Japanese Business federation KEIDANREN visits SciLifeLab
The Japanese Business federation KEIDANREN, along with the newly appointed Japanese ambassador to Sweden, H.E. Shigeyuki Hiroki, visited SciLifeLab on Wednesday Nov 7 as part of KEIDANREN’s Mission to Sweden 2018. The mission is part of the ongoing 150th anniversary of diplomatic relations between Japan and Sweden. In addition to SciLifeLab, the delegation visited Ericsson, the Confederation […]
Online gamers and artificial intelligence to improve image classification
As reported back in 2016, Emma Lundberg’s research group has, by collaborating with the gaming company Massive Multiplayer Online Science, had their project about classification of protein images included in the online game EVE. EVE is played by over half a million people every month, meaning quite a few contributions to the group’s work – over 300 000 gamers played the game and generated 33 million protein image classifications.
Sixteen new Technology Development Projects (TDPs) announced
To contribute in keeping SciLifeLab infrastructure at cutting-edge, a call for Technology Development Projects (TDPs)was opened during spring 2018. Now the sixteen projects, which will receive a total of 40 MSEK over a two-year period, are revealed. The purpose of the TDP initiative is to enable the development, exploration and optimization of new technologies in […]
Mapping the genome of the Aspen tree
After almost ten years of work, an international team, lead by researchers at Umeå University and SLU, has sequenced the entire genome of the two species of Aspen trees. Mapping a species’ gene set is often considered the key piece of the puzzle in biology as, when it’s done, all sorts of studies can be performed. The mapping of the human genome made way for a broad range of breakthroughs in the 21st century’s medicine and hopefully, mapping the Aspen tree’s genome will lay a foundation for many future studies in the area.
Single-cell RNA sequencing reveals platinum chemotherapy resistance gene
An RNA sequencing study led by Per Uhlén from Karolinska Institutet identifies the gene COX7B to be associated with cancer cell resistance to platinum-based chemotherapy, such as cisplatin. The results also demonstrate that the membrane-associated protein CD63 may be used as a surrogate marker for platinum resistance. Knock-down of COX7B in cancer cells decreased the sensitivity […]
Selfish genes causing fungal fratricide
Selfish genes, genes that are passed on through generations without any benefit to the individual, are thought to be an important driver of evolution. With support from the National Genomics Infrastructure at SciLifelab, researchers at Uppsala University have sequenced two selfish genes found in the fungus Neurospora intermedia, both of which cause fungal spores to kill their siblings.
Enhanced validation of antibodies for research applications
There is a need for standardized validation methods for antibody specificity and selectivity. In this paper, the researchers show that the five pillars involving orthogonal methods, genetic knockdown, recombinant expression, independent antibodies and capture mass spectrometry analysis, can be used to validate antibodies for Western blot applications in a standardized and systematic manner. The study […]
Adiponectin proposed biomarker for detection of Metabolic Syndrome
The hormone adiponectin is put forward as a useful diagnostic indicator of Metabolic Syndrome following a meta-analysis of existing scientific data from more than 7 000 individuals. The study, led by Adil Mardinoglu (KTH/SciLifeLab), shows that lower levels of circulating adiponectin in blood are highly associated with increased occurrence of Metabolic Syndrome – defined as […]