Postdoctoral researcher in Integrated Structural Biology of Chromatin Complexes


The Deindl lab (www.deindl-lab.com) is an international and ambitious research team that provides a stimulating and friendly environment for hard-working scientists with a genuine interest in tackling important biological questions. We have recently been awarded an ERC starting grant to investigate the molecular mechanisms of protein machines using a highly multidisciplinary approach that combines state-of-the-art single-molecule fluorescence imaging (see for example, Deindl et al., Cell 2013 or Hwang*, Deindl*, et al., Nature 2014) with a range of biophysical, structural, and biochemical techniques. We are located at the SciLifeLab and the Department of Cell and Molecular Biology (ICM) at Uppsala University, one of the most international, interdisciplinary and successful research departments in molecular biosciences in Europe.

Job description
The starting date for the position is as soon as possible or per agreement. The position is initially for one year but offers a longer-term perspective.

We are seeking a highly motivated postdoctoral researcher to investigate the mechanisms and regulation of chromatin-associated complexes using an integrated structural biology approach that combines cryo-EM, crystallography, and crosslinking-mass spectrometry. The researcher will benefit from access to state-of-the-art facilities, infrastructure, resources and support for all these technologies, as well as collaborators who are international leaders in their fields. In particular, we have access to the SciLifeLab cryo-EM facility with state-of-the-art cryo-EM equipment, including Titan Krios and Talos Arctica armed with the latest generation direct electron detectors and a modern computational infrastructure.

Qualifications

Applicants should possess a PhD in the life sciences, biophysics or physics, bioengineering, physical chemistry, or a related discipline that the group leader considers suitable. A background in cryo-electron microscopy or X-ray crystallography, documented by at least one peer-reviewed first-author publication is strictly required. Good English language skills are essential. The ability to work in a team, good organizational skills as well as initiative, flexibility and good learning ability are required. Particular emphasis will be placed on personal suitability.

To apply
The application should be emailed to Assistant Professor Sebastian Deindl (sebastian.deindl@icm.uu.se) and be written in English, include a short letter of motivation detailing the applicant’s research interests and expertise, a CV with a list of publications, a copy of the PhD degree and the contact information for at least two referees who can provide references.