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SciLifeLab The Svedberg seminar series, Juleen Zierath, The role of Diet and Exercise in Type 2 Diabetes

Monday October 7, 2019

Prof. Juleen Zierath

Dept. of Molecular Medicine and Surgery and the Dept. of Physiology and Pharmacology at Karolinska lnstitutet

Juleen R. Zierath is presently Professor of Clinical lntegrative Physiology and Head of the Section of lntegrative Physiology at the Dept. of Molecular Medicine and Surgery and the Dept. of Physiology and Pharmacology at Karolinska lnstitutet.

She is also appointed Professor at University of Copenhagen, where she is Executive Director at the Novo Nordisk Foundation Center for Basic Metabolic Research.

Professor Zierath was President of the European Association for the Study of Diabetes and the European Foundation for the Study of Diabetes between 2015-2018.She is a member of the Royal Swedish Academy of Sciences and the Nobel Assembly.
She was Chair of the Nobel Committee at Karolinska lnstitutet between 2013 and 2015 and is currently a member of this Committee.

Title of the talk: The Role of Diet and Exercise in Modifying the Epigenetic Landscape in Type 2 Diabetes

Type 2 diabetes shares many features of “accelerated aging” including insulin resistance, defective oxidative metabolism/mitochondrial function and loss of muscle mass. Strikingly, long-term participation in vigorous exercise programs mitigates secondary aging, reduces disability and mortality, and reduces type 2 diabetes risk. This association advances the notion that exercise promotes “healthy aging” and improves the quantity and quality of life. At the molecular level, exercise results in a rapid, but transient change in the epigenome by modifying DNA methylation of the promoters of key genes regulating mitochondrial function and biogenesis in skeletal muscle. Recent evidence suggests that intimate links between epigenetic regulation and the circadian clock exist that are likely to contribute to the plasticity of insulin sensitive organs to exercise and nutrition. Therefore, we are currently addressing whether synchronizing exercise and nutrient interventions to the molecular circadian clock will maximize the health promoting benefits of exercise to enhance insulin sensitivity and mitochondrial biogenesis. This lecture will present new evidence highlighting exercise-responsive treatment targets and optimal exercise intervention strategies to mitigate secondary aging and prevent metabolic disease.

Host: Lena Claesson-Welsh