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BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210928T151500
DTEND;TZID=Europe/Stockholm:20210928T163000
DTSTAMP:20210923T122525Z
CREATED:20210923T094943Z
LAST-MODIFIED:20210923T122525Z
UID:10000453-1632842100-1632846600@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Prof. Ana Pombo
DESCRIPTION:MDC Berlin Institute for Medical Systems Biology (BIMSB) \, Humboldt University\, Germany \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\nAna Pombo investigates mechanisms that regulate 3D genome folding and gene expression during mammalian  development and in disease. After her doctorate work at the University of Oxford (UK)\, Ana was a recipient of a Royal Society Dorothy Hodgkin Fellowship. She started her independent group in 2000\, at the MRC London Institute for Medical Sciences\, Imperial College London\, before moving to the Max Delbrueck Center for Molecular Medicine in Berlin\, in Germany. Ana received the Robert Feulgen Prize in 2007\, and was elected EMBO member in 2018. She is a Professor at the Humboldt University of Berlin and the Deputy Scientific Directed of the Berlin Institute for Medical Systems Biology at MDC. \n\n\n\nFunctional specialization of 3D genome structures in brain cell types\n\n\n\nDuring lineage commitment\, cells sustain cascades of gene activation and repression to generate specific cell types that execute specialized functions. To investigate the variability of the 3D conformation of the genome in different cell types and their relation with cell-type specific patterns of gene expression\, we applied Genome Architecture Mapping is specific brain cell types from the adult murine brain\, without disturbing their native tissue environment: dopaminergic neurons (DNs) from the midbrain\, pyramidal glutamatergic neurons (PGNs) from the hippocampus\, and oligodendrocyte lineage cells (OLGs) from the cortex. We find extensive reorganization of genome topology\, which the reorganization of topological domains\, chromatin compartments and specific long-range hubs of contacts between neuron-specific genes. We also discover events of extensive chromatin decondensation\, or ‘melting’\, at long neuronal genes when they are highly transcribed\, many of them associated with neurodevelopmental disorders or neurodegeneration. Our work shows that the 3D organization of the genome is highly specific of cell type and strongly related with gene expression programs.Read more about Ana Pombo`s research: https://www.mdc-berlin.de/pomboHost:  Eva Brinkman\, KI
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-ana-pombo/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210920T151500
DTEND;TZID=Europe/Stockholm:20210920T163000
DTSTAMP:20210916T154406Z
CREATED:20210816T082333Z
LAST-MODIFIED:20210916T154406Z
UID:10000407-1632150900-1632155400@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Assoc. Prof. Daniel Globisch
DESCRIPTION:SciLifeLab Fellow at Uppsala University / Dept. Chem – BMC \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\n\n\nAssociate Professor Daniel Globisch started his independent research group as a Science For Life Laboratory Fellow at Uppsala University. In December 2020\, Daniel Globisch received tenure and moved with his laboratory to the Department of Chemistry – BMC. He received his PhD in Organic Chemistry and Chemical Biology in 2011 at the Ludwig-Maximilians-University in Munich and joined The Scripps Research Institute\, La Jolla\, CA for his postdoctoral research in Chemical Biology and Metabolomics from 2011 to 2015. At Uppsala University\, his laboratory develops new Chemical Biology methodologies to extend the scope of metabolomics research to discover new biomarkers for pancreatic and colorectal cancer. The interdisciplinary nature of the research projects is focussed on elucidation of the metabolic interaction between the gut microbiota and their human host. \n\n\n\nExploring Gut Microbiota Metabolism – Unique Chemical Biology Tools for Metabolomics Analysis\n\n\n\nOne of the most exciting scientific developments in the past decade has been the understanding that the microbiome profoundly impacts human physiology. The complex consortium of trillions of microbes possesses a wide range of metabolic activity. This metabolic interspecies communication represents a tremendous opportunity for the discovery of unknown bioactive molecules as only limited information on this co-metabolism has been elucidated on a molecular level. Metabolomics holds a great potential for the discovery of unknown biomarkers and bioactive metabolites. Advanced Chemical Biology tools are limited compared to other ‘omics research fields. Especially\, the detailed analysis of microbial metabolism remains a major challenge and requires advanced techniques. We have developed unique Chemical Biology methodologies for enhanced analysis using liquid chromatography-coupled with tandem mass spectrometry. These tools overcome limitations in mass spectrometry-based metabolomics analysis. We apply these methods for the discovery of unknown metabolites in human samples collected from pancreatic cancer patients to evaluate their potential as biomarkers.
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-assoc-prof-daniel-globisch/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210913T161500
DTEND;TZID=Europe/Stockholm:20210913T173000
DTSTAMP:20210907T143831Z
CREATED:20210830T090518Z
LAST-MODIFIED:20210907T143831Z
UID:10000419-1631549700-1631554200@www.scilifelab.se
SUMMARY:The Svedberg seminar series: Dr. Aviv Regev
DESCRIPTION:Genentech\, USA \n\n\n\nHost: Erik Sonnhammer \, Stockholm University \n\n\n\nZOOM LINK  \n\n\n\n\n\n\n\n\n\nAviv Regev is a leader in deciphering molecular circuits that govern cells\, tissues and organs in health and their malfunction in disease. Her lab has pioneered foundational experimental and computational methods in single-cell genomics\, working toward greater understanding of the function of cells and tissues in health and disease\, including autoimmune disease\, inflammation and cancer \n\n\n\nCell atlases as roadmaps in health and disease\n\n\n\nCells are the basic unit of life\, and form a key intermediate between genotype and phenotype\, that is essential to explain how the gene variants that contribute to disease risk act. The recent advent of methods for high-throughput single-cell and spatial profiling has opened the way to create a human cells atlas: comprehensive reference maps of all human cells as a basis for both understanding human health and diagnosing\, monitoring\, and treating disease. From such maps we recovered rich aspects of biology\, including cell types and states\, differentiation and other temporal processes\, gene programs\, the physical location and interactions between cells\, the underlying regulatory circuits\, and even the possibility of predicting cell types and behaviors\, towards a “periodic table of our cells”. These\, in turn give us a new vocabulary for disease studies to determine the way in which cells do disease genes act\, which cells are disrupted in disease\, which programs change in them\, what mechanisms underlie their (dis)regulation\, how their cell-cell communications affected\, and what would be the impact of therapies. In this talk\, I will focus on how atlases help us to understand the relation between genotype to phenotype\, especially in the context of human genetics and disease\, from cells\, to programs\, to deciphering individual gene functions\, using single cell genomics as a conceptual and technical framework\, in complex disease\, cancer\, and COVID-19.Read more about Prof. Regev´s research HERE
URL:https://www.scilifelab.se/event/the-svedberg-seminar-series-prof-regev-aviv/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210823T151500
DTEND;TZID=Europe/Stockholm:20210823T163000
DTSTAMP:20210816T093408Z
CREATED:20210816T071003Z
LAST-MODIFIED:20210816T093408Z
UID:10000406-1629731700-1629736200@www.scilifelab.se
SUMMARY:SciLifeLab The Svedberg seminar: Prof. Athula Attygalle
DESCRIPTION: Stevens Institute of Technology\, USA \n\n\n\n\n\n\n\n\n\nLINK TO SEMINAR \n\n\n\n Prof. Athula Attygalle obtained a PhD in Chemistry from Keele University in 1983. After his doctorate\, Attygalle was awarded a Fellowship by the Humboldt Foundation to conduct research at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) under late Prof\, Hans Jürgen Bestmann\, a pioneer in the field of insect pheromone synthesis. Four years at FAU\, provided the impetus for Attygalle to become an expert in high-resolution mass spectrometry and micro-chemical techniques for structure elucidation of natural compounds at nanogram level. At FAU\, Attygalle championed in the area of lepidopteran sex pheromone identification. Attygalle was a visiting professor at University of Houston\, Texas and he has served as the Director of Mass Spectrometry facility at Cornell University. He has completed work there in GC-MS regarding insect substances and their identifications.  Currently Attygalle is attached to the Stevens Institute of Technology as a Research Professor in the Department of Chemistry and head of the mass spectrometry laboratory. Attygalle was the recipient of the 2014 ‘Inventor of the Year’ award presented by the New Jersey Inventors Hall of Fame for his patented work in Mass Spectrometric Analysis utilizing Helium Plasma and charge exchange ionization techniques. Attygalle co-authored the 1999 article “Single-Site Catalysts for Ring-Opening Polymerization:  Synthesis of Heterotactic Poly(lactic acid) from rac-Lactide” in the Journal of the American Chemical Society\, which has been widely cited. \n\n\n\nMultiple Personalities of Gaseous Ions \n\n\n\nFor mass spectrometry\, neutral molecules are converted to gaseous ions.   A mass spectrum is recorded by determining the mass-to-charge ratios and intensities of fragment ions generated by activating a specific ion. Many textbooks provide rules to identify molecules by interpreting their mass spectra.  All recommended interpretations start by presuming a specific structure for the initial ion.  However\, recent advances in ion-mobility methods demonstrate that an ensemble of ions with different structures are produced upon ionization. For example\, the most widely used electrospray ionization technique often generates a mixture of tautomeric forms of a precursor molecule.  Because fragmentation spectra of individual tautomers are often different from each other\, the spectra recorded without separating the isomeric mixtures are composites.  Although large collections of spectra are available as libraries\, the time has come to for us query of the quality of these compilations.                    \n\n\n\nHost: Kumari Ubhayasekera
URL:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminar-prof-athula-attygalle/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210524T151500
DTEND;TZID=Europe/Stockholm:20210524T163000
DTSTAMP:20210521T094043Z
CREATED:20210521T083002Z
LAST-MODIFIED:20210521T094043Z
UID:10000390-1621869300-1621873800@www.scilifelab.se
SUMMARY:SciLifeLab The Svedberg seminar: Ehab Abouheif
DESCRIPTION:Prof. Ehab Abouheif\n\n\n\nDepartment of Biology\, McGill University\, Canada \n\n\n\nLINK TO SEMINAR \n\n\n\n\n\n\n\nAbouheif received a PhD in Biology from Duke University in 2002\, and from 2002 to 2004\, he completed his postdoctoral studies at the University of Chicago and at the University of California\, Berkeley. In 2004 Abouheif was appointed Assistant Professorship at McGill University as Canada Research Chair (tier 2) in Evolutionary Developmental Biology. Currently\, he is a James McGill Professor in the Department of Biology at McGill University. He is a pioneer of eco-evo-devo\, a field that integrates the concepts and technical tools of ecology\, evolutionary\, and developmental biology. Abouheif focuses on ant societies to understand the origins and evolution of complex biological systems. He served as founding President of the Pan-American Society for Evolutionary Developmental Biology and is currently Editor-in-Chief of JEZ-B: Molecular and Developmental Evolution\, one of the main journals in his field. \n\n\n\nDarwin’s invisible ink: The storage and release of ancestral genetic potential in complex biological systems\n\n\n\nAncestral and dormant genetic potentials exist in all animals\, as reflected by the sporadic appearance of ancestral traits in individuals that normally should not have them\, such as teeth in a chicken or hindlimbs in a whale. Such individuals are traditionally thought to be “freaks” that contribute little to the evolutionary process. Abouheif’s lab\, using supersoldier ants as their model\, has changed this traditional view by demonstrating that evolution can harness dormant genetic potentials after they have been released by certain environmental triggers. His lab also demonstrated that rudimentary organs\, like the human appendix\, are not functionless. Rather\, they can play key regulatory functions during development and store this ancestral genetic  potential over millions of years. These discoveries open up future possibilities for harnessing dormant genetic potentials to advance medicine\, biodiversity conservation\, and animal/plant breeding. \n\n\n\nHost: Arild HusbyRead more about Ehab Abouheif´s research
URL:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminar-ehab-abouheif/
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
LOCATION:
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210524T151500
DTEND;TZID=Europe/Stockholm:20210524T161500
DTSTAMP:20210524T113122Z
CREATED:20210518T081818Z
LAST-MODIFIED:20210524T113122Z
UID:10000386-1621869300-1621872900@www.scilifelab.se
SUMMARY:SciLifeLab The Svedberg seminar: Prof. Ehab Abouheif
DESCRIPTION:Ehab Abouheif\n\n\n\nDepartment of Biology\, McGill University\, Canada \n\n\n\nLINK TO SEMINAR \n\n\n\n Abouheif received a PhD in Biology from Duke University in 2002\, and from 2002 to 2004\, he completed his postdoctoral studies at the University of Chicago and at the University of California\, Berkeley. In 2004 Abouheif was appointed Assistant Professorship at McGill University as Canada Research Chair (tier 2) in Evolutionary Developmental Biology. Currently\, he is a James McGill Professor in the Department of Biology at McGill University. He is a pioneer of eco-evo-devo\, a field that integrates the concepts and technical tools of ecology\, evolutionary\, and developmental biology. Abouheif focuses on ant societies to understand the origins and evolution of complex biological systems. He served as founding President of the Pan-American Society for Evolutionary Developmental Biology and is currently Editor-in-Chief of JEZ-B: Molecular and Developmental Evolution\, one of the main journals in his field. \n\n\n\nDarwin’s invisible ink: The storage and release of ancestral genetic potential in complex biological systems\n\n\n\nAncestral and dormant genetic potentials exist in all animals\, as reflected by the sporadic appearance of ancestral traits in individuals that normally should not have them\, such as teeth in a chicken or hindlimbs in a whale. Such individuals are traditionally thought to be “freaks” that contribute little to the evolutionary process. Abouheif’s lab\, using supersoldier ants as their model\, has changed this traditional view by demonstrating that evolution can harness dormant genetic potentials after they have been released by certain environmental triggers. His lab also demonstrated that rudimentary organs\, like the human appendix\, are not functionless. Rather\, they can play key regulatory functions during development and store this ancestral genetic  potential over millions of years. These discoveries open up future possibilities for harnessing dormant genetic potentials to advance medicine\, biodiversity conservation\, and animal/plant breeding. \n\n\n\nHost: Arild Husby \n\n\n\nRead more about Ehab Abouheif´s research
URL:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminars-prof-ehab-abouheif/
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
LOCATION:https://www.scilifelab.se/event/scilifelab-the-svedberg-seminars-prof-ehab-abouheif/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210518T151500
DTEND;TZID=Europe/Stockholm:20210518T161500
DTSTAMP:20210512T085641Z
CREATED:20210428T094603Z
LAST-MODIFIED:20210512T085641Z
UID:10000369-1621350900-1621354500@www.scilifelab.se
SUMMARY:Statistical and machine learning techniques in microbiome research
DESCRIPTION:Leo Lahti\n\n\n\nDepartment of Computing\, University of Turku\, Turku\, Finland \n\n\n\nLINK TO SEMINAR \n\n\n\nLeo Lahti is associate professor in data science in University of Turku\, Finland. After completing his PhD in Aalto University\, Finland\, in 2010 he carried out several years of postdoctoral research in The Netherlands and Belgium on population studies of the human microbiome. Lahti has organized various international training events in microbiome bioinformatics\, and he is the Finnish coordinator of the COST action on statistical and machine learning methods in microbiome studies. \n\n\n\nStatistical and machine learning techniques in microbiome research\n\n\n\nThe diverse microbial communities living in human body have a profound influence on our well-being. Human microbiome research has expanded rapidly following the recent advances in high-throughput DNA sequencing and other omics’ technologies. Consequently\, the demand for targeted computational methods has increased significantly in the recent years. We have a limited understanding of the overall mechanisms that control the observed variation and activity of these microbial ecosystems. Our observations have contributed to the systematic characterization of the individual dynamics and population variation of the human microbiome. I will discuss contemporary topics in statistical analysis and machine learning related to microbiome research\, with a specific emphasis on probabilistic latent variable models in understanding the individual and dynamic variation across the landscape of microbiome composition. \n\n\n\nHost: Anders Andersson \n\n\n\nRead more about Leo Lahti´s research
URL:https://www.scilifelab.se/event/statistical-and-machine-learning-techniques-in-microbiome-research/
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
LOCATION:https://www.scilifelab.se/event/statistical-and-machine-learning-techniques-in-microbiome-research/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20210510T131500
DTEND;TZID=Europe/Stockholm:20210510T140000
DTSTAMP:20210507T075745Z
CREATED:20210428T092922Z
LAST-MODIFIED:20210507T075745Z
UID:10000367-1620652500-1620655200@www.scilifelab.se
SUMMARY:A more sustainable chemistry with elemental sulfur
DESCRIPTION:Thanh Binh Nguyen\n\n\n\nUniversité Paris-Saclay\, France\n\n\n\nLINK TO THE SEMINAR\n\n\n\nAbstract\n\n\n\nFacing a more and more rapid depletion of natural resources\, one of the most challenging problems to be solved of modern organic chemistry is to develop reactions enabling access to target molecules from simple and readily available starting materials with higher efficiency in number of atoms while reducing the number of steps\, unnecessary redox changes and waste. With this idea in mind\, we have been concentrating on the use of elemental sulfur – an abundant waste of oil and gas industry with annual product up to 70 MT –  as a polyvalent synthetic tool. This lecture will focus on organic redox reactions developed in our laboratory involving this element as a new synthetic strategy that satisfies most of the requirements of a more sustainable chemistry. \n\n\n\nBiography\n\n\n\nThanh Binh Nguyen received his BS degree (2004) from the University of Natural Sciences in Hochiminh city\, Vietnam and subsequently his MS (2005) and PhD degrees (2008) from the the Université du Maine – Le Mans -France. After a two-year postdoctoral stay at the Institut de Chimie des Substances Naturelles – Gif-sur-Yvette – France\, he obtained a permanent research associate position (Chargé de Recherche) of the Centre National de la Recherche Scientifique (CNRS) in 2011\, working in the same institute. His main research interest is the development of new synthetic methods for carbon-nitrogen bond formation with a strong emphasis on using elemental sulfur\, molecular iodine and iron–sulfur catalysts. \n\n\n\nHost\n\n\n\nDuc Duy Vo\, Uppsala University
URL:https://www.scilifelab.se/event/a-more-sustainable-chemistry-with-elemental-sulfur/
CATEGORIES:Event
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
LOCATION:https://uu-se.zoom.us/j/65768822626
END:VEVENT
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