Postdoctoral studies in translational leukemia/cancer biology (Scholarship)

Published: 2019-11-18


Karolinska Institutet, Department of Oncology-Pathology
Forskargrupp Lehtiö

Division
The postdoctoral studies will be conducted in the Cancer proteomics Mass spectrometry (MS) research group at Science for Life Laboratory (SciLifeLab). Janne Lehtiö is heading the group and the proteomics facility at KI and SciLifeLab. We are a translational group of scientists with a drive to improve personalized cancer treatment by the means of mass spectrometry-based proteome analysis. Proteomics is a research field aiming to study proteins on a systems level by simultaneous analysis of thousands of proteins. We aim to gain new knowledge on proteins in the context of biological networks, to discover biomarkers and understand how genome changes impact the proteome level. In addition to the MS-data, we also generate genomic and transcriptomic data at SciLifeLab, which are used together with proteomics data to gain in-depth insights into cancer biology. We are engaged in method development projects to improve tissue, cell line and plasma proteomics, for example, using high resolution peptide isoelectric focusing (HiRIEF), subcellular localization analysis and targeted proteomics to increase sensitivity and throughput in clinical validation of proteomics data. We are also applying thermal proteome profiling (TPP) to study target engagement of drugs in variety of contexts.

To strengthen our leukemia sub-group led by assistant professor Rozbeh Jafari we seek a postdoctoral researcher within the field of molecular and cellular biology in leukemia research.

 

Duties
The postdoc will work on validating novel biomarkers from our previous analysis of genomics and proteomics data derived from childhood acute lymphoblastic leukemia (ALL) cell lines as well as clinical specimens using standard molecular and cellular biology methods. The postdoc will also learn and apply thermal proteomics methods such as CETSA and TPP to study and characterize investigational oncology drugs in relevant disease models. An ideal candidate has a strong scientific background with a desire to work with cancer research in a translational, interdisciplinary and international research environment. We are seeking a scientist that is creative, independent and goal-oriented, and committed to solve scientific research questions. The applicant is expected to work in a diligent manner to take responsibility in generating properly controlled scientific data of high quality as well as generating new hypothesis.

The current position offers great possibility for innovative research combining genomics, quantitative- and thermal proteomics together with a dedicated group of scientists.

 

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

 

Other requirements
We are looking for an outstanding and highly motivated candidate with a PhD in cell- or molecular biology, immunology, biotechnology, drug development or equivalent field. We expect the candidate to have a strong scientific background with relevant and extensive expertise in molecular and cellular biology techniques to study cancer biology. Experience with the following techniques are required: maintenance of primary cell cultures and cell lines, cell viability assays, standard cell- and molecular biology techniques including DNA/RNA/protein preparation and characterization, immunoprecipitation, western blot, RT-PCR, siRNA/shRNA transfection and gene overexpression.

Previous experience and expertise in hematological cancers such as ALL is ideal. Experience with drug development and screening, mass spectrometry based proteomics or other omics technologies are highly valued and beneficial. The candidates should also be able to take a strong lead in managing and driving the project(s). Since the postdoctoral studies involves close interaction with several researchers, an emphasis is also placed on interpersonal and analytical skills as well as communication skills in English (spoken and written).

 

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable. During this period, the postdoc will be encouraged to apply for external funding.

 

Contact
Rozbeh Jafari, rozbeh.jafari@ki.se

 

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