the Department of Molecular Biosciences, The Wenner-Gren Institute (MBW) experimentally addresses fundamental problems in molecular cell biology, integrative biology, and infection and immunobiology. State-of-the art and advanced methodologies are applied in a professional research environment characterized by its well-established international profile. The institute has 30 research groups with a research staff of 180, of which 65 are PhD students. More information about us, please visit: the Department of Molecular Biosciences, the Wenner-Gren Institute.
Project description
Metabolic control of cell nuclei
We are actively seeking a highly motivated PhD student with a passion for developing experimental methods to join our team. In this role, you will be involved in a groundbreaking project aimed at studying protein interactions in cells and tissues, making use of the expertise of the Piazza lab. With proof-of-concept already established, you will work to refine and optimize the method to achieve broad applicability and high reproducibility. You will have the opportunity to apply this novel approach to explore pressing biomedical questions and leveraging this knowledge to advance treatments for human tumors and immunotherapies.
The Piazza laboratory (Piazza Lab) uses mass spectrometry-based approaches to study protein interactions in cell and tissues with proteomics. In this project you will learn experimental and computational approaches to tackle fundamental biological questions with medical relevance using innovative system-wide techniques. You will work on an exciting multidisciplinary project integrating multiomics approaches that aims to understand how metabolism and metabolic enzymes control chromatin in bulk and at single cell level. You will have access to state-of-the-art instrumentation at the SciLifeLab laboratories in Solna and be involved in international cross-disciplinary collaborations.
Qualification requirements
In order to be admitted to postgraduate education, the applicant must have the general and specific entry requirements. The qualification requirements must be met by the deadline for applications.
You meet general entry requirements if you have completed a second-cycle degree, or completed courses equivalent to at least 240 higher education credits, of which 60 credits must be in the second cycle, or have otherwise acquired equivalent knowledge in Sweden or elsewhere.
Specific entry requirements are described in the general syllabus for doctoral studies in the field of molecular biology, stipulates that the applicant at the undergraduate level has at least 120 credits in molecular biology, biology, chemistry or the equivalent. And at least 60 credits at an advanced level in molecular biosciences or the equivalent, of which at least 30 credits must consist of an independent thesis project.
Selection
The selection among the eligible candidates will be based on their capacity to benefit from the training. The following criteria will be used to assess this capacity:
- Documented knowledge in a relevant field of research
- A strong interest in interdisciplinary research and integration of genomics and proteomics concepts are the requisite skills for this position
- A strong interest in quantitative biology
- Curiosity and motivation in learning multiple -omics approaches
- Preferred experience includes familiarity with quantitative proteomics or NGS library generation
- Previous experience with work with human cancer cell lines, stem cells, and/or immunohistochemistry is a plus
- Programming skills with Python or R is a plus
- Excellent communication skills
- A solid experimental or computational background and excellent communication skills in English
- Capacity for analytical and creative thinking
- Initiative
- Independence
- Ability to collaborate.
Admission Regulations for Doctoral Studies at Stockholm University.
About the employment
We offer a fixed-term employment as a doctoral student according to Chapter 5 of the Higher Education Ordinance (1993:100). The period of employment may not be longer than what corresponds to full-time doctoral education for four years. As a doctoral student, you should primarily devote yourself to your own doctoral education, but the employment may include work with education, research and administration to a limited extent (maximum 20 %).
A new employment as a doctoral student is for a maximum of one year, the employment is then renewed for a maximum of two years at a time.
Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.
Contact
For more information, please contact Ilaria Piazza, ilaria.piazza@su.se.
Application
Apply for the PhD student position at Stockholm University’s recruitment system. Attach a personal letter and CV as well as the attachments requested in the application form. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.
The instructions for applicants are available at: How to apply for a position.
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