BEGIN:VCALENDAR VERSION:2.0 PRODID:-//SciLifeLab - ECPv6.15.20//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:https://www.scilifelab.se X-WR-CALDESC:Events for SciLifeLab REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20220327T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20221030T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20230326T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20231029T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20250330T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20251026T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20260329T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20261025T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250908T151500 DTEND;TZID=Europe/Stockholm:20250908T161500 DTSTAMP:20260511T013702 CREATED:20250822T070029Z LAST-MODIFIED:20250908T132850Z UID:10001586-1757344500-1757348100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Liquid Biopsy: From Discovery to Clinical Application DESCRIPTION:Catherine Alix-Panabières \n\n\n\nProfessor of OncologyUniversity Medical Center of Montpellier\, France \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\n\n\n\n\nCatherine Alix-Panabières is a Professor of Oncology and the Director of the ‘Laboratoire de Cellules Circulantes Humaines Rares et Biopsie Liquide’ (LCCRH) at Montpellier University Hospital and the Faculty of Medicine. Since 2022\, she has also held the position of Professor at the University of Hamburg in Germany. A specialist in circulating tumor cell (CTC) research for 26 years\, she is credited with coining the term “liquid biopsy” in 2010\, in collaboration with Prof. Pantel. Professor Alix-Panabières instructs students in this subject at academic institutions in France and abroad\, has organized numerous international conferences\, has published over 165 scientific articles and numerous chapters in books and encyclopedias\, has filed three patents and has collaborated on numerous European\, American\, and Asian research projects. Her most significant contribution is the demonstration of the clinical utility of CTCs in breast cancer. She has been the recipient of numerous accolades in France and abroad\, including the “Gallet et Breton” prize in 2012 and the “Berthe Péan\, Antoine et Claude Béclère” prize in 2023\, bestowed by the Académie Nationale de Médecine. In 2022\, she played a pivotal role in the cancer exhibition at the Cité des Sciences et de l’Industrie (Paris)\, which was curated by the National Institute of Cancer (INCa). Furthermore\, the esteemed journal Nature\, in its December 2020 issue\, acknowledged the significance of liquid biopsy as a pivotal advancement in cancer research over the past two decades and showcased the contributions of Prof. Alix-Panabières throughout her career. \n\n\n\n \n\n\n\nLiquid Biopsy: From Discovery to Clinical Application\n\n\n\nThis lecture explores how circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have transformed cancer research and clinical care. I will provide an overview of current technologies for detecting these biomarkers\, detailing their biology and their role in real-time monitoring of cancer progression. Advances now enable genomic\, transcriptomic\, and proteomic profiling of CTCs\, as well as functional studies using patient-derived cell lines. Likewise\, ctDNA offers a non-invasive method to track tumor evolution and minimal residual disease. The lecture will highlight how CTC and ctDNA analyses have deepened our understanding of metastasis and therapy response. Expanding the definition of liquid biopsy to include tumor-induced immune components—such as immune cells\, cytokines\, and interleukins—could offer a more comprehensive view\, particularly in the context of immunotherapy. I will conclude by discussing how CTC and ctDNA research uncovers mechanisms of immune escape and may guide the development of innovative strategies to improve cancer treatment. \n\n\n\nHost: Masood Kamali-Moghaddam masood.kamali@igp.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-catherine-alix-panabieres/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250512T151500 DTEND;TZID=Europe/Stockholm:20250512T161500 DTSTAMP:20260511T013702 CREATED:20250423T092440Z LAST-MODIFIED:20250424T080516Z UID:10001534-1747062900-1747066500@www.scilifelab.se SUMMARY:[The Svedberg seminar] Extracting meaning from high-throughput functional genomics data with Bayesian statistics DESCRIPTION:High-throughput functional genomics technologies have transformed infection biology into an increasingly data-driven science\, yet extracting meaningful insights from complex experiments remains challenging. Bayesian hierarchical modeling addresses these challenges by providing a framework to reason about the underlying data generating process. Here\, I illustrate the power of this approach through two case studies. First\, Bayesian modeling of RNA decay dynamics in Salmonella enterica identified confounding factors significantly biasing previous global RNA half-life estimates and revealed novel functions of bacterial RNA-binding proteins via transcriptome-wide differential stability analysis. Second\, we designed and analyzed a genome-wide transposon insertion screen for Shigella flexneri in a realistic human organoid infection model\, accounting for population bottlenecks and uncovering an unexpected role for bacterial tRNA modification enzymes in regulating virulence. I will end with an outlook on scaling our approach to very large datasets in the context of bacterial single-cell RNA-seq. \n\n\n\nLars Barquist\, Assistant Professor University of Toronto\, Canada \n\n\n\nHost: Maria Letizia Di Martino ml.dimartino@imbim.uu.se and Mikael Sellin mikael.sellin@imbim.uu.se \n\n\n\nBio\n\n\n\nLars received his PhD from Cambridge University for work on high-throughput and computational methods for studying pathogen evolution at the Wellcome Sanger Institute. After an Alexander von Humboldt postdoctoral fellowship\, he went on to start his own research group in 2018 at the Helmholtz Institute for RNA-based Infection Research in Würzburg\, Germany before recently moving to the University of Toronto. His work spans a broad range of topics at the interface of infection and computational biology\, ranging from large-scale comparative pathogen genomics and genotype-to-phenotype inference to detailed molecular studies of regulatory mechanisms and translational applications in antibiotic development. URL:https://www.scilifelab.se/event/the-svedberg-seminar-lars-barquist/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250422T151500 DTEND;TZID=Europe/Stockholm:20250422T161500 DTSTAMP:20260511T013702 CREATED:20250409T070149Z LAST-MODIFIED:20250409T070826Z UID:10001525-1745334900-1745338500@www.scilifelab.se SUMMARY:[The Svedberg seminar]-The origins and functional evolution of amniote sex chromosomes DESCRIPTION:Henrik Kaessmann \n\n\n\nProfessor of Evolutionary Genomics at Heidelberg \, Germany \n\n\n\nBio\n\n\n\nDr. Henrik Kaessmann is Professor of Evolutionary Genomics at Heidelberg University. His research focuses on the molecular foundations of mammalian phenotypic evolution\, leveraging various comparative and functional genomics approaches. After earning his Ph.D. at the Max Planck Institute for Evolutionary Anthropology\, he conducted postdoctoral research at the University of Chicago as an EMBO Fellow. His interdisciplinary lab\, which he initially established in Lausanne (Switzerland)\, has pioneered large-scale studies of gene expression changes and their phenotypic implications across various biological dimensions\, including organs\, species\, developmental stages\, gene expression layers\, coding and noncoding gene types\, splicing isoforms\, and sexes. Prof. Kaessmann has published extensively in leading journals and has received numerous prestigious honors\, including three ERC grants\, EMBO membership\, the Friedrich Miescher Award\, and the Cloëtta Prize. Beyond his research\, he teaches and mentors at Heidelberg University and maintains active collaborations with clinical researchers and major scientific institutions worldwide.Collectively\, Henrik Kaessmann’s transformative work has profoundly advanced our understanding of the molecular foundations of mammalian phenotypic evolution and the driving forces of natural selection. The remarkable scope of his lab‘s major findings demonstrates how large-scale genomics approaches can yield fundamental biological insights and test key hypotheses. Notably\, his interdisciplinary research has had far-reaching impact beyond evolution and development\, as evidenced by extensive citations across diverse fields. His findings\, including the observation of functional divergence of many genes between humans and mice\, and unique gene expression (i.e.\, transcriptome\, epigenome\, translatome) datasets  spanning key organs and developmental stages in humans and various model and non-model species\, have become indispensable resources for biomedical research in general. To maximize their impact\, his team has created interactive public databases that ensure optimal usability for the scientific community. \n\n\n\n \n\n\n\nThe origins and functional evolution of amniote sex chromosomes\n\n\n\n In our lab\, we carry out large-scale studies of gene expression changes and their phenotypic implications across various biological dimensions (e.g.\, species\, organs\, developmental stages\, gene expression layers\, coding and noncoding gene types\, splicing isoforms\, and sexes). In this seminar\, I will focus on our endeavors to unravel the origins of the different amniote sex chromosome systems\, which emerged from ancestral sets of autosomes. We have\, for example\, unveiled the origins of the sex chromosomes of therian (i.e.\, placental and marsupial) and monotreme mammals\, and those of birds and lizards. We then scrutinized the evolutionary and functional consequences of sex chromosome differentiations (i.e.\, the degeneration of Y or W chromosomes in males or females\, respectively) and the associated selective forces. Overall\, our work has illuminated the evolution of the specific gene contents on the respective sex chromosomes\, the origins and consequences of male (meiotic) sex chromosome inactivation\, and the forces and mechanisms underlying the evolution of the various amniote dosage compensation mechanisms\, including the drivers underlying the emergence of the female X inactivation mechanism in therians. I will present published and unpublished highlights of our work \n\n\n\nHost: Leif Andersson leif.andersson@imbim.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-henrik-kaessmann/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250407T151500 DTEND;TZID=Europe/Stockholm:20250407T161500 DTSTAMP:20260511T013702 CREATED:20250324T130645Z LAST-MODIFIED:20250324T130745Z UID:10001512-1744038900-1744042500@www.scilifelab.se SUMMARY:[The Svedberg seminar]-Navigating Lipid Metabolism:  From Basic Molecular Mechanisms to Cellular Symphony DESCRIPTION:Aditi Das\n\n\n\nProfessor School of Chemistry and Biochemistry Georgia Institute of Technology\, USA \n\n\n\nBio\n\n\n\nDr. Aditi Das is a Professor in the School of Chemistry and Biochemistry at Georgia Institute of Technology (Georgia Tech). Her research explores lipid biochemistry\, enzymology\, and drug metabolism\, with a focus on bioactive metabolites and their roles in inflammation and neurodegenerative diseases. She earned her Ph.D. in chemistry from Princeton University\, specializing in functional protein design\, followed by postdoctoral research utilizing biophysical tools to study membrane proteins in Nanodiscs. Dr. Das has made significant contributions to understanding cytochrome P450 enzymes and their role in lipid oxidation\, leading to advances in drug discovery and biomedical applications. Her work has been widely published in high-impact journals\, and she has received numerous grants and awards. Her national accolades include the NIH R35 Outstanding Researcher Award\, the E.L.R. Stokstad Award\, and the Mary Swartz Rose Young Investigator Award from the American Society for Nutrition. Beyond her research\, she serves on the Editorial Advisory Boards of Molecular Pharmacology and Frontiers in Pharmacology. Through her work\, Dr. Das continues to advance the fields of lipid biochemistry and cannabinoid metabolism\, translating fundamental science into real-world applications for human health. \n\n\n\n \n\n\n\nNavigating Lipid Metabolism:  From Basic Molecular Mechanisms to Cellular Symphony\n\n\n\nLipids are vital for cellular functions\, acting as structural components\, signaling molecules\, and energy sources. Their metabolism\, particularly through cytochrome P450s and other oxidizing enzymes\, plays a key role in inflammation and disease. This study uses biochemical\, analytical\, and biophysical methods to examine the metabolism of endocannabinoids and cannabinoids by membrane-bound cytochrome P450s\, stabilized in nanoscale lipid bilayers (Nanodiscs). The pharmacological properties of lipid metabolites are evaluated\, focusing on their impact on inflammation and pain receptor modulation. The study also explores the metabolism of minor cannabinoids like cannabinol (CBN)\, cannabigerol (CBG)\, and cannabichromene (CBC)\, which provide medicinal benefits without THC’s psychoactive effects. Computational modeling helps further understand binding mechanisms\, and in vitro studies confirm the bioactivity of these metabolites. This integrated approach enhances our understanding of lipid metabolism and cannabinoid pharmacology\, supporting the development of therapeutic strategies for pain and inflammatory diseases. \n\n\n\nHost: Peter Kasson peter.kasson@icm.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-aditi-das/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250310T151500 DTEND;TZID=Europe/Stockholm:20250310T161500 DTSTAMP:20260511T013702 CREATED:20250123T150313Z LAST-MODIFIED:20250210T141539Z UID:10001461-1741619700-1741623300@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Human beta cell protection by Nature DESCRIPTION:Bart RoepProfessorLeiden University Medical Center\, Netherlands \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nBart Roep is Professor of Medicine & Professor of Diabetology\, Immunopathology and Intervention at the Department of Internal Medicine\, Leiden University Medical Center\, Leiden\, Netherlands\, where he heads the Section Immuno-modulation & Regenerative Medicine. He studied Medicine and Life Sciences at the University of Amsterdam and obtained his PhD in Medicine at Leiden University. He pioneered studies on the role of T-cells in the pathogenesis of T1D and discovered some of their targets in β-cells\, provided seminal proof of their role in human β-cell destruction and defined immune correlates of disease progression and therapeutic intervention. He contributed to a suite of clinical intervention trials in T1D\, including pioneering strategies on tissue-specific tolerance induction\, regenerative medicine\, gene and stem cell therapy\, faecal microbiome transplantation and β-cell replacement therapies (pancreatic donor islets and embryonic stem cell derived β-cell progenitors). A profound twist in prevalent belief of the immunopathogenesis involved his discovery of the role of β-cells in their own demise. His current focus is on regenerative medicine in T1D from an immunological perspective. \n\n\n\nHuman beta cell protection by Nature\n\n\n\nType 1 diabetes results from an autoimmune mediated destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans in people with genetic predisposition to develop this disease. Insulin gene (INS) variation and beta-cell stress associate with risk for development of type 1 diabetes  (T1D) and autoimmunity against insulin. We discovered the relationship between ER stress and insulin mRNA from INS risk variants in human β-cells\, and how this variation relates to β-cells function\, stress and immunogenicity. This novel explanation for genetic protection from T1D inferred by INS polymorphism\, puts β-cells in the center of T1D pathogenesis. Beta cells carrying this particular protective INSP variant can alleviate ER stress by insulin mRNA decay\, resulting in reduced immunogenicity and improved islet function. We propose that INSP is a causal variant contributing to genetic protection from T1D. The clinical and therapeutic implications of this discovery will be discussed. \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nHost: Olov Andersson olov.andersson@mcb.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-bart-roep/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250219T151500 DTEND;TZID=Europe/Stockholm:20250219T161500 DTSTAMP:20260511T013702 CREATED:20250210T171944Z LAST-MODIFIED:20250211T101304Z UID:10001484-1739978100-1739981700@www.scilifelab.se SUMMARY:[The Svedberg seminar]-Imaging the molecular processes of cell division across scale DESCRIPTION:Jan EllenbergProfessor Karolinska Institutet Stockholm\, Sweden and European Molecular Biology Laboratory\, Heidelberg\, Germany Director\, Science for Life Laboratory\, Sweden \n\n\n\n \n\n\n\nTHE LENNART PHILIPSON MEMORIAL LECTURE2025 \n\n\n\nLecture hall A1:107a\, BMC\, Uppsala University Wednesday\, February 19\, 2025 at 3:15 pm   \n\n\n\nBio \n\n\n\nProf. Jan Ellenberg Professor Ellenberg is renowned for his groundbreaking research in cell biology\, particularly in the areas of advanced imaging and the study of cell division. His approach of the so-called 4D dynamic change of molecular structures in living cells\, studied in individual\, and all the way into cells\, embedded in organismal tissues has generated new insight and opened immense technological potential. Dr. Ellenberg has been a group leader at the European Molecular Biology Laboratory (EMBL) since 1999\, the head of the Gene Expression Unit between 2006-2010 and the head of the Cell Biology and Biophysics Unit since 2010. He has been coordinating infrastructure development within EMBL and at the European level. Since July 2024\, Dr. Ellenberg has been acting as the Director of SciLifeLab in Sweden\, became Professor at Karolinska Institutet and an Affiliated Professor at Stockholm University and KTH Royal Institute of Technology. A single (!) representative publication out of the long series of top articles published by Ellenberg and his group highlights the essence of this year’s Lennart Philipson Memorial lecture: Gerlich D\, Ellenberg J. 4D imaging to assay complex dynamics in live specimens. Nat Cell Biol. 2003; Suppl: S14-9. Welcome! URL:https://www.scilifelab.se/event/the-svedberg-seminar-jan-ellenberg/ LOCATION:BMC Lecture hall A1:107a\, BMC\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20250210T151500 DTEND;TZID=Europe/Stockholm:20250210T161500 DTSTAMP:20260511T013702 CREATED:20250121T074231Z LAST-MODIFIED:20250210T140803Z UID:10001456-1739200500-1739204100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - On giant lungfish genomes and the genomics of adaptations and speciation in hyperdiverse cichlid fish radiations DESCRIPTION:Axel MeyerProfessorUniversity of Konstanz\, Germany \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nAxel Meyer (*1960 in Lübeck) studied biology at the Universities of Marburg and Kiel in Germany before he moved to the USA in 1982. At the University of California he received his Master (1985) and PhD (1988) degrees in Berkeley’s Department of Zoology. For the last year of his PhD he worked in the Biochemistry Department in lab of Allan C. Wilson at Berkeley. There he was part of a team that was the first to use PCR for questions in molecular evolution\, phylogenetics\, and ancient DNA. As an Alfred P. Sloan Postdoc he continued to work with Allan Wilson in the Biochemistry Department at Berkeley until 1990 when he became an Assistant and then (since 1993) Associate Professor in the Ecology and Evolution Department at Stony Brook\, NY. In 1997 he returned to Germany as Chair in Zoology and Evolutionary Biology at the University of Konstanz. He is a member of several academies\, including EMBO\, the Academia Europaea\, the Berlin Academy of Sciences\, the German National Academy Leopoldina\, and The American Academy of Arts and Sciences  and received a numerous awards and fellowships including Fulbright and Guggenheim Fellowships\, the Carus Medal of the Leopoldina\, and a Hector Prize. Axel Meyer’s research focuses on fundamental questions in evolutionary biology and comparative genomics with a focus on speciation\, Hox genes\, genomics of adaptations\, and gene and genome duplications. He was among the first to confirm Susumo Ohno’s suggestion that all modern fishes are derived from a lineage that experienced an additional (the teleost-specific genome duplication\, TSGD) genome duplication. Meyer received the EMBO award for communications in the life sciences for his efforts to communicate science to the public. He has a science podcast for Cicero Magazin\, wrote a popular science book on the biology of men and women\, and had a weekly column for the financial newspaper Handelsblatt. Besides Konstanz he is affiliated with the SCSIO in Guangzhou and the Museum of Comparative Zoology at Harvard University \n\n\n\nOn giant lungfish genomes and the genomics of adaptations and speciation in hyperdiverse cichlid fish radiations\n\n\n\nLungfishes are the closest living relatives to tetrapods among the “fishes”. Their genomes are the largest animal genomes\, composed of over 90% repetitive DNA\, and their size\, 3-15x larger than the human genome (~45-92Gb)\, makes them difficult to assemble and interpret. The analyses of these genomes revealed the genetics of some pre-adaptations (respiration\, locomotion\, nitrogen excretion\, olfaction) that might have permitted their relatives to conquer land in the Devonian and to give rise to all land vertebrates. While lungfishes are ancient “living fossils” that appear not have changed for >100 Million years\, the cichlid fishes of the East African Great lakes and of Nicaragua’s crater lakes have speciated and morphologically diversified at record speeds. New species formed within a few hundred generations and several phenotypic innovations evolved repeatedly and due to structural variants and transposable element activity. \n\n\n\n \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\nHost: Dan Larhammar dan.larhammar@uu.se\, Per Ahlberg Per.Ahlberg@ebc.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-axel-meyer/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240603T151500 DTEND;TZID=Europe/Stockholm:20240603T161500 DTSTAMP:20260511T013702 CREATED:20240503T152931Z LAST-MODIFIED:20240503T152932Z UID:10001253-1717427700-1717431300@www.scilifelab.se SUMMARY:[The Svedberg seminar] Combining artificial intelligence approaches and cellular screens to define functional regulatory variation in mammalian genomes DESCRIPTION:James Prendergast \n\n\n\nProfessorRoslin Institute\, University of Edinburgh- UK \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nJames Prendergast is professor of bioinformatics at the Roslin Institute in Edinburgh. His academic journey began with a focus on the genetics of colorectal cancer during the early days of genome-wide association studies\, leading to a PhD in Bioinformatics and Statistical Genetics from the University of Edinburgh in 2007. \n\n\n\nAfter completing his PhD\, James held post-doctoral positions at the European Bioinformatics Institute and University College Dublin\, before joining the Human Genetics Unit at the University of Edinburgh. In 2013\, he transitioned to livestock research\, first joining the Roslin Institute on a career-track fellowship. \n\n\n\nThrough his career\, James has been part of several international consortia\, including the FAANG BovReg project\, Bridget\, FANTOM\, and the Bovine Pangenome Consortium. These collaborations have allowed him to continue to work across both human and livestock genetics research. \n\n\n\n \n\n\n\nCombining artificial intelligence approaches and cellular screens to define functional regulatory variation in mammalian genomes\n\n\n\n \n\n\n\nDespite significant progress\, the exact genetic variants that influence crucial mammalian traits and phenotypes often remain unknown. This uncertainty presents a significant challenge to the enhancement of livestock health and production through cutting-edge genomic approaches like genome editing. While predicting functional coding variants is comparatively straightforward\, it is suggested that regulatory variants are the primary drivers of phenotypic differences between individuals. In this talk\, I will delve into our efforts to bridge this knowledge gap by integrating novel cellular screen datasets and AI workflows to predict functional regulatory variants in mammalian genomes. This includes the pioneering application of the Survey of Regulatory Elements (SuRE) approach to cattle\, where we have scrutinized the regulatory impact of tens of millions of cattle variants\, while effectively eliminating the confounding effect of linkage disequilibrium that hampers other methodologies. I will demonstrate how these strategies can not only effectively prioritize regulatory variants in both humans and cattle\, but also identify those variants associated with significant phenotypes in each species. \n\n\n\n \n\n\n\n\n\n\n\n Host: Gabriella Lindgren\, SLU and Jennifer Meadows\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-james-prendergast/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240522T151500 DTEND;TZID=Europe/Stockholm:20240522T161500 DTSTAMP:20260511T013702 CREATED:20240503T151406Z LAST-MODIFIED:20240503T151408Z UID:10001252-1716390900-1716394500@www.scilifelab.se SUMMARY:[The Svedberg seminar] Mechanisms of Transcriptional Regulation of Drosophila & Mammalian Genomes DESCRIPTION:John Lis \n\n\n\nProfessor of Molecular Biology and GeneticsCornell University\, USA \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nDr\, Lis received his B.S degree in Chemistry from Fairfield University\, and his Ph.D. in Biochemistry from Brandeis University. His postdoctoral work at Stanford University focused on molecular genetics and was supported by a Helen Hay Whitney Foundation Fellowship. Dr. Lis joined the faculty at Cornell in 1978 and served as Chairman of the Section of Biochemistry\, Molecular & Cell Biology in the 1990s. He is now the Barbara McClintock Professor of Molecular Biology and Genetics and a member of the American Academy of Arts and Sciences and the National Academy of Sciences. Dr. Lis’ group develops new approaches to study the molecular mechanisms of transcription regulation\, and he uses these newly developed and existing technologies in both focused studies of highly-regulated genes and in comprehensive analyses of gene regulation of Drosophila and human genomes. A Harvey Lecture at Rockefeller University summarizes some of his past work that can be accessed using the following link. https://harveysociety.org/videos/video.php?series=114&lecture=1&wvideo=7810nzrdc0 \n\n\n\n \n\n\n\nMechanisms of Transcriptional Regulation of Drosophila & Mammalian Genomes \n\n\n\nTranscription by RNA Polymerase II (Pol II)\, the enzyme responsible for all mRNA synthesis\, is highly regulated by protein factors at multiple steps in the transcription cycle. Two critical regulatory steps\, whose regulatory integration is critical for the sophisticated gene regulation seen in multicellular eukaryotes\, are 1) the recruitment of Pol II to promoters where it rapidly initiates transcription and can enter into a promoter-proximal\, paused state 20-50 base pairs from the initiation site; and 2) the release of paused Pol II into productive elongation. Promoter-proximal pausing is dependent on protein complexes DSIF (DRB Sensitivity Inducing Factor) and NELF (Negative Elongation Factor) bind to Pol II early in transcription to stabilize pausing. Pause release occurs upon phosphorylation of Pol II\, DSIF and NELF by the Cdk9\, Cyclin T1 heterodimer P-TEFb (Positive Transcription Elongation Factor b). Several elongation factors\, e.g.\, PAF1 and Spt6\, engage with Pol II in its transition from its promoter-proximal pause to productive elongation. Although Pol II pausing is a key step in transcription regulation and has been extensively studied\, the molecular mechanisms of pausing and pause release to productive elongation are far from being completely understood. Furthermore\, recent studies have led to competing molecular mechanisms on the role of promoter-proximal pausing in the control of transcription. In this seminar\, I will describe the evolution of our understanding of transcription regulation as well as describe our latest efforts to advance and resolve this understanding using a variety of state-of-the-art genomic and optical methods in Drosophila and mammals \n\n\n\n \n\n\n\n\n\n\n\nHost: Anniina Vihervaara anniina.vihervaara@scilifelab.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-john-lis/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240520T151500 DTEND;TZID=Europe/Stockholm:20240520T161500 DTSTAMP:20260511T013702 CREATED:20240409T150428Z LAST-MODIFIED:20240409T150428Z UID:10001213-1716218100-1716221700@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Multilevel drift and selection in the evolution of prokaryotic plasmids DESCRIPTION:Tal Dagan \n\n\n\nProfessorInstitute of general microbiology\, Kiel University\, Germany. \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nProf. Tal Dagan graduated her PhD in 2005 and moved to Germany for her postdoctoral studies. Since 2013 she is a professor of microbiology at Kiel University. Her main research interest is microbial genome evolution via lateral gene transfer with a focus on the evolution of prokaryotic plasmids \n\n\n\n \n\n\n\nMultilevel drift and selection in the evolution of prokaryotic plasmids\n\n\n\nPlasmids are an extrachromosomal genetic elements that populate prokaryote cells. Due to their interaction with a hosting cell\, drift and selection operate on plasmid alleles at two hierarchical levels: the collective of plasmids within the host and the collective of cells within the host population. The effect of these two levels on plasmid evolution remains understudied. Using experimental evolution approach integrated with phylogenomic reconstruction we found that: i) drift and selection at the level of the host population leads to contrasting effects on the plasmid fitness and ii) segregational drift of plasmid alleles during cell division constrains the rate of plasmid evolution. Our findings may apply for the evolution of other extrachromosomal genetic elements having a similar population structure. Focusing on plasmids\, our research thus uncovers general principles in the evolution of autonomously replicating genetic elements. \n\n\n\n \n\n\n\n\n\n\n\nHost: Maliheh Mehrshad maliheh.mehrshad@slu.se\, SLU and Helen Wang helen.wang@imbim.uu.se UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-tal-dagan/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240506T151500 DTEND;TZID=Europe/Stockholm:20240506T161500 DTSTAMP:20260511T013702 CREATED:20240409T150217Z LAST-MODIFIED:20240411T124823Z UID:10001227-1715008500-1715012100@www.scilifelab.se SUMMARY:[The Svedberg seminar] Genetics of Type 2 Diabetes: Advances\, Prospects\, and Challenges DESCRIPTION:Benjamin F. Voight \n\n\n\nAssociate Professor\, Pharmacology and GeneticsUniversity of Pennsylvania – Perelman School of Medicine\, USA \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nBen Voight received his PhD from the University of Chicago\, with postdoctoral training at Massachusetts General Hospital\, staying on at the Broad Institute as a research scientist. He is currently an Associate Professor at the University of Pennsylvania in the Department of Systems Pharmacology and Translational Therapeutics\, and the Department of Genetics. As a human geneticist\, research from his group focuses on understanding the genetic\, biological\, and evolutionary basis of metabolic phenotypes in human populations\, particularly diabetes\, cardiovascular\, and liver disease. Recent data scientific efforts focus on new association studies for discovery using biobank-scale data (e.g.\, the Million Veteran Program)\, post-association study analyses to understand the genetic architecture of disease and ultimately the underlying causal variants\, and quantitative trait locus mapping for expression and chromatic accessibility using primary pancreas and liver data sets. \n\n\n\n \n\n\n\nGenetics of Type 2 Diabetes: Advances\, Prospects\, and Challenges\n\n\n\n \n\n\n\nType 2 diabetes is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms. Elucidating the processes and mechanisms by identifying new loci associated with disease\, the underlying causal variants and genes\, and the cell types of action are areas of current focus by the research community. I will describe recent contributions by the Type 2 Diabetes Global Genomic Initiative\, our newly minted consortium focused on expanding locus discovery across diverse ancestries\, understanding physiological mechanism and prediction of susceptibility to complications through genetic subtyping\, and nomination of putative causal genes and mechanism through statistical colocalization. I will also briefly discuss prospects for exciting potential advances in the near term from new data types and improved computational methods\, as well as my perceptions of open challenges and potential thoughts on how to take those on – ultimately to understand disease etiology and to generate prospects for therapeutic intervention. \n\n\n\n \n\n\n\n\n\n\n\nHost: Marcel den Hoed marcel.den_hoed@igp.uu.se UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-benjamin-voight/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240408T151500 DTEND;TZID=Europe/Stockholm:20240408T161500 DTSTAMP:20260511T013702 CREATED:20240326T080916Z LAST-MODIFIED:20240327T160812Z UID:10001212-1712589300-1712592900@www.scilifelab.se SUMMARY:Extracellular vesicles in cancer therapy-role of checkpoint molecules DESCRIPTION:Susanne Gabrielsson \n\n\n\nProfessorKarolinska Institutet \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nProf. Gabrielsson has after her PhD at Stockholm University and a postdoc at the Curie Institute in Paris\, established a group dedicated to extracellular vesicle (EV)/exosome research at the Karolinska Institutet. She has been a pioneer in the field of immune effects of exosomes. Dr. Gabrielsson was the first to describe the presence of exosomes in bronchoalveolar lavage fluid\, as well as in breast milk. Her work has revealed that EVs are major players in lung diseases such as asthma and sarcoidosis\, where they contribute to inflammation. Her studies in animal models give new insights into how EV based therapies can be optimized for immunotherapeutic applications in cancer. \n\n\n\n \n\n\n\nExtracellular vesicles in cancer therapy-role of checkpoint molecules\n\n\n\n \n\n\n\nThe talk will focus on their work to use EVs for cancer therapy. They lately showed that EVs can induce response to checkpoint inhibitors in a treatment refractory model (Veerman et al\, 2023)\, and they are now investigating the role of PD-1 and PD-L1 on EVs by investigating immune responses to EVs from PD-1 and PD-L1 KO mice. \n\n\n\n \n\n\n\n\n\n\n\nHost: Masood Kamali-Moghaddam masood.kamali@igp.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-susanne-gabrielsson/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240226T151500 DTEND;TZID=Europe/Stockholm:20240226T161500 DTSTAMP:20260511T013702 CREATED:20240207T162516Z LAST-MODIFIED:20240207T162519Z UID:10001149-1708960500-1708964100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Spatial biodiversity modeling with remote sensing and AI DESCRIPTION:Tobias Andermann \n\n\n\nAssistant Professor\, DDLS fellowUppsala University \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nTobias Andermann is a biodiversity researcher dedicated to providing data and computatio- nal tools for combating the global biodiversity crisis. His group\, the Biodiversity Data Lab\, is working on the intersection of molecular biology\, spatial ecology\, and machine learning\, with the mission to provide a more comprehensive view on the distribution of biodiversity\, including hidden diversity of inconspicuous and even undescribed species through the use of environmental DNA. \n\n\n\n \n\n\n\nSpatial biodiversity modeling with remote sensing and AI\n\n\n\nThere is an ever-increasing need for developing standardized ways of quantifying the biodiversity value of a site. This need arises from international and local policies (e.g. the COP15 UN Biodiversity agreement) as well as from the independent investments of companies world-wide in developing biodiversity-positive profiles\, motivated by their public perception. This momentum provides an unprecedented opportunity to efficiently protect biodiversity on a large scale to turn around the alarmingly negative biodiversity trends of the recent decades and centuries. While individual biodiversity assessments for specific sites can be done through targeted inventories\, either through taxonomic experts or increasingly through the use of environmental DNA\, we also need ways of scaling up such biodiversity evaluations to larger scales\, covering entire regions or countries. AI models provide a unique tool to leverage complex biodiversity and remote sensing data to make predictions of biodiversity on large spatial scales\, while at the same time providing high spatial resolution. In this talk I will present some of these models from my ongoing research and discuss their utility\, as well as their current shortcomings and limitations. \n\n\n\n \n\n\n\n\n\n\n\nHost: Joëlle Rüegg joelle.ruegg@ebc.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-tobias-andermann/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240129T151500 DTEND;TZID=Europe/Stockholm:20240129T161500 DTSTAMP:20260511T013702 CREATED:20240109T110554Z LAST-MODIFIED:20240109T135707Z UID:10001101-1706541300-1706544900@www.scilifelab.se SUMMARY:[The Svedberg seminar] - The Impossibility of Whales: somatic evolution across the tree of life DESCRIPTION:Alex Cagan \n\n\n\nAssistant ProfessorUniversity of Cambridge\, UK \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nAlex Cagan is an Assistant Professor at the Departments of Genetics\, Pathology and Veterinary Medicine at the University of Cambridge and affiliate of the Programme for Cancer\, Ageing and Somatic Mutation at the Wellcome Sanger Institute. He obtained his PhD in comparative genomics with Svante Pääbo at the Max Planck Institute for Evolutionary Anthropology before doing a post-doc with Inigo Martincorena at the Wellcome Sanger Institute to develop methods to study somatic evolution. His work focuses on the development and application of methods to study somatic evolutionary processes across species to gain insights into cancer\, ageing and environmental monitoring. Alex is also enthusiastic about science illustration and communication. \n\n\n\n \n\n\n\nThe Impossibility of Whales: somatic evolution across the tree of life\n\n\n\nSomatic mutations accumulate in cells throughout life. They underpin the development of cancer and may contribute to ageing. Studying these mutations in healthy tissues has been challenging due to the difficulty of detecting mutations present in single cells or small clones in a tissue. Recent technical advances are enabling their study\, revealing how cells accumulate mutations at different rates and how clonal expansions of mutant cells colonise tissues. Yet little is known about how these processes operate in non-human species. We performed whole-genome sequencing of 208 intestinal crypts from 56 individuals to study the landscape of somatic mutation across 16 mammalian species. This comparative analysis of somatic mutagenesis shed light on the diversity of mutagenic processes across species\, and on long-standing questions regarding the evolution of somatic mutation rates and their role in cancer and ageing. We are now developing methods to enable the study of somatic evolution across any cell type in any species. These approaches aim to provide insights into the evolutionary origin of somatic mutational processes and the mechanisms that underlie cancer resistance in species where cancer is rare.   \n\n\n\n \n\n\n\n\n\n\n\nHost: Matthew Webster matthew.webster@imbim.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-alex-cagan/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20240122T151500 DTEND;TZID=Europe/Stockholm:20240122T161500 DTSTAMP:20260511T013702 CREATED:20231211T083458Z LAST-MODIFIED:20240110T165531Z UID:10001067-1705936500-1705940100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Nucleosomes for all: histone-based chromatin in noneukaryotic organisms DESCRIPTION:Karolin Luger \n\n\n\nProfessor University of Colorado\, USA \n\n\n\nPLEASE NOTE: This seminar will be given both in Uppsala\, BMC at January 22:nd and additionally in Solna at January 23\, 14:00\, George and Eva Klein\, Biomedicum\, Solnavägen 9\, Stockholm \n\n\n\n\n\n\n\nBio\n\n\n\nKarolin Luger is a distinguished professor and the Jennie Smoly Caruthers Endowed Chair of Biochemistry at the University of Colorado in Boulder\, and an investigator for the Howard Hughes Medical Institute. She is recognized for her work on nucleosome structure and interacting proteins. The lab also studies the DNA damage recognition protein PARP1 and its interactions with chromatin\, with the aim of developing novel PARP inhibitors for cancer therapy. The group explores histone-based DNA organization in non-eukaryotic organisms\, to gain insight into the evolutionary origin of the nucleosome. \n\n\n\nLuger was born in Austria and obtained a degree in Biochemistry from the University of Innsbruck. She obtained her Ph.D. in biophysics from the Biocenter Basel\, then moved to a postdoc at the ETH Zuerich in 1990. She started her independent career at Colorado State University in 1999\, and in 2015 moved to the University of Colorado at Boulder. She is a fellow of the Biophysical Society\, a member of the National Academy of Science; the American Academy of Arts and Science; and EMBO. In 2023\, she was awarded the World Laureate Association (WLA) Prize in Life Science or Medicine for her groundbreaking work on nucleosome structure. \n\n\n\n \n\n\n\nNucleosomes for all: histone-based chromatin in noneukaryotic organisms\n\n\n\nAll eukaryotes organize their DNA into nucleosomes\, consisting of an octamer of the four core histone proteins H2A\, H2B\, H3\, and H4\, around which 147 base pairs of DNA are wrapped in two tight superhelical turns. Histones were an early acquisition in eukaryogenesis that allowed for massive genome expansion\, a prerequisite for the complexity observed in modern-day eukaryotes. Histones are the targets of epigenetic modifications through the incorporation of histone variants and histone post-translational modifications\, and require elaborate assembly and remodeling machinery for gene regulation. Who provided the chromatin starter kit to the early eukaryote? Many archaea organize their genomes with single\, non-diversified histones that form slinky-like structures\, without the requirement for additional machinery to assemble and disassemble nucleosomal structures.  A subclass of giant viruses (ancient double-stranded DNA viruses that infect amoebae) also encode their own histones\, and these form meta-stable nucleosome-like structures with distinct features. Unexpectedly\, we recently discovered that histones are sporadically present in the bacterial domain of life. In a stunning reversal of ‘histone logic’\, these small histones encase straight DNA rather than wrapping it around them.  As such\, histones are no longer a prerogative of eukaryotes but appear to be an ancient DNA packaging principle that has adapted to varying constraints in different domains of life. \n\n\n\n \n\n\n\n\n\n\n\nHost: Sebastian Deindl sebastian.deindl@icm.uu.se UU\, Simon Elsässer simon.elsasser@scilifelab.se\, KI URL:https://www.scilifelab.se/event/the-svedberg-seminar-karolin-luger/ LOCATION:BMC Trippelrummet\, Husargatan 3\, entrance C11\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20231218T151500 DTEND;TZID=Europe/Stockholm:20231218T161500 DTSTAMP:20260511T013702 CREATED:20231123T133956Z LAST-MODIFIED:20231123T134046Z UID:10001039-1702912500-1702916100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Describing tissue pathogenesis with spatial technologies DESCRIPTION:Sanja Vickovic \n\n\n\nWallenberg Academy Fellow and SciLifeLab FellowDepartment of Immunology\, Genetics and Pathology at Uppsala University \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nDr. Vickovic is currently a Wallenberg Academy Fellow and SciLifeLab Fellow at the Department of Immunology\, Genetics and Pathology at Uppsala University. Dr. Vickovic received her PhD in Gene Technology from the Royal Institute of Technology in Stockholm. Following her graduate work\, Dr. Vickovic joined the Broad Institute of MIT and Harvard\, Columbia University and the New York Genome Center before continuing in her current role as Assistant Professor at Uppsala University. Dr. Vickovic has extensively worked on pioneering novel spatially resolved transcriptomics and genomics methods that enable massively parallel in situ profiling of intact tissue samples.  \n\n\n\nDescribing tissue pathogenesis with spatial technologies\n\n\n\nAbstract: Spatial and molecular characteristics determine tissue function\, yet high-resolution methods to capture both concurrently are lacking. In recent years\, we developed high-definition spatial transcriptomics and multi-omics technologies\, which captures RNA\, protein information or microbiota from histological tissue sections on spatially barcoded arrays. Today\, I will present how these different technologies were developed and are applied in different biological settings. \n\n\n\n \n\n\n\n\n\n\n\nHost: Ulf Landegren ulf.landegren@igp.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-sanja-vickovic/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20231208T151500 DTEND;TZID=Europe/Stockholm:20231208T161500 DTSTAMP:20260511T013702 CREATED:20231124T084624Z LAST-MODIFIED:20231124T084626Z UID:10001040-1702048500-1702052100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Engineered Salmonella for drug delivery to solid tumors DESCRIPTION:Neil Forbes \n\n\n\nProfessor of Chemical EngineeringUniversity of Massachusetts\, USA \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nNeil Forbes is a Professor of Chemical Engineering at the University of Massachusetts\, Amherst. He is an adjunct member of the Molecular and Cell Biology Program and a member of the Institute for Applied Life Sciences. He received a BS in Chemical Engineering from Case Western Reserve University\, received a PhD in Chemical Engineering from the University of California at Berkeley (with Harvey Blanch and Douglas Clark)\, and was a postdoctoral fellow (with Rakesh Jain) in Radiation Oncology at Harvard Medical School / Massachusetts General Hospital. \n\n\n\nEngineered Salmonella for drug delivery to solid tumors\n\n\n\nAbstract: Engineered bacteria have the potential to overcome the limitations that cause cancer therapies to fail. We have created intracellular delivering Salmonella that accumulate in tumors over healthy tissue and deposit deliver therapeutic payloads directly into the cytoplasm of cancer cells. Bacterial delivery of constitutively active caspase-3 blocks the growth of hepatocellular carcinoma and lung metastases\, and increases survival in mice. Salmonella delivery of an exogenous antigen\, such as from a childhood vaccine\, marks cancer cells as foreign\, and triggers a cytotoxic\, antigen-specific CD8 T cell responses. In mice\, intracellular antigen delivery clears established pancreatic tumors\, increases survival\, and prevents tumor re-implantation by establishing new immunity to intrinsic tumor antigens. This tunable platform could deliver an array of protein drugs to target many hard-to-treat intracellular pathways. As an off-the-shelf therapy\, these bacteria are not dependent on intrinsic tumor characteristics and would be effective for a broad range of cancer patients. \n\n\n\n \n\n\n\n\n\n\n\nHost: Mia Phillipson mia.phillipson@mcb.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-neil-forbes/ LOCATION:BMC Room C4:301\, Husargatan 3\, entrance C1\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20231204T151500 DTEND;TZID=Europe/Stockholm:20231204T161500 DTSTAMP:20260511T013702 CREATED:20231123T132908Z LAST-MODIFIED:20231124T082227Z UID:10001037-1701702900-1701706500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Intersecting population genetics\, stem cell biology\, and cellular genomics to study complex human disease DESCRIPTION:Joseph Powell \n\n\n\nProfessor Garvan Institute of Medical Research\, Sydney Australia \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nProfessor Powell is the Director of Translational Genomics at the Garvan Institute and Director of the UNSW Cellular Genomics Futures Institute. He received his PhD from the University of Edinburgh. Subsequently\, he undertook postdoctoral training with Professor Peter Visscher’s FAA FRS and started his lab in 2016. In 2018\, he was recruited as the inaugural Director of the Garvan-Weizmann Centre for Cellular Genomics and developed a multidisciplinary program in translational genomics research. \n\n\n\n\n\n\n\nAbstract: Genetic variants can contribute to disease in many ways. In complex diseases\, hundreds to thousands of variants independently contribute to disease risk\, and an accumulation of risk alleles – often combined with specific environmental exposures –is required to develop the disease phenotype. The overwhelming evidence showing enrichment of disease-associated variants in regulatory regions suggests that regulation of gene expression is likely a dominant mediator for disease risk. Expression quantitative trait loci (eQTL) analysis links disease risk-SNPs to downstream expression effects. An essential next step is defining the cellular contexts in which disease risk-SNPs affect gene expression levels. This will help better understand the molecular and cellular mechanisms by which disease risk is conferred and inform therapeutic strategies. This talk will cover a body of work on how single-cell sequencing technology can be scaled to enable the type of population genetics studies required to address these biological questions. I will present recent research on how we have resolved how genetic variation acts at the level of individual cells in immune cell and stem cell systems and outline the next steps in translating these findings into clinical impact. \n\n\n\n \n\n\n\n\n\n\n\nHost: Weronica Ek\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-joseph-powell/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20231127T151500 DTEND;TZID=Europe/Stockholm:20231127T161500 DTSTAMP:20260511T013702 CREATED:20231113T153444Z LAST-MODIFIED:20231113T153447Z UID:10001029-1701098100-1701101700@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Brain-wide hierarchical and multiplexed encoding of behaviour in C. elegans DESCRIPTION:Manuel Zimmer \n\n\n\nProfessor Department of Neuroscience and Developmental Biology\, The University of Vienna \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\n\n\n\n\nManuel Zimmer studied biochemistry at the Free University of Berlin and performed his undergraduate thesis in 1998 on neuromuscular synapse formation with Steve Burden at the Skirball Institute of Biomolecular Medicine\, New York University Medical School\, New York. Afterward\, he moved back to Germany to perform his Ph.D. work with Rüdiger Klein at the European Molecular Biology Laboratory in Heidelberg and the Max Planck Institute of Neurobiology in Munich\, until 2003. Here\, he focused on the molecular mechanisms that wire up the nervous system during development. From 2004 to 2010\, he performed his postdoctoral studies with Cori Bargmann at the University of California\, San Francisco\, and Rockefeller University\, New York. Here\, he developed lab-on-a-chip and calcium-imaging techniques to investigate the chemosensory mechanisms by which animals sense oxygen in the environment. Since 2010\, he has lived in Austria\, where he works as an independent group leader at the Research Institute of Molecular Pathology in Vienna. Dr. Zimmer’s current research is focused on how neuronal network dynamics in the brain of C. elegans arise from sleep to wakefulness to engage in processing the sensory world and to produce competent behaviors\, like foraging and navigation. \n\n\n\n \n\n\n\nBrain-wide hierarchical and multiplexed encoding of behaviour in C. elegans\n\n\n\nLarge-scale neuronal recordings in the brains of different species have revealed brain-wide\, highly coordinated patterns of neuronal activity associated with the animals’ ongoing behaviours. It is not known why behaviour is represented in the brain on such a global scale. In the nematode C. elegans\, the activity of such neuronal populations recorded from immobilised animals was suggested to correlate with brain-wide motor commands orchestrating a major action sequence. Direct confirmation of this conclusion in freely crawling animals has been lacking. I will present unpublished data from a new imaging pipeline to record brain-wide activity at single cell resolution in freely crawling animals performing a variety of motor behaviours.Extending our previous findings\, we observe population-wide neural activity in the form of a structured low-dimensional manifold from which the major motor programmes\, arranged as an action sequence\, can be decoded. However\, the brain-wide activity appears to be much richer than just encoding the identity of the main actions: while all behaviourally relevant neuronal activity patterns we detect in our recordings are modulated by the global population modes\, many individual neurons show multiplexed activity\, i.e. they carry additional residual signals. These can represent a variety of behaviourally relevant information\, such as graded movement metrics\, the animal’s undulatory gate\, or even re-afferent sensation of movement-triggered external signals.In summary\, we discover a brain-wide hierarchical organisation of behaviour in which information about the current slow time-scale behavioural state is broadcast across the brain via a low-dimensional population mode\, providing a context for the encoding of fine-tuned fast movement patterns and even sensory perception. We propose this as an organising principle that may apply to animals with larger brains. \n\n\n\nhttps://neurodevbio.univie.ac.at/zimmer-research/ \n\n\n\n\n\n\n\nHost: Klas Kullander\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-manuel-zimmer/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20231023T151500 DTEND;TZID=Europe/Stockholm:20231023T161500 DTSTAMP:20260511T013702 CREATED:20231006T134540Z LAST-MODIFIED:20231006T140206Z UID:10000993-1698074100-1698077700@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Peptide nucleic acid (PNA)-mediated pretargeting for radionuclide therapy DESCRIPTION:Amelie Karlström \n\n\n\nProfessor of Molecular BiotechnologyDepartment of Protein Science\, KTH \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nAmelie Eriksson Karlström is Professor of Molecular Biotechnology at the Department of Protein Science\, KTH\, where her research group is focused on protein engineering\, affinity technologies and bioconjugation chemistry for diagnostic and therapeutic applications. Amelie Eriksson Karlström has a background in solid phase peptide synthesis methodology from PhD studies at the Department of Neurochemistry and Neurotoxicology at Stockholm University. She did postdoctoral studies at the Scripps Research Institute\, La Jolla\, CA\, working on catalytic antibodies and display technologies with Profs. Richard A. Lerner and Carlos Barbas\, III\, before starting her independent research at KTH \n\n\n\n \n\n\n\nPeptide nucleic acid (PNA)-mediated pretargeting for radionuclide therapy\n\n\n\nTargeted radionuclide therapy utilizes tumor-specific radiolabeled molecules to deliver cytotoxic radiation to tumor cells. To avoid unwanted exposure of non-tumor organs\, a pretargeting strategy can be used\, where the tumor-targeting step is uncoupled from the delivery of the toxic radionuclide. The primary agent is administered first and the secondary\, radiolabeled agent is administered after the primary agent has accumulated in the tumor and cleared from non-tumor tissue. We have developed and evaluated a system for pretargeting based on the high selectivity and high affinity of peptide nucleic acid (PNA) hybridization. We have demonstrated that the PNA-based pretargeting system gives high tumor-to-normal tissue contrast in vivo both using affibody molecules and monoclonal antibodies as the tumor-targeting agents.  \n\n\n\nIn this seminar\, the molecular design and technological aspects of the PNA-based pretargeting system will be discussed. Results from preclinical evaluation of the PNA-based pretargeting strategy will be presented.  \n\n\n\n \n\n\n\n\n\n\n\n\n\n\n\nHost: Abhimanyu Thakur\,UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-amelie-karlstrom/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230925T151500 DTEND;TZID=Europe/Stockholm:20230925T161500 DTSTAMP:20260511T013702 CREATED:20230831T123645Z LAST-MODIFIED:20230901T121318Z UID:10000958-1695654900-1695658500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Targeting Non-Coding RNAs Using Synthetic Small Molecules: Original Targets for Innovative Therapies DESCRIPTION:Dr Maria Duca \n\n\n\nCNRS Research Director\, Université Côte d’Azur\, FranceWebsite: icn.univ-cotedazur.fr/tna \n\n\n\nHost: Duc Duy Vo duc.duy.vo@kemi.uu.se\, UU \n\n\n\nBio\n\n\n\nDr. Maria Duca is head of Targeting of Nucleic Acids research group in the Institute of Chemistry of Nice (Université Côte d’Azur – CNRS). After undergraduate studies in Pharmacy and Medicinal Chemistry (Faculty of Pharmacy\, University of Bologna\, Italy)\, she obtained her PhD in Molecular Biochemistry under the supervision of Dr. Paola B. Arimondo (National Natural History Museum\, Paris\, France) working on topoisomerase II inhibitors. A 2-year post-doctoral training in Sydney Hecht’s lab (Department of Chemistry\, University of Virginia\, USA) allowed her to pursue the study of nucleic acids working on targeted protein mutagenesis. After CNRS recruitment as a Research Scientist in 2008 and promotion to Director of Research in 2022\, her research activities focus on the targeting of non-coding RNAs using synthetic small molecules toward innovative therapeutic approaches for anticancer\, antiviral and antimicrobial applications. She has been awarded the Michel Delalande award from the Académie de Pharmacie as well as national and international grants including H2020 grants. She is Associate Editor for RSC Medicinal Chemistry journal\, chair of the Chemical Biology Initiative of EFMC as well as vice-president of the French medicinal chemistry society. \n\n\n\n \n\n\n\nTargeting Non-Coding RNAs Using Synthetic Small Molecules: Original Targets for Innovative Therapies\n\n\n\nRNA is one of the most intriguing and promising biological targets for the discovery of innovative drugs in a large number of pathologies and various biologically relevant RNAs that could serve as drug targets have already been identified.1 Among the most important ones\, it is worth to mention prokaryotic ribosomal RNA which is the target of a number of currently employed antibiotics\, viral RNAs such as TAR\, RRE and DIS RNA of HIV-1 or oncogenic microRNAs that are tightly involved in the development and progression of various cancers.2 However\, difficulties in the rational design of strong and specific small-molecule ligands renders this kind of molecules relatively rare. \n\n\n\nIn this presentation\, the structure-based design of new RNA ligands targeting oncogenic RNAs will be illustrated together with the identification of new compounds bearing a promising biological activity.3 Also\, it will be shown how the active binders can be employed as chemical tools for a better understanding of the formed interactions toward the design of optimized compounds.4 Finally\, the use of RNA binders for the validation of new antibacterial targets against resistant bacterial strains will be described to highlight the potential of the small-molecule approach in RNA targeting. \n\n\n\nReferences \n\n\n\n[1] J. Childs-Disney\, X. Yang\, Q. Gibaut\, Y. Tong\, R. Batey\, M. Disney\, Nat. Rev. Drug. Discov. 2022\, 21\, 736. \n\n\n\n[2] J. Falese\, A. Donlic\, A. Hargrove\, Chem. Soc. Rev. 2021 50\, 2224. \n\n\n\n[3] D. D. Vo\, C. Becquart\, T. Tran\, A. Di Giorgio\, F. Darfeuille\, C. Staedel\, M. Duca\, Org. Biomol. Chem. 2018 16\, 6262; C. Staedel\, T. Tran\, J. Giraud\, F. Darfeuille\, A. Di Giorgio\, N. Tourasse\, F. Salin\, P. Uriac\, M. Duca\, Sci. Rep. 2018 8\, 1667. \n\n\n\n[4] Maucort\, C.\, Vo\, D.D.\, Aouad\, S.\, Charrat\, C.\, Azoulay\, S.\, Di Giorgio\, A.\, Duca\, M. ACS Med. Chem. Lett. 2021 12\, 899; Tran\, T.P.A.\, Poulet\, S.\, Pernak\, M.\, Rayar\, A.\, Azoulay\, S.\, Di Giorgio A.\, Duca\, M. RSC Med. Chem. 2022 13\, 311; Scheheoleva I.\, Fernandez-Remacha\, D.\, Estrada-Tejedor\, R.\, Duca\, M.\, Michelet\, V. Chem. Eur. J. 2023 doi.org/10.1002/chem.202300825 URL:https://www.scilifelab.se/event/the-svedberg-seminar-maria-duca/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230918T151500 DTEND;TZID=Europe/Stockholm:20230918T161500 DTSTAMP:20260511T013702 CREATED:20230831T123817Z LAST-MODIFIED:20230904T061932Z UID:10000963-1695050100-1695053700@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Female sex hormones and the human microbiome DESCRIPTION:Luisa Hugerth \n\n\n\nAssistant ProfessorDDLS FellowDepartment of Medical Biochemistry and Microbiology\, UU \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\n\n\n\n\nLuisa Hugerth has a background in molecular biology and biomedicine\, but got her PhD in 2016 at KTH Royal Institute of Technology with an analysis of microbial community time-series in the Baltic Sea. After that\, Dr. Hugerth spent 6 years at the Centre for Translational Microbiome Research in Karolinska Institutet\, where she studied the human microbiome in functional bowel disorders\, before becoming deeply involved in research on the microbiome of pregnant and non-pregnant women. Since 2022\, she is a DDLS fellow in epidemiology and biology of infection at Uppsala University’s Department of Medical Biochemistry and Microbiology\, Imbim \n\n\n\n \n\n\n\nFemale sex hormones and the human microbiome\n\n\n\nEstrogen and progesterone have pleitropic effects throughout the body. This includes mucosal surfaces and the diverse microbial communities that inhabit them. Microbiota can enhance or dampen these effects\, thereby acting as risk mediating factors for various diseases\, most notably gynecologic and periodontal inflammation. The vaginal microbiota has been epidemiologically linked to various outcomes\, from STI acquisition to preterm birth. The oral microbiota has also been causally linked to as disparate outcomes as preterm birth and newly onset depression. Here\, I will present ongoing work on the interplay between endogenous and exhogenous hormones on the oral\, vaginal and gut microbiome\, in women with a regular menstrual cycle as well as pregnant women. Additionally\, since both sex hormones and the gut microbiome are implicated in mood disorders\, I will touch upon the gut-brain axis in relation to pregnancy nausea and perinatal depression. \n\n\n\n\n\n\n\n\n\n\n\nHost: Mikael Sellin mikael.sellin@imbim.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-luisa-hugerth/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230904T151500 DTEND;TZID=Europe/Stockholm:20230904T161500 DTSTAMP:20260511T013702 CREATED:20230822T111554Z LAST-MODIFIED:20230822T112432Z UID:10000957-1693840500-1693844100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Toward Multidimensional Spectral Flow Cytometry: Entering the Quantum Cytometry Domain DESCRIPTION:J. Paul Robinson\, Professor \n\n\n\nDistinguished Professor of Cytometry \n\n\n\nProfessor of Biomedical Engineering \n\n\n\nPurdue University\, USA \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\n\n\n\n\nDr. Robinson received his early education at the University of NSW\, Sydney Australia where he received a B.Sc. (Hons)\, M.Sc. and Ph.D. degrees. He was a postdoctoral fellow in the University of Michigan Medical School then a junior faculty in the School of Pathology prior to moving to Purdue University where he was promoted to full professor in 1993. \n\n\n\nDr. Robinson is currently a Distinguished Professor of Cytometry\, and Professor of Biomedical Engineering in the Weldon School of Biomedical Engineering. He also holds appointment in the Purdue Polytechnic Institute\, School of Computer and Information Technology and IU School of Medicine. Dr. Robinson is a Fellow of the American Institute for Medical and Biological Engineering\, a Fellow of the American Association for the Advancement of Science\, a Fellow of the National Academy of Inventors and a Fellow of the Royal Microscipal Society.  Dr. Robinson is a past president of the International Society for Advancement of Cytometry and is the past Editor-in-Chief of Current Protocols in Cytometry. \n\n\n\nHe is an accomplished researcher with over 210 peer-reviewed papers\, over 400 conference presentations\, 10 books\, 15 CDs or DVDs published and over 160 invited international keynote lectures and over 20 issued patents. He formed the Purdue Cytometry Electronic Discussion list in 1989 (http://cyto.purdue.edu/hmarchiv/index.htm) and it continues today with 4500 participants. \n\n\n\nDr. Robinson is the inventor of the key patent on spectral flow cytometry that has been commercialized and morphed into one of the most significant technologies in the field of fluorescence-based single cell detection. In this regard\, together with his colleague Masanobu Yamamoto\, they recently developed the most sensitive\, highest speed single photon detector technology that is likely to have future impact on the field.  He has also worked for many years on detection technologies in the area of food borne pathogens. More recently his group has been focused on developing new approaches to toxin and pathogen detection using laser induced breakdown spectroscopy (LIBS). By combining lanthanide conjugated antibodies as target molecules for toxins\, it is possible to create a rapid detection assay that can be highly multiplexed. \n\n\n\nDr. Robinson is an accomplished mountaineer having summited several of the world’s most difficult mountains including Everest\, (8\,849m\, May 23\, 2009); Manaslu (8\,163m\, Oct 3\, 2008); and McKinley (6\,191m\, Jul 1\, 2008). In 2006 he formed the not-for-profit foundation “Cytometry for Life” (www.cytometyforlife.org) as a mechanism to promote low-cost diagnostics and education primarily in Africa and this organization continues working today to expand education and training in Africa in conjunction with AIBBC (https://www.aibbc-society.org). \n\n\n\n \n\n\n\nToward Multidimensional Spectral Flow Cytometry: Entering the Quantum Cytometry Domain\n\n\n\nFor decades flow cytometry has been a go-to technology for single cell analysis. There are clear advantages for analysis of complex suspensions of cells\, particularly when considering blood cell analysis. The principles for the latest iteration for flow cytometry technology is a spectral approach with is now 2 decades old since we first developed this approach in 2001-2003. Spectral flow cytometry has become the driving technology in the field over the past 5-7 years. What spectral cytometry has brought to the field is a vast increase in multiparameter assay capability now approaching 50 simultaneous fluorescent probes. \n\n\n\nHowever\, what we see as the future of cytometry is often based on our current view of what we presently have. And the question arises can we envisage a technology that is different from what we currently understand and use? This is a difficult question as most of us can’t exactly predict the future! What we do know is there are new tools out there that can become integrated into the field. \n\n\n\nThere is a potential for a 2nd generation spectral technology that we have been working on that may provide many more features that we currently consider when we design our experiments. This presentation will discuss the engineering developments in both current spectral analyzers and spectral cell sorters and outline the next-generation technology that will open up new frontiers in biotechnology research in both research and clinical diagnostics.  The focus will be around how do we approach quantum cytometry? Can we move from the analog world to the digital world – that is to the world where we deal with single photons – the photon being the ultimate digital event?  This requires new sensors for high-speed detection. New sensors require better optics  – more advanced diffraction approaches for light collection than currently available. High-speed sensors demand high speed electronics moving from the megahertz to the gigahertz domain. In all\, moving to quantum cytometry means redefining most of the technology that we have been using for decades.  There is a saying that “you cannot put new wine into old wine skins”! The technical demands for quantum cytometry are far more stringent that current systems allow. However\, when you meet these criteria\, the opportunities for biological detection approaches expands enormously. This presentation will outline a new sensor technology\, new laser/electronics technology and how this will generate datasets that require advanced analytical toolsets demanding AI for potentially automated diagnostics. \n\n\n\n\n\n\n\n\n\n\n\nHost: Masood Kamali-Moghaddam masood.kamali@igp.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-paul-robinson/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230613T151500 DTEND;TZID=Europe/Stockholm:20230613T161500 DTSTAMP:20260511T013702 CREATED:20230524T093330Z LAST-MODIFIED:20230524T130749Z UID:10000897-1686669300-1686672900@www.scilifelab.se SUMMARY:[The Svedberg seminar] -Physical activity and cancer: Improving causal inference DESCRIPTION:NOTE THAT THIS SEMINAR IS ON A TUESDAY \n\n\n\nBrigid M. Lynch\, Associate Professor \n\n\n\nDeputy Head\, Cancer Epidemiology Division\, Cancer Council Victoria \n\n\n\nHonorary Principal Fellow\, Centre for Epidemiology and Biostatistics\, Melbourne School of Population and Global Health\, University of Melbourne\, Australia \n\n\n\nBio\n\n\n\n \n\n\n\n\n\n\n\nBrigid Lynch is a cancer epidemiologist whose research focuses on how physical activity is associated with cancer risk\, biological mechanisms underlying risk\, and health outcomes for cancer survivors. Her research interests include applying causal inference methods to help advance the field of physical activity epidemiology. Brigid is a Principal Investigator of the Australian Breakthrough Cancer Study\, an ongoing cohort study of over 50\,000 Australians investigating the role that genes\, lifestyle and environment play in the development of cancer and other diseases. \n\n\n\n \n\n\n\nPhysical activity and cancer: Improving causal inference\n\n\n\nCancer is a leading cause of ill health and mortality; a clear understanding of cancer risk factors is critical to developing effective cancer control strategies. Physical activity has a protective effect for a number of cancers\, however it is – at best – a tangential focus of cancer control agencies around the world. The epidemiological evidence for physical activity and cancer (both in terms of risk and survivorship after diagnosis) is subject to numerous biases\, creating a lack of certainty about causal effects. This presentation will present example studies focused on breast cancer to describe how we can triangulate evidence from different methods to improve causal inference in this field of enquiry. \n\n\n\n\n\n\n\n\n\n\n\nHost: Emerald Heiland\, UU emerald.heiland@surgsci.uu.se and Hannah Brooke\, UU hannah.brooke@surgsci.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-physical-activity-and-cancer-improving-causal-inference/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230522T151500 DTEND;TZID=Europe/Stockholm:20230522T161500 DTSTAMP:20260511T013702 CREATED:20230502T162232Z LAST-MODIFIED:20230503T062420Z UID:10000874-1684768500-1684772100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Photo-“click” and photo-“unclick” strategies for spatiotemporal control of substrate immobilization and release DESCRIPTION:Vladimir Popik \, Professor of Chemistry \n\n\n\nUniversity of Georgia\, USA \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nVladimir Popik received his MSc degree (Chemistry) from the Leningrad State University (1986\, Leningrad\, USSR). His PhD project “Conformational Structure and Photochemical Reactivity of 1\,3-Diazodicarbonyl Compounds” was under the supervision of Prof. Irina Korobitcina and Valery Nikolaev at St. Petersburg State University (same school\, new name). After defending his PhD dissertation in 1990\, he continued as a Research Scientist. In 1992 joined Prof. A. Jerry Kresge group at the University of Toronto as a postdoc then accepted Visiting Research Professor position at the University of Toronto in 1996. In 1999 Valdimir joined the faculty of the Center for Photochemical Sciences at the Bowling Green State University as an Assistant Professor. In 2005 he was promoted to Associate Professor. In 2006 Vladimir Popik moved to the University of Georgia where he is now Professor of Chemistry. \n\n\n\nAwards: NSF Career Award 2004; Georgia Cancer Coalition Distinguished Scholar 2006; Senior Member of the National Academy of Inventors 2022.Research interests: devlopment of photochemical tools for biochemical\, bioimaging\, and material sciences applications; practical use of two-photon photochemistry; development of novel strategies for click and photoclick ligations; rational design and synthesis light-activated antimitotic agents and gasotransmitteres; investigation of the mechanism of fast reactions.120 Peer-reviewed publications\, (h-index = 41) \, 10 patents. \n\n\n\n \n\n\n\nPhoto-“click” and photo-“unclick” strategies for spatiotemporal control of substrate immobilization and release\n\n\n\nPhotochemical triggering of “click” reactions permits the spatial and temporal control of the derivatization\, labelling\, cross-linking and patterning of various substrates. The absence of potentially detrimental catalysts and/or activating reagents is another beneficial feature of this approach. “Photo-SPAAC” click strategy is based on the photo-decarbonylation of cyclopropenone moiety incorporated into an 8-membered ring. Induction of photo-“click” ligation using two-photon excitation with NIR light (700 – 800 nm or ~ 1100 nm) allows for the 3-dimensional control of the process.Photo-cleavable linkers\, on the other hand\, allow for the spatiotemporal control of the substrate release. \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nHost: Daniel Fürth\, UU furth@scilifelab.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-photo-click-and-photo-unclick-strategies/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230508T151500 DTEND;TZID=Europe/Stockholm:20230508T161500 DTSTAMP:20260511T013702 CREATED:20230412T095910Z LAST-MODIFIED:20230414T114147Z UID:10000854-1683558900-1683562500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Global mapping of protein subcellular location offers a new era of comparative and evolutionary cell biology. DESCRIPTION:Ross Waller \, Professor of Evolutionary Cell Biology \n\n\n\n Department of Biochemistry \n\n\n\nUniversity of Cambridge\, UK \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nRoss Waller completed a PhD in 2000 at the University of Melbourne working on the newly discovered remnant plastid in apicomplexan parasites Plasmodium and Toxoplasma. He undertook postdoctoral training from 2000-3 as a Peter Doherty Fellow working on Leishmania cell biology (University of Melbourne)\, and then from 2003-5 as a Canadian Institutes of Health Research working on molecular evolution in diverse eukaryotes at the University of British Columbia. In 2005 be joined the faculty of the School of Botany\, University of Melbourne\, and in 2013 relocated his laboratory to the Department of Biochemistry\, University of Cambridge. \n\n\n\n \n\n\n\nGlobal mapping of protein subcellular location offers a new era of comparative and evolutionary cell biology\n\n\n\nMost of the diversity of eukaryotic life is represented by unicellular organisms\, and most of this has diverged from well-studied model organisms by over a billion years of evolution. Consequently\, while core eukaryotic cellular and molecular biology is often conserved\, this represents only a small fraction of the molecular diversity\, organisation\, and function of most cells. This\, in turn\, severely constrains our ability to infer the biology of most of eukaryotic life from the better-studied models such as animals and fungi. To address the need for de novo characterisation of cells’ molecular diversity we use a spatial proteomics method called LOPIT that simultaneously captures the steady-state subcellular locations of thousands of proteins. We use these new cellular blueprints as springboards to study the evolutionary processes\, adaptations and trajectories that have contributed to eukaryotic cell diversity\, with particular focus on understanding the apicomplexan parasites and their close algal relatives the dinoflagellates. \n\n\n\n \n\n\n\nHost: Fabien Burki\, UU fabien.burki@ebc.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-global-mapping-of-protein-subcellular-location/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230424T151500 DTEND;TZID=Europe/Stockholm:20230424T161500 DTSTAMP:20260511T013702 CREATED:20230331T130042Z LAST-MODIFIED:20230331T130044Z UID:10000848-1682349300-1682352900@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Copy-Number Changes During Experimental Evolution in Caenorhabditis elegans: Rate\, Fitness Effects and Context-Dependence DESCRIPTION:VAISHALI KATJU \, Professor \n\n\n\nProgram in Evolutionary Biology \n\n\n\nDepartment of Ecology & Genetics \n\n\n\nUppsala University \n\n\n\n\n\n\n\n\n\n\n\nBio\n\n\n\nProf. Katju is an evolutionary geneticist whose research combines the power of experimental evolution with the model nematode C. elegans and high-throughput genomics to address fundamental questions in biology and evolution regards the rates\, fitness effects and evolutionary dynamics of spontaneous mutations. Her current and future research program is focused on investigating (i) the consequences of spontaneous mutation under varying intensity of selection\, (ii)mitochondrial evolution and the genetic architecture of mitonuclear interactions and (iii) the transcriptional and functional consequences of copy-number changes during adaptation. \n\n\n\nD. Katju earned her Ph.D. in Evolutionary Genetics from Indiana University-Bloomington\, USA in 2004 under the supervision of Dr. Michael Lynch. Following the completion of a National Science Foundation funded Postdoctoral Research Fellowship in Biological Informatics\, she served as a faculty member (Assistant and Associate Professor) in the Department of Biology at the University of New Mexico from 2007-2015. From 2015-2022\, she was a faculty member (Associate and full Professor) in the Department of Veterinary Integrative Biosciences in the College of Veterinary Medicine at Texas A&M University. In 2022\, she joined the Department of Ecology and Genetics at Uppsala University as a Professor. \n\n\n\n \n\n\n\nCopy-Number Changes During Experimental Evolution in Caenorhabditis elegans: Rate\, Fitness Effects and Context-Dependence\n\n\n\n \n\n\n\nThe genomic era has revealed that gene copy-number differences due to gene duplications and deletions are rampant in natural populations. Yet\, base substitutions as a mutational class have dominated the field of evolutionary biology as the main contributor to genetic variation leading to evolution. Herein\, I briefly explore the history of the field\, from the neo-Darwinian synthesis through Ohno’s canonical model for the evolution of gene duplicates and its failure to encapsulate the full complexity of the duplication process. Lastly\, I present results from three long-term experimental evolution experiments in Caenorhabditis elegans that investigate fundamental properties of copy-number variants (CNVs)\, including (i) direct estimates of their rates of origin\, (ii) evidence that CNVs constitute a common mechanism of adaptive genetic change during compensatory evolution\, and (iii) evidence that duplications and deletions of highly transcribed genes are detrimental to fitness and a role for selection against an increase in transcript abundance. \n\n\n\nHost: Leif Andersson leif.andersson@imbim.uu.se UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-copy-number-changes-during-experimental-evolution-in-caenorhabditis-elegans-rate-fitness-effects-and-context-dependence/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230327T151500 DTEND;TZID=Europe/Stockholm:20230327T161500 DTSTAMP:20260511T013702 CREATED:20230302T102710Z LAST-MODIFIED:20230316T132039Z UID:10000823-1679930100-1679933700@www.scilifelab.se SUMMARY:[The Svedberg seminar] - The Underlying Cause of Human Autoimmune Disease DESCRIPTION:DAVID A. HAFLER\, MD\, FANA \n\n\n\nWilliam S. and Lois Styles Professor of Neurology and ImmunobiologyChair\, Department of Neurology\, Yale School of MedicineNeurologist-in-Chief\, Yale New Haven HospitalFounding Associate Member\, Broad Institute of MIT and Harvard \n\n\n\nBio\n\n\n\nDavid A. Hafler\, M.D. is the William S. and Lois Stiles Edgerly Professor and Chairman Department ofNeurology and Professor of Immunobiology\, Yale School of Medicine\, and is the Neurologist-in-Chiefof the Yale-New Haven Hospital. He has made seminal discoveries in the pathogenesis of multiplesclerosis and autoimmune diseases including identification of human autoreactive T cells andthe mechanisms that underlie their dysregulation with the discovery of human regulatory T cells.He led the discovery of genetic variants causing. He was awarded the Dystel Prize for MS researchand the 2023 AAI Steinman Award for Human Immunology Research. He is an Honorary Member ofthe Scandinavian Society for Immunology and has been elected to membership in the AmericanSociety of Clinical Investigation\, The Association of American Physicians\, and the National Academy of Medicine. \n\n\n\nThe Underlying Cause of Human Autoimmune Disease\n\n\n\n \n\n\n\nMultiple sclerosis (MS) is a prototypic\, genetically mediated autoimmune disease induced by environmental factors where genetic perturbation of cis-regulatory elements leads to immune dysregulation and generation of myelin reactive T cells secreting inflammatory cytokines. We have identified 233 common allelic variants associated with MS risk where approximately 60% of candidate causal variants map to enhancers and super-enhancers marked by chromatin features in T and B cells. We found that CD4+Foxp3+ Tregs are defective in MS and by performing transcriptomic and epigenomic profiling discovered that upregulation of a primate-specific short PRDM1 isoform (PRDM1-S) induces SGK1 independent from evolutionally conserved long PRDM1\, leading to destabilization of Foxp3 and Treg dysfunction. This aberrant PRDM1-S/SGK1 axis is shared among other autoimmune diseases and it is of interest that SGK-1 is induced by high salt\, an environmental risk factor in MS. Finally\, as suggested by genetic mapping\, B cells play a critical role in the disease and B cell depletion is highly effective in treating early disease. \n\n\n\nHost: Katarina Lundblad katarina.lundblad@neuro.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-the-underlying-cause-of-human-autoimmune-disease/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230320T151500 DTEND;TZID=Europe/Stockholm:20230320T161500 DTSTAMP:20260511T013702 CREATED:20230227T125936Z LAST-MODIFIED:20230307T082548Z UID:10000822-1679325300-1679328900@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Protein engineering for functional hybrids and biomaterials: applications in biomedicine and technology DESCRIPTION:Prof. Aitziber Cortajarena \n\n\n\nResearch Professor Scientific DirectorCenter for Cooperative Research in Biomaterials (CIC biomaGUNE) Spain \n\n\n\n\n\n\n\nBio\n\n\n\nProf. Aitziber Cortajarena earned her Ph.D. in Biochemistry from the Universidad del País Vasco in 2002. Then\, she worked on protein design in the group of Dr. Lynne Regan at Yale University\, USA\, as a Postdoctoral Fellow and Associate Research Scientist. She joined IMDEA Nanociencia in 2010 and started her independent research in nanobiotechnology. In 2016\, she joined CIC biomaGUNE as Ikerbasque Research Professor. Currently\, she leads the Biomolecular Nanotechnology group and is Scientific Director at CIC biomaGUNE. \n\n\n\nHer research focuses on protein engineering toward the generation of functional nanostructures and bioinspired materials for applications in nanobiotechnology and nanomedicine. \n\n\n\nProtein engineering for functional hybrids and biomaterials: applications in biomedicine and technology\n\n\n\nProteins are the most versatile biological building blocks\, composed of smaller units called amino acids\, which offer a rich chemisty. The diverse 3D structures of proteins translate into a wide range of functionalities\, making them ideal candidates for use as building blocks in tailored nanofabrication and the creation of novel protein-based functional composites and biomaterials. \n\n\n\nIn our group\, we aim to leverage the potential of engineered proteins as building blocks for the generation of functional nanostructures and bioinspired materials for a wide range of applications in technology and biomedicine. Our goal is to create versatile platforms based on simple protein building blocks\, which can be used to fabricate a variety of protein-based functional composites and biomaterials. \n\n\n\nTo demonstrate the potential of these engineered protein-based systems\, several examples will be shown\, including their use in catalysis\, bioelectronics\, biosensing\, and for the treatment and diagnosis of diseases. \n\n\n\nHost: Antonietta Parracino antonietta.parracino@kemi.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-protein-engineering-for-functional-hybrids-and-biomaterials-applications-in-biomedicine-and-technology/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230118T151500 DTEND;TZID=Europe/Stockholm:20230118T161500 DTSTAMP:20260511T013702 CREATED:20230108T194843Z LAST-MODIFIED:20230110T091905Z UID:10000781-1674054900-1674058500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - High-throughput biology at the organismal level DESCRIPTION:Jan 18\, at 15:15 in BMC\, C8:301 \n\n\n\nProf. Randall Peterson\,Dean\, College of PharmacyDepartment of Pharmacology and Toxicology\, University of Utah\, USA \n\n\n\nBio\n\n\n\nRandall T. Peterson\, PhD is a chemical biologist whose research utilizes high-throughput screening technologies to discover new drug candidates for cardiovascular and nervous system disorders. Unlike conventional drug discovery programs that utilize simplified\, in vitro assays\, the Peterson lab screens using living zebrafish\, ensuring that the drug candidates discovered are active in vivo. Several of the compounds discovered by the Peterson laboratory have become widely used research tools or preclinical drug candidates.Dr. Peterson received his PhD from Harvard University where he studied as a Howard Hughes Medical Institute predoctoral fellow in the laboratory of Stuart Schreiber.  He completed a postdoctoral fellowship with Mark Fishman at Massachusetts General Hospital. Dr. Peterson spent 14 years as a faculty member at Harvard University where he was the Charles Addison and Elizabeth Ann Sanders Chair in Basic Science at Harvard Medical School\, Scientific Director of the MGH Cardiovascular Research Center\, and Senior Associate Member of the Broad Institute.  In 2017 he moved to the University of Utah as L.S. Skaggs Presidential Endowed Professor and Dean of the College of Pharmacy. \n\n\n\nTitle of the talk: High-throughput biology at the organismal level\n\n\n\nThe impact of high-throughput technologies on biological research has been remarkable. For example\, high-throughput drug screens have revolutionized drug discovery\, and high-throughput CRISPR screens are revolutionizing gene discovery. Notably\, these techniques have focused almost entirely on simple\, in vitro or cell-based assays\, leaving untouched organismal processes such as embryonic development\, physiology\, and animal behavior. These organismal processes are best studied in vivo\, and consequently have not been amenable to high-throughput biology. The Peterson lab is focused on applying high-throughput technologies to such organismal processes and is developing methodologies that enable CRISPR screens and small molecule screens to be applied to organismal processes in zebrafish. Recently\, we have discovered small molecules and genes with novel activities on the cardiovascular\, nervous\, and endocrine systems. I will describe how the compounds and genes were discovered\, what they have taught us about biology\, and how they might find practical or clinical utility. \n\n\n\nHost: Marcel den Hoed marcel.den_hoed@igp.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-randall-peterson-prof/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT END:VCALENDAR