Focusing on dynamic structural biology, my group has leading expertise in deciphering protein structural changes (Nature 2014; Nat. Chemistry 2024; Elife 2020). We employ innovative time-resolved X-ray solution scattering (Nat. Meth 2010; Nat Meth 2024), crystallography (Nature 2021), and multidimensional optical spectroscopies (JACS 2016, JACS 2018); often with a strong computational component (JCTC 2014). We develop software and hardware for the cryo EM user community at SciLifeLab.
Sebastian Westenhoff
Uppsala University
Key Publications
Chemical Mechanism of Allosteric and Asymmetric Dark Reversion in a Bacterial Phytochrome Uncovered by Cryo-EM
Journal of the American Chemical Society, 2025
Chemical mechanism of allosteric and asymmetric dark reversion in a bacterial phytochrome uncovered by cryo-EM.
2025
Refolding of the Deinococcus Radiodurans phytochrome photosensory module and an extended backbone resonance assignment by solution NMR
Protein Expression and Purification, 2025
Cryo-EM structures of a bathy phytochrome histidine kinase reveal a unique light-dependent activation mechanism
Structure, 2024