Wolfgang is an expert in protein production, enzymology and integrated structural biology approaches. As such he provides and develops life science infrastructure for protein production, protein characterization, biophysics and protein structure determination (www.lp3.lu.se & www.pps.gu.se/en). His research beýond the infrastructures features biochemical – structural biology approaches to study enzymes.
Wolfgang Knecht
Key Publications
A truncated CDC14A retains catalytic structure and phosphatase activity preserving male fertility but causes nonsyndromic deafness
Journal of Biological Chemistry, 2025
Off-target binding of the histone deacetylase inhibitor vorinostat to carbonic anhydrase II and IX
Acta Crystallographica Section F Structural Biology Communications, 2025
Structural basis for small molecule binding to the SARS-CoV-2 nsp10-nsp14 ExoN complex
2025
A mild skeletal phenotype with overlapping features of Miller syndrome and functional characterisation of two new variants of human dihydroorotate dehydrogenase
Heliyon, 2024
Protein production, kinetic and biophysical characterization of three human dihydroorotate dehydrogenase mutants associated with Miller syndrome
Nucleosides, Nucleotides & Nucleic Acids, 2022