This unit aims at a thorough understanding of the in vitro pharmacology of a candidate drug therapy (single drug or a drug mixture)
The in vitro and systems pharmacology unit provides the projects at the DDD platform with a thorough understanding of the in vitro efficacy and toxicity of a drug therapy (single drug or a drug combination) using relevant cellular model systems. Situated at the Clinical Pharmacology laboratory at Uppsala University Hospital the unit also offers the possibility to support drug discovery projects by testing putative novel therapies on primary human cells. In vitro toxicity of antibacterial compounds is also tested at the Clinical Pharmacology as part of the IMI ENABLE consortium.
Time- and dose-dependence of in vitro efficacy/toxicity on cells are studied using live cell imaging, in addition to biochemical end-point assays.
We also aim at elucidating mechanism of action of novel drugs, and identify biomarker signatures, by analysing transcriptomics data.
Finally the unit also offers advice on how to incorporate the data in proof of concept studies.