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PhD in Molecular profiling in tumour tissue at single cell resolution for biomarker discovery

Published: 2018-03-29

In the framework of the European collaborative project AiPBAND (An Integrated Platform for Developing Brain Cancer Diagnostic Techniques) under Marie Skłodowska-Curie Actions, Stockholm University (Sweden) is recruiting one Early Stage Researcher (ESR). This ESR will be enrolled in the AiPBAND Innovative Training Network programme in which a group of early stage researchers will be exposed to the full breadth of disciplines associated with a new generation of biosensing techniques and diagnostic systems that can provide diagnosis, prognosis and monitoring of brain cancer, from both the academic and non-academic sectors. Through a set of synergistic research projects in gliomas diagnosis, targeting the most important and urgent clinical needs, the ESRs are offered a holistic training program, preparing them to be lead players in the field.

The specific research project offered by Stockholm University comprises the development of assays and methods for tissue profiling in clinical brain specimens. The work will be based on spatially resolved gene expression analysis of brain tissue for biomarker discovery and validation of biomarkers in blood. The project involves development of assays based on established in situ next generation sequencing (NGS) technology, allowing highly multiplexed biomarker analysis at single cell resolution in sections of formalin fixed paraffin embedded (FFPE) tissues from gliomas and generating biomarkers based on both cellular and molecular profiling. The technology is specific and sensitive enough to record even point mutations, and works well for mRNA profiling in tissues. The project will aim for the development of in situ NGS technology for miRNA profiling and protein profiling in FFPE tissue sections. The project will also involve intensive high resolution fluorescence microscopy and image analysis modules. The biomarkers will guide the development of assays for blood-based sensors. The ESR will work closely with clinical oncologists/pathologists in London and Rome.

More information on the position and application:


Organisation: Stockholm University, Stockholm

Researcher profile: First Stage Researcher (R1)

Application deadline: 27/04/2018 18:00 – Europe/Brussels

Type of contract: Temporary

Job status: Full-time

Offer starting date: June 1st, 2018

EU Research Framework Programme: H2020 / Marie Skłodowska-Curie Actions

Marie Curie Grant Agreement Number: 764281