Yenan Bryceson, January 19


SciLifeLab The Svedberg seminar series

Monday, January 19

Yenan Bryceson

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Sweden

Yenan Bryceson received his his PhD from Karolinska Institutet in 2008 after working in the lab of Eric Long at the NIH, and is currently Assistant Professor at the Center for Infectious Medicine at Karolinska University. His lab studies the molecular mechanisms of cytotoxic lymphocyte differentiation and function in the context of primary immunodeficiencies, hematological malignancies and systemic onset autoimmunity. The goal is to develop better diagnostic procedures and treatments for patients suffering rare genetic diseases, while providing further understanding of the human immune system that may also benefit the therapy of common diseases caused by dysregulated immunity. Yenan’s is recipient of an ERC starting grant and was recently named Wallenberg Academy Fellow. In his spare time he enjoys hiking, skiing, fly fishing and is trying to figure out surfing.

 

Lymphocyte cytotoxicity illuminated by human primary immunodeficiency syndromes

Cytotoxic lymphocytes, including CD8+ cytotoxic T cells (CTL) and natural killer (NK) cells, can recognize and eradicate infected as well as transformed cells. Target cell killing is mediated through directed release of perforin-containing secretory lysosomes. Congenital defects in lymphocyte cytotoxicity are associated with early-onset, potentially fatal primary immunodeficiency syndromes characterized by hyperinflammatory conditions. Through studies of patients with suspected primary immunodeficiencies, our lab is gaining understanding of the molecular mechanisms underlying cytotoxic lymphocyte development, differentiation, and effector function. Providing novel insights to secretory lysosome release, we have identified non-coding mutations that regulate expression of protein isoforms required for secretory lysosome exocytosis. Moreover, other cell biological studies have uncovered a role for recycling endosome fusion in facilitating secretory lysosome exocytosis. This seminar will highlight recent advances in our knowledge of lymphocyte cytotoxicity and discuss implications for human health.

Host: Sebastian Barg