My research is centred around developing and applying affinity proteomics methods allowing for both high-throughput and multiplex protein analysis in human body fluids. We design project-specific protein panels and can make use of the method’s full capacity in terms of multiplexing through a close collaboration with the Human Protein Atlas project providing antibodies to the majority of the human proteome. Collaborations with national and international clinicians and researchers with aligned research interests allow analysis of large and well-characterised sample cohorts.
The overall aim of my research is to find proteins and protein profiles that can help us understand disease pathology with potential for clinical applications and patient stratification. The main focus is currently on amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD) and psychiatric disorders but we also have ongoing studies and collaborations in the context of other neurological diseases. Data analysis is focused on finding associations of protein levels within and across these diseases making use of available information such as diagnosis and clinical phenotypes. We also apply a more data-driven approach where we move beyond the current clinically defined phenotypes in the search for novel patient subgroups.