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DTSTART;TZID=Europe/Stockholm:20221206T110000
DTEND;TZID=Europe/Stockholm:20221206T120000
DTSTAMP:20260403T191212
CREATED:20221201T122659Z
LAST-MODIFIED:20221201T122702Z
UID:10000743-1670324400-1670328000@www.scilifelab.se
SUMMARY:SciLifeLab Uppsala PhD&Postdoc Online Seminar Series – Cancer Theme
DESCRIPTION:Welcome back to the SciLifeLab Uppsala PhD&Postdoc seminar series! \nThis seminar will take place on Tuesday December 6 from 11h to 11:50h on Zoom (https://uu-se.zoom.us/j/66489618700) \nFor this occasion the speakers will be: \n1. Xiaonan Zhang\, Postdoc at Tobias Sjöblom’s Lab (Cancer Precision Medicine)\, Dept. of Immunology\, Genetics and Pathology\, Uppsala University\n\n\nTitle:  Exploiting allelic loss in cancer therapy: Identification of NAT2 and CYP2D6 as potential targets\n\nSummary:\nLoss of heterozygosity (LOH) is observed in >90% of human cancers and results in the loss of allelic variation in thousands of genes. LOH thus creates genetic differences between tumor and normal cells\, particularly at gene loci where the individual is heterozygous for a wildtype and a loss-of-function (LoF) allele. We have sought to identify genes with common LoF polymorphisms where tumor cells that have lost the gene activity can be targeted by low-molecular-weight drugs or other means. We previously reported that recurring LOH at the NAT2 locus at 8p22 in colorectal cancers (CRCs)\, and the ensuing loss of NAT2 enzyme activity\, could be exploited for anticancer therapy. Recently\, we discovered a group of ATPase inhibitors that exhibited specific toxicity to CRC cells with high NAT2 activity. In parallel\, we investigated the CYP2D6 locus as the CYP2D6 enzyme metabolizes ~25% of clinically used drugs and frequently undergoes LOH in several tumor types. We have established liver cancer cell models and demonstrated that the activity of three anti-cancer compounds\, used in clinic or in clinical trials\, is dependent on CYP2D6. We anticipate that a subset of CRC and liver cancer patients with LOH events in NAT2 or CYP2D6 will benefit from this research. \n\n\n\n2. Kehuan Wang\, PhD Student at Carl-Henrik Heldin’s Lab (Cancer)\, Dept. of Medical Biochemistry and Microbiology\, Uppsala University\n\nTitle: The Proteasomal\, Lysosomal and Autophagosomal Degradation Pathways of PDGFRβ\n\nSummary:\n\nPlatelet-derived growth factor (PDGF)-induced signaling via PDGF receptor β (PDGFRβ) leads to activation of downstream signaling pathways which regulate multiple cellular responses\, such cell migration\, proliferation and survival. Signaling via PDGFRβ is dependent on subcellular location of signaling molecules and hence the internalization of the receptor. It is not clear exactly how PDGFRβ is degraded\, both endosomal/lysosomal and proteasomal degradation has been suggested. In this study\, we have characterized the proteolytic cleavage of ligand-induced PDGFRβ and found that proteolytic cleavage of PDGFRβ resulted in two fragments. This cleavage is dependent on the internalization of PDGFRβ\, which can be blocked by the treatment with bortezomib. Treatment with bortezomib resulted in increased phosphorylation of PDGFRβ and the down-stream signaling molecules PLCγ and STAT3\, while phosphorylation of Erk1/2 MAPK was reduced and Akt was unaffected. We also investigated the possibility that PDGFRβ is degraded by selective autophagy in response to starvation or ligand-induced downregulation of receptor from the cell surface. We found that PDGFRβ accumulated in cells treated with bafilomycin A1 upon serum starvation which could be reversed by inhibition of protein synthesis with cycloheximide. Overexpression of LC3A\, but not LC3B\, promoted the formation of a complex between PDGFRβ and p62. Additionally\, PDGFRβ interacted with LC3A and other members of LC3-like family\, i.e. GABARAP and GABARAPL1. In conclusion\, we speculate that the step-wise proteolytic cleavage of PDGFRβ may have functional consequences for signaling. Macroautophagy may not play a major role in ligand-induced downregulation of PDGFRβ but it could be involved in downregulation of PDGFRβ during starvation via targeting by p62 to non-conventional autophagic or proteasomal pathways that include LC3A and GABARAPs. The functional involvement of these pathways in the control of PDGFRβ levels remains to be further investigated.
URL:https://www.scilifelab.se/event/scilifelab-uppsala-phdpostdoc-online-seminar-series-cancer-theme/
LOCATION:Online event via Zoom
CATEGORIES:Community
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/11/SciLifeLab-PhDPostdoc-conuncil-poster_landscape_December_6.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221124T090000
DTEND;TZID=Europe/Stockholm:20221124T170000
DTSTAMP:20260403T191212
CREATED:20221019T130435Z
LAST-MODIFIED:20221117T161827Z
UID:10000715-1669280400-1669309200@www.scilifelab.se
SUMMARY:SciLifeLab Platform Day - Uppsala site
DESCRIPTION:This day will be held to promote and introduce an array of SciLifeLab infrastructure platforms based in Uppsala. \nVenue: Trippelrummet\, and on ZoomTime: 9:00-17:00 \n\n\nREGISTER HERE\n\n\n\nSEE THE PROGRAM HERE
URL:https://www.scilifelab.se/event/scilifelab-platform-day/
LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden
CATEGORIES:Event
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221108T110000
DTEND;TZID=Europe/Stockholm:20221108T120000
DTSTAMP:20260403T191212
CREATED:20221107T151644Z
LAST-MODIFIED:20221107T151703Z
UID:10000726-1667905200-1667908800@www.scilifelab.se
SUMMARY:SciLifeLab Uppsala PhD&Postdoc Online Seminar Series - Immunology Theme
DESCRIPTION:Welcome back to the SciLifeLab Uppsala PhD&Postdoc seminar series!\n\nThis seminar will take place on Tuesday November 8th from 11h to 11:50h on Zoom (https://uu-se.zoom.us/j/66489618700)\n\nFor this occasion the speakers will be:\n\n1. Tiarne van de Walle\, PhD Student at Anna Dimberg and Magnus Essand’s Labs (Vascular Biology & Cancer Immunotherapy)\, Dept. of Immunology\, Genetics and Pathology\, Uppsala University\n\nTitle: Shining the LIGHT on Glioblastoma\n\nSummary:\nGlioblastoma is the most aggressive primary brain cancer and is resistant to immunotherapy\, which is largely due to poor T cell infiltration. Here\, we screened a panel of lymphoneogenic cytokines\, from which we selected LIGHT/TNFSF14 as the most promising candidate for treatment of glioma. Then\, we utilized a brain endothelial cell-targeted vector to express LIGHT on the glioma vasculature. Systemic treatment with this novel therapeutic agent resulted in prolonged survival\, and promoted efficient T cell infiltration and anti-tumour immune responses. As such\, our work demonstrates that tailoring the vascular phenotype through vessel-targeted expression of LIGHT is a promising therapeutic strategy\, which has broader implications for treatment of other immunotherapy-resistant cancers.\n\n \n\n\n2. Miguel Vizoso Patiñoi\, Researcher at Mia Phillipson’s Lab (Immunology)\, Dept. of Medical Cell Biology\, Uppsala University\n\nTitle: Uncovering the role of the innate immune cells in vascular remodeling during menstruation and associated pathologies\n\nSummary:\nMore than 10% of women worldwide suffer from abnormal uterine bleeding (AUB). Current standardized therapies for AUB include ovulation blockade and hysterectomy\, which both are highly aggressive and interfere with fertility. Thus\, there is an unmet clinical need for more effective and non-invasive treatments. The scarcity of efficient therapies is at least partly due to the lack of reproductive experimental models\, as well as that the underlying mechanisms resulting in AUB are largely unknown. However\, innate immune cells have been documented to be actively recruited to the endometrium during physiological menstrual cycle and pregnancy. Based on our recent discoveries of a pro-angiogenic subpopulation of neutrophils\, in addition to novel functions of macrophages important for blood-vessel maturation\, I will in this project\, define the contribution of innate immune cells in the vascular phenotype of AUB. The main goals addressed by 2 work packages (WPs) are:\n\n\nTo develop the first humanized murine uterus to characterize how human endometrial epithelial cells (hEECs) participate of the vascular network remodeling in vivo. To this end\, EECs from healthy and AUB donors will be orthotopically transplanted in immunocompromised mice and its impact on vasculature remodeling will be measurable in real time by intravital microscopy upon menstrual cycle induction. Samples will be also submitted for scRNAseq to reveal the transcriptomic networks connecting the epithelium (human-origin) and stroma/endothelium (murine-origin) compartments at different time points of the menstrual cycle.\nTo assess whether the role of the innate immune cells in endometrial angiogenesis and vascular pruning differs depending on their interaction with healthy or pathogenic (AUB) derived hEECs.\n\nThus\, this project will provide a novel model to study endometrial human physiology in vivo\, to enable the discovery of new mechanisms involved in AUB. Generated insights will then be used to pursue opportunities to translate the findings into clinical practice and provide non-invasive therapies to treat AUB disorders.
URL:https://www.scilifelab.se/event/scilifelab-uppsala-phdpostdoc-online-seminar-series-immunology-theme/
LOCATION:Online event via Zoom
CATEGORIES:Community
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/11/SciLifeLab-PhDPostdoc-conuncil-poster_landscape_November_08.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220607T110000
DTEND;TZID=Europe/Stockholm:20220607T120000
DTSTAMP:20260403T191212
CREATED:20220602T155036Z
LAST-MODIFIED:20220603T141658Z
UID:10000622-1654599600-1654603200@www.scilifelab.se
SUMMARY:SciLifeLab Uppsala PhD&Postdoc seminar
DESCRIPTION:ZOOM link\n\n\n\n\n\n\n\nWelcome to SciLifeLab Uppsala PhD&Postdoc seminars! \nWe are very happy to host exciting talks by PhD students and Postdocs from a great variety of fields within SciLifeLab. \n \nSpeaker 1: Gustav Arvidsson\, Researcher at Jessica Nordlund Lab (Molecular Precision Medicine)\, Dept. of Medical Sciences \nTitle: B-cells in primary Sjögren’s syndrome studied by scRNA-seqSummary: Primary Sjögren’s syndrome (pSS) is an autoimmune disease where the main clinical indication is an increased lymphocyte infiltration to the salivary and lacrimal glands\, leading to a dry mouth and dry eyes. Auto-antibodies to SSA or SSB are present in the majority of the cases and these can often be detected long before symptoms arise. The disease primarily affects middle aged women and while the disease manifestation is mild for most patients about a third develop more severe systemic symptoms and 5% of the patients develop B-cell lymphomas. Given the prominent role of B-cells in the onset and progression of pSS the present study aims to interrogate differences in B-cell subtype composition\, clonotype distribution and gene expression differences between patient subgroups for different B-cell subtypes by means of scRNA-seq. For this purpose\, we have generated gene expression and targeted B-cell receptor libraries for ~230 000 unique purified B-cells from 24 patients and healthy controls which we hope can broaden the understanding of the role of B-cells in pSS. \nSpeaker 2: David Lagman\, Researcher at Dan Larhammar Lab(Pharmacology)\, Dept. of Medical Cell Biology \nTitle: Evolution of genes important for nervous system function in vertebrates with a focus on visionSummary: Whole genome duplications (WGDs) at the base of the vertebrate lineage have over the years been shown to be responsible for the expansion of many gene families that are important in vertebrate central nervous system function. We have previously resolved the evolution of many of these genes in relation to these WGDs\, especially those involved in neuronal\, neuroendocrine\, and visual function. Here\, I will describe our latest results regarding the evolution of cyclic nucleotide gated cation (CNG) channel genes in metazoans. The CNG channels play an important role in vision in vertebrates by being responsible for the hypopolarization of cone and rod photoreceptor cells after the detection of light. Using extensive datamining we have managed to identify four previously unknown CNG channel genes in several invertebrate lineages. We have also managed to\, through detailed analyses of conserved synteny\, accurately assign vertebrate CNG genes to related chromosomal regions providing strong evidence for an expansion in the early vertebrate WGDs. These analyses open up the door for investigations into the function of the novel CNG genes identified in invertebrate genomes. Finally\, I will describe our current endeavor into understanding the evolution of genes involved in long term memory formation and maintenance in vertebrates.
URL:https://www.scilifelab.se/event/scilifelab-uppsala-phdpostdoc-seminar-2/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/05/SciLifeLab-PhDPostdoc-conuncil-poster_landscape_June_07.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220524T110000
DTEND;TZID=Europe/Stockholm:20220524T115000
DTSTAMP:20260403T191212
CREATED:20220520T144620Z
LAST-MODIFIED:20220520T145411Z
UID:10000613-1653390000-1653393000@www.scilifelab.se
SUMMARY:SciLifeLab Uppsala PhD&Postdoc seminar
DESCRIPTION:Welcome to SciLifeLab Uppsala PhD&Postdoc seminars! \nWe are very happy to host exciting talks by PhD students and Postdocs from a great variety of fields within SciLifeLab. \n\n \n\n\n\nSpeaker 1: Hongxing Zhao\, Researcher at Ulf Landegren Lab (Molecular Tools)\, Dept. of Immunology\, Genetics and Pathology\n\n\n\nTitle: Detection of SARS-CoV-2 antibodies from dried blood spots of vaccine individuals by proximity extension assay Summary: We have developed a solution-phase assay for sensitive detection of SARS-CoV-2 antibodies in serum or dried blood spots (DBS) from infected or vaccinated individuals. Detection probes were prepared by conjugating the recombinant S1-RBD or nucleocapsid (NC) to either of a pair of oligonucleotides. Upon incubation with COVID-19 patient serum or DBS from vaccinated individuals\, the multivalency of the antibodies brings pairs of oligonucleotides that have been conjugated to the viral proteins in proximity. The oligonucleotides can then undergo enzymatic DNA extension via a proximity extension assay (PEA)\, and the resulting amplicons are sensitively detected by real-time PCR or end-point read out using ELISA mechine. This antibody PEA (AbPEA) test uses only 1 µl neat or diluted serum or one ø1.2 mm disc cut from a DBS. All 100 investigated sera and 21 DBS collected prior to the COVID-19 outbreak were negative\, demonstrating a 100% specificity. The sensitivity of the assay for infected patient after 10 days symptom reached 99.8% [95% confidence interval: 0.9935-1]. Anti-S1 antibodies could be detected directly in punched-out discs from self-sampled DBS 11 days after vaccination\, and it reached a maximum at 3 weeks after a first inoculation. Examination of a serially collected DBS from 14 individuals all showed similar trends of antibody responses after both a first and second vaccination\, although antibody levels varied between individuals. \n\n\n\nSpeaker 2: Manon Dubol\, PhD. Postdoctoral Researcher at Erika Comasco Neuropsychopharmacology Group\, Dept. of Women and Children’s Health\n\n\n\n\n\n\n\nTitle: Grey matter morphometry and MRI data-driven classification of premenstrual dysphoric disorder (PMDD) Summary: Premenstrual dysphoric disorder (PMDD) is recognized in the DSM-5 as a hormone-related depressive disorder\, specific to women’s mental health 1. Women who suffer from PMDD experience affective\, cognitive\, and physical symptoms that peak during the late luteal phase of the menstrual cycle\, and remit shortly in the beginning of the next cycle 2. The key affective symptoms of PMDD point to anatomical and functional brain impairment\, suggesting an impaired top-down inhibitory process involving limbic brain structures 3. However\, very little is known about brain morphological alterations in PMDD. The present study aimed at investigating the grey matter structures that distinguish women with PMDD from healthy controls\, by use of multiscale structural MRI analyses. Differences in grey matter structure between the groups were investigated by use of Voxel- and Surface Based Morphometry. Furthermore\, machine learning and multivariate pattern analysis was performed using a leave-one-fold-out cross-validation procedure\, to test whether MRI measures (volume\, thickness\, gyrification\, sulcal depth and cortical complexity) could distinguish women with PMDD from healthy controls. The findings point to PMDD-specific grey matter structure in regions of corticolimbic networks\, in line with the hypothesis of an impaired top-down inhibitory circuit involving limbic structures in PMDD. Furthermore\, the results include widespread cortical regions and cerebellar areas\, suggesting the involvement of distinct networks in PMDD pathophysiology. These effects prominently involved volumetric and cortical thickness measures\, as further highlighted by multivariate pattern classification analyses. Such differences in brain structure may help explaining the variations in brain function previously reported in women with PMDD during the symptomatic phase.
URL:https://www.scilifelab.se/event/scilifelab-uppsala-phdpostdoc-seminar/
LOCATION:Online event via Zoom
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/05/SciLifeLab-PhDPostdoc-conuncil-poster_landscape_May_24.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220510T110000
DTEND;TZID=Europe/Stockholm:20220510T113000
DTSTAMP:20260403T191212
CREATED:20220505T144221Z
LAST-MODIFIED:20220505T145612Z
UID:10000602-1652180400-1652182200@www.scilifelab.se
SUMMARY:SciLifeLab Uppsala PhD&Postdoc seminar
DESCRIPTION:Welcome to SciLifeLab Uppsala PhD&Postdoc seminars! \n\n\n\nWe are very happy to host exciting talks by PhD students and Postdocs from a great variety of fields within SciLifeLab. \n\n\n\nSpeaker: Jinlin Li\, Researcher at the Heparan Sulfate Biology group (Jinlin Li’s lab)\, Dept. of Medical Biochemistry and MicrobiologyTitle: Heparanase attenuates ZIKV infection by impeding the stability of viral protein \n\n\n\nSummary: Heparanase (Hpa) is the only endoglycosidase enzyme in mammalian cells capable of cleaving heparan sulfate. In addition to the well-known functions in the regulation of glycosaminoglycans integrity\, accumulating evidence indicate Hpa plays vital roles in virus infection\, while the mechanisms are not yet fully understood\, especially in RNA virus infection. In this study\, we found Zika virus (ZIKV) reduced the expression of Hpa at the late life cycle of viral infection. Overexpression of wild-type Hpa but not the inactive enzymatic mutant (Hpa-DM) in Huh7 cells dramatically decreased the production of infectious virions. These findings were further confirmed by the results from Mouse Embryonic Fibroblasts (MEF) cells that knock-out of Hpa enhanced ZIKV production\, while overexpression of Hpa suppressed the production of virions. Further investigations indicated that overexpression of Hpa in Huh7 cells exhibited no obvious effects on ZIKV’s attachment/entry and replication steps\, but resulted in a significant downregulation of ZIKV envelope protein (E). Hpa was also shown to specifically degrade E protein when performed co-transfection of plasmids encoding Hpa and viral proteins in HEK-293T cells. Altogether\, our study discovered an unrecognized role of Hpa in virus infection and demonstrated that Hpa serves as a restriction factor for ZIKV infection.
URL:https://www.scilifelab.se/event/campus-uppsala-phd-postdoc-seminars/
LOCATION:Online event via Zoom
CATEGORIES:Community
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220315T110000
DTEND;TZID=Europe/Stockholm:20220315T115000
DTSTAMP:20260403T191212
CREATED:20220309T144728Z
LAST-MODIFIED:20220309T152030Z
UID:10000549-1647342000-1647345000@www.scilifelab.se
SUMMARY:Uppsala PhD & PostDoc seminars
DESCRIPTION:Welcome to SciLifeLab Uppsala PhD&Postdoc seminars!We are very happy to host exciting talks by PhD students and Postdocs from a great variety of fields within SciLifeLab. \n\n\n\nSpeakers: \n\n\n\nPierre Cheung\, PhD student\, department of Medicinal ChemistryTranslational PET ImagingVijay Josyula\, PhD student\, department of Medical Cell Biology
URL:https://www.scilifelab.se/event/uppsala-phd-postdoc-seminars/
LOCATION:Air&Fire\, SciLifeLab Stockholm\, Tomtebodavägen 23A\, Solna\, Sweden
CATEGORIES:Community
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