Göran Jönsson

Lund university

Key Publications

1. Cabrita R, Lauss M, Sanna A, Donia M, Skaarup Larsen M, Mitra S, Johansson I,
Phung B, Harbst K, Lövgren K, Jirström K, Olsson H, Ingvar C, Isaksson K, Schadendorf
D, Schmidt H, Bastholt L, Carneiro A, Wargo JA, Svane IM, Jönsson G. Tertiary
lymphoid structures improve immunotherapy and survival in melanoma. Nature. 2020
Jan;577(7791):561-565

2. Lauss M, Phung B, Borch TH, Harbst K, Kaminska K, Ebbesson A, Hedenfalk I, Yuan
J, Nielsen K, Ingvar C, Carneiro A, Isaksson K, Pietras K, Svane IM, Donia M, Jönsson
G. Molecular patterns of resistance to immune checkpoint blockade in melanoma. Nat
Commun. 2024 2024 Apr 9;15(1):3075

3. Lauss M, Donia M, Svane IM, Jönsson G. B Cells and Tertiary Lymphoid Structures:
Friends or Foes in Cancer Immunotherapy? B Cells in Cancer. Clin Cancer Res. 2022
May 2;28(9):1751-1758

4. Elewaut A, Estivill G, Bayerl F, Castillon L, Novatchkova M, Pottendorfer E, Hoffmann-
Haas L, Schönlein M, Nguyen TV, Lauss M, Andreatta F, Vulin M, Krecioch I, Bayerl J,
Pedde AM, Fabre N, Holstein F, Cronin SM, Rieser S, Laniti DD, Barras D, Coukos G,
Quek C, Bai X, Muñoz I Ordoño M, Wiesner T, Zuber J, Jönsson G, Böttcher JP,
Vanharanta S, Obenauf AC. Cancer cells impair monocyte-mediated T cell stimulation to
evade immunity. Nature. 2025 Jan;637(8046):716-725.

5. Lauss M, Donia M, Harbst K, Andersen R, Mitra S, Rosengren F, Salim M, Vallon-
Christersson J, Törngren T, Kvist A, Ringnér M, Svane IM, Jönsson G. Mutational and
putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma.
Nat Commun. 2017 Nov 23;8(1):1738.

Over the past decade, immunotherapy has become a cornerstone in enhancing survival outcomes for cancer patients. Recent studies, including our own, have provided compelling evidence that tertiary lymphoid structures (TLS) are pivotal in orchestrating anti-tumor immune responses in melanoma. These specialized immune niches are critical determinants of immunotherapy efficacy, influencing patient outcomes. We are actively trying to understand the functional role and clinical significance of TLS in cancer. 

Group Members

Martin Lauss
Katja Harbst
Bengt Phung
Kamila Kaminska
Florian Jeanneret
Jacob Karlström
Cecilia Wahlström
Zacharias Ringstedt

Last updated: 2025-12-02

Content Responsible: Hampus Pehrsson Ternström(hampus.persson@scilifelab.uu.se)