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DTSTART;TZID=Europe/Stockholm:20220915T180000
DTEND;TZID=Europe/Stockholm:20220915T190000
DTSTAMP:20260404T084805
CREATED:20220906T122422Z
LAST-MODIFIED:20220906T122503Z
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SUMMARY:Molecular analysis of human diversity and its impact on drug discovery using iPS cells
DESCRIPTION:Molecular analysis of human diversity and its impact on drug discovery using iPS cells \n\n\n\n \n\n\n\nWelcome to a lecture by Professor Angus I. Lamond\, \n\n\n\nUniversity of Dundee\, UK. \n\n\n\n16.00-17.00 Thursday September 15 \n\n\n\nAir & Fire (Gamma 2) or via zoom https://kth-se.zoom.us/s/69393882589 \n\n\n\n\n\n\n\nProfessor Lamond has over thirty years of experience as a Principal Investigator\, studying molecular mechanisms regulating gene expression and pre-mRNA splicing. This includes major contributions to the biochemical analysis of the human splicing machinery and to the study of functional compartments and subnuclear bodies in mammalian cells. The AIL group have developed new methods and technical approaches in these fields that have advanced mechanistic studies at the molecular and cellular levels\, spanning biochemical\, microscopy and MS-based proteomics technologies. During the past fifteen years\, the AIL laboratory has developed and applied state of the art mass spectrometry-based proteomic approaches in research projects studying molecular mechanisms regulating gene expression in both human cells and model organisms. This includes\, specifically\, integrated poly-omics analyses of human induced pluripotent stem cells (hiPSCs)\, derived from both healthy donors and patient cohorts with inherited disorders. Other studies have focused on proteome dynamics in the context of biological response mechanisms and ongoing studies identifying and characterizing small molecule modulators of alternative splicing and analysis of how splicing mechanisms affect cell proteomes\, protein isoform expression and resulting cell phenotypes. He will describe the progress in using both quantitative\, MS-based proteomics and high throughput imaging technologies to characterize libraries of human induced pluripotent stem cell (iPSC) lines\, derived from hundreds of different donors\, and show how comparisons of such iPSC lines can provide a novel approach for assessing mechanisms of variable drug response and help to deliver more safe new drugs that cater for the needs of diverse human populations. \n\n\n\nThis keynote lecture is part of the FEBS Advanced Course – Exploring the Human Proteome
URL:https://www.scilifelab.se/event/molecular-analysis-of-human-diversity-and-its-impact-on-drug-discovery-using-ips-cells/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220914T140000
DTEND;TZID=Europe/Stockholm:20220914T150000
DTSTAMP:20260404T084805
CREATED:20220905T092055Z
LAST-MODIFIED:20220906T122905Z
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SUMMARY:Systems Analysis of Human Metabolism for Identification of Drug Targets and Biomarkers
DESCRIPTION:Systems Analysis of Human Metabolism for Identification of Drug Targets and Biomarkers \n\n\n\nWelcome to a lecture by Professor Jens Nielsen\, \n\n\n\nBioinnovation Institute\, Copenhagen\, Denmark. \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nJens Nielsen is MSc in Chemical Engineering and PhD (1989) in Biochemical Engineering from the Danish Technical University (DTU). Fulbright visiting professor at MIT in 1995-1996. Professor at DTU in 1998. In 2008 he was recruited as Professor to Chalmers University of Technology\, Sweden. In 2015 he was founding Head of the Department of Biology and Biological Engineering\, which now encompass more than 200 people. Jens Nielsen was also a co-founder of the Novo Nordisk Foundation Center for Biosustainability that now have more than 300 people affiliated\, for which he served as CSO 2013-2018. From 2019 CEO of the BioInnovation Institute in Denmark\, which is a new institute financed by USD0.5B that fosters translational research and support new spin-out companies in life sciences. He has trained more than 280 scientists in his research group and published >850 publications that have been cited more than 98\,000 times (current H-factor 142). Inventor of >50 patents and founder of seven biotech companies. Has received numerous awards\, including the ENI Award\, the Eric and Sheila Samson Prime Minister Prize for Transportation Fuels\, the Novozymes Prize\, and the Gold Medal from the Royal Swedish Academy of Engineering Sciences. Member of 12 academies\, including NAS\, NAE\, Chinese Academy of Engineering\, EMBO and Royal Swedish Academy of Science. He will discuss the challenges of using systems medicine for advancing the development of personalized and precision medicine\, and it will be illustrated how the concept of genome-scale metabolic models can be used for integrative analysis of big data with the objective of identifying novel biomarkers that are foundational for personalized and precision medicine. \n\n\n\nThis keynote lecture is part of the FEBS Advanced Course – Exploring the Human Proteome
URL:https://www.scilifelab.se/event/systems-analysis-of-human-metabolism-for-identification-of-drug-targets-and-biomarkers/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220914T130000
DTEND;TZID=Europe/Stockholm:20220914T140000
DTSTAMP:20260404T084805
CREATED:20220905T091153Z
LAST-MODIFIED:20220906T122803Z
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SUMMARY:Mapping the development and regeneration of reproductive tissues
DESCRIPTION:Mapping the development and regeneration of reproductive tissues \n\n\n\nWelcome to a lecture by Roser Vento-Tormo\, Wellcome Sanger Institute\, UK. \n\n\n\n13.00-14.00 Wednesday September 14Air & Fire (Gamma 2) or via zoom https://kth-se.zoom.us/s/69393882589\n\n\n\n\n\n\n\nVento-Tormo’s research interest is to understand the influence of cellular microenvironments on individual cellular identities and responses\, in the context of development and immunity. Her team employs single-cell and spatial transcriptomics methods to deconstruct the cell signals in human organs and tissues\, and utilise this information to inform the reconstruction of novel in vitro models. Essential for this work\, is the novel computational tools her team develops to build cell–cell interactions networks from transcriptomics data. In her predoctoral research\, she studied the interplay between cell signalling and epigenetic machinery key to regulating cellular fate decisions in myeloid cells. She pursued her postdoctoral studies in the Teichmann laboratory as an EMBO / HFSP fellow\, where she developed CellPhoneDB.org\, a computational tool to study cell-cell communication from single-cell transcriptomics data. She used CellPhoneDB to disentangle the complex communication between maternal and fetal cells in the uterine-placental interface during early human pregnancy. Vento-Tormo work has been funded by many recognised international agencies (H2020\, MRC\, CZI\, Wellcome-LEAP)\, and she has recently obtained the Early Career Research Award from the Biochemistry Society (2021). \n\n\n\nThis keynote lecture is part of the FEBS Advanced Course – Exploring the Human Proteome
URL:https://www.scilifelab.se/event/mapping-the-development-and-regeneration-of-reproductive-tissues/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
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DTSTART;TZID=Europe/Stockholm:20220912T160000
DTEND;TZID=Europe/Stockholm:20220912T170000
DTSTAMP:20260404T084805
CREATED:20220905T092433Z
LAST-MODIFIED:20220914T005440Z
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SUMMARY:Clinical (phospho)-proteomics for precision medicine
DESCRIPTION:Clinical (phospho)proteomics for precision medicine \n\n\n\nWelcome to a lecture by Professor Connie R Jimenez\, Amsterdam University Medical Center\, Netherlands \n\n\n\n16.00-17.00 Monday September 12Air & Fire (Gamma 2) or via zoom https://kth-se.zoom.us/s/69393882589\n\n\n\n\n\n\n\nConnie Jimenez is Professor of Translational OncoProteomics at the Amsterdam University Medical Center in The Netherlands\, where she is heading the OncoProteomics Laboratory as well as the Proteomics Core Facility. \n\n\n\nShe is a molecular/cellular biologist with focus on the global analysis of the functional building blocks of life\, i.e.\, the proteins which activity and functions are highly deranged in disease. Her lab’s mission is to apply innovative mass spectrometry-based proteomics and data analysis to obtain systems biology insights into disease and to improve early diagnostics and treatment\, most notably of cancer and neurodegenerative disease. \n\n\n\nDuring her graduate studies at the Vrije Universiteit in Amsterdam (1993-1997)\, she pioneered single cell peptide profiling by mass spectrometry. During her post-doc in the Burlingame lab at UCSF\, San Francisco ((1997-1999)\, she applied proteomics to study neuron differentiation. In 2006\, she founded the OncoProteomics Laboratory (www.oncoproteomics.nl) with a start-up grant of the Cancer Center Amsterdam. \n\n\n\nTo date\, Dr. Jimenez (co)authored > 200 scientific peer reviewed articles. Underscoring her (inter)national esteem\, she founded the Netherlands Proteomics Platform in 2000 and is member of its steering board; she is general council member of the European Proteomics Association since 2005 and elected Vice-President since 2021; she is member of the steering committee of the Cancer HPP project of the Human Proteome Organisation. Finally\, she is editorial board member of several leading proteomics journals. \n\n\n\nThis keynote lecture is part of the FEBS Advanced Course – Exploring the Human Proteome
URL:https://www.scilifelab.se/event/clinical-phosphoproteomics-for-precision-medicine/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220911T080000
DTEND;TZID=Europe/Stockholm:20220916T170000
DTSTAMP:20260404T084805
CREATED:20220420T142106Z
LAST-MODIFIED:20220530T135853Z
UID:10000586-1662883200-1663347600@www.scilifelab.se
SUMMARY:Exploring the Human Proteome with Antibodies\, Transcriptomics and Mass Spectrometry
DESCRIPTION:The summer school is aimed at graduate students\, post-docs\, and young independent investigators who want to learn about new techniques to explore the proteins encoded by the human genome. The course will teach state-of-the-art analysis of the human proteins with a focus on antibody-based methods\, transcriptomics and mass spectrometry. The course will have several daily lectures by experts in the field and this will be complemented with workshops in which the participants will annotate genes/proteins. Each participant will take part in an annotation effort with the aim to go through all experimental evidence of the respective protein and to evaluate the quality of the underlying data to score the evidence for protein profiles and functionality. \n\n\n\nRead more\n\n\n\nThe course will be held at the Science for Life Laboratory located at the campus of Karolinska Institutet in proximity of the city center of Stockholm\, hosting researchers in the field of molecular bioscience affiliated with Karolinska Institutet\, Royal Institute of Technology and Stockholm University. The center has infrastructures for life science\, such as next generation sequencing\, proteomics\, single cell genomics\, bioimaging\, cryo-EM\, protein expression\, antibody engineering\, bioinformatics and systems biology. Accommodation and meals will be provided by the organizers. Social evenings and joined meals will provide ample opportunities for informal exchange with lecturers. \n\n\n\nMathias UhlenChair\, Organization Committee
URL:https://www.scilifelab.se/event/exploring-the-human-proteome-with-antibodiestranscriptomics-and-mass-spectrometry/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Course
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