BEGIN:VCALENDAR VERSION:2.0 PRODID:-//SciLifeLab - ECPv6.15.18//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:SciLifeLab X-ORIGINAL-URL:https://www.scilifelab.se X-WR-CALDESC:Events for SciLifeLab REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20220327T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20221030T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20230326T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20231029T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20250330T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20251026T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20260329T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20261025T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20270328T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20271031T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260324T150000 DTEND;TZID=Europe/Stockholm:20260324T160000 DTSTAMP:20260404T065451 CREATED:20260306T140203Z LAST-MODIFIED:20260306T140204Z UID:10001769-1774364400-1774368000@www.scilifelab.se SUMMARY:Application of advanced imaging technology for cell-type specific neural\, neuromodulatory and astrocytic signalling in vivo DESCRIPTION:Sofie Ährlund-Richter\, The Picower Institute for Learning and Memory\, Massachusetts Institute of Technology (MIT) \n\n\n\nTitle: Prefrontal Cortex Feedback Reshapes the Representation and Routing of Visual Information \n\n\n\nHow does the brain determine which sensory signals are behaviorally relevant\, and how are these signals routed across cortical networks? Top-down feedback from the prefrontal cortex (PFC) has long been proposed to play a central role in shaping sensory processing\, yet the circuit-level mechanisms by which distinct prefrontal pathways modulate sensory representations remain poorly understood. \n\n\n\nHere we investigate how anatomically and functionally distinct prefrontal subregions influence visual processing in primary visual cortex (VISp). Using a combination of axonal tracing\, two- photon calcium imaging\, and projection-specific chemogenetic perturbations in behaving mice\, we show that inputs from the anterior cingulate cortex (ACA) and orbitofrontal cortex (ORB) exert dissociable and context-dependent effects on visual responses. Our findings demonstrate that prefrontal feedback is not a uniform gain signal but instead operates through modular pathways that differentially shape sensory representations according to internal state and behavioral context. Building on these results\, we are developing next-generation in vivo approaches to uncover the cell-type-specific logic underlying cortical communication. By combining spectral unmixing–based two-photon imaging\, projection-defined labeling\, and targeted perturbations\, we can simultaneously image multiple\, defined VISp neuron populations distinguished by their long-range outputs. This strategy enables direct observation of how prefrontal feedback redistributes visual information across parallel cortical output channels in real time. \n\n\n\nTogether\, this work reveals how top-down control dynamically restructures sensory representations and routing in the cortex. By defining circuit principles of prefrontal modulation\, these findings provide a framework for understanding how disruptions in feedback control may contribute to altered perception and cognition in neurodevelopmental disorders. \n\n\n\nTalk 2:  \n\n\n\nIakovos Lazaridis\, McGovern Institute for Brain Research\, Massachusetts Institute of Technology (MIT) \n\n\n\nTitle: Striosomes and astrocytes shape striatal dopamine during behavioral state transitions \n\n\n\nAbstract: Basal ganglia circuits\, modulated by striatal dopamine\, support reinforcement learning\, action selection\, and behavioral flexibility. Integrating two independent lines of evidence\, we propose a framework in which striosomes set nigrostriatal output while dorsal striatal astrocytes gate local dopamine availability during behavioral state transitions. Using projection-defined circuit mapping and perturbations\, we show that striosomal D1 spiny projection neurons (SPNs) project directly to the substantia nigra pars compacta (SNpc)\, whereas striosomal D2 SPNs route indirectly via a central external globus pallidus node\, forming opponent pathways whose net influence on dopamine differs from matrix circuits. Astrocytes exhibit Ca²⁺ transients time-locked to SNpc-evoked dopamine release\, and selective astrocyte activation reduces subsequent dopamine availability without affecting spontaneous locomotion. In a probabilistic decision task\, large astrocytic Ca²⁺ events are enriched during disengagement and precede re-engagement; astrocyte signals predict upcoming state transitions and engagement more strongly than trial outcomes\, consistent with state-level regulation rather than action coding. Dopamine-dependent astrocytic adenosine release may provide a local mechanism for regulating dopamine availability while biasing D1/D2 signaling\, enabling flexible rebalancing of striatal output across behavioral states. Together\, these results link striosomal compartmental architecture to motivational control and reveal a glial gate on dopamine dynamics. \n\n\n\nHost: Iskra Pollak Dorocic URL:https://www.scilifelab.se/event/application-of-advanced-imaging-technology-for-cell-type-specific-neural-neuromodulatory-and-astrocytic-signalling-in-vivo/ LOCATION:Milkyway SciLifeLab Solna\, Tomtebodavägen 23\, Solna CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260323T140000 DTEND;TZID=Europe/Stockholm:20260323T150000 DTSTAMP:20260404T065451 CREATED:20260206T154723Z LAST-MODIFIED:20260313T100358Z UID:10001750-1774274400-1774278000@www.scilifelab.se SUMMARY:Decoding Enhancer-Mediated Gene Regulation with CAGE-seq and Deep Learning DESCRIPTION:Michiel de Hoon\, RIKEN center\, Japan \n\n\n\n\n\n\n\nAbstract\n\n\n\nPrecise regulation of gene expression is fundamental to cellular identity and behavior\, and gene dysregulation is a common feature across a wide variety of diseases.  At the molecular level\, this regulation is orchestrated by transcription factors acting on non-coding regulatory elements at promoters and distal enhancers. Genome-wide association studies have shown that disease-associated variants are enriched in enhancer elements\, and somatic mutations in these regulatory regions can contribute to diseases such as cancer. As it is often unclear how such variants influence gene expression\, connecting enhancers to their target promoters is a key step toward understanding the regulatory basis of pathogenic gene expression.Cap Analysis Gene Expression (CAGE-seq)\, originally developed at RIKEN\, provides an unbiased and quantitative genome-wide view of transcription initiation at single-nucleotide resolution. Beyond quantitating mRNAs and long non-coding RNAs\, CAGE-seq revealed widespread transcription at enhancers\, enabling their systematic identification and quantitative characterization. While traditional bioinformatics approaches have focused on genome annotation and expression analysis\, emerging neural network frameworks now enable inference of enhancer–promoter interactions directly from sequencing data. \n\n\n\nIn this presentation\, I will highlight the use of AI-based sequence-to-function frameworks that can predict transcriptional activity directly from genomic sequence. When combined with CAGE-seq\, these approaches enable the construction of context-specific regulatory maps linking enhancer activity to gene expression. Using examples from leukemia\, I will illustrate how CAGE-seq data\, analyzed using deep learning\, support a systematic interpretation of inter-patient heterogeneity in gene regulation. \n\n\n\nBiography\n\n\n\nI entered computational biology during my Ph.D. in Physics at the University of California\, Berkeley. After postdoctoral training in bioinformatics at the University of Tokyo and Columbia University\, I joined RIKEN in Yokohama\, where I became a core contributor to the FANTOM consortium\, an international effort to functionally annotate the mammalian genome. \n\n\n\nBetween 2014 and 2021\, I led the computational biology program of FANTOM6\, coordinating my research group and consortium-wide efforts to functionally annotate non-coding RNA. I am currently a tenured Senior Research Scientist at the RIKEN Center for Integrative Medical Sciences\, investigating gene regulatory mechanisms in disease\, particularly cancer. \n\n\n\nMore recently\, my research has focused on developing and applying AI-based sequence-to-function models to infer long-range gene regulatory interactions from genome and transcriptome data\, with the aim of understanding the regulatory basis of inter-patient heterogeneity in disease. \n\n\n\nHost: Pelin Sahlen pelin.akan@scilifelab.se URL:https://www.scilifelab.se/event/decoding-enhancer-mediated-gene-regulation-with-cage-seq-and-deep-learning/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260304T100000 DTEND;TZID=Europe/Stockholm:20260304T120000 DTSTAMP:20260404T065451 CREATED:20260121T151158Z LAST-MODIFIED:20260303T142729Z UID:10001730-1772618400-1772625600@www.scilifelab.se SUMMARY:Shaping the Future with Breakthrough Technologies in Healthcare DESCRIPTION:Breakthrough Technologies in Molecular Life Science to Power Precision Medicine and the Future of Healthcare in Sweden \n\n\n\nYou are warmly invited to a dialogue event with the aim of bringing together healthcare\, academia\, industry\, and other stakeholders to explore a national initiative for the future of translational healthcare in Sweden. \n\n\n\nBy 2035\, Sweden has the ambition to become a world leader in translating breakthrough biotechnology and AI into patient-centered healthcare. This event will discuss the vision for an excellence cluster that integrates SciLifeLab cutting-edge molecular life science technologies with AI-driven data analysis at university hospitals across the country. At its core are joint units where clinicians\, researchers\, and technology experts work side by side to accelerate diagnosis\, personalize treatment\, and enable data-driven clinical decision support. \n\n\n\nDuring the event\, we will present the preparatory project\, outline a national collaboration between research infrastructure\, healthcare systems\, and industry. The event will also address how this initiative can strengthen Sweden’s competitiveness\, attract investment and deliver benefits for patients and society.  \n\n\n\nRegister here\n\n\n\nWe look forward to welcoming you to a forward-looking dialogue on how together we can transform healthcare through breakthrough technologies and AI. \n\n\n\nRead more about SciLifeLabs work within translation to healthcare here. \n\n\n\nProgram\n\n\n\n09:30Coffee for onsite participants – outside “Torsten Wiesel”Karolinska university Hospital\, Solnavägen 30\, Solna10:00Introduction– Jan Ellenberg\, Director SciLifeLab– Mia Phillipson\, Co-Director SciLifeLab10:10Stakeholder Reflections– Annika Östman Wernerson\, President Karolinska Institutet– Mathias Axelsson\, Managing director medical diagnostics\, Karolinska University Hospital10:20Key objectives for translation to healthcare – data\, technology & innovationValtteri Wirta\, Päivi Östling\, Per Lek10:50Examples from translational projects – When symptoms are vague\, proteins can point the way\, Mikael Åberg\, Uppsala University\, Axel Rosell\, Karolinska Institutet and Charlotte Thålin\, Karolinska Institutet– Predicting  response to immunotherapy and antibody-drug conjugate therapy using Spatial Proteomics\, Charlotte Stadler\, KTH and Anders Ullén\, Karolinska Institutet11:15Panel discussion – Q&A11:45Summary & Next steps12:00Light lunch for on-site participants URL:https://www.scilifelab.se/event/shaping-the-future-with-breakthrough-technologies/ LOCATION:Torsten Wiesel\, Karolinska University Hospital\, Solnavägen 30\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2026/01/Translation-to-Healthcare-4-mars.png ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260226T000000 DTEND;TZID=Europe/Stockholm:20260226T235900 DTSTAMP:20260404T065451 CREATED:20260217T114852Z LAST-MODIFIED:20260217T115205Z UID:10001758-1772064000-1772150340@www.scilifelab.se SUMMARY:SciLifeLab PULSE - Q&A webinar for applicants DESCRIPTION:This is a Q&A webinar (two time options available) for general questions on the SciLifeLab PULSE application process. Find out more about the SciLifeLab PULSE postdoc program here The deadline for the 2nd SciLifeLab PULSE Call is March 16\, 2026! \n\n\n\n\n\n\n\n\n\n\n\nWebinar registration\n\n\n\n\n\nWebinar on February 26\, 2026\, at 09:00 am\, UTC+1 \n\n\n\n\n\nRegister here\n\n\n\n\n\n\n\nWebinar on February 26\, 2026\, at 16:00 pm\, UTC+1 \n\n\n\n\n\nRegister here URL:https://www.scilifelab.se/event/scilifelab-pulse-qa-webinar-for-applicants/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/12/AdobeStock_519582269-scaled-1.jpeg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260130T130000 DTEND;TZID=Europe/Stockholm:20260130T143000 DTSTAMP:20260404T065451 CREATED:20241220T095502Z LAST-MODIFIED:20260128T152020Z UID:10001421-1769778000-1769783400@www.scilifelab.se SUMMARY:Information seminar on KAW/SciLifeLab Proof of Concept call for grants 2026 DESCRIPTION:The 4th call for KAW/SciLifeLab Proof of Concept grants in Life Science is open for applications! \n\n\n\nThe purpose of the Proof of Concept grant is to bridge the gap from academic research to innovations in life science. The grant gives researchers the opportunity to develop their early-stage discoveries towards validated methods\, products or processes and  provides the opportunity to carry out activities that validate and accelerate the development of the project and prepare for innovation and commercialization. \n\n\n\nWatch the seminar below to learn more about the call. ↓ \n\n\n\nRegister to the Seminar\n\n\n\nProgram\n\n\n\n13.00The KAW/SciLifeLab Proof of Concept grants in Life Science\, Olli Kallioniemi\, Professor of Molecular Precision Medicine\, KI\, Lilian Wikström\, KAW13.20Project presentation – Marie Jeansson\, KITherapeutic intervention to slow progression of chronic kidney disease13.40Project presentation – Pål Stenmark\, Stockholm UniversityInnovative therapeutic toxins for the treatment of neuromuscular disorders14.00Open discussionModerator – Isolde Palombo\, KTH\n\n\n\nApplication period\n\n\n\nCall opens: January 13\, 2026Call closes: February 20\, 2026 at 13:00 \n\n\n\nRead more about the Call URL:https://www.scilifelab.se/event/information-seminar-on-kaw-scilifelab-proof-of-concept-call-for-grants-2026/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/12/Proof-of-Concept_bulb-in-center.png ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251218T000000 DTEND;TZID=Europe/Stockholm:20251218T235900 DTSTAMP:20260404T065451 CREATED:20251202T123921Z LAST-MODIFIED:20251202T124514Z UID:10001677-1766016000-1766102340@www.scilifelab.se SUMMARY:SciLifeLab PULSE - information webinar for applicants DESCRIPTION:This webinar (two time options available) gives PULSE applicants an opportunity to receive information on e.g. the matchmaking and application process\, as well as eligibility rules. There will also be time for Q&A:s. Find out more about the SciLifeLab PULSE postdoc program here The 2nd SciLifeLab PULSE Call opened on December 15! \n\n\n\n\n\n\n\n\n\n\n\nWebinar registration\n\n\n\n\n\nWebinar on December 18\, 2025\, at 09:00 am\, UTC+1 \n\n\n\n\n\nRegister here\n\n\n\n\n\n\n\nWebinar on December 18\, 2025\, at 16:00 pm\, UTC+1 \n\n\n\n\n\nRegister here URL:https://www.scilifelab.se/event/scilifelab-pulse-information-webinar-for-applicants/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/12/AdobeStock_519582269-scaled-1.jpeg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251216T151500 DTEND;TZID=Europe/Stockholm:20251216T161500 DTSTAMP:20260404T065451 CREATED:20251215T084843Z LAST-MODIFIED:20251215T084907Z UID:10001682-1765898100-1765901700@www.scilifelab.se SUMMARY:[Spotlight Seminar Series] The innate power of natural killer cells in cancer therapy DESCRIPTION:Professor Karl-Johan Malmberg (M.D. Ph.D) \, Oslo University \n\n\n\nBiography\n\n\n\nProfessor Karl-Johan Malmbergis a Specialist in Hematology with over 25 years of experience in NK cell research and cancer immunotherapy. He is the Director of a Norwegian Research Council Center of Excellence\, The Precision Immunotherapy Alliance (PRIMA) and leads an international team of 20 scientists based in laboratories both at the University of Oslo\, Norway and the Karolinska Institutet\, Sweden. He is also the Scientific Director of the Center for Advanced Cell and Gene Therapy (ACT) at Oslo University Hospital. The group focus on deciphering basic cellular and molecular mechanisms regulating NK cell function and seek to translate insights from these efforts in the design of novel approaches for NK-cell based cancer immunotherapy against cancer. \n\n\n\nRelevant Publications\n\n\n\nThe innate power of natural killer cells in cancer therapy. \n\n\n\nSohlberg E\, Malmberg KJ.Nat Med. 2025 Jun;31(6):1755-1756. doi: 10.1038/s41591-025-03712-9.PMID: 40355615 \n\n\n\nPan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping. \n\n\n\nNetskar H\, Pfefferle A\, Goodridge JP\, Sohlberg E\, Dufva O\, Teichmann SA\, Brownlie D\, Michaëlsson J\, Marquardt N\, Clancy T\, Horowitz A\, Malmberg KJ.Nat Immunol. 2024 Aug;25(8):1445-1459. doi: 10.1038/s41590-024-01884-z. Epub 2024 Jul 2.PMID: 38956379 \n\n\n\n \n\n\n\nHost: Adnane Achour adnane.achour@ki.se URL:https://www.scilifelab.se/event/spotlight-seminar-series-the-innate-power-of-natural-killer-cells-in-cancer-therapy/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251211T130000 DTEND;TZID=Europe/Stockholm:20251211T160000 DTSTAMP:20260404T065451 CREATED:20251027T112529Z LAST-MODIFIED:20251211T084725Z UID:10001654-1765458000-1765468800@www.scilifelab.se SUMMARY:Science & SciLifeLab Prize Scientific Symposium 2025 DESCRIPTION:Welcome to the Scientific Symposium where the winners of the 2025 Science & SciLifeLab Prize for Young Scientists will present their research! \n\n\n\nScience\, the American Association for the Advancement of Science (AAAS)\, and SciLifeLab joined forces in 2013\, creating the Science & SciLifeLab Prize for Young Scientists to recognize excellence amongst young researchers from around the world. A global Prize aimed at rewarding scientists at an early stage of their careers. \n\n\n\nThe Prize is awarded in four different categories and the winners will be announced on November 14th \n\n\n\n\nUche Medoh\, Grand Prize Winner in Molecular Medicine\n\n\n\nLiam Lachs\, Category Winner in Ecology and Environment\n\n\n\nNitzan Tal\, Category Winner in Genomics\, Proteomics\, and Systems Biology Approaches\n\n\n\nKing L. Hung\, Category Winner in Cell and Molecular Biology\n\n\n\n\nAll four winners of the Science & SciLifeLab Prize for Young Scientists are invited to Sweden December 8-13 to participate in a unique week filled with events in honor of science. They will have the opportunity to meet with leading scientists in their field of research and create life-long connections to support their careers. \n\n\n\n \n\n\n\nThe symposium will take place at beautiful Grand Hôtel in Stockholm. \n\n\n\nSeats are limited so register today for your chance to meet with the winners and the the AAAS/Science editor team AND our honorary guest\, the Grand Prize Winner from 2024\, Andrija Sente. \n\n\n\nRegistration\n\n\n\nProgram\n\n\n\nScience SciLifeLab Prize SymposiumDownload\n\n\n\nRead more about the Prize\n\n\n\nRead more about the winners URL:https://www.scilifelab.se/event/science-scilifelab-prize-scientific-symposium-2025/ LOCATION:Auditorium Stockholm\, Grand Hôtel\, Södra Blasieholmshamnen 8\, Stockholm\, 10327\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2020/05/prize_2018_puff.jpg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251125T151500 DTEND;TZID=Europe/Stockholm:20251125T163000 DTSTAMP:20260404T065451 CREATED:20251110T125804Z LAST-MODIFIED:20251112T145847Z UID:10001662-1764083700-1764088200@www.scilifelab.se SUMMARY:[Spotlight Seminar Series] Molecular Mechanisms Underlying the Energy Currents of Life DESCRIPTION:Spotlight seminar series proudly welcomes Professor Vile R. I. Kaila to give a seminar at SciLifeLab Campus Solna. \n\n\n\n\n\n\n\nBiography\n\n\n\nVille R. I. Kaila received his PhD in biochemistry in 2009 from University of Helsinki. After a postdoc at the US National Institutes of Health (NIH)\, he was appointed a professorship at the Technical University of Munich in 2013. In 2019\, Kaila moved with his research group to Stockholm\, where he is currently professor at the Department of Biochemistry and Biophysics at Stockholm University and a Wallenberg Scholar. His research focuses on elucidating mechanistic principles of bioenergetic enzyme complexes by development of integrative computational and experimental approaches. Read more at http://villekaila.com/ \n\n\n\nAbstract\n\n\n\nBiological energy conversion is catalyzed by intricate protein complexes that transduce redox energy into proton currents across a biological membrane\, powering the cellular energy metabolism. Yet\, despite significant advances in recent years\, the molecular principles of these reactions remain poorly understood and pose major scientific challenges. In this talk\, I describe our integrative mechanistic exploration of complex bioenergetic machines\, where we combine multiscale simulations and data-driven methods with biophysical experiments and structural (cryo-EM) studies to derive a molecular understanding of intricate long-range charge transfer reactions in biology on a broad range of timescales and spatial resolutions. I describe our recent work on understanding enzymes catalyzing long-range charge transfer reaction by intrinsic electric field effects. We find that mutations of key residues mediating these allosteric processes lead to perturbed coupling effects\, and development of severe human diseases\, with striking similarities in different biological systems. \n\n\n\n \n\n\n\nHost: Marta Carroni marta.carroni@scilifelab.se URL:https://www.scilifelab.se/event/spotlight-seminar-series-molecular-mechanisms-underlying-the-energy-currents-of-life/ LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251021T153000 DTEND;TZID=Europe/Stockholm:20251021T170000 DTSTAMP:20260404T065451 CREATED:20251013T140805Z LAST-MODIFIED:20251013T140807Z UID:10001635-1761060600-1761066000@www.scilifelab.se SUMMARY:Molecular Mechanism of RNA Splicing by the Spliceosome DESCRIPTION:Seminar by Yigong ShiWestlake University\, Hangzhou\, Zhejiang 310024\, China \n\n\n\nHost: David Drew\, SciLifeLab \n\n\n\nSplicing of the precursor messenger RNA (pre-mRNA) is an indispensable step in the information flow from DNA to protein in all eukaryotes. Research of the past four decades has led to accumulation of a large body of biochemical and genetic information on pre-mRNA splicing. Structural information is central to the elucidation of the molecular mechanism of pre-mRNA splicing by the spliceosome. In 2015\, we reported the first atomic structure of an intact spliceosome from S. pombe at an average resolution of 3.6 Å. This structure reveals the overall organization and the conserved atomic features of an intact spliceosome\, which turns out to be a protein-orchestrated metalloribozyme. Since then\, atomic structures have been reported for nearly all major functional states of the spliceosome\, allowing recapitulation of the entire splicing cycle and mechanistic understanding of RNA splicing. In this presentation\, I will summarize these advances and discuss implications on disease treatment. URL:https://www.scilifelab.se/event/molecular-mechanism-of-rna-splicing-by-the-spliceosome/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251016T090000 DTEND;TZID=Europe/Stockholm:20251016T170000 DTSTAMP:20260404T065451 CREATED:20250912T085114Z LAST-MODIFIED:20251016T111054Z UID:10001613-1760605200-1760634000@www.scilifelab.se SUMMARY:Campus Solna Science Talks 2025 DESCRIPTION:Warmly welcome to the sixth Campus Solna Science Talk – a meeting for everyone in the community to learn more about ongoing research and activities at SciLifeLab’s Campus Solna\, which aims to bring the community together\, inspire exchange and new collaborations. \n\n\n\nResearch presentations will be given by group leaders and junior researchers (selected with consideration for balance in topics\, presenters’ career stages\, and affiliations) as part of four plenary sessions that will be mixed with panel discussions. We will end the day at Delta Campus Solna with poster sessions and pub. \n\n\n\nWe invite all Campus Solna research groups to be represented with at least 1 poster (and maximum 3). Furthermore\, we want to encourage all infrastructure units\, support functions (IT\, OO\, Site support) and committees (DEI\, Public Engagement\, CSI and the PhD&Postdoc Council) to partake with posters! \n\n\n\nSeats are limited\, register today to secure your spot! \n\n\n\nRegistration\n\n\n\n\n\n\n\nProgram\n8.45Welcoming and opening of symposiumPer Ljungdahl and Jan Ellenberg9.00Session I: Molecular profilingModerator: Erik Benson9.05Nanoscale detection and chemical targeting of DNA replication at its rootBennie Lemmens9.20Illuminating DNA-RNA connectomes in single cellsMagda Bienko9.35Proteome-wide biophysicsIlaria Piazza9.50Systematic Profiling of GPCR Autoantibodies in Human DiseaseMarcus Saarinen (Jochen Schwenk lab)10.10Coffee10.40Session II: Environment and EvolutionModerator: Christopher Wheat10.45Climate-Driven Trends in Adaptive Molt PhenologyTheodore Squires (Mafalda Sousa Ferreira lab)11.00Genomics of island lineages: A data-driven approachJose Cerca (DDLS Fellow)11.15How Development Makes Evolution More PredictableLisandro Milocco (DDLS fellow)11.35Putting CoARA and Research Assessment Reform into Practice: What It Means for SciLifeLab and Swedish ResearchChris Erdmann\, Annika Jenmalm Jensen\, Joanna Sendecka12.05Lunch12.50Session III: Membrane biology and molecular networksModerator: Rebecca Howard12.55Towards structure-guided design of mRNA lipid nanoparticlesWojciech Fijalkowski (Hanna Barriga lab)13.10Using biophysical properties of immune cells to find unifying biomarkers in long COVID and Chronic Fatigue Syndrome (ME/CFS)Agnes M. Koerfer (Erdinc Sezgin lab)13.25Combining cryo-EM and simulations to study membrane structureKaran Sharma (Milka Doktorova lab)13.40From Nodes to Distributed States: Tools to Decode Mammalian BehaviorStefanos Stagkourakis14.00Leg stretch and Coffee14.20Session IV: Machine learning and drug development Moderator: Brinton Seashore-Ludlow14.25PRIME: Investigating the role of PRostate Inflammation as a Mechanism for Cancer EvolutionAlexandra Rafeletou (Arian Lundberg lab)14.40Machine Learning methods for Cancer Research & Drug DiscoveryGolnaz Taheri14:55Navigation of vast chemical spaces for drug discoveryAndreas Luttens15.10Towards clinically reliable artificial intelligence for prostate cancer pathologyNita Mulliqi (Kimmo Kartasalo lab)15.30Panel: Evolution of SciLifeLab – 15 years! From Past into the FutureModerators; Rebecca Howard and Erdinc Sezgin16.00Concluding remarksPer Ljungdahl16.15Poster session and Pub at Campus Solna\n\n\n\n\nPosters\nThere will be voting for the Best Poster Award in two different categories; “Best Design and Presentation” and “Highest Scientific Impact”. The winners will be announced towards the end of the poster session. \n\n\n\n \n\n\n\nEach group/unit is welcome to bring up to 3 posters to the grand Poster Session that will follow the talks. Submit the poster titles in the registration form. Please coordinate within your research group/unit beforehand who should bring a poster. \n\n\n\nPlease add your building and floor to the poster\, so that everyone knows where your research is taking place. \n\n\n\nPoster size; A0 or smaller in portrait orientation \n\n\n\nPosterlista Science Talks 2025Download\n\n\n\n\nScientific committee\nInci Aksoylu \n\n\n\nHaris Babačić \n\n\n\nIskra Pollack \n\n\n\nAdnane Achour \n\n\n\nErik Benson \n\n\n\nPer Ljungdahl \n\n\n\nOrganising committe\n\n\n\nDisa Hammarlöf \n\n\n\nIsolde Palombo URL:https://www.scilifelab.se/event/campus-solna-science-talks-2025/ LOCATION:Life City\, Solnavägen 3H\, Stockholm\, 113 64 CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2022/09/Fasad-SciLifeLab-Solna-2022-2-1-scaled.jpeg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251002T150000 DTEND;TZID=Europe/Stockholm:20251002T160000 DTSTAMP:20260404T065451 CREATED:20250926T084640Z LAST-MODIFIED:20250926T084643Z UID:10001620-1759417200-1759420800@www.scilifelab.se SUMMARY:Basic and Translational Research on Fungal-Host Interactions DESCRIPTION:Changbin Chen\, Professor \n\n\n\nUnit of Pathogenic Fungal Infection & Host ImmunityShanghai Institute of Immunity and Infection\, Chinese Academy of Sciences\, Shanghai\, China \n\n\n\nProf. Changbin Chen is visiting SciLifeLab Campus Solna as part of a NSFC and STINT funded collaboration with the Ljungdahl laboratory.  \n\n\n\nProject:  Role of amino acid acquisition and catabolism as drivers of virulent Candida auris infections. \n\n\n\nThe Shanghai Institute of Immunity and Infection has assembled an impressive array of analytic infrastructures\, similar in breath available at SciLifeLab\, to address mechanistic aspects of infectious disease. \n\n\n\nProf. Chen will present how his laboratory and collaborators examine the virulence properties of fungal pathogens in context of mammalian hosts. \n\n\n\nHost: Per Ljungdahl \n\n\n\nRoom: Big URL:https://www.scilifelab.se/event/basic-and-translational-research-on-fungal-host-interactions/ LOCATION:SciLifeLab Campus Solna\, Tomtebodavägen 23 A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251001T090000 DTEND;TZID=Europe/Stockholm:20251001T170000 DTSTAMP:20260404T065451 CREATED:20241101T094230Z LAST-MODIFIED:20250929T172603Z UID:10001393-1759309200-1759338000@www.scilifelab.se SUMMARY:Disruptive Technologies for Drugging the Undruggable DESCRIPTION:SciLifeLab Science Summit 2025 \n\n\n\n\n\n\n\nAre you ready to explore the cutting-edge for the future of drug discovery? Mark your calendar for the SciLifeLab Science Summit 2025\, an event focusing on novel technologies as drivers to find new modalities for disease intervention and drug innovation for precision medicine. \n\n\n\nThis full-day symposium will bring together leading scientists\, industry experts\, and innovators to discuss the breakthroughs and challenges in addressing previously inaccessible drug targets. Join us at Aula Medica\, Karolinska Institutet\, for a packed program featuring high-impact international presentations\, panel discussions\, and networking opportunities. \n\n\n\nJunior researchers are encouraged to participate with poster presentations – with the opportunity to be selected to give a short talk. \n\n\n\nProgram\n\n\n\n08:45Registration09:30Welcome wordsIntroduction of the day09:40SciLifeLab – a fertile ground for innovationMia Phillipson\, SciLifeLab09:50Any target\, every time: how proximity-based drugs are redefining pharmacotherapyRay Deshaies\, Amgen / Caltech10:40Coffee break & poster session ISee Poster List & Abstracts here11:25Applying lessons learned from Duchenne exon skipping dystrophy to developing exon skipping for patients with nanorare diseasesAnnemieke Aartsma-Rus\, Leiden University Medical Center12:00Oligonucleotide therapy – from bench to besideAnders Gabrielsen\, Ribocure Pharmaceuticals12:10Empowering immunotherapy with cellular reprogrammingFilipe Pereira\, Lund university12:20Conclusions12:30Lunch & Poster Session13:40AI and machine learning for next-generation drug discoveryEva Nittinger\, AstraZeneca14:10Electrophoretic Implants for in situ Precision MedicineTheresia Arbring Sjöström\, Linköping University14:15Integrated Hit Discovery Pipeline Targeting Protein–Protein InteractionsFlorian David\, Chalmers University of Technology14:20Employing CETSA in primary screening for P53 bindersMerve Kacal\, Pelago Bioscience AB14:25Capturing Conformational Change : A Strategy for Drugging Dynamic Transporters\, Receptors and Ion ChannelsDarko Mitrovic\, KTH Royal Institute of Technology14:30Conclusions14:40Coffee break & poster session IISee poster list and abstract here15:30Encoded combinatorial libraries and the dream of Paul EhrlichDario Neri\, Philogen / ETHZ16:00The 2025 Drug Discovery and Development PipelineJessica Martinsson\, SwedenBio16:20Panel discussion16:40Wrap-up\, best poster award17:00Mingle\n\n\n\nPrintable program Science Summit 2025Download\n\n\n\n\n\n\n\nResearch Infrastructures and Research Posters\n\n\n\nPoster abstract book\, Science Summit 2025Download\n\n\n\nCompany Exhibition\n\n\n\n15 companies will present their technologies in the exhibition area. \n\n\n\nBICO\, Epistat\, Sino Biological Europe GmbH\, Chempartner\, Ramcon\, Twist Bioscience\, Shimadzu\, Teknolab Sorbent AB\, BioNordika Sweden AB\, Berner Lab\, Kem-En-Tec Nordic \, Eppendorf Nordic\, LabLife Nordic  \n\n\n\n\n\n\n\n\n\n \n\n\n\nScientific Committee\n\n\n\n\nClaes Wahlestedt\, University of Miami\n\n\n\nMalin Lemurell\, AstraZeneca\n\n\n\nAlexandra Teleki\, Uppsala University\n\n\n\n\n \n\n\n\n\n\n \n\n\n\nOrganizing Committee\n\n\n\n\nPer Arvidsson\, Karolinska Institutet/SciLifeLab\n\n\n\nRebecka Klintenberg\, Uppsala University/SciLifeLab\n\n\n\nMats Ohlin\, Lund University/SciLifeLab\n\n\n\nKristian Sandberg\, Uppsala University/SciLifeLab\n\n\n\nContact: David Gotthold\, SciLifeLab URL:https://www.scilifelab.se/event/drugging-the-undruggable-scilifelab-science-summit-2025/ LOCATION:Aula Medica\, Nobels väg 6\, Solna CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2024/11/Webpuff-Science-Summit-2025.png ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250923T151500 DTEND;TZID=Europe/Stockholm:20250923T161500 DTSTAMP:20260404T065451 CREATED:20250908T101407Z LAST-MODIFIED:20250908T101409Z UID:10001612-1758640500-1758644100@www.scilifelab.se SUMMARY:[Spotlight seminar] Systems Human Immunology and AI: Immune Setpoint and Immune Health DESCRIPTION:Speaker: Professor John Tsang\, Yale University \n\n\n\nAbstract\n\n\n\nThe immune system\, critical for human health and implicated in many diseases\, defends against pathogens\, monitors physiological stress\, and maintains tissue and organismal homeostasis. It exhibits substantial variability both within and across individuals and populations. Recent technological and conceptual progress in systems human immunology has provided predictive insights that link personal immune states to intervention responses and disease susceptibilities. Artificial intelligence (AI)\, particularly machine learning (ML)\, has emerged as a powerful tool for analyzing complex immune data sets\, revealing hidden patterns across biological scales\, and enabling predictive models for individualistic immune responses and potentially personalized interventions. Here I light our recent work in deciphering human immune variation and predicting outcomes\, particularly through the concepts of immune setpoint\, immune health\, and use of the immune system as a window for measuring health.  \n\n\n\nBiography\n\n\n\nJohn Tsang is a systems immunologist\, computational biologist\, and engineer. He is the Anthony N. Brady Professor of Immunobiology and Biomedical Engineering at Yale University\, the Founding Director of the Yale Center for Systems and Engineering Immunology (CSEI)\, the Yale Lead and an Investigator at the Chan Zuckerberg Biohub New York\, and the co-Chief Scientific Officer of the Human Immunome Project (a non-profit dedicated to mapping human immune variation around the globe to develop AI models of human immune health for the benefit of all). Tsang has pioneered and established the concepts and predictive metrics of human immune setpoints and immune health including responses to vaccines\, infections\, autoimmunity\, and therapeutics in human populations spanning the lifespan from infancy to old age. Tsang is also interested in programming immune cells to enable longitudinal immune and health monitoring of the entire body. Tsang has received numerous awards including multiple NIH Merit Awards for his research and leadership in systems immunology\, COVID-19\, and human immunology. He has advised numerous programs and organizations\, including the Allen Institute\, the Gates Foundation\, CEPI\, World Allergy Organization\, National Cancer Institute\, National Institute of Allergy and Infectious Diseases\, National Institute of Diabetes and Digestive and Kidney Diseases\, Snow Medical (Australia)\, and the Walter and Eliza Hall Institute (Australia). Tsang earned his Ph.D. in biophysics from Harvard University and trained in computer engineering (BASc) and computer science (MMath) at the University of Waterloo\, Canada.  \n\n\n\nHost: burcu.ayoglu@scilifelab.se URL:https://www.scilifelab.se/event/spotlight-seminar-systems-human-immunology-and-ai-immune-setpoint-and-immune-health/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250918T110000 DTEND;TZID=Europe/Stockholm:20250919T130000 DTSTAMP:20260404T065451 CREATED:20241101T121408Z LAST-MODIFIED:20250918T033327Z UID:10001394-1758193200-1758286800@www.scilifelab.se SUMMARY:SciLifeLab Group Leader Retreat DESCRIPTION:To SciLifeLab Group Leaders: Join us at this enriching retreat to contribute to a collaborative culture and advance cutting-edge life science research in Sweden and beyond. \n\n\n\nThis retreat offers SciLifeLab Group Leaders an opportunity to come together in an informal setting\, exchange ideas\, and explore opportunities for collaboration that transcend the boundaries of individual disciplines\, universities\, and research units. The program will focus on three key themes: \n\n\n\nThe registration is closed! \n\n\n\nThe Future of Life Science \n\n\n\nKeynote: Jan Ellenberg\, SciLifeLab Director – “Future of Life Sciences”. Panel Talk\, Audience Interaction\, and Group Discussions. Moderator: Ola Spjuth. \n\n\n\nSciLifeLab Development of and Access to Cutting-Edge Technologies \n\n\n\nInspirational Talks in Thematic areas followed by Group Discussions. \n\n\n\n\nSpatial Omics – EventArenaModerators: Markus Heidenblad and Stefania Giacomello. Speaker: Charlotte Stadler\n\n\n\nTechnology for Biodiversity – Wijk 1Moderators: Mafalda Sousa Ferreira and Gabriela Montejo-Kovacevich. Speaker: Marc Friedländer\n\n\n\nAI & Modelling – Wijk 4Moderators: Carolina Wählby and Björn Wallner. Speaker: Gunnar Cedersund\n\n\n\nImaging Structure Function In Situ / Cryo-EM / Organoids – Wijk5 Moderators: Linda Sandblad and Gunnar von Heijne. Speaker: Marta Carroni\n\n\n\n\nLeadership into the Future \n\n\n\nKeynote: Ronnie Berntsson\, Umeå University. Interactive group exchanges on leadership strategies. Moderator: Bianca Stenmark and Valtteri Wirta. \n\n\n\nDetails:\n\n\n\nDate: September 18-19\, 2025 \n\n\n\nStart: Sept. 18 at 10:00 \n\n\n\nEnd: Sept. 19 at 15:00 \n\n\n\nVenue: Skogshem & Wijk\, Lidingö\, Stockholm (map) \n\n\n\nFind your way! How to get there and a map of the Venue\, including parking spaces. \n\n\n\nBusses\n\n\n\nTo Skogshem & Wijk – September 18 FromDepartureSciLifeLab Uppsala (BMC)\, Husargatan 3\, entrance C1108:45Stockholm\, Cityterminalen09:30Stockholm\, Cityterminalen11:00From Skogshem & Wijk – September 19 ToDepartureSciLifeLab Uppsala (BMC)\, Husargatan 3\, entrance C1115:30Stockholm\, Cityterminalen15:30\n\n\n\n\n\n\n\n \n\n\n\n \n\n\n\nGroup leader retreat_program_cleanDownload URL:https://www.scilifelab.se/event/scilifelab-group-leader-retreat-2/ LOCATION:Skogshem & Wijk\, Hustegavägen 1\, Lidingö\, 181 24 CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/11/Skogshem-wijk-view.jpeg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250903T080000 DTEND;TZID=Europe/Stockholm:20250907T170000 DTSTAMP:20260404T065451 CREATED:20250313T121551Z LAST-MODIFIED:20250827T164834Z UID:10001507-1756886400-1757264400@www.scilifelab.se SUMMARY:40th Small Meeting on Yeast Transport and Energetics DESCRIPTION:Join in on a Historic SMYTE in Stockholm! \n\n\n\nFor the first time\, the Small Meeting on Yeast Transport and Energetics (SMYTE) is coming to Scandinavia! From September 3–7\, 2025\, Stockholm—a city renowned for scientific excellence and innovation—will host the 40th edition of SMYTE\, bringing together a focused group of international researchers. Sweden has a longstanding tradition in yeast and membrane biology\, making it a fitting location to celebrate the profound impact of yeast research on modern biology. The very word “enzyme” derived from the Greek énzymon (“in yeast”) is a testament to yeast’s historical significance in science. Our venue\, Münchenbryggeriet (The Munich Brewery)\, symbolizes the deep-rooted connection between yeast and European Breweries\, which have contributed extensively to the understanding of essential life processes. \n\n\n\nWhy Attend?\n\n\n\nThis landmark SMYTE\, building on four decades of success\, promises an exciting and forward-thinking scientific program featuring cutting-edge\, unpublished research from leading experts in the field. Plenary and Keynote talks will address pressing biological questions\, including those relevant to pathogenic fungi\, with implications for global health and biotechnology—areas where our community is making significant strides. \n\n\n\nWhat’s in Store?\n\n\n\nParticipants will explore the latest discoveries in transport and energetics\, delving into the structure\, function\, and regulation of transport systems across yeast and fungal membranes. Dynamic and emerging topics include homeostasis\, stress physiology\, evolution\, drug resistance\, and bioenergetics\, all of which hold promise for advancing both fundamental science and applied research. \n\n\n\nBeyond the scientific program\, interactive poster sessions and ample networking opportunities will foster collaborations and career development\, rejuvenating and strengthening the yeast research community working in the broad areas of transport and energetics\, sizzingly HOTareas of fundamental importance to \n\n\n\nunderstanding life. Set against the stunning backdrop of Stockholm\, arguably the “Capital of Scandinavia\,” this SMYTE will not only push us scientifically but also offer a unique opportunity to experience Sweden’s rich heritage and vibrant culture. \n\n\n\nDon’t Miss Out! \n\n\n\nWe invite participation from members of the fungal research community at all career stages\, early career researchers\, postdocs\, and students are especially encouraged to submit abstracts for both oral and poster presentations.  With only 120 spots available\, we urge you to register\, submit your abstract\, and secure your place! \n\n\n\nWe are excited to welcome you to Stockholm in September! \n\n\n\nThe 40th SMYTE – Stockholm Organizing Team \n\n\n\nPer Ljungdahl and David Drew \n\n\n\nImportant dates\nImportant Dates \n\n\n\n• Abstract submission opens March 24 \n\n\n\n• Deadline Abstracts considered for oral presentations June 4 \n\n\n\n• Notification of Abstracts accepted for oral presentations June 16 \n\n\n\n• Early Bird Registration June 23 \n\n\n\n• Meeting Registration and Late Poster Abstract Submission Closes – August 11 \n\n\n\n\nRegistration\nConference fees \n\n\n\n Fee until 23 June 2025     Fee from 24 June 2025Academic/Principal Investigator6500 SEK 6900 SEK Postdocs/Students5600 SEK6000 SEK Industrial Associate7500 SEK 7900 SEK\n\n\n\n                                    \n\n\n\nPlease note: All conference fees above are in SEK excluding VAT. According to the Swedish and EU legislation\, 25% VAT will be added to the conference fees. In some cases\, however\, VAT is not applicable. Please read carefully the information below.. \n\n\n\nThe conference fee includes: Access to all conference lectures\, conference program and materials\, lunch and refreshments\, drinks and snacks during the poster sessions\, evening meals on Wednesday\, Thursday and Saturday. Last day for registration is 11 August\, 2025. \n\n\n\nRegister here\n\n\n\nPayment InformationDownload\n\n\n\n\nAccommodation\nPlease note: You will need to book accommodations.  \n\n\n\nThe cost for accommodations can vary. Three hotels located close to the venue are available for booking\, governmental rates apply ( ≈ 2 600 SEK per night).  \n\n\n\nBudget alternatives are available – book using your favorite web-based application\, e.g.\, Booking.com (may reduce fees). Recommendation is to search for accommodations in the Södermalm or Gamla Stan areas of Stockholm located within easy walking distance to the meeting venue Münchenbryggeriet. Availability may be limiting – good to book as soon as possible. \n\n\n\nHotel infoDownload\n\n\n\n\nAbstract submission\nTo submit your abstract you will need to create an account to get access to the submission server. \n\n\n\nIn preparing your abstract\, please note the following:Abstract Title: max 150 characters including spacesAbstract text: max 350 words (excluding title\, authors and affiliation) \n\n\n\nIndicate preference: Oral\, Poster\, or No Preference  \n\n\n\nIndicate a topic that best fits your contribution \n\n\n\nIndicate if as presenting author\, you are a young investigator (PhD or Postdoc) eligible for Best Oral Presentation and Best Poster Presentation awards \n\n\n\nSubmit your Abstract Here\n\n\n\n\nPrevious meetings\nSMYTE History \n\n\n\n\n\n\n\n\n\n\n\n\nThe venue\nSeminars\, poster sessions\, and most meals will be held on site at the Münchenbrggeriet (Munich Brewery) centrally located in Stockholm\, now converted into a lovely conference center in the heart of Stockholm\, with a breathtaking veiw of the city. “A historical building completely refurbished – right by the sea with the best view.” Our venue is Magasinet\, Södermälarstrand 25 that accommodates 120 participants\, well suited for the wonderful SMYTE community.  \n\n\n\n\n\n\n\nIt is highly appropriate to have our meeting at an old brewery. Some of you may not know\, European Breweries funded major research efforts during the first half of the 1900’s and their impactful findings laid the foundation of modern biochemical and genetic analysis. The groundbreaking work carried out at these breweries contributed to making yeast one the best understood forms of life. In our work today\, our use of yeast and fungi as experiemental models builds on a strong tradition of research aimed at obtaining a precise appreciation of the many remaining mysteries of life.  \n\n\n\nStockholm is easily accessible by air and train service and is a great base should you want to extend your stay and vacation in conjunction with your participation at the 40th SMYTE. \n\n\n\n\nProgram\n\n\n\n\nProgram_final20250826Download\n\n\n\n \n\n\n\nAdditional Highlights\n\n\n\nPoster – Networking Sessions \n\n\n\nBest Poster – Best Presentation by young researchers (PhD or Postdoc) \n\n\n\n\nGeneral Information\nFor general useful practical information regarding weather\, currency etc. \n\n\n\nThe information will be updated with travel information – ground transportation. \n\n\n\nGeneral InformationDownload\n\n\n\nSpecific information including turist information regarding Stockholm.  \n\n\n\nInformation StockholmDownload\n\n\n\nArrival information \n\n\n\nSMYTE Arrival InfoDownload\n\n\n\n\nSponsors\nSponsorPage_final20250826Download\n\n\n\n\nOrganisers\nPer Ljungdahl per.ljungdahl@scilifelab.se \n\n\n\nDavid Drew david.drew@scilifelab.se URL:https://www.scilifelab.se/event/40th-small-meeting-on-yeast-transport-and-energetics/ LOCATION:Magasinet\, Söder Mälarstrand 25\, Stockholm\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2025/03/Picture-1.png ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250211T123000 DTEND;TZID=Europe/Stockholm:20250211T153000 DTSTAMP:20260404T065451 CREATED:20250129T095244Z LAST-MODIFIED:20250129T140732Z UID:10001463-1739277000-1739287800@www.scilifelab.se SUMMARY:Changes and Challenges through the Ages DESCRIPTION:Be part of an empowering and enlightening discussion featuring trailblazing Women in Research as we celebrate International Day of Women and Girls in Science on February 11 at BMC\, Uppsala\, in room B7:101a. \n\n\n\nThis panel brings together accomplished research professionals to share their journeys\, challenges\, and triumphs in breaking barriers and advancing innovation. \n\n\n\nOrganizer: Vijay Sai Josyula\, Christoffersson Lab\, Uppsala University\, in cooperation with SciLifeLab Site Uppsala. \n\n\n\nGuest Speakers \n\n\n\n\nKeynote speaker. Prof. Mia Phillipson\n\n\n\nDr. Gabriela Montejo-Kovacevich\n\n\n\nDr. Kaska Koltowska\n\n\n\nDr. Jessica Nordlund\n\n\n\nDr. Amy Turner (Proteintech)\n\n\n\n\n\n\n\n\nProgram\n\n\n\n12:30             Welcome \n\n\n\n12:45             Introduction to the company Proteintech \n\n\n\n13:00             Keynote speaker Prof. Mia Phillipson \n\n\n\n13:30             Dr. Gabriela Montejo-Kovacevich \n\n\n\n13:45             Dr. Kaska Koltowska \n\n\n\n14:00             Break / Networking session \n\n\n\n14:10             Dr. Jessica Nordlund  \n\n\n\n14:25             Dr. Amy Turner\, Proteintech \n\n\n\n14:40             Panel Discussion \n\n\n\n15:30             Closing statements \n\n\n\n\n\n\n\nRegistration URL:https://www.scilifelab.se/event/changes-and-challenges-through-the-ages/ LOCATION:BMC Room B7:101a\, Husargatan 3\, Uppsala CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250123T000000 DTEND;TZID=Europe/Stockholm:20250123T235959 DTSTAMP:20260404T065451 CREATED:20250108T142522Z LAST-MODIFIED:20250108T143218Z UID:10001428-1737590400-1737676799@www.scilifelab.se SUMMARY:SciLifeLab PULSE - information webinar for applicants DESCRIPTION:This webinar (two time options available) gives PULSE applicants an opportunity to receive information on e.g. the matchmaking and application process\, as well as eligibility rules. There will also be time for Q&A:s. Find out more about the SciLifeLab PULSE postdoc program here \n\n\n\n\n\n\n\n\n\n\n\nWebinar registration\n\n\n\n\n\nWebinar on January 23\, 2025\, at 10:00 am\, UTC+1 \n\n\n\n\n\nRegister here\n\n\n\n\n\n\n\nWebinar on January 23\, 2025\, at 16:00 pm\, UTC+1 \n\n\n\n\n\nRegister here URL:https://www.scilifelab.se/event/scilifelab-pulse-information-webinars-for-applicants/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2024/12/AdobeStock_519582269-scaled-1.jpeg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20241211T083000 DTEND;TZID=Europe/Stockholm:20241211T153000 DTSTAMP:20260404T065451 CREATED:20241024T060207Z LAST-MODIFIED:20241121T102250Z UID:10001386-1733905800-1733931000@www.scilifelab.se SUMMARY:SciLifeLab & AAAS/Science Publishing Workshop for Junior Researchers 2024 DESCRIPTION:Applications are now welcome for participation in this highly regarded and rewarding interactive workshop by Science and SciLifeLab. Designed for early career researchers (PhD students and postdocs) in SciLifeLab:s research community\, the workshop focuses on the publishing landscape\, paper preparation\, and the publication process. \n\n\n\n\n\n\n\nWorkshop leaders: \n\n\n\n\nValda Vinson (Executive Editor\, Science Magazine)\n\n\n\nSacha Vignieri (Deputy Editor Research\, Science Magazine)\n\n\n\n\nThe workshop is split into a hybrid morning session\, and an afternoon on-site workshop (see Curriculum for details). Questions from the participants will be addressed by the Editors in generous Q&A sessions.  \n\n\n\nOn-site participation\, including lunch and coffee breaks with the Editors\, is limited to 40 participants. Participants for the on-site workshop will be selected after the application deadline\, with consideration for gender balance\, affilitation (with aim to distribute workshop spots nationally and across all universities)\, and in case of equivalent applications\, date of application (first come\, first serve basis). \n\n\n\nDeadline for application: November 27 \n\n\n\nApply here URL:https://www.scilifelab.se/event/scilifelab-aaas-science-publishing-workshop-for-junior-researchers-2024/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240912T090000 DTEND;TZID=Europe/Stockholm:20240912T170000 DTSTAMP:20260404T065451 CREATED:20240529T094337Z LAST-MODIFIED:20240912T065628Z UID:10001266-1726131600-1726160400@www.scilifelab.se SUMMARY:SciLifeLab Campus Solna Science Talks 2024 DESCRIPTION:We would like to warmly welcome you to take part in this year’s Campus Solna Science Talks symposium on September 12th – a meeting for everyone in the community to learn more about ongoing research and activities at SciLifeLab’s Campus Solna\, which aims to bring the community together\, inspire exchange and new collaborations. \n\n\n\nregister today\n\n\n\nResearch presentations will be given by group leaders and junior researchers (selected with consideration for balance in topics\, presenters’ career stages\, and affiliations) as part of four plenary sessions that will be mixed with poster sessions\, panel discussions and a few surprises. \n\n\n\nWe invite all Campus Solna research groups to be represented with at least 1 poster (and maximum 3). Furthermore\, we want to encourage all infrastructure units\, support functions (IT\, OO\, Site support) and committees (DEI\, Public Engagement\, CSI and the PhD&Postdoc Council) to partake with posters! \n\n\n\nProgram\n08:30Arrival\, registration and coffeeLife City\, Solnavägen 3H09:00Welcome and opening of symposiumPer Ljungdahl and Jan Ellenberg09.15Session 1: Immunology in health and diseaseChair: Adnane Achour09.20Using a cell-type centric approach for vascular disease risk profilingLynn Butler 09.35Characterization of NK cell receptor orchestration at the immunological synapsePatrick Ross09.50Towards computationally-optimised immunotherapyLuca Panconi10.05Session wrap-up10:10Coffee\, Speakers’ corner & Poster session10:50Session 2: Tackling cancer: From omics data over system models to drug designChair: María Bueno Alvez10.55Spatial VDJ and immune response in cancer Kim Thrane11.10Deep learning models of cancer mechanismsAvlant Nilsson11.25Protein structure prediction\, interactions\, and universal binder designPatrick Bryant11.40Session wrap-up11.45Leg stretch11:50Panel discussion: Science beyond impact factorModerators: Niclas Jareborg & Isolde PalomboPanelists: Annika Jenmalm Jensen\, Ylva Engström\, Andrea Fossati\, Anniina Vihervaara12:20Lunch\, Speakers’ corner & Poster session13.40Session 3: Environmental impacts on molecular systemsChair: Bénilde Bonnefille13.45Metabolic versatility and switch mechanisms of sulfur bacteria in oxygen minimum zones of Baltic Sea\, Saravana Kumar14.00Epigenetic Transgenerational Effects of Environmental Pollution: Assessing the Impact of the Herbicide Linuron on Xenopus tropicalis FrogsMauricio Roza14.15Chemical Exposomics in a Longitudinal Swedish Wellness Cohort (S3WP)Kalliroi Sdougkou14.30Session wrap-up14.35Coffee\, Speakers’ corner & Poster session15.05Session 4: Mining\, molecular profiling and analysesChair: Olena Berkovska15:10Charting the human immune landscape across development and diseaseBurcu Ayoğlu15.25Mining for novel microproteins involved in tumor epithelial-mesenchymal balanceAlberto M. Arenas Molina15.40A human pan-disease blood atlas based on next generation blood profilingMaria Bueno Alvez15.55Session wrap-up16.00Leg stretch and poster demounting16.10Panel discussion: Campus Solna future Directions and Collaborative Opportunities Moderators: Iskra Pollak Dorocic & Per LjungdahlPanelists: Claudia Fredolini\, Jessica Lindvall\, Patrick Bryant\, Eva Brinkman\, Carsten Daub16.45Concluding remarksPer Ljungdahl17.00Pub at Campus Solna\n\n\n\n\nPosters\nEach group/unit is welcome to bring up to 3 posters to the grand Poster Session that will follow the talks. Submit the poster titles in the registration form. Please coordinate within your research group/unit beforehand who should bring a poster. \n\n\n\nPlease add your building and floor to the poster\, so that everyone knows where your research is taking place. \n\n\n\nPoster size; A0 or smaller \n\n\n\nPoster list Science Talks 2024Download\n\n\n\n\nBreak activities\nRoomOrganiserDescriptionFutureCoaching in Science InitiativeRelax and Recharge – Guided Meditation Sessions with the Coaching in Science InitiativeWarmly welcome to visit the Coaching in Science Initiative (CSI). Here\, we will provide a break and an opportunity to relax. Join us for a guided meditation\, body scan with nature sounds\, and other relaxation techniques. In the future\, we are exploring arranging weekly such events at SciLifeLab in Solna.CreativePhD and postdoc council at Campus SolnaFrom SciLifeLab for SciLifeLabMeet and discuss with the members of the PhD and postdoc council about ongoing initiatives\, challenges at Campus Solna and your ideas for a better community!EvolutionSciLifeLab Events and CommunicationShowcasing the Beauty of Science – Art at Campus SolnaAt SciLifeLab’s Solna campus\, we’re discovering that science and art aren’t as different as they might seem. Our researchers\, who are dedicated to advancing knowledge\, often create stunning visual art through their scientific work. These images\, rooted in research\, showcase the inherent beauty in scientific discovery\n\n\n\n\nScientific Committee\nThis event has been made possible through the hard work of the Scientific committee. \n\n\n\nScientific Committee \n\n\n\n\nAdnane Achour\n\n\n\nMarcel Tarbier\n\n\n\nIskra Pollack Dorocic\n\n\n\nHaris Babacic\n\n\n\nPer Ljungdahl\n\n\n\n\nOperations Office representatives \n\n\n\n\nIsolde Palombo\n\n\n\nDisa Larsson Hammarlöf URL:https://www.scilifelab.se/event/scilifelab-campus-solna-science-talks-2024/ LOCATION:Life City\, Solnavägen 3H\, Stockholm\, 113 64 CATEGORIES:Community ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240910T151500 DTEND;TZID=Europe/Stockholm:20240910T160000 DTSTAMP:20260404T065451 CREATED:20240902T072833Z LAST-MODIFIED:20240902T074501Z UID:10001343-1725981300-1725984000@www.scilifelab.se SUMMARY:[Spotlight seminar] - Designing brighter dyes for advanced fluorescence microscopy and beyond DESCRIPTION:Dr. Luke D. Lavis\, Howard Hughes Medical Institute\, USA  \n\n\n\nBiography\n\n\n\n Luke D. Lavis received his B.S. in Chemistry from Oregon State University in 2000 and his Ph.D. in Organic Chemistry from the University of Wisconsin–Madison in 2008. Circumventing a traditional postdoc\, he than began his independent career as a Group Leader at the Howard Hughes Medical Institute’s Janelia Research Campus\, and was promoted to Senior Group Leader and Head of Molecular Tools and Imaging in 2017. His research focuses on designing small-molecule tools for imaging\, leading to the development of the widely used Janelia Fluor® dyes and the founding of Eikon Therapeutics in 2019. \n\n\n\nAbstract\n\n\n\nSpecific labeling of biomolecules with bright\, photostable fluorophores is the keystone of fluorescence microscopy. An established method to label cellular components utilizes genetically encoded self-labeling tags\, which enable the attachment of chemical fluorophores to specific proteins inside living cells. For the last decade\, our laboratory has focused on the development of improved fluorophores for use in living systems. We discovered a simple structural modification to classic fluorophores—incorporation of a four-membered azetidine ring—that substantially improves quantum efficiency and photostability. This strategy is generalizable to fluorophores from different structural classes and has yielded a palette of optimized chemical dyes for use in advanced microscopy experiments ranging from single-molecule tracking in individual cells to population voltage imaging in vivo. \n\n\n\nHost: Simon Elsässer\, KI\, simon.elsasser@scilifelab.se URL:https://www.scilifelab.se/event/spotlight-seminar-designing-brighter-dyes-for-advanced-fluorescence-microscopy-and-beyond/ LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240619T090000 DTEND;TZID=Europe/Stockholm:20240619T120000 DTSTAMP:20260404T065451 CREATED:20240614T151702Z LAST-MODIFIED:20240614T151815Z UID:10001276-1718787600-1718798400@www.scilifelab.se SUMMARY:Uppsala University DDLS Fellows - public seminars with candidates DESCRIPTION:Evolution and Biodiversity in the light of massive data details\n\n\n\nMeeting details\n\n\n\nWednesday\, June 19\, 2024 9:00-12:00 \n\n\n\nLocation: Lindahl-hall\, EBC Uppsala University. The meeting will also be on Zoom. Join us on: Zoom link >>   \n\n\n\nPasscode: DDLS \n\n\n\nSchedule\n\n\n\n9.00-9.15 Welcome9.15-9.45 Jennifer James: Investigating proteome trends: Evolution over huge timescales10.00-10.30 Julia V. Tavares: Forest sensitivity and resilience to climatic and hydrological changes10.45-11.15 Laura Antao: Elucidating biodiversity change in the Anthropocene11.30-12.00 Darrin Schultz: Chromosome structure as an evolutionary ledger URL:https://www.scilifelab.se/event/uppsala-university-ddls-fellows-public-seminars-with-candidates-evolution-and-biodiversity-in-the-light-of-massive-data/ CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240618T080000 DTEND;TZID=Europe/Stockholm:20240619T170000 DTSTAMP:20260404T065451 CREATED:20231020T081018Z LAST-MODIFIED:20240618T044504Z UID:10001007-1718697600-1718816400@www.scilifelab.se SUMMARY:Facility Forum 2024 DESCRIPTION:Dear SciLifeLab Infrastructure Team\, \n\n\n\nWe have finally arrived! It’s time for the SciLifeLab Facility Forum 2024. We look forward to your participation in this engaging and informative experience on June 18-19\, 2024\, at the Clarion Sign Hotel in central Stockholm.This year\, the event will bring together 442 participants\, continuing the growth from the first Facility Forum in Uppsala in 2017 with 253 participants\, 338 in Djurönäset in 2019\, and 376 for the last meeting in Djurönäset in 2022. The primary objectives of the meeting are to promote cross-facility collaborations\, increase community feeling among platform and facility personnel\, discuss specific infrastructure issues\, foster competence development\, and provide ample time for discussion and exchange.One highlight of the event will be a session with the current and new SciLifeLab directors\, where they will share and discuss their visions for the future of Life Science and SciLifeLab. Additionally\, the program includes various sessions and workshops aimed at enhancing collaboration and professional growth.We are excited to have you join us! Below\, you can find all the important information you need to know to make your participation easier. \n\n\n\nAnnika Jenmalm Jensen\, Infrastructure Director SciLifeLabLars Johansson\, Infrastructure Coordinator SciLifeLab \n\n\n\n \n\n\n\n\n\n\n\n \n\n\n\nMeet the speakers\n\n\n\n\n\n\n\n\n\nDr. Kelly Vere\, MBE\, is Director of Technical Strategy at the University of Nottingham\, UK. She is a passionate advocate for technical skills\, roles and careers and has created\, facilitated and led a number of opportunities for the technical community\, including the new UK Institute for Technical Skills & Strategy and the Technician Commitment initiative. \n\n\n\nKeynote \n\n\n\nA path for everyone: creating sustainable scientific careers \n\n\n\nFrom the shadows to the spotlight: the UK’s approach to elevating technical contributions to research and innovation \n\n\n\n\n\n\n\n\n\nAlessio Ciulli is Professor of Chemical and Structural Biology and Director of the Centre for Targeted Protein Degradation\, University of Dundee\, UK. At Facility Forum\, he will present a keynote about the importance of self-leadership\, engagement\, and inclusion to build a successful team. \n\n\n\nKeynote \n\n\n\nTeam building\, leadership\, inclusion and good competition \n\n\n\nThe importance of self-leadership\, engagement\, and inclusion to build a successful team. \n\n\n\n\n\n\n\n\n\nProgram\n\n\n\n \n\n\n\nFF-ProgramDownload\n\n\n\nPractical information\n\n\n\nA Blossoming Banquet \n\n\n\nA grand banquet will take place on the evening of June 18. The theme for the dinner will be a floral celebration – so wear your flowery dress\, hat or suit! And\, your creative skills may be put to the test! \n\n\n\nThe Facility Forum Podcast \n\n\n\nContribute and make your voice heard in the Facility Forum Podcast. Submit your wish to join here.  Kindly include a few lines about your role and a story you would like to highlight. \n\n\n\n \n\n\n\nBus transfer from/to Uppsala \n\n\n\nSciLifeLab will provide direct bus transfer from Uppsala (BMC) to the venue\, and back. The bus departs from Uppsala BMC\, June 18\, 07:45\, and from Clarion Sign at 15:30 on Wednesday\, June 19. \n\n\n\nCloakroom & Registration \n\n\n\nLeave your luggage in the cloakroom\, staffed from 09 to 17 on Tuesday and from 08 to 16 on Wednesday. We can not accept luggage other than small handbags and regular (e.g.\, laptop) backpacks in the Big Hall. \n\n\n\nRegistration opens at 09:00 at the Clarion Sign; the registration area is next to the Conference entrance. Register by showing the QR code that will be emailed to you shortly before the Conference. The nametags are sorted by Last name. \n\n\n\nHotel check-in/out \n\n\n\nCheck-in: The room will be available from 16:00. Rooms at Clarion Sign are available outside the lecture all after the end of the day’s sessions. \n\n\n\nAbout 100 participants are staying at Clarion Hotel Amaranten\, 10 minute walk from Clarion Sign. You will find your keycard at Amaranten. \n\n\n\nCheck-out: Leave the key card by the Hotel reception desk after breakfast. Put your luggage in the cloakroom. To facilitate check-out\, you cannot put anything on the room bill\, such as snacks and drinks or a bar tab. \n\n\n\n \n\n\n\nWorkshops\n\n\n\nThere will be three rounds of workshops\, with two taking place on both Tuesday and Wednesay. The Session “Hands-on with Large Language Models” is part of the plenary program. Workshop instructions has been sent out in advance. \n\n\n\n\n\n\n\nList of workshopsDownload URL:https://www.scilifelab.se/event/facility-forum-2024/ LOCATION:Clarion Sign Hotel\, Östra Järnvägsgatan 35\, Stockholm\, Stockholm\, 111 20\, Sweden CATEGORIES:Community ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2023/10/Facility-Forum-Square.png ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240617T130000 DTEND;TZID=Europe/Stockholm:20240617T140000 DTSTAMP:20260404T065451 CREATED:20240508T124016Z LAST-MODIFIED:20240516T084026Z UID:10001258-1718629200-1718632800@www.scilifelab.se SUMMARY:How protein degraders work: Molecular mechanism and drug design DESCRIPTION:Alessio Ciulli \n\n\n\n\n\n\n\nProfessor of Chemical Structural Biology \n\n\n\nFounder and Director\, Centre for Targeted Protein Degradation \n\n\n\nSchool of Life Sciences\, University of Dundee \n\n\n\nAbstract\n\n\n\nProtein degraders (also known as PROTACs and molecular glues) are a new class of small molecule tools and drugs that trigger the rapid depletion of a target protein inside the cell. Degraders work via forming a ternary complex\, bridging a target protein to a ubiquitin E3 ligase. This allows the E3 ligase to label the target protein with ubiquitin molecules\, leading to the protein being recognized and degraded by the proteasome. Whereas conventional drugs only inhibit disease-causing proteins by binding and locking up their most important functional parts for the duration of the drug’s action\, degraders can bind at any positions and cause the protein rapid and long-lasting destruction. This lecture will recount some of our fundamental discoveries and insights that have helped to advance understanding and illuminate the molecular mechanism of how degraders work. It will illustrate how such fundamental principles have been applied to design high-quality degraders against challenging drug targets\, and will highlight some of the latest progress from the laboratory. \n\n\n\nBiography\n\n\n\nAlessio Ciulli studied chemistry in Florence\, Italy\, and obtained his PhD from the University of Cambridge\, UK\, in 2006. After postdoctoral research in Cambridge and a brief visit at Yale University in the USA\, he returned to Cambridge in 2009 to start his independent laboratory. In 2013\, he moved to the University of Dundee\, UK\, where he was promoted to full professor in 2016. He has received numerous prizes and awards for his discoveries\, most recently the 2022 Prous Institute – Overton and Meyer Award for New Technologies in Drug Discovery from the European Federation of Medicinal Chemistry (EFMC). In 2023 he was elected Fellow of the Royal Society of Edinburgh. He is the scientific founder of Amphista therapeutics\, a targeted protein degradation company spin out of his laboratory\, and the founder and director of the University of Dundee’s new Centre for Targeted Protein Degradation which opened in January 2023. The Ciulli Laboratory focuses on chemical biology and structural biology to develop small molecules inducing targeted protein degradation and modulating protein-protein interactions and translates their fundamental research via collaboration partnership with the biopharma industry and by creation of spin-out companies. URL:https://www.scilifelab.se/event/how-protein-degraders-work-molecular-mechanism-and-drug-design/ LOCATION:Petrén Hall\, Nobels väg 12B\, Solna\, 17121\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240521T103000 DTEND;TZID=Europe/Stockholm:20240521T120000 DTSTAMP:20260404T065451 CREATED:20240515T074909Z LAST-MODIFIED:20240515T074909Z UID:10001259-1716287400-1716292800@www.scilifelab.se SUMMARY:Uppsala University DDLS Fellows - public seminars with candidates - part II DESCRIPTION:Welcome to the second data driven-rich morning of scientific presentations by 2 candidates for the DDLS program fellow position on Data-driven Precision Medicine and Diagnostics and Biträdande Universitets Lektor position at Uppsala University. \n\n\n\nSchedule \n\n\n\nMeeting details\n\n\n\nTuesday\, May 21\, 2024 10:30-12:00 \n\n\n\nZoom link >>   \n\n\n\nMötes-ID: 663 2681 5420 \n\n\n\nSchedule\n\n\n\n10:30-11:05     \n\n\n\nMarcel Tarbier\, Karolinska Institutet\, Stockholm\, Sweden \n\n\n\nInto the Single-Verse: Inferring complex gene and cell features from gene expression – and an excursion through space and time \n\n\n\n11:05-11:40      \n\n\n\nMuhammad Arif\, National Institute on Alcohol Abuse and Alcoholism\, Rockville\, USA \n\n\n\nIntegrative Multi-Omics Frameworks for Understanding the Molecular Mechanism of Progressive Diseases URL:https://www.scilifelab.se/event/uppsala-university-ddls-fellows-public-seminars-with-candidates-part-ii/ CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240516T141500 DTEND;TZID=Europe/Stockholm:20240516T163500 DTSTAMP:20260404T065451 CREATED:20240429T090516Z LAST-MODIFIED:20240429T091240Z UID:10001246-1715868900-1715877300@www.scilifelab.se SUMMARY:Uppsala University DDLS Fellows - public seminars with candidates DESCRIPTION:Welcome to a data driven-rich afternoon of scientific presentations by 4 candidates for the DDLS program fellow position on Data-driven Precision Medicine and Diagnostics and Biträdande Universitets Lektor position at Uppsala University. \n\n\n\nMeeting details\n\n\n\nMonday\, May 6\, 2024 14:15-16:35 \n\n\n\nZoom link >>   \n\n\n\nMötes-ID: 640 7985 9903 \n\n\n\nSchedule\n\n\n\n14:15-14:50     \n\n\n\nSergi Sayols Baixeras\, Uppsala University\, Dep. of Medical Sciences\, Sweden \n\n\n\nNovel Insights fromZMetagenomics and Metabolomics on Atherosclerotic Disease \n\n\n\n14:50-15:25      \n\n\n\nQiaoli Wang\, Harvard University Medical School\, Cambridge\, USA \n\n\n\nAnticipatory Detection of Upper-Gastrointestinal Cancers: Staying One Step Ahead with a Dash of Wit \n\n\n\n15:25-16:00      \n\n\n\nMuhammad Arif\, National Institute on Alcohol Abuse and Alcoholism\, Rockville\, USA \n\n\n\nIntegrative Multi-Omics Frameworks for Understanding the Molecular Mechanism of Progressive Diseases \n\n\n\n16:00-16:35      \n\n\n\nFilipe Barata\, Centre for Digital Health Interventions\, ETH Zurich\, Switzerland & Stanford University\, Palo Alto\, USA.  \n\n\n\nAdvancing Personalized Healthcare Through Digital Biomarkers URL:https://www.scilifelab.se/event/uppsala-university-ddls-fellows-public-seminars-with-candidates/ CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20231031T130000 DTEND;TZID=Europe/Stockholm:20231031T160000 DTSTAMP:20260404T065451 CREATED:20231010T074915Z LAST-MODIFIED:20231020T074900Z UID:10000996-1698757200-1698768000@www.scilifelab.se SUMMARY:I Forskningens Framkant - Fortbildning för Gymnasielärare DESCRIPTION:Välkommen till en fortbildning där du får uppleva delar av det nationella forskningscentret för molekylära biovetenskaper i Stockholm. \n\n\n\nDenna eftermiddag får du möta fyra forskare som berättar om sin forskning och så gör vi en rundvandring på SciLifelab. Fortbildningen avslutas med mingel med tilltugg. \n\n\n\nProgram12:30-13:00 Kaffe13:00-14:30 Föreläsningar – fyra forskare från SciLifeLab14:30-15:00 Visning av labb15:00-16:00 Mingel med tilltugg \n\n\n\nPlats: SciLifeLab\, Tomtebodavägen 23\, SolnaKarta: Google Maps \n\n\n\nVälkommen med din anmälan! \n\n\n\nRegistrering\n\n\n\nFrom Genes to Proteins: The Power of the Human Protein AtlasFredrik Edfors\, SciLifeLab/KTHFramtidens målsökande läkemedelStefan Ståhl\, SciLifeLab/KTHKlinisk GenomikAnna Lyander\, SciLifeLab/Karolinska InstitutetMikrobernas samhällenAnders Andersson\, SciLifeLab/KTH14:00-15:00 Rundvandring i lokalerna15:00-16:00 Mingel med tilltugg \n\n\n\n \n\n\n\nFrom Genes to Proteins: The Power of the Human Protein AtlasFredrik Edfors\, SciLifeLab/KTH \n\n\n\nHuman Protein Atlas (HPA) som finansieras av Knut och Alice Wallenbergs stiftelse är ett svenskt projekt som är baserat på SciLifeLab\, en nationell samarbetsplattform för molekylär biologi som drivs av KTH\, Karolinska Institutet\, Stockholms universitet och Uppsala universitet. Människan har cirka 20 000 gener som kodar för proteiner\, och HPA hjälper till att identifiera olika kombinationer av proteiner som är avgörande för mänsklig biologi. HPA strävar efter att systematiskt kartlägga det mänskliga genomet på proteinnivå och på www.proteinatlas.org presenteras dessa nivåer inom flera olika fokusområden. Dessa inkluderar bland annat inkluderar proteinuttryck i vävnader\, hjärna\, cell-linjer eller nivåer blod och hur dessa skiljer sig mellan olika sjukdomstillstånd. Förutom att stödja andra forskare är atlasen också en värdefull utbildningsresurs för ämnen som rör den mänskliga kroppen\, cellbiologi och molekylärbiologi.  \n\n\n\nFramtidens målsökande läkemedelStefan Ståhl\, SciLifeLab/KTH \n\n\n\nSmå bindarproteiner kan med hjälp av riktad evolution fås att binda till sjukdomsrelaterade proteiner\, så kallade biomarkörer\, som kan utnyttjas som måltavlor för nya typer av proteinläkemedel. Som exempel kan cancertumörceller målsökas på detta sätt. Dessa målsökande bindarproteinerna kan “beväpnas”\, t.ex. med cellgifter eller lämpliga radioisotoper som dödar tumörcellerna\, med minimal påverkan på frisk vävnad. \n\n\n\nKlinisk GenomikAnna Lyander\, SciLifeLab/Karolinska Institutet \n\n\n\nClinical Genomics är en infrastrukturplattform vid Scilifelab. Plattformen arbetar med avancerade genomikmetoder\, olika typer av sekvenseringsteknologier och dataanalysverktyg\, för att stötta forskning och sjukvård. Clinical Genomics erbjuder en helhetslösning inom next generation sequencing för translationella forskningsprojekt och kliniska studier\, och bidrar till att optimera tekniker så att de kan användas inom precisionsmedicin. Plattformen arbetar också inom ramen för Genomic Medicine Sweden för att harmonisera precisionsmedicin i Sverige vilket banar väg för bättre diagnostik\, vård och behandling i hela landet. \n\n\n\nMikrobernas samhällenAnders Andersson\, SciLifeLab/KTH URL:https://www.scilifelab.se/event/i-forskningens-framkant-fortbildning-for-gymnasielarare/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20231024T090000 DTEND;TZID=Europe/Stockholm:20231024T190000 DTSTAMP:20260404T065451 CREATED:20231018T073920Z LAST-MODIFIED:20231024T071000Z UID:10001002-1698138000-1698174000@www.scilifelab.se SUMMARY:SciLifeLab Campus Solna Science Talks DESCRIPTION:We would hereby like to warmly welcome you to take part in this year’s Campus Solna Science Talks symposium on October 24th – a meeting for everyone in the community to learn more about ongoing research and activities at SciLifeLab’s Campus Solna\, which aims to bring the community together\, inspire exchange and new collaborations. \n\n\n\nResearch presentations will be given by group leaders and junior researchers (selected with consideration for balance in topics\, presenters’ career stages\, and affiliations) as part of a plenary session between 9:00 and 16:00 (including lunch)\, and the event will conclude with a poster session\, mingle and food in Campus Solna’s meeting place Delta. \n\n\n\nWe invite all Campus Solna research groups to be represented with at least 1 poster (and maximum 3). Furthermore\, we want to encourage all infrastructure units and committees (The Diversity\, Equity and Inclusion-committee\, the Public Engagement-committee\, the CSI and the PhD- & Postdoc-council) to partake with posters! \n\n\n\nList of Posters (titles & numbering) \n\n\n\n\n\n\n\n \n\n\n\n\n\n\n\nProgram\n08:30Arrival\, registration and coffeeJacob Berzelius hall\, Karolinska Institutet09:00Welcome and opening of symposiumScientific Committee & Per LjungdahlSession I. Moderator Yerma Pareja09:15Mapping B and T cell receptors using spatial transcriptomicsCamilla Engblom09:30Use the Flow\, Leukocyte: ion and water fluxes are required for T cell migrationLeon de Boer09:45B cell repertoire analysis of SARS-CoV-2-infected individualsGunilla Karlsson Hedestam10:15Coffee BreakSession II. Moderator Marcel Tarbier10:45agoTRIBE detects microRNA-target interactions transcriptome-wide in single cellsVaishnovi Sekar11:00Single cell-resolution in situ sequencing elucidates spatial dynamics of multiple sclerosis lesion and disease evolutionChristoffer Mattsson Langseth11:15Beyond the host’s spatial transcriptomeStefania Giacomello11.30Machine learning of immune escape dynamics from single cell and spatial tumor transcriptomicsJakob Rosenbauer11.45LunchSession III. Moderator Ute Hoffmann13:00Female sex hormones and the human microbiomeLuisa Hugherth13:15Environmental genomics for broadscale studies on aquatic microbial diversity and evolutionKrzysztof Jurdzinski13:30Interaction proteomics to explore protein regulation in photosynthetic organismsAnna Karlsson13:45Developmental Gene TranscriptionMattias Mannervik14:15Coffee BreakSession IV. Moderator Erdinc Sezgin14:45Modelling Glut1 Deficiency Syndrome (Glut1DS) for therapeutics and drug discoveryRekha Tripathi15:00Multiplexed high-content screening of drug and immune sensitivity in microwellsValentina Carannante15:15Dynamics at the molecular scale from cells to STARSSIlaria Testa15:45Concluding RemarksPer Ljungdahl16:00Poster SessionSciLifeLab DeltaMingle\, pub and light food\n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\n\nPoster Session\nEach group/unit is welcome to bring up to 3 posters to the grand Poster Session that will follow the talks. Submit the poster titles in the registration form. Please coordinate within your research group/unit beforehand who should bring a poster. Poster session will take place in the Delta building in SciLifeLab Solna. \n\n\n\nPoster dimensions: 70×100 \n\n\n\n \n\n\n\n\n\n\n\n\nScientific Committee\nThis event has been made possible through the hard work of the Scientific committee. \n\n\n\nScientific Committee \n\n\n\n\nErdinc Sezgin\n\n\n\nMarcel Tarbier\n\n\n\nUte Hoffman\n\n\n\nStefania Giacomello\n\n\n\nKristoffer Sahlin\n\n\n\nPer Ljungdahl\n\n\n\n\nOperations Office representatives \n\n\n\n\nIsolde Palombo\n\n\n\nDisa Larsson Hammarlöf URL:https://www.scilifelab.se/event/scilifelab-campus-solna-science-talks-2/ LOCATION:Jacob Berzelius salen\, KI\, Berzelius väg 3\, Solna\, 171 65\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/07/181A6885-Danish-Saroee_frikopt-scaled.jpg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230901T085000 DTEND;TZID=Europe/Stockholm:20230901T092500 DTSTAMP:20260404T065451 CREATED:20230822T125503Z LAST-MODIFIED:20230829T115842Z UID:10000956-1693558200-1693560300@www.scilifelab.se SUMMARY:Open online lecture by Prof. Edward Holmes: Metagenomics at the human-animal interface DESCRIPTION:The PLP (Pandemic Laboratory Preparedness) program\, started in 2021\, acts to meet society’s need for efficient use of resources\, training and education\, to propagate skills and setting up technologies and equipment to be better prepared for new pandemics. \n\n\n\nDuring the upcoming PLP program retreat\, on Friday September 1 at 08:50\, we are honored to welcome Professor Edward Holmes for an online lecture\, open for everyone to join. \n\n\n\n\n\n\n\n\n\nEdward (Eddie) Holmes is an evolutionary biologist distinguished for his work on the emergence and evolution of viruses. He has used genomic and phylogenetic approaches to reveal the major mechanisms of virus evolution and determined the genetic and epidemiological processes that explain how viruses jump species boundaries and spread in new hosts.His work has revealed the origin\, evolution and molecular epidemiology of important human pathogens including influenza\, HIV and dengue\, and enabled more accurate assessments of what types of virus are most likely to emerge in human populations and whether they will evolve human-to-human transmission. His recent research has provided fundamental insights into the breadth and biodiversity of the viral world.Eddie is currently a Professor in the School of Medical Sciences at the University of Sydney. In 2015 he was elected a Fellow of the Australian Academy of Science and in 2017 he was elected a Fellow of the Royal Society. In 2021 he received the Australian Prime Minister’s prize for science. \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nZoom link URL:https://www.scilifelab.se/event/open-online-lecture-by-prof-edward-holmes-metagenomics-at-the-human-animal-interface/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230607T120000 DTEND;TZID=Europe/Stockholm:20230607T124500 DTSTAMP:20260404T065451 CREATED:20230511T125240Z LAST-MODIFIED:20230529T151705Z UID:10000890-1686139200-1686141900@www.scilifelab.se SUMMARY:Knut and Alice Wallenberg Foundation and SciLifeLab Proof of Concept Grant in Life Science (lunch seminar) DESCRIPTION:Lunch seminar (also available through Streamo) where a new call for proof-of-concept funding aiming to ignite life science innovation will be presented. \n\n\n\nRegister\n\n\n\nAre you financed through Knut and Alice Wallenberg Foundation\, a SciLifeLab researcher or infrastructure staff with ideas for commercialization\, this seminar is for you. \n\n\n\nLunch sandwiches will be served for participants attending in person. Register now on the link below. \n\n\n\nThe purpose of the Proof of Concept grant is to bridge the gap from academic research to innovations in life science. The grant gives researchers the opportunity to develop their early-stage discoveries towards validated methods\, products or processes and  provides the opportunity to carry out activities that validate and accelerate the development of the project and prepare for innovation and commercialization. \n\n\n\nThe Proof of Concept grant is not meant as a translational academic research grant\, but as a specific goal-oriented project to develop an academic discovery towards an innovation and a product. Hence\, translational research without a clear product-oriented thinking or a defined goal at the end of the two year period is not something that can be supported. The Proof of Concept grant is tied to the Wallenberg Launch Pad (WALP) mechanism (see below) that provides support for academic scientists to develop innovations that make an impact in society. \n\n\n\nThe approved funding for each project is suggested to be between 1 and 4 million SEK\, over a project period of a maximum of two years. The grant will be paid directly to the researcher’s university and the use of the grant must comply with the university’s regulations and the specific terms and conditions of the grant as stated by Knut and Alice Wallenberg Foundation (KAW). This is a yearly call.  \n\n\n\nApplication period \n\n\n\nThe application period for 2023 begins June 7. Last day of application August 17 at 13.00. \n\n\n\nRead more URL:https://www.scilifelab.se/event/save-the-date-for-lunch-seminar-on-upcoming-call-proof-of-concept-funding/ LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/05/Proof-of-Concept-scaled.jpeg ORGANIZER;CN="SciLifeLab Event":MAILTO:events@scilifelab.se END:VEVENT END:VCALENDAR