SciLifeLab The Svedberg seminar series 2013-11-11
Department of Evolutionary Biology, Science for Life Laboratory, Uppsala University, Sweden
Mattias Jakobsson has a broad interest in population genetics and human evolution. His lab uses computational approaches to decipher the complex patterns of large-scale human genomic variation, and to understand their implications for human demographic and evolutionary history.
“The genomic footprint of early northern Europeans”
Extracting genetic information from ancient human remains is now beginning to show its full potential. We have generated genomic data, up to 1X coverage, from several Scandinavia Stone-Age human remains that illuminate the impact of the agricultural revolution on patterns of genomic variation in Europe. Stone-Age Scandinavian individuals show remarkable population structure corresponding to their cultural association and the farmers are genetically most similar to extant southern Europeans, contrasting sharply to the hunter-gatherers whose genetic signature is similar to extant northern Europeans. Looking beyond Scandinavia, we show that the Tyrolean Iceman from an agricultural context is most similar to Stone-Age Scandinavian farmers, whereas the 7,000 years old Iberian hunter-gatherers are most similar to Stone-Age Scandinavian hunter-gatherers, opposite to what would have been predicted from their geographical origins. This finding shows that lifestyle may be the major determinant of genetic similarity in pre-historic Europe rather than geography as in modern-day Europe.
Host: Ulf Landegren