Mats Larhed

Professor in Medicinal Chemistry, Uppsala University

Key Publications

J. Lindman, A. Yadav, J. Gising, M. Larhed*: Two-chamber aminocarbonylation of aryl
bromides and triflates using amino acids as nucleophiles.
J. Org. Chem. 88 (2023), 12978-12985. DOI: 10.1021/acs.joc.3c00972

J. Wannberg, J. Gising, M. Henriksson, D. D. Vo, J. Sävmarker, J. Sallander, H. Gutiérrez-de Terán, J. Larsson, S. Hamid, H. Ablahad, I. Spizzo, T. A. Gaspari, R. E. Widdop, A. Grönbladh, N. N. Petersen, M. Backlund, M. Hallberg, M. Larhed*: N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands.
Eur. J. Med. Chem. 265 (2024) 116122 (11 p). DOI: 10.1016/j.ejmech.2024.116122

K. Engen, T. Lundbäck, A. Yadav, S. Puthiyaparambath, U. Rosenström, J. Gising, A. Jenmalm-Jensen, M. Hallberg, M. Larhed*: Inhibition of Insulin-regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation.
Int. J. Mol. Sci. 25 (2024) 2516 (30 p). DOI: org/10.3390/ijms25052516

J. Beveridge, M. Söderström, R. Prieto-Díaz, H. Gutierrez-de-Teran, L. R. Odell, M. Hallberg, M. Larhed*, J. Gising*: Benzylhydroxamic Acids as Inhibitors of Insulin Regulated Aminopeptidase (IRAP).
Eur. J. Med. Chem. Rep. 12 (2024) 100215 (11 p). DOI: org/10.1016/j.ejmcr.2024.100215

J. Beveridge, M. Söderström, R. Prieto-Díaz, H. Gutierrez-de-Teran, L. R. Odell, M. Hallberg, M. Larhed*, J. Gising*: Benzylhydroxamic acids as IRAP Inhibitors: Sulfonamide Variations.
SynLett, 36 (2025) 2666-2670. DOI: org/10.1055/a-2562-7204

J. Lindman, S. Puthiyaparambath, J. Gising, L. R. Odell, M. Larhed*: A diastereoselective Mizoroki-Heck reaction for synthesis of spirooxindole-based unnatural amino acids using a Boc-protected amine as chiral auxiliary.
SynLett, 36 (2025) 2009-2013. DOI: 10.1055/a-2564-4920

J. Gising, J. Wannberg, R. Isaksson, J. Sallander, H. Gutiérrez-de-Terán, M. Backlund, M. Hallberg and M. Larhed*. New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold.
Bioorg. Med. Chem. 140 (2026) 118710 (6 p). DOI: 10.1016/j.bmc.2026.118710

Research interests

Larheds main research interests are: I) the discovery and development of new pharmaceutical agents for treatment of pulmonary fibrosis (IPF) and other inflammatory diseases, II) development of new chemical methodologies of importance for drug discovery.

He has published more than 240 scientific articles and ten approved patents (all sold).

He held the position of Vice-Rector for Medicine and Pharmacy 2020–2026 and holds at present the position as Adviser to the Vice-Chancellor at Uppsala University. Larhed is member of The Royal Society of Sciences in Uppsala, The Society of Arts and Sciences of Uppsala and The Royal Swedish Academy of Engineering Sciences (IVA). Larhed is engaged in the development of the Beijer laboratory for drug discovery.

Group members

Marcus Söderström
Sabina Yashmin

Contact

mats.larhed@ilk.uu.se

Last updated: 2026-07-13

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