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DTSTART;TZID=Europe/Stockholm:20250825T150000
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DTSTAMP:20260602T114046
CREATED:20250818T083625Z
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UID:10001581-1756134000-1756137600@www.scilifelab.se
SUMMARY:Functional Precision Medicine and Precision Immune Oncology Strategies
DESCRIPTION:Prof Taskén will cover research on functional precision medicine using cancer drug sensitivity screening to guide clinical decisions and on tumor immune evasion mechanisms aiming for future precision immune oncology approaches. \n\n\n\nBiography \n\n\n\nProfessor Kjetil Taskén has been key in building Norway’s national cancer precision medicine initiative\, now coordinates the Cancer Mission PRIME-ROSE project for DRUP-like clinical trials across Europe and will lead the Work Package on treatment in the Joint Action for Precision Cancer Medicine to start Nov 2025. He has authored>300 publications and is an inventor of >20 patents (h-index >70). He won the King Olav V’s Prize for Cancer Research in 2016\, the University of Oslo Innovation Prize in 2023\, the Oslo University Hospital Excellent Researcher Award in 2024\, and is Vice-President of the Norwegian Academy of Science and Letters. Current research is in tumor immune evasion mechanisms and functional precision medicine for different solid and blood cancers. Kjetil is also member of SciLifelab’s International Advisory Board (IAB). \n\n\n\nHost: Janne Lehtiö
URL:https://www.scilifelab.se/event/functional-precision-medicine-and-precision-immune-oncology-strategies/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
ORGANIZER;CN="Janne Lehti%C3%B6":MAILTO:janne.lehtio@scilifelab.se
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DTSTART;TZID=Europe/Stockholm:20221215T160000
DTEND;TZID=Europe/Stockholm:20221215T170000
DTSTAMP:20260602T114046
CREATED:20221212T155650Z
LAST-MODIFIED:20221212T155652Z
UID:10000749-1671120000-1671123600@www.scilifelab.se
SUMMARY:Functional analysis of human protein phosphorylation sites
DESCRIPTION:Matthias Selbach  \n\n\n\nPhosphoproteomics routinely quantifies changes in the levels of thousands of phosphorylation sites\, but functional analysis of such data remains a major challenge. I will present three different ways to characterise the function of human phosphorylation sites. First\, I will show how data from in vitro kinase assays can be used to predict kinase activity in phosphoproteomic datasets. Second\, I will show quantitative affinity purification experiments with synthetic phosphopeptides can help to assess their cellular function. Finally\, I will outline how quantitative RNA-interactome capture (qRIC) can quantify the fraction of cellular RNA-binding proteins that are pulled down with polyadenylated mRNAs. Combining qRIC with phosphoproteomics allows us to systematically compare pull-down efficiencies of phosphorylated and non-phosphorylated forms of RBPs. Using qRIC\, we identify over hundred phosphorylation sites with regulatory potential\, including known regulatory sites. Follow-up experiments on the cardiac splicing regulator RBM20 revealed that multiple phosphorylation sites in the C-terminal disordered region affect nucleo-cytoplasmic localisation\, association with cytosolic RNA granules and alternative splicing.      \n\n\n\nSelected publications\n\n\n\n\nVieira-Vieira\, CH\, Dauksaite\, V.\, Sporbert\, A.\, Gotthardt\, M. and Selbach M. (2022) Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20. Mol Cell 82\, 2069-2083.\n\n\n\nMeyer\, K.\, Kirchner\, M.\, Uyar\, B.\, Cheng\, J.Y.\, Russo\, G.\, …\, and Selbach\, M. (2018). Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs. Cell 175\, 239-253.\n\n\n\nImami\, K.\, Milek\, M.\, Bogdanow\, B.\, Yasuda\, T.\, Kastelic\, N.\, …\, and Selbach\, M. (2018). Mol Cell. Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis. Mol Cell 72\,\n\n\n\nZauber\, H.\, Kirchner\, M.\, and Selbach\, M. (2018). Picky: a simple online PRM and SRM method designer for targeted proteomics. Nat Methods 15\, 156-157.\n\n\n\nMcShane\, E.\, Sin\, C.\, Zauber\, H\, Wells JN\, Donnelly N\, …\, and Selbach M. (2016). Kinetic analysis of protein stability reveals age-dependent degradation. Cell 167\, 803-815.\n\n\n\nSchwanhausser\, B.\, Busse\, D.\, Li\, N.\, Dittmar\, G.\, Schuchhardt\, J.\, Wolf\, J.\, Chen\, W.\, and Selbach\, M. (2011). Global quantification of mammalian gene expression control. Nature 473\, 337-342.
URL:https://www.scilifelab.se/event/functional-analysis-of-human-protein-phosphorylation-sites/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Event
ORGANIZER;CN="Janne Lehti%C3%B6":MAILTO:janne.lehtio@scilifelab.se
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