From Folding to Function: How Trafficking Receptors Shape Membrane Protein Biogenesis
August 14, 2026 @ 14:00 – 15:00 CEST
From Folding to Function: How Trafficking Receptors Shape Membrane Protein Biogenesis.
Speaker: Prof. Simion Newstead from Oxford University
Membrane proteins perform essential cellular functions, but before they reach their final destination, they must fold correctly and pass stringent quality control in the endoplasmic reticulum (ER). How cells coordinate membrane protein folding with selective export from the ER remains poorly understood. In this seminar, I will discuss recent structural and mechanistic insights into the role of trafficking receptors in membrane protein biogenesis. Using cryo-electron microscopy alongside biochemical and cell-biological approaches, we show how cornichon trafficking receptors recognise membrane-protein cargoes, remodel the surrounding membrane, and recruit the COPII machinery to drive ER export. These studies reveal trafficking receptors as active regulators of membrane protein maturation and provide a structural framework for understanding how membrane proteins are assembled and trafficked within the cell.
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