BEGIN:VCALENDAR VERSION:2.0 PRODID:-//SciLifeLab - ECPv6.15.20//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:SciLifeLab X-ORIGINAL-URL:https://www.scilifelab.se X-WR-CALDESC:Events for SciLifeLab REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20200329T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20201025T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20210328T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20211031T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20220327T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20221030T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20230326T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20231029T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230522T151500 DTEND;TZID=Europe/Stockholm:20230522T161500 DTSTAMP:20260511T032415 CREATED:20230502T162232Z LAST-MODIFIED:20230503T062420Z UID:10000874-1684768500-1684772100@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Photo-“click” and photo-“unclick” strategies for spatiotemporal control of substrate immobilization and release DESCRIPTION:Vladimir Popik \, Professor of Chemistry \n\n\n\nUniversity of Georgia\, USA \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nVladimir Popik received his MSc degree (Chemistry) from the Leningrad State University (1986\, Leningrad\, USSR). His PhD project “Conformational Structure and Photochemical Reactivity of 1\,3-Diazodicarbonyl Compounds” was under the supervision of Prof. Irina Korobitcina and Valery Nikolaev at St. Petersburg State University (same school\, new name). After defending his PhD dissertation in 1990\, he continued as a Research Scientist. In 1992 joined Prof. A. Jerry Kresge group at the University of Toronto as a postdoc then accepted Visiting Research Professor position at the University of Toronto in 1996. In 1999 Valdimir joined the faculty of the Center for Photochemical Sciences at the Bowling Green State University as an Assistant Professor. In 2005 he was promoted to Associate Professor. In 2006 Vladimir Popik moved to the University of Georgia where he is now Professor of Chemistry. \n\n\n\nAwards: NSF Career Award 2004; Georgia Cancer Coalition Distinguished Scholar 2006; Senior Member of the National Academy of Inventors 2022.Research interests: devlopment of photochemical tools for biochemical\, bioimaging\, and material sciences applications; practical use of two-photon photochemistry; development of novel strategies for click and photoclick ligations; rational design and synthesis light-activated antimitotic agents and gasotransmitteres; investigation of the mechanism of fast reactions.120 Peer-reviewed publications\, (h-index = 41) \, 10 patents. \n\n\n\n \n\n\n\nPhoto-“click” and photo-“unclick” strategies for spatiotemporal control of substrate immobilization and release\n\n\n\nPhotochemical triggering of “click” reactions permits the spatial and temporal control of the derivatization\, labelling\, cross-linking and patterning of various substrates. The absence of potentially detrimental catalysts and/or activating reagents is another beneficial feature of this approach. “Photo-SPAAC” click strategy is based on the photo-decarbonylation of cyclopropenone moiety incorporated into an 8-membered ring. Induction of photo-“click” ligation using two-photon excitation with NIR light (700 – 800 nm or ~ 1100 nm) allows for the 3-dimensional control of the process.Photo-cleavable linkers\, on the other hand\, allow for the spatiotemporal control of the substrate release. \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nHost: Daniel Fürth\, UU furth@scilifelab.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-photo-click-and-photo-unclick-strategies/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230508T151500 DTEND;TZID=Europe/Stockholm:20230508T161500 DTSTAMP:20260511T032415 CREATED:20230412T095910Z LAST-MODIFIED:20230414T114147Z UID:10000854-1683558900-1683562500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Global mapping of protein subcellular location offers a new era of comparative and evolutionary cell biology. DESCRIPTION:Ross Waller \, Professor of Evolutionary Cell Biology \n\n\n\n Department of Biochemistry \n\n\n\nUniversity of Cambridge\, UK \n\n\n\n \n\n\n\n \n\n\n\nBio\n\n\n\nRoss Waller completed a PhD in 2000 at the University of Melbourne working on the newly discovered remnant plastid in apicomplexan parasites Plasmodium and Toxoplasma. He undertook postdoctoral training from 2000-3 as a Peter Doherty Fellow working on Leishmania cell biology (University of Melbourne)\, and then from 2003-5 as a Canadian Institutes of Health Research working on molecular evolution in diverse eukaryotes at the University of British Columbia. In 2005 be joined the faculty of the School of Botany\, University of Melbourne\, and in 2013 relocated his laboratory to the Department of Biochemistry\, University of Cambridge. \n\n\n\n \n\n\n\nGlobal mapping of protein subcellular location offers a new era of comparative and evolutionary cell biology\n\n\n\nMost of the diversity of eukaryotic life is represented by unicellular organisms\, and most of this has diverged from well-studied model organisms by over a billion years of evolution. Consequently\, while core eukaryotic cellular and molecular biology is often conserved\, this represents only a small fraction of the molecular diversity\, organisation\, and function of most cells. This\, in turn\, severely constrains our ability to infer the biology of most of eukaryotic life from the better-studied models such as animals and fungi. To address the need for de novo characterisation of cells’ molecular diversity we use a spatial proteomics method called LOPIT that simultaneously captures the steady-state subcellular locations of thousands of proteins. We use these new cellular blueprints as springboards to study the evolutionary processes\, adaptations and trajectories that have contributed to eukaryotic cell diversity\, with particular focus on understanding the apicomplexan parasites and their close algal relatives the dinoflagellates. \n\n\n\n \n\n\n\nHost: Fabien Burki\, UU fabien.burki@ebc.uu.se URL:https://www.scilifelab.se/event/the-svedberg-seminar-global-mapping-of-protein-subcellular-location/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230424T151500 DTEND;TZID=Europe/Stockholm:20230424T161500 DTSTAMP:20260511T032415 CREATED:20230331T130042Z LAST-MODIFIED:20230331T130044Z UID:10000848-1682349300-1682352900@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Copy-Number Changes During Experimental Evolution in Caenorhabditis elegans: Rate\, Fitness Effects and Context-Dependence DESCRIPTION:VAISHALI KATJU \, Professor \n\n\n\nProgram in Evolutionary Biology \n\n\n\nDepartment of Ecology & Genetics \n\n\n\nUppsala University \n\n\n\n\n\n\n\n\n\n\n\nBio\n\n\n\nProf. Katju is an evolutionary geneticist whose research combines the power of experimental evolution with the model nematode C. elegans and high-throughput genomics to address fundamental questions in biology and evolution regards the rates\, fitness effects and evolutionary dynamics of spontaneous mutations. Her current and future research program is focused on investigating (i) the consequences of spontaneous mutation under varying intensity of selection\, (ii)mitochondrial evolution and the genetic architecture of mitonuclear interactions and (iii) the transcriptional and functional consequences of copy-number changes during adaptation. \n\n\n\nD. Katju earned her Ph.D. in Evolutionary Genetics from Indiana University-Bloomington\, USA in 2004 under the supervision of Dr. Michael Lynch. Following the completion of a National Science Foundation funded Postdoctoral Research Fellowship in Biological Informatics\, she served as a faculty member (Assistant and Associate Professor) in the Department of Biology at the University of New Mexico from 2007-2015. From 2015-2022\, she was a faculty member (Associate and full Professor) in the Department of Veterinary Integrative Biosciences in the College of Veterinary Medicine at Texas A&M University. In 2022\, she joined the Department of Ecology and Genetics at Uppsala University as a Professor. \n\n\n\n \n\n\n\nCopy-Number Changes During Experimental Evolution in Caenorhabditis elegans: Rate\, Fitness Effects and Context-Dependence\n\n\n\n \n\n\n\nThe genomic era has revealed that gene copy-number differences due to gene duplications and deletions are rampant in natural populations. Yet\, base substitutions as a mutational class have dominated the field of evolutionary biology as the main contributor to genetic variation leading to evolution. Herein\, I briefly explore the history of the field\, from the neo-Darwinian synthesis through Ohno’s canonical model for the evolution of gene duplicates and its failure to encapsulate the full complexity of the duplication process. Lastly\, I present results from three long-term experimental evolution experiments in Caenorhabditis elegans that investigate fundamental properties of copy-number variants (CNVs)\, including (i) direct estimates of their rates of origin\, (ii) evidence that CNVs constitute a common mechanism of adaptive genetic change during compensatory evolution\, and (iii) evidence that duplications and deletions of highly transcribed genes are detrimental to fitness and a role for selection against an increase in transcript abundance. \n\n\n\nHost: Leif Andersson leif.andersson@imbim.uu.se UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-copy-number-changes-during-experimental-evolution-in-caenorhabditis-elegans-rate-fitness-effects-and-context-dependence/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230327T151500 DTEND;TZID=Europe/Stockholm:20230327T161500 DTSTAMP:20260511T032415 CREATED:20230302T102710Z LAST-MODIFIED:20230316T132039Z UID:10000823-1679930100-1679933700@www.scilifelab.se SUMMARY:[The Svedberg seminar] - The Underlying Cause of Human Autoimmune Disease DESCRIPTION:DAVID A. HAFLER\, MD\, FANA \n\n\n\nWilliam S. and Lois Styles Professor of Neurology and ImmunobiologyChair\, Department of Neurology\, Yale School of MedicineNeurologist-in-Chief\, Yale New Haven HospitalFounding Associate Member\, Broad Institute of MIT and Harvard \n\n\n\nBio\n\n\n\nDavid A. Hafler\, M.D. is the William S. and Lois Stiles Edgerly Professor and Chairman Department ofNeurology and Professor of Immunobiology\, Yale School of Medicine\, and is the Neurologist-in-Chiefof the Yale-New Haven Hospital. He has made seminal discoveries in the pathogenesis of multiplesclerosis and autoimmune diseases including identification of human autoreactive T cells andthe mechanisms that underlie their dysregulation with the discovery of human regulatory T cells.He led the discovery of genetic variants causing. He was awarded the Dystel Prize for MS researchand the 2023 AAI Steinman Award for Human Immunology Research. He is an Honorary Member ofthe Scandinavian Society for Immunology and has been elected to membership in the AmericanSociety of Clinical Investigation\, The Association of American Physicians\, and the National Academy of Medicine. \n\n\n\nThe Underlying Cause of Human Autoimmune Disease\n\n\n\n \n\n\n\nMultiple sclerosis (MS) is a prototypic\, genetically mediated autoimmune disease induced by environmental factors where genetic perturbation of cis-regulatory elements leads to immune dysregulation and generation of myelin reactive T cells secreting inflammatory cytokines. We have identified 233 common allelic variants associated with MS risk where approximately 60% of candidate causal variants map to enhancers and super-enhancers marked by chromatin features in T and B cells. We found that CD4+Foxp3+ Tregs are defective in MS and by performing transcriptomic and epigenomic profiling discovered that upregulation of a primate-specific short PRDM1 isoform (PRDM1-S) induces SGK1 independent from evolutionally conserved long PRDM1\, leading to destabilization of Foxp3 and Treg dysfunction. This aberrant PRDM1-S/SGK1 axis is shared among other autoimmune diseases and it is of interest that SGK-1 is induced by high salt\, an environmental risk factor in MS. Finally\, as suggested by genetic mapping\, B cells play a critical role in the disease and B cell depletion is highly effective in treating early disease. \n\n\n\nHost: Katarina Lundblad katarina.lundblad@neuro.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-the-underlying-cause-of-human-autoimmune-disease/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230320T151500 DTEND;TZID=Europe/Stockholm:20230320T161500 DTSTAMP:20260511T032415 CREATED:20230227T125936Z LAST-MODIFIED:20230307T082548Z UID:10000822-1679325300-1679328900@www.scilifelab.se SUMMARY:[The Svedberg seminar] - Protein engineering for functional hybrids and biomaterials: applications in biomedicine and technology DESCRIPTION:Prof. Aitziber Cortajarena \n\n\n\nResearch Professor Scientific DirectorCenter for Cooperative Research in Biomaterials (CIC biomaGUNE) Spain \n\n\n\n\n\n\n\nBio\n\n\n\nProf. Aitziber Cortajarena earned her Ph.D. in Biochemistry from the Universidad del País Vasco in 2002. Then\, she worked on protein design in the group of Dr. Lynne Regan at Yale University\, USA\, as a Postdoctoral Fellow and Associate Research Scientist. She joined IMDEA Nanociencia in 2010 and started her independent research in nanobiotechnology. In 2016\, she joined CIC biomaGUNE as Ikerbasque Research Professor. Currently\, she leads the Biomolecular Nanotechnology group and is Scientific Director at CIC biomaGUNE. \n\n\n\nHer research focuses on protein engineering toward the generation of functional nanostructures and bioinspired materials for applications in nanobiotechnology and nanomedicine. \n\n\n\nProtein engineering for functional hybrids and biomaterials: applications in biomedicine and technology\n\n\n\nProteins are the most versatile biological building blocks\, composed of smaller units called amino acids\, which offer a rich chemisty. The diverse 3D structures of proteins translate into a wide range of functionalities\, making them ideal candidates for use as building blocks in tailored nanofabrication and the creation of novel protein-based functional composites and biomaterials. \n\n\n\nIn our group\, we aim to leverage the potential of engineered proteins as building blocks for the generation of functional nanostructures and bioinspired materials for a wide range of applications in technology and biomedicine. Our goal is to create versatile platforms based on simple protein building blocks\, which can be used to fabricate a variety of protein-based functional composites and biomaterials. \n\n\n\nTo demonstrate the potential of these engineered protein-based systems\, several examples will be shown\, including their use in catalysis\, bioelectronics\, biosensing\, and for the treatment and diagnosis of diseases. \n\n\n\nHost: Antonietta Parracino antonietta.parracino@kemi.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-seminar-protein-engineering-for-functional-hybrids-and-biomaterials-applications-in-biomedicine-and-technology/ LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20230118T151500 DTEND;TZID=Europe/Stockholm:20230118T161500 DTSTAMP:20260511T032415 CREATED:20230108T194843Z LAST-MODIFIED:20230110T091905Z UID:10000781-1674054900-1674058500@www.scilifelab.se SUMMARY:[The Svedberg seminar] - High-throughput biology at the organismal level DESCRIPTION:Jan 18\, at 15:15 in BMC\, C8:301 \n\n\n\nProf. Randall Peterson\,Dean\, College of PharmacyDepartment of Pharmacology and Toxicology\, University of Utah\, USA \n\n\n\nBio\n\n\n\nRandall T. Peterson\, PhD is a chemical biologist whose research utilizes high-throughput screening technologies to discover new drug candidates for cardiovascular and nervous system disorders. Unlike conventional drug discovery programs that utilize simplified\, in vitro assays\, the Peterson lab screens using living zebrafish\, ensuring that the drug candidates discovered are active in vivo. Several of the compounds discovered by the Peterson laboratory have become widely used research tools or preclinical drug candidates.Dr. Peterson received his PhD from Harvard University where he studied as a Howard Hughes Medical Institute predoctoral fellow in the laboratory of Stuart Schreiber.  He completed a postdoctoral fellowship with Mark Fishman at Massachusetts General Hospital. Dr. Peterson spent 14 years as a faculty member at Harvard University where he was the Charles Addison and Elizabeth Ann Sanders Chair in Basic Science at Harvard Medical School\, Scientific Director of the MGH Cardiovascular Research Center\, and Senior Associate Member of the Broad Institute.  In 2017 he moved to the University of Utah as L.S. Skaggs Presidential Endowed Professor and Dean of the College of Pharmacy. \n\n\n\nTitle of the talk: High-throughput biology at the organismal level\n\n\n\nThe impact of high-throughput technologies on biological research has been remarkable. For example\, high-throughput drug screens have revolutionized drug discovery\, and high-throughput CRISPR screens are revolutionizing gene discovery. Notably\, these techniques have focused almost entirely on simple\, in vitro or cell-based assays\, leaving untouched organismal processes such as embryonic development\, physiology\, and animal behavior. These organismal processes are best studied in vivo\, and consequently have not been amenable to high-throughput biology. The Peterson lab is focused on applying high-throughput technologies to such organismal processes and is developing methodologies that enable CRISPR screens and small molecule screens to be applied to organismal processes in zebrafish. Recently\, we have discovered small molecules and genes with novel activities on the cardiovascular\, nervous\, and endocrine systems. I will describe how the compounds and genes were discovered\, what they have taught us about biology\, and how they might find practical or clinical utility. \n\n\n\nHost: Marcel den Hoed marcel.den_hoed@igp.uu.se\, UU URL:https://www.scilifelab.se/event/the-svedberg-randall-peterson-prof/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221107T151500 DTEND;TZID=Europe/Stockholm:20221107T161500 DTSTAMP:20260511T032415 CREATED:20221025T140529Z LAST-MODIFIED:20221103T114505Z UID:10000721-1667834100-1667837700@www.scilifelab.se SUMMARY:[The Svedberg] - Studying microRNA functions at the single-cell level DESCRIPTION:MicroRNAs are gene regulatory molecules that play important roles in numerous biological processes including human health. The function of a given microRNA is defined by its selection of target transcripts\, yet current state-of-the-art experimental methods to identify microRNA targets are laborious and require millions of cells – hampering the entry of the microRNA field into the single-cell era. We have overcome these limitations by fusing the microRNA effector protein Argonaute2 to the RNA editing domain of ADAR2\, allowing for the first time the detection of microRNA targets transcriptome-wide in single cells. Our agoTRIBE method reports functional microRNA targets which are additionally supported by evolutionary sequence conservation. As a proof-of-principle\, we study microRNA interactions in single cells\, and find substantial differential targeting across the cell cycle. In addition to presenting this single-cell project\, I will talk about our recent efforts to sequence RNA fragments from ancient animal samples that are preserved in the Siberian permafrost. \n\n\n\nMarc Friedländer is an associate professor at Stockholm University\, Department of Molecular Biosciences. He graduated from his master’s thesis under the supervision of Anders Krogh in Copenhagen and his PhD in the group of Nikolaus Rajewsky in Berlin. He founded his own lab in Stockholm with funding from a SciLifeLab Fellowship and an ERC starting grant. His team is balanced between wet-lab and dry-lab biologists\, and they develop and apply experimental and computational methods to understand gene regulation – with particular emphasis on microRNAs. His lab has studied these molecules in the context of space exposure (a collaboration with NASA); in ancient animal samples preserved in permafrost; and in mammalian single cells. \n\n\n\nWebpage: www.friedlanderlab.org URL:https://www.scilifelab.se/event/the-svedberg-marc-friedlander-assoc-prof/ CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221017T151500 DTEND;TZID=Europe/Stockholm:20221017T161500 DTSTAMP:20260511T032415 CREATED:20221009T184510Z LAST-MODIFIED:20221009T185208Z UID:10000710-1666019700-1666023300@www.scilifelab.se SUMMARY:[The Svedberg] - Manfred Schartl DESCRIPTION:Developmental Biochemistry\, University of Würzburg\, Germany \n\n\n\nTime: 15:15Venue: C8:305\, BMC\, Uppsala \n\n\n\nHost: Leif Andersson\, Uppsala University \n\n\n\nTitle of the talk: Evolution of sex determination and sex chromosomes in fish \n\n\n\nBio: Prof. Manfred Schartl studied Biology and Chemistry at the University of Giessen\, Germany\, and graduated in Genetics. After postdoctoral research in Giessen and at the NIH in Bethesda he was team leader of a research group from 1985 to 1991 at the Gene Center of the Max Planck Institute for Biochemistry in Martinsried\, Germany. Until 2019 he was full professor and chairman of Physiological Chemistry at the Biocenter of the University of Würzburg. Currently\, he heads a research group as senior professor at the Biocenter and works as scholar in residence at the Xiphophorus Genetic Stock Center at Texas State University in San Marcos. He is member of the German Academy of Sciences\, Leopoldina\, and the European Academy of Sciences\, Academia Europea. He holds an honorary doctorate from the University of Bergen\, Norway.He uses the small aquarium fish biomedical models Xiphophorus and Medaka to understand molecular processes of organ development and their malfunction in disease with a focus on pigment cells and melanoma and another one on sex determination and gonad development. Key to his research is taking an evolutionary perspective to answer these questions on the basis of comparative genomics and molecular biology experimental studies. \n\n\n\nAbstract: Sex determination (SD) is unique biological process in showing an astonishing plasticity of mechanisms. Fish present the greatest variability of SD amongst vertebrates. In the case of genetic SD this is linked to a similarly high variability of sex chromosome differentiation. While in a handful of species with genetic SD the master SD genes have been identified\, their molecular function in directing the development of the bipotential gonad primordium towards testis or ovary is unclear in many cases or incompletely known in the others. To obtain a deeper understanding of this diversity we need a better knowledge of the molecular basis of SD mechanisms and the structure and genetic organization of sex chromosomes across a broad diversity of fish. To identify sex chromosomes and primary SD genes\, we use high throughput RAD-tag marker mapping\, transcriptomics\, Pool-Seq and whole genome sequencing to identify sex-specific chromosomal regions and candidate SD genes in sharks\, sturgeons and teleosts. This led to the identification of sex-specific markers\, allowing to delineate the extent of recombination suppression\, which turned out to be highly variable between species. We identified several species with clear cut XX/XY or ZZ/ZW monofactorial systems but also species with more complex sex-determination systems including species with a mix of genetic SD and environmental SD and species with potential polygenic systems. In species with available genomic resources\, sex-specific markers could be used to assign scaffolds to regions that are supposed to contain the primary SD gene. We identified candidate genes in several species and find that most of them belong to already known factors of the primary SD regulatory network including candidate genes that have not been found so far as being SD genes. We also find that many species harbor very poorly differentiated sex-chromosomes. The SD variety does not follow a phylogenetic pattern\, and turnovers of the genetic SD system from male to female heterogamety and vice versa are frequent in some groups\, making the evolutionary instability of SD a spectacular trait whose biological meaning is not yet understood. URL:https://www.scilifelab.se/event/the-svedberg-manfred-schartl/ CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20221013T151500 DTEND;TZID=Europe/Stockholm:20221013T163000 DTSTAMP:20260511T032415 CREATED:20221005T112555Z LAST-MODIFIED:20221005T113202Z UID:10000707-1665674100-1665678600@www.scilifelab.se SUMMARY:[The Svedberg seminar] Prof. Jay Hinton DESCRIPTION:University of Liverpool\, UK \n\n\n\nTime: 15:15Venue: C8:305\, BMC\, Uppsala \n\n\n\nHost: Siv Andersson\, Uppsala University \n\n\n\nProf. Jay Hinton is Professor of Microbial Pathogenesis at the University of Liverpool. Prof. Prof. Hinton has developed RNA-seq-based approaches for studying gene expression of in vitro-grown and intra-macrophage bacteria. He is currently using functional genomics methods to understand how new Salmonella pathovariants are causing endemic bloodstream infections across sub-Saharan Africa. This disease has killed around 500\,000 people over the last decade. \n\n\n\nTitle of the talk: How has Salmonella become so dangerous in Africa?\n\n\n\nWith 3.4 million infections each year\, invasive non-Typhoidal Salmonella (iNTS) is a major cause of illness worldwide. In Sub-Saharan Africa\, bloodstream infections involving iNTS Salmonella enterica serovar Typhimurium are causing ~49\,000 deaths annually. Co-infection with HIV or malaria in adults\, and a young age (<5 years) are known risk factors. The main causative agent of iNTS is a pathovariant of Salmonella Typhimurium called ST313\, which is multi-drug resistant and closely-related to the ST19 type of Salmonella responsible for gastroenteritis globally. \n\n\n\nUsing a combination of comparative genomics and comparative transcriptomics\,we discovered phenotypic differences that distinguish African from global Salmonella pathovariants (Canals et al.\, 2019; Honeycutt et al.\, 2020). \n\n\n\nOur analysis led us to identify a single core genome SNP responsible for the up-regulation of a single promoter in strain D23580 that controlled the expression of a Salmonella virulence factor (Hammarlöf et al.\, 2018)\, and offers part of the explanation of the pan-African epidemic of bloodstream infection.All of the Salmonella transcriptomic data we have generated are now available online in a user-friendly website that allows intra-strain and inter-strain comparisons of gene expression between African and global pathovariants ofS. Typhimurium: https://tinyurl.com/SalComD23580 \n\n\n\nMost recently\, we used the combined power of genomics and epidemiology and thousands of historical and contemporary Salmonella isolates to understand the precise evolutionary trajectory of the S. Typhimurium ST313 pathogen in Africa. We identified a series of novel genome degradation events that impacted upon the function of Salmonella genes required for colonisation of the mammalian gut\, providing evidence of niche adaptation and the continuing evolution of ST313 (Pulford et al.\, 2021). \n\n\n\nI will summarise the evolutionary pathway of invasive S. Typhimurium across Africa\, and explain the value of an integrated functional genomic analysis for understanding how bacterial pathogens cause disease. \n\n\n\nReferencesCanals et al. (2019) Adding function to genome of African Salmonella Typhimurium ST313. PLoS Biology 17(1): e3000059. DOI: 10.1371/journal.pbio.3000059 \n\n\n\nHammarlöf et al. (2018) Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella. PNAS 115: E2614 – E2623. \n\n\n\nDOI: 10.1073/pnas.1714718115 \n\n\n\nHoneycutt et al. Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa. PLoS Pathog. 2020 16:e1008763. DOI: 10.1371/journal.ppat.1008763 \n\n\n\nPulford et al. (2021) Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa. Nature Microbiology 6: 327–338. \n\n\n\nDOI:10.1038/s41564-020-00836-1 URL:https://www.scilifelab.se/event/the-svedberg-seminar-prof-jay-hinton/ CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20220523T151500 DTEND;TZID=Europe/Stockholm:20220523T161500 DTSTAMP:20260511T032415 CREATED:20220422T114620Z LAST-MODIFIED:20220523T063854Z UID:10000592-1653318900-1653322500@www.scilifelab.se SUMMARY:The Svedberg seminar: Tanja Slotte DESCRIPTION:Tanja Slotte\, Assoc. Prof.Stockholm University\, Sweden \n\n\n\nRegister and get the Link\n\n\n\nAssoc. Prof. Tanja Slotte is a population geneticist who is interested in the genetic causes and genomic consequences of plant mating system shifts and the evolution of mating system supergenes. She received her PhD from Uppsala University in 2007\, followed by a postdoc at University of Toronto. She started her own group at Uppsala University in 2010 and moved to Stockholm University to take up a SciLifeLab Fellow position in 2014. She is currently Associate Professor in Ecological Genomics at Stockholm University. \n\n\n\nTitle of the seminar: Sequencing the supergene that governs Darwin’s different forms of flower\n\n\n\nSupergenes are responsible for a wide variety of balanced polymorphisms in nature\, yet our understanding of their origins and evolution remains incomplete. The reciprocal placement of stigmas and anthers in pin and thrum floral morphs of distylous species constitutes an iconic example of a balanced polymorphism governed by a supergene. Recent studies have shown that the Primula distyly S-locus supergene is hemizygous due to structural variation at the supergene. If this genetic architecture is common to other distyly supergenes\, it could have major implications for the evolution and loss of distyly. To shed further light on this question we have characterized the genetic architecture and evolution of the distyly supergene in Linum\, one of the plant systems where Dawin first described distyly. We have generated multiple high-quality genome assemblies of Linum species as a genomic framework for evolutionary studies. Here\, we leverage this framework to identify the distyly S-locus supergene and study its evolution and expression. Our results show that hemizygosity and thrum-specific expression are major features of the Linum distyly supergene\, and suggest that the supergene has arisen in a stepwise manner. Our findings demonstrate remarkable convergence in the genetic architecture\, origin and evolution of the distyly supergene among systems with independently derived distyly\, and shed light on the evolution of the classic supergene that governs Darwin’s “different forms of flowers”. URL:https://www.scilifelab.se/event/the-svedberg-seminar-tanja-slotte/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/Picture1-The-Svedberg-edited.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20220516T171500 DTEND;TZID=Europe/Stockholm:20220516T181500 DTSTAMP:20260511T032415 CREATED:20220422T112304Z LAST-MODIFIED:20220505T130333Z UID:10000591-1652721300-1652724900@www.scilifelab.se SUMMARY:The Svedberg seminar: Simon Elsässer DESCRIPTION:Register and get the link here\n\n\n\n\n\nSimon Elsässer is Associate Professor at Karolinska Institutet\, Department of Medical Biochemistry and Biophysics. He has studied at University of Tübingen and Harvard University\, and received his Ph.D. from The Rockefeller University in 2012. He has performed postdoctoral research at MRC Laboratory of Molecular Biology and was recruited to Karolinska Institutet as a SciLifeLab Fellow in 2015. His research combines synthetic biology methods to probe and manipulate proteins in the living cell with quantitative ‘omics readouts\, focusing on stem cells\, gene expression regulation and epigenomics. \n\n\n\nTitle of the seminar: Exploring the dynamics of the pluripotent epigenome and lineage choice in development\n\n\n\n \n\n\n\nShort Abstract: \n\n\n\nThe first lineage choice made in human embryo development separates trophectoderm from the inner cell mass\, which proceeds to form the pluripotent epiblast and primitive endoderm. We discovered that Polycomb repressive complex 2 (PRC2) maintains naïve pluripotency and restricts an intrinsic capacity of pre-implantation pluripotent stem cells to give rise to extraembryonic lineages. Through quantitative ChIP-seq and single-cell transcriptomics\, we demonstrate that PRC2-mediated repression provides a highly adaptive mechanism to restrict lineage potential during early human development.Webpage: http://www.elsaesserlab.org URL:https://www.scilifelab.se/event/simon-elsasser/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/Picture1-The-Svedberg-edited.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20220509T151500 DTEND;TZID=Europe/Stockholm:20220509T160000 DTSTAMP:20260511T032415 CREATED:20220502T101150Z LAST-MODIFIED:20220502T101852Z UID:10000598-1652109300-1652112000@www.scilifelab.se SUMMARY:The Svedberg seminar: Daniel Fürth DESCRIPTION:Assistent Professor\, SciLifeLab Fellow at Uppsala University \n\n\n\nHybrid event: Trippelrummet\, Navet\, BMC and Online \n\n\n\n\n\n\n\n\n\nRegister here\n\n\n\nDr. Daniel Fürth completed his Ph.D. in neuroscience at Karolinska Institutet\, working on mesoscale connectomics using modified rabies virus tracing\, then postdoctoral work in RNA biology and method development at Cold Spring Harbor Laboratory\, Cancer Center\, New York. At Cold Spring Harbor he focused on enabling functional RNA genomics in situ at subcellular single-molecule resolution. Dr. Fürth’s expertise as a leader in both wet and dry lab neuroscience is internationally recognized with a Brain & Behavior Research Foundation NARSAD Young Investigator Award and computational funding from the Chan Zuckerberg Initiative. Dr. Fürth’s lab studies how information is stored\, processed and transmitted between cells. The focus is to find hitherto unknown mechanisms that can transfer symbolic information between cells. Identification of such transmission would enable us to read and write those messages.  \n\n\n\nTitle of the seminar: From in situ to in vivo sequencing\n\n\n\nUnbiased investigation of subcellular RNA localization and its control in vivo remains challenging. Current hybridization-based methods cannot differentiate small regulatory variants\, whilein situ sequencing is limited by short reads. We solved these problems using a bidirectional sequencing chemistry to efficiently image transcript-specific barcodes in situ\, which are then extracted and assembled into longer reads using NGS. Specific cis-regulatory elements usually found in mRNA 3′UTRs mediate RNA localization. Reverse transcription was primed towards the 3’UTR/polyA-tail junction in developing Drosophila and we discovered that in situ cDNA synthesis stalls just downstream of RNA-binding protein crosslink sites\, resulting in truncated cDNAs near RNA-binding protein motifs. We utilized these stop signatures to spatially map cis-regulatory motifs in specific alternative polyadenylation (APA) isoforms. A subset of genes displayed expression of two or more APA isoforms with distinct localization in situ\, to which we could identify their putative trans-acting partners. We validated our findings using both iCLIP-seq and targeted clampFISH probes. Our platform\, therefore\, provides a powerful way to discover novel RNA variants and protein interactions and their localization in situ. Lastly\, I’ll present recent developments of a fluorogenic and non-enzymatic sequencing chemistry capable of sequencing single molecules directly in live cells with subcellular precision. URL:https://www.scilifelab.se/event/the-svedberg-seminar-daniel-furth/ LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/Picture1-The-Svedberg-edited.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20220502T151500 DTEND;TZID=Europe/Stockholm:20220502T161500 DTSTAMP:20260511T032415 CREATED:20220422T104856Z LAST-MODIFIED:20220422T111337Z UID:10000590-1651504500-1651508100@www.scilifelab.se SUMMARY:The use of systems biology in treatment of liver diseases DESCRIPTION:Adil Mardinoglu\, Assoc. Prof.KTH SwendenKing s College London\, UK\n\n\n\n \n\n\n\nRegister here to get the zoom link\n\n\n\nAssoc. Prof. Adil Mardinoglu is an expert in the field of Systems Medicine\, Systems Biology\, Computational Biology and Bioinformatics. He lead a team of 25 researchers working in the area of computational biology\, experimental biology and drug development to develop new treatment strategies for Metabolic diseases\, Neurodegenerative diseases and certain type of cancers  \n\n\n\n Abstract: Biological networks can provide a scaffold for studying biological pathways operating in the liver in connection with disease development in a systematic manner. In my presentation\, I will present our recent work where biological networks have been employed to identify the reprogramming in liver physiology in response to NASH/NAFLD. I will further discuss how this mechanistic modelling approach can contribute to the discovery of biomarkers and identification of drug targets which may lead to design of targeted and effective personalized medicine. \n\n\n\nWebpage: https://sysmedicine.com/ URL:https://www.scilifelab.se/event/adil-mardinoglu/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20220411T151500 DTEND;TZID=Europe/Stockholm:20220411T161500 DTSTAMP:20260511T032415 CREATED:20220315T160745Z LAST-MODIFIED:20220404T080634Z UID:10000558-1649690100-1649693700@www.scilifelab.se SUMMARY:Decreased levels of oxygen radicals cause autoimmune disease. DESCRIPTION:Prof. Rikard Holmdahl \n\n\n\nKarolinska Institute\, Sweden \n\n\n\nRegister HERE\n\n\n\nRikard Holmdahl made his PhD (1985) and MD (1987) at Uppsala University. Professor in medical inflammation research Lund University 93-07. Professor at Karolinska Institute from 2008 \n\n\n\n\n\n\n\nVenue: Hybrid meeting – Trippelrummet\, Navet and zoom \n\n\n\n\n\n\n\n\n\n \n\n\n\nTitle of the seminar: Finding and understanding genes associated with common diseases; decreased levels of oxygen radicals cause autoimmune disease\n\n\n\nA long-standing challenge is to understand which genes that cause common complex diseases\, such as rheumatoid arthritis\, atherosclerosis or cancer\, and thereby understand the disease causes. However\, even though we know the human sequence and can genotype millions of individuals it is very difficult to conclusively identify the single nucleotide variants that cause the diseases. We have taken another approach through animal models. Both genetics and diseases show similarities with humans\, and we have shown that it is possible to not only identify the loci associated with disease but also exactly position the polymorphic nucleotides for common autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).  \n\n\n\nI will focus on the first gene that we cloned\, Ncf1\, which regulate immune tolerance through different levels of oxygen radicals\, or more precisely hydrogen peroxide. It is the major gene causing SLE and is important in Sjögren’s syndrome and RA and most likely most autoimmune disease. \n\n\n\nTo understand the role of Ncf1 is also complicated as peroxide seem to regulate many different pathways leading to autoimmune diseases. I will discuss how we think it regulates RA and SLE but also how it could explain our normal behaviour\, thus explaining why Ncf1 variants are common in both rat and human population. \n\n\n\nRead more about ikard Holmdahl´s research http://ki.se/en/mbb/research-division-of-medical-inflammation-research URL:https://www.scilifelab.se/event/decreased-levels-of-oxygen-radicals-cause-autoimmune-disease/ LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20220328T151500 DTEND;TZID=Europe/Stockholm:20220328T161500 DTSTAMP:20260511T032415 CREATED:20220307T155747Z LAST-MODIFIED:20220315T155833Z UID:10000546-1648480500-1648484100@www.scilifelab.se SUMMARY:Digital twins for predictive\, preventive and personalised medicine DESCRIPTION:Prof. Mikael Benson\n\n\n\nLinköping University\, Sweden \n\n\n\n\n\nRegister HERE\n\n\n\n\n\n\n\n\n\nMikael Benson is a professor of pediatrics\, whose team aims to construct digital twins of individual patients for predictive\, preventive and personalised medicine \n\n\n\nDigital twins for predictive\, preventive and personalised medicine\n\n\n\nDigital twins are high-resolution models of individual patients. Each twin is computationally treated with thousands of drugs to find optimal drug or drugs for the patient: The twins are constructed by combining omics data down to the single cell level with routine clinical data. \n\n\n\nHost: Prof. Olli Kallioniemi \n\n\n\nRead more about the swedish digital twin consortium URL:https://www.scilifelab.se/event/the-svedberg-seminar-prof-mikael-benson/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20220314T151500 DTEND;TZID=Europe/Stockholm:20220314T161500 DTSTAMP:20260511T032415 CREATED:20220307T092733Z LAST-MODIFIED:20220309T145506Z UID:10000545-1647270900-1647274500@www.scilifelab.se SUMMARY:The Svedberg seminar series: Prof. Claudia Langenberg DESCRIPTION:Berlin Institute of Health at Charité Universitätsmedizin\, Berlin\, Germany and MRC Epidemiology Unit\, University of Cambridge\, UK \n\n\n\nLink to zoom meeting\n\n\n\n\n\n\n\n\n\n\n\n\n\nFrom molecules to health records: utility of omics at population scale\n\n\n\nApplication of different omic technologies is now feasible at population scale. This talk will present examples of how the integration of different omics in large patient and population studies can help to predict disease risk\, understand mechanisms\, and reveal shared connections between different diseases. \n\n\n\nShort bio: Claudia Langenberg is Professor of Computational Medicine at the Berlin Institute of Health at Charité (BIH) and MRC Investigator and Programme Leader at the MRC Epidemiology Unit at the University of Cambridge. Her research is focused on the genetic basis of metabolic control\, and her team studies its effects on health through integration of molecular with clinical data in large-scale patient and population-based studies. \n\n\n\nOmniScience\n\n\n\nComputational Medicine at Berlin Institute of Health\n\n\n\n \n\n\n\nHost: Jochen Schwenk\, KTH/SciLifeLab URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-prof-claudia-langenberg/ LOCATION:Online event via Zoom CATEGORIES:Event ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20211122T151500 DTEND;TZID=Europe/Stockholm:20211122T163000 DTSTAMP:20260511T032415 CREATED:20211110T141705Z LAST-MODIFIED:20211122T105625Z UID:10000484-1637594100-1637598600@www.scilifelab.se SUMMARY:The Svedberg seminar series: Prof. Tuuli Lappalainen DESCRIPTION:Science for Life Laboratory\, Department of Gene Technology\, KTH Royal Institute of Technology\, Stockholm\, Sweden \n\n\n\nNew York Genome Center\, New York\, USA \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nTuuli Lappalainen is a Professor in Genomics at KTH Royal Institute of Technology\, an Associate Faculty Member at the New York Genome Center\, and the Director of the National Genomics Infrastructure of SciLifeLab. She is also an Adjunct Professor at the Department of Systems Biology at Columbia University. \n\n\n\nHer research focuses on functional genetic variation in human populations and its contribution to traits and diseases. She has pioneered the intergration of large-scale genome and transcriptome sequencing data to understand how genetic variation affects gene expression\, providing insight to cellular mechanisms underlying genetic risk for disease. \n\n\n\n\n\n\n\nFunctional variation in the human genome: lessons from the transcriptome\n\n\n\nDetailed characterization of molecular and cellular effects of genetic variants is essential for understanding biological processes that underlie genetic associations to disease. A particularly scalable approach has been linking genetic variants to effects in the transcriptome that is amenable for scalable measurements in human populations and in experimental settings\, including at the single cell level. Our multi-omic analysis in human cohorts in the TOPMed project has identified genetic and environmental effects on molecular variation together with their complex interplay with clinical phenotypes. Furthermore\, in this talk I will discuss how CRISPRi silencing of regulatory elements followed by single-cell analysis provides novel insights of mechanisms of genetic associations to complex traits. Altogether\, these diverse approaches for integration genome and transcriptome data uncover functional genetic architecture of human traits\, and enhances our understanding of both basic biology and precision medicine applications. \n\n\n\nHost: Jessica Nordlund\, Uppsala University URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-tuuli-lappalainen/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20211108T151500 DTEND;TZID=Europe/Stockholm:20211108T163000 DTSTAMP:20260511T032415 CREATED:20211005T080424Z LAST-MODIFIED:20211005T080541Z UID:10000460-1636384500-1636389000@www.scilifelab.se SUMMARY:The Svedberg seminar series: Ass. Prof. Maria Kasper DESCRIPTION:Karolinska Institutet\, Department of Cell and Molecular Biology\, Sweden \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\nMaria Kasper is Associate Professor at the Karolinska Institutet in Stockholm\, Department of Cell and Molecular Biology. She received her PhD at the University of Salzburg in genetics\, with the majors in human genetics and molecular tumor biology. She came to Sweden in 2007\, where she spent a fruitful postdoctoral time in Rune Toftgårds lab\, and in 2013 she started her own lab focusing on skin\, stem cell biology and single-cell RNA sequencing. In 2016\, her lab pioneered the use of single-cell transcriptomics in the organ skin and has overall contributed with important work in skin biology and regenerative medicine. Maria has received a number of national recognitions such as the Framtidens Forskningsledare from SSF\, Ragnar Söderberg Fellow in Medicine and the CIMED young investigator award\, as well as the prestigious international LEO Foundation Gold Award for outstanding skin research. Since 2020\, she also coordinates together with Fiona Watt the Human Cell Atlas bionetwork for the organ skin. \n\n\n\nDecoding the molecular anatomy of skin\n\n\n\nSkin architecture and its function are determined by a rich variety of epithelial\, mesenchymal and immune cells that together orchestrate skin homeostasis\, including cyclical hair growth and barrier function. Previously\, my lab generated a comprehensive molecular and spatial atlas of epithelial and stromal cells during hair growth and rest. These studies revealed underlying molecular programs during progenitor-cell commitment and lineage differentiation\, as well as spatiotemporal fibroblast heterogeneity and potential epithelial-stromal interactions. The importance of cell-type specific signaling during homeostasis\, and the unrecognized potential of cell-type restricted signaling-changes were exemplified by our recent discovery of how to induce new hair follicles in adult mouse skin by modulating a single signaling pathway. Building on the molecular knowledge and computational skills gained\, our ongoing work uncovers new insights in the molecular orchestration of embryonic hair follicle development\, as well as the coordination of adult skin stem cell differentiation by tissue resident immune cells.Host: Gabriella Lindgren\, SLU URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-ass-prof-maria-kasper/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20211018T151500 DTEND;TZID=Europe/Stockholm:20211018T161500 DTSTAMP:20260511T032415 CREATED:20210916T151516Z LAST-MODIFIED:20210927T100311Z UID:10000448-1634570100-1634573700@www.scilifelab.se SUMMARY:The Svedberg seminar series: Ass. Prof. Prashant Singh DESCRIPTION:SciLifeLab Fellow at Uppsala University \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\nPrashant Singh is a SciLifeLab fellow and Assistant Professor hosted by the Division of Scientific Computing\, Department of Information Technology\, Uppsala University. His research interests involve developing machine learning and optimization methods to enable fast\, data-efficient analysis and processing of scientific data\, particularly in the domain of life sciences. \n\n\n\nScalable Likelihood-Free Parameter Inference of Stochastic Biochemical Reaction Networks\n\n\n\nAbstract: Parameter inference of stochastic time series models\, such as gene regulatory networks in the likelihood-free setting is a challenging task\, particularly when the number of parameters to be inferred is large. Recently\, data-driven machine learning models (neural networks in particular) have delivered encouraging results towards addressing the scalability\, efficiency and parameter inference quality of the likelihood-free parameter inference pipeline. In particular\, this talk will present a detailed discussion on neural networks as trainable\, expressive and scalable summary statistics of high-dimensional time series for parameter inference tasks. \n\n\n\nReference: \n\n\n\nM. Akesson\, P. Singh\, F. Wrede and A. Hellander\, “Convolutional Neural Networks as Summary Statistics for Approximate Bayesian Computation\,” in IEEE/ACM Transactions on Computational Biology and Bioinformatics\, doi: 10.1109/TCBB.2021.3108695. \n\n\n\nHost: Prof. Elisabeth Larsson\, Uppsala University URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-assoc-prof-prashant-singh/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20211011T151500 DTEND;TZID=Europe/Stockholm:20211011T163000 DTSTAMP:20260511T032415 CREATED:20210927T110517Z LAST-MODIFIED:20211005T080643Z UID:10000455-1633965300-1633969800@www.scilifelab.se SUMMARY:The Svedberg seminar series: Prof. Paolo Parini DESCRIPTION:Theme Inflammation and Ageing\, Karolinska University Hospital\, \n\n\n\nDepartment of Laboratory Medicine and Department of Medicine \n\n\n\nKarolinska Institutet at Huddinge University Hospital\, \n\n\n\n\n\nLINK TO SEMINAR \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\n\n\nProf. Paolo Parini gained his MD degree in 1990 at the Universita’ di Bologna\, Italy. In 1994 he obtained his specialization in Gastroenterology and Hepatology (Universita’ di Bologna\, Italy). The same year Parini was registered as PhD-student at the Karolinska Institutet\, Sweden\, under the supervision of Prof Mats Rudling and Prof Bo Angelin. In 1999\, he obtained his PhD defending a thesis entitled “Hormonal regulation of hepatic cholesterol and lipoprotein metabolism: effects of estrogen and growth hormone” and since then his research activities are focused on the different aspect of lipoprotein metabolism in humans and in preclinical models. \n\n\n\nNetwork Medicine Approach to Atherosclerosis\n\n\n\nDuring the last several decades non-communicable diseases (NCDs) have dramatically increased deaths globally. One of the most prevalent NCD\, atherosclerotic cardiovascular disease (ASCVD) and cardiometabolic disease (CMD)\, are now major global health threats and socioeconomic burdens. Combined Hyperlipidemia (CH) is the most common form of hyperlipidemia and impacts longevity by promoting ASCVD\, CMD. Conventional ‘omics studies\, designed to find simple associations between genotype and phenotype in large datasets\, are inherently incapable of unraveling the complex pathobiology underlying diseases. Using network analysis\, we aim to describe the effects of the peripheral lipoprotein phenotypes of CH described in a multidimensional space by modules of functional interactions\, using patients from different existing cohorts to understand whether CH drives accelerated biological ageing\, estimated by analysis of the epigenome (DNA-methylation) in conjunction with specific ICD-10 diagnoses and treatments as a function of chronological age. We plan to integrate data of different nature [e.g.\, genetic\, epigenetic\, biochemistry\, national registries\, and electronic health record (EHR)\, and patient reported outcome measures (PROM) questionnaires]. As initial proof-of-concept\, we have created novel multi-source networks in which single-source analyses (i.e.\, liver transcriptomics and epigenomics) are integrated with biochemical parameters and lipoprotein functionality in combination with  Dr. Joseph Loscalzo´s human PPI Personal Protein I. Patients were from the Stockholm Study\, in non-obese\, normolipidemic\, gallstone patients (66% female) were randomized to a 4-week treatment with simvastatin 80 mg/day and ezetimibe 10 mg/day\, alone or in combination\, or to placebo. The first network mining has already indicated a constant and previously unknown interaction between a key gene in cholesterol metabolism and TMBIM6\, a transmembrane protein involved in autophagy and cancer information contained in the multi-source networks. Validation studies of this initial finding in going on in Soat2-only HepG2 cells\, a unique pre-clinical model which more closely resembles human lipoprotein metabolism created by us. \n\n\n\nHost: Olli Kallioniemi\, SciLifeLab Director URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-paolo-parini/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20211004T151500 DTEND;TZID=Europe/Stockholm:20211004T161500 DTSTAMP:20260511T032415 CREATED:20210916T094629Z LAST-MODIFIED:20210923T122426Z UID:10000447-1633360500-1633364100@www.scilifelab.se SUMMARY:The Svedberg seminar series: Ass. Prof. Daniel Espes DESCRIPTION:SciLifeLab Fellow at Uppsala University \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\nDaniel Espes received his completed his PhD at the Department of Medical Cell Biology\, Uppsala University\, in 2016 and became an Associate Professor (Docent) in Medical Cell Biology in 2019. In parallel with his research career he has worked actively as a clinical physician and became a specialist in internal medicine in 2019. In 2021 Espes joined as a SciLife Fellow and his translational group is focused on the development of clinically applicable techniques for assessing beta-cell mass alterations within the human pancreas during the development of diabetes. \n\n\n\nImagine Imaging Beta-Cell Mass\n\n\n\nType 1 diabetes is one of the most common chronic disease among children and adolescents. Due to the long-term complications associated with the disease the life-expectancy for those living with the disease is reduced by more than 10 years. Type 1 diabetes develops due to progressive loss of the insulin producing beta-cells following an immune attack. However\, the underlying trigger for the immune system is still unknown. At onset of hyperglycemia 60-70% of the beta-cell mass have already been lost\, based on data from autopsy studies. Currently there are no validated techniques for evaluating beta-cell mass in vivo in humans and hence our understanding of how beta-cell mass is altered in health and disease is limited to what we have learned from autopsy material. Our work is focused on establishing novel techniques for the quantification of beta-cell mass in order to increase our understanding of how diabetes develops as well as how beta-cell mass adapts in response to other conditions. In addition\, we are trying to better understand the immunological and metabolic interactions within the pancreas by combining imaging techniques with functional assessments. \n\n\n\nHost: Ass. Prof. Gustaf Christoffersson URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-assoc-prof-daniel-espes/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20210928T151500 DTEND;TZID=Europe/Stockholm:20210928T163000 DTSTAMP:20260511T032415 CREATED:20210923T094943Z LAST-MODIFIED:20210923T122525Z UID:10000453-1632842100-1632846600@www.scilifelab.se SUMMARY:The Svedberg seminar series: Prof. Ana Pombo DESCRIPTION:MDC Berlin Institute for Medical Systems Biology (BIMSB) \, Humboldt University\, Germany \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\nAna Pombo investigates mechanisms that regulate 3D genome folding and gene expression during mammalian  development and in disease. After her doctorate work at the University of Oxford (UK)\, Ana was a recipient of a Royal Society Dorothy Hodgkin Fellowship. She started her independent group in 2000\, at the MRC London Institute for Medical Sciences\, Imperial College London\, before moving to the Max Delbrueck Center for Molecular Medicine in Berlin\, in Germany. Ana received the Robert Feulgen Prize in 2007\, and was elected EMBO member in 2018. She is a Professor at the Humboldt University of Berlin and the Deputy Scientific Directed of the Berlin Institute for Medical Systems Biology at MDC. \n\n\n\nFunctional specialization of 3D genome structures in brain cell types\n\n\n\nDuring lineage commitment\, cells sustain cascades of gene activation and repression to generate specific cell types that execute specialized functions. To investigate the variability of the 3D conformation of the genome in different cell types and their relation with cell-type specific patterns of gene expression\, we applied Genome Architecture Mapping is specific brain cell types from the adult murine brain\, without disturbing their native tissue environment: dopaminergic neurons (DNs) from the midbrain\, pyramidal glutamatergic neurons (PGNs) from the hippocampus\, and oligodendrocyte lineage cells (OLGs) from the cortex. We find extensive reorganization of genome topology\, which the reorganization of topological domains\, chromatin compartments and specific long-range hubs of contacts between neuron-specific genes. We also discover events of extensive chromatin decondensation\, or ‘melting’\, at long neuronal genes when they are highly transcribed\, many of them associated with neurodevelopmental disorders or neurodegeneration. Our work shows that the 3D organization of the genome is highly specific of cell type and strongly related with gene expression programs.Read more about Ana Pombo`s research: https://www.mdc-berlin.de/pomboHost:  Eva Brinkman\, KI URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-ana-pombo/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20210920T151500 DTEND;TZID=Europe/Stockholm:20210920T163000 DTSTAMP:20260511T032415 CREATED:20210816T082333Z LAST-MODIFIED:20210916T154406Z UID:10000407-1632150900-1632155400@www.scilifelab.se SUMMARY:The Svedberg seminar series: Assoc. Prof. Daniel Globisch DESCRIPTION:SciLifeLab Fellow at Uppsala University / Dept. Chem – BMC \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\nAssociate Professor Daniel Globisch started his independent research group as a Science For Life Laboratory Fellow at Uppsala University. In December 2020\, Daniel Globisch received tenure and moved with his laboratory to the Department of Chemistry – BMC. He received his PhD in Organic Chemistry and Chemical Biology in 2011 at the Ludwig-Maximilians-University in Munich and joined The Scripps Research Institute\, La Jolla\, CA for his postdoctoral research in Chemical Biology and Metabolomics from 2011 to 2015. At Uppsala University\, his laboratory develops new Chemical Biology methodologies to extend the scope of metabolomics research to discover new biomarkers for pancreatic and colorectal cancer. The interdisciplinary nature of the research projects is focussed on elucidation of the metabolic interaction between the gut microbiota and their human host. \n\n\n\nExploring Gut Microbiota Metabolism – Unique Chemical Biology Tools for Metabolomics Analysis\n\n\n\nOne of the most exciting scientific developments in the past decade has been the understanding that the microbiome profoundly impacts human physiology. The complex consortium of trillions of microbes possesses a wide range of metabolic activity. This metabolic interspecies communication represents a tremendous opportunity for the discovery of unknown bioactive molecules as only limited information on this co-metabolism has been elucidated on a molecular level. Metabolomics holds a great potential for the discovery of unknown biomarkers and bioactive metabolites. Advanced Chemical Biology tools are limited compared to other ‘omics research fields. Especially\, the detailed analysis of microbial metabolism remains a major challenge and requires advanced techniques. We have developed unique Chemical Biology methodologies for enhanced analysis using liquid chromatography-coupled with tandem mass spectrometry. These tools overcome limitations in mass spectrometry-based metabolomics analysis. We apply these methods for the discovery of unknown metabolites in human samples collected from pancreatic cancer patients to evaluate their potential as biomarkers. URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-assoc-prof-daniel-globisch/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20210913T161500 DTEND;TZID=Europe/Stockholm:20210913T173000 DTSTAMP:20260511T032415 CREATED:20210830T090518Z LAST-MODIFIED:20210907T143831Z UID:10000419-1631549700-1631554200@www.scilifelab.se SUMMARY:The Svedberg seminar series: Dr. Aviv Regev DESCRIPTION:Genentech\, USA \n\n\n\nHost: Erik Sonnhammer \, Stockholm University \n\n\n\nZOOM LINK \n\n\n\n\n\n\n\n\n\nAviv Regev is a leader in deciphering molecular circuits that govern cells\, tissues and organs in health and their malfunction in disease. Her lab has pioneered foundational experimental and computational methods in single-cell genomics\, working toward greater understanding of the function of cells and tissues in health and disease\, including autoimmune disease\, inflammation and cancer \n\n\n\nCell atlases as roadmaps in health and disease\n\n\n\nCells are the basic unit of life\, and form a key intermediate between genotype and phenotype\, that is essential to explain how the gene variants that contribute to disease risk act. The recent advent of methods for high-throughput single-cell and spatial profiling has opened the way to create a human cells atlas: comprehensive reference maps of all human cells as a basis for both understanding human health and diagnosing\, monitoring\, and treating disease. From such maps we recovered rich aspects of biology\, including cell types and states\, differentiation and other temporal processes\, gene programs\, the physical location and interactions between cells\, the underlying regulatory circuits\, and even the possibility of predicting cell types and behaviors\, towards a “periodic table of our cells”. These\, in turn give us a new vocabulary for disease studies to determine the way in which cells do disease genes act\, which cells are disrupted in disease\, which programs change in them\, what mechanisms underlie their (dis)regulation\, how their cell-cell communications affected\, and what would be the impact of therapies. In this talk\, I will focus on how atlases help us to understand the relation between genotype to phenotype\, especially in the context of human genetics and disease\, from cells\, to programs\, to deciphering individual gene functions\, using single cell genomics as a conceptual and technical framework\, in complex disease\, cancer\, and COVID-19.Read more about Prof. Regev´s research HERE URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-regev-aviv/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20210823T151500 DTEND;TZID=Europe/Stockholm:20210823T163000 DTSTAMP:20260511T032415 CREATED:20210816T071003Z LAST-MODIFIED:20210816T093408Z UID:10000406-1629731700-1629736200@www.scilifelab.se SUMMARY:SciLifeLab The Svedberg seminar: Prof. Athula Attygalle DESCRIPTION: Stevens Institute of Technology\, USA \n\n\n\n\n\n\n\n\n\nLINK TO SEMINAR \n\n\n\n Prof. Athula Attygalle obtained a PhD in Chemistry from Keele University in 1983. After his doctorate\, Attygalle was awarded a Fellowship by the Humboldt Foundation to conduct research at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) under late Prof\, Hans Jürgen Bestmann\, a pioneer in the field of insect pheromone synthesis. Four years at FAU\, provided the impetus for Attygalle to become an expert in high-resolution mass spectrometry and micro-chemical techniques for structure elucidation of natural compounds at nanogram level. At FAU\, Attygalle championed in the area of lepidopteran sex pheromone identification. Attygalle was a visiting professor at University of Houston\, Texas and he has served as the Director of Mass Spectrometry facility at Cornell University. He has completed work there in GC-MS regarding insect substances and their identifications.  Currently Attygalle is attached to the Stevens Institute of Technology as a Research Professor in the Department of Chemistry and head of the mass spectrometry laboratory. Attygalle was the recipient of the 2014 ‘Inventor of the Year’ award presented by the New Jersey Inventors Hall of Fame for his patented work in Mass Spectrometric Analysis utilizing Helium Plasma and charge exchange ionization techniques. Attygalle co-authored the 1999 article “Single-Site Catalysts for Ring-Opening Polymerization:  Synthesis of Heterotactic Poly(lactic acid) from rac-Lactide” in the Journal of the American Chemical Society\, which has been widely cited. \n\n\n\nMultiple Personalities of Gaseous Ions \n\n\n\nFor mass spectrometry\, neutral molecules are converted to gaseous ions.   A mass spectrum is recorded by determining the mass-to-charge ratios and intensities of fragment ions generated by activating a specific ion. Many textbooks provide rules to identify molecules by interpreting their mass spectra.  All recommended interpretations start by presuming a specific structure for the initial ion.  However\, recent advances in ion-mobility methods demonstrate that an ensemble of ions with different structures are produced upon ionization. For example\, the most widely used electrospray ionization technique often generates a mixture of tautomeric forms of a precursor molecule.  Because fragmentation spectra of individual tautomers are often different from each other\, the spectra recorded without separating the isomeric mixtures are composites.  Although large collections of spectra are available as libraries\, the time has come to for us query of the quality of these compilations.                    \n\n\n\nHost: Kumari Ubhayasekera URL:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminar-prof-athula-attygalle/ LOCATION:Online event via Zoom CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20210524T151500 DTEND;TZID=Europe/Stockholm:20210524T163000 DTSTAMP:20260511T032415 CREATED:20210521T083002Z LAST-MODIFIED:20210521T094043Z UID:10000390-1621869300-1621873800@www.scilifelab.se SUMMARY:SciLifeLab The Svedberg seminar: Ehab Abouheif DESCRIPTION:Prof. Ehab Abouheif\n\n\n\nDepartment of Biology\, McGill University\, Canada \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\nAbouheif received a PhD in Biology from Duke University in 2002\, and from 2002 to 2004\, he completed his postdoctoral studies at the University of Chicago and at the University of California\, Berkeley. In 2004 Abouheif was appointed Assistant Professorship at McGill University as Canada Research Chair (tier 2) in Evolutionary Developmental Biology. Currently\, he is a James McGill Professor in the Department of Biology at McGill University. He is a pioneer of eco-evo-devo\, a field that integrates the concepts and technical tools of ecology\, evolutionary\, and developmental biology. Abouheif focuses on ant societies to understand the origins and evolution of complex biological systems. He served as founding President of the Pan-American Society for Evolutionary Developmental Biology and is currently Editor-in-Chief of JEZ-B: Molecular and Developmental Evolution\, one of the main journals in his field. \n\n\n\nDarwin’s invisible ink: The storage and release of ancestral genetic potential in complex biological systems\n\n\n\nAncestral and dormant genetic potentials exist in all animals\, as reflected by the sporadic appearance of ancestral traits in individuals that normally should not have them\, such as teeth in a chicken or hindlimbs in a whale. Such individuals are traditionally thought to be “freaks” that contribute little to the evolutionary process. Abouheif’s lab\, using supersoldier ants as their model\, has changed this traditional view by demonstrating that evolution can harness dormant genetic potentials after they have been released by certain environmental triggers. His lab also demonstrated that rudimentary organs\, like the human appendix\, are not functionless. Rather\, they can play key regulatory functions during development and store this ancestral genetic  potential over millions of years. These discoveries open up future possibilities for harnessing dormant genetic potentials to advance medicine\, biodiversity conservation\, and animal/plant breeding. \n\n\n\nHost: Arild HusbyRead more about Ehab Abouheif´s research URL:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminar-ehab-abouheif/ CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se LOCATION: END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20210524T151500 DTEND;TZID=Europe/Stockholm:20210524T161500 DTSTAMP:20260511T032415 CREATED:20210518T081818Z LAST-MODIFIED:20210524T113122Z UID:10000386-1621869300-1621872900@www.scilifelab.se SUMMARY:SciLifeLab The Svedberg seminar: Prof. Ehab Abouheif DESCRIPTION:Ehab Abouheif\n\n\n\nDepartment of Biology\, McGill University\, Canada \n\n\n\nLINK TO SEMINAR \n\n\n\n Abouheif received a PhD in Biology from Duke University in 2002\, and from 2002 to 2004\, he completed his postdoctoral studies at the University of Chicago and at the University of California\, Berkeley. In 2004 Abouheif was appointed Assistant Professorship at McGill University as Canada Research Chair (tier 2) in Evolutionary Developmental Biology. Currently\, he is a James McGill Professor in the Department of Biology at McGill University. He is a pioneer of eco-evo-devo\, a field that integrates the concepts and technical tools of ecology\, evolutionary\, and developmental biology. Abouheif focuses on ant societies to understand the origins and evolution of complex biological systems. He served as founding President of the Pan-American Society for Evolutionary Developmental Biology and is currently Editor-in-Chief of JEZ-B: Molecular and Developmental Evolution\, one of the main journals in his field. \n\n\n\nDarwin’s invisible ink: The storage and release of ancestral genetic potential in complex biological systems\n\n\n\nAncestral and dormant genetic potentials exist in all animals\, as reflected by the sporadic appearance of ancestral traits in individuals that normally should not have them\, such as teeth in a chicken or hindlimbs in a whale. Such individuals are traditionally thought to be “freaks” that contribute little to the evolutionary process. Abouheif’s lab\, using supersoldier ants as their model\, has changed this traditional view by demonstrating that evolution can harness dormant genetic potentials after they have been released by certain environmental triggers. His lab also demonstrated that rudimentary organs\, like the human appendix\, are not functionless. Rather\, they can play key regulatory functions during development and store this ancestral genetic  potential over millions of years. These discoveries open up future possibilities for harnessing dormant genetic potentials to advance medicine\, biodiversity conservation\, and animal/plant breeding. \n\n\n\nHost: Arild Husby \n\n\n\nRead more about Ehab Abouheif´s research URL:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminars-prof-ehab-abouheif/ CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se LOCATION:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminars-prof-ehab-abouheif/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20210518T151500 DTEND;TZID=Europe/Stockholm:20210518T161500 DTSTAMP:20260511T032415 CREATED:20210428T094603Z LAST-MODIFIED:20210512T085641Z UID:10000369-1621350900-1621354500@www.scilifelab.se SUMMARY:Statistical and machine learning techniques in microbiome research DESCRIPTION:Leo Lahti\n\n\n\nDepartment of Computing\, University of Turku\, Turku\, Finland \n\n\n\nLINK TO SEMINAR \n\n\n\nLeo Lahti is associate professor in data science in University of Turku\, Finland. After completing his PhD in Aalto University\, Finland\, in 2010 he carried out several years of postdoctoral research in The Netherlands and Belgium on population studies of the human microbiome. Lahti has organized various international training events in microbiome bioinformatics\, and he is the Finnish coordinator of the COST action on statistical and machine learning methods in microbiome studies. \n\n\n\nStatistical and machine learning techniques in microbiome research\n\n\n\nThe diverse microbial communities living in human body have a profound influence on our well-being. Human microbiome research has expanded rapidly following the recent advances in high-throughput DNA sequencing and other omics’ technologies. Consequently\, the demand for targeted computational methods has increased significantly in the recent years. We have a limited understanding of the overall mechanisms that control the observed variation and activity of these microbial ecosystems. Our observations have contributed to the systematic characterization of the individual dynamics and population variation of the human microbiome. I will discuss contemporary topics in statistical analysis and machine learning related to microbiome research\, with a specific emphasis on probabilistic latent variable models in understanding the individual and dynamic variation across the landscape of microbiome composition. \n\n\n\nHost: Anders Andersson \n\n\n\nRead more about Leo Lahti´s research URL:https://www.scilifelab.se/event/statistical-and-machine-learning-techniques-in-microbiome-research/ CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se LOCATION:https://www.scilifelab.se/event/statistical-and-machine-learning-techniques-in-microbiome-research/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Stockholm:20210510T131500 DTEND;TZID=Europe/Stockholm:20210510T140000 DTSTAMP:20260511T032415 CREATED:20210428T092922Z LAST-MODIFIED:20210507T075745Z UID:10000367-1620652500-1620655200@www.scilifelab.se SUMMARY:A more sustainable chemistry with elemental sulfur DESCRIPTION:Thanh Binh Nguyen\n\n\n\nUniversité Paris-Saclay\, France\n\n\n\nLINK TO THE SEMINAR\n\n\n\nAbstract\n\n\n\nFacing a more and more rapid depletion of natural resources\, one of the most challenging problems to be solved of modern organic chemistry is to develop reactions enabling access to target molecules from simple and readily available starting materials with higher efficiency in number of atoms while reducing the number of steps\, unnecessary redox changes and waste. With this idea in mind\, we have been concentrating on the use of elemental sulfur – an abundant waste of oil and gas industry with annual product up to 70 MT –  as a polyvalent synthetic tool. This lecture will focus on organic redox reactions developed in our laboratory involving this element as a new synthetic strategy that satisfies most of the requirements of a more sustainable chemistry. \n\n\n\nBiography\n\n\n\nThanh Binh Nguyen received his BS degree (2004) from the University of Natural Sciences in Hochiminh city\, Vietnam and subsequently his MS (2005) and PhD degrees (2008) from the the Université du Maine – Le Mans -France. After a two-year postdoctoral stay at the Institut de Chimie des Substances Naturelles – Gif-sur-Yvette – France\, he obtained a permanent research associate position (Chargé de Recherche) of the Centre National de la Recherche Scientifique (CNRS) in 2011\, working in the same institute. His main research interest is the development of new synthetic methods for carbon-nitrogen bond formation with a strong emphasis on using elemental sulfur\, molecular iodine and iron–sulfur catalysts. \n\n\n\nHost\n\n\n\nDuc Duy Vo\, Uppsala University URL:https://www.scilifelab.se/event/a-more-sustainable-chemistry-with-elemental-sulfur/ CATEGORIES:Event ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se LOCATION:https://uu-se.zoom.us/j/65768822626 END:VEVENT END:VCALENDAR