BEGIN:VCALENDAR VERSION:2.0 PRODID:-//SciLifeLab - ECPv6.15.20//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:https://www.scilifelab.se X-WR-CALDESC:Events for SciLifeLab REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20220327T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20221030T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20230326T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20231029T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20250330T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20251026T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20260329T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20261025T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20270328T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20271031T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260323T151500 DTEND;TZID=Europe/Stockholm:20260323T161500 DTSTAMP:20260511T004504 CREATED:20260310T152728Z LAST-MODIFIED:20260310T152729Z UID:10001771-1774278900-1774282500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Defining Zika virus disease in maternal-fetal infection DESCRIPTION:Jenny Go \n\n\n\n Assistant Professor in the Department of Microbiology and Immunology at the University of Minnesota\, USA \n\n\n\nBio\n\n\n\nDr. Go is an Assistant Professor in the Department of Microbiology and Immunology at the University of Minnesota where her research program is focused on understanding innate immune and inflammatory responses in the control of viral infection. She was awarded a PhD from the Department of Microbiology and Immunology at the University of Illinois at Chicago where she studied enveloped viral glycoproteins of SARS-CoV and avian H5N1 influenza virus. She completed postdoctoral training at the University of Washington in the Microbiology Department pursuing a systems biology approach to study virus-host interactions and the application of omics technologies toward infectious disease research. \n\n\n\nDefining Zika virus disease in maternal-fetal infection\n\n\n\nZika virus (ZIKV) is a mosquito-borne neuroinvasive virus that was responsible for the 2015-2016 large-scale epidemic impacting over 80 countries globally. It remains a significant public health threat due to its capacity to trigger widespread\, multifactorial outbreaks and severe fetal health outcomes\, including neurologic malformations at birth. We have used a macaque model of maternal-fetal ZIKV transmission to study virus-host interactions that underlie fetal disease and found that prenatal ZIKV exposure led to disruption of fetal myelin\, with extensive downregulation in gene expression for key components of oligodendrocyte maturation and myelin production. The molecular features of ZIKV-induced brain injury were evaluated in mixed neural cultures at single-cell resolution and we identified astrocytes as important innate immune cells\, while neural stem cells supported high levels of viral replication. Our findings reinforce the serious nature of ZIKV infection during pregnancy and the need for effective drugs or vaccines to prevent ZIKV congenital infection. \n\n\n\n \n\n\n\nHost: Jan Komorowski jan.komorowski@icm.uu.seUU URL:https://www.scilifelab.se/event/the-svedberg-seminar-jenny-go/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260309T151500 DTEND;TZID=Europe/Stockholm:20260309T161500 DTSTAMP:20260511T004504 CREATED:20260223T084935Z LAST-MODIFIED:20260223T084936Z UID:10001762-1773069300-1773072900@www.scilifelab.se SUMMARY:[The Svedberg seminar] - The evolution of new vertebrate cell types and organs DESCRIPTION:Margarida Cardoso-Moreira \n\n\n\nPhD Group Leader of Evolutionary Developmental Biology lab at the Francis Crick Institute\, UK \n\n\n\nBio\n\n\n\nMargarida Cardoso Moreira leads the Evolutionary Developmental Biology lab at the Francis Crick Institute in London. Her lab focuses on understanding how new cells\, tissues\, and organs originate using pregnancy as a model. Margarida did her PhD research in Manyuan Long’s group at the University of Chicago. She then took a postdoctoral position in Andrew G. Clark’s group at Cornell University. While at Chicago and Cornell\, Margarida investigated the evolution of newly duplicated genes. Margarida then joined the group of Henrik Kaessmann (University of Lausanne and Heidelberg University)\, where she spearheaded a research program on the evolution of mammalian organs\, for which she received the Otto-Schmeil prize from the Heidelberg Academy of Sciences and Humanities in 2020. \n\n\n\nThe evolution of new vertebrate cell types and organs\n\n\n\nHow do new cells\, new tissues\, and entire new organs arise during evolution? Our lab investigates these questions using an organ that has evolved independently many times and is remarkably diverse: the placenta. The placenta forms through the fusion of embryonic and maternal tissues to enable the transfer of nutrients\, waste\, and more during gestation. Placentas have evolved more than 100 times independently among vertebrates\, including once in mammals. Within a family of small live-bearing fishes known as Poeciliidae\, at least nine independent origins of the placenta have occurred. This makes them excellent models for studying how new organs emerge during evolution. We combined whole-genome sequencing\, single-cell RNA and ATAC sequencing\, and imaging to uncover the molecular\, cellular\, and developmental basis of five independent origins of a placenta in Poeciliids. We found that the evolution of a novel cell type unique to Poeciliids allowed this family to transition from egg-laying to live-bearing through egg retention. This cell type was subsequently and independently co-opted five times to form the placenta in five species. Across these independently evolved placentas\, we observe strong convergence at the molecular level\, with specific genes and pathways repeatedly recruited during placental evolution. Together\, our findings provide empirical support for a model in which cell-type innovation drives the emergence of new organs and demonstrate that major life history transitions can follow predictable developmental and molecular trajectories. \n\n\n\n \n\n\n\nHost: leif.andersson@imbim.uu.se UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-margarida-cardoso-moreira/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260216T151500 DTEND;TZID=Europe/Stockholm:20260216T161500 DTSTAMP:20260511T004504 CREATED:20260127T165258Z LAST-MODIFIED:20260127T165259Z UID:10001729-1771254900-1771258500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Microbiome data science for population-scale studies DESCRIPTION:Leo Lahti \n\n\n\nProfessor University of Turku\, Finland \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nLeo Lahti is professor in Data Science at the University of Turku\, vice chair of the National  Coordination on Open Science in Finland\, and a recent member of the global Bioconductor Community Advisory board. He obtained doctoral degree in applied probabilistic machine learning from Aalto University in Finland (2010) and had subsequently nearly a decade of international research experience in European labs. His research team focuses on computational microbiome research. For more information\, see the research homepage datascience.utu.fi \n\n\n\n \n\n\n\nMicrobiome data science for population-scale studies\n\n\n\nHuman microbiome is a major contributor to health and disease\, driven by environment and lifestyle. We will discuss recent advances in population cohort studies linking gut microbiome\, socio-demographic variation\, and health\, and the critical role of open data science frameworks in facilitating such research. \n\n\n\n \n\n\n\n\n\n\n\nHost: Luisa Hugerth luisa.hugerth@scilifelab.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-leo-lahti/ LOCATION:BMC Trippelrummet\, Husargatan 3\, entrance C11\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260216T140000 DTEND;TZID=Europe/Stockholm:20260216T150000 DTSTAMP:20260511T004504 CREATED:20260127T165907Z LAST-MODIFIED:20260127T165952Z UID:10001735-1771250400-1771254000@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Super-resolution imaging of chromatin in health and disease DESCRIPTION:Melike Lakadamyali \n\n\n\nProfessor University of Pennsylvania\, USA \n\n\n\n\n\n\n\nBio\n\n\n\nDr. Lakadamyali obtained her BS in Physics in 2001 from the University of Texas\, Austin and her PhD in Physics in 2006 from Harvard University. Dr. Lakadamyali started her independent group at ICFO-Institute of Photonic Sciences in Barcelona in 2010 and was awarded tenure in 2015. In 2017 she moved to the University of Pennsylvania´s Department of Physiology at the Perelman School of Medicine as an Assistant Professor\, was promoted to Associate Professor in 2020 and Full Professor in 2024. \n\n\n\nSuper-resolution imaging of chromatin in health and disease\n\n\n\nSuper-resolution microscopy has opened new possibilities for visualizing chromatin architecture in situ at nanoscale resolution. Leveraging quantitative super-resolution imaging\, we revealed the heterogeneous nature of nucleosome folding and demonstrated that chromatin structure at both nano- and meso-scales is highly plastic\, dynamically remodeling in response to chemical and mechanical cues in health and disease. By combining biologically interpretable feature extraction with machine learning\, we further showed that cells can be accurately classified into distinct states based solely on their multi-scale chromatin organization\, while also identifying the specific chromatin features that drive classification\, thus offering mechanistic insight into cell-state regulation. \n\n\n\n\n\n\n\nHost: Sebastian Deindl sebastian.deindl@icm.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-melike-lakadamyali/ LOCATION:BMC Trippelrummet\, Husargatan 3\, entrance C11\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20260126T151500 DTEND;TZID=Europe/Stockholm:20260126T161500 DTSTAMP:20260511T004504 CREATED:20251211T124150Z LAST-MODIFIED:20251211T124151Z UID:10001681-1769440500-1769444100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - How to Terminate Transcription at the Right Place DESCRIPTION:Gene‑Wei Li \n\n\n\nAssociate Professor Massachusetts Institute of Technology (MIT)\, USA \n\n\n\nBio\n\n\n\nGene‑Wei Li is an Associate Professor of Biology at Massachusetts Institute of Technology (MIT) and an Investigator at Howard Hughes Medical Institute (HHMI). He earned a B.S. in Physics from National Tsinghua University (2004) and a Ph.D. in Physics from Harvard University (2010)\, followed by a postdoctoral fellowship at University of California\, San Francisco (UCSF). His research focuses on how bacterial genomes encode quantitative control over protein production — exploring how cells optimize proteome composition through precise regulation of transcription\, translation\, and RNA processing. \n\n\n\nHow to Terminate Transcription at the Right Place \n\n\n\nPrecise transcription termination is essential for defining gene boundaries and achieving proper RNA output. I will discuss two recent advances regarding transcription termination in bacteria. First\, we re-defined the features required for intrinsic terminators: in addition to the canonical hairpin and U-tract\, two conserved sequence motifs are also necessary. This new definition quantitatively explains variations in termination efficiency and accurately pinpoints functional terminators genome-wide. Second\, we showed that many bacteria have evolved purine-rich genes to avoid premature transcription termination\, especially in species with “runaway transcription\,” i.e.\, those uncoupled transcription-translation. This bias imposes strong evolutionary constraints on codon usage and the assimilation of foreign genes. Together\, these principles illuminate the design principles of bacterial gene sequences and how genomes encode the correct endpoints of transcription \n\n\n\n \n\n\n\nHost: Johan Elf johan.elf@icm.uu.se UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-gene-wei-li/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251215T151500 DTEND;TZID=Europe/Stockholm:20251215T161500 DTSTAMP:20260511T004504 CREATED:20251120T123638Z LAST-MODIFIED:20251125T132656Z UID:10001670-1765811700-1765815300@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Optogenetic control of gene expression dynamics in single cells DESCRIPTION:Mary Dunlop \n\n\n\nProfessor Boston University\, USA \n\n\n\nBio\n\n\n\nMary Dunlop is a Professor of Biomedical Engineering and Dorf-Ebner Distinguished Faculty Fellow at Boston University. She holds additional affiliations in Bioinformatics and Molecular Biology\, Cell Biology & Biochemistry. She graduated from Princeton University with a B.S.E. in Mechanical and Aerospace Engineering and a minor in Computer Science. She then received her M.S. and Ph.D. in Mechanical Engineering from the California Institute of Technology. In recognition of her outstanding research contributions\, she has received many honors including election as an AIMBE Fellow\, the NSF Transitions Award\, ACS Synthetic Biology Young Investigator Award\, DOE Early Career Award\, and NSF CAREER Award. She is also the recipient of several mentoring and teaching awards\, including Boston University’s Award for Excellence in Mentoring Postdocs and the College of Engineering Teaching Excellence Award. \n\n\n\nOptogenetic control of gene expression dynamics in single cells \n\n\n\nEmerging approaches that integrate optogenetics with feedback control are transforming our ability to precisely manipulate microbial gene expression dynamics. In this talk\, I will present how we harnessed deep neural networks and model predictive control to impose real-time\, cell-specific gene expression patterns in bacteria\, revealing crucial links between dynamic regulation and functional outcomes such as antibiotic resistance. I will also highlight our use of optogenetic tools and information theory to understand how variable expression of a key transcription factor influences downstream stress response genes and impacts bacterial survival under antimicrobial stress. These approaches provide new insights into the significant roles of cellular heterogeneity and dynamic regulation\, advancing our understanding of gene expression and microbial behavior at the single-cell level. \n\n\n\n \n\n\n\nHost: Daniel Jones daniel.jones@icm.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-mary-dunlop/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251208T151500 DTEND;TZID=Europe/Stockholm:20251208T161500 DTSTAMP:20260511T004504 CREATED:20251120T122932Z LAST-MODIFIED:20251124T132739Z UID:10001669-1765206900-1765210500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - The origins of locally adaptive loci DESCRIPTION:Gabriela Montejo-Kovacevich \n\n\n\nAssistant Professor SciLifeLab Fellow Uppsala University \n\n\n\n\n\n\n\nBio\n\n\n\nGabriela Montejo-Kovacevich is a SciLifeLab fellow and Assistant Professor that recently established her lab at the Animal Ecology program in the Department of Ecology and Genetics at EBC (Uppsala University). Her group studies mechanisms that promote or constrain local adaptation. By integrating genomics with ecological and natural history approaches\, mainly in insects\, they explore the mode and tempo of evolution in natural populations. \n\n\n\nThe origins of locally adaptive lociHow do organisms evolve to inhabit diverse environments? This seminar explores the mode and tempo of evolution in the wild by studying local adaptation in three insect systems. I will first present work on Heliconius butterflies along a 1500m altitudinal gradient in the Andes\, revealing strong\, repeated selection at high-altitude\, with evidence for adaptive introgression from pre-adapted species. I will then turn to a ‘megapest’ moth (Helicoverpa) that is threatening food security in Brazil through bidirectional adaptive introgression conferring insecticide resistance. Finally\, I will introduce Euphydryas editha\, a Californian butterfly capable of rapid\, heritable shifts in host plant use offering a rare glimpse into ongoing behavioural adaptation to anthropogenic change. Together\, these systems demonstrate how evolutionary forces interact to shape resilience in a rapidly changing world. \n\n\n\nHost: Göran Arnqvist Goran.Arnqvist@ebc.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-gabriela-montejo-kovacevich/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251201T151500 DTEND;TZID=Europe/Stockholm:20251201T161500 DTSTAMP:20260511T004504 CREATED:20251119T104324Z LAST-MODIFIED:20251119T104326Z UID:10001668-1764602100-1764605700@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Genome organisation and patterns of molecular evolution DESCRIPTION:Jennifer James \n\n\n\nAssistant Professor DDLS Fellow \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nDr. Jennifer James did her PhD in population genetics with Adam Eyre-Walker at the University of Sussex. After a postdoctoral position at the University of Cambridge she moved to the US\, where she worked as a postdoctoral researcher with Joanna Masel at the University of Arizona\, which introduced her to the world of proteomics. She next moved to Uppsala and worked as a postdoctoral research fellow with Martin Lascoux prior to becoming a DDLS fellow and starting her own new research group in Molecular Evolution. Her group conducts research on patterns of molecular evolution both at the genome and proteome level\, with a focus on understanding mutational robustness. \n\n\n\n \n\n\n\n \n\n\n\nGenome organisation and patterns of molecular evolution\n\n\n\n \n\n\n\nIn my group\, we try to understand patterns of phenotypic evolution at the proteome level\, and molecular evolution across the genome. Key to this question is understanding how the genome is structured and organised. For example\, how pleiotropic are the effects of genes on average\, and how complex are gene networks? To give one case\, if pleiotropy is universal\, such that all genes affect all traits\, we expect all new mutations to have the same effect on fitness. However\, the extent of pleiotropy in real biological systems remains debated. In this seminar I will discuss our \n\n\n\n \n\n\n\nHost: Siv Andersson siv.andersson@icm.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-jennifer-james/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251117T151500 DTEND;TZID=Europe/Stockholm:20251117T161500 DTSTAMP:20260511T004504 CREATED:20251006T081235Z LAST-MODIFIED:20251107T122041Z UID:10001630-1763392500-1763396100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Coagulation: Cancer's new best friend DESCRIPTION:Gareth Owen \n\n\n\nProfessor Pontificia Universidad Católica de Chile\, Chile \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nDr. Gareth Owen is currently visiting Professor in the lab of Dr Masood Kamali-Moghaddam\, Department of Immunology\, Genetics and Pathology\, Uppsala University. He is a full professor in the Faculty of Biological Sciences and Faculty of Medicine at the Pontificia Universidad Catolica de Chile. Dr Owen did his BSc at King’s College London and has a PhD from the Royal Postgraduate Medical School\, Hammersmith Hospital\, London UK (Imperial College London).  This was followed by a post-doctoral fellowships at the University of Colorado USA\, and the Institute of Cancer Research (ICR-UK). Dr Owen is a PI in the Millennium Institute on Immunology and Immunotherapy Chile\, and Board member of the Chilean National Cancer Forum. \n\n\n\n \n\n\n\nCoagulation: Cancer’s new best friend\n\n\n\nCoagulation is linked to cancer progression\, with many patients exhibiting chronic hypercoagulability. Anticoagulant therapy has been associated with improved outcomes. Beyond hemostasis\, the coagulation system can drive inflammation and metastasis\, though the mechanisms remain unclear. Herein\, we demonstrate that elevated levels of activated coagulation factor X (FXa) increase lung metastasis and that FXa promotes an immunosuppressive tumor microenvironment. Using a murine model of melanoma and in vitro assays\, we found that FXa increased infiltration of regulatory T cells and Th17 cells\, and upregulated PD-1 and CTLA-4 expression on CD4+ and CD8+ T cells. Co-treatment with the anti-FXa anticoagulant dalteparin abrogated these effects. Mechanistically\, FXa in vitro suppressed macrophage M1 and Th1 differentiation through the Protease-Activated Receptor-1 (PAR1). The clinically approved PAR1 inhibitor Vorapaxar blocked FXa-induced tumor progression in vivo. These findings identify FXa or PAR1 inhibition as therapeutic strategies in cancer therapy. \n\n\n\n \n\n\n\nHost: Masood Kamali-Moghaddam masood.kamali@igp.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-gareth-owen/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251103T151500 DTEND;TZID=Europe/Stockholm:20251103T161500 DTSTAMP:20260511T004504 CREATED:20251023T143342Z LAST-MODIFIED:20251023T143343Z UID:10001645-1762182900-1762186500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Understanding and treating diabetes with stem cells islets DESCRIPTION:Maike Sander \n\n\n\nProfessor Charité in Berlin\, Germany \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nProf. Maike Sander’s research focuses on understanding the molecular mechanisms that regulate the formation and function of insulin-producing pancreatic beta cells\, aiming to develop new therapeutic approaches for diabetes. Her research combines genetic approaches in human stem cell–derived organoids with single-cell genomics to map pancreatic islet cell gene regulatory programs in health and disease. \n\n\n\nShe is a Professor at the Charité in Berlin\, Germany and the scientific director of the Max Delbrück Center. Prior to this\, she was a faculty member at the University of California\, San Diego\, where she led the Pediatric Diabetes Research Center. Her accolades include the Grodsky Award from the Juvenile Diabetes Research Foundation\, the Humboldt Research Award\, and the Albert Renold Prize from the European Association for the Study of Diabetes. She is an elected member of the American Society for Clinical Investigation\, the Association of American Physicians\, the German National Academy of Sciences\, EMBO\, and Academia Europaea. \n\n\n\n \n\n\n\nUnderstanding and treating diabetes with stem cells islets\n\n\n\n \n\n\n\nHuman pluripotent stem cell-derived islet cells offer an unlimited resource for diabetes research and cell therapy. Glucose-responsive\, insulin-secreting pseudo-islets (SC-islets) have been successfully generated from stem cells and are now in clinical trials for type 1 diabetes—a major step toward therapeutic use. These SC-islets comprise insulin-secreting beta cells and other endocrine cell types found in native pancreatic islets. However\, functional differences between SC-beta cells and primary human beta cells still limit their value as disease models. \n\n\n\nTo address this\, my laboratory developed an islet organoid model incorporating vascular and stromal cells within a microfluidic platform containing perfused human microvessels. Vascularization enhanced SC-beta cell function\, highlighting the importance of the islet niche. This advanced organoid system now serves as a powerful platform to study diabetes mechanisms and test therapeutics. \n\n\n\n \n\n\n\nHost: Olov Andersson olov.andersson@mcb.uu.se UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-maike-sander/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20251022T151500 DTEND;TZID=Europe/Stockholm:20251022T161500 DTSTAMP:20260511T004504 CREATED:20251006T082124Z LAST-MODIFIED:20251006T082126Z UID:10001631-1761146100-1761149700@www.scilifelab.se SUMMARY:[The Svedberg seminar]-Molecular Mechanism of RNA Splicing by the Spliceosome DESCRIPTION:Yigong ShiProfessor School of Life Sciences\, Westlake University\, Hangzhou\, China \n\n\n\n \n\n\n\nTHE LENNART PHILIPSON MEMORIAL LECTURE 2025 \n\n\n\nLecture hall A1:107a\, BMC\, Uppsala University Wednesday\, October 22\, 2025 at 3:15 pm   \n\n\n\nBio \n\n\n\nProfessor Yigong Shi is a biophysicist and the current president of Westlake University. He received aBachelor of Science from Tsinghua University in 1989 and a Doctor of Philosophy in molecularbiophysics from Johns Hopkins University in 1995. Yigong Shi has been the Warner-Lambert/Parke-Davis Professor in the department of Molecular Biology at Princeton University. Since 2008\, hecontinued his career at Tsinghua University\, where he was appointed Dean of Tsinghua’s School ofLife Sciences. In 2018\, he became the founding and first president of Westlake University\, a newlyestablished private university in Hangzhou.His laboratory combines structural biology\, biochemical and biophysical approaches to elucidate themolecular and chemical basis of fundamental cellular events\, with a particular interest inspliceosome-catalyzed pre-mRNA splicing\, the mechanism of regulated intramembrane proteolysis\,and the initiation of apoptosis.Yigong Shi’s laboratory has been working on the structural elucidation of the spliceosome since 2008.Initially\, his lab solved the crystal structures of select spliceosomal components. In the summer of2015\, they published two seminal papers on the intact\, functional yeast spliceosome structure at 3.6-Å resolution. Since then\, they have reported the cryo-EM structures of the yeast spliceosome inseven states and human spliceosome in three states\, which together elucidate the choreography ofthe assembly and catalysis of the spliceosome.Representative publications and an animation (https://ygshi.org/research?0) on the spliceosomehighlight the essence of this year’s Lennart Philipson Memorial Lecture:Hang J\, Wan R\, Yan C\, Shi Y. Structural basis of pre-mRNA splicing. Science. 2015;349(6253):1191-8.Yan C\, Hang J\, Wan R\, Huang M\, Wong CC\, Shi Y. Structure of a yeast spliceosome at 3.6-angstromresolution. Science. 2015;349(6253):1182-91. Yan C\, Wan R\, Shi Y. Molecular Mechanisms of premRNASplicing through Structural Biology of the Spliceosome. Cold Spring Harb Perspect Biol.2019;11(1):a032409.Welcome! URL:https://www.scilifelab.se/event/the-svedberg-seminar-yigong-shi/ LOCATION:BMC Lecture hall A1:107a\, BMC\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250924T151500 DTEND;TZID=Europe/Stockholm:20250924T161500 DTSTAMP:20260511T004504 CREATED:20250827T093947Z LAST-MODIFIED:20250908T133058Z UID:10001591-1758726900-1758730500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Metabolic Regulation of Longevity from Organelle to Organism DESCRIPTION:Meng Wang \n\n\n\nPhD\, Senior Group LeaderJanelia Research Campus\, US \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\n\n\n\n\nDr. Meng Wang is currently a Senior Group Leader at HHMI Janelia Research Campus. She received a B.S. degree from Peking University\, China in 2001 and a Ph.D. degree from University of Rochester in 2005. After being a postdoctoral follow at Harvard Medical School\, Dr. Wang joined the faculty of Baylor College of Medicine in 2010. Before moving to Janelia in 2022\, she was an HHMI Investigator\, a Professor and the Robert C. Fyfe Endowed Chair on Aging at Baylor College of Medicine (BCM)\, as well as a co-director of the BCM Genetics and Genomics Graduate Program. Dr. Wang’s research focuses on metabolic signals in regulating lifespan and healthspan\, through harnessing the power of genomic screening\, multi-omic profiling\, chemical engineering and optical biophysics. Her group uncovered that lysosomes act as a central hub for integrating metabolism and signal transduction to modulate cellular homeostasis and organismal fitness\, and demonstrated a novel mode of signaling communication between bacteria and mitochondria in regulating host’s lipid metabolism and longevity. Technological developments in Dr. Wang’s laboratory have provided brand new ways to visualize and track metabolic molecules as a function of time and space in living cells and organisms. She is the recipient of NIH Director’s Pioneer Award\, Peter O’Donnell Award\, HHMI Faculty Scholar Award\, ASCB Gibco Emerging Leader Prize\, ASCB Early Career Life Scientist Award\, and Glenn Award for Research in Biological Mechanisms of Aging. She is an elected fellow of the American Association for the Advancement of Science and the American Society for Cell Biology. \n\n\n\n \n\n\n\nMetabolic Regulation of Longevity from Organelle to Organism\n\n\n\nDr. Wang’s research aims to decode the chemical language that governs cellular homeostasis and organismal healthspan. A central question in biology is how cells maintain homeostasis while adapting to continuous internal and external fluctuations. Metabolic activity\, a cornerstone of cellular homeostasis\, generates metabolites that are essential for cellular functions and highly conserved across species. Her lab has discovered that these metabolites can act as communication cues operating across multiple spatial scales\, from organelles to whole organisms\, through specific signaling mechanisms. This metabolic perspective links cellular dynamics with organismal physiology\, offering novel strategies to promote healthy aging and longevity. In parallel with these mechanistic studies\, her group has contributed to the development and application of cutting-edge imaging platforms that enable the study of metabolism in both space and time. These technological advances have revealed previously unknown spatial heterogeneity in metabolic organization and allowed high-resolution tracking of metabolic changes during aging \n\n\n\n \n\n\n\nHost: Yunjian Xu yunjian.xu@mcb.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-meng-wang/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250908T151500 DTEND;TZID=Europe/Stockholm:20250908T161500 DTSTAMP:20260511T004504 CREATED:20250822T070029Z LAST-MODIFIED:20250908T132850Z UID:10001586-1757344500-1757348100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Liquid Biopsy: From Discovery to Clinical Application DESCRIPTION:Catherine Alix-Panabières \n\n\n\nProfessor of OncologyUniversity Medical Center of Montpellier\, France \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\n\n\n\n\nCatherine Alix-Panabières is a Professor of Oncology and the Director of the ‘Laboratoire de Cellules Circulantes Humaines Rares et Biopsie Liquide’ (LCCRH) at Montpellier University Hospital and the Faculty of Medicine. Since 2022\, she has also held the position of Professor at the University of Hamburg in Germany. A specialist in circulating tumor cell (CTC) research for 26 years\, she is credited with coining the term “liquid biopsy” in 2010\, in collaboration with Prof. Pantel. Professor Alix-Panabières instructs students in this subject at academic institutions in France and abroad\, has organized numerous international conferences\, has published over 165 scientific articles and numerous chapters in books and encyclopedias\, has filed three patents and has collaborated on numerous European\, American\, and Asian research projects. Her most significant contribution is the demonstration of the clinical utility of CTCs in breast cancer. She has been the recipient of numerous accolades in France and abroad\, including the “Gallet et Breton” prize in 2012 and the “Berthe Péan\, Antoine et Claude Béclère” prize in 2023\, bestowed by the Académie Nationale de Médecine. In 2022\, she played a pivotal role in the cancer exhibition at the Cité des Sciences et de l’Industrie (Paris)\, which was curated by the National Institute of Cancer (INCa). Furthermore\, the esteemed journal Nature\, in its December 2020 issue\, acknowledged the significance of liquid biopsy as a pivotal advancement in cancer research over the past two decades and showcased the contributions of Prof. Alix-Panabières throughout her career. \n\n\n\n \n\n\n\nLiquid Biopsy: From Discovery to Clinical Application\n\n\n\nThis lecture explores how circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have transformed cancer research and clinical care. I will provide an overview of current technologies for detecting these biomarkers\, detailing their biology and their role in real-time monitoring of cancer progression. Advances now enable genomic\, transcriptomic\, and proteomic profiling of CTCs\, as well as functional studies using patient-derived cell lines. Likewise\, ctDNA offers a non-invasive method to track tumor evolution and minimal residual disease. The lecture will highlight how CTC and ctDNA analyses have deepened our understanding of metastasis and therapy response. Expanding the definition of liquid biopsy to include tumor-induced immune components—such as immune cells\, cytokines\, and interleukins—could offer a more comprehensive view\, particularly in the context of immunotherapy. I will conclude by discussing how CTC and ctDNA research uncovers mechanisms of immune escape and may guide the development of innovative strategies to improve cancer treatment. \n\n\n\nHost: Masood Kamali-Moghaddam masood.kamali@igp.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-catherine-alix-panabieres/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250512T151500 DTEND;TZID=Europe/Stockholm:20250512T161500 DTSTAMP:20260511T004504 CREATED:20250423T092440Z LAST-MODIFIED:20250424T080516Z UID:10001534-1747062900-1747066500@www.scilifelab.se SUMMARY:[The Svedberg seminar] Extracting meaning from high-throughput functional genomics data with Bayesian statistics DESCRIPTION:High-throughput functional genomics technologies have transformed infection biology into an increasingly data-driven science\, yet extracting meaningful insights from complex experiments remains challenging. Bayesian hierarchical modeling addresses these challenges by providing a framework to reason about the underlying data generating process. Here\, I illustrate the power of this approach through two case studies. First\, Bayesian modeling of RNA decay dynamics in Salmonella enterica identified confounding factors significantly biasing previous global RNA half-life estimates and revealed novel functions of bacterial RNA-binding proteins via transcriptome-wide differential stability analysis. Second\, we designed and analyzed a genome-wide transposon insertion screen for Shigella flexneri in a realistic human organoid infection model\, accounting for population bottlenecks and uncovering an unexpected role for bacterial tRNA modification enzymes in regulating virulence. I will end with an outlook on scaling our approach to very large datasets in the context of bacterial single-cell RNA-seq. \n\n\n\nLars Barquist\, Assistant Professor University of Toronto\, Canada \n\n\n\nHost: Maria Letizia Di Martino ml.dimartino@imbim.uu.se and Mikael Sellin mikael.sellin@imbim.uu.se \n\n\n\nBio\n\n\n\nLars received his PhD from Cambridge University for work on high-throughput and computational methods for studying pathogen evolution at the Wellcome Sanger Institute. After an Alexander von Humboldt postdoctoral fellowship\, he went on to start his own research group in 2018 at the Helmholtz Institute for RNA-based Infection Research in Würzburg\, Germany before recently moving to the University of Toronto. His work spans a broad range of topics at the interface of infection and computational biology\, ranging from large-scale comparative pathogen genomics and genotype-to-phenotype inference to detailed molecular studies of regulatory mechanisms and translational applications in antibiotic development. URL:https://www.scilifelab.se/event/the-svedberg-seminar-lars-barquist/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250422T151500 DTEND;TZID=Europe/Stockholm:20250422T161500 DTSTAMP:20260511T004504 CREATED:20250409T070149Z LAST-MODIFIED:20250409T070826Z UID:10001525-1745334900-1745338500@www.scilifelab.se SUMMARY:[The Svedberg seminar]-The origins and functional evolution of amniote sex chromosomes DESCRIPTION:Henrik Kaessmann \n\n\n\nProfessor of Evolutionary Genomics at Heidelberg \, Germany \n\n\n\nBio\n\n\n\nDr. Henrik Kaessmann is Professor of Evolutionary Genomics at Heidelberg University. His research focuses on the molecular foundations of mammalian phenotypic evolution\, leveraging various comparative and functional genomics approaches. After earning his Ph.D. at the Max Planck Institute for Evolutionary Anthropology\, he conducted postdoctoral research at the University of Chicago as an EMBO Fellow. His interdisciplinary lab\, which he initially established in Lausanne (Switzerland)\, has pioneered large-scale studies of gene expression changes and their phenotypic implications across various biological dimensions\, including organs\, species\, developmental stages\, gene expression layers\, coding and noncoding gene types\, splicing isoforms\, and sexes. Prof. Kaessmann has published extensively in leading journals and has received numerous prestigious honors\, including three ERC grants\, EMBO membership\, the Friedrich Miescher Award\, and the Cloëtta Prize. Beyond his research\, he teaches and mentors at Heidelberg University and maintains active collaborations with clinical researchers and major scientific institutions worldwide.Collectively\, Henrik Kaessmann’s transformative work has profoundly advanced our understanding of the molecular foundations of mammalian phenotypic evolution and the driving forces of natural selection. The remarkable scope of his lab‘s major findings demonstrates how large-scale genomics approaches can yield fundamental biological insights and test key hypotheses. Notably\, his interdisciplinary research has had far-reaching impact beyond evolution and development\, as evidenced by extensive citations across diverse fields. His findings\, including the observation of functional divergence of many genes between humans and mice\, and unique gene expression (i.e.\, transcriptome\, epigenome\, translatome) datasets  spanning key organs and developmental stages in humans and various model and non-model species\, have become indispensable resources for biomedical research in general. To maximize their impact\, his team has created interactive public databases that ensure optimal usability for the scientific community. \n\n\n\n \n\n\n\nThe origins and functional evolution of amniote sex chromosomes\n\n\n\n In our lab\, we carry out large-scale studies of gene expression changes and their phenotypic implications across various biological dimensions (e.g.\, species\, organs\, developmental stages\, gene expression layers\, coding and noncoding gene types\, splicing isoforms\, and sexes). In this seminar\, I will focus on our endeavors to unravel the origins of the different amniote sex chromosome systems\, which emerged from ancestral sets of autosomes. We have\, for example\, unveiled the origins of the sex chromosomes of therian (i.e.\, placental and marsupial) and monotreme mammals\, and those of birds and lizards. We then scrutinized the evolutionary and functional consequences of sex chromosome differentiations (i.e.\, the degeneration of Y or W chromosomes in males or females\, respectively) and the associated selective forces. Overall\, our work has illuminated the evolution of the specific gene contents on the respective sex chromosomes\, the origins and consequences of male (meiotic) sex chromosome inactivation\, and the forces and mechanisms underlying the evolution of the various amniote dosage compensation mechanisms\, including the drivers underlying the emergence of the female X inactivation mechanism in therians. I will present published and unpublished highlights of our work \n\n\n\nHost: Leif Andersson leif.andersson@imbim.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-henrik-kaessmann/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250407T151500 DTEND;TZID=Europe/Stockholm:20250407T161500 DTSTAMP:20260511T004504 CREATED:20250324T130645Z LAST-MODIFIED:20250324T130745Z UID:10001512-1744038900-1744042500@www.scilifelab.se SUMMARY:[The Svedberg seminar]-Navigating Lipid Metabolism:  From Basic Molecular Mechanisms to Cellular Symphony DESCRIPTION:Aditi Das\n\n\n\nProfessor School of Chemistry and Biochemistry Georgia Institute of Technology\, USA \n\n\n\nBio\n\n\n\nDr. Aditi Das is a Professor in the School of Chemistry and Biochemistry at Georgia Institute of Technology (Georgia Tech). Her research explores lipid biochemistry\, enzymology\, and drug metabolism\, with a focus on bioactive metabolites and their roles in inflammation and neurodegenerative diseases. She earned her Ph.D. in chemistry from Princeton University\, specializing in functional protein design\, followed by postdoctoral research utilizing biophysical tools to study membrane proteins in Nanodiscs. Dr. Das has made significant contributions to understanding cytochrome P450 enzymes and their role in lipid oxidation\, leading to advances in drug discovery and biomedical applications. Her work has been widely published in high-impact journals\, and she has received numerous grants and awards. Her national accolades include the NIH R35 Outstanding Researcher Award\, the E.L.R. Stokstad Award\, and the Mary Swartz Rose Young Investigator Award from the American Society for Nutrition. Beyond her research\, she serves on the Editorial Advisory Boards of Molecular Pharmacology and Frontiers in Pharmacology. Through her work\, Dr. Das continues to advance the fields of lipid biochemistry and cannabinoid metabolism\, translating fundamental science into real-world applications for human health. \n\n\n\n \n\n\n\nNavigating Lipid Metabolism:  From Basic Molecular Mechanisms to Cellular Symphony\n\n\n\nLipids are vital for cellular functions\, acting as structural components\, signaling molecules\, and energy sources. Their metabolism\, particularly through cytochrome P450s and other oxidizing enzymes\, plays a key role in inflammation and disease. This study uses biochemical\, analytical\, and biophysical methods to examine the metabolism of endocannabinoids and cannabinoids by membrane-bound cytochrome P450s\, stabilized in nanoscale lipid bilayers (Nanodiscs). The pharmacological properties of lipid metabolites are evaluated\, focusing on their impact on inflammation and pain receptor modulation. The study also explores the metabolism of minor cannabinoids like cannabinol (CBN)\, cannabigerol (CBG)\, and cannabichromene (CBC)\, which provide medicinal benefits without THC’s psychoactive effects. Computational modeling helps further understand binding mechanisms\, and in vitro studies confirm the bioactivity of these metabolites. This integrated approach enhances our understanding of lipid metabolism and cannabinoid pharmacology\, supporting the development of therapeutic strategies for pain and inflammatory diseases. \n\n\n\nHost: Peter Kasson peter.kasson@icm.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-aditi-das/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250310T151500 DTEND;TZID=Europe/Stockholm:20250310T161500 DTSTAMP:20260511T004504 CREATED:20250123T150313Z LAST-MODIFIED:20250210T141539Z UID:10001461-1741619700-1741623300@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Human beta cell protection by Nature DESCRIPTION:Bart RoepProfessorLeiden University Medical Center\, Netherlands \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nBart Roep is Professor of Medicine & Professor of Diabetology\, Immunopathology and Intervention at the Department of Internal Medicine\, Leiden University Medical Center\, Leiden\, Netherlands\, where he heads the Section Immuno-modulation & Regenerative Medicine. He studied Medicine and Life Sciences at the University of Amsterdam and obtained his PhD in Medicine at Leiden University. He pioneered studies on the role of T-cells in the pathogenesis of T1D and discovered some of their targets in β-cells\, provided seminal proof of their role in human β-cell destruction and defined immune correlates of disease progression and therapeutic intervention. He contributed to a suite of clinical intervention trials in T1D\, including pioneering strategies on tissue-specific tolerance induction\, regenerative medicine\, gene and stem cell therapy\, faecal microbiome transplantation and β-cell replacement therapies (pancreatic donor islets and embryonic stem cell derived β-cell progenitors). A profound twist in prevalent belief of the immunopathogenesis involved his discovery of the role of β-cells in their own demise. His current focus is on regenerative medicine in T1D from an immunological perspective. \n\n\n\nHuman beta cell protection by Nature\n\n\n\nType 1 diabetes results from an autoimmune mediated destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans in people with genetic predisposition to develop this disease. Insulin gene (INS) variation and beta-cell stress associate with risk for development of type 1 diabetes  (T1D) and autoimmunity against insulin. We discovered the relationship between ER stress and insulin mRNA from INS risk variants in human β-cells\, and how this variation relates to β-cells function\, stress and immunogenicity. This novel explanation for genetic protection from T1D inferred by INS polymorphism\, puts β-cells in the center of T1D pathogenesis. Beta cells carrying this particular protective INSP variant can alleviate ER stress by insulin mRNA decay\, resulting in reduced immunogenicity and improved islet function. We propose that INSP is a causal variant contributing to genetic protection from T1D. The clinical and therapeutic implications of this discovery will be discussed. \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nHost: Olov Andersson olov.andersson@mcb.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-bart-roep/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250219T151500 DTEND;TZID=Europe/Stockholm:20250219T161500 DTSTAMP:20260511T004504 CREATED:20250210T171944Z LAST-MODIFIED:20250211T101304Z UID:10001484-1739978100-1739981700@www.scilifelab.se SUMMARY:[The Svedberg seminar]-Imaging the molecular processes of cell division across scale DESCRIPTION:Jan EllenbergProfessor Karolinska Institutet Stockholm\, Sweden and European Molecular Biology Laboratory\, Heidelberg\, Germany Director\, Science for Life Laboratory\, Sweden \n\n\n\n \n\n\n\nTHE LENNART PHILIPSON MEMORIAL LECTURE2025 \n\n\n\nLecture hall A1:107a\, BMC\, Uppsala University Wednesday\, February 19\, 2025 at 3:15 pm   \n\n\n\nBio \n\n\n\nProf. Jan Ellenberg Professor Ellenberg is renowned for his groundbreaking research in cell biology\, particularly in the areas of advanced imaging and the study of cell division. His approach of the so-called 4D dynamic change of molecular structures in living cells\, studied in individual\, and all the way into cells\, embedded in organismal tissues has generated new insight and opened immense technological potential. Dr. Ellenberg has been a group leader at the European Molecular Biology Laboratory (EMBL) since 1999\, the head of the Gene Expression Unit between 2006-2010 and the head of the Cell Biology and Biophysics Unit since 2010. He has been coordinating infrastructure development within EMBL and at the European level. Since July 2024\, Dr. Ellenberg has been acting as the Director of SciLifeLab in Sweden\, became Professor at Karolinska Institutet and an Affiliated Professor at Stockholm University and KTH Royal Institute of Technology. A single (!) representative publication out of the long series of top articles published by Ellenberg and his group highlights the essence of this year’s Lennart Philipson Memorial lecture: Gerlich D\, Ellenberg J. 4D imaging to assay complex dynamics in live specimens. Nat Cell Biol. 2003; Suppl: S14-9. Welcome! URL:https://www.scilifelab.se/event/the-svedberg-seminar-jan-ellenberg/ LOCATION:BMC Lecture hall A1:107a\, BMC\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250210T151500 DTEND;TZID=Europe/Stockholm:20250210T161500 DTSTAMP:20260511T004504 CREATED:20250121T074231Z LAST-MODIFIED:20250210T140803Z UID:10001456-1739200500-1739204100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - On giant lungfish genomes and the genomics of adaptations and speciation in hyperdiverse cichlid fish radiations DESCRIPTION:Axel MeyerProfessorUniversity of Konstanz\, Germany \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nAxel Meyer (*1960 in Lübeck) studied biology at the Universities of Marburg and Kiel in Germany before he moved to the USA in 1982. At the University of California he received his Master (1985) and PhD (1988) degrees in Berkeley’s Department of Zoology. For the last year of his PhD he worked in the Biochemistry Department in lab of Allan C. Wilson at Berkeley. There he was part of a team that was the first to use PCR for questions in molecular evolution\, phylogenetics\, and ancient DNA. As an Alfred P. Sloan Postdoc he continued to work with Allan Wilson in the Biochemistry Department at Berkeley until 1990 when he became an Assistant and then (since 1993) Associate Professor in the Ecology and Evolution Department at Stony Brook\, NY. In 1997 he returned to Germany as Chair in Zoology and Evolutionary Biology at the University of Konstanz. He is a member of several academies\, including EMBO\, the Academia Europaea\, the Berlin Academy of Sciences\, the German National Academy Leopoldina\, and The American Academy of Arts and Sciences  and received a numerous awards and fellowships including Fulbright and Guggenheim Fellowships\, the Carus Medal of the Leopoldina\, and a Hector Prize. Axel Meyer’s research focuses on fundamental questions in evolutionary biology and comparative genomics with a focus on speciation\, Hox genes\, genomics of adaptations\, and gene and genome duplications. He was among the first to confirm Susumo Ohno’s suggestion that all modern fishes are derived from a lineage that experienced an additional (the teleost-specific genome duplication\, TSGD) genome duplication. Meyer received the EMBO award for communications in the life sciences for his efforts to communicate science to the public. He has a science podcast for Cicero Magazin\, wrote a popular science book on the biology of men and women\, and had a weekly column for the financial newspaper Handelsblatt. Besides Konstanz he is affiliated with the SCSIO in Guangzhou and the Museum of Comparative Zoology at Harvard University \n\n\n\nOn giant lungfish genomes and the genomics of adaptations and speciation in hyperdiverse cichlid fish radiations\n\n\n\nLungfishes are the closest living relatives to tetrapods among the “fishes”. Their genomes are the largest animal genomes\, composed of over 90% repetitive DNA\, and their size\, 3-15x larger than the human genome (~45-92Gb)\, makes them difficult to assemble and interpret. The analyses of these genomes revealed the genetics of some pre-adaptations (respiration\, locomotion\, nitrogen excretion\, olfaction) that might have permitted their relatives to conquer land in the Devonian and to give rise to all land vertebrates. While lungfishes are ancient “living fossils” that appear not have changed for >100 Million years\, the cichlid fishes of the East African Great lakes and of Nicaragua’s crater lakes have speciated and morphologically diversified at record speeds. New species formed within a few hundred generations and several phenotypic innovations evolved repeatedly and due to structural variants and transposable element activity. \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nHost: Dan Larhammar dan.larhammar@uu.se\, Per Ahlberg Per.Ahlberg@ebc.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-axel-meyer/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240603T151500 DTEND;TZID=Europe/Stockholm:20240603T161500 DTSTAMP:20260511T004504 CREATED:20240503T152931Z LAST-MODIFIED:20240503T152932Z UID:10001253-1717427700-1717431300@www.scilifelab.se SUMMARY:[The Svedberg seminar] Combining artificial intelligence approaches and cellular screens to define functional regulatory variation in mammalian genomes DESCRIPTION:James Prendergast \n\n\n\nProfessorRoslin Institute\, University of Edinburgh- UK \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nJames Prendergast is professor of bioinformatics at the Roslin Institute in Edinburgh. His academic journey began with a focus on the genetics of colorectal cancer during the early days of genome-wide association studies\, leading to a PhD in Bioinformatics and Statistical Genetics from the University of Edinburgh in 2007. \n\n\n\nAfter completing his PhD\, James held post-doctoral positions at the European Bioinformatics Institute and University College Dublin\, before joining the Human Genetics Unit at the University of Edinburgh. In 2013\, he transitioned to livestock research\, first joining the Roslin Institute on a career-track fellowship. \n\n\n\nThrough his career\, James has been part of several international consortia\, including the FAANG BovReg project\, Bridget\, FANTOM\, and the Bovine Pangenome Consortium. These collaborations have allowed him to continue to work across both human and livestock genetics research. \n\n\n\n \n\n\n\nCombining artificial intelligence approaches and cellular screens to define functional regulatory variation in mammalian genomes\n\n\n\n \n\n\n\nDespite significant progress\, the exact genetic variants that influence crucial mammalian traits and phenotypes often remain unknown. This uncertainty presents a significant challenge to the enhancement of livestock health and production through cutting-edge genomic approaches like genome editing. While predicting functional coding variants is comparatively straightforward\, it is suggested that regulatory variants are the primary drivers of phenotypic differences between individuals. In this talk\, I will delve into our efforts to bridge this knowledge gap by integrating novel cellular screen datasets and AI workflows to predict functional regulatory variants in mammalian genomes. This includes the pioneering application of the Survey of Regulatory Elements (SuRE) approach to cattle\, where we have scrutinized the regulatory impact of tens of millions of cattle variants\, while effectively eliminating the confounding effect of linkage disequilibrium that hampers other methodologies. I will demonstrate how these strategies can not only effectively prioritize regulatory variants in both humans and cattle\, but also identify those variants associated with significant phenotypes in each species. \n\n\n\n \n\n\n\n\n\n\n\n Host: Gabriella Lindgren\, SLU and Jennifer Meadows\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-james-prendergast/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240522T151500 DTEND;TZID=Europe/Stockholm:20240522T161500 DTSTAMP:20260511T004504 CREATED:20240503T151406Z LAST-MODIFIED:20240503T151408Z UID:10001252-1716390900-1716394500@www.scilifelab.se SUMMARY:[The Svedberg seminar] Mechanisms of Transcriptional Regulation of Drosophila & Mammalian Genomes DESCRIPTION:John Lis \n\n\n\nProfessor of Molecular Biology and GeneticsCornell University\, USA \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nDr\, Lis received his B.S degree in Chemistry from Fairfield University\, and his Ph.D. in Biochemistry from Brandeis University. His postdoctoral work at Stanford University focused on molecular genetics and was supported by a Helen Hay Whitney Foundation Fellowship. Dr. Lis joined the faculty at Cornell in 1978 and served as Chairman of the Section of Biochemistry\, Molecular & Cell Biology in the 1990s. He is now the Barbara McClintock Professor of Molecular Biology and Genetics and a member of the American Academy of Arts and Sciences and the National Academy of Sciences. Dr. Lis’ group develops new approaches to study the molecular mechanisms of transcription regulation\, and he uses these newly developed and existing technologies in both focused studies of highly-regulated genes and in comprehensive analyses of gene regulation of Drosophila and human genomes. A Harvey Lecture at Rockefeller University summarizes some of his past work that can be accessed using the following link. https://harveysociety.org/videos/video.php?series=114&lecture=1&wvideo=7810nzrdc0 \n\n\n\n \n\n\n\nMechanisms of Transcriptional Regulation of Drosophila & Mammalian Genomes \n\n\n\nTranscription by RNA Polymerase II (Pol II)\, the enzyme responsible for all mRNA synthesis\, is highly regulated by protein factors at multiple steps in the transcription cycle. Two critical regulatory steps\, whose regulatory integration is critical for the sophisticated gene regulation seen in multicellular eukaryotes\, are 1) the recruitment of Pol II to promoters where it rapidly initiates transcription and can enter into a promoter-proximal\, paused state 20-50 base pairs from the initiation site; and 2) the release of paused Pol II into productive elongation. Promoter-proximal pausing is dependent on protein complexes DSIF (DRB Sensitivity Inducing Factor) and NELF (Negative Elongation Factor) bind to Pol II early in transcription to stabilize pausing. Pause release occurs upon phosphorylation of Pol II\, DSIF and NELF by the Cdk9\, Cyclin T1 heterodimer P-TEFb (Positive Transcription Elongation Factor b). Several elongation factors\, e.g.\, PAF1 and Spt6\, engage with Pol II in its transition from its promoter-proximal pause to productive elongation. Although Pol II pausing is a key step in transcription regulation and has been extensively studied\, the molecular mechanisms of pausing and pause release to productive elongation are far from being completely understood. Furthermore\, recent studies have led to competing molecular mechanisms on the role of promoter-proximal pausing in the control of transcription. In this seminar\, I will describe the evolution of our understanding of transcription regulation as well as describe our latest efforts to advance and resolve this understanding using a variety of state-of-the-art genomic and optical methods in Drosophila and mammals \n\n\n\n \n\n\n\n\n\n\n\nHost: Anniina Vihervaara anniina.vihervaara@scilifelab.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-john-lis/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240520T151500 DTEND;TZID=Europe/Stockholm:20240520T161500 DTSTAMP:20260511T004504 CREATED:20240409T150428Z LAST-MODIFIED:20240409T150428Z UID:10001213-1716218100-1716221700@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Multilevel drift and selection in the evolution of prokaryotic plasmids DESCRIPTION:Tal Dagan \n\n\n\nProfessorInstitute of general microbiology\, Kiel University\, Germany. \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nProf. Tal Dagan graduated her PhD in 2005 and moved to Germany for her postdoctoral studies. Since 2013 she is a professor of microbiology at Kiel University. Her main research interest is microbial genome evolution via lateral gene transfer with a focus on the evolution of prokaryotic plasmids \n\n\n\n \n\n\n\nMultilevel drift and selection in the evolution of prokaryotic plasmids\n\n\n\nPlasmids are an extrachromosomal genetic elements that populate prokaryote cells. Due to their interaction with a hosting cell\, drift and selection operate on plasmid alleles at two hierarchical levels: the collective of plasmids within the host and the collective of cells within the host population. The effect of these two levels on plasmid evolution remains understudied. Using experimental evolution approach integrated with phylogenomic reconstruction we found that: i) drift and selection at the level of the host population leads to contrasting effects on the plasmid fitness and ii) segregational drift of plasmid alleles during cell division constrains the rate of plasmid evolution. Our findings may apply for the evolution of other extrachromosomal genetic elements having a similar population structure. Focusing on plasmids\, our research thus uncovers general principles in the evolution of autonomously replicating genetic elements. \n\n\n\n \n\n\n\n\n\n\n\nHost: Maliheh Mehrshad maliheh.mehrshad@slu.se\, SLU and Helen Wang helen.wang@imbim.uu.se UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-tal-dagan/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240506T151500 DTEND;TZID=Europe/Stockholm:20240506T161500 DTSTAMP:20260511T004504 CREATED:20240409T150217Z LAST-MODIFIED:20240411T124823Z UID:10001227-1715008500-1715012100@www.scilifelab.se SUMMARY:[The Svedberg seminar] Genetics of Type 2 Diabetes: Advances\, Prospects\, and Challenges DESCRIPTION:Benjamin F. Voight \n\n\n\nAssociate Professor\, Pharmacology and GeneticsUniversity of Pennsylvania – Perelman School of Medicine\, USA \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nBen Voight received his PhD from the University of Chicago\, with postdoctoral training at Massachusetts General Hospital\, staying on at the Broad Institute as a research scientist. He is currently an Associate Professor at the University of Pennsylvania in the Department of Systems Pharmacology and Translational Therapeutics\, and the Department of Genetics. As a human geneticist\, research from his group focuses on understanding the genetic\, biological\, and evolutionary basis of metabolic phenotypes in human populations\, particularly diabetes\, cardiovascular\, and liver disease. Recent data scientific efforts focus on new association studies for discovery using biobank-scale data (e.g.\, the Million Veteran Program)\, post-association study analyses to understand the genetic architecture of disease and ultimately the underlying causal variants\, and quantitative trait locus mapping for expression and chromatic accessibility using primary pancreas and liver data sets. \n\n\n\n \n\n\n\nGenetics of Type 2 Diabetes: Advances\, Prospects\, and Challenges\n\n\n\n \n\n\n\nType 2 diabetes is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms. Elucidating the processes and mechanisms by identifying new loci associated with disease\, the underlying causal variants and genes\, and the cell types of action are areas of current focus by the research community. I will describe recent contributions by the Type 2 Diabetes Global Genomic Initiative\, our newly minted consortium focused on expanding locus discovery across diverse ancestries\, understanding physiological mechanism and prediction of susceptibility to complications through genetic subtyping\, and nomination of putative causal genes and mechanism through statistical colocalization. I will also briefly discuss prospects for exciting potential advances in the near term from new data types and improved computational methods\, as well as my perceptions of open challenges and potential thoughts on how to take those on – ultimately to understand disease etiology and to generate prospects for therapeutic intervention. \n\n\n\n \n\n\n\n\n\n\n\nHost: Marcel den Hoed marcel.den_hoed@igp.uu.se UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-benjamin-voight/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240408T151500 DTEND;TZID=Europe/Stockholm:20240408T161500 DTSTAMP:20260511T004504 CREATED:20240326T080916Z LAST-MODIFIED:20240327T160812Z UID:10001212-1712589300-1712592900@www.scilifelab.se SUMMARY:Extracellular vesicles in cancer therapy-role of checkpoint molecules DESCRIPTION:Susanne Gabrielsson \n\n\n\nProfessorKarolinska Institutet \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nProf. Gabrielsson has after her PhD at Stockholm University and a postdoc at the Curie Institute in Paris\, established a group dedicated to extracellular vesicle (EV)/exosome research at the Karolinska Institutet. She has been a pioneer in the field of immune effects of exosomes. Dr. Gabrielsson was the first to describe the presence of exosomes in bronchoalveolar lavage fluid\, as well as in breast milk. Her work has revealed that EVs are major players in lung diseases such as asthma and sarcoidosis\, where they contribute to inflammation. Her studies in animal models give new insights into how EV based therapies can be optimized for immunotherapeutic applications in cancer. \n\n\n\n \n\n\n\nExtracellular vesicles in cancer therapy-role of checkpoint molecules\n\n\n\n \n\n\n\nThe talk will focus on their work to use EVs for cancer therapy. They lately showed that EVs can induce response to checkpoint inhibitors in a treatment refractory model (Veerman et al\, 2023)\, and they are now investigating the role of PD-1 and PD-L1 on EVs by investigating immune responses to EVs from PD-1 and PD-L1 KO mice. \n\n\n\n \n\n\n\n\n\n\n\nHost: Masood Kamali-Moghaddam masood.kamali@igp.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-susanne-gabrielsson/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240226T151500 DTEND;TZID=Europe/Stockholm:20240226T161500 DTSTAMP:20260511T004504 CREATED:20240207T162516Z LAST-MODIFIED:20240207T162519Z UID:10001149-1708960500-1708964100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Spatial biodiversity modeling with remote sensing and AI DESCRIPTION:Tobias Andermann \n\n\n\nAssistant Professor\, DDLS fellowUppsala University \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nTobias Andermann is a biodiversity researcher dedicated to providing data and computatio- nal tools for combating the global biodiversity crisis. His group\, the Biodiversity Data Lab\, is working on the intersection of molecular biology\, spatial ecology\, and machine learning\, with the mission to provide a more comprehensive view on the distribution of biodiversity\, including hidden diversity of inconspicuous and even undescribed species through the use of environmental DNA. \n\n\n\n \n\n\n\nSpatial biodiversity modeling with remote sensing and AI\n\n\n\nThere is an ever-increasing need for developing standardized ways of quantifying the biodiversity value of a site. This need arises from international and local policies (e.g. the COP15 UN Biodiversity agreement) as well as from the independent investments of companies world-wide in developing biodiversity-positive profiles\, motivated by their public perception. This momentum provides an unprecedented opportunity to efficiently protect biodiversity on a large scale to turn around the alarmingly negative biodiversity trends of the recent decades and centuries. While individual biodiversity assessments for specific sites can be done through targeted inventories\, either through taxonomic experts or increasingly through the use of environmental DNA\, we also need ways of scaling up such biodiversity evaluations to larger scales\, covering entire regions or countries. AI models provide a unique tool to leverage complex biodiversity and remote sensing data to make predictions of biodiversity on large spatial scales\, while at the same time providing high spatial resolution. In this talk I will present some of these models from my ongoing research and discuss their utility\, as well as their current shortcomings and limitations. \n\n\n\n \n\n\n\n\n\n\n\nHost: Joëlle Rüegg joelle.ruegg@ebc.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-tobias-andermann/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240129T151500 DTEND;TZID=Europe/Stockholm:20240129T161500 DTSTAMP:20260511T004504 CREATED:20240109T110554Z LAST-MODIFIED:20240109T135707Z UID:10001101-1706541300-1706544900@www.scilifelab.se SUMMARY:[The Svedberg seminar] - The Impossibility of Whales: somatic evolution across the tree of life DESCRIPTION:Alex Cagan \n\n\n\nAssistant ProfessorUniversity of Cambridge\, UK \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nAlex Cagan is an Assistant Professor at the Departments of Genetics\, Pathology and Veterinary Medicine at the University of Cambridge and affiliate of the Programme for Cancer\, Ageing and Somatic Mutation at the Wellcome Sanger Institute. He obtained his PhD in comparative genomics with Svante Pääbo at the Max Planck Institute for Evolutionary Anthropology before doing a post-doc with Inigo Martincorena at the Wellcome Sanger Institute to develop methods to study somatic evolution. His work focuses on the development and application of methods to study somatic evolutionary processes across species to gain insights into cancer\, ageing and environmental monitoring. Alex is also enthusiastic about science illustration and communication. \n\n\n\n \n\n\n\nThe Impossibility of Whales: somatic evolution across the tree of life\n\n\n\nSomatic mutations accumulate in cells throughout life. They underpin the development of cancer and may contribute to ageing. Studying these mutations in healthy tissues has been challenging due to the difficulty of detecting mutations present in single cells or small clones in a tissue. Recent technical advances are enabling their study\, revealing how cells accumulate mutations at different rates and how clonal expansions of mutant cells colonise tissues. Yet little is known about how these processes operate in non-human species. We performed whole-genome sequencing of 208 intestinal crypts from 56 individuals to study the landscape of somatic mutation across 16 mammalian species. This comparative analysis of somatic mutagenesis shed light on the diversity of mutagenic processes across species\, and on long-standing questions regarding the evolution of somatic mutation rates and their role in cancer and ageing. We are now developing methods to enable the study of somatic evolution across any cell type in any species. These approaches aim to provide insights into the evolutionary origin of somatic mutational processes and the mechanisms that underlie cancer resistance in species where cancer is rare.   \n\n\n\n \n\n\n\n\n\n\n\nHost: Matthew Webster matthew.webster@imbim.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-alex-cagan/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240122T151500 DTEND;TZID=Europe/Stockholm:20240122T161500 DTSTAMP:20260511T004504 CREATED:20231211T083458Z LAST-MODIFIED:20240110T165531Z UID:10001067-1705936500-1705940100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Nucleosomes for all: histone-based chromatin in noneukaryotic organisms DESCRIPTION:Karolin Luger \n\n\n\nProfessor University of Colorado\, USA \n\n\n\nPLEASE NOTE: This seminar will be given both in Uppsala\, BMC at January 22:nd and additionally in Solna at January 23\, 14:00\, George and Eva Klein\, Biomedicum\, Solnavägen 9\, Stockholm \n\n\n\n\n\n\n\nBio\n\n\n\nKarolin Luger is a distinguished professor and the Jennie Smoly Caruthers Endowed Chair of Biochemistry at the University of Colorado in Boulder\, and an investigator for the Howard Hughes Medical Institute. She is recognized for her work on nucleosome structure and interacting proteins. The lab also studies the DNA damage recognition protein PARP1 and its interactions with chromatin\, with the aim of developing novel PARP inhibitors for cancer therapy. The group explores histone-based DNA organization in non-eukaryotic organisms\, to gain insight into the evolutionary origin of the nucleosome. \n\n\n\nLuger was born in Austria and obtained a degree in Biochemistry from the University of Innsbruck. She obtained her Ph.D. in biophysics from the Biocenter Basel\, then moved to a postdoc at the ETH Zuerich in 1990. She started her independent career at Colorado State University in 1999\, and in 2015 moved to the University of Colorado at Boulder. She is a fellow of the Biophysical Society\, a member of the National Academy of Science; the American Academy of Arts and Science; and EMBO. In 2023\, she was awarded the World Laureate Association (WLA) Prize in Life Science or Medicine for her groundbreaking work on nucleosome structure. \n\n\n\n \n\n\n\nNucleosomes for all: histone-based chromatin in noneukaryotic organisms\n\n\n\nAll eukaryotes organize their DNA into nucleosomes\, consisting of an octamer of the four core histone proteins H2A\, H2B\, H3\, and H4\, around which 147 base pairs of DNA are wrapped in two tight superhelical turns. Histones were an early acquisition in eukaryogenesis that allowed for massive genome expansion\, a prerequisite for the complexity observed in modern-day eukaryotes. Histones are the targets of epigenetic modifications through the incorporation of histone variants and histone post-translational modifications\, and require elaborate assembly and remodeling machinery for gene regulation. Who provided the chromatin starter kit to the early eukaryote? Many archaea organize their genomes with single\, non-diversified histones that form slinky-like structures\, without the requirement for additional machinery to assemble and disassemble nucleosomal structures.  A subclass of giant viruses (ancient double-stranded DNA viruses that infect amoebae) also encode their own histones\, and these form meta-stable nucleosome-like structures with distinct features. Unexpectedly\, we recently discovered that histones are sporadically present in the bacterial domain of life. In a stunning reversal of ‘histone logic’\, these small histones encase straight DNA rather than wrapping it around them.  As such\, histones are no longer a prerogative of eukaryotes but appear to be an ancient DNA packaging principle that has adapted to varying constraints in different domains of life. \n\n\n\n \n\n\n\n\n\n\n\nHost: Sebastian Deindl sebastian.deindl@icm.uu.se UU\, Simon Elsässer simon.elsasser@scilifelab.se\, KI URL:https://www.scilifelab.se/event/the-svedberg-seminar-karolin-luger/ LOCATION:BMC Trippelrummet\, Husargatan 3\, entrance C11\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20231218T151500 DTEND;TZID=Europe/Stockholm:20231218T161500 DTSTAMP:20260511T004504 CREATED:20231123T133956Z LAST-MODIFIED:20231123T134046Z UID:10001039-1702912500-1702916100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Describing tissue pathogenesis with spatial technologies DESCRIPTION:Sanja Vickovic \n\n\n\nWallenberg Academy Fellow and SciLifeLab FellowDepartment of Immunology\, Genetics and Pathology at Uppsala University \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nDr. Vickovic is currently a Wallenberg Academy Fellow and SciLifeLab Fellow at the Department of Immunology\, Genetics and Pathology at Uppsala University. Dr. Vickovic received her PhD in Gene Technology from the Royal Institute of Technology in Stockholm. Following her graduate work\, Dr. Vickovic joined the Broad Institute of MIT and Harvard\, Columbia University and the New York Genome Center before continuing in her current role as Assistant Professor at Uppsala University. Dr. Vickovic has extensively worked on pioneering novel spatially resolved transcriptomics and genomics methods that enable massively parallel in situ profiling of intact tissue samples.  \n\n\n\nDescribing tissue pathogenesis with spatial technologies\n\n\n\nAbstract: Spatial and molecular characteristics determine tissue function\, yet high-resolution methods to capture both concurrently are lacking. In recent years\, we developed high-definition spatial transcriptomics and multi-omics technologies\, which captures RNA\, protein information or microbiota from histological tissue sections on spatially barcoded arrays. Today\, I will present how these different technologies were developed and are applied in different biological settings. \n\n\n\n \n\n\n\n\n\n\n\nHost: Ulf Landegren ulf.landegren@igp.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-sanja-vickovic/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20231208T151500 DTEND;TZID=Europe/Stockholm:20231208T161500 DTSTAMP:20260511T004504 CREATED:20231124T084624Z LAST-MODIFIED:20231124T084626Z UID:10001040-1702048500-1702052100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Engineered Salmonella for drug delivery to solid tumors DESCRIPTION:Neil Forbes \n\n\n\nProfessor of Chemical EngineeringUniversity of Massachusetts\, USA \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nNeil Forbes is a Professor of Chemical Engineering at the University of Massachusetts\, Amherst. He is an adjunct member of the Molecular and Cell Biology Program and a member of the Institute for Applied Life Sciences. He received a BS in Chemical Engineering from Case Western Reserve University\, received a PhD in Chemical Engineering from the University of California at Berkeley (with Harvey Blanch and Douglas Clark)\, and was a postdoctoral fellow (with Rakesh Jain) in Radiation Oncology at Harvard Medical School / Massachusetts General Hospital. \n\n\n\nEngineered Salmonella for drug delivery to solid tumors\n\n\n\nAbstract: Engineered bacteria have the potential to overcome the limitations that cause cancer therapies to fail. We have created intracellular delivering Salmonella that accumulate in tumors over healthy tissue and deposit deliver therapeutic payloads directly into the cytoplasm of cancer cells. Bacterial delivery of constitutively active caspase-3 blocks the growth of hepatocellular carcinoma and lung metastases\, and increases survival in mice. Salmonella delivery of an exogenous antigen\, such as from a childhood vaccine\, marks cancer cells as foreign\, and triggers a cytotoxic\, antigen-specific CD8 T cell responses. In mice\, intracellular antigen delivery clears established pancreatic tumors\, increases survival\, and prevents tumor re-implantation by establishing new immunity to intrinsic tumor antigens. This tunable platform could deliver an array of protein drugs to target many hard-to-treat intracellular pathways. As an off-the-shelf therapy\, these bacteria are not dependent on intrinsic tumor characteristics and would be effective for a broad range of cancer patients. \n\n\n\n \n\n\n\n\n\n\n\nHost: Mia Phillipson mia.phillipson@mcb.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-neil-forbes/ LOCATION:BMC Room C4:301\, Husargatan 3\, entrance C1\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20231204T151500 DTEND;TZID=Europe/Stockholm:20231204T161500 DTSTAMP:20260511T004504 CREATED:20231123T132908Z LAST-MODIFIED:20231124T082227Z UID:10001037-1701702900-1701706500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Intersecting population genetics\, stem cell biology\, and cellular genomics to study complex human disease DESCRIPTION:Joseph Powell \n\n\n\nProfessor Garvan Institute of Medical Research\, Sydney Australia \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nProfessor Powell is the Director of Translational Genomics at the Garvan Institute and Director of the UNSW Cellular Genomics Futures Institute. He received his PhD from the University of Edinburgh. Subsequently\, he undertook postdoctoral training with Professor Peter Visscher’s FAA FRS and started his lab in 2016. In 2018\, he was recruited as the inaugural Director of the Garvan-Weizmann Centre for Cellular Genomics and developed a multidisciplinary program in translational genomics research. \n\n\n\n\n\n\n\nAbstract: Genetic variants can contribute to disease in many ways. In complex diseases\, hundreds to thousands of variants independently contribute to disease risk\, and an accumulation of risk alleles – often combined with specific environmental exposures –is required to develop the disease phenotype. The overwhelming evidence showing enrichment of disease-associated variants in regulatory regions suggests that regulation of gene expression is likely a dominant mediator for disease risk. Expression quantitative trait loci (eQTL) analysis links disease risk-SNPs to downstream expression effects. An essential next step is defining the cellular contexts in which disease risk-SNPs affect gene expression levels. This will help better understand the molecular and cellular mechanisms by which disease risk is conferred and inform therapeutic strategies. This talk will cover a body of work on how single-cell sequencing technology can be scaled to enable the type of population genetics studies required to address these biological questions. I will present recent research on how we have resolved how genetic variation acts at the level of individual cells in immune cell and stem cell systems and outline the next steps in translating these findings into clinical impact. \n\n\n\n \n\n\n\n\n\n\n\nHost: Weronica Ek\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-joseph-powell/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT END:VCALENDAR