BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//SciLifeLab - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.scilifelab.se
X-WR-CALDESC:Events for SciLifeLab
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Stockholm
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20200329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20201025T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240226T151500
DTEND;TZID=Europe/Stockholm:20240226T161500
DTSTAMP:20260511T023612
CREATED:20240207T162516Z
LAST-MODIFIED:20240207T162519Z
UID:10001149-1708960500-1708964100@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Spatial biodiversity modeling with remote sensing and AI
DESCRIPTION:Tobias Andermann \n\n\n\nAssistant Professor\, DDLS fellowUppsala University  \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nTobias Andermann is a biodiversity researcher dedicated to providing data and computatio- nal tools for combating the global biodiversity crisis. His group\, the Biodiversity Data Lab\, is working on the intersection of molecular biology\, spatial ecology\, and machine learning\, with the mission to provide a more comprehensive view on the distribution of biodiversity\, including hidden diversity of inconspicuous and even undescribed species through the use of environmental DNA. \n\n\n\n \n\n\n\nSpatial biodiversity modeling with remote sensing and AI\n\n\n\nThere is an ever-increasing need for developing standardized ways of quantifying the biodiversity value of a site. This need arises from international and local policies (e.g. the COP15 UN Biodiversity agreement) as well as from the independent investments of companies world-wide in developing biodiversity-positive profiles\, motivated by their public perception. This momentum provides an unprecedented opportunity to efficiently protect biodiversity on a large scale to turn around the alarmingly negative biodiversity trends of the recent decades and centuries. While individual biodiversity assessments for specific sites can be done through targeted inventories\, either through taxonomic experts or increasingly through the use of environmental DNA\, we also need ways of scaling up such biodiversity evaluations to larger scales\, covering entire regions or countries. AI models provide a unique tool to leverage complex biodiversity and remote sensing data to make predictions of biodiversity on large spatial scales\, while at the same time providing high spatial resolution. In this talk I will present some of these models from my ongoing research and discuss their utility\, as well as their current shortcomings and limitations. \n\n\n\n \n\n\n\n\n\n\n\nHost: Joëlle Rüegg joelle.ruegg@ebc.uu.se\, UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-tobias-andermann/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240129T151500
DTEND;TZID=Europe/Stockholm:20240129T161500
DTSTAMP:20260511T023612
CREATED:20240109T110554Z
LAST-MODIFIED:20240109T135707Z
UID:10001101-1706541300-1706544900@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - The Impossibility of Whales: somatic evolution across the tree of life
DESCRIPTION:Alex Cagan \n\n\n\nAssistant ProfessorUniversity of Cambridge\, UK \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nAlex Cagan is an Assistant Professor at the Departments of Genetics\, Pathology and Veterinary Medicine at the University of Cambridge and affiliate of the Programme for Cancer\, Ageing and Somatic Mutation at the Wellcome Sanger Institute. He obtained his PhD in comparative genomics with Svante Pääbo at the Max Planck Institute for Evolutionary Anthropology before doing a post-doc with Inigo Martincorena at the Wellcome Sanger Institute to develop methods to study somatic evolution. His work focuses on the development and application of methods to study somatic evolutionary processes across species to gain insights into cancer\, ageing and environmental monitoring. Alex is also enthusiastic about science illustration and communication. \n\n\n\n \n\n\n\nThe Impossibility of Whales: somatic evolution across the tree of life\n\n\n\nSomatic mutations accumulate in cells throughout life. They underpin the development of cancer and may contribute to ageing. Studying these mutations in healthy tissues has been challenging due to the difficulty of detecting mutations present in single cells or small clones in a tissue. Recent technical advances are enabling their study\, revealing how cells accumulate mutations at different rates and how clonal expansions of mutant cells colonise tissues. Yet little is known about how these processes operate in non-human species. We performed whole-genome sequencing of 208 intestinal crypts from 56 individuals to study the landscape of somatic mutation across 16 mammalian species. This comparative analysis of somatic mutagenesis shed light on the diversity of mutagenic processes across species\, and on long-standing questions regarding the evolution of somatic mutation rates and their role in cancer and ageing. We are now developing methods to enable the study of somatic evolution across any cell type in any species. These approaches aim to provide insights into the evolutionary origin of somatic mutational processes and the mechanisms that underlie cancer resistance in species where cancer is rare.   \n\n\n\n \n\n\n\n\n\n\n\nHost: Matthew Webster matthew.webster@imbim.uu.se\, UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-alex-cagan/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20240122T151500
DTEND;TZID=Europe/Stockholm:20240122T161500
DTSTAMP:20260511T023612
CREATED:20231211T083458Z
LAST-MODIFIED:20240110T165531Z
UID:10001067-1705936500-1705940100@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Nucleosomes for all: histone-based chromatin in noneukaryotic organisms
DESCRIPTION:Karolin Luger \n\n\n\nProfessor University of Colorado\, USA \n\n\n\nPLEASE NOTE: This seminar will be given both in Uppsala\, BMC at January 22:nd and additionally in Solna at January 23\, 14:00\, George and Eva Klein\, Biomedicum\, Solnavägen 9\, Stockholm \n\n\n\n\n\n\n\nBio\n\n\n\nKarolin Luger is a distinguished professor and the Jennie Smoly Caruthers Endowed Chair of Biochemistry at the University of Colorado in Boulder\, and an investigator for the Howard Hughes Medical Institute. She is recognized for her work on nucleosome structure and interacting proteins. The lab also studies the DNA damage recognition protein PARP1 and its interactions with chromatin\, with the aim of developing novel PARP inhibitors for cancer therapy. The group explores histone-based DNA organization in non-eukaryotic organisms\, to gain insight into the evolutionary origin of the nucleosome. \n\n\n\nLuger was born in Austria and obtained a degree in Biochemistry from the University of Innsbruck. She obtained her Ph.D. in biophysics from the Biocenter Basel\, then moved to a postdoc at the ETH Zuerich in 1990. She started her independent career at Colorado State University in 1999\, and in 2015 moved to the University of Colorado at Boulder. She is a fellow of the Biophysical Society\, a member of the National Academy of Science; the American Academy of Arts and Science; and EMBO. In 2023\, she was awarded the World Laureate Association (WLA) Prize in Life Science or Medicine for her groundbreaking work on nucleosome structure. \n\n\n\n \n\n\n\nNucleosomes for all: histone-based chromatin in noneukaryotic organisms\n\n\n\nAll eukaryotes organize their DNA into nucleosomes\, consisting of an octamer of the four core histone proteins H2A\, H2B\, H3\, and H4\, around which 147 base pairs of DNA are wrapped in two tight superhelical turns. Histones were an early acquisition in eukaryogenesis that allowed for massive genome expansion\, a prerequisite for the complexity observed in modern-day eukaryotes. Histones are the targets of epigenetic modifications through the incorporation of histone variants and histone post-translational modifications\, and require elaborate assembly and remodeling machinery for gene regulation. Who provided the chromatin starter kit to the early eukaryote? Many archaea organize their genomes with single\, non-diversified histones that form slinky-like structures\, without the requirement for additional machinery to assemble and disassemble nucleosomal structures.  A subclass of giant viruses (ancient double-stranded DNA viruses that infect amoebae) also encode their own histones\, and these form meta-stable nucleosome-like structures with distinct features. Unexpectedly\, we recently discovered that histones are sporadically present in the bacterial domain of life. In a stunning reversal of ‘histone logic’\, these small histones encase straight DNA rather than wrapping it around them.  As such\, histones are no longer a prerogative of eukaryotes but appear to be an ancient DNA packaging principle that has adapted to varying constraints in different domains of life. \n\n\n\n \n\n\n\n\n\n\n\nHost: Sebastian Deindl sebastian.deindl@icm.uu.se UU\, Simon Elsässer simon.elsasser@scilifelab.se\, KI
URL:https://www.scilifelab.se/event/the-svedberg-seminar-karolin-luger/
LOCATION:BMC Trippelrummet\, Husargatan 3\, entrance C11\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231218T151500
DTEND;TZID=Europe/Stockholm:20231218T161500
DTSTAMP:20260511T023612
CREATED:20231123T133956Z
LAST-MODIFIED:20231123T134046Z
UID:10001039-1702912500-1702916100@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Describing tissue pathogenesis with spatial technologies
DESCRIPTION:Sanja Vickovic \n\n\n\nWallenberg Academy Fellow and SciLifeLab FellowDepartment of Immunology\, Genetics and Pathology at Uppsala University \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nDr. Vickovic is currently a Wallenberg Academy Fellow and SciLifeLab Fellow at the Department of Immunology\, Genetics and Pathology at Uppsala University. Dr. Vickovic received her PhD in Gene Technology from the Royal Institute of Technology in Stockholm. Following her graduate work\, Dr. Vickovic joined the Broad Institute of MIT and Harvard\, Columbia University and the New York Genome Center before continuing in her current role as Assistant Professor at Uppsala University. Dr. Vickovic has extensively worked on pioneering novel spatially resolved transcriptomics and genomics methods that enable massively parallel in situ profiling of intact tissue samples.  \n\n\n\nDescribing tissue pathogenesis with spatial technologies\n\n\n\nAbstract: Spatial and molecular characteristics determine tissue function\, yet high-resolution methods to capture both concurrently are lacking. In recent years\, we developed high-definition spatial transcriptomics and multi-omics technologies\, which captures RNA\, protein information or microbiota from histological tissue sections on spatially barcoded arrays. Today\, I will present how these different technologies were developed and are applied in different biological settings. \n\n\n\n \n\n\n\n\n\n\n\nHost: Ulf Landegren ulf.landegren@igp.uu.se\, UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-sanja-vickovic/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231208T151500
DTEND;TZID=Europe/Stockholm:20231208T161500
DTSTAMP:20260511T023612
CREATED:20231124T084624Z
LAST-MODIFIED:20231124T084626Z
UID:10001040-1702048500-1702052100@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Engineered Salmonella for drug delivery to solid tumors
DESCRIPTION:Neil Forbes \n\n\n\nProfessor of Chemical EngineeringUniversity of Massachusetts\, USA \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nNeil Forbes is a Professor of Chemical Engineering at the University of Massachusetts\, Amherst. He is an adjunct member of the Molecular and Cell Biology Program and a member of the Institute for Applied Life Sciences. He received a BS in Chemical Engineering from Case Western Reserve University\, received a PhD in Chemical Engineering from the University of California at Berkeley (with Harvey Blanch and Douglas Clark)\, and was a postdoctoral fellow (with Rakesh Jain) in Radiation Oncology at Harvard Medical School / Massachusetts General Hospital. \n\n\n\nEngineered Salmonella for drug delivery to solid tumors\n\n\n\nAbstract: Engineered bacteria have the potential to overcome the limitations that cause cancer therapies to fail. We have created intracellular delivering Salmonella that accumulate in tumors over healthy tissue and deposit deliver therapeutic payloads directly into the cytoplasm of cancer cells. Bacterial delivery of constitutively active caspase-3 blocks the growth of hepatocellular carcinoma and lung metastases\, and increases survival in mice. Salmonella delivery of an exogenous antigen\, such as from a childhood vaccine\, marks cancer cells as foreign\, and triggers a cytotoxic\, antigen-specific CD8 T cell responses. In mice\, intracellular antigen delivery clears established pancreatic tumors\, increases survival\, and prevents tumor re-implantation by establishing new immunity to intrinsic tumor antigens. This tunable platform could deliver an array of protein drugs to target many hard-to-treat intracellular pathways. As an off-the-shelf therapy\, these bacteria are not dependent on intrinsic tumor characteristics and would be effective for a broad range of cancer patients. \n\n\n\n \n\n\n\n\n\n\n\nHost: Mia Phillipson mia.phillipson@mcb.uu.se\, UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-neil-forbes/
LOCATION:BMC Room C4:301\, Husargatan 3\, entrance C1\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231204T151500
DTEND;TZID=Europe/Stockholm:20231204T161500
DTSTAMP:20260511T023612
CREATED:20231123T132908Z
LAST-MODIFIED:20231124T082227Z
UID:10001037-1701702900-1701706500@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Intersecting population genetics\, stem cell biology\, and cellular genomics to study complex human disease
DESCRIPTION:Joseph Powell \n\n\n\nProfessor Garvan Institute of Medical Research\, Sydney Australia \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nProfessor Powell is the Director of Translational Genomics at the Garvan Institute and Director of the UNSW Cellular Genomics Futures Institute. He received his PhD from the University of Edinburgh. Subsequently\, he undertook postdoctoral training with Professor Peter Visscher’s FAA FRS and started his lab in 2016. In 2018\, he was recruited as the inaugural Director of the Garvan-Weizmann Centre for Cellular Genomics and developed a multidisciplinary program in translational genomics research. \n\n\n\n\n\n\n\nAbstract: Genetic variants can contribute to disease in many ways. In complex diseases\, hundreds to thousands of variants independently contribute to disease risk\, and an accumulation of risk alleles – often combined with specific environmental exposures –is required to develop the disease phenotype. The overwhelming evidence showing enrichment of disease-associated variants in regulatory regions suggests that regulation of gene expression is likely a dominant mediator for disease risk. Expression quantitative trait loci (eQTL) analysis links disease risk-SNPs to downstream expression effects. An essential next step is defining the cellular contexts in which disease risk-SNPs affect gene expression levels. This will help better understand the molecular and cellular mechanisms by which disease risk is conferred and inform therapeutic strategies. This talk will cover a body of work on how single-cell sequencing technology can be scaled to enable the type of population genetics studies required to address these biological questions. I will present recent research on how we have resolved how genetic variation acts at the level of individual cells in immune cell and stem cell systems and outline the next steps in translating these findings into clinical impact. \n\n\n\n \n\n\n\n\n\n\n\nHost: Weronica Ek\, UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-joseph-powell/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231127T151500
DTEND;TZID=Europe/Stockholm:20231127T161500
DTSTAMP:20260511T023612
CREATED:20231113T153444Z
LAST-MODIFIED:20231113T153447Z
UID:10001029-1701098100-1701101700@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Brain-wide hierarchical and multiplexed encoding of behaviour in C. elegans
DESCRIPTION:Manuel Zimmer \n\n\n\nProfessor Department of Neuroscience and Developmental Biology\, The University of Vienna \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\n\n\n\n\nManuel Zimmer studied biochemistry at the Free University of Berlin and performed his undergraduate thesis in 1998 on neuromuscular synapse formation with Steve Burden at the Skirball Institute of Biomolecular Medicine\, New York University Medical School\, New York. Afterward\, he moved back to Germany to perform his Ph.D. work with Rüdiger Klein at the European Molecular Biology Laboratory in Heidelberg and the Max Planck Institute of Neurobiology in Munich\, until 2003. Here\, he focused on the molecular mechanisms that wire up the nervous system during development. From 2004 to 2010\, he performed his postdoctoral studies with Cori Bargmann at the University of California\, San Francisco\, and Rockefeller University\, New York. Here\, he developed lab-on-a-chip and calcium-imaging techniques to investigate the chemosensory mechanisms by which animals sense oxygen in the environment. Since 2010\, he has lived in Austria\, where he works as an independent group leader at the Research Institute of Molecular Pathology in Vienna. Dr. Zimmer’s current research is focused on how neuronal network dynamics in the brain of C. elegans arise from sleep to wakefulness to engage in processing the sensory world and to produce competent behaviors\, like foraging and navigation. \n\n\n\n \n\n\n\nBrain-wide hierarchical and multiplexed encoding of behaviour in C. elegans\n\n\n\nLarge-scale neuronal recordings in the brains of different species have revealed brain-wide\, highly coordinated patterns of neuronal activity associated with the animals’ ongoing behaviours. It is not known why behaviour is represented in the brain on such a global scale. In the nematode C. elegans\, the activity of such neuronal populations recorded from immobilised animals was suggested to correlate with brain-wide motor commands orchestrating a major action sequence. Direct confirmation of this conclusion in freely crawling animals has been lacking. I will present unpublished data from a new imaging pipeline to record brain-wide activity at single cell resolution in freely crawling animals performing a variety of motor behaviours.Extending our previous findings\, we observe population-wide neural activity in the form of a structured low-dimensional manifold from which the major motor programmes\, arranged as an action sequence\, can be decoded. However\, the brain-wide activity appears to be much richer than just encoding the identity of the main actions: while all behaviourally relevant neuronal activity patterns we detect in our recordings are modulated by the global population modes\, many individual neurons show multiplexed activity\, i.e. they carry additional residual signals. These can represent a variety of behaviourally relevant information\, such as graded movement metrics\, the animal’s undulatory gate\, or even re-afferent sensation of movement-triggered external signals.In summary\, we discover a brain-wide hierarchical organisation of behaviour in which information about the current slow time-scale behavioural state is broadcast across the brain via a low-dimensional population mode\, providing a context for the encoding of fine-tuned fast movement patterns and even sensory perception. We propose this as an organising principle that may apply to animals with larger brains. \n\n\n\nhttps://neurodevbio.univie.ac.at/zimmer-research/ \n\n\n\n\n\n\n\nHost: Klas Kullander\, UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-manuel-zimmer/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20231023T151500
DTEND;TZID=Europe/Stockholm:20231023T161500
DTSTAMP:20260511T023612
CREATED:20231006T134540Z
LAST-MODIFIED:20231006T140206Z
UID:10000993-1698074100-1698077700@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Peptide nucleic acid (PNA)-mediated pretargeting for radionuclide therapy
DESCRIPTION:Amelie Karlström \n\n\n\nProfessor of Molecular BiotechnologyDepartment of Protein Science\, KTH \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\nAmelie Eriksson Karlström is Professor of Molecular Biotechnology at the Department of Protein Science\, KTH\, where her research group is focused on protein engineering\, affinity technologies and bioconjugation chemistry for diagnostic and therapeutic applications. Amelie Eriksson Karlström has a background in solid phase peptide synthesis methodology from PhD studies at the Department of Neurochemistry and Neurotoxicology at Stockholm University. She did postdoctoral studies at the Scripps Research Institute\, La Jolla\, CA\, working on catalytic antibodies and display technologies with Profs. Richard A. Lerner and Carlos Barbas\, III\, before starting her independent research at KTH \n\n\n\n \n\n\n\nPeptide nucleic acid (PNA)-mediated pretargeting for radionuclide therapy\n\n\n\nTargeted radionuclide therapy utilizes tumor-specific radiolabeled molecules to deliver cytotoxic radiation to tumor cells. To avoid unwanted exposure of non-tumor organs\, a pretargeting strategy can be used\, where the tumor-targeting step is uncoupled from the delivery of the toxic radionuclide. The primary agent is administered first and the secondary\, radiolabeled agent is administered after the primary agent has accumulated in the tumor and cleared from non-tumor tissue. We have developed and evaluated a system for pretargeting based on the high selectivity and high affinity of peptide nucleic acid (PNA) hybridization. We have demonstrated that the PNA-based pretargeting system gives high tumor-to-normal tissue contrast in vivo both using affibody molecules and monoclonal antibodies as the tumor-targeting agents.  \n\n\n\nIn this seminar\, the molecular design and technological aspects of the PNA-based pretargeting system will be discussed. Results from preclinical evaluation of the PNA-based pretargeting strategy will be presented.  \n\n\n\n \n\n\n\n\n\n\n\n\n\n\n\nHost: Abhimanyu Thakur\,UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-amelie-karlstrom/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230925T151500
DTEND;TZID=Europe/Stockholm:20230925T161500
DTSTAMP:20260511T023612
CREATED:20230831T123645Z
LAST-MODIFIED:20230901T121318Z
UID:10000958-1695654900-1695658500@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Targeting Non-Coding RNAs Using Synthetic Small Molecules: Original Targets for Innovative Therapies
DESCRIPTION:Dr Maria Duca \n\n\n\nCNRS Research Director\, Université Côte d’Azur\, FranceWebsite: icn.univ-cotedazur.fr/tna \n\n\n\nHost: Duc Duy Vo duc.duy.vo@kemi.uu.se\, UU \n\n\n\nBio\n\n\n\nDr. Maria Duca is head of Targeting of Nucleic Acids research group in the Institute of Chemistry of Nice (Université Côte d’Azur – CNRS). After undergraduate studies in Pharmacy and Medicinal Chemistry (Faculty of Pharmacy\, University of Bologna\, Italy)\, she obtained her PhD in Molecular Biochemistry under the supervision of Dr. Paola B. Arimondo (National Natural History Museum\, Paris\, France) working on topoisomerase II inhibitors. A 2-year post-doctoral training in Sydney Hecht’s lab (Department of Chemistry\, University of Virginia\, USA) allowed her to pursue the study of nucleic acids working on targeted protein mutagenesis. After CNRS recruitment as a Research Scientist in 2008 and promotion to Director of Research in 2022\, her research activities focus on the targeting of non-coding RNAs using synthetic small molecules toward innovative therapeutic approaches for anticancer\, antiviral and antimicrobial applications. She has been awarded the Michel Delalande award from the Académie de Pharmacie as well as national and international grants including H2020 grants. She is Associate Editor for RSC Medicinal Chemistry journal\, chair of the Chemical Biology Initiative of EFMC as well as vice-president of the French medicinal chemistry society. \n\n\n\n \n\n\n\nTargeting Non-Coding RNAs Using Synthetic Small Molecules: Original Targets for Innovative Therapies\n\n\n\nRNA is one of the most intriguing and promising biological targets for the discovery of innovative drugs in a large number of pathologies and various biologically relevant RNAs that could serve as drug targets have already been identified.1 Among the most important ones\, it is worth to mention prokaryotic ribosomal RNA which is the target of a number of currently employed antibiotics\, viral RNAs such as TAR\, RRE and DIS RNA of HIV-1 or oncogenic microRNAs that are tightly involved in the development and progression of various cancers.2 However\, difficulties in the rational design of strong and specific small-molecule ligands renders this kind of molecules relatively rare. \n\n\n\nIn this presentation\, the structure-based design of new RNA ligands targeting oncogenic RNAs will be illustrated together with the identification of new compounds bearing a promising biological activity.3 Also\, it will be shown how the active binders can be employed as chemical tools for a better understanding of the formed interactions toward the design of optimized compounds.4 Finally\, the use of RNA binders for the validation of new antibacterial targets against resistant bacterial strains will be described to highlight the potential of the small-molecule approach in RNA targeting. \n\n\n\nReferences \n\n\n\n[1] J. Childs-Disney\, X. Yang\, Q. Gibaut\, Y. Tong\, R. Batey\, M. Disney\, Nat. Rev. Drug. Discov. 2022\, 21\, 736. \n\n\n\n[2] J. Falese\, A. Donlic\, A. Hargrove\, Chem. Soc. Rev. 2021 50\, 2224. \n\n\n\n[3] D. D. Vo\, C. Becquart\, T. Tran\, A. Di Giorgio\, F. Darfeuille\, C. Staedel\, M. Duca\, Org. Biomol. Chem. 2018 16\, 6262; C. Staedel\, T. Tran\, J. Giraud\, F. Darfeuille\, A. Di Giorgio\, N. Tourasse\, F. Salin\, P. Uriac\, M. Duca\, Sci. Rep. 2018 8\, 1667. \n\n\n\n[4] Maucort\, C.\, Vo\, D.D.\, Aouad\, S.\, Charrat\, C.\, Azoulay\, S.\, Di Giorgio\, A.\, Duca\, M. ACS Med. Chem. Lett. 2021 12\, 899; Tran\, T.P.A.\, Poulet\, S.\, Pernak\, M.\, Rayar\, A.\, Azoulay\, S.\, Di Giorgio A.\, Duca\, M. RSC Med. Chem. 2022 13\, 311; Scheheoleva I.\, Fernandez-Remacha\, D.\, Estrada-Tejedor\, R.\, Duca\, M.\, Michelet\, V. Chem. Eur. J. 2023 doi.org/10.1002/chem.202300825
URL:https://www.scilifelab.se/event/the-svedberg-seminar-maria-duca/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230918T151500
DTEND;TZID=Europe/Stockholm:20230918T161500
DTSTAMP:20260511T023612
CREATED:20230831T123817Z
LAST-MODIFIED:20230904T061932Z
UID:10000963-1695050100-1695053700@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Female sex hormones and the human microbiome
DESCRIPTION:Luisa Hugerth \n\n\n\nAssistant ProfessorDDLS FellowDepartment of Medical Biochemistry and Microbiology\, UU \n\n\n\n \n\n\n\n\n\n\n\nBio\n\n\n\n\n\n\n\nLuisa Hugerth has a background in molecular biology and biomedicine\, but got her PhD in 2016 at KTH Royal Institute of Technology with an analysis of microbial community time-series in the Baltic Sea. After that\, Dr. Hugerth spent 6 years at the Centre for Translational Microbiome Research in Karolinska Institutet\, where she studied the human microbiome in functional bowel disorders\, before becoming deeply involved in research on the microbiome of pregnant and non-pregnant women. Since 2022\, she is a DDLS fellow in epidemiology and biology of infection at Uppsala University’s Department of Medical Biochemistry and Microbiology\, Imbim \n\n\n\n \n\n\n\nFemale sex hormones and the human microbiome\n\n\n\nEstrogen and progesterone have pleitropic effects throughout the body. This includes mucosal surfaces and the diverse microbial communities that inhabit them. Microbiota can enhance or dampen these effects\, thereby acting as risk mediating factors for various diseases\, most notably gynecologic and periodontal inflammation. The vaginal microbiota has been epidemiologically linked to various outcomes\, from STI acquisition to preterm birth. The oral microbiota has also been causally linked to as disparate outcomes as preterm birth and newly onset depression. Here\, I will present ongoing work on the interplay between endogenous and exhogenous hormones on the oral\, vaginal and gut microbiome\, in women with a regular menstrual cycle as well as pregnant women. Additionally\, since both sex hormones and the gut microbiome are implicated in mood disorders\, I will touch upon the gut-brain axis in relation to pregnancy nausea and perinatal depression. \n\n\n\n\n\n\n\n\n\n\n\nHost: Mikael Sellin mikael.sellin@imbim.uu.se\, UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-luisa-hugerth/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230904T151500
DTEND;TZID=Europe/Stockholm:20230904T161500
DTSTAMP:20260511T023612
CREATED:20230822T111554Z
LAST-MODIFIED:20230822T112432Z
UID:10000957-1693840500-1693844100@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Toward Multidimensional Spectral Flow Cytometry: Entering the Quantum Cytometry Domain
DESCRIPTION:J. Paul Robinson\, Professor \n\n\n\nDistinguished Professor of Cytometry \n\n\n\nProfessor of Biomedical Engineering  \n\n\n\nPurdue University\, USA \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\n\n\n\n\nDr. Robinson received his early education at the University of NSW\, Sydney Australia where he received a B.Sc. (Hons)\, M.Sc. and Ph.D. degrees. He was a postdoctoral fellow in the University of Michigan Medical School then a junior faculty in the School of Pathology prior to moving to Purdue University where he was promoted to full professor in 1993. \n\n\n\nDr. Robinson is currently a Distinguished Professor of Cytometry\, and Professor of Biomedical Engineering in the Weldon School of Biomedical Engineering. He also holds appointment in the Purdue Polytechnic Institute\, School of Computer and Information Technology and IU School of Medicine. Dr. Robinson is a Fellow of the American Institute for Medical and Biological Engineering\, a Fellow of the American Association for the Advancement of Science\, a Fellow of the National Academy of Inventors and a Fellow of the Royal Microscipal Society.  Dr. Robinson is a past president of the International Society for Advancement of Cytometry and is the past Editor-in-Chief of Current Protocols in Cytometry. \n\n\n\nHe is an accomplished researcher with over 210 peer-reviewed papers\, over 400 conference presentations\, 10 books\, 15 CDs or DVDs published and over 160 invited international keynote lectures and over 20 issued patents. He formed the Purdue Cytometry Electronic Discussion list in 1989 (http://cyto.purdue.edu/hmarchiv/index.htm) and it continues today with 4500 participants. \n\n\n\nDr. Robinson is the inventor of the key patent on spectral flow cytometry that has been commercialized and morphed into one of the most significant technologies in the field of fluorescence-based single cell detection. In this regard\, together with his colleague Masanobu Yamamoto\, they recently developed the most sensitive\, highest speed single photon detector technology that is likely to have future impact on the field.  He has also worked for many years on detection technologies in the area of food borne pathogens. More recently his group has been focused on developing new approaches to toxin and pathogen detection using laser induced breakdown spectroscopy (LIBS). By combining lanthanide conjugated antibodies as target molecules for toxins\, it is possible to create a rapid detection assay that can be highly multiplexed. \n\n\n\nDr. Robinson is an accomplished mountaineer having summited several of the world’s most difficult mountains including Everest\, (8\,849m\, May 23\, 2009); Manaslu (8\,163m\, Oct 3\, 2008); and McKinley (6\,191m\, Jul 1\, 2008). In 2006 he formed the not-for-profit foundation “Cytometry for Life” (www.cytometyforlife.org) as a mechanism to promote low-cost diagnostics and education primarily in Africa and this organization continues working today to expand education and training in Africa in conjunction with AIBBC (https://www.aibbc-society.org). \n\n\n\n \n\n\n\nToward Multidimensional Spectral Flow Cytometry: Entering the Quantum Cytometry Domain\n\n\n\nFor decades flow cytometry has been a go-to technology for single cell analysis. There are clear advantages for analysis of complex suspensions of cells\, particularly when considering blood cell analysis. The principles for the latest iteration for flow cytometry technology is a spectral approach with is now 2 decades old since we first developed this approach in 2001-2003. Spectral flow cytometry has become the driving technology in the field over the past 5-7 years. What spectral cytometry has brought to the field is a vast increase in multiparameter assay capability now approaching 50 simultaneous fluorescent probes. \n\n\n\nHowever\, what we see as the future of cytometry is often based on our current view of what we presently have. And the question arises can we envisage a technology that is different from what we currently understand and use? This is a difficult question as most of us can’t exactly predict the future! What we do know is there are new tools out there that can become integrated into the field. \n\n\n\nThere is a potential for a 2nd generation spectral technology that we have been working on that may provide many more features that we currently consider when we design our experiments. This presentation will discuss the engineering developments in both current spectral analyzers and spectral cell sorters and outline the next-generation technology that will open up new frontiers in biotechnology research in both research and clinical diagnostics.  The focus will be around how do we approach quantum cytometry? Can we move from the analog world to the digital world – that is to the world where we deal with single photons – the photon being the ultimate digital event?  This requires new sensors for high-speed detection. New sensors require better optics  – more advanced diffraction approaches for light collection than currently available. High-speed sensors demand high speed electronics moving from the megahertz to the gigahertz domain. In all\, moving to quantum cytometry means redefining most of the technology that we have been using for decades.  There is a saying that “you cannot put new wine into old wine skins”! The technical demands for quantum cytometry are far more stringent that current systems allow. However\, when you meet these criteria\, the opportunities for biological detection approaches expands enormously. This presentation will outline a new sensor technology\, new laser/electronics technology and how this will generate datasets that require advanced analytical toolsets demanding AI for potentially automated diagnostics. \n\n\n\n\n\n\n\n\n\n\n\nHost: Masood Kamali-Moghaddam masood.kamali@igp.uu.se\, UU
URL:https://www.scilifelab.se/event/the-svedberg-paul-robinson/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230613T151500
DTEND;TZID=Europe/Stockholm:20230613T161500
DTSTAMP:20260511T023612
CREATED:20230524T093330Z
LAST-MODIFIED:20230524T130749Z
UID:10000897-1686669300-1686672900@www.scilifelab.se
SUMMARY:[The Svedberg seminar] -Physical activity and cancer: Improving causal inference
DESCRIPTION:NOTE THAT THIS SEMINAR IS ON A TUESDAY \n\n\n\nBrigid M. Lynch\, Associate Professor \n\n\n\nDeputy Head\, Cancer Epidemiology Division\, Cancer Council Victoria \n\n\n\nHonorary Principal Fellow\, Centre for Epidemiology and Biostatistics\, Melbourne School of Population and Global Health\, University of Melbourne\, Australia \n\n\n\nBio\n\n\n\n \n\n\n\n\n\n\n\nBrigid Lynch is a cancer epidemiologist whose research focuses on how physical activity is associated with cancer risk\, biological mechanisms underlying risk\, and health outcomes for cancer survivors. Her research interests include applying causal inference methods to help advance the field of physical activity epidemiology. Brigid is a Principal Investigator of the Australian Breakthrough Cancer Study\, an ongoing cohort study of over 50\,000 Australians investigating the role that genes\, lifestyle and environment play in the development of cancer and other diseases. \n\n\n\n \n\n\n\nPhysical activity and cancer: Improving causal inference\n\n\n\nCancer is a leading cause of ill health and mortality; a clear understanding of cancer risk factors is critical to developing effective cancer control strategies. Physical activity has a protective effect for a number of cancers\, however it is – at best – a tangential focus of cancer control agencies around the world. The epidemiological evidence for physical activity and cancer (both in terms of risk and survivorship after diagnosis) is subject to numerous biases\, creating a lack of certainty about causal effects. This presentation will present example studies focused on breast cancer to describe how we can triangulate evidence from different methods to improve causal inference in this field of enquiry. \n\n\n\n\n\n\n\n\n\n\n\nHost: Emerald Heiland\, UU  emerald.heiland@surgsci.uu.se and Hannah Brooke\, UU hannah.brooke@surgsci.uu.se
URL:https://www.scilifelab.se/event/the-svedberg-seminar-physical-activity-and-cancer-improving-causal-inference/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230522T151500
DTEND;TZID=Europe/Stockholm:20230522T161500
DTSTAMP:20260511T023612
CREATED:20230502T162232Z
LAST-MODIFIED:20230503T062420Z
UID:10000874-1684768500-1684772100@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Photo-“click” and photo-“unclick” strategies for spatiotemporal control of substrate immobilization and release
DESCRIPTION:Vladimir Popik \, Professor of Chemistry \n\n\n\nUniversity of Georgia\, USA \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nVladimir Popik received his MSc degree (Chemistry) from the Leningrad State University (1986\, Leningrad\, USSR). His PhD project “Conformational Structure and Photochemical Reactivity of 1\,3-Diazodicarbonyl Compounds” was under the supervision of Prof. Irina Korobitcina and Valery Nikolaev at St. Petersburg State University (same school\, new name). After defending his PhD dissertation in 1990\, he continued as a Research Scientist. In 1992 joined Prof. A. Jerry Kresge group at the University of Toronto as a postdoc then accepted Visiting Research Professor position at the University of Toronto in 1996.  In 1999 Valdimir joined the faculty of the Center for Photochemical Sciences at the Bowling Green State University as an Assistant Professor. In 2005 he was promoted to Associate Professor. In 2006 Vladimir Popik moved to the University of Georgia where he is now Professor of Chemistry. \n\n\n\nAwards: NSF Career Award 2004; Georgia Cancer Coalition Distinguished Scholar 2006; Senior Member of the National Academy of Inventors 2022.Research interests: devlopment of photochemical tools for biochemical\, bioimaging\, and material sciences applications; practical use of two-photon photochemistry; development of novel strategies for click and photoclick ligations; rational design and synthesis light-activated antimitotic agents and gasotransmitteres; investigation of the mechanism of fast reactions.120 Peer-reviewed publications\, (h-index = 41) \, 10 patents. \n\n\n\n \n\n\n\nPhoto-“click” and photo-“unclick” strategies for spatiotemporal control of substrate immobilization and release\n\n\n\nPhotochemical triggering of “click” reactions permits the spatial and temporal control of the derivatization\, labelling\, cross-linking and patterning of various substrates. The absence of potentially detrimental catalysts and/or activating reagents is another beneficial feature of this approach. “Photo-SPAAC” click strategy is based on the photo-decarbonylation of cyclopropenone moiety incorporated into an 8-membered ring. Induction of photo-“click” ligation using two-photon excitation with NIR light (700 – 800 nm or ~ 1100 nm) allows for the 3-dimensional control of the process.Photo-cleavable linkers\, on the other hand\, allow for the spatiotemporal control of the substrate release. \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nHost: Daniel Fürth\, UU  furth@scilifelab.uu.se
URL:https://www.scilifelab.se/event/the-svedberg-seminar-photo-click-and-photo-unclick-strategies/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230508T151500
DTEND;TZID=Europe/Stockholm:20230508T161500
DTSTAMP:20260511T023612
CREATED:20230412T095910Z
LAST-MODIFIED:20230414T114147Z
UID:10000854-1683558900-1683562500@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Global mapping of protein subcellular location offers a new era of comparative and evolutionary cell biology.
DESCRIPTION:Ross Waller \, Professor of Evolutionary Cell Biology \n\n\n\n Department of Biochemistry \n\n\n\nUniversity of Cambridge\, UK \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nRoss Waller completed a PhD in 2000 at the University of Melbourne working on the newly discovered remnant plastid in apicomplexan parasites Plasmodium and Toxoplasma. He undertook postdoctoral training from 2000-3 as a Peter Doherty Fellow working on Leishmania cell biology (University of Melbourne)\, and then from 2003-5 as a Canadian Institutes of Health Research working on molecular evolution in diverse eukaryotes at the University of British Columbia. In 2005 be joined the faculty of the School of Botany\, University of Melbourne\, and in 2013 relocated his laboratory to the Department of Biochemistry\, University of Cambridge. \n\n\n\n \n\n\n\nGlobal mapping of protein subcellular location offers a new era of comparative and evolutionary cell biology\n\n\n\nMost of the diversity of eukaryotic life is represented by unicellular organisms\, and most of this has diverged from well-studied model organisms by over a billion years of evolution. Consequently\, while core eukaryotic cellular and molecular biology is often conserved\, this represents only a small fraction of the molecular diversity\, organisation\, and function of most cells. This\, in turn\, severely constrains our ability to infer the biology of most of eukaryotic life from the better-studied models such as animals and fungi. To address the need for de novo characterisation of cells’ molecular diversity we use a spatial proteomics method called LOPIT that simultaneously captures the steady-state subcellular locations of thousands of proteins. We use these new cellular blueprints as springboards to study the evolutionary processes\, adaptations and trajectories that have contributed to eukaryotic cell diversity\, with particular focus on understanding the apicomplexan parasites and their close algal relatives the dinoflagellates. \n\n\n\n \n\n\n\nHost: Fabien Burki\, UU fabien.burki@ebc.uu.se
URL:https://www.scilifelab.se/event/the-svedberg-seminar-global-mapping-of-protein-subcellular-location/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230424T151500
DTEND;TZID=Europe/Stockholm:20230424T161500
DTSTAMP:20260511T023612
CREATED:20230331T130042Z
LAST-MODIFIED:20230331T130044Z
UID:10000848-1682349300-1682352900@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Copy-Number Changes During Experimental Evolution in Caenorhabditis elegans: Rate\, Fitness Effects and Context-Dependence
DESCRIPTION:VAISHALI KATJU \, Professor \n\n\n\nProgram in Evolutionary Biology \n\n\n\nDepartment of Ecology & Genetics \n\n\n\nUppsala University \n\n\n\n\n\n\n\n\n\n\n\nBio\n\n\n\nProf. Katju is an evolutionary geneticist whose research combines the power of experimental evolution with the model nematode C. elegans and high-throughput genomics to address fundamental questions in biology and evolution regards the rates\, fitness effects and evolutionary dynamics of spontaneous mutations. Her current and future research program is focused on investigating (i) the consequences of spontaneous mutation under varying intensity of selection\, (ii)mitochondrial evolution and the genetic architecture of mitonuclear interactions and (iii) the transcriptional and functional consequences of copy-number changes during adaptation. \n\n\n\nD. Katju earned her Ph.D. in Evolutionary Genetics from Indiana University-Bloomington\, USA in 2004 under the supervision of Dr. Michael Lynch. Following the completion of a National Science Foundation funded Postdoctoral Research Fellowship in Biological Informatics\, she served as a faculty member (Assistant and Associate Professor) in the Department of Biology at the University of New Mexico from 2007-2015. From 2015-2022\, she was a faculty member (Associate and full Professor) in the Department of Veterinary Integrative Biosciences in the College of Veterinary Medicine at Texas A&M University. In 2022\, she joined the Department of Ecology and Genetics at Uppsala University as a Professor. \n\n\n\n \n\n\n\nCopy-Number Changes During Experimental Evolution in Caenorhabditis elegans: Rate\, Fitness Effects and Context-Dependence\n\n\n\n \n\n\n\nThe genomic era has revealed that gene copy-number differences due to gene duplications and deletions are rampant in natural populations. Yet\, base substitutions as a mutational class have dominated the field of evolutionary biology as the main contributor to genetic variation leading to evolution. Herein\, I briefly explore the history of the field\, from the neo-Darwinian synthesis through Ohno’s canonical model for the evolution of gene duplicates and its failure to encapsulate the full complexity of the duplication process. Lastly\, I present results from three long-term experimental evolution experiments in Caenorhabditis elegans that investigate fundamental properties of copy-number variants (CNVs)\, including (i) direct estimates of their rates of origin\, (ii) evidence that CNVs constitute a common mechanism of adaptive genetic change during compensatory evolution\, and (iii) evidence that duplications and deletions of highly transcribed genes are detrimental to fitness and a role for selection against an increase in transcript abundance. \n\n\n\nHost: Leif Andersson leif.andersson@imbim.uu.se  UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-copy-number-changes-during-experimental-evolution-in-caenorhabditis-elegans-rate-fitness-effects-and-context-dependence/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230327T151500
DTEND;TZID=Europe/Stockholm:20230327T161500
DTSTAMP:20260511T023612
CREATED:20230302T102710Z
LAST-MODIFIED:20230316T132039Z
UID:10000823-1679930100-1679933700@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - The Underlying Cause of Human Autoimmune Disease
DESCRIPTION:DAVID A. HAFLER\, MD\, FANA \n\n\n\nWilliam S. and Lois Styles Professor of Neurology and ImmunobiologyChair\, Department of Neurology\, Yale School of MedicineNeurologist-in-Chief\, Yale New Haven HospitalFounding Associate Member\, Broad Institute of MIT and Harvard \n\n\n\nBio\n\n\n\nDavid A. Hafler\, M.D. is the William S. and Lois Stiles Edgerly Professor and Chairman Department ofNeurology and Professor of Immunobiology\, Yale School of Medicine\, and is the Neurologist-in-Chiefof the Yale-New Haven Hospital. He has made seminal discoveries in the pathogenesis of multiplesclerosis and autoimmune diseases including identification of human autoreactive T cells andthe mechanisms that underlie their dysregulation with the discovery of human regulatory T cells.He led the discovery of genetic variants causing. He was awarded the Dystel Prize for MS researchand the 2023 AAI Steinman Award for Human Immunology Research. He is an Honorary Member ofthe Scandinavian Society for Immunology and has been elected to membership in the AmericanSociety of Clinical Investigation\, The Association of American Physicians\, and the National Academy of Medicine. \n\n\n\nThe Underlying Cause of Human Autoimmune Disease\n\n\n\n \n\n\n\nMultiple sclerosis (MS) is a prototypic\, genetically mediated autoimmune disease induced by environmental factors where genetic perturbation of cis-regulatory elements leads to immune dysregulation and generation of myelin reactive T cells secreting inflammatory cytokines. We have identified 233 common allelic variants associated with MS risk where approximately 60% of candidate causal variants map to enhancers and super-enhancers marked by chromatin features in T and B cells. We found that CD4+Foxp3+ Tregs are defective in MS and by performing transcriptomic and epigenomic profiling discovered that upregulation of a primate-specific short PRDM1 isoform (PRDM1-S) induces SGK1 independent from evolutionally conserved long PRDM1\, leading to destabilization of Foxp3 and Treg dysfunction. This aberrant PRDM1-S/SGK1 axis is shared among other autoimmune diseases and it is of interest that SGK-1 is induced by high salt\, an environmental risk factor in MS. Finally\, as suggested by genetic mapping\, B cells play a critical role in the disease and B cell depletion is highly effective in treating early disease. \n\n\n\nHost: Katarina Lundblad katarina.lundblad@neuro.uu.se\, UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-the-underlying-cause-of-human-autoimmune-disease/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230320T151500
DTEND;TZID=Europe/Stockholm:20230320T161500
DTSTAMP:20260511T023612
CREATED:20230227T125936Z
LAST-MODIFIED:20230307T082548Z
UID:10000822-1679325300-1679328900@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - Protein engineering for functional hybrids and biomaterials: applications in biomedicine and technology
DESCRIPTION:Prof. Aitziber Cortajarena \n\n\n\nResearch Professor Scientific DirectorCenter for Cooperative Research in Biomaterials (CIC biomaGUNE) Spain \n\n\n\n\n\n\n\nBio\n\n\n\nProf. Aitziber Cortajarena earned her Ph.D. in Biochemistry from the Universidad del País Vasco in 2002. Then\, she worked on protein design in the group of Dr. Lynne Regan at Yale University\, USA\, as a Postdoctoral Fellow and Associate Research Scientist. She joined IMDEA Nanociencia in 2010 and started her independent research in nanobiotechnology. In 2016\, she joined CIC biomaGUNE as Ikerbasque Research Professor. Currently\, she leads the Biomolecular Nanotechnology group and is Scientific Director at CIC biomaGUNE. \n\n\n\nHer research focuses on protein engineering toward the generation of functional nanostructures and bioinspired materials for applications in nanobiotechnology and nanomedicine. \n\n\n\nProtein engineering for functional hybrids and biomaterials: applications in biomedicine and technology\n\n\n\nProteins are the most versatile biological building blocks\, composed of smaller units called amino acids\, which offer a rich chemisty. The diverse 3D structures of proteins translate into a wide range of functionalities\, making them ideal candidates for use as building blocks in tailored nanofabrication and the creation of novel protein-based functional composites and biomaterials. \n\n\n\nIn our group\, we aim to leverage the potential of engineered proteins as building blocks for the generation of functional nanostructures and bioinspired materials for a wide range of applications in technology and biomedicine. Our goal is to create versatile platforms based on simple protein building blocks\, which can be used to fabricate a variety of protein-based functional composites and biomaterials. \n\n\n\nTo demonstrate the potential of these engineered protein-based systems\, several examples will be shown\, including their use in catalysis\, bioelectronics\, biosensing\, and for the treatment and diagnosis of diseases. \n\n\n\nHost: Antonietta Parracino antonietta.parracino@kemi.uu.se\, UU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-protein-engineering-for-functional-hybrids-and-biomaterials-applications-in-biomedicine-and-technology/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20230118T151500
DTEND;TZID=Europe/Stockholm:20230118T161500
DTSTAMP:20260511T023612
CREATED:20230108T194843Z
LAST-MODIFIED:20230110T091905Z
UID:10000781-1674054900-1674058500@www.scilifelab.se
SUMMARY:[The Svedberg seminar] - High-throughput biology at the organismal level
DESCRIPTION:Jan 18\, at 15:15 in BMC\, C8:301 \n\n\n\nProf. Randall Peterson\,Dean\, College of PharmacyDepartment of Pharmacology and Toxicology\, University of Utah\, USA \n\n\n\nBio\n\n\n\nRandall T. Peterson\, PhD is a chemical biologist whose research utilizes high-throughput screening technologies to discover new drug candidates for cardiovascular and nervous system disorders. Unlike conventional drug discovery programs that utilize simplified\, in vitro assays\, the Peterson lab screens using living zebrafish\, ensuring that the drug candidates discovered are active in vivo. Several of the compounds discovered by the Peterson laboratory have become widely used research tools or preclinical drug candidates.Dr. Peterson received his PhD from Harvard University where he studied as a Howard Hughes Medical Institute predoctoral fellow in the laboratory of Stuart Schreiber.  He completed a postdoctoral fellowship with Mark Fishman at Massachusetts General Hospital. Dr. Peterson spent 14 years as a faculty member at Harvard University where he was the Charles Addison and Elizabeth Ann Sanders Chair in Basic Science at Harvard Medical School\, Scientific Director of the MGH Cardiovascular Research Center\, and Senior Associate Member of the Broad Institute.  In 2017 he moved to the University of Utah as L.S. Skaggs Presidential Endowed Professor and Dean of the College of Pharmacy. \n\n\n\nTitle of the talk: High-throughput biology at the organismal level\n\n\n\nThe impact of high-throughput technologies on biological research has been remarkable. For example\, high-throughput drug screens have revolutionized drug discovery\, and high-throughput CRISPR screens are revolutionizing gene discovery. Notably\, these techniques have focused almost entirely on simple\, in vitro or cell-based assays\, leaving untouched organismal processes such as embryonic development\, physiology\, and animal behavior. These organismal processes are best studied in vivo\, and consequently have not been amenable to high-throughput biology. The Peterson lab is focused on applying high-throughput technologies to such organismal processes and is developing methodologies that enable CRISPR screens and small molecule screens to be applied to organismal processes in zebrafish. Recently\, we have discovered small molecules and genes with novel activities on the cardiovascular\, nervous\, and endocrine systems. I will describe how the compounds and genes were discovered\, what they have taught us about biology\, and how they might find practical or clinical utility. \n\n\n\nHost: Marcel den Hoed marcel.den_hoed@igp.uu.se\, UU
URL:https://www.scilifelab.se/event/the-svedberg-randall-peterson-prof/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221107T151500
DTEND;TZID=Europe/Stockholm:20221107T161500
DTSTAMP:20260511T023612
CREATED:20221025T140529Z
LAST-MODIFIED:20221103T114505Z
UID:10000721-1667834100-1667837700@www.scilifelab.se
SUMMARY:[The Svedberg] - Studying microRNA functions at the single-cell level
DESCRIPTION:MicroRNAs are gene regulatory molecules that play important roles in numerous biological processes including human health. The function of a given microRNA is defined by its selection of target transcripts\, yet current state-of-the-art experimental methods to identify microRNA targets are laborious and require millions of cells – hampering the entry of the microRNA field into the single-cell era. We have overcome these limitations by fusing the microRNA effector protein Argonaute2 to the RNA editing domain of ADAR2\, allowing for the first time the detection of microRNA targets transcriptome-wide in single cells. Our agoTRIBE method reports functional microRNA targets which are additionally supported by evolutionary sequence conservation. As a proof-of-principle\, we study microRNA interactions in single cells\, and find substantial differential targeting across the cell cycle. In addition to presenting this single-cell project\, I will talk about our recent efforts to sequence RNA fragments from ancient animal samples that are preserved in the Siberian permafrost. \n\n\n\nMarc Friedländer is an associate professor at Stockholm University\, Department of Molecular Biosciences. He graduated from his master’s thesis under the supervision of Anders Krogh in Copenhagen and his PhD in the group of Nikolaus Rajewsky in Berlin. He founded his own lab in Stockholm with funding from a SciLifeLab Fellowship and an ERC starting grant. His team is balanced between wet-lab and dry-lab biologists\, and they develop and apply experimental and computational methods to understand gene regulation – with particular emphasis on microRNAs. His lab has studied these molecules in the context of space exposure (a collaboration with NASA); in ancient animal samples preserved in permafrost; and in mammalian single cells. \n\n\n\nWebpage: www.friedlanderlab.org
URL:https://www.scilifelab.se/event/the-svedberg-marc-friedlander-assoc-prof/
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221017T151500
DTEND;TZID=Europe/Stockholm:20221017T161500
DTSTAMP:20260511T023612
CREATED:20221009T184510Z
LAST-MODIFIED:20221009T185208Z
UID:10000710-1666019700-1666023300@www.scilifelab.se
SUMMARY:[The Svedberg] - Manfred Schartl
DESCRIPTION:Developmental Biochemistry\, University of Würzburg\, Germany \n\n\n\nTime: 15:15Venue: C8:305\, BMC\, Uppsala \n\n\n\nHost: Leif Andersson\, Uppsala University \n\n\n\nTitle of the talk: Evolution of sex determination and sex chromosomes in fish \n\n\n\nBio: Prof. Manfred Schartl studied Biology and Chemistry at the University of Giessen\, Germany\, and graduated in Genetics. After postdoctoral research in Giessen and at the NIH in Bethesda he was team leader of a research group from 1985 to 1991 at the Gene Center of the Max Planck Institute for Biochemistry in Martinsried\, Germany. Until 2019 he was full professor and chairman of Physiological Chemistry at the Biocenter of the University of Würzburg. Currently\, he heads a research group as senior professor at the Biocenter and works as scholar in residence at the Xiphophorus Genetic Stock Center at Texas State University in San Marcos. He is member of the German Academy of Sciences\, Leopoldina\, and the European Academy of Sciences\, Academia Europea. He holds an honorary doctorate from the University of Bergen\, Norway.He uses the small aquarium fish biomedical models Xiphophorus and Medaka to understand molecular processes of organ development and their malfunction in disease with a focus on pigment cells and melanoma and another one on sex determination and gonad development. Key to his research is taking an evolutionary perspective to answer these questions on the basis of comparative genomics and molecular biology experimental studies. \n\n\n\nAbstract: Sex determination (SD) is unique biological process in showing an astonishing plasticity of mechanisms. Fish present the greatest variability of SD amongst vertebrates. In the case of genetic SD this is linked to a similarly high variability of sex chromosome differentiation. While in a handful of species with genetic SD the master SD genes have been identified\, their molecular function in directing the development of the bipotential gonad primordium towards testis or ovary is unclear in many cases or incompletely known in the others. To obtain a deeper understanding of this diversity we need a better knowledge of the molecular basis of SD mechanisms and the structure and genetic organization of sex chromosomes across a broad diversity of fish. To identify sex chromosomes and primary SD genes\, we use high throughput RAD-tag marker mapping\, transcriptomics\, Pool-Seq and whole genome sequencing to identify sex-specific chromosomal regions and candidate SD genes in sharks\, sturgeons and teleosts. This led to the identification of sex-specific markers\, allowing to delineate the extent of recombination suppression\, which turned out to be highly variable between species. We identified several species with clear cut XX/XY or ZZ/ZW monofactorial systems but also species with more complex sex-determination systems including species with a mix of genetic SD and environmental SD and species with potential polygenic systems. In species with available genomic resources\, sex-specific markers could be used to assign scaffolds to regions that are supposed to contain the primary SD gene. We identified candidate genes in several species and find that most of them belong to already known factors of the primary SD regulatory network including candidate genes that have not been found so far as being SD genes. We also find that many species harbor very poorly differentiated sex-chromosomes. The SD variety does not follow a phylogenetic pattern\, and turnovers of the genetic SD system from male to female heterogamety and vice versa are frequent in some groups\, making the evolutionary instability of SD a spectacular trait whose biological meaning is not yet understood.
URL:https://www.scilifelab.se/event/the-svedberg-manfred-schartl/
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221013T151500
DTEND;TZID=Europe/Stockholm:20221013T163000
DTSTAMP:20260511T023612
CREATED:20221005T112555Z
LAST-MODIFIED:20221005T113202Z
UID:10000707-1665674100-1665678600@www.scilifelab.se
SUMMARY:[The Svedberg seminar] Prof. Jay Hinton
DESCRIPTION:University of Liverpool\, UK \n\n\n\nTime: 15:15Venue: C8:305\, BMC\, Uppsala \n\n\n\nHost: Siv Andersson\, Uppsala University \n\n\n\nProf. Jay Hinton is Professor of Microbial Pathogenesis at the University of Liverpool. Prof. Prof. Hinton has developed RNA-seq-based approaches for studying gene expression of in vitro-grown and intra-macrophage bacteria. He is currently using functional genomics methods to understand how new Salmonella pathovariants are causing endemic bloodstream infections across sub-Saharan Africa. This disease has killed around 500\,000 people over the last decade. \n\n\n\nTitle of the talk: How has Salmonella become so dangerous in Africa?\n\n\n\nWith 3.4 million infections each year\, invasive non-Typhoidal Salmonella (iNTS) is a major cause of illness worldwide. In Sub-Saharan Africa\, bloodstream infections involving iNTS Salmonella enterica serovar Typhimurium are causing ~49\,000 deaths annually. Co-infection with HIV or malaria in adults\, and a young age (<5 years) are known risk factors. The main causative agent of iNTS is a pathovariant of Salmonella Typhimurium called ST313\, which is multi-drug resistant and closely-related to the ST19 type of Salmonella responsible for gastroenteritis globally. \n\n\n\nUsing a combination of comparative genomics and comparative transcriptomics\,we discovered phenotypic differences that distinguish African from global Salmonella pathovariants (Canals et al.\, 2019; Honeycutt et al.\, 2020). \n\n\n\nOur analysis led us to identify a single core genome SNP responsible for the up-regulation of a single promoter in strain D23580 that controlled the expression of a Salmonella virulence factor (Hammarlöf et al.\, 2018)\, and offers part of the explanation of the pan-African epidemic of bloodstream infection.All of the Salmonella transcriptomic data we have generated are now available online in a user-friendly website that allows intra-strain and inter-strain comparisons of gene expression between African and global pathovariants ofS. Typhimurium: https://tinyurl.com/SalComD23580 \n\n\n\nMost recently\, we used the combined power of genomics and epidemiology and thousands of historical and contemporary Salmonella isolates to understand the precise evolutionary trajectory of the S. Typhimurium ST313 pathogen in Africa. We identified a series of novel genome degradation events that impacted upon the function of Salmonella genes required for colonisation of the mammalian gut\, providing evidence of niche adaptation and the continuing evolution of ST313 (Pulford et al.\, 2021). \n\n\n\nI will summarise the evolutionary pathway of invasive S. Typhimurium across Africa\, and explain the value of an integrated functional genomic analysis for understanding how bacterial pathogens cause disease. \n\n\n\nReferencesCanals et al. (2019) Adding function to genome of African Salmonella Typhimurium ST313. PLoS Biology 17(1): e3000059. DOI: 10.1371/journal.pbio.3000059 \n\n\n\nHammarlöf et al. (2018) Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella. PNAS 115: E2614 – E2623. \n\n\n\nDOI: 10.1073/pnas.1714718115 \n\n\n\nHoneycutt et al. Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa. PLoS Pathog. 2020 16:e1008763. DOI: 10.1371/journal.ppat.1008763 \n\n\n\nPulford et al. (2021) Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa. Nature Microbiology 6: 327–338. \n\n\n\nDOI:10.1038/s41564-020-00836-1
URL:https://www.scilifelab.se/event/the-svedberg-seminar-prof-jay-hinton/
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220523T151500
DTEND;TZID=Europe/Stockholm:20220523T161500
DTSTAMP:20260511T023612
CREATED:20220422T114620Z
LAST-MODIFIED:20220523T063854Z
UID:10000592-1653318900-1653322500@www.scilifelab.se
SUMMARY:The Svedberg seminar: Tanja Slotte
DESCRIPTION:Tanja Slotte\, Assoc. Prof.Stockholm University\, Sweden \n\n\n\nRegister and get the Link\n\n\n\nAssoc. Prof. Tanja Slotte is a population geneticist who is interested in the genetic causes and genomic consequences of plant mating system shifts and the evolution of mating system supergenes. She received her PhD from Uppsala University in 2007\, followed by a postdoc at University of Toronto. She started her own group at Uppsala University in 2010 and moved to Stockholm University to take up a SciLifeLab Fellow position in 2014. She is currently Associate Professor in Ecological Genomics at Stockholm University. \n\n\n\nTitle of the seminar: Sequencing the supergene that governs Darwin’s different forms of flower\n\n\n\nSupergenes are responsible for a wide variety of balanced polymorphisms in nature\, yet our understanding of their origins and evolution remains incomplete. The reciprocal placement of stigmas and anthers in pin and thrum floral morphs of distylous species constitutes an iconic example of a balanced polymorphism governed by a supergene. Recent studies have shown that the Primula distyly S-locus supergene is hemizygous due to structural variation at the supergene. If this genetic architecture is common to other distyly supergenes\, it could have major implications for the evolution and loss of distyly. To shed further light on this question we have characterized the genetic architecture and evolution of the distyly supergene in Linum\, one of the plant systems where Dawin first described distyly. We have generated multiple high-quality genome assemblies of Linum species as a genomic framework for evolutionary studies. Here\, we leverage this framework to identify the distyly S-locus supergene and study its evolution and expression. Our results show that hemizygosity and thrum-specific expression are major features of the Linum distyly supergene\, and suggest that the supergene has arisen in a stepwise manner. Our findings demonstrate remarkable convergence in the genetic architecture\, origin and evolution of the distyly supergene among systems with independently derived distyly\, and shed light on the evolution of the classic supergene that governs Darwin’s “different forms of flowers”.
URL:https://www.scilifelab.se/event/the-svedberg-seminar-tanja-slotte/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/Picture1-The-Svedberg-edited.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220516T171500
DTEND;TZID=Europe/Stockholm:20220516T181500
DTSTAMP:20260511T023612
CREATED:20220422T112304Z
LAST-MODIFIED:20220505T130333Z
UID:10000591-1652721300-1652724900@www.scilifelab.se
SUMMARY:The Svedberg seminar: Simon Elsässer
DESCRIPTION:Register and get the link here\n\n\n\n\n\nSimon Elsässer is  Associate Professor at Karolinska Institutet\, Department of Medical Biochemistry and Biophysics. He has studied at University of Tübingen and Harvard University\, and received his Ph.D. from The Rockefeller University in 2012. He has performed postdoctoral research at MRC Laboratory of Molecular Biology and was recruited to Karolinska Institutet as a SciLifeLab Fellow in 2015. His research combines synthetic biology methods to probe and manipulate proteins in the living cell with quantitative ‘omics readouts\, focusing on stem cells\, gene expression regulation and epigenomics. \n\n\n\nTitle of the seminar: Exploring the dynamics of the pluripotent epigenome and lineage choice in development\n\n\n\n \n\n\n\nShort Abstract: \n\n\n\nThe first lineage choice made in human embryo development separates trophectoderm from the inner cell mass\, which proceeds to form the pluripotent epiblast and primitive endoderm. We discovered that Polycomb repressive complex 2 (PRC2) maintains naïve pluripotency and restricts an intrinsic capacity of pre-implantation pluripotent stem cells to give rise to extraembryonic lineages. Through quantitative ChIP-seq and single-cell transcriptomics\, we demonstrate that PRC2-mediated repression provides a highly adaptive mechanism to restrict lineage potential during early human development.Webpage: http://www.elsaesserlab.org
URL:https://www.scilifelab.se/event/simon-elsasser/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/Picture1-The-Svedberg-edited.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220509T151500
DTEND;TZID=Europe/Stockholm:20220509T160000
DTSTAMP:20260511T023612
CREATED:20220502T101150Z
LAST-MODIFIED:20220502T101852Z
UID:10000598-1652109300-1652112000@www.scilifelab.se
SUMMARY:The Svedberg seminar: Daniel Fürth
DESCRIPTION:Assistent Professor\, SciLifeLab Fellow at Uppsala University \n\n\n\nHybrid event: Trippelrummet\, Navet\, BMC and Online \n\n\n\n\n\n\n\n\n\nRegister here\n\n\n\nDr. Daniel Fürth completed his Ph.D. in neuroscience at Karolinska Institutet\, working on mesoscale connectomics using modified rabies virus tracing\, then postdoctoral work in RNA biology and method development at Cold Spring Harbor Laboratory\, Cancer Center\, New York. At Cold Spring Harbor he focused on enabling functional RNA genomics in situ at subcellular single-molecule resolution. Dr. Fürth’s expertise as a leader in both wet and dry lab neuroscience is internationally recognized with a Brain & Behavior Research Foundation NARSAD Young Investigator Award and computational funding from the Chan Zuckerberg Initiative. Dr. Fürth’s lab studies how information is stored\, processed and transmitted between cells. The focus is to find hitherto unknown mechanisms that can transfer symbolic information between cells. Identification of such transmission would enable us to read and write those messages.  \n\n\n\nTitle of the seminar: From in situ to in vivo sequencing\n\n\n\nUnbiased investigation of subcellular RNA localization and its control in vivo remains challenging. Current hybridization-based methods cannot differentiate small regulatory variants\, whilein situ sequencing is limited by short reads. We solved these problems using a bidirectional sequencing chemistry to efficiently image transcript-specific barcodes in situ\, which are then extracted and assembled into longer reads using NGS. Specific cis-regulatory elements usually found in mRNA 3′UTRs mediate RNA localization. Reverse transcription was primed towards the 3’UTR/polyA-tail junction in developing Drosophila and we discovered that in situ cDNA synthesis stalls just downstream of RNA-binding protein crosslink sites\, resulting in truncated cDNAs near RNA-binding protein motifs. We utilized these stop signatures to spatially map cis-regulatory motifs in specific alternative polyadenylation (APA) isoforms. A subset of genes displayed expression of two or more APA isoforms with distinct localization in situ\, to which we could identify their putative trans-acting partners. We validated our findings using both iCLIP-seq and targeted clampFISH probes. Our platform\, therefore\, provides a powerful way to discover novel RNA variants and protein interactions and their localization in situ. Lastly\, I’ll present recent developments of a fluorogenic and non-enzymatic sequencing chemistry capable of sequencing single molecules directly in live cells with subcellular precision.
URL:https://www.scilifelab.se/event/the-svedberg-seminar-daniel-furth/
LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/Picture1-The-Svedberg-edited.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220502T151500
DTEND;TZID=Europe/Stockholm:20220502T161500
DTSTAMP:20260511T023612
CREATED:20220422T104856Z
LAST-MODIFIED:20220422T111337Z
UID:10000590-1651504500-1651508100@www.scilifelab.se
SUMMARY:The use of systems biology in treatment of liver diseases
DESCRIPTION:Adil Mardinoglu\, Assoc. Prof.KTH SwendenKing s College London\, UK\n\n\n\n \n\n\n\nRegister here to get the zoom link\n\n\n\nAssoc. Prof. Adil Mardinoglu is an expert in the field of Systems Medicine\, Systems Biology\, Computational Biology and Bioinformatics. He lead a team of 25 researchers working in the area of computational biology\, experimental biology and drug development to develop new treatment strategies for Metabolic diseases\, Neurodegenerative diseases and certain type of cancers  \n\n\n\n Abstract: Biological networks can provide a scaffold for studying biological pathways operating in the liver in connection with disease development in a systematic manner. In my presentation\, I will present our recent work where biological networks have been employed to identify the reprogramming in liver physiology in response to NASH/NAFLD. I will further discuss how this mechanistic modelling approach can contribute to the discovery of biomarkers and identification of drug targets which may lead to design of targeted and effective personalized medicine. \n\n\n\nWebpage: https://sysmedicine.com/
URL:https://www.scilifelab.se/event/adil-mardinoglu/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220411T151500
DTEND;TZID=Europe/Stockholm:20220411T161500
DTSTAMP:20260511T023612
CREATED:20220315T160745Z
LAST-MODIFIED:20220404T080634Z
UID:10000558-1649690100-1649693700@www.scilifelab.se
SUMMARY:Decreased levels of oxygen radicals cause autoimmune disease.
DESCRIPTION:Prof. Rikard Holmdahl \n\n\n\nKarolinska Institute\, Sweden \n\n\n\nRegister HERE\n\n\n\nRikard Holmdahl made his PhD (1985) and MD (1987) at Uppsala University. Professor in medical inflammation research Lund University 93-07. Professor at Karolinska Institute from 2008 \n\n\n\n\n\n\n\nVenue: Hybrid meeting – Trippelrummet\, Navet and zoom \n\n\n\n\n\n\n\n\n\n \n\n\n\nTitle of the seminar: Finding and understanding genes associated with common diseases; decreased levels of oxygen radicals cause autoimmune disease\n\n\n\nA long-standing challenge is to understand which genes that cause common complex diseases\, such as rheumatoid arthritis\, atherosclerosis or cancer\, and thereby understand the disease causes. However\, even though we know the human sequence and can genotype millions of individuals it is very difficult to conclusively identify the single nucleotide variants that cause the diseases. We have taken another approach through animal models. Both genetics and diseases show similarities with humans\, and we have shown that it is possible to not only identify the loci associated with disease but also exactly position the polymorphic nucleotides for common autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).  \n\n\n\nI will focus on the first gene that we cloned\, Ncf1\, which regulate immune tolerance through different levels of oxygen radicals\, or more precisely hydrogen peroxide. It is the major gene causing SLE and is important in Sjögren’s syndrome and RA and most likely most autoimmune disease. \n\n\n\nTo understand the role of Ncf1 is also complicated as peroxide seem to regulate many different pathways leading to autoimmune diseases. I will discuss how we think it regulates RA and SLE but also how it could explain our normal behaviour\, thus explaining why Ncf1 variants are common in both rat and human population. \n\n\n\nRead more about ikard Holmdahl´s research http://ki.se/en/mbb/research-division-of-medical-inflammation-research
URL:https://www.scilifelab.se/event/decreased-levels-of-oxygen-radicals-cause-autoimmune-disease/
LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220328T151500
DTEND;TZID=Europe/Stockholm:20220328T161500
DTSTAMP:20260511T023612
CREATED:20220307T155747Z
LAST-MODIFIED:20220315T155833Z
UID:10000546-1648480500-1648484100@www.scilifelab.se
SUMMARY:Digital twins for predictive\, preventive and personalised medicine
DESCRIPTION:Prof. Mikael Benson\n\n\n\nLinköping University\, Sweden \n\n\n\n\n\nRegister HERE\n\n\n\n\n\n\n\n\n\nMikael Benson is a professor of pediatrics\, whose team aims to construct digital twins of individual patients for predictive\, preventive and personalised medicine \n\n\n\nDigital twins for predictive\, preventive and personalised medicine\n\n\n\nDigital twins are high-resolution models of individual patients. Each twin is computationally treated with thousands of drugs to find optimal drug or drugs for the patient: The twins are constructed by combining omics data down to the single cell level with routine clinical data. \n\n\n\nHost: Prof. Olli Kallioniemi \n\n\n\nRead more about the swedish digital twin consortium
URL:https://www.scilifelab.se/event/the-svedberg-seminar-prof-mikael-benson/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220314T151500
DTEND;TZID=Europe/Stockholm:20220314T161500
DTSTAMP:20260511T023612
CREATED:20220307T092733Z
LAST-MODIFIED:20220309T145506Z
UID:10000545-1647270900-1647274500@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Prof. Claudia Langenberg
DESCRIPTION:Berlin Institute of Health at Charité Universitätsmedizin\, Berlin\, Germany and MRC Epidemiology Unit\, University of Cambridge\, UK \n\n\n\nLink to zoom meeting\n\n\n\n\n\n\n\n\n\n\n\n\n\nFrom molecules to health records: utility of omics at population scale\n\n\n\nApplication of different omic technologies is now feasible at population scale. This talk will present examples of how the integration of different omics in large patient and population studies can help to predict disease risk\, understand mechanisms\, and reveal shared connections between different diseases. \n\n\n\nShort bio: Claudia Langenberg is Professor of Computational Medicine at the Berlin Institute of Health at Charité (BIH) and MRC Investigator and Programme Leader at the MRC Epidemiology Unit at the University of Cambridge. Her research is focused on the genetic basis of metabolic control\, and her team studies its effects on health through integration of molecular with clinical data in large-scale patient and population-based studies. \n\n\n\nOmniScience\n\n\n\nComputational Medicine at Berlin Institute of Health\n\n\n\n \n\n\n\nHost: Jochen Schwenk\, KTH/SciLifeLab
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-prof-claudia-langenberg/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20211122T151500
DTEND;TZID=Europe/Stockholm:20211122T163000
DTSTAMP:20260511T023612
CREATED:20211110T141705Z
LAST-MODIFIED:20211122T105625Z
UID:10000484-1637594100-1637598600@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Prof. Tuuli Lappalainen
DESCRIPTION:Science for Life Laboratory\, Department of Gene Technology\, KTH Royal Institute of Technology\, Stockholm\, Sweden \n\n\n\nNew York Genome Center\, New York\, USA \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nTuuli Lappalainen is a Professor in Genomics at KTH Royal Institute of Technology\, an Associate Faculty Member at the New York Genome Center\, and the Director of the National Genomics Infrastructure of SciLifeLab. She is also an Adjunct Professor at the Department of Systems Biology at Columbia University. \n\n\n\nHer research focuses on functional genetic variation in human populations and its contribution to traits and diseases. She has pioneered the intergration of large-scale genome and transcriptome sequencing data to understand how genetic variation affects gene expression\, providing insight to cellular mechanisms underlying genetic risk for disease. \n\n\n\n\n\n\n\nFunctional variation in the human genome: lessons from the transcriptome\n\n\n\nDetailed characterization of molecular and cellular effects of genetic variants is essential for understanding biological processes that underlie genetic associations to disease. A particularly scalable approach has been linking genetic variants to effects in the transcriptome that is amenable for scalable measurements in human populations and in experimental settings\, including at the single cell level. Our multi-omic analysis in human cohorts in the TOPMed project has identified genetic and environmental effects on molecular variation together with their complex interplay with clinical phenotypes. Furthermore\, in this talk I will discuss how CRISPRi silencing of regulatory elements followed by single-cell analysis provides novel insights of mechanisms of genetic associations to complex traits. Altogether\, these diverse approaches for integration genome and transcriptome data uncover functional genetic architecture of human traits\, and enhances our understanding of both basic biology and precision medicine applications. \n\n\n\nHost: Jessica Nordlund\, Uppsala University
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-tuuli-lappalainen/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20211108T151500
DTEND;TZID=Europe/Stockholm:20211108T163000
DTSTAMP:20260511T023612
CREATED:20211005T080424Z
LAST-MODIFIED:20211005T080541Z
UID:10000460-1636384500-1636389000@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Ass. Prof. Maria Kasper
DESCRIPTION:Karolinska Institutet\, Department of Cell and Molecular Biology\, Sweden \n\n\n\nLINK TO SEMINAR   \n\n\n\n\n\n\n\n\n\nMaria Kasper is Associate Professor at the Karolinska Institutet in Stockholm\, Department of Cell and Molecular Biology. She received her PhD at the University of Salzburg in genetics\, with the majors in human genetics and molecular tumor biology. She came to Sweden in 2007\, where she spent a fruitful postdoctoral time in Rune Toftgårds lab\, and in 2013 she started her own lab focusing on skin\, stem cell biology and single-cell RNA sequencing. In 2016\, her lab pioneered the use of single-cell transcriptomics in the organ skin and has overall contributed with important work in skin biology and regenerative medicine. Maria has received a number of national recognitions such as the Framtidens Forskningsledare from SSF\, Ragnar Söderberg Fellow in Medicine and the CIMED young investigator award\, as well as the prestigious international LEO Foundation Gold Award for outstanding skin research. Since 2020\, she also coordinates together with Fiona Watt the Human Cell Atlas bionetwork for the organ skin. \n\n\n\nDecoding the molecular anatomy of skin\n\n\n\nSkin architecture and its function are determined by a rich variety of epithelial\, mesenchymal and immune cells that together orchestrate skin homeostasis\, including cyclical hair growth and barrier function. Previously\, my lab generated a comprehensive molecular and spatial atlas of epithelial and stromal cells during hair growth and rest. These studies revealed underlying molecular programs during progenitor-cell commitment and lineage differentiation\, as well as spatiotemporal fibroblast heterogeneity and potential epithelial-stromal interactions. The importance of cell-type specific signaling during homeostasis\, and the unrecognized potential of cell-type restricted signaling-changes were exemplified by our recent discovery of how to induce new hair follicles in adult mouse skin by modulating a single signaling pathway. Building on the molecular knowledge and computational skills gained\, our ongoing work uncovers new insights in the molecular orchestration of embryonic hair follicle development\, as well as the coordination of adult skin stem cell differentiation by tissue resident immune cells.Host: Gabriella Lindgren\, SLU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-ass-prof-maria-kasper/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
END:VCALENDAR