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X-WR-CALDESC:Events for SciLifeLab
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DTSTART;TZID=Europe/Stockholm:20220907T140000
DTEND;TZID=Europe/Stockholm:20220907T150000
DTSTAMP:20260404T065538
CREATED:20220826T140811Z
LAST-MODIFIED:20220829T151653Z
UID:10000654-1662559200-1662562800@www.scilifelab.se
SUMMARY:Single-cell and spatial atlases of the adult and developing human brain
DESCRIPTION:Recently\, we have generated single-cell atlases of the adult and developing human brain using a combination of single-cell RNA sequencing and spatial transcriptomics. In the adult\, we found an unexpectedly high diversity of neuronal types especially in the midbrain and hindbrain\, with conservatively more than 3000 distinct types. In the developing human brain\, we revealed highly refined trajectories of differentiation of cortical neurons. We further found that astrocytes and oligodendrocytes were regionally patterned\, and that these region-specific types persisted in the adult. These findings may provide a basis for the brain region-specific occurrence of pediatric brain tumors. \n\n\n\n– \n\n\n\nSpeaker\n\n\n\nSten LinnarssonResearch Division of Molecular Neurobiology\, Karolinska Institutet\, Stockholm\, Sweden  \n\n\n\nHuman Developmental Dell Atlas (HDCA) is the Swedish effort within the human cell atlas (HCA)\, one of the largest international scientific projects. The project aim is to create a comprehensive molecular atlas of human prenatal development at the molecular resolution using state-of-the-art multi-omic technologies such as single-cell RNA-seq\, Spatial Transcriptomics\, in situ sequencing in order to provide deeper insight into how variations and deviations contribute to health and disease. \n\n\n\nThe HDCA Seminar Series 2022 invites you to join us on a journey of early human organogenesis of several organs at the single-cell and spatial resolution. Seminars will be held at SciLifeLab Gamma building on Wednesdays at 14:00 or 15:00 and also via Zoom. After each seminar\, we will have up to 30 min round up discussions with the speaker on how you can contribute to the atlas! \n\n\n\naccess zoom meeting
URL:https://www.scilifelab.se/event/single-cell-and-spatial-atlases-of-the-adult-and-developing-human-brain/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/08/logo_hdca.png
ORGANIZER;CN="The Human Developmental Cell Atlas":MAILTO:hdca-sweden@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220511T140000
DTEND;TZID=Europe/Stockholm:20220511T153000
DTSTAMP:20260404T065538
CREATED:20220426T132422Z
LAST-MODIFIED:20220507T113616Z
UID:10000594-1652277600-1652283000@www.scilifelab.se
SUMMARY:Decoding the development of the human spinal cord by multi-omics
DESCRIPTION:Decoding the development of the human spinal cord by multi-omics \n\n\n\nXiaofei Li and Erik Sundström \n\n\n\nHDCA Seminar Series 2022 | Spinal cord \n\n\n\nThe human spinal cord has highly diverse cell types\, which are generated during development\, governed by a series of temporal and spatial events for proper spinal cord assembly and function. However\, the molecular regulation of cell fate specification in the human developing spinal cord remains largely unknown. Here\, by performing single-cell RNA sequencing\, spatial transcriptomics and in situ sequencing\, we integrate the datasets and provide a comprehensive single-cell and spatial transcriptomic atlas of the developing human spinal cord of the first trimester\, from postconceptional week 5 to 12. We observe that all major cell populations in human adult spinal cord have been specified within the first trimester with abundant cell states\, and identify the key genes associated with cell fate choices and their spatial expression. Unexpectedly\, we find that during early cell fate specification\, many human neural progenitor cells have lost their self-renewal capacity. Further the the expression of gliogensis genes is much higher in human compared to the correspondent rodents at the early stage\, suggesting earlier gliogenesis in human. Finally\, we demonstrate how to use our developmental map for molecular cues that direct sequential cellular differentiation and define cells and locations associated to both normal development and spinal cord diseases. \n\n\n\nsign up to attend\n\n\n\nPlease register also if you want to participate in the digital broadcast. The Zoom link will be sent out through the registration system.  \n\n\n\n– \n\n\n\nHuman developmental cell atlas (HDCA) is the Swedish effort within the human cell atlas (HCA)\, one of the largest international scientific projects. The project aim is to create a comprehensive molecular atlas of human prenatal development at the molecular resolution using state-of-the-art multi-omic technologies such as single-cell RNA-seq\, Spatial Transcriptomics\, in situ sequencing in order to provide deeper insight into how variations and deviations contribute to health and disease. \n\n\n\nThe HDCA Seminar Series 2022 invites you to join us on a journey of early human organogenesis of several organs at the single-cell and spatial resolution. Seminars will be held at SciLifeLab Gamma building on Wednesdays at 14:00 or 15:00 and also via Zoom. After each seminar\, we will have up to 30 min round up discussions with the speaker on how you can contribute to the atlas! \n\n\n\nWarm Welcome!
URL:https://www.scilifelab.se/event/decoding-the-development-of-the-human-spinal-cord-by-multi-omics/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/hdca_logo.png
ORGANIZER;CN="The Human Developmental Cell Atlas":MAILTO:hdca-sweden@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220427T140000
DTEND;TZID=Europe/Stockholm:20220427T153000
DTSTAMP:20260404T065538
CREATED:20220420T102001Z
LAST-MODIFIED:20220420T102506Z
UID:10000584-1651068000-1651073400@www.scilifelab.se
SUMMARY:Developmental origins of cell heterogeneity in the human lung
DESCRIPTION:HDCA Seminar Series 2022 | Lung \nChristo Samakovlis and Alexandros Sountoulidis \nThe lung contains numerous specialized cell-types with distinct roles in tissue function and integrity. To clarify the origins and mechanisms generating cell heterogeneity\, we created a first comprehensive topographic atlas of early human lung development. We report 83 cell states\, several spatially-resolved developmental trajectories and predict cell interactions within defined tissue niches. We integrated scRNA-Seq and spatial transcriptomics into a web-based\, open platform for interactive exploration. To illustrate the utility of our approach we show distinct states of secretory and neuroendocrine cells\, largely overlapping with the programs activated either during lung fibrosis or small cell lung cancer progression. We define the origin of uncharacterized airway fibroblasts associated with airway smooth muscle in bronchovascular bundles\, and describe a trajectory of Schwann cell progenitors to intrinsic parasympathetic neurons controlling bronchoconstriction. Our atlas provides a rich resource for further research and a reference for defining deviations from homeostatic and repair mechanisms leading to pulmonary diseases. \n  \n– \nHuman developmental cell atlas (HDCA) is the Swedish effort within the human cell atlas (HCA)\, one of the largest international scientific projects. The project aim is to create a comprehensive molecular atlas of human prenatal development at the molecular resolution using state-of-the-art multi-omic technologies such as single-cell RNA-seq\, Spatial Transcriptomics\, in situ sequencing in order to provide deeper insight into how variations and deviations contribute to health and disease. \nThe HDCA Seminar Series 2022 invites you to join us on a journey of early human organogenesis of several organs at the single-cell and spatial resolution. Seminars will be held at SciLifeLab Gamma building on Wednesdays at 14:00 or 15:00 and also via Zoom. After each seminar\, we will have up to 30 min round up discussions with the speaker on how you can contribute to the atlas!  \nWarm Welcome! \n  \n\n\nregistration
URL:https://www.scilifelab.se/event/developmental-origins-of-cell-heterogeneity-in-the-human-lung/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/logo_hdca2.png
ORGANIZER;CN="The Human Developmental Cell Atlas":MAILTO:hdca-sweden@scilifelab.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220302T140000
DTEND;TZID=Europe/Stockholm:20220302T153000
DTSTAMP:20260404T065538
CREATED:20220224T150156Z
LAST-MODIFIED:20220302T091116Z
UID:10000538-1646229600-1646235000@www.scilifelab.se
SUMMARY:TissUUmaps 3: Interactive visualization and quality assessment of large-scale spatial omics
DESCRIPTION:HDCA Seminar Series 2022 | TissUUmaps \n\n\n\nSpeakers: \n\n\n\nCarolina Wählby and Christophe Avenel \n\n\n\nWe present TissUUmaps\, browser-based tool for GPU-accelerated visualization and interactive exploration of tens of millions of datapoints overlaying tissue samples. Users can visualize markers and regions\, explore spatial statistics and quantitative analyses of tissue morphology\, and assess the quality of decoding in situ transcriptomics data. TissUUmaps provides instant multi-resolution image viewing\, can be customized\, shared\, and also integrated in Jupyter Notebooks. It is also possible to directly connect spatial markers with markers in feature space\, such as UMAP plots\, to interactively relate feature space with physical space. We envision TissUUmaps to contribute to broader dissemination and flexible sharing of large-scale spatial omics data\, and it is already being used for sharing of data from the Human Developmental Lung Cell Atlas\, as shared via the TissUUmaps gallery: https://tissuumaps.github.io/gallery/. \n\n\n\nRegistration\n\n\n\n– \n\n\n\nHuman developmental cell atlas (HDCA) is the Swedish effort within the human cell atlas (HCA)\, one of the largest international scientific projects. The project aim is to create a comprehensive molecular atlas of human prenatal development at the molecular resolution using state-of-the-art multi-omic technologies such as single-cell RNA-seq\, Spatial Transcriptomics\, in situ sequencing in order to provide deeper insight into how variations and deviations contribute to health and disease. \n\n\n\nThe HDCA Seminar Series 2022 invites you to join us on a journey of early human organogenesis of several organs at the single-cell and spatial resolution. Seminars will be held at SciLifeLab Gamma building on Wednesdays at 14:00 or 15:00 and also via Zoom. After each seminar\, we will have up to 30 min round up discussions with the speaker on how you can contribute to the atlas!  \n\n\n\nWarm Welcome!
URL:https://www.scilifelab.se/event/tissuumaps-3-interactive-visualization-and-quality-assessment-of-large-scale-spatial-omics/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/logo_hdca2-1.png
ORGANIZER;CN="The Human Developmental Cell Atlas":MAILTO:hdca-sweden@scilifelab.se
END:VEVENT
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