab work\, demonstrations and practical exercises for all participants\, hands-on experiences of microscopy operation and discussions. A detailed schedule will be provided to accepted participants. \n\n\n\nCourse literatureHandouts and material online. \n\n\n\nEntry requirements \n\n\n\nPriority will be given to researchers involved in a project where the use of cryo-EM is needed\, which are to be briefly described upon application. \n\n\n\nThe course is suitable for researchers in the life sciences with a master’s or PhD degree\, including graduate students\, postdocs and staff scientists. \n\n\n\nA maximum of 18 participants will be admitted. Please provide a clear description of your research project and motivation for attending the course. \n\n\n\nExamination Participation in all parts of the course\, lectures\, lab\, microscopy demonstrations and evaluation are mandatory. Upon completion\, SciLifeLab and Umeå University will provide a course certificate and a recommendation for 1 ECTS. URL:https://www.scilifelab.se/event/cryoem-sample-preparation-and-data-collection-course/ LOCATION:KBC Building Umeå\, Linneaus Väg 6\, Umeå CATEGORIES:Course ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/08/241204-241206_CryoEM_sample_preparation_2024.jpg ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240827T120000 DTEND;TZID=Europe/Stockholm:20241001T120000 DTSTAMP:20260404T171137 CREATED:20240615T115304Z LAST-MODIFIED:20240615T115305Z UID:10001278-1724760000-1727784000@www.scilifelab.se SUMMARY:Data-Driven Life Sciences Course 2024 (Online) DESCRIPTION:Welcome to the Data-driven Life Sciences 2024 course\, where you will explore the intersection of data science\, artificial intelligence\, and life sciences to drive innovation and discovery. This fully online course culminates in an in-person hackathon\, fostering a vibrant community that gathers the DDLS and SciLifeLab members. \n\n\n\nThe 6 modules aim to introduce learners to computer-driven life sciences\, covering application areas in data-driven life sciences. Guest lecturers (DDLS Fellows\, SciLifeLab fellows\, and SciLifeLab facility training providers) will teach topics including technologies and analysis of data sets from proteomics\, transcriptomics\, biomolecular structure\, molecular dynamics simulations\, and various imaging techniques. These modules present\, analyze\, and discuss models of biological phenomena and related scientific breakthroughs based on such data analysis. \n\n\n\nRegistration\n\n\n\nAs prerequisites for the course\, we recommend that you have a look at the following resources: \n\n\n\n\nPlease have a look at the SciLifeLab Data-Driven Life Science (DDLS) initiative website to understand what data-driven life sciences are\, and how Sweden is investing in this area. Focus in particular on the concept of the data life cycle\, which is central in this class.\n\n\n\nWe will use Python as the main programming language in the computer lab\, so please make sure you know the basics of Python. \n\n\n\n\nFor the computer lab\, you will need a computer with internet access\, and make sure you have the following set up: \n\n\n\n\nInstall the latest browser\, e.g. Chrome\n\n\n\nRegister a Google account for the Google Colab access and use the Google Drive\n\n\n\nRegister a ChatGPT account (Note: No need to subscribe to the paid version of ChatGPT\, using the free version is sufficient for this course)\n\n\n\nRegister a Github account for versioning of the code\n\n\n\n\nLearning objectives:  \n\n\n\n\nDescribe the field of data-driven life sciences\n\n\n\nPresent an overview of various application areas\n\n\n\nProvide examples of applications and their associated analysis methods\n\n\n\nApply statistical and machine learning analysis to biological data sets\n\n\n\nFormulate models of biological phenomena\n\n\n\nPresent and review scientific literature in computer-driven life sciences\n\n\n\nReflect on the ethical consequences of data-driven life sciences\n\n\n\nPractice good data management\, including collection\, handling\, sharing\, and analysis\n\n\n\n\nFor questions\, contact the course leader Wei Ouyang at weio@kth.se URL:https://www.scilifelab.se/event/data-driven-life-sciences-course-2024-online/ LOCATION:Online event via Zoom CATEGORIES:Course END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240828T100000 DTEND;TZID=Europe/Stockholm:20240828T150000 DTSTAMP:20260404T171137 CREATED:20240419T094002Z LAST-MODIFIED:20240422T112735Z UID:10001236-1724839200-1724857200@www.scilifelab.se SUMMARY:Data Delivery System (DDS) Workshop for Unit Users DESCRIPTION:We invite current and future users of the Data Delivery System (DDS) from SciLifeLab units to join us for a workshop. \n\n\n\nWhen: August 28 in Alfa 2 Milky Way\, SciLifeLab Solna. \n\n\n\nRegister: Register before Aug 23 24.00 \n\n\n\nMax participants: 20 \n\n\n\nThe workshop will include hands-on introductions to registration\, client installation & project access management\, as well as troubleshooting common issues. There will also be a session looking to the future of DDS: future plans and gathering end-user input (e.g. what are the personas amongst your unit’s data recipients?). \n\n\n\nThis workshop is limited to 20 participants and\, we’d love as many SciLifeLab units as possible to be represented\, so would really appreciate you coordinating within your unit to decide who should attend. If there is sufficient demand\, this workshop will run again in the future. \n\n\n\nRegister\n\n\n\nPractical Information\n\n\n\nThe workshop will take place in-person at the SciLifeLab Solna campus. Participants must bring their own laptops for the hands-on component of the day. Lunch will be provided ( if you have dietary restrictions please note this in the registration) \n\n\n\nPreliminary Agenda\n\n\n\n09:30-10:00Fika10:00-10:10Welcome & practical info10:10-10:25Intro to DDS 10:30-12:00Registration\, client installation & project access12:00-13:00Lunch13:00-13:45Project life cycle & support14:00-15:00Future development & user input\n\n\n\nContact information\n\n\n\n\nFor questions contact the Data Delivery System team at SciLifeLab Data Centre. Contact person: Aishling Cooke\n\n\n\nEmail: delivery@scilifelab.se URL:https://www.scilifelab.se/event/dds-workshop-for-unit-users/ LOCATION:SciLifeLab Campus Solna\, Tomtebodavägen 23 A\, Solna\, Sweden CATEGORIES:Course ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/04/Skarmavbild-2024-04-19-kl.-11.30.56-1.png ORGANIZER;CN="SciLifeLab Data Centre":MAILTO:datacentre@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240829T090000 DTEND;TZID=Europe/Stockholm:20240830T170000 DTSTAMP:20260404T171137 CREATED:20240529T151739Z LAST-MODIFIED:20240715T101009Z UID:10001271-1724922000-1725037200@www.scilifelab.se SUMMARY:Sixth SWACCS Junior Academy Workshop (JAWS) DESCRIPTION:JAWS is a workshop organized by the Swedish Academic Consortium on Chemical Safety (SWACCS)\, Stockholm University and Karolinska Institutet for PhD students\, master students\, postdocs and researchers working in all fields related to chemicals\, health and the environment. We’re offering exciting presentations\, great networking opportunities\, and a workshop on how to write a press release for your own research. Also\, join us one day early (on August 28th) and be part of the SWACCS Regulatory Toxicology II course’s concept mapping workshop\, where you can learn more about the various kinds of scientific evidence being used by different organizations in society and how these sectors interact and collaborate with one another to reach the goal of a chemical safe future. \n\n\n\nContact \n\n\n\nSolveig Thielesolveig.thiele@scilifelab.se \n\n\n\n \n\n\n\nAugust 29 \n\n\n\n\nPresentations and perspectives on the topic “Can you be a scientist and an activist at the same time – how to reach out with your science in a non-academic way?”\n\n\n\nDinner (potential charge of 200 kr) \n\n\n\n\nAugust 30 \n\n\n\n\nWorkshop – “Reaching a broader audience with your research and learning how to write a press release.” Present and discuss your research with the other participants!\n\n\n\nMingle\n\n\n\n\nWe can only offer a limited number of spots\, so be quick to register. PhD students will be prioritized. Participants can earn credits for this workshop. URL:https://www.scilifelab.se/event/sixth-swaccs-junior-academy-workshop-jaws/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="Swedish Academic Consortium on Chemical Safety (SWACCS)":MAILTO:solveig.thiele@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240829T110000 DTEND;TZID=Europe/Stockholm:20240830T134500 DTSTAMP:20260404T171137 CREATED:20240712T114659Z LAST-MODIFIED:20240829T072610Z UID:10001309-1724929200-1725025500@www.scilifelab.se SUMMARY:Pandemic Laboratory Preparedness Retreat 2024 DESCRIPTION:The SciLifeLab Pandemic Laboratory Preparedness (PLP) program\, started in 2021\, acts to meet society’s need for efficient use of resources\, training and education\, to propagate skills and setting up technologies and equipment to be better equipped for new pandemics. \n\n\n\nThe PLP-retreat aims at strengthening the PLP network as well as an opportunity to highlight and discuss how the PLP program can evolve and be sustainable in the future. \n\n\n\nWith a poster session and focused group discussions on the key questions for pandemic preparedness\, we believe this will be a highly rewarding event for the participants\, and will spur many new ideas on how pandemic preparedness can be structured in the future.   For PLP members and collaborators onlyThe program below will be continuously uppdated \n\n\n\nThursday\, August 29\n\n\n\n11:00Bus departure from SciLifeLab Uppsala/BMC Bus departure from SciLifeLab Solna Bus departure from Stockholm City Terminal (Gate 5)11:15Bus departure from Arlanda From outside terminal 4 (map)11:45LunchAronsborg12:30Plenary PresentationsStockholmsalenChair: Jessica Alm\, Karolinska Institutet12:30Welcome and Introduction Jessica Alm\, Karolinska Institutet12:40SciLifeLab Pandemic Laboratory Preparedness CapabilityStaffan Svärd\, Uppsala University13:00Evaluation of large-scale testing and contact tracing during the pandemic for better preparednessSara Byfors\, Swedish Public Health Agency13:20Short Break13:40Pandemic vaccination: how should we do it next time?Helena Hervius Askling\, Karolinska Institutet14:00Discussion: Prospective about MpoxSara Byfors\, Swedish Public Health AgencyHelena Hervius Askling\, Karolinska InstitutetAntonio Gigliotti Rothfuchs\, Karolinska Institutet14:20Preparedness for human biomonitoring – a toxicologists viewMattias Öberg\, Karolinska Institutet14:40Coffee Break15:10Flash TalksModerated by Peter Nilsson\, KTH16:20Who is the PLP master?Ulf Ribacke\, Karolinska Institutet16:50Concluding Remarks\, poster hanging and check-in to hotel18:00Mingle and Poster SessionUpplandssalen19:00Dinner21:00After Dinner MingleCrillo\n\n\n\n \n\n\n\n \n\n\n\nFriday\, August 30\n\n\n\n08:45Check out from hotel09:00Plenary PresentationsUpplandssalenChair: Staffan Svärd\, Uppsala University09:05What to expect when you’re not expectingBill Hanage\, Harvard University\, USA09:30Investigating the evolution of  panzootic H5N1 in mammalsThomas Peacock\, Pirbright Institute\, UK10:00Short Break10:15Pandrug-resistant gram-negative bacteria in Ukraine  – will they spread beyond hospitals?Kristian Riesbeck\, Lund University10:45Group Discussion IntroductionsStaffan Svärd\, Uppsala University10:50Coffee Break and Group Discussions12:00Group Discussion Summary in plenary; 1-2 min per groupModerator Staffan Svärd\, Uppsala University12:35Wrap-Up and taking down the posters12:40Bus Transfer to Arlanda Airport Brown paper bag-lunch to go.12:45Lunch13:45Bus Transfer to Stockholm City Terminal (via SciLifeLab Campus Solna) Bus Transfer to SciLifeLab Uppsala/BMC \n\n\n\n \n\n\n\n\n\nScientific Committee\n\n\n\nThe program has been developed by the Scientific committee. \n\n\n\n\nStaffan Svärd\, PLP Scientific lead\, Uppsala University \n\n\n\nUlf Ribacke\, PLP Scientific co-lead\, Karolinska Institutet & Uppsala University  \n\n\n\nJessica Alm\, Karolinska Institutet  \n\n\n\nPeter Nilsson\, KTH;\n\n\n\nDaniel Sheward\, Karolinska Institutet\n\n\n\nAlice Sollazzo\, Coordinator PLP-Program at SciLifeLab\, Alice.sollazzo@scilifelab.uu.se URL:https://www.scilifelab.se/event/plp-retreat-2024/ LOCATION:Aronsborg Konferenshotell\, Helgövägen 7\, Bålsta\, 746 30 CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/PLP_main.jpg ORGANIZER;CN="Pandemic Laboratory Preparedness at SciLifeLab":MAILTO:alice.sollazzo@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240829T120000 DTEND;TZID=Europe/Stockholm:20240829T130000 DTSTAMP:20260404T171137 CREATED:20240708T134205Z LAST-MODIFIED:20240819T084728Z UID:10001293-1724932800-1724936400@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Jianyu Shen & Riccardo Mosca DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nJianyu Shen\n\n\n\nThomas Helleday – alpha 5 \n\n\n\nConverting Cold into Hot Tumors by Mitotic MTH1 Inhibitor TH1579 Treatment \n\n\n\n\n\nRiccardo Mosca\n\n\n\nClaudia Kutter – gamma 5 \n\n\n\nDeciphering riboregulation in healthy and disease \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-jianyu-shen-riccardo-mosca/ LOCATION:Milkyway SciLifeLab Solna\, Tomtebodavägen 23\, Solna CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/12/IMG_4110-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240902T080000 DTEND;TZID=Europe/Stockholm:20240905T170000 DTSTAMP:20260404T171137 CREATED:20240826T143600Z LAST-MODIFIED:20240828T134939Z UID:10001338-1725264000-1725555600@www.scilifelab.se SUMMARY:Integrated Structural Biology - Open Lectures at Campus Solna DESCRIPTION:You are welcome to attend any or all of the open lectures and presentations that are part of the 2024 Integrated Structural Biology course\, taking place from September 2-5 at Campus Solna’s Air & Fire venue. \n\n\n\nThese lectures are open to all researchers at SciLifeLab. No registration is required—simply join us at Air & Fire during the scheduled sessions to participate. \n\n\n\nMonday September 2\, 2024 \n\n\n\n14:00-16:00\, Crystallography by Esko Oksanen\, instrument scientist at the European Spallation Source (ESS) \n\n\n\n16:00-17:00\, Project presentation from previous students\, Julia Kinsolving\, Nour Aldin Kahlous and ​Szabolcs Bódizs \n\n\n\n18:00 Student poster session and mingle – pub is open \n\n\n\nWednesday September 4\, 2024 \n\n\n\n9:00-12:00\, Cryo-EM lectures by Tim Schulte\, Stockholm University and Marta Carroni\, Stockholm University. \n\n\n\nThursday September 5\, 2024 \n\n\n\n09:30-10:30\, Computational aspects​ of structural biology\, lecture by Erik Lindahl\, Stockholm University \n\n\n\n11:00-12:00\, Scientific presentations by Marta Bonasconi\, Stockholm University and John Cowgill\, Stockholm University \n\n\n\n13:00-14:00\, Biophysical characterization by Maria Sunnerhagen\, Linköping University and ProLinC \n\n\n\n14:00-14.45\, Drug Discovery and Development platform\, by Esmeralda Woersternek\, Karolinska Institutet URL:https://www.scilifelab.se/event/integrated-structural-biology-open-lectures-at-campus-solna/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Community ORGANIZER;CN="InfraLife":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240902T080000 DTEND;TZID=Europe/Stockholm:20240913T170000 DTSTAMP:20260404T171137 CREATED:20240402T105825Z LAST-MODIFIED:20240604T091422Z UID:10001222-1725264000-1726246800@www.scilifelab.se SUMMARY:Integrated Structural Biology course 2024 DESCRIPTION:Welcome to the Integrated Structural Biology course\, 2nd edition \n\n\n\nOrganized by SciLifeLab in collaboration with PPS (Protein Production Sweden)\, ESS (European Spallation Source)\, MAX IV\, ProLinC\, NSC (National Supercomputer Centre)\, SwedNMR and InfraLife. \n\n\n\nSeptember 2-13 in Stockholm\, Linköping\, Lund and Gothenburg \n\n\n\nQuestions regarding the course? Send them to: cecilia.persson@nmr.gu.se. \n\n\n\napply here!\n\n\n\nThis course guides you through the different available techniques within structural biology at infrastructures in Sweden. We will also guide all participants through Sweden\, showcasing several of the infrastructures. In short\, the following techniques will be addressed: \n\n\n\n\nCryo-EM\n\n\n\nNMR\n\n\n\nStructural proteomics\n\n\n\nCrystallography\n\n\n\nSAXS/SANS\n\n\n\nBiophysical characterization\n\n\n\nComputational aspects including AlphaFold\n\n\n\nProtein production\n\n\n\nStudent presentations\n\n\n\nSite visits\n\n\n\n\nThe course will start with 4 days in Stockholm and then finish the first week in Linköping. Second week starts in Lund and finishes with two days in Gothenburg. \n\n\n\nYou can download the course overview here: \n\n\n\n Preliminary schedule pdf. \n\n\n\nThere is a course fee for academic participants of 6000 SEK that includes lodging (4 nights each week)\, meals all days and travel between sites. Industry and healthcare participants are welcome for full or specific day participation. Contact Cecilia for more information about costs depending on degree of participation. Industry also welcome to sponsor part of the event and get exposure and networking possibility. \n\n\n\nTravels between sites will be organized for all as well as lodging and lunch/fika. Participants are asked to arrange their own travels to Stockholm on September 2 (arrival latest at 10)\, from Linköping on September 6\, travel to Lund (arrival September 9 before lunch) and then again final travel home on September 13. \n\n\n\nImportant dates\n\n\n\nThere are still some places left in the course and we have prolonged the last application date so you can apply until June 20\, and we will let you know shortly after if you have secured a place in the course \n\n\n\n \n\n\n\nTeachers\n\n\n\n\nMartin Moche\n\n\n\nTomas Nyman\n\n\n\nEsko Oksanen\n\n\n\nTim Schulte\n\n\n\nMichael Hall\n\n\n\nHanna Barriga\n\n\n\nDean Derbyshire\n\n\n\nMaria Sunnerhagen\n\n\n\nSimon Ekström\n\n\n\nLotta Happonen\n\n\n\nCaludio Mirabello\n\n\n\nWojciech Potrzebowski URL:https://www.scilifelab.se/event/integrated-structural-biology-course-2024/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Course ORGANIZER;CN="Integrated Structural Biology Platform at SciLifeLab":MAILTO:cecilia.persson@nmr.gu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240902T151500 DTEND;TZID=Europe/Stockholm:20240902T161500 DTSTAMP:20260404T171137 CREATED:20240819T072902Z LAST-MODIFIED:20240819T160502Z UID:10001308-1725290100-1725293700@www.scilifelab.se SUMMARY:[The Svedberg seminar] - The Genomic War Between the Sexes DESCRIPTION:Mark A KirkpatrickProfessorUniversity of Texas\, USA \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nMark received an undergraduate degree at Harvard and Ph.D. at the University of Washington with Monty Slatkin.  Following a Miller Fellowship at Berkeley\, he took a post at the University of Texas and has remained there since.  Mark was elected as Fellow of the American Association of Arts and Sciences in 2008 and Member of the National Academy of Sciences in 2020. \n\n\n\n \n\n\n\nThe Genomic War Between the Sexes\n\n\n\nSexually antagonistic selection (SAS)\, which occurs when different alleles are favored in females and males.  While SAS is key to many key evolutionary processes\, its prevalence in the genome is largely unknown.  We use a new method to show that SAS acts on a very large number of sites across the human genome.  It contributes to human mortality\, and involves tradeoffs between survival and fecundity that work in converse ways in females and males.  In nonhuman animals\, SAS may be important to determining the sex ratio\, and to the origin and subsequent evolution of sex chromosomes. \n\n\n\nRead more: https://kirkpatricklab.org/ \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nHost: Leif Andersson leif.andersson@imbim.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-mark-kirkpatrick/ LOCATION:BMC Room C4:301\, Husargatan 3\, entrance C1\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240903T120000 DTEND;TZID=Europe/Stockholm:20240903T170000 DTSTAMP:20260404T171137 CREATED:20240326T150717Z LAST-MODIFIED:20240828T141641Z UID:10001217-1725364800-1725382800@www.scilifelab.se SUMMARY:Clinical Genomics Uppsala - Celebrating 10 years of translational research  DESCRIPTION:Clinical Genomics Uppsala invites you to a half-day symposium to celebrate 10 years of translational research – Past achievements and future opportunities in precision medicine \n\n\n\nPlease join us for: \n\n\n\n\nPresentations of projects carried out at Clinical Genomics Uppsala and their clinical implications\n\n\n\n\n\nDiscussion on the present and future of precision medicine and diagnostics\n\n\n\n\n\nMeet old and new friends during a light lunch\, coffee break and mingle celebration\n\n\n\n\n\n\n\n\nWelcome! \n\n\n\nRegistration\n\n\n\nRegistration has closed! \n\n\n\nIn the unfortunate case that you need to cancel\, please email events(at)scilifelab.se as soon as possible to avoid food waste and enable someone else to attend. \n\n\n\n\n\n\n\nProgram\n\n\n\n12:00Lunch and mingle outside the Rudbeck hall (Lennart Nilsson hall)13:00Welcome – Malin Melin and Panagiotis Baliakas\, CGU13:10Clinical Genomics and Genomic Medicine Sweden – Richard Rosenquist Brandell\, KI and Lucia Cavelier\, KI13:30Comprehensive genomic profiling in endocrine tumors – Joakim Crona\, UU13:45Genetic changes over disease progression in mantle cell lymphoma – how can this help us treat patients better? – Ingrid Glimelius\, UU14:00Molecular prognostication of myelodysplastic syndromes – Eva Hellström Lindberg\, KI14:15Diagnostics during the pandemic – Johan Lindh\, UU14:30Coffee Break15:00Immune profiling in cancer patients treated with LOAd703\, an immunostimulatory adenoviral genetherapy – Tanja Lövgren\, UU15:15Novel approaches for ultrasensitive variant detection- Ulf Landegren\, UU15:30Polygenetic risk scores in familial breast cancer – Daniel Eriksson\, UU15:45Future precision diagnostics in hematological cancers – Panagiotis Baliakas\, UU16:00Panel discussion on the future of precision medicine/precision diagnostics(Panel: Lucia Cavelier\, Richard Rosenquist Brandell\, Panagiotis Baliakas\, Eva Tiensuu Janson\, Björn Arvidsson)16:30Concluding remarks16:40Mingle outside the Rudbeck hall (Lennart Nilsson hall) URL:https://www.scilifelab.se/event/clinical-genomics-uppsala-celebrating-10-years-of-translational-research/ LOCATION:Rudbecksalen\, Rudbecklaboratoriet\, Dag Hammarskjöldsväg 20\, Uppsala\, 75237 CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/03/Hemsida-Rudbeck-frontbild.jpeg ORGANIZER;CN="Clinical Genomics Uppsala":MAILTO:clinicalgenomicsuppsala@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240905T120000 DTEND;TZID=Europe/Stockholm:20240905T130000 DTSTAMP:20260404T171137 CREATED:20240708T135457Z LAST-MODIFIED:20240820T110522Z UID:10001294-1725537600-1725541200@www.scilifelab.se SUMMARY:Campus Solna Seminar Series: Solène Frapard & Hower Lee DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 20 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nPhD students that are attending the Campus Solna Seminar lectures will have the opportunity to gain credits. For the syllabus and instructions on how to obtain these credits\, read this document. Please contact your own department at your host University to confirm.See here the full schedule for this semester. \n\n\n\nThis week:\n\n\n\n\n\n\nSolène Frapard\n\n\n\nStefania Giacomello – alpha 3 \n\n\n\nUnderstanding the impact of spaceflight on mouse brain using spatial multiomics methods \n\n\n\n\n\nHower Lee\n\n\n\nMats Nilsson – gamma 4 \n\n\n\nNext generation targeted in situ sequencing \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page. URL:https://www.scilifelab.se/event/campus-solna-seminar-series-solene-frapard-hower-lee/ LOCATION:Milkyway SciLifeLab Solna\, Tomtebodavägen 23\, Solna CATEGORIES:Community ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_124630107_HDR-scaled.jpg ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240909T151500 DTEND;TZID=Europe/Stockholm:20240909T161500 DTSTAMP:20260404T171137 CREATED:20240827T151248Z LAST-MODIFIED:20240827T151324Z UID:10001339-1725894900-1725898500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Designing brighter dyes for advanced fluorescence microscopy and beyond DESCRIPTION:Luke D. LavisHead of Molecular Tools and ImagingHoward Hughes Medical Institute\, USA \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nLuke D. Lavis received his B.S. in Chemistry from Oregon State University in 2000 and his Ph.D. in Organic Chemistry from the University of Wisconsin–Madison in 2008. Circumventing a traditional postdoc\, he than began his independent career as a Group Leader at the Howard Hughes Medical Institute’s Janelia Research Campus\, and was promoted to Senior Group Leader and Head of Molecular Tools and Imaging in 2017. His research focuses on designing small-molecule tools for imaging\, leading to the development of the widely used Janelia Fluor® dyes and the founding of Eikon Therapeutics in 2019. \n\n\n\n \n\n\n\nDesigning brighter dyes for advanced fluorescence microscopy and beyond\n\n\n\nSpecific labeling of biomolecules with bright\, photostable fluorophores is the keystone of fluorescence microscopy. An established method to label cellular components utilizes genetically encoded self-labeling tags\, which enable the attachment of chemical fluorophores to specific proteins inside living cells. For the last decade\, our laboratory has focused on the development of improved fluorophores for use in living systems. We discovered a simple structural modification to classic fluorophores—incorporation of a four-membered azetidine ring—that substantially improves quantum efficiency and photostability. This strategy is generalizable to fluorophores from different structural classes and has yielded a palette of optimized chemical dyes for use in advanced microscopy experiments ranging from single-molecule tracking in individual cells to population voltage imaging in vivo. \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nHost: Daniel Fürth furth@scilifelab.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-luke-lavis/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240910T151500 DTEND;TZID=Europe/Stockholm:20240910T160000 DTSTAMP:20260404T171137 CREATED:20240902T072833Z LAST-MODIFIED:20240902T074501Z UID:10001343-1725981300-1725984000@www.scilifelab.se SUMMARY:[Spotlight seminar] - Designing brighter dyes for advanced fluorescence microscopy and beyond DESCRIPTION:Dr. Luke D. Lavis\, Howard Hughes Medical Institute\, USA  \n\n\n\nBiography\n\n\n\n Luke D. Lavis received his B.S. in Chemistry from Oregon State University in 2000 and his Ph.D. in Organic Chemistry from the University of Wisconsin–Madison in 2008. Circumventing a traditional postdoc\, he than began his independent career as a Group Leader at the Howard Hughes Medical Institute’s Janelia Research Campus\, and was promoted to Senior Group Leader and Head of Molecular Tools and Imaging in 2017. His research focuses on designing small-molecule tools for imaging\, leading to the development of the widely used Janelia Fluor® dyes and the founding of Eikon Therapeutics in 2019. \n\n\n\nAbstract\n\n\n\nSpecific labeling of biomolecules with bright\, photostable fluorophores is the keystone of fluorescence microscopy. An established method to label cellular components utilizes genetically encoded self-labeling tags\, which enable the attachment of chemical fluorophores to specific proteins inside living cells. For the last decade\, our laboratory has focused on the development of improved fluorophores for use in living systems. We discovered a simple structural modification to classic fluorophores—incorporation of a four-membered azetidine ring—that substantially improves quantum efficiency and photostability. This strategy is generalizable to fluorophores from different structural classes and has yielded a palette of optimized chemical dyes for use in advanced microscopy experiments ranging from single-molecule tracking in individual cells to population voltage imaging in vivo. \n\n\n\nHost: Simon Elsässer\, KI\, simon.elsasser@scilifelab.se URL:https://www.scilifelab.se/event/spotlight-seminar-designing-brighter-dyes-for-advanced-fluorescence-microscopy-and-beyond/ LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240911T090000 DTEND;TZID=Europe/Stockholm:20240912T123000 DTSTAMP:20260404T171137 CREATED:20240319T140810Z LAST-MODIFIED:20240906T133615Z UID:10001210-1726045200-1726144200@www.scilifelab.se SUMMARY:Linköping Ion Channel Meeting DESCRIPTION:Welcome to the first Linköping Ion Channel Meeting \n\n\n\nLinköping University hosts some of Sweden’s most successful ion-channel investigators and the national high-throughput electrophysiology core facility. To celebrate our passion for cutting-edge ion-channel research\, we are together with Sophion Biosciences A/S and SciLifeLab launching Linköping Ion Channel Meeting.  \n\n\n\nWe have gathered a line-up of distinguished academic speakers from Europe for a two-day meeting. We will delve into electrophysiology\, with a focus on ion channels. The meeting will also offer room for discussions and connecting with familiar and new colleagues. \n\n\n\n \n\n\n\nVenue: Hugo Theorell salen\, Hus 440\, Plan 9. University Hospital Campus\, Linköping University. Link Maze map \n\n\n\nOrganizing committee \n\n\n\n\nFredrik Elinder\, Linköping University\, SciLifeLab Linköping\n\n\n\nNina Ottosson\, Linköping University\, SciLifeLab Linköping\n\n\n\nJosefine Sandström\, Linköping University\, SciLifeLab Linköping\n\n\n\nAntonios Pantazis\, Linköping University\n\n\n\nDuncan Jarman\, Sophion Bioscience\n\n\n\nRafael Nisenbaum\, Sophion Bioscience\n\n\n\n\nInvited Speakers\n\n\n\n\nAlicia Lundby\, Copenhagen University\, Denmark\n\n\n\nAnna Moroni\, University of Milan\, Italy\n\n\n\nBo Bentzen\, Copenhagen University\, Denmark\n\n\n\nEric Lindahl\, Stockholm University\, Sweden\n\n\n\nKirstine Calloe\, Rigshospitalet\, Denmark\n\n\n\nKlaus Benndorf\, University Hospital Jena\, Germany\n\n\n\nMarta Campiglio\, Innsbruck University\, Austria\n\n\n\nMichael Pusch\, Institute of Biophysics\, CNR\, Genoa\, Italy\n\n\n\nPeter Larsson\, Linköping University\, Sweden\n\n\n\nPeter McNaughton\, King’s College London\, United Kingdom\n\n\n\nRalf Hausmann\, Aachen University\, Germany\n\n\n\nSara Liin\, Linköping University\, Sweden\n\n\n\nThomas Jepps\, Copenhagen University\, Denmark\n\n\n\nThomas Voets\, KU Leuven\, Belgium\n\n\n\nTimothy Lynagh\, University of Bergen\, Norway\n\n\n\nWilliam Brackenbury\, University of York\, United Kingdom\n\n\n\n\nRegistration\n\n\n\nRegistration deadline is August 27\, 2024\, at 12 am. No daily or partial registration fee is available. \n\n\n\nRegistration fee 1500 SEK. The participant adds the invoice address to the online registration form. \n\n\n\nRegister here\n\n\n\nProgram\n\n\n\nAgenda LICM 2024-08-30 (final)Download\n\n\n\nAccommodation\n\n\n\nWe recommend Quality Hotel Ekoxen. A five-minute walking distance from meeting location Map to Quality Hotel Ekoxen \n\n\n\nUse this link when booking Quality Hotel Ekoxen. \n\n\n\nHotel Slottsparken and Elite Stora Hotellet are two other great options for accommodation. \n\n\n\nMeals\n\n\n\nThe registration fee includes two lunches\, regular coffee breaks\, and a three-course dinner. Allergies and dietary requests are added by participants and invited speakers in the registration form. Dinner location \n\n\n\nPoster information\n\n\n\nParticipants are encouraged to present posters. The recommended poster format is Portrait with a maximum width of 78 cm. A scientific committee will suggest some selected posters for oral presentations. \n\n\n\nImportant! To be considered for an oral presentation\, submit Poster information\, including title and abstract\, before August 9. The deadline for poster registration is August 27. The information will be added to a meeting booklet. \n\n\n\nPoster submission URL:https://www.scilifelab.se/event/linkoping-ion-channel-meeting/ LOCATION:University Hospital Campus\, Linköping University\, Universitetssjukhuset\, Linköping\, 581 85\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/04/Ovre-banner-med-loggor-i-vitt.jpg ORGANIZER;CN="SciLifeLab Link%C3%B6ping":MAILTO:linkoping@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240912T090000 DTEND;TZID=Europe/Stockholm:20240912T170000 DTSTAMP:20260404T171137 CREATED:20240529T094337Z LAST-MODIFIED:20240912T065628Z UID:10001266-1726131600-1726160400@www.scilifelab.se SUMMARY:SciLifeLab Campus Solna Science Talks 2024 DESCRIPTION:We would like to warmly welcome you to take part in this year’s Campus Solna Science Talks symposium on September 12th – a meeting for everyone in the community to learn more about ongoing research and activities at SciLifeLab’s Campus Solna\, which aims to bring the community together\, inspire exchange and new collaborations. \n\n\n\nregister today\n\n\n\nResearch presentations will be given by group leaders and junior researchers (selected with consideration for balance in topics\, presenters’ career stages\, and affiliations) as part of four plenary sessions that will be mixed with poster sessions\, panel discussions and a few surprises. \n\n\n\nWe invite all Campus Solna research groups to be represented with at least 1 poster (and maximum 3). Furthermore\, we want to encourage all infrastructure units\, support functions (IT\, OO\, Site support) and committees (DEI\, Public Engagement\, CSI and the PhD&Postdoc Council) to partake with posters! \n\n\n\nProgram\n08:30Arrival\, registration and coffeeLife City\, Solnavägen 3H09:00Welcome and opening of symposiumPer Ljungdahl and Jan Ellenberg09.15Session 1: Immunology in health and diseaseChair: Adnane Achour09.20Using a cell-type centric approach for vascular disease risk profilingLynn Butler 09.35Characterization of NK cell receptor orchestration at the immunological synapsePatrick Ross09.50Towards computationally-optimised immunotherapyLuca Panconi10.05Session wrap-up10:10Coffee\, Speakers’ corner & Poster session10:50Session 2: Tackling cancer: From omics data over system models to drug designChair: María Bueno Alvez10.55Spatial VDJ and immune response in cancer Kim Thrane11.10Deep learning models of cancer mechanismsAvlant Nilsson11.25Protein structure prediction\, interactions\, and universal binder designPatrick Bryant11.40Session wrap-up11.45Leg stretch11:50Panel discussion: Science beyond impact factorModerators: Niclas Jareborg & Isolde PalomboPanelists: Annika Jenmalm Jensen\, Ylva Engström\, Andrea Fossati\, Anniina Vihervaara12:20Lunch\, Speakers’ corner & Poster session13.40Session 3: Environmental impacts on molecular systemsChair: Bénilde Bonnefille13.45Metabolic versatility and switch mechanisms of sulfur bacteria in oxygen minimum zones of Baltic Sea\, Saravana Kumar14.00Epigenetic Transgenerational Effects of Environmental Pollution: Assessing the Impact of the Herbicide Linuron on Xenopus tropicalis FrogsMauricio Roza14.15Chemical Exposomics in a Longitudinal Swedish Wellness Cohort (S3WP)Kalliroi Sdougkou14.30Session wrap-up14.35Coffee\, Speakers’ corner & Poster session15.05Session 4: Mining\, molecular profiling and analysesChair: Olena Berkovska15:10Charting the human immune landscape across development and diseaseBurcu Ayoğlu15.25Mining for novel microproteins involved in tumor epithelial-mesenchymal balanceAlberto M. Arenas Molina15.40A human pan-disease blood atlas based on next generation blood profilingMaria Bueno Alvez15.55Session wrap-up16.00Leg stretch and poster demounting16.10Panel discussion: Campus Solna future Directions and Collaborative Opportunities Moderators: Iskra Pollak Dorocic & Per LjungdahlPanelists: Claudia Fredolini\, Jessica Lindvall\, Patrick Bryant\, Eva Brinkman\, Carsten Daub16.45Concluding remarksPer Ljungdahl17.00Pub at Campus Solna\n\n\n\n\nPosters\nEach group/unit is welcome to bring up to 3 posters to the grand Poster Session that will follow the talks. Submit the poster titles in the registration form. Please coordinate within your research group/unit beforehand who should bring a poster. \n\n\n\nPlease add your building and floor to the poster\, so that everyone knows where your research is taking place. \n\n\n\nPoster size; A0 or smaller \n\n\n\nPoster list Science Talks 2024Download\n\n\n\n\nBreak activities\nRoomOrganiserDescriptionFutureCoaching in Science InitiativeRelax and Recharge – Guided Meditation Sessions with the Coaching in Science InitiativeWarmly welcome to visit the Coaching in Science Initiative (CSI). Here\, we will provide a break and an opportunity to relax. Join us for a guided meditation\, body scan with nature sounds\, and other relaxation techniques. In the future\, we are exploring arranging weekly such events at SciLifeLab in Solna.CreativePhD and postdoc council at Campus SolnaFrom SciLifeLab for SciLifeLabMeet and discuss with the members of the PhD and postdoc council about ongoing initiatives\, challenges at Campus Solna and your ideas for a better community!EvolutionSciLifeLab Events and CommunicationShowcasing the Beauty of Science – Art at Campus SolnaAt SciLifeLab’s Solna campus\, we’re discovering that science and art aren’t as different as they might seem. Our researchers\, who are dedicated to advancing knowledge\, often create stunning visual art through their scientific work. These images\, rooted in research\, showcase the inherent beauty in scientific discovery\n\n\n\n\nScientific Committee\nThis event has been made possible through the hard work of the Scientific committee. \n\n\n\nScientific Committee \n\n\n\n\nAdnane Achour\n\n\n\nMarcel Tarbier\n\n\n\nIskra Pollack Dorocic\n\n\n\nHaris Babacic\n\n\n\nPer Ljungdahl\n\n\n\n\nOperations Office representatives \n\n\n\n\nIsolde Palombo\n\n\n\nDisa Larsson Hammarlöf URL:https://www.scilifelab.se/event/scilifelab-campus-solna-science-talks-2024/ LOCATION:Life City\, Solnavägen 3H\, Stockholm\, 113 64 CATEGORIES:Community ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240916T080000 DTEND;TZID=Europe/Stockholm:20240920T170000 DTSTAMP:20260404T171137 CREATED:20240426T103029Z LAST-MODIFIED:20240426T103031Z UID:10001243-1726473600-1726851600@www.scilifelab.se SUMMARY:Epigenomics Data Analysis: from Bulk to Single Cell – ONLINE DESCRIPTION:National course open for PhD students\, postdocs\, researchers and other employees in all Swedish universities\, in need of  Epigenomics data analysis skills. We also welcome applications from outside of Sweden and from the non-academic sector\, for more info contact us! \n\n\n\nImportant dates and information\n\n\n\nApplication opens: 2024-04-26 \n\n\n\nApplication closes: 2024-08-28 \n\n\n\nConfirmation to accepted students: 2024-08-30 \n\n\n\nCourse Leaders : Agata Smialowska and Louella Vasquez \n\n\n\nContact information:  edu.epigenomics@nbis.se \n\n\n\nCourse fee\n\n\n\nThis online training event has no fee for academic participants. However\, if you accept a position at the workshop and do not participate (no-show) you will be invoiced 2 000 SEK. For non-academic participants a course fee* of 12 000 SEK  will be invoiced. \n\n\n\n*Please note that NBIS cannot invoice individuals \n\n\n\nCourse content\n\n\n\nThis workshop aims to introduce the best practice bioinformatics methods for processing\, analyses\, visualisation and integration of epigenomics and functional genomics data. \n\n\n\nTopics covered include: \n\n\n\n\nData processing and analyses for differential DNA methylation with Illumina EPIC arrays and Bisulfite-seq;\n\n\n\nChIP-seq: peak calling\, peak independent / dependent quality metrics\, differential binding analysis; DNA motif enrichment;\n\n\n\nATAC-seq: peak calling\, peak independent / dependent quality metrics\, differential accessibility analysis;\n\n\n\nQuantitative ChIP-seq using spike-ins;\n\n\n\nCUT&Tag / CUT&RUN: Novel methods to investigate protein-chromatin interactions;\n\n\n\nFunctional analysis\, including finding nearest genes and custom features\, GO terms and Reactome pathways enrichment;\n\n\n\nBasic multi-omics exploration and integration;\n\n\n\nVisualisations of epigenomics datasets;\n\n\n\nIntroduction to analysis of single cell functional genomics data (scATAC-seq);\n\n\n\nIntroduction to nf-core pipelines for processing and analysis of epi- and functional genomics data : Methylseq\, ChIP-seq\, ATAC-seq.\n\n\n\n\nEntry requirements\n\n\n\nRequired for being able to follow the workshop and complete the computer exercises: \n\n\n\n\nBYOL\, bring your own laptop with R and RStudio installed;\n\n\n\nBasic knowledge in Linux;\n\n\n\nBasic programming experience\, preferably in R.\n\n\n\n\nDesirable: \n\n\n\n\nExperience working on the SNIC center Uppmax or another HPC. We encourage participants to run the linked Uppmax tutorial before the workshop;\n\n\n\nPrevious experience with NGS data analyses;\n\n\n\nCompleting NBIS workshops “Introduction to Bioinformatics using NGS data” and “R Foundations for Life Scientists” or equivalent.\n\n\n\n\nDue to limited space the course can accommodate a maximum of 25 participants. If we receive more applications\, participants will be selected based on selection criteria\, including (but not limited to) correct entry requirements\, motivation to attend the course\, as well as gender and geographical balance. \n\n\n\nLink to application\n\n\n\nhttps://forms.gle/BbmWmLwZFS1ed8EeA URL:https://www.scilifelab.se/event/epigenomics-data-analysis-from-bulk-to-single-cell-online-4/ LOCATION:Online event via Zoom CATEGORIES:Course ORGANIZER;CN="NBIS - National Bioinformatics Infrastructure Sweden":MAILTO:education@nbis.se END:VEVENT END:VCALENDAR