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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220502T151500
DTEND;TZID=Europe/Stockholm:20220502T161500
DTSTAMP:20260511T040739
CREATED:20220422T104856Z
LAST-MODIFIED:20220422T111337Z
UID:10000590-1651504500-1651508100@www.scilifelab.se
SUMMARY:The use of systems biology in treatment of liver diseases
DESCRIPTION:Adil Mardinoglu\, Assoc. Prof.KTH SwendenKing s College London\, UK\n\n\n\n \n\n\n\nRegister here to get the zoom link\n\n\n\nAssoc. Prof. Adil Mardinoglu is an expert in the field of Systems Medicine\, Systems Biology\, Computational Biology and Bioinformatics. He lead a team of 25 researchers working in the area of computational biology\, experimental biology and drug development to develop new treatment strategies for Metabolic diseases\, Neurodegenerative diseases and certain type of cancers  \n\n\n\n Abstract: Biological networks can provide a scaffold for studying biological pathways operating in the liver in connection with disease development in a systematic manner. In my presentation\, I will present our recent work where biological networks have been employed to identify the reprogramming in liver physiology in response to NASH/NAFLD. I will further discuss how this mechanistic modelling approach can contribute to the discovery of biomarkers and identification of drug targets which may lead to design of targeted and effective personalized medicine. \n\n\n\nWebpage: https://sysmedicine.com/
URL:https://www.scilifelab.se/event/adil-mardinoglu/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220411T151500
DTEND;TZID=Europe/Stockholm:20220411T161500
DTSTAMP:20260511T040739
CREATED:20220315T160745Z
LAST-MODIFIED:20220404T080634Z
UID:10000558-1649690100-1649693700@www.scilifelab.se
SUMMARY:Decreased levels of oxygen radicals cause autoimmune disease.
DESCRIPTION:Prof. Rikard Holmdahl \n\n\n\nKarolinska Institute\, Sweden \n\n\n\nRegister HERE\n\n\n\nRikard Holmdahl made his PhD (1985) and MD (1987) at Uppsala University. Professor in medical inflammation research Lund University 93-07. Professor at Karolinska Institute from 2008 \n\n\n\n\n\n\n\nVenue: Hybrid meeting – Trippelrummet\, Navet and zoom \n\n\n\n\n\n\n\n\n\n \n\n\n\nTitle of the seminar: Finding and understanding genes associated with common diseases; decreased levels of oxygen radicals cause autoimmune disease\n\n\n\nA long-standing challenge is to understand which genes that cause common complex diseases\, such as rheumatoid arthritis\, atherosclerosis or cancer\, and thereby understand the disease causes. However\, even though we know the human sequence and can genotype millions of individuals it is very difficult to conclusively identify the single nucleotide variants that cause the diseases. We have taken another approach through animal models. Both genetics and diseases show similarities with humans\, and we have shown that it is possible to not only identify the loci associated with disease but also exactly position the polymorphic nucleotides for common autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).  \n\n\n\nI will focus on the first gene that we cloned\, Ncf1\, which regulate immune tolerance through different levels of oxygen radicals\, or more precisely hydrogen peroxide. It is the major gene causing SLE and is important in Sjögren’s syndrome and RA and most likely most autoimmune disease. \n\n\n\nTo understand the role of Ncf1 is also complicated as peroxide seem to regulate many different pathways leading to autoimmune diseases. I will discuss how we think it regulates RA and SLE but also how it could explain our normal behaviour\, thus explaining why Ncf1 variants are common in both rat and human population. \n\n\n\nRead more about ikard Holmdahl´s research http://ki.se/en/mbb/research-division-of-medical-inflammation-research
URL:https://www.scilifelab.se/event/decreased-levels-of-oxygen-radicals-cause-autoimmune-disease/
LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220328T151500
DTEND;TZID=Europe/Stockholm:20220328T161500
DTSTAMP:20260511T040739
CREATED:20220307T155747Z
LAST-MODIFIED:20220315T155833Z
UID:10000546-1648480500-1648484100@www.scilifelab.se
SUMMARY:Digital twins for predictive\, preventive and personalised medicine
DESCRIPTION:Prof. Mikael Benson\n\n\n\nLinköping University\, Sweden \n\n\n\n\n\nRegister HERE\n\n\n\n\n\n\n\n\n\nMikael Benson is a professor of pediatrics\, whose team aims to construct digital twins of individual patients for predictive\, preventive and personalised medicine \n\n\n\nDigital twins for predictive\, preventive and personalised medicine\n\n\n\nDigital twins are high-resolution models of individual patients. Each twin is computationally treated with thousands of drugs to find optimal drug or drugs for the patient: The twins are constructed by combining omics data down to the single cell level with routine clinical data. \n\n\n\nHost: Prof. Olli Kallioniemi \n\n\n\nRead more about the swedish digital twin consortium
URL:https://www.scilifelab.se/event/the-svedberg-seminar-prof-mikael-benson/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220314T151500
DTEND;TZID=Europe/Stockholm:20220314T161500
DTSTAMP:20260511T040739
CREATED:20220307T092733Z
LAST-MODIFIED:20220309T145506Z
UID:10000545-1647270900-1647274500@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Prof. Claudia Langenberg
DESCRIPTION:Berlin Institute of Health at Charité Universitätsmedizin\, Berlin\, Germany and MRC Epidemiology Unit\, University of Cambridge\, UK \n\n\n\nLink to zoom meeting\n\n\n\n\n\n\n\n\n\n\n\n\n\nFrom molecules to health records: utility of omics at population scale\n\n\n\nApplication of different omic technologies is now feasible at population scale. This talk will present examples of how the integration of different omics in large patient and population studies can help to predict disease risk\, understand mechanisms\, and reveal shared connections between different diseases. \n\n\n\nShort bio: Claudia Langenberg is Professor of Computational Medicine at the Berlin Institute of Health at Charité (BIH) and MRC Investigator and Programme Leader at the MRC Epidemiology Unit at the University of Cambridge. Her research is focused on the genetic basis of metabolic control\, and her team studies its effects on health through integration of molecular with clinical data in large-scale patient and population-based studies. \n\n\n\nOmniScience\n\n\n\nComputational Medicine at Berlin Institute of Health\n\n\n\n \n\n\n\nHost: Jochen Schwenk\, KTH/SciLifeLab
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-prof-claudia-langenberg/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20211122T151500
DTEND;TZID=Europe/Stockholm:20211122T163000
DTSTAMP:20260511T040739
CREATED:20211110T141705Z
LAST-MODIFIED:20211122T105625Z
UID:10000484-1637594100-1637598600@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Prof. Tuuli Lappalainen
DESCRIPTION:Science for Life Laboratory\, Department of Gene Technology\, KTH Royal Institute of Technology\, Stockholm\, Sweden \n\n\n\nNew York Genome Center\, New York\, USA \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nTuuli Lappalainen is a Professor in Genomics at KTH Royal Institute of Technology\, an Associate Faculty Member at the New York Genome Center\, and the Director of the National Genomics Infrastructure of SciLifeLab. She is also an Adjunct Professor at the Department of Systems Biology at Columbia University. \n\n\n\nHer research focuses on functional genetic variation in human populations and its contribution to traits and diseases. She has pioneered the intergration of large-scale genome and transcriptome sequencing data to understand how genetic variation affects gene expression\, providing insight to cellular mechanisms underlying genetic risk for disease. \n\n\n\n\n\n\n\nFunctional variation in the human genome: lessons from the transcriptome\n\n\n\nDetailed characterization of molecular and cellular effects of genetic variants is essential for understanding biological processes that underlie genetic associations to disease. A particularly scalable approach has been linking genetic variants to effects in the transcriptome that is amenable for scalable measurements in human populations and in experimental settings\, including at the single cell level. Our multi-omic analysis in human cohorts in the TOPMed project has identified genetic and environmental effects on molecular variation together with their complex interplay with clinical phenotypes. Furthermore\, in this talk I will discuss how CRISPRi silencing of regulatory elements followed by single-cell analysis provides novel insights of mechanisms of genetic associations to complex traits. Altogether\, these diverse approaches for integration genome and transcriptome data uncover functional genetic architecture of human traits\, and enhances our understanding of both basic biology and precision medicine applications. \n\n\n\nHost: Jessica Nordlund\, Uppsala University
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-tuuli-lappalainen/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20211108T151500
DTEND;TZID=Europe/Stockholm:20211108T163000
DTSTAMP:20260511T040739
CREATED:20211005T080424Z
LAST-MODIFIED:20211005T080541Z
UID:10000460-1636384500-1636389000@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Ass. Prof. Maria Kasper
DESCRIPTION:Karolinska Institutet\, Department of Cell and Molecular Biology\, Sweden \n\n\n\nLINK TO SEMINAR   \n\n\n\n\n\n\n\n\n\nMaria Kasper is Associate Professor at the Karolinska Institutet in Stockholm\, Department of Cell and Molecular Biology. She received her PhD at the University of Salzburg in genetics\, with the majors in human genetics and molecular tumor biology. She came to Sweden in 2007\, where she spent a fruitful postdoctoral time in Rune Toftgårds lab\, and in 2013 she started her own lab focusing on skin\, stem cell biology and single-cell RNA sequencing. In 2016\, her lab pioneered the use of single-cell transcriptomics in the organ skin and has overall contributed with important work in skin biology and regenerative medicine. Maria has received a number of national recognitions such as the Framtidens Forskningsledare from SSF\, Ragnar Söderberg Fellow in Medicine and the CIMED young investigator award\, as well as the prestigious international LEO Foundation Gold Award for outstanding skin research. Since 2020\, she also coordinates together with Fiona Watt the Human Cell Atlas bionetwork for the organ skin. \n\n\n\nDecoding the molecular anatomy of skin\n\n\n\nSkin architecture and its function are determined by a rich variety of epithelial\, mesenchymal and immune cells that together orchestrate skin homeostasis\, including cyclical hair growth and barrier function. Previously\, my lab generated a comprehensive molecular and spatial atlas of epithelial and stromal cells during hair growth and rest. These studies revealed underlying molecular programs during progenitor-cell commitment and lineage differentiation\, as well as spatiotemporal fibroblast heterogeneity and potential epithelial-stromal interactions. The importance of cell-type specific signaling during homeostasis\, and the unrecognized potential of cell-type restricted signaling-changes were exemplified by our recent discovery of how to induce new hair follicles in adult mouse skin by modulating a single signaling pathway. Building on the molecular knowledge and computational skills gained\, our ongoing work uncovers new insights in the molecular orchestration of embryonic hair follicle development\, as well as the coordination of adult skin stem cell differentiation by tissue resident immune cells.Host: Gabriella Lindgren\, SLU
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-ass-prof-maria-kasper/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20211018T151500
DTEND;TZID=Europe/Stockholm:20211018T161500
DTSTAMP:20260511T040739
CREATED:20210916T151516Z
LAST-MODIFIED:20210927T100311Z
UID:10000448-1634570100-1634573700@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Ass. Prof. Prashant Singh
DESCRIPTION:SciLifeLab Fellow at Uppsala University \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\nPrashant Singh is a SciLifeLab fellow and Assistant Professor hosted by the Division of Scientific Computing\, Department of Information Technology\, Uppsala University. His research interests involve developing machine learning and optimization methods to enable fast\, data-efficient analysis and processing of scientific data\, particularly in the domain of life sciences. \n\n\n\nScalable Likelihood-Free Parameter Inference of Stochastic Biochemical Reaction Networks\n\n\n\nAbstract: Parameter inference of stochastic time series models\, such as gene regulatory networks in the likelihood-free setting is a challenging task\, particularly when the number of parameters to be inferred is large. Recently\, data-driven machine learning models (neural networks in particular) have delivered encouraging results towards addressing the scalability\, efficiency and parameter inference quality of the likelihood-free parameter inference pipeline. In particular\, this talk will present a detailed discussion on neural networks as trainable\, expressive and scalable summary statistics of high-dimensional time series for parameter inference tasks. \n\n\n\nReference: \n\n\n\nM. Akesson\, P. Singh\, F. Wrede and A. Hellander\, “Convolutional Neural Networks as Summary Statistics for Approximate Bayesian Computation\,” in IEEE/ACM Transactions on Computational Biology and Bioinformatics\, doi: 10.1109/TCBB.2021.3108695. \n\n\n\nHost: Prof. Elisabeth Larsson\, Uppsala University
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-assoc-prof-prashant-singh/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20211011T151500
DTEND;TZID=Europe/Stockholm:20211011T163000
DTSTAMP:20260511T040739
CREATED:20210927T110517Z
LAST-MODIFIED:20211005T080643Z
UID:10000455-1633965300-1633969800@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Prof.  Paolo Parini
DESCRIPTION:Theme Inflammation and Ageing\, Karolinska University Hospital\, \n\n\n\nDepartment of Laboratory Medicine and Department of Medicine \n\n\n\nKarolinska Institutet at Huddinge University Hospital\, \n\n\n\n\n\nLINK TO SEMINAR \n\n\n\n \n\n\n\n \n\n\n\n\n\n\n\n\n\nProf. Paolo Parini gained his MD degree in 1990 at the Universita’ di Bologna\, Italy. In 1994 he obtained his specialization in Gastroenterology and Hepatology (Universita’ di Bologna\, Italy). The same year Parini was registered as PhD-student at the Karolinska Institutet\, Sweden\, under the supervision of Prof Mats Rudling and Prof Bo Angelin. In 1999\, he obtained his PhD defending a thesis entitled “Hormonal regulation of hepatic cholesterol and lipoprotein metabolism: effects of estrogen and growth hormone” and since then his research activities are focused on the different aspect of lipoprotein metabolism in humans and in preclinical models. \n\n\n\nNetwork Medicine Approach to Atherosclerosis\n\n\n\nDuring the last several decades non-communicable diseases (NCDs) have dramatically increased deaths globally. One of the most prevalent NCD\, atherosclerotic cardiovascular disease (ASCVD) and cardiometabolic disease (CMD)\, are now major global health threats and socioeconomic burdens. Combined Hyperlipidemia (CH) is the most common form of hyperlipidemia and impacts longevity by promoting ASCVD\, CMD. Conventional ‘omics studies\, designed to find simple associations between genotype and phenotype in large datasets\, are inherently incapable of unraveling the complex pathobiology underlying diseases. Using network analysis\, we aim to describe the effects of the peripheral lipoprotein phenotypes of CH described in a multidimensional space by modules of functional interactions\, using patients from different existing cohorts to understand whether CH drives accelerated biological ageing\, estimated by analysis of the epigenome (DNA-methylation) in conjunction with specific ICD-10 diagnoses and treatments as a function of chronological age. We plan to integrate data of different nature [e.g.\, genetic\, epigenetic\, biochemistry\, national registries\, and electronic health record (EHR)\, and patient reported outcome measures (PROM) questionnaires]. As initial proof-of-concept\, we have created novel multi-source networks in which single-source analyses (i.e.\, liver transcriptomics and epigenomics) are integrated with biochemical parameters and lipoprotein functionality in combination with  Dr. Joseph Loscalzo´s human PPI Personal Protein I. Patients were from the Stockholm Study\, in non-obese\, normolipidemic\, gallstone patients (66% female) were randomized to a 4-week treatment with simvastatin 80 mg/day and ezetimibe 10 mg/day\, alone or in combination\, or to placebo. The first network mining has already indicated a constant and previously unknown interaction between a key gene in cholesterol metabolism and TMBIM6\, a transmembrane protein involved in autophagy and cancer information contained in the multi-source networks. Validation studies of this initial finding in going on in Soat2-only HepG2 cells\, a unique pre-clinical model which more closely resembles human lipoprotein metabolism created by us. \n\n\n\nHost: Olli Kallioniemi\, SciLifeLab Director
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-paolo-parini/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20211004T151500
DTEND;TZID=Europe/Stockholm:20211004T161500
DTSTAMP:20260511T040739
CREATED:20210916T094629Z
LAST-MODIFIED:20210923T122426Z
UID:10000447-1633360500-1633364100@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Ass. Prof. Daniel Espes
DESCRIPTION:SciLifeLab Fellow at Uppsala University \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\nDaniel Espes received his completed his PhD at the Department of Medical Cell Biology\, Uppsala University\, in 2016 and became an Associate Professor (Docent) in Medical Cell Biology in 2019. In parallel with his research career he has worked actively as a clinical physician and became a specialist in internal medicine in 2019. In 2021 Espes joined as a SciLife Fellow and his translational group is focused on the development of clinically applicable techniques for assessing beta-cell mass alterations within the human pancreas during the development of diabetes. \n\n\n\nImagine Imaging Beta-Cell Mass\n\n\n\nType 1 diabetes is one of the most common chronic disease among children and adolescents. Due to the long-term complications associated with the disease the life-expectancy for those living with the disease is reduced by more than 10 years. Type 1 diabetes develops due to progressive loss of the insulin producing beta-cells following an immune attack. However\, the underlying trigger for the immune system is still unknown. At onset of hyperglycemia 60-70% of the beta-cell mass have already been lost\, based on data from autopsy studies. Currently there are no validated techniques for evaluating beta-cell mass in vivo in humans and hence our understanding of how beta-cell mass is altered in health and disease is limited to what we have learned from autopsy material. Our work is focused on establishing novel techniques for the quantification of beta-cell mass in order to increase our understanding of how diabetes develops as well as how beta-cell mass adapts in response to other conditions. In addition\, we are trying to better understand the immunological and metabolic interactions within the pancreas by combining imaging techniques with functional assessments. \n\n\n\nHost: Ass. Prof. Gustaf Christoffersson
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-assoc-prof-daniel-espes/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210928T151500
DTEND;TZID=Europe/Stockholm:20210928T163000
DTSTAMP:20260511T040739
CREATED:20210923T094943Z
LAST-MODIFIED:20210923T122525Z
UID:10000453-1632842100-1632846600@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Prof. Ana Pombo
DESCRIPTION:MDC Berlin Institute for Medical Systems Biology (BIMSB) \, Humboldt University\, Germany \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\nAna Pombo investigates mechanisms that regulate 3D genome folding and gene expression during mammalian  development and in disease. After her doctorate work at the University of Oxford (UK)\, Ana was a recipient of a Royal Society Dorothy Hodgkin Fellowship. She started her independent group in 2000\, at the MRC London Institute for Medical Sciences\, Imperial College London\, before moving to the Max Delbrueck Center for Molecular Medicine in Berlin\, in Germany. Ana received the Robert Feulgen Prize in 2007\, and was elected EMBO member in 2018. She is a Professor at the Humboldt University of Berlin and the Deputy Scientific Directed of the Berlin Institute for Medical Systems Biology at MDC. \n\n\n\nFunctional specialization of 3D genome structures in brain cell types\n\n\n\nDuring lineage commitment\, cells sustain cascades of gene activation and repression to generate specific cell types that execute specialized functions. To investigate the variability of the 3D conformation of the genome in different cell types and their relation with cell-type specific patterns of gene expression\, we applied Genome Architecture Mapping is specific brain cell types from the adult murine brain\, without disturbing their native tissue environment: dopaminergic neurons (DNs) from the midbrain\, pyramidal glutamatergic neurons (PGNs) from the hippocampus\, and oligodendrocyte lineage cells (OLGs) from the cortex. We find extensive reorganization of genome topology\, which the reorganization of topological domains\, chromatin compartments and specific long-range hubs of contacts between neuron-specific genes. We also discover events of extensive chromatin decondensation\, or ‘melting’\, at long neuronal genes when they are highly transcribed\, many of them associated with neurodevelopmental disorders or neurodegeneration. Our work shows that the 3D organization of the genome is highly specific of cell type and strongly related with gene expression programs.Read more about Ana Pombo`s research: https://www.mdc-berlin.de/pomboHost:  Eva Brinkman\, KI
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-ana-pombo/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210920T151500
DTEND;TZID=Europe/Stockholm:20210920T163000
DTSTAMP:20260511T040739
CREATED:20210816T082333Z
LAST-MODIFIED:20210916T154406Z
UID:10000407-1632150900-1632155400@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Assoc. Prof. Daniel Globisch
DESCRIPTION:SciLifeLab Fellow at Uppsala University / Dept. Chem – BMC \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\nAssociate Professor Daniel Globisch started his independent research group as a Science For Life Laboratory Fellow at Uppsala University. In December 2020\, Daniel Globisch received tenure and moved with his laboratory to the Department of Chemistry – BMC. He received his PhD in Organic Chemistry and Chemical Biology in 2011 at the Ludwig-Maximilians-University in Munich and joined The Scripps Research Institute\, La Jolla\, CA for his postdoctoral research in Chemical Biology and Metabolomics from 2011 to 2015. At Uppsala University\, his laboratory develops new Chemical Biology methodologies to extend the scope of metabolomics research to discover new biomarkers for pancreatic and colorectal cancer. The interdisciplinary nature of the research projects is focussed on elucidation of the metabolic interaction between the gut microbiota and their human host. \n\n\n\nExploring Gut Microbiota Metabolism – Unique Chemical Biology Tools for Metabolomics Analysis\n\n\n\nOne of the most exciting scientific developments in the past decade has been the understanding that the microbiome profoundly impacts human physiology. The complex consortium of trillions of microbes possesses a wide range of metabolic activity. This metabolic interspecies communication represents a tremendous opportunity for the discovery of unknown bioactive molecules as only limited information on this co-metabolism has been elucidated on a molecular level. Metabolomics holds a great potential for the discovery of unknown biomarkers and bioactive metabolites. Advanced Chemical Biology tools are limited compared to other ‘omics research fields. Especially\, the detailed analysis of microbial metabolism remains a major challenge and requires advanced techniques. We have developed unique Chemical Biology methodologies for enhanced analysis using liquid chromatography-coupled with tandem mass spectrometry. These tools overcome limitations in mass spectrometry-based metabolomics analysis. We apply these methods for the discovery of unknown metabolites in human samples collected from pancreatic cancer patients to evaluate their potential as biomarkers.
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-assoc-prof-daniel-globisch/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210913T161500
DTEND;TZID=Europe/Stockholm:20210913T173000
DTSTAMP:20260511T040739
CREATED:20210830T090518Z
LAST-MODIFIED:20210907T143831Z
UID:10000419-1631549700-1631554200@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Dr. Aviv Regev
DESCRIPTION:Genentech\, USA \n\n\n\nHost: Erik Sonnhammer \, Stockholm University \n\n\n\nZOOM LINK  \n\n\n\n\n\n\n\n\n\nAviv Regev is a leader in deciphering molecular circuits that govern cells\, tissues and organs in health and their malfunction in disease. Her lab has pioneered foundational experimental and computational methods in single-cell genomics\, working toward greater understanding of the function of cells and tissues in health and disease\, including autoimmune disease\, inflammation and cancer \n\n\n\nCell atlases as roadmaps in health and disease\n\n\n\nCells are the basic unit of life\, and form a key intermediate between genotype and phenotype\, that is essential to explain how the gene variants that contribute to disease risk act. The recent advent of methods for high-throughput single-cell and spatial profiling has opened the way to create a human cells atlas: comprehensive reference maps of all human cells as a basis for both understanding human health and diagnosing\, monitoring\, and treating disease. From such maps we recovered rich aspects of biology\, including cell types and states\, differentiation and other temporal processes\, gene programs\, the physical location and interactions between cells\, the underlying regulatory circuits\, and even the possibility of predicting cell types and behaviors\, towards a “periodic table of our cells”. These\, in turn give us a new vocabulary for disease studies to determine the way in which cells do disease genes act\, which cells are disrupted in disease\, which programs change in them\, what mechanisms underlie their (dis)regulation\, how their cell-cell communications affected\, and what would be the impact of therapies. In this talk\, I will focus on how atlases help us to understand the relation between genotype to phenotype\, especially in the context of human genetics and disease\, from cells\, to programs\, to deciphering individual gene functions\, using single cell genomics as a conceptual and technical framework\, in complex disease\, cancer\, and COVID-19.Read more about Prof. Regev´s research HERE
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-regev-aviv/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210823T151500
DTEND;TZID=Europe/Stockholm:20210823T163000
DTSTAMP:20260511T040739
CREATED:20210816T071003Z
LAST-MODIFIED:20210816T093408Z
UID:10000406-1629731700-1629736200@www.scilifelab.se
SUMMARY:SciLifeLab The Svedberg seminar: Prof. Athula Attygalle
DESCRIPTION: Stevens Institute of Technology\, USA \n\n\n\n\n\n\n\n\n\nLINK TO SEMINAR \n\n\n\n Prof. Athula Attygalle obtained a PhD in Chemistry from Keele University in 1983. After his doctorate\, Attygalle was awarded a Fellowship by the Humboldt Foundation to conduct research at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) under late Prof\, Hans Jürgen Bestmann\, a pioneer in the field of insect pheromone synthesis. Four years at FAU\, provided the impetus for Attygalle to become an expert in high-resolution mass spectrometry and micro-chemical techniques for structure elucidation of natural compounds at nanogram level. At FAU\, Attygalle championed in the area of lepidopteran sex pheromone identification. Attygalle was a visiting professor at University of Houston\, Texas and he has served as the Director of Mass Spectrometry facility at Cornell University. He has completed work there in GC-MS regarding insect substances and their identifications.  Currently Attygalle is attached to the Stevens Institute of Technology as a Research Professor in the Department of Chemistry and head of the mass spectrometry laboratory. Attygalle was the recipient of the 2014 ‘Inventor of the Year’ award presented by the New Jersey Inventors Hall of Fame for his patented work in Mass Spectrometric Analysis utilizing Helium Plasma and charge exchange ionization techniques. Attygalle co-authored the 1999 article “Single-Site Catalysts for Ring-Opening Polymerization:  Synthesis of Heterotactic Poly(lactic acid) from rac-Lactide” in the Journal of the American Chemical Society\, which has been widely cited. \n\n\n\nMultiple Personalities of Gaseous Ions \n\n\n\nFor mass spectrometry\, neutral molecules are converted to gaseous ions.   A mass spectrum is recorded by determining the mass-to-charge ratios and intensities of fragment ions generated by activating a specific ion. Many textbooks provide rules to identify molecules by interpreting their mass spectra.  All recommended interpretations start by presuming a specific structure for the initial ion.  However\, recent advances in ion-mobility methods demonstrate that an ensemble of ions with different structures are produced upon ionization. For example\, the most widely used electrospray ionization technique often generates a mixture of tautomeric forms of a precursor molecule.  Because fragmentation spectra of individual tautomers are often different from each other\, the spectra recorded without separating the isomeric mixtures are composites.  Although large collections of spectra are available as libraries\, the time has come to for us query of the quality of these compilations.                    \n\n\n\nHost: Kumari Ubhayasekera
URL:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminar-prof-athula-attygalle/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210524T151500
DTEND;TZID=Europe/Stockholm:20210524T163000
DTSTAMP:20260511T040739
CREATED:20210521T083002Z
LAST-MODIFIED:20210521T094043Z
UID:10000390-1621869300-1621873800@www.scilifelab.se
SUMMARY:SciLifeLab The Svedberg seminar: Ehab Abouheif
DESCRIPTION:Prof. Ehab Abouheif\n\n\n\nDepartment of Biology\, McGill University\, Canada \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\nAbouheif received a PhD in Biology from Duke University in 2002\, and from 2002 to 2004\, he completed his postdoctoral studies at the University of Chicago and at the University of California\, Berkeley. In 2004 Abouheif was appointed Assistant Professorship at McGill University as Canada Research Chair (tier 2) in Evolutionary Developmental Biology. Currently\, he is a James McGill Professor in the Department of Biology at McGill University. He is a pioneer of eco-evo-devo\, a field that integrates the concepts and technical tools of ecology\, evolutionary\, and developmental biology. Abouheif focuses on ant societies to understand the origins and evolution of complex biological systems. He served as founding President of the Pan-American Society for Evolutionary Developmental Biology and is currently Editor-in-Chief of JEZ-B: Molecular and Developmental Evolution\, one of the main journals in his field. \n\n\n\nDarwin’s invisible ink: The storage and release of ancestral genetic potential in complex biological systems\n\n\n\nAncestral and dormant genetic potentials exist in all animals\, as reflected by the sporadic appearance of ancestral traits in individuals that normally should not have them\, such as teeth in a chicken or hindlimbs in a whale. Such individuals are traditionally thought to be “freaks” that contribute little to the evolutionary process. Abouheif’s lab\, using supersoldier ants as their model\, has changed this traditional view by demonstrating that evolution can harness dormant genetic potentials after they have been released by certain environmental triggers. His lab also demonstrated that rudimentary organs\, like the human appendix\, are not functionless. Rather\, they can play key regulatory functions during development and store this ancestral genetic  potential over millions of years. These discoveries open up future possibilities for harnessing dormant genetic potentials to advance medicine\, biodiversity conservation\, and animal/plant breeding. \n\n\n\nHost: Arild HusbyRead more about Ehab Abouheif´s research
URL:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminar-ehab-abouheif/
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
LOCATION:
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210524T151500
DTEND;TZID=Europe/Stockholm:20210524T161500
DTSTAMP:20260511T040739
CREATED:20210518T081818Z
LAST-MODIFIED:20210524T113122Z
UID:10000386-1621869300-1621872900@www.scilifelab.se
SUMMARY:SciLifeLab The Svedberg seminar: Prof. Ehab Abouheif
DESCRIPTION:Ehab Abouheif\n\n\n\nDepartment of Biology\, McGill University\, Canada \n\n\n\nLINK TO SEMINAR \n\n\n\n Abouheif received a PhD in Biology from Duke University in 2002\, and from 2002 to 2004\, he completed his postdoctoral studies at the University of Chicago and at the University of California\, Berkeley. In 2004 Abouheif was appointed Assistant Professorship at McGill University as Canada Research Chair (tier 2) in Evolutionary Developmental Biology. Currently\, he is a James McGill Professor in the Department of Biology at McGill University. He is a pioneer of eco-evo-devo\, a field that integrates the concepts and technical tools of ecology\, evolutionary\, and developmental biology. Abouheif focuses on ant societies to understand the origins and evolution of complex biological systems. He served as founding President of the Pan-American Society for Evolutionary Developmental Biology and is currently Editor-in-Chief of JEZ-B: Molecular and Developmental Evolution\, one of the main journals in his field. \n\n\n\nDarwin’s invisible ink: The storage and release of ancestral genetic potential in complex biological systems\n\n\n\nAncestral and dormant genetic potentials exist in all animals\, as reflected by the sporadic appearance of ancestral traits in individuals that normally should not have them\, such as teeth in a chicken or hindlimbs in a whale. Such individuals are traditionally thought to be “freaks” that contribute little to the evolutionary process. Abouheif’s lab\, using supersoldier ants as their model\, has changed this traditional view by demonstrating that evolution can harness dormant genetic potentials after they have been released by certain environmental triggers. His lab also demonstrated that rudimentary organs\, like the human appendix\, are not functionless. Rather\, they can play key regulatory functions during development and store this ancestral genetic  potential over millions of years. These discoveries open up future possibilities for harnessing dormant genetic potentials to advance medicine\, biodiversity conservation\, and animal/plant breeding. \n\n\n\nHost: Arild Husby \n\n\n\nRead more about Ehab Abouheif´s research
URL:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminars-prof-ehab-abouheif/
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
LOCATION:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminars-prof-ehab-abouheif/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210518T151500
DTEND;TZID=Europe/Stockholm:20210518T161500
DTSTAMP:20260511T040739
CREATED:20210428T094603Z
LAST-MODIFIED:20210512T085641Z
UID:10000369-1621350900-1621354500@www.scilifelab.se
SUMMARY:Statistical and machine learning techniques in microbiome research
DESCRIPTION:Leo Lahti\n\n\n\nDepartment of Computing\, University of Turku\, Turku\, Finland \n\n\n\nLINK TO SEMINAR \n\n\n\nLeo Lahti is associate professor in data science in University of Turku\, Finland. After completing his PhD in Aalto University\, Finland\, in 2010 he carried out several years of postdoctoral research in The Netherlands and Belgium on population studies of the human microbiome. Lahti has organized various international training events in microbiome bioinformatics\, and he is the Finnish coordinator of the COST action on statistical and machine learning methods in microbiome studies. \n\n\n\nStatistical and machine learning techniques in microbiome research\n\n\n\nThe diverse microbial communities living in human body have a profound influence on our well-being. Human microbiome research has expanded rapidly following the recent advances in high-throughput DNA sequencing and other omics’ technologies. Consequently\, the demand for targeted computational methods has increased significantly in the recent years. We have a limited understanding of the overall mechanisms that control the observed variation and activity of these microbial ecosystems. Our observations have contributed to the systematic characterization of the individual dynamics and population variation of the human microbiome. I will discuss contemporary topics in statistical analysis and machine learning related to microbiome research\, with a specific emphasis on probabilistic latent variable models in understanding the individual and dynamic variation across the landscape of microbiome composition. \n\n\n\nHost: Anders Andersson \n\n\n\nRead more about Leo Lahti´s research
URL:https://www.scilifelab.se/event/statistical-and-machine-learning-techniques-in-microbiome-research/
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
LOCATION:https://www.scilifelab.se/event/statistical-and-machine-learning-techniques-in-microbiome-research/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210510T131500
DTEND;TZID=Europe/Stockholm:20210510T140000
DTSTAMP:20260511T040739
CREATED:20210428T092922Z
LAST-MODIFIED:20210507T075745Z
UID:10000367-1620652500-1620655200@www.scilifelab.se
SUMMARY:A more sustainable chemistry with elemental sulfur
DESCRIPTION:Thanh Binh Nguyen\n\n\n\nUniversité Paris-Saclay\, France\n\n\n\nLINK TO THE SEMINAR\n\n\n\nAbstract\n\n\n\nFacing a more and more rapid depletion of natural resources\, one of the most challenging problems to be solved of modern organic chemistry is to develop reactions enabling access to target molecules from simple and readily available starting materials with higher efficiency in number of atoms while reducing the number of steps\, unnecessary redox changes and waste. With this idea in mind\, we have been concentrating on the use of elemental sulfur – an abundant waste of oil and gas industry with annual product up to 70 MT –  as a polyvalent synthetic tool. This lecture will focus on organic redox reactions developed in our laboratory involving this element as a new synthetic strategy that satisfies most of the requirements of a more sustainable chemistry. \n\n\n\nBiography\n\n\n\nThanh Binh Nguyen received his BS degree (2004) from the University of Natural Sciences in Hochiminh city\, Vietnam and subsequently his MS (2005) and PhD degrees (2008) from the the Université du Maine – Le Mans -France. After a two-year postdoctoral stay at the Institut de Chimie des Substances Naturelles – Gif-sur-Yvette – France\, he obtained a permanent research associate position (Chargé de Recherche) of the Centre National de la Recherche Scientifique (CNRS) in 2011\, working in the same institute. His main research interest is the development of new synthetic methods for carbon-nitrogen bond formation with a strong emphasis on using elemental sulfur\, molecular iodine and iron–sulfur catalysts. \n\n\n\nHost\n\n\n\nDuc Duy Vo\, Uppsala University
URL:https://www.scilifelab.se/event/a-more-sustainable-chemistry-with-elemental-sulfur/
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
LOCATION:https://uu-se.zoom.us/j/65768822626
END:VEVENT
END:VCALENDAR