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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221201T120000
DTEND;TZID=Europe/Stockholm:20221201T130000
DTSTAMP:20260403T224355
CREATED:20220912T094220Z
LAST-MODIFIED:20221121T090652Z
UID:10000676-1669896000-1669899600@www.scilifelab.se
SUMMARY:Campus Solna Seminar Series: Pontus Höjer and Guido Baselli
DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an  initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nPontus Höjer\n\n\n\nAfshin Ahmadian – alpha 3 \n\n\n\nOmics exploration with Droplet Barcode Sequencing (DBS). \n\n\n\n\n\nGuido Baselli\n\n\n\nVicent Pelechano – gamma 5 \n\n\n\nIdentification of novel factors regulating non genetic cell plasticity in Chronic Myeloid Leukemia. \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
URL:https://www.scilifelab.se/event/campus-solna-seminar-series-dec-1/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_124630107_HDR-scaled.jpg
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221201T173000
DTEND;TZID=Europe/Stockholm:20221201T180000
DTSTAMP:20260403T224355
CREATED:20220831T154601Z
LAST-MODIFIED:20221110T115015Z
UID:10000665-1669915800-1669917600@www.scilifelab.se
SUMMARY:[Clinical Talks] Recording biology to the genome itself
DESCRIPTION:Jay Shendure\n\n\n\nProfessor of Genome Sciences at the University of Washington \n\n\n\n\n\n\n\nJay Shendure is a Investigator of the Howard Hughes Medical Institute\, Professor of Genome Sciences at the University of Washington\, Director of the Allen Discovery Center for Cell Lineage Tracing\, and Scientific Director of the Brotman Baty Institute for Precision Medicine. \n\n\n\nHis 2005 doctoral thesis with George Church included one of the first successful reductions to practice of next generation DNA sequencing. Dr. Shendure’s research group in Seattle pioneered exome sequencing and its earliest applications to gene discovery for Mendelian disorders and autism; cell-free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays\, saturation genome editing; whole organism lineage tracing\, and massively parallel molecular profiling of single cells.Dr. Shendure is the recipient of the Curt Stern Award from the American Society of Human Genetics (2012)\, the Richard Lounsbery Award from the National Academy of Sciences (2019) and the Mendel Award from the European Society of Human Genetics (2022) and is an elected member of the American Association for the Advancement of Science (AAAS) and the National Academy of Sciences (NAS). He serves or has previously served as an advisor to the NIH Director\, the US Precision Medicine Initiative\, the National Human Genome Research Institute\, the Chan-Zuckerberg Initiative and the Allen Institutes for Cell Science and Immunology. He received his MD and PhD degrees from Harvard Medical School in 2007. \n\n\n\nregister to receive zoom link\n\n\n\nModerator: Michael Akhras\, Colibri Ventures \n\n\n\n\n\n\n\n \n\n\n\nClinical Talks\n\n\n\nClinical Talks is back for more! With a brand new and shiny Season 6. After successfully completing 5 seasons with > 70 enthusiastic Clinical Talkers to our record\, we have barely scratched the surface of all the amazing work our clinical\, academic and industry Life Science community has to offer. More about the upcoming events is available here. \n\n\n\nThese events are co-organized by Karolinska Institutet Innovations AB and SciLifeLab\, and brought to you by Colibri Ventures.
URL:https://www.scilifelab.se/event/clinical-talks-recording-biology-to-the-genome-itself/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/08/Square-500x500-Clinical-Talks@4x.png
ORGANIZER;CN="Clinical Talks":MAILTO:precisionmedicine@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221205T080000
DTEND;TZID=Europe/Stockholm:20221208T170000
DTSTAMP:20260403T224355
CREATED:20221031T164615Z
LAST-MODIFIED:20221031T164743Z
UID:10000724-1670227200-1670518800@www.scilifelab.se
SUMMARY:Workshop on Advanced Correlative Light and Electron Microscopy (CLEM) methods
DESCRIPTION:This 4-day workshop aims to highlight the advanced correlative light and electron microscopy (CLEM) techniques. Participants will learn the latest workflows on how to correlate fluorescence microscopy images with high resolution EM images obtained from state-of-the-art equipment. \n\n\n\nRead more\n\n\n\nWorkshop Content:The workshop includes both theory lectures and practical sessions on In-resin preserved florescence for CLEM\, Tokuyasu ultramicrotome sectioning combined with staining techniques on sections\, Cryo-CLEM and cryo-FIB milling\, as well as opportunities to discuss specific research projects and receive practical advice. Technical challenges and new ideas will be discussed\, and the participants are welcome to contribute with their experiences.  \n\n\n\nTarget Audience:This workshop is supported by the Nordic EMBL partnership for Molecular Medicine and welcomes applications from its members and other institutions. Participants are required to have practical experience in both light and electron microscopy. Due to limited number of places\, registration is based on a selection process. Selected lectures will be open to a larger range of participants and can be registered for under a ‘lecture only’ registration.Certificate/Credits:A course certificate will be provided to successful participants and a recommendation for 1\,5 ECTS.
URL:https://www.scilifelab.se/event/workshop-on-advanced-correlative-light-and-electron-microscopy-clem-methods/
LOCATION:Kemiskt Biologiskt Centrum\, Umeå University\, Linnaeus väg 6\, Umeå\, 90736
CATEGORIES:Course
ORGANIZER;CN="SciLifeLab Ume%C3%A5":MAILTO:umea@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221206T090000
DTEND;TZID=Europe/Stockholm:20221206T184500
DTSTAMP:20260403T224355
CREATED:20220919T142908Z
LAST-MODIFIED:20221124T091417Z
UID:10000683-1670317200-1670352300@www.scilifelab.se
SUMMARY:SciLifeLab Optical Clearing and Expansion symposium
DESCRIPTION:The Advanced Light Microscopy unit at Science for Life laboratory cordially welcomes you to a symposium on developments and applications of clearing and expansion methods from world leading experts. \n\n\n\nRegistration\n\n\n\nRegistration form\n\n\n\n\n\n\n\nProgram\n\n\n\n12:45Whole-body/organ imaging with single-cell resolution by CUBICHiroki Ueda – University Tokyo/Riken BDR\, Japan13:15DISCO clearing approaches paired with spatial molecular mappingHarsharan Bhatia\, Helmholtz Munich\, Germany13:45Volumetric imaging of cleared samplesJacques Paysan – ZEISS14:15Coffee break14:40Expansion Microscopy: Development\, Application\, and Future DirectionsJinyoung Kang – MIT\, USA15:10Pan-ExM-t for molecular ultrastructural visualization of brain tissueOns M’Saad – Yale University\, USA15:40Coffee break16:05Cryo-ExM: coupling cryo-fixation with expansion microscopyVirginie Hamel – University of Geneva\, Switzerland16:35Visualizing cellular and tissue ultrastructure using TRExHugo Damstra – Utrecht University\, The Netherlands17:15-18:45POSTER session with snacks/beverages\n\n\n\n Contact\n\n\n\nhans.blom@scilifelab.se
URL:https://www.scilifelab.se/event/scilifelab-optical-clearing-and-expansion-symposium/
LOCATION:Eva & Georg Klein\, Solnavägen 9\, Stockholm\, 17165\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/09/Ny-Bild-Dec-6.png
ORGANIZER;CN="Advanced Light Microscopy Unit":MAILTO:stewen@kth.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221206T110000
DTEND;TZID=Europe/Stockholm:20221206T120000
DTSTAMP:20260403T224355
CREATED:20221201T122659Z
LAST-MODIFIED:20221201T122702Z
UID:10000743-1670324400-1670328000@www.scilifelab.se
SUMMARY:SciLifeLab Uppsala PhD&Postdoc Online Seminar Series – Cancer Theme
DESCRIPTION:Welcome back to the SciLifeLab Uppsala PhD&Postdoc seminar series! \nThis seminar will take place on Tuesday December 6 from 11h to 11:50h on Zoom (https://uu-se.zoom.us/j/66489618700) \nFor this occasion the speakers will be: \n1. Xiaonan Zhang\, Postdoc at Tobias Sjöblom’s Lab (Cancer Precision Medicine)\, Dept. of Immunology\, Genetics and Pathology\, Uppsala University\n\n\nTitle:  Exploiting allelic loss in cancer therapy: Identification of NAT2 and CYP2D6 as potential targets\n\nSummary:\nLoss of heterozygosity (LOH) is observed in >90% of human cancers and results in the loss of allelic variation in thousands of genes. LOH thus creates genetic differences between tumor and normal cells\, particularly at gene loci where the individual is heterozygous for a wildtype and a loss-of-function (LoF) allele. We have sought to identify genes with common LoF polymorphisms where tumor cells that have lost the gene activity can be targeted by low-molecular-weight drugs or other means. We previously reported that recurring LOH at the NAT2 locus at 8p22 in colorectal cancers (CRCs)\, and the ensuing loss of NAT2 enzyme activity\, could be exploited for anticancer therapy. Recently\, we discovered a group of ATPase inhibitors that exhibited specific toxicity to CRC cells with high NAT2 activity. In parallel\, we investigated the CYP2D6 locus as the CYP2D6 enzyme metabolizes ~25% of clinically used drugs and frequently undergoes LOH in several tumor types. We have established liver cancer cell models and demonstrated that the activity of three anti-cancer compounds\, used in clinic or in clinical trials\, is dependent on CYP2D6. We anticipate that a subset of CRC and liver cancer patients with LOH events in NAT2 or CYP2D6 will benefit from this research. \n\n\n\n2. Kehuan Wang\, PhD Student at Carl-Henrik Heldin’s Lab (Cancer)\, Dept. of Medical Biochemistry and Microbiology\, Uppsala University\n\nTitle: The Proteasomal\, Lysosomal and Autophagosomal Degradation Pathways of PDGFRβ\n\nSummary:\n\nPlatelet-derived growth factor (PDGF)-induced signaling via PDGF receptor β (PDGFRβ) leads to activation of downstream signaling pathways which regulate multiple cellular responses\, such cell migration\, proliferation and survival. Signaling via PDGFRβ is dependent on subcellular location of signaling molecules and hence the internalization of the receptor. It is not clear exactly how PDGFRβ is degraded\, both endosomal/lysosomal and proteasomal degradation has been suggested. In this study\, we have characterized the proteolytic cleavage of ligand-induced PDGFRβ and found that proteolytic cleavage of PDGFRβ resulted in two fragments. This cleavage is dependent on the internalization of PDGFRβ\, which can be blocked by the treatment with bortezomib. Treatment with bortezomib resulted in increased phosphorylation of PDGFRβ and the down-stream signaling molecules PLCγ and STAT3\, while phosphorylation of Erk1/2 MAPK was reduced and Akt was unaffected. We also investigated the possibility that PDGFRβ is degraded by selective autophagy in response to starvation or ligand-induced downregulation of receptor from the cell surface. We found that PDGFRβ accumulated in cells treated with bafilomycin A1 upon serum starvation which could be reversed by inhibition of protein synthesis with cycloheximide. Overexpression of LC3A\, but not LC3B\, promoted the formation of a complex between PDGFRβ and p62. Additionally\, PDGFRβ interacted with LC3A and other members of LC3-like family\, i.e. GABARAP and GABARAPL1. In conclusion\, we speculate that the step-wise proteolytic cleavage of PDGFRβ may have functional consequences for signaling. Macroautophagy may not play a major role in ligand-induced downregulation of PDGFRβ but it could be involved in downregulation of PDGFRβ during starvation via targeting by p62 to non-conventional autophagic or proteasomal pathways that include LC3A and GABARAPs. The functional involvement of these pathways in the control of PDGFRβ levels remains to be further investigated.
URL:https://www.scilifelab.se/event/scilifelab-uppsala-phdpostdoc-online-seminar-series-cancer-theme/
LOCATION:Online event via Zoom
CATEGORIES:Community
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/11/SciLifeLab-PhDPostdoc-conuncil-poster_landscape_December_6.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221206T120000
DTEND;TZID=Europe/Stockholm:20221206T130000
DTSTAMP:20260403T224355
CREATED:20220927T104924Z
LAST-MODIFIED:20221201T154038Z
UID:10000699-1670328000-1670331600@www.scilifelab.se
SUMMARY:Cancelled: OligoNova Hub - National resource for development of oligonucleotide therapies
DESCRIPTION:OligoNova Hub – National resource for development of oligonucleotide therapies\n\n\n\nPär Matsson \n\n\n\nWe will present OligoNova Hub and the capabilities we provide for academic researchers to transform their scientific discoveries into new oligonucleotide therapies. \n\n\n\nSciLifeLab is a national infrastructure within life science with a wide range of advanced technology and expertise. The newly started SciLifeLab site in Gothenburg includes units at both the University of Gothenburg and Chalmers University of Technology and has a strong connection to Sahlgrenska University Hospital. \n\n\n\nA light lunch will be offered during the talks for those joining on site. Online participation via Zoom is also available\, please click the zoom-link below to join the event at the appointed time. \n\n\n\nVenue\n\n\n\nThis event has been cancelled.
URL:https://www.scilifelab.se/event/oligonova-hub-national-resource-for-development-of-oligonucleotide-therapies/
LOCATION:Birgit Thilander Lecture Hall\, Medicinaregatan 3\, Göteborg
CATEGORIES:Event
ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221207T130000
DTEND;TZID=Europe/Stockholm:20221208T130000
DTSTAMP:20260403T224355
CREATED:20221026T084455Z
LAST-MODIFIED:20221109T150910Z
UID:10000722-1670418000-1670504400@www.scilifelab.se
SUMMARY:Data-driven Epidemiology and biology of infections Research Area Symposium
DESCRIPTION:Welcome to a symposia with the new DDLS Fellows and national as well as international researchers within the area of data-driven epidemiology and biology of infections. \n\n\n\nWe encourage personal participation to network with the new DDLS Fellows and other experts of the field however online participation is possible. \n\n\n\nDeadline for registration November 29th \n\n\n\n\n\n\n\nRegister here\n\n\n\nProgram Wednesday\, 7 December\n\n\n\n12:00 LUNCH will be served \n\n\n\n13:00- 13:20 Welcomes and Introductions \n\n\n\nSiv Andersson\, Head of Basic Research at Knut and Alice Wallenberg Foundation\, Uppsala University\,  \n\n\n\nOlli Kallioniemi\, Director SciLifeLab and DDLS Director\, Karolinska Institutet \n\n\n\nMaria Smedh Site Coordinator\, SciLifeLab Göteborg \n\n\n\n13:20 DDLS in Epidemiology and Biology of Infection  \n\n\n\nOliver Billker\, DDLS Research Area Lead\, Umeå University \n\n\n\n13:30 Keynote: Using genomic surveillance data to understand bacterial epidemiology \n\n\n\nNicholas J Croucher\, Imperial College London \n\n\n\n14:10 DDLS Fellow talk: Predicting the disease threats of the future \n\n\n\nJohan Bengtsson-Palme\, DDLS Fellow at Chalmers University of Technology \n\n\n\n14:50 Keynote (virtual) Data and decisions in an imperfect world  \n\n\n\nBill Hanage\, Associate Professor\, Harvard\, School of Public Health  \n\n\n\n15:30 COFFEE \n\n\n\n16:00 DDLS Fellow talk: A global perspective on antimicrobial resistance in animals raised for food \n\n\n\nThomas van Boeckel\, ETH Zurich and future DDLS Fellow at Gothenburg University \n\n\n\n16:40 Pandemic preparedness – The SciLifeLab perspective \n\n\n\nStaffan Svärd\, SciLifeLab Scientific Director\, Uppsala University \n\n\n\n17:10 Discussion and conclusion of the first day \n\n\n\n17:30 Snacks and mingle in Restaurant Nordic \n\n\n\n18:30 SYMPOSIUM DINNER in Restaurant Nordic \n\n\n\n\n\n\n\nProgram Thursday\, 8 December\n\n\n\n8:30 DDLS Fellow Talk: Strength in numbers: leveraging publicly available (meta)genomic data to gain insight into the epidemiology and virulence potential of bacterial pathogens \n\n\n\nLaura Michelle Carroll\, Umeå University \n\n\n\n9:10 Keynote: Data-driven dynamic disease surveillance and studies for mapping systemic effects of the human gut microbiome \n\n\n\nTove Fall\, Uppsala University \n\n\n\n9:50 COFFEE \n\n\n\n10:20 DDLS Fellow Talk: Intimately microbial: symbioses in OB-GYN\,  \n\n\n\nLuisa Warchavchik Hugerth\, DDLS Fellow Uppsala University  \n\n\n\n11:00 National services for data and bioinformatics within DDLS and SciLifeLab \n\n\n\nSara El-Gebali\, SciLifeLab Data Centre\, \n\n\n\nBjörn Nystedt\, National Bioinformatics Infrastructure \n\n\n\nShort presentations followed by a discussion to determine needs for computational support for infections research in Sweden. \n\n\n\n12:00 Discussion: DDLS initiative and Data-Driven Epidemiology and Biology of Infection: where next? \n\n\n\n12:30 LUNCH will be served
URL:https://www.scilifelab.se/event/data-driven-epidemiology-and-biology-of-infections-research-area-symposium/
LOCATION:Europasalen\, Konferenscentrum Wallenberg\, Gothenburg\, Medicinaregatan 20\, Göteborg\, 413 90\, Sweden
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221208T093000
DTEND;TZID=Europe/Stockholm:20221208T123000
DTSTAMP:20260403T224355
CREATED:20221019T101155Z
LAST-MODIFIED:20221206T121942Z
UID:10000716-1670491800-1670502600@www.scilifelab.se
SUMMARY:Science & SciLifeLab Prize Symposium
DESCRIPTION:Welcome to the Scientific Symposium presenting the winners of the 2022 Science & SciLifeLab Prize for Young Scientists.  \n\n\n\nYou can still register to join on Zoom and onsite if seats are available. For onsite registration\, we can not consider special food requirements after November 30. \n\n\n\n\n\n\n\nregistration\n\n\n\n\n\n\n\nScience\, the American Association for the Advancement of Science (AAAS)\, and SciLifeLab joined forces in 2013\, creating the Science & SciLifeLab Prize for Young Scientists to recognize excellence amongst young researchers from around the world. A global Prize aimed at rewarding scientists at an early stage of their careers.  \n\n\n\nThe Prize was launched with the vision of recognizing that global economic health depends on a vibrant research community. A vision that will only come true if we encourage our best and brightest to continue in their chosen fields of research. \n\n\n\nConsidering the difficult economic environment for budding scientists\, it is crucial that we provide them with extra encouragement as they begin their scientific careers. \n\n\n\nThe international Prize is awarded annually to four young scientists for outstanding life science research based on a doctoral degree earned in the previous two years. Each year\, a Grand Prize winner is selected from the applicants to receive 30\,000 USD in prize money\, and the three other category winners are awarded 10\,000 USD each for their accomplishments. The grand prize-winning essay will be published in Science\, and essays from the three category winners will be published online. \n\n\n\nAll four winners of the Science & SciLifeLab Prize for Young Scientists are invited to Sweden December 6-11 to participate in a unique week filled with events in honor of science. They will have the opportunity to meet with leading scientists in their field of research and create life-long connections to support their careers.  \n\n\n\n \n\n\n\nProgram\n\n\n\n\n\n\n\n09:00Breakfast is served outside the Lecture Hall09:30Welcome words:Olli Kallioniemi\, SciLifeLab Director Valda Vinson\, Science AAAS09:45The winners present their research (15’+5′)Moderators: Alexandra Teleki & Mikael Sellin\, SciLifeLab FellowsEndosomes\, Receptors and Viruses: Deciphering the Mechanisms of Infection at the Host-Pathogen Interface  James Daly\, Cell & Molecular Biology Category Prize WinnerUncovering the Degrader of D-type Cyclins Daniele Simoneschi\, Molecular Medicine Category Prize WinnerCoffee break How do bacteria cope with a changing world?  Stefany Moreno-Gámez\, Ecology and Environment Category Prize WinnerThe autobiography of a gut bacterium  Florian Schmidt\, Proteomics and Systems Biology Approaches\, Grand Prize Winner11:35Interview with the WinnersModerators: Alexandra Teleki & Mikael Sellin\, SciLifeLab Fellows11:55Keynote lecture: Rediscover Your Why – Don’t Lose Sight of Why You Pursued Scientific InquiryGilda A. Barabino\, President of the American Association for the Advancement of Science (Bio below)12:25Closing words:Mia Phillipson\, SciLifeLab Co-Director12:30Lunch is served\n\n\n\n\n\n\n\nBooklet\n\n\n\nGilda A. Barabino – Bio\n\n\n\n\n\n\n\n\n\n\n\nPlease contact events@scilifelab.se if you have any questions.
URL:https://www.scilifelab.se/event/science-scilifelab-prize-symposium/
LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/12/Prize_2022_Sida_01.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221212T090000
DTEND;TZID=Europe/Stockholm:20221212T160000
DTSTAMP:20260403T224355
CREATED:20221107T094021Z
LAST-MODIFIED:20221212T094712Z
UID:10000727-1670835600-1670860800@www.scilifelab.se
SUMMARY:SciLifeLab Integrated Structural Biology Platform Symposium
DESCRIPTION:SciLifeLab Integrated Structural Biology invites you to the ISB annual users meeting to be held in Solna on December 12\, 9-16.  \n\n\n\n The program will contain an overview of infrastructures in Sweden that can support your structural biology project\, from gene to final 3D structure. We will also hear examples of projects that were supported by the SciLifeLab infrastructures during 2022\, comprising Cryo-EM\, Structural Proteomics and NMR. \n\n\n\n We welcome you to join in person in the SciLIfeLab building (Tomtebodavägen 23\, 171 65 Solna) but also understand if you prefer to join in by zoom. The meeting will be a hybrid meeting. \n\n\n\nRegistration\n\n\n\n \n\n\n\n \n\n\n\nProgram\n\n\n\nProgram – December 12 \n\n\n\nISB2022_221212Download
URL:https://www.scilifelab.se/event/scilifelab-integrated-structural-biology-platform-symposium/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
ORGANIZER;CN="Integrated Structural Biology Platform at SciLifeLab":MAILTO:cecilia.persson@nmr.gu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221212T100000
DTEND;TZID=Europe/Stockholm:20221212T183000
DTSTAMP:20260403T224355
CREATED:20220927T190428Z
LAST-MODIFIED:20221212T092442Z
UID:10000701-1670839200-1670869800@www.scilifelab.se
SUMMARY:Data-Driven Precision Medicine and Diagnostics Research Area Symposium
DESCRIPTION:Welcome to the first in-person symposium in data-driven precision medicine and diagnostics (PMD) research area. Listen to the Data Driven Life Science (DDLS) fellows recruited in this research area and expand your network with international and national colleagues. \n\n\n\nThe data-driven precision medicine and diagnostics symposium on December 12\, 2022\, is the first in-person symposium in the research area of precision medicine and diagnostics of the DDLS program. This meeting brings together the community in precision medicine and diagnostics and researchers who implemented artificial intelligence and machine learning applications in their research in PMD to improve human health and diagnostics\, introduces newly appointed DDLS fellows in the PMD research area\, and provides opportunities for networking across the research community and the SciLifeLab infrastructures. We are excited to host three international keynote speakers and welcome the community to join us. Hopefully\, this event will inspire you on the potentials of data-driven precision medicine and diagnostics in Sweden. \n\n\n\nTarget group: We welcome all researchers interested in the DDLS program and data-driven precision medicine and diagnostics. \n\n\n\nVenue: Sune Bergström Aula\, BioClinicum\, New Karolinska University Hospital\, Solnavägen 30\, Stockholm  \n\n\n\nOrganizer: SciLifeLab\, host of SciLifeLab & Wallenberg National Program for Data-Driven Life Science. \n\n\n\nDeadline for registration extended to December 12th 9 am (earlier 2nd of December).  \n\n\n\n\n\n\n\nAgenda & speaker bios\n\n\n\nRegister here\n\n\n\n\n\n\n\nAGENDA\n\n\n\nTimeSession/Title of the presentationPresenter10.00Registration10:15Welcome and Introduction to Precision Medicine and Diagnostics Research AreaJanne Lehtiö10:30Scientific presentations – Precision Medicine  Chair: Fulya Taylan  Opening Keynote: FinnGen: a public-private partnership improving human health through genetic researchMervi Aavikko Genomic Medicine Sweden: Lessons learned and future possibilities within the Swedish health data spacePer Sikora Implementation of an academic clinical decision support system for precision oncology: the Molecular Tumor Board Portal (Digital)David Tamborero11:40Lunch 12:45Scientific presentations – Imaging and AI for Precision Medicine  Chair: Magnus Boman  AIDA – supporting AI research in diagnostic imagingClaes Lundström AI-based precision pathology – scalable solutions for cancer patient stratification and phenotypingMattias Rantalainen Deep learning for PET image analysisIda Häggström 13:40Scientific presentations – Digital Twins in Healthcare  Chair: Päivi Östling Building an ecosystem for digital twins in healthcareLiesbet Geris M4-health and digital twins: bring a digital copy of yourself with you throughout your health journeyGunnar Cedersund Towards precision prevention of rheumatoid arthritis; novel tools and novel resultsLars Klareskog14:35Coffee break 15:00SciLifeLab and DDLS Precision Medicine and Diagnostics  Chair: Janne Lehtiö  Introduction to SciLifeLab and DDLS ProgramOlli Kallioniemi SciLifeLab’s Data Center and Precision Medicine & Diagnostics Data Science NodeJohan Rung Bioinformatics support for Precision Medicine and DiagnosticsPär Engström Q&A sessionJanne Lehtiö16:00DDLS Fellows  Chair: Åsa Johansson  Deep lipidomics profiling provides potential biomarkers for precision nutrition approaches in cardiometabolic disease preventionClemens Wittenbecher Integrative multi-omics for precision medicineWen Zhong Harnessing the promise of next-generation plasma profiling for pan-cancer diagnosticsFredrik Edfors 17:00Closing Keynote  Chair: Janne Lehtiö  The need to model OMICs and routine (para)clinical data together – CLL as an example (Digital)Carsten Utoft Niemann17:30 – 18:30Networking with drinks 
URL:https://www.scilifelab.se/event/data-driven-precision-medicine-and-diagnostics-research-area-symposium/
LOCATION:Sune Bergström Aula\, BioClinicum\, New Karolinska University Hospital\, Solnavägen 30\, Stockholm\, 17164\, Sweden
CATEGORIES:Event
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221213T120000
DTEND;TZID=Europe/Stockholm:20221213T130000
DTSTAMP:20260403T224355
CREATED:20220927T105016Z
LAST-MODIFIED:20221212T135834Z
UID:10000700-1670932800-1670936400@www.scilifelab.se
SUMMARY:Cancelled: SciLifeLab Metabolomics platform - Metabolomics for the masses
DESCRIPTION:SciLifeLab Metabolomics platform – Metabolomics for the masses\n\n\n\nOtto Savolainen \n\n\n\nThis event is cancelled \n\n\n\nMetabolites reflect the interaction between the gene cascade and surrounding exposures and are therefore essential components in all living organisms. Metabolites can be used to identify biomarkers of both health conditions and environmental exposures. The SciLifeLab Metabolomics platform offers a range of services for resaerchers interested in metabolomics. \n\n\n\nSciLifeLab is a national infrastructure within life science with a wide range of advanced technology and expertise. The newly started SciLifeLab site in Gothenburg includes units at both the University of Gothenburg and Chalmers University of Technology and has a strong connection to Sahlgrenska University Hospital. \n\n\n\nA light lunch will be offered during the talks for those joining on site. Online participation via Zoom is also available\, please click the zoom-link below to join the event at the appointed time. \n\n\n\nVenue\n\n\n\nAssembly Room Birgit Thilander\, Medicinaregatan 3
URL:https://www.scilifelab.se/event/scilifelab-metabolomics-platform-metabolomics-for-the-masses/
LOCATION:Birgit Thilander Lecture Hall\, Medicinaregatan 3\, Göteborg
CATEGORIES:Event
ORGANIZER;CN="SciLifeLab Gothenburg":MAILTO:gothenburg@scilifelab.se
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221214T090000
DTEND;TZID=Europe/Stockholm:20221214T110000
DTSTAMP:20260403T224355
CREATED:20221128T124459Z
LAST-MODIFIED:20221212T101122Z
UID:10000742-1671008400-1671015600@www.scilifelab.se
SUMMARY:Web-editing Workshop for Unit Website Editors
DESCRIPTION:Current or future editors of unit websites on the SciLifeLab.se website are welcome to join this workshop. \n\n\n\nRegister\n\n\n\nWorkshop will be managed by David Gotthold from the Operations Office. The Workshop will contain: \n\n\n\n\nAccount set-up and permissions\n\n\n\nHow to Log-in\n\n\n\nIntroduction to Word Press\n\n\n\nEditing Basics\n\n\n\nSuggestions for headlines at all unit websites\n\n\n\nOther resources on the SciLifeLab \n\n\n\nThe workshop will end with a 30 minute co-working session where you work individually and can get individual assistance\n\n\n\n\nDavid GottholdProject leaderEvent management\, visits coordination\, webmaster\, communicationsdavid.gotthold@scilifelab.se +46 (0) 72 858 91 03
URL:https://www.scilifelab.se/event/web-editing-workshop-for-unit-website-editors-2/
LOCATION:Online event via Zoom
CATEGORIES:Community
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221214T153000
DTEND;TZID=Europe/Stockholm:20221214T170000
DTSTAMP:20260403T224355
CREATED:20221212T153057Z
LAST-MODIFIED:20221212T153059Z
UID:10000748-1671031800-1671037200@www.scilifelab.se
SUMMARY:Chemical Biology Seminar Series
DESCRIPTION:“TARGETING RIBOSOME BIOGENESIS IN CANCER” \n\n\n\nDimitris KanellisDept. of Medical Biochemistry and Biophysics\, Karolinska Institutet“SYNTHETIC SWITCHES FOR DNA REPAIR – CONTROLLING ENZYMATIC FUNCTIONS AT WILL”Maurice MichelDept. of Oncology-Pathology\, Karolinska Institutet \n\n\n\nDate: Wednesday December 14 \n\n\n\nTime: 3.30 pm \n\n\n\nLocation: Air & Fire\, SciLifeLab \n\n\n\nThe seminars are also available on Zoom. \n\n\n\n\nhttps://ki-se.zoom.us/j/66622023014
URL:https://www.scilifelab.se/event/chemical-biology-seminar-series/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221215T120000
DTEND;TZID=Europe/Stockholm:20221215T130000
DTSTAMP:20260403T224355
CREATED:20220912T095057Z
LAST-MODIFIED:20221129T094808Z
UID:10000679-1671105600-1671109200@www.scilifelab.se
SUMMARY:Campus Solna Seminar Series: Bruno Urien and Kalliroi Sdougkou
DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an  initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nBruno Urien\n\n\n\nBennie Lemmens – alpha 5 \n\n\n\nStudy of Nuclear DNA Replication using Structured Illumination Microscopy. \n\n\n\n\n\nKalliroi Sdougkou\n\n\n\nJonathan Martin – gamma 5 \n\n\n\nSample preparation workflows for enhanced chemical exposomics in human plasma. \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
URL:https://www.scilifelab.se/event/campus-solna-seminar-series-dec-15/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_123412496_HDR2-scaled.jpg
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221215T160000
DTEND;TZID=Europe/Stockholm:20221215T170000
DTSTAMP:20260403T224355
CREATED:20221212T155650Z
LAST-MODIFIED:20221212T155652Z
UID:10000749-1671120000-1671123600@www.scilifelab.se
SUMMARY:Functional analysis of human protein phosphorylation sites
DESCRIPTION:Matthias Selbach  \n\n\n\nPhosphoproteomics routinely quantifies changes in the levels of thousands of phosphorylation sites\, but functional analysis of such data remains a major challenge. I will present three different ways to characterise the function of human phosphorylation sites. First\, I will show how data from in vitro kinase assays can be used to predict kinase activity in phosphoproteomic datasets. Second\, I will show quantitative affinity purification experiments with synthetic phosphopeptides can help to assess their cellular function. Finally\, I will outline how quantitative RNA-interactome capture (qRIC) can quantify the fraction of cellular RNA-binding proteins that are pulled down with polyadenylated mRNAs. Combining qRIC with phosphoproteomics allows us to systematically compare pull-down efficiencies of phosphorylated and non-phosphorylated forms of RBPs. Using qRIC\, we identify over hundred phosphorylation sites with regulatory potential\, including known regulatory sites. Follow-up experiments on the cardiac splicing regulator RBM20 revealed that multiple phosphorylation sites in the C-terminal disordered region affect nucleo-cytoplasmic localisation\, association with cytosolic RNA granules and alternative splicing.      \n\n\n\nSelected publications\n\n\n\n\nVieira-Vieira\, CH\, Dauksaite\, V.\, Sporbert\, A.\, Gotthardt\, M. and Selbach M. (2022) Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20. Mol Cell 82\, 2069-2083.\n\n\n\nMeyer\, K.\, Kirchner\, M.\, Uyar\, B.\, Cheng\, J.Y.\, Russo\, G.\, …\, and Selbach\, M. (2018). Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs. Cell 175\, 239-253.\n\n\n\nImami\, K.\, Milek\, M.\, Bogdanow\, B.\, Yasuda\, T.\, Kastelic\, N.\, …\, and Selbach\, M. (2018). Mol Cell. Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis. Mol Cell 72\,\n\n\n\nZauber\, H.\, Kirchner\, M.\, and Selbach\, M. (2018). Picky: a simple online PRM and SRM method designer for targeted proteomics. Nat Methods 15\, 156-157.\n\n\n\nMcShane\, E.\, Sin\, C.\, Zauber\, H\, Wells JN\, Donnelly N\, …\, and Selbach M. (2016). Kinetic analysis of protein stability reveals age-dependent degradation. Cell 167\, 803-815.\n\n\n\nSchwanhausser\, B.\, Busse\, D.\, Li\, N.\, Dittmar\, G.\, Schuchhardt\, J.\, Wolf\, J.\, Chen\, W.\, and Selbach\, M. (2011). Global quantification of mammalian gene expression control. Nature 473\, 337-342.
URL:https://www.scilifelab.se/event/functional-analysis-of-human-protein-phosphorylation-sites/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
ORGANIZER;CN="Janne Lehti%C3%B6":MAILTO:janne.lehtio@scilifelab.se
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221216T090000
DTEND;TZID=Europe/Stockholm:20221216T093000
DTSTAMP:20260403T224355
CREATED:20220923T091314Z
LAST-MODIFIED:20221201T124338Z
UID:10000688-1671181200-1671183000@www.scilifelab.se
SUMMARY:[Clinical Talks] Functional precision medicine using AI drug discovery
DESCRIPTION:Greg Vladimer\n\n\n\nVice President\, Translational Research at Exscientia \n\n\n\n\n\n\n\nGreg Vladimer\, VP\, Translational Research joined Exscientia through the acquisition of Allcyte\, a pioneer in the field of AI-first functional precision oncology and translational cancer research\, where he was a Scientific Co-Founder and the Chief Scientific Officer. At Allcyte\, he and his team pushed the boundaries of translational cancer research through the use of disease relevant primary human cancer samples\, high content imaging\, custom AI-powered computer vision\, and scalable cloud computing. Greg has a PhD from University of Massachusetts Medical School in Immunology\, after which he moved to Vienna as an EMBO-supported Postdoctoral Fellow at CeMM where he and a colleague invented the first-generation platform used for the translational work\, and spearheaded the first ever prospective interventional clinical trial showing that drugs prioritised using a functional precision medicine tool had clinical benefit for late stage blood cancer patients. \n\n\n\nregister to receive zoom link\n\n\n\nModerator: Päivi Östling\, SciLifeLab \n\n\n\n\n\n\n\n \n\n\n\nClinical Talks\n\n\n\nClinical Talks is back for more! With a brand new and shiny Season 6. After successfully completing 5 seasons with > 70 enthusiastic Clinical Talkers to our record\, we have barely scratched the surface of all the amazing work our clinical\, academic and industry Life Science community has to offer. More about the upcoming events is available here. \n\n\n\nThese events are co-organized by Karolinska Institutet Innovations AB and SciLifeLab\, and brought to you by Colibri Ventures.
URL:https://www.scilifelab.se/event/functional-precision-medicine-using-ai-drug-discovery/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/08/Square-500x500-Clinical-Talks@4x.png
ORGANIZER;CN="Clinical Talks":MAILTO:precisionmedicine@scilifelab.se
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