Research focus
We work on membrane protein biogenesis and cotranslational protein folding.
Group Members:
Ane Metola
Justin Westerfield
Morgana Kellogg
Gunnar von Heijne
Platform Scientific Director: Cellular and Molecular Imaging, Stockholm University
Keywords
Key Publications
Westerfield1, J.M., Kozojedová, P., Juli, C., Metola, A., and von Heijne, G. (2025) Cotranslational membrane insertion of the voltage-sensitive K+ channel KvAP. Proc Natl Acad Sci USA 122, e2412492122.
Mermans, D., Nicolaus, F., Fleisch, K., and von Heijne, G. (2022) Cotranslational folding and assembly of the dimeric E. coli inner membrane protein EmrE. Proc Natl Acad Sci USA 119, e2205810119.
Teufel, F., Almagro Armenteros, J.J., Rosenberg Johansen, A., Halldór Gislason, M., Irby Pihl, S., Tsirigos, K.D., Winther, O., Brunak, S., von Heijne, G., Nielsen, H. (2022) SignalP 6.0 achieves signal peptide prediction across all types using protein language models. Nature Biotech, https://doi.org/10.1038/s41587-021-01156-3.
Nilsson, O.B., Hedman, R., Marino, J., Wickles, S., Bischoff, L., Johansson, M., Müller-Lucks, A., Trovato, F., Puglisi, J.D., O’Brien, E., Beckmann, R., and von Heijne, G. (2015) Cotranslational protein folding inside the ribosome exit tunnel. Cell Reports 12, 1533-1540.
White, S.H., von Heijne, G., and Engelman, D.A. (2022; Japanese edition 2025) Cell boundaries: How membranes and their proteins work (1st edition). Garland Science (New York). 564 pages.