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X-WR-CALDESC:Events for SciLifeLab
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240112T110000
DTEND;TZID=Europe/Stockholm:20240112T120000
DTSTAMP:20260403T222657
CREATED:20231206T165224Z
LAST-MODIFIED:20231207T151005Z
UID:10001062-1705057200-1705060800@www.scilifelab.se
SUMMARY:Calls for new project support in chemical biology and drug discovery
DESCRIPTION:The chemical biology unit (CBCS) and the Drug discovery and development (DDD) platform at SciLifeLab have calls out for projects – see https://anubis.scilifelab.se \n\n\n\nCBCS is looking for projects in Chemical Biology which includes assay development for small molecule screening and profiling\, as well as enabling chemistry. For more information\, please visit www.cbcs.se. \n\n\n\nThe DDD platform has a call looking for new project proposals for drug discovery. All therapeutic modalities that can be developed in collaboration with the DDD platform at SciLifeLab are of interest\, including small molecules\, antibodies\, oligonucleotides and new modalities. \n\n\n\nSome users and projects are at the intersection between chemical biology and drug discovery. We believe this webinar will help you to find out were your project fits in best. \n\n\n\nsign up here\n\n\n\nProgram: \n\n\n\n1. Presentation of CBCS offerings2. Presentation of the DDDp offerings3. Q&A \n\n\n\nOrganizer: the Chemical Biology Consortium Sweden and the Drug Discovery & Development platform
URL:https://www.scilifelab.se/event/calls-for-new-project-support-in-chemical-biology-and-drug-discovery-2/
LOCATION:Online event via Zoom
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240112T130000
DTEND;TZID=Europe/Stockholm:20240112T140000
DTSTAMP:20260403T222657
CREATED:20231220T101638Z
LAST-MODIFIED:20240112T114300Z
UID:10001072-1705064400-1705068000@www.scilifelab.se
SUMMARY:DDLS Data Science Node information
DESCRIPTION:Welcome to a brief update on the status of the Data Science Node (DSN) for Cell and Molecular Biology (CMB) and information about a community survey that will open after this meeting. Data Science Node management\, Sverker Holmgren and Thomas Svensson will describe the survey and answer questions. The event is open to everyone. Please register to get the Zoom link in your mailbox.  You can pre-send input or questions regarding the DSN in CMB to Sverker and Thomas in the registration form. \n\n\n\n\n\n\n\n\n \n\n\n\nRegistration\n\n\n\n\n\nSurvey\n\n\n\nLink to Survey\n\n\n\n\nRead more about DDLS Data Science Nodes
URL:https://www.scilifelab.se/event/ddls-data-science-node-information/
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/03/CMB_web.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240115T150000
DTEND;TZID=Europe/Stockholm:20240115T160000
DTSTAMP:20260403T222657
CREATED:20231227T115931Z
LAST-MODIFIED:20231227T120134Z
UID:10001077-1705330800-1705334400@www.scilifelab.se
SUMMARY:Genomics\, Imaging and AI - three technologies which are changing biological research and clinical practice
DESCRIPTION:Prof. Ewan Birney is Deputy Director General of EMBL and Joint Director of EMBL-EBI. Prof. Birney will come to Stockholm to give a talk on Jan 15 from 15:00 to 16:00 at Biomedicum\, KI Campus Solna. Come and listen to an exciting talk about the next steps in medical research! \n\n\n\nJan 15 at 15:00 – 16:00 \n\n\n\nEva & Georg Klein Conference hall\, Biomedicum\, Solnavägen 9 \n\n\n\nWelcome! \n\n\n\nProf. Ewan Birney flyer Jan 15Download flyer
URL:https://www.scilifelab.se/event/genomics-imaging-and-ai-three-technologies-which-are-changing-biological-research-and-clinical-practice/
LOCATION:Eva & Georg Klein lecture hall\, Biomedicum\, Karolinska Institutet\, Solnavägen 9\, Solna\, Solnavägen 9\, Solna
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/SciLifeLab_EMBL-e1678190893272.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240118T090000
DTEND;TZID=Europe/Stockholm:20240118T150000
DTSTAMP:20260403T222657
CREATED:20231208T120428Z
LAST-MODIFIED:20231208T120459Z
UID:10001064-1705568400-1705590000@www.scilifelab.se
SUMMARY:Opening of the Lightsheet 7 at the Centre for Cellular Imaging
DESCRIPTION:The Centre for Cellular Imaging is pleased to announce the purchase and installation of the Lightsheet 7 fluorescence microscopemicroscope. \n\n\n\nLight sheet fluorescence microscopy (LSFM) uses a thin sheet of light to excite only fluorophores within the focal volume. It is ideal for fast and gentle imaging of whole living model organisms\, tissues\, and cells as they develop – over extended periods of time. Furthermore\, the Lightsheet 7 is designed to handle large optically cleared specimens with subcellular resolution. Dedicated optics\, sample chambers\, and holders allow adaption to the refractive index of the chosen clearing method. \n\n\n\nThe Lightsheet 7 is now installed at the Centre for Cellular Imaging and to celebrate this we will host an “Opening Day” with seminars and demos\, where you can learn about this technology and other types of equipment available at the CCI.Please join us on January 18th to explore what is possible with this new instrumentation! \n\n\n\nRegistration deadline: January 11th \n\n\n\nregistration
URL:https://www.scilifelab.se/event/opening-of-the-lightsheet-7-at-the-centre-for-cellular-imaging/
LOCATION:Birgit Thilander Lecture Hall\, Medicinaregatan 3\, Göteborg
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/12/banner-ls7.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240118T120000
DTEND;TZID=Europe/Stockholm:20240118T130000
DTSTAMP:20260403T222657
CREATED:20230711T120215Z
LAST-MODIFIED:20240108T102321Z
UID:10000938-1705579200-1705582800@www.scilifelab.se
SUMMARY:Campus Solna Seminar Series: Samu Himanen & Donal Barrett
DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an  initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nSamu Himanen\n\n\n\nAnniina Vihervaara – alpha 3 \n\n\n\nTracking Pol II modifications and nascent trascription by Pol I-III complexes at single-nucleotide resolution \n\n\n\n\n\nDonal Barrett\n\n\n\nVicent Pelechano – gamma 5 \n\n\n\nRapid electronic quantification of clinical pathogens using novel DNA nanoballs \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
URL:https://www.scilifelab.se/event/campus-solna-seminar-series-dec-7/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_123412496_HDR2-scaled.jpg
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240119T100000
DTEND;TZID=Europe/Stockholm:20240119T110000
DTSTAMP:20260403T222657
CREATED:20240115T114456Z
LAST-MODIFIED:20240116T094413Z
UID:10001107-1705658400-1705662000@www.scilifelab.se
SUMMARY:AICell Lab -- Building AI Systems for Human Cell Modeling and Simulation
DESCRIPTION:NBIS\, Scilifelab’s Bioinformatics platform\, arranges an open AI and IO Seminar Series aimed at knowledge-sharing about Artificial Intelligence and Integrative Omics (AI & IO) analysis and applications in the Life Science community. The seminar series is open to everyone. The seminar is run over Zoom on the third Friday of the month during academic terms\, typically between 10 and 11 am\, with ca. 45 min long presentation and 15 min discussion. \n\n\n\nFor further info\, please see this website. \n\n\n\n \n\n\n\n\n\n\n\nAICell Lab — Building AI Systems for Human Cell Modeling and Simulation\n\n\n\nWei Ouyang\, DDLS fellow\, Royal Institute of Technology\, KTH \n\n\n\nThe AICell Lab is a newly founded group by the Data-Driven Life Science fellows program at the department of applied physics at KTH. The lab is dedicated to building artificial intelligence (AI) systems for cell and molecular biology\, with the ultimate goal of modeling the human cell and building human cell simulators using powerful AI models. The lab’s approach to this grand challenge involves not only innovations in data analysis and modeling\, but also in data generation\, specifically the creation of an automated imaging farm equipped with multiple microscopes\, robotic arms\, liquid handling robots\, and automatic incubators. The lab’s AI software infrastructure enables real-time augmentation of microscopy views\, generating artificial labels and annotations\, and optimizing experimental conditions to capture rare events in live cells. The long-term goal of the AICell Lab is to create large-scale whole human cell models trained on existing multi-omics datasets and new data generated by the imaging farm\, which have the potential to revolutionize in-silico cell experimentation and drug discovery while contributing to a holistic and systematic understanding of the human cell. \n\n\n\nClick here to join zoom conference
URL:https://www.scilifelab.se/event/ai-approach-to-cell-and-molecular-biology/
LOCATION:Online event via Zoom
CATEGORIES:Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240119T130000
DTEND;TZID=Europe/Stockholm:20240119T140000
DTSTAMP:20260403T222657
CREATED:20240110T132404Z
LAST-MODIFIED:20240110T132648Z
UID:10001102-1705669200-1705672800@www.scilifelab.se
SUMMARY:Webinar: SiMSen-seq\, new tool for ultrasensitive detection of circulating tumor DNA in childhood malignancies
DESCRIPTION:Next up on the Clinical Genomics Webinar Series: \n\n\n\nClinical Genomics Gothenburg has organised an exciting new webinar to be held on Friday 19th January 2024 at 13:00 on Zoom (click here to join). \n\n\n\nIn the seminar: “SiMSen-seq: A new tool for ultrasensitive detection of circulating tumor DNA in childhood malignancies”\, focuses on ultrasensitive sequencing\, Martin Dalin\, sheds light on a clinical application of SiMSen-seq. \n\n\n\nIf you have questions\, please contact the host Marcela Davila (marcela.davila@gu.se) or CG vicePCO Esther González-Padilla (esther.gonzalez-padilla@scilifelab.se). \n\n\n\nEveryone is welcome so feel free to spread the details with anyone who might be interested. \n\n\n\nMartin Dalin is a professor at Sahlgrenska Center for Cancer Research\, Wallenberg Centre for Molecular and Translational Medicine\, the Institute of Clinical Sciences\, Sahlgrenska Academy at University of Gothenburg
URL:https://www.scilifelab.se/event/webinar-simsen-seq-new-tool-for-ultrasensitive-detection-of-circulating-tumor-dna-in-childhood-malignancies/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/01/SiMSen-sec_webinar.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240122T151500
DTEND;TZID=Europe/Stockholm:20240122T161500
DTSTAMP:20260403T222657
CREATED:20231211T083458Z
LAST-MODIFIED:20240110T165531Z
UID:10001067-1705936500-1705940100@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Nucleosomes for all: histone-based chromatin in noneukaryotic organisms
DESCRIPTION:Karolin Luger \n\n\n\nProfessor University of Colorado\, USA \n\n\n\nPLEASE NOTE: This seminar will be given both in Uppsala\, BMC at January 22:nd and additionally in Solna at January 23\, 14:00\, George and Eva Klein\, Biomedicum\, Solnavägen 9\, Stockholm \n\n\n\n\n\n\n\nBio\n\n\n\nKarolin Luger is a distinguished professor and the Jennie Smoly Caruthers Endowed Chair of Biochemistry at the University of Colorado in Boulder\, and an investigator for the Howard Hughes Medical Institute. She is recognized for her work on nucleosome structure and interacting proteins. The lab also studies the DNA damage recognition protein PARP1 and its interactions with chromatin\, with the aim of developing novel PARP inhibitors for cancer therapy. The group explores histone-based DNA organization in non-eukaryotic organisms\, to gain insight into the evolutionary origin of the nucleosome. \n\n\n\nLuger was born in Austria and obtained a degree in Biochemistry from the University of Innsbruck. She obtained her Ph.D. in biophysics from the Biocenter Basel\, then moved to a postdoc at the ETH Zuerich in 1990. She started her independent career at Colorado State University in 1999\, and in 2015 moved to the University of Colorado at Boulder. She is a fellow of the Biophysical Society\, a member of the National Academy of Science; the American Academy of Arts and Science; and EMBO. In 2023\, she was awarded the World Laureate Association (WLA) Prize in Life Science or Medicine for her groundbreaking work on nucleosome structure. \n\n\n\n \n\n\n\nNucleosomes for all: histone-based chromatin in noneukaryotic organisms\n\n\n\nAll eukaryotes organize their DNA into nucleosomes\, consisting of an octamer of the four core histone proteins H2A\, H2B\, H3\, and H4\, around which 147 base pairs of DNA are wrapped in two tight superhelical turns. Histones were an early acquisition in eukaryogenesis that allowed for massive genome expansion\, a prerequisite for the complexity observed in modern-day eukaryotes. Histones are the targets of epigenetic modifications through the incorporation of histone variants and histone post-translational modifications\, and require elaborate assembly and remodeling machinery for gene regulation. Who provided the chromatin starter kit to the early eukaryote? Many archaea organize their genomes with single\, non-diversified histones that form slinky-like structures\, without the requirement for additional machinery to assemble and disassemble nucleosomal structures.  A subclass of giant viruses (ancient double-stranded DNA viruses that infect amoebae) also encode their own histones\, and these form meta-stable nucleosome-like structures with distinct features. Unexpectedly\, we recently discovered that histones are sporadically present in the bacterial domain of life. In a stunning reversal of ‘histone logic’\, these small histones encase straight DNA rather than wrapping it around them.  As such\, histones are no longer a prerogative of eukaryotes but appear to be an ancient DNA packaging principle that has adapted to varying constraints in different domains of life. \n\n\n\n \n\n\n\n\n\n\n\nHost: Sebastian Deindl sebastian.deindl@icm.uu.se UU\, Simon Elsässer simon.elsasser@scilifelab.se\, KI
URL:https://www.scilifelab.se/event/the-svedberg-seminar-karolin-luger/
LOCATION:BMC Trippelrummet\, Husargatan 3\, entrance C11\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240123T140000
DTEND;TZID=Europe/Stockholm:20240123T150000
DTSTAMP:20260403T222657
CREATED:20240116T142015Z
LAST-MODIFIED:20240122T170453Z
UID:10001111-1706018400-1706022000@www.scilifelab.se
SUMMARY:Spotlight seminar - Nucleosomes for all: histone-based chromatin in noneukaryotic organisms
DESCRIPTION:Karolin Luger\n\n\n\nUniversity of Colorado\, USA \n\n\n\n\n\n\n\nPLEASE NOTE: This seminar will be given both in Uppsala\, BMC Trippelrummet at January 22 15.15-16.15 and additionally in Solna at January 23\, 14:00\, George and Eva Klein\, Biomedicum\, Solnavägen 9\, Stockholm \n\n\n\nBio\n\n\n\nKarolin Luger is a distinguished professor and the Jennie Smoly Caruthers Endowed Chair of Biochemistry at the University of Colorado in Boulder\, and an investigator for the Howard Hughes Medical Institute. She is recognized for her work on nucleosome structure and interacting proteins. The lab also studies the DNA damage recognition protein PARP1 and its interactions with chromatin\, with the aim of developing novel PARP inhibitors for cancer therapy. The group explores histone-based DNA organization in non-eukaryotic organisms\, to gain insight into the evolutionary origin of the nucleosome. \n\n\n\nLuger was born in Austria and obtained a degree in Biochemistry from the University of Innsbruck. She obtained her Ph.D. in biophysics from the Biocenter Basel\, then moved to a postdoc at the ETH Zuerich in 1990. She started her independent career at Colorado State University in 1999\, and in 2015 moved to the University of Colorado at Boulder. She is a fellow of the Biophysical Society\, a member of the National Academy of Science; the American Academy of Arts and Science; and EMBO. In 2023\, she was awarded the World Laureate Association (WLA) Prize in Life Science or Medicine for her groundbreaking work on nucleosome structure. \n\n\n\nNucleosomes for all: histone-based chromatin in noneukaryotic organisms\n\n\n\nAll eukaryotes organize their DNA into nucleosomes\, consisting of an octamer of the four core histone proteins H2A\, H2B\, H3\, and H4\, around which 147 base pairs of DNA are wrapped in two tight superhelical turns. Histones were an early acquisition in eukaryogenesis that allowed for massive genome expansion\, a prerequisite for the complexity observed in modern-day eukaryotes. Histones are the targets of epigenetic modifications through the incorporation of histone variants and histone post-translational modifications\, and require elaborate assembly and remodeling machinery for gene regulation. Who provided the chromatin starter kit to the early eukaryote? Many archaea organize their genomes with single\, non-diversified histones that form slinky-like structures\, without the requirement for additional machinery to assemble and disassemble nucleosomal structures.  A subclass of giant viruses (ancient double-stranded DNA viruses that infect amoebae) also encode their own histones\, and these form meta-stable nucleosome-like structures with distinct features. Unexpectedly\, we recently discovered that histones are sporadically present in the bacterial domain of life. In a stunning reversal of ‘histone logic’\, these small histones encase straight DNA rather than wrapping it around them.  As such\, histones are no longer a prerogative of eukaryotes but appear to be an ancient DNA packaging principle that has adapted to varying constraints in different domains of life. \n\n\n\nHost: Simon Elsässer simon.elsasser@scilifelab.se\, KI and Sebastian Deindl sebastian.deindl@icm.uu.se UU
URL:https://www.scilifelab.se/event/spotlight-seminar-nucleosomes-for-all-histone-based-chromatin-in-noneukaryotic-organisms/
LOCATION:Eva & Georg Klein lecture hall\, Biomedicum\, Karolinska Institutet\, Solnavägen 9\, Solna\, Solnavägen 9\, Solna
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240125T120000
DTEND;TZID=Europe/Stockholm:20240125T130000
DTSTAMP:20260403T222657
CREATED:20240102T093939Z
LAST-MODIFIED:20240111T085934Z
UID:10001078-1706184000-1706187600@www.scilifelab.se
SUMMARY:Campus Solna Seminar Series: João Varela & Björn Hammarström
DESCRIPTION:Welcome to join the Campus Solna Seminar Series – an  initiative to promote the fantastic science ongoing at Campus Solna and hopefully forge more internal communication and collaboration between within Campus Solna. The format consists of two 15 min talks (One speaker from the Alpha-building and one from the Gamma-building respectively)\, with an additional 5 min of questions. Presentation of ongoing (unpublished) projects is strongly encouraged. \n\n\n\nThe seminars are held Thursdays 12:00-13:00. You can bring your lunch to the seminar. \n\n\n\nThis week:\n\n\n\n\n\n\nJoão Varela\n\n\n\nAman Russon – alpha 4 \n\n\n\nFiber-based approach to Cancer Cell-picking for Diagnostric Applications \n\n\n\n\n\nBjörn Hammarström\n\n\n\nMartin Viklund – gamma 3 \n\n\n\n \n\n\n\n\n\n\nThis seminar series is organized by the PhD & Postdoc Council. For more information about the Council and other events check our page.
URL:https://www.scilifelab.se/event/campus-solna-seminar-series-joao-varela-bjorn-hammarstrom/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/IMG_20221103_120135408_HDR-scaled.jpg
ORGANIZER;CN="SciLifeLab Solna PhD & Postdoc Council":MAILTO:phd-council@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240125T120000
DTEND;TZID=Europe/Stockholm:20240125T133000
DTSTAMP:20260403T222657
CREATED:20231221T131449Z
LAST-MODIFIED:20240125T112047Z
UID:10001076-1706184000-1706189400@www.scilifelab.se
SUMMARY:Drug discovery & development possibilities for industry at SciLifeLab NMR unit and MAX IV BioMAX beamline
DESCRIPTION:Welcome to this webinar directed to life science companies and researchers in drug discovery and development. Learn about support available from Swedish research infrastructures. Gain insights from companies that have used the NMR units at SciLifeLab and the BioMAX beamline at MAX IV Laboratory  for their drug discovery and development projects. \n\n\n\nBreak out rooms for specific questions on each technique will be arranged in the end. \n\n\n\nIn collaboration with InfraLife partners SwedenBIO and The Swedish Association of the Pharmaceutical Industry\, LIF. \n\n\n\nTopics and Speakers\n\n\n\nThe BioMAX beamline in drug discoveryAna Gonzales\, MAX IV \n\n\n\nLeveraging X-ray crystallographic data through advanced infrastructuresBjörn Walse CEO\, SARomics Biostructures \n\n\n\nSciLifeLab NMR in drug discovery & developmentCecilia Persson\, ISB Platform coordinator\, SciLifeLab NMR Centre \n\n\n\nQuality testing of biosimilars using NMRCarl Diehl\, Manager of NMR Services\, SARomics Biostructures \n\n\n\nBreak out rooms for further questions and discussionNMR-break out room with Cecilia P and Carl DBioMAX-break out room with Ana G and Björn W \n\n\n\n \n\n\n\nUseful Links\n\n\n\n\nIndustry case: The Swedish NMR-Centre\, part of SciLifeLab – a Crucial Asset for SARomics Biostructures’ Drug Discovery ServicesR Centre\n\n\n\nSwedish NMR Centre\n\n\n\nBiomax at MAX IV Laboratory\n\n\n\nInfraLife\n\n\n\n\n\n\n\n\nregistration
URL:https://www.scilifelab.se/event/drug-discovery-development-possibilities-for-industry-at-scilifelab-and-max-iv/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2021/05/Infralife-square.jpg
ORGANIZER;CN="InfraLife":MAILTO:events@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240126T080000
DTEND;TZID=Europe/Stockholm:20240126T190000
DTSTAMP:20260403T222657
CREATED:20231129T153110Z
LAST-MODIFIED:20240117T102834Z
UID:10001051-1706256000-1706295600@www.scilifelab.se
SUMMARY:Complex Diseases Conference
DESCRIPTION:Precision health around the corner – deciphering complex diseases \n\n\n\nIt is our pleasure to announce the second conference for Genomic Medicine Sweden (GMS) – Complex Diseases. The event aims at bringing together researchers and clinicians to accelerate the clinical implementation of precision medicine of complex diseases. The meeting is open to everyone with professional interest in the field. \n\n\n\nRead more\n\n\n\nRegistration\n\n\n\nProgram\n\n\n\nGMS-Complex-diseases-conference-1Download\n\n\n\n \n\n\n\nDate: January 26th\, 2024Time: 9 am – 7 pmWhere: Wenner-Gren Center\, Stockholm
URL:https://www.scilifelab.se/event/complex-diseases-conference/
LOCATION:Wenner-Gren Center\, Sveavägen 166\, Stockholm\, 113 46\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/11/GMS.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240126T150000
DTEND;TZID=Europe/Stockholm:20240126T160000
DTSTAMP:20260403T222657
CREATED:20240112T110052Z
LAST-MODIFIED:20240112T110206Z
UID:10001105-1706281200-1706284800@www.scilifelab.se
SUMMARY:From human population variation to ligand binding sites via SARS-CoV-2
DESCRIPTION:Talk by\n\n\n\nGeoff Barton\, Professor of Bioinformatics and Head of Division of Computational Biology School of Life Sciences University of Dundee\, Dundee\, Scotland\, UK. \n\n\n\nTitle\n\n\n\nFrom human population variation to ligand binding sites via SARS-CoV-2 \n\n\n\nAbstract\n\n\n\nIn this talk I will present an analysis that compares publicly available variation data for human with variation seen across all available protein sequences regardless of species.  The analysis confirms patterns of variation in human are consistent with protein structural features (e.g. a-helix and b-strand) but highlights structurally and functionally important sites in around 15\,000 human protein domains that are not found by conventional sequence analysis methods. The identified sites are enriched in disease-associated variants\, ligand binding residues and protein-protein interaction sites. \n\n\n\nI will explain the method and illustrate the new analysis with examples including the Nuclear Receptor Ligand Binding Domains and G-protein coupled receptors (GPCRs) which are important therapeutic targets. \n\n\n\nThe study makes heavy use of the popular Jalview (www.jalview.org) sequence analysis program developed since 1996 in my group\, so I will also give a brief update on Jalview’s new features for exploring nsSNPs on alignments and three-dimensional structures.  \n\n\n\nA preprint describing some aspects of this work was deposited on bioRxiv MacGowan et al\, 2017: https://doi.org/10.1101/127050) and a specific application to the Ankyrin Repeats was published: Utgés et al\, 2021 https://doi.org/10.1371/journal.pcbi.1009335  More recent work applies the methods to ligand binding sites: Utgés et al\, 2023:  https://www.researchsquare.com/article/rs-3185838/v1 \n\n\n\nI will also give a brief summary of our work on SARS-CoV-2 that builds on our experience of analysing human population data MacGowan et al\, 2020: https://doi.org/10.1101/2020.05.03.074781\,MacGowan et al\, 2022:  https://doi.org/10.1371/journal.pcbi.1009922\, Barton\, M. I. et al\, 2021: https://doi.org/10.1101/2021.05.18.444646 \n\n\n\nRead more
URL:https://www.scilifelab.se/event/from-human-population-variation-to-ligand-binding-sites-via-sars-cov-2/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
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DTSTART;TZID=Europe/Stockholm:20240129T151500
DTEND;TZID=Europe/Stockholm:20240129T161500
DTSTAMP:20260403T222657
CREATED:20240109T110554Z
LAST-MODIFIED:20240109T135707Z
UID:10001101-1706541300-1706544900@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - The Impossibility of Whales: somatic evolution across the tree of life
DESCRIPTION:Alex Cagan \n\n\n\nAssistant ProfessorUniversity of Cambridge\, UK \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nAlex Cagan is an Assistant Professor at the Departments of Genetics\, Pathology and Veterinary Medicine at the University of Cambridge and affiliate of the Programme for Cancer\, Ageing and Somatic Mutation at the Wellcome Sanger Institute. He obtained his PhD in comparative genomics with Svante Pääbo at the Max Planck Institute for Evolutionary Anthropology before doing a post-doc with Inigo Martincorena at the Wellcome Sanger Institute to develop methods to study somatic evolution. His work focuses on the development and application of methods to study somatic evolutionary processes across species to gain insights into cancer\, ageing and environmental monitoring. Alex is also enthusiastic about science illustration and communication. \n\n\n\n \n\n\n\nThe Impossibility of Whales: somatic evolution across the tree of life\n\n\n\nSomatic mutations accumulate in cells throughout life. They underpin the development of cancer and may contribute to ageing. Studying these mutations in healthy tissues has been challenging due to the difficulty of detecting mutations present in single cells or small clones in a tissue. Recent technical advances are enabling their study\, revealing how cells accumulate mutations at different rates and how clonal expansions of mutant cells colonise tissues. Yet little is known about how these processes operate in non-human species. We performed whole-genome sequencing of 208 intestinal crypts from 56 individuals to study the landscape of somatic mutation across 16 mammalian species. This comparative analysis of somatic mutagenesis shed light on the diversity of mutagenic processes across species\, and on long-standing questions regarding the evolution of somatic mutation rates and their role in cancer and ageing. We are now developing methods to enable the study of somatic evolution across any cell type in any species. These approaches aim to provide insights into the evolutionary origin of somatic mutational processes and the mechanisms that underlie cancer resistance in species where cancer is rare.   \n\n\n\n \n\n\n\n\n\n\n\nHost: Matthew Webster matthew.webster@imbim.uu.se\, UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-alex-cagan/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
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