SERVICES

All contacts with the service facility are via the Head of Facility. There is always a meeting between the SMC and the customer, either in person or over the phone or Skype. At these meetings are also SMC's biostatistician present, and the staff that will perform analyzes. In some cases also the Facility director and/or deputy director is present.

• Untargeted metabolite profiling (metabolomics)
• Targeted metabolite profiling
  • g. amino acids, sugars, fatty acids, TMAO (for details, contact Head of Facility).
• Targeted lipid profiling (for details, contact Head of Facility).
• Study design
• Method development
• Basic statistics
• Open lab access services

APPLICATIONS

Metabolites are essential components in all living organisms. It is well known that disorders in metabolite patterns cause metabolic diseases that can have dramatic effects on the survival of the organism. Therefore is measuring metabolites essential in today’s clinical chemistry. In addition to use metabolite profiles for screening of metabolic disorders (clinical chemistry applications), targeted or untargeted profiling of metabolites or lipids are necessary also to understand fundamental biological processes. As metabolites can be considered as “end-points” and closer to the phenotype than e.g. transcript data, metabolite data provides biochemical information that can be linked to particular phenotypes. These links can then be used to connect to gene-, protein- or other meta-data in explorations of targeted biological processes, or also suggested to identify biomarkers.

EQUIPMENT

• Mass spectrometers
  • Leco Pegasus III, GCTOFMS
  • Leco Pegasus HT, GCTOFMS
  • Agilent 7000C, GCQqQMSMS
  • Thermo Scientific LTQ-Orbitrap XL
  • Agilent UHPLC-QqQMSMS 6495
  • Agilent UHPLC-QqQMSMS, 6490 (2)
  • Agilent 6550 iFunnel Accurate-Mass UHPLC-QTOFMSMS (2)
  • Agilent 6560 Ion Mobility UHPLC-QTOFMSMS