Structural biology plays a critical role in understanding the molecular basis of life. It lets us visualize and analyse the three-dimensional structure of biological molecules, and allows us to understand how processes such as metabolism, gene expression, programmed cell death work at a fundamental level, and how to safely target them pharmaceutically. In many cases, it is the most informative clue biological research can hope for in order to understand and discover the principles of life.
In the lab we develop methods to understand structural biology data better, in particular cryo-EM reconstructions and the datasets that are used to generate them. We strive to make useful tools that change how researchers consider their data, enabling them to go further and not just discover but also explain and justify new perspectives on fundamental biology.
